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Abdullah M., Sudrajat D.G., Muzellina V.N., Kurniawan J., Rizka A., Utari A.P., Pribadi R.R., Idrus M.F., Yusra Y., Meilany S., Surandy A., Shatri H., Rinaldi I., Pitoyo C.W., Renaldi K. |
7103393434;54893136100;57223968527;57193251655;57203243658;57113585900;57194732282;57223976376;57220998367;57193709281;57223964417;28767986500;23475122400;26022606900;57190963547; |
The value of anal swab RT-PCR for COVID-19 diagnosis in adult Indonesian patients |
2021 |
BMJ Open Gastroenterology |
8 |
1 |
e000590 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106611204&doi=10.1136%2fbmjgast-2020-000590&partnerID=40&md5=cc17ce689ac73f1e46021151c9319871 |
Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Indonesia Medical Education and Research Institute - Human Cancer Research Center, University of Indonesia Faculty of Medicine, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Hepatobilliary Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Geriatric Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Department of Clinical Pathology, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region Jakarta, Indonesia; Research Center for Virology and Cancer Pathobiology, University of Indonesia Faculty of Medicine, Jakarta, Special Capital Region of Jakarta, Indonesia; Psychosomatic and Palliative Care Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Special Capital Region of Jakarta, Central Jakarta, Indonesia; Hematology and Medical Oncology Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Respirology and Critical Care Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia |
Abdullah, M., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia, Indonesia Medical Education and Research Institute - Human Cancer Research Center, University of Indonesia Faculty of Medicine, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Sudrajat, D.G., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Muzellina, V.N., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Kurniawan, J., Hepatobilliary Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Rizka, A., Geriatric Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Utari, A.P., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Pribadi, R.R., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Idrus, M.F., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Yusra, Y., Department of Clinical Pathology, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region Jakarta, Indonesia; Meilany, S., Research Center for Virology and Cancer Pathobiology, University of Indonesia Faculty of Medicine, Jakarta, Special Capital Region of Jakarta, Indonesia; Surandy, A., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Shatri, H., Psychosomatic and Palliative Care Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Special Capital Region of Jakarta, Central Jakarta, Indonesia; Rinaldi, I., Hematology and Medical Oncology Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Pitoyo, C.W., Respirology and Critical Care Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Renaldi, K., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia |
Objective This study will test the performance of the anal swab PCR test when compared with the nasopharyngeal swab PCR test as a diagnostic tool for COVID-19. Design An observational descriptive study which included hospitalised suspected, or probable cases of hopitalised COVID-19 patients, conducted in Dr. Cipto Mangunkusumo National Hospital, Ciputra Hospital, Mitra Keluarga Depok Hospital and Mitra Keluarga Kelapa Gading Hospital, Indonesia. Epidemiological, clinical, laboratory and radiology data were obtained. Nasopharyngeal and anal swabs specimens were collected for SARS-CoV-2 RNA detection. Results We analysed 136 subjects as part of this study. The clinical spectrum of COVID-19 manifesation in this study was typical of hospitalised patients, with 25% classified as mild cases, 14.7% in severe condition and 12.5% of subjects classified as having acute respiratory distress syndrome. When compared with nasopharyngeal swab as the standard specimen for reverse transcription polymerase chain reaction (RT-PCR) detection of SARS-CoV-2 antigen, the sensitivity and specificity of the anal swab was 36.7% and 93.8%, respectively. The positive and negative predictive value were 97.8% and 16.5 %, respectively. The performance of the anal swab remained similar when only the subgroup of patients with gastrointestinal symptoms (n=92, 67.6%) was analysed (sensitivity 40% and specificity 91.7%). Out of all the subjects included in analysis, 67.6% had gastrointestinal symptoms. Similarly, 73.3% of patients in the anal swab-positive group had gastrointestinal symptoms. The two most common gastrointestinal symptoms in the subjects' population were nausea and anorexia. Conclusion Anal swab specimen has low sensitivity (36.7%) but high specificity (93.8%) for detecting SARS-CoV-2 antigen by RT-PCR. Only one additional positive result was found by anal swab among the nasopharyngeal swab-negative group. Anal swab may not be needed as an additional test at the beginning of a patient's diagnostic investigation and nasopharyngeal swab RT-PCR remains as the standard diagnostic test for COVID-19. © 2020 American Society of Mechanical Engineers (ASME). All rights reserved. |
