213 |
La Distia Nora R., Putera I., Khalisha D.F., Septiana I., Sitompul R. |
56001881000;56485949000;57219417896;57219417256;8312163900; |
The diagnostic value of polymerase chain reaction for ocular tuberculosis diagnosis in relation to antitubercular therapy response: a meta-analysis |
2021 |
International Journal of Infectious Diseases |
110 |
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394 |
402 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113172042&doi=10.1016%2fj.ijid.2021.07.075&partnerID=40&md5=2517c80887d20c78446a294388261c14 |
Department of Ophthalmology, Faculty of Medicine, University of Indonesia – Cipto Mangunkusumo Kirana Eye HospitalJakarta, Indonesia; Department of Immunology, Erasmus Medical Center, Rotterdam, Netherlands; University of Indonesia Hospital (RSUI), Depok, West Java, Indonesia |
La Distia Nora, R., Department of Ophthalmology, Faculty of Medicine, University of Indonesia – Cipto Mangunkusumo Kirana Eye HospitalJakarta, Indonesia, Department of Immunology, Erasmus Medical Center, Rotterdam, Netherlands, University of Indonesia Hospital (RSUI), Depok, West Java, Indonesia; Putera, I., Department of Ophthalmology, Faculty of Medicine, University of Indonesia – Cipto Mangunkusumo Kirana Eye HospitalJakarta, Indonesia; Khalisha, D.F., Department of Ophthalmology, Faculty of Medicine, University of Indonesia – Cipto Mangunkusumo Kirana Eye HospitalJakarta, Indonesia; Septiana, I., Department of Ophthalmology, Faculty of Medicine, University of Indonesia – Cipto Mangunkusumo Kirana Eye HospitalJakarta, Indonesia; Sitompul, R., Department of Ophthalmology, Faculty of Medicine, University of Indonesia – Cipto Mangunkusumo Kirana Eye HospitalJakarta, Indonesia |
Background: Polymerase chain reaction (PCR) is currently considered the method of choice for diagnosing ocular tuberculosis. However, the sensitivity and specificity of PCR using ocular samples remain uncertain. Our meta-analysis aimed to review the diagnostic accuracy of PCR testing in confirming ocular tuberculosis, with responses to antitubercular therapy (ATT) as reference indices. Methods: A systematic literature search of the PubMed, EBSCOHost, Scopus, and Google Scholar databases was performed using the standardized PRISMA guideline. Observational studies reporting both PCR MTb positivity and ATT response were included. Meta-analysis was performed to estimate the pooled positivity rate, sensitivity, specificity, positive and negative likelihood ratios, diagnostic odds ratios (DOR), and summary receiver operating curves (SROC). Results: The pooled positivity rate for PCR MTb was 0.55 (95% CI 0.44–0.67). The overall sensitivity and specificity were 88% (95% CI 83–92) and 71% (95% CI 60–80), respectively. The pooled DOR was 12.15 (95% CI 5.55–26.62). The area under the SROC was 0.83. Conclusions: The diagnostic accuracy of PCR Mtb is not sufficient for use as a benchmark for ocular TB diagnosis routinely based on ATT response. A negative result may help avoid prescribing unnecessary ATT in dilemmatic cases. © 2021 The Author(s) |
Diagnostic accuracy; Mycobacterium tuberculosis; polymerase chain reaction; uveitis |
ethambutol; ethambutol plus isoniazid plus pyrazinamide plus rifampicin; isoniazid; isoniazid plus rifampicin; pyrazinamide; rifampicin; steroid; tuberculostatic agent; tuberculostatic agent; antibiotic therapy; Article; controlled study; diagnostic accuracy; diagnostic test accuracy study; diagnostic value; false negative result; false positive result; human; inflammation; meta analysis; nonhuman; ocular tuberculosis; polymerase chain reaction; quantitative analysis; receiver operating characteristic; recurrent disease; regression analysis; sensitivity and specificity; serpiginous choroiditis; steroid therapy; systematic review; treatment duration; treatment response; genetics; Mycobacterium tuberculosis; polymerase chain reaction; tuberculosis; Antitubercular Agents; Humans; Mycobacteriu |
Elsevier B.V. |
12019712 |
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34364996 |
Article |
Q1 |
1278 |
2980 |
|
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373 |
Dewi R., Kaswandani N., Karyanti M.R., Setyanto D.B., Pudjiadi A.H., Hendarto A., Djer M.M., Prayitno A., Yuniar I., Indawati W., Prawira Y., Handryastuti S., Sjakti H.A., Hidayati E.L., Muktiarti D., Soebadi A., Puspaningtyas N.W., Muhaimin R., Rahmadhany A., Octavius G.S., Puspitasari H.A., Jasin M.R., Tartila T., Putri N.D. |
57190859324;57195941745;56290680800;57203009929;18435202300;57204142249;12771087900;57193342301;57222295046;57190171077;55455747000;18434003700;57195720458;57200542624;57189047743;56986580800;57223288515;57223307995;57223290366;57221016506;57214119502;57223292665;57223304533;57200573842; |
Mortality in children with positive SARS-CoV-2 polymerase chain reaction test: Lessons learned from a tertiary referral hospital in Indonesia |
2021 |
International Journal of Infectious Diseases |
107 |
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78 |
85 |
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9 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105478543&doi=10.1016%2fj.ijid.2021.04.019&partnerID=40&md5=6ef75a9ece8a84ed984ec94cf9c3f923 |
Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Dewi, R., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kaswandani, N., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Karyanti, M.R., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setyanto, D.B., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Pudjiadi, A.H., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hendarto, A., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Djer, M.M., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Prayitno, A., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yuniar, I., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Indawati, W., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Prawira, Y., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Handryastuti, S., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sjakti, H.A., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hidayati, E.L., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Muktiarti, D., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Soebadi, A., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Puspaningtyas, N.W., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Muhaimin, R., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahmadhany, A., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Octavius, G.S., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Puspitasari, H.A., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Jasin, M.R., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tartila, T., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Putri, N.D., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: The incidence of coronavirus disease 2019 (COVID-19) is still increasing rapidly, but little is known about the prevalence and characteristics of fatal cases in children in Indonesia. This study aimed to describe the characteristics of children with COVID-19 with fatal outcomes in a tertiary referral hospital in Indonesia. Methods: This cross-sectional study used data collected from the medical records of patients with COVID-19 admitted to Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia from March to October 2020. Results: During the study period, 490 patients were admitted and diagnosed with suspected and probable COVID-19. Of these patients, 50 (10.2%) were confirmed to have COVID-19, and 20 (40%) had a fatal outcome. The fatality rate was higher in patients aged ≥10 years, categorized with severe disease upon admission, PaO2/FiO2 ratio ≤300 mmHg and chronic underlying diseases. The most common clinical manifestations were generalized symptoms, while acute respiratory distress syndrome (8/20) and septic shock (7/20) were the two most common causes of death. Increased procalcitonin, D-dimer, lactate dehydrogenase and presepsin levels were found in all fatal cases. One patient met the criteria of multisystem inflammatory syndrome in children. Conclusion: Our work highlights the high mortality rate in paediatric patients with positive SARS-CoV-2 polymerase chain reaction test. These findings might be related to or co-incided with COVID-19 infection. Further studies are needed to improve understanding of the role of severe acute respiratory syndrome coronavirus-2 in elaborating the mechanisms leading to death in children with comorbidities. © 2021 The Author(s) |
Children; COVID-19; Indonesia; Outcome; SARS-CoV-2 |
antibiotic agent; biological marker; D dimer; dobutamine; dopamine; enoxaparin; epinephrine; hydrocortisone; immunoglobulin; lactate dehydrogenase; lopinavir; noradrenalin; presepsin; procalcitonin; ritonavir; steroid; unclassified drug; adolescent; adult; adult respiratory distress syndrome; age; Article; artificial ventilation; cause of death; child; childhood mortality; clinical feature; coronavirus disease 2019; cross-sectional study; disease severity; fatality; female; Horowitz index; hospital admission; human; Indonesia; infant; major clinical study; male; mortality rate; newborn; pediatric multisystem inflammatory syndrome; polymerase chain reaction; preschool child; real time polymerase chain reaction; school child; septic shock; tertiary care center; complication; mortality; Adole |
Elsevier B.V. |
12019712 |
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33857609 |
Article |
Q1 |
1278 |
2980 |
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