anal; COVID-19; diagnostic virology |
abdominal pain; adult; adult respiratory distress syndrome; anal swab; anorexia; Article; body mass; clinical laboratory; controlled study; coronavirus disease 2019; coughing; COVID-19 testing; current smoker; diagnostic test accuracy study; diarrhea; ex-smoker; female; fever; gastrointestinal symptom; headache; heart disease; hospital patient; human; hypertension; Indonesian; lung disease; major clinical study; malaise; male; mortality rate; nasopharyngeal swab; nausea; non insulin dependent diabetes mellitus; practice guideline; predictive value; priority journal; respiratory tract infection; reverse transcription polymerase chain reaction; sensitivity and specificity; sore throat |
BMJ Publishing Group |
20544774 |
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Article |
Q1 |
1240 |
3126 |
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396 |
Raharjo S.B., Chandranegara A.F., Hanafy D.A., Yamin M., Rasyid H.E., Haryadi, Rizal A., Ardhianto P., Hermanto D.Y., Yuniadi Y., OneAF Investigators |
57017880700;57224571328;55431326800;23475706300;57224560676;57224559936;57218771291;57208782791;57223816091;57155066100; |
Indonesian registry on atrial fibrillation (OneAF) |
2021 |
Medicine |
100 |
19 |
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e25725 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107981983&doi=10.1097%2fMD.0000000000025725&partnerID=40&md5=c16e93c69fd23a59227c9462d518a9c8 |
Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita; Pasar Rebo General Hospital; Department of Internal Medicine Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General HospitalJakarta, Indonesia; Department of Cardiology, Faculty of Medicine, alas University, Djamil General Hospital, Padang, West Sumatra, Indonesia; Eka Hospital, Pekanbaru, Riau, Indonesia; Department of Cardiology, Faculty of Medicine, Brawijaya University, Syaiful Anwar General Hospital, Malang, Indonesia; Department of Cardiology, Faculty of Medicine, Diponegoro University, Kariadi General Hospital, Semarang, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan KitaJakarta, Indonesia |
Raharjo, S.B., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita; Chandranegara, A.F., Pasar Rebo General Hospital; Hanafy, D.A., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita; Yamin, M., Department of Internal Medicine Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General HospitalJakarta, Indonesia; Rasyid, H.E., Department of Cardiology, Faculty of Medicine, alas University, Djamil General Hospital, Padang, West Sumatra, Indonesia; Haryadi, Eka Hospital, Pekanbaru, Riau, Indonesia; Rizal, A., Department of Cardiology, Faculty of Medicine, Brawijaya University, Syaiful Anwar General Hospital, Malang, Indonesia; Ardhianto, P., Department of Cardiology, Faculty of Medicine, Diponegoro University, Kariadi General Hospital, Semarang, Indonesia; Hermanto, D.Y., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan KitaJakarta, Indonesia; Yuniadi, Y., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan KitaJakarta, Indonesia; OneAF Investigators |
BACKGROUND: Data on the optimal therapeutic international normalized ratio (INR) for non-valvular and valvular atrial fibrillation (AF) in Indonesia is currently unavailable. Therefore, we designed the Indonesian Registry on Atrial Fibrillation (OneAF) registry in order to seek a safe and beneficial range of INR in Indonesian patients with non-valvular and valvular AF. METHODS/DESIGN: The OneAF registry is a nationwide collaboration of the Indonesian Heart Rhythm Society (InaHRS) enrolling all hospitals with cardiac electrophysiologists in Indonesia. It is a prospective, multicentre, nationwide, observational study aiming to recruit non-valvular and valvular AF patients in Indonesia. The registry was started in January 2020 with a planned 2 years of recruitment. There are 2 respondents for this registry: non-cohort and cohort respondents. Non-cohort registry respondents are AF patients at hospitals who fulfill inclusion and exclusion criteria but did not consent for a 24 month follow up. Whereas patients who consented for a 24 month follow up were included as cohort registry respondents. Key data collected includes basic sociodemographic information, symptoms and signs, medical history, results of physical examination and laboratory test, details of diagnostics and treatment measures and events. RESULTS: Currently, a total of 1568 respondents have been enrolled in the non-cohort registry, including 1065 respondents with non-valvular AF (67.8%) and 503 respondents with valvular AF (32.2%). We believe that the OneAF registry will provide insight into the regional variability of anticoagulant treatment for AF, the implementation of rhythm/rate control approaches, and the clinical outcomes concerning cardiocerebrovascular events. TRIAL REGISTRATION: Registered at clinicaltrials.gov (NCT04222868). Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. |
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adolescent; adult; aged; atrial fibrillation; clinical trial; female; human; Indonesia; male; middle aged; multicenter study; prospective study; register; very elderly; young adult; Adolescent; Adult; Aged; Aged, 80 and over; Atrial Fibrillation; Female; Humans; Indonesia; Male; Middle Aged; Prospective Studies; Registries; Young Adult |
NLM (Medline) |
15365964 |
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34106597 |
Article |
Q4 |
204 |
19087 |
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397 |
Siste K., Hanafi E., Sen L.T., Murtani B.J., Christian H., Limawan A.P., Siswidiani L.P., Adrian |
55644113100;56737010600;57219034101;57216652176;57209266195;57202712511;57219029296;57216932703; |
Implications of COVID-19 and Lockdown on Internet Addiction Among Adolescents: Data From a Developing Country |
2021 |
Frontiers in Psychiatry |
12 |
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665675 |
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6 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107077623&doi=10.3389%2ffpsyt.2021.665675&partnerID=40&md5=19567c64b9f1c1b25ae702d165f6737d |
Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Siste, K., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Hanafi, E., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Sen, L.T., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Murtani, B.J., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Christian, H., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Limawan, A.P., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Siswidiani, L.P., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Adrian, Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Introduction: Physical distancing policy during coronavirus disease 2019 (COVID-19) pandemic requires adolescents to spend most of their time at home, thus increasing Internet use duration. Limited social interaction with their peers may lead to loneliness and an increased risk of mental health among adolescents. This study aimed to assess the prevalence of Internet addiction (IA) among adolescents and analyze the influence of psychosocial factors toward the heightened risk of IA during the COVID-19 pandemic. Methods: An online survey comprising sociodemographic questionnaire, Internet Addiction Diagnostic Questionnaire (KDAI), Strengths and Difficulties Questionnaire (SDQ), and Pittsburgh Sleep Quality Index (PSQI) was distributed. Overall, a total of 2,932 adolescents (mean age, 17.38 ± 2.24 years old; female, 78.7%), originating from 33 of 34 provinces in Indonesia, completed the survey. Results: The point prevalence of IA among Indonesian adolescents during the COVID-19 outbreak was 19.3%. Increased Internet use duration, internalization, externalization, low prosocial behavior, and sleep disturbances were found as risk factors of IA, either directly or as mediating variables. Physical distancing, large-scale social restriction (PSBB), and health status were not correlated to IA. Discussion: Physical distancing was not established as a risk of IA. This could be due to other psychological factors such as internalization, externalization, prosocial, and sleep problems that had correlations to IA occurrence among adolescents in the COVID-19 pandemic. Sleep impairment might have resulted from the emotional and behavioral issues and directly contributed to IA development. Conclusion: The present study found the prevalence of IA among Indonesian adolescents to be higher than the adult during the COVID-19 pandemic. Several psychological measures were indicated to increase the risk of IA, while physical distancing did not elevate the risk. Thus, remote schooling is preferable in Indonesia along with proper parental supervision to minimize Internet use for entertainment purposes. © Copyright © 2021 Siste, Hanafi, Sen, Murtani, Christian, Limawan, Siswidiani and Adrian. |
adolescents; coronavirus disease 2019; Indonesia; internet addiction; lockdown; physical distancing; psychopathology; sleep quality |
adolescent; adolescent disease; age distribution; Article; behavior disorder; controlled study; coronavirus disease 2019; demography; developing country; emotional disorder; externalization (behavior); female; health status; health survey; human; Indonesia; Indonesian; internalization (behavior); internet addiction; Internet Addiction Diagnostic Questionnaire; major clinical study; male; national lockdown; pandemic; Pittsburgh Sleep Quality Index; prevalence; prosocial behavior; psychological aspect; questionnaire; risk assessment; sex ratio; sleep disorder; social aspect; social distancing; social psychology; strengths and difficulties questionnaire |
Frontiers Media S.A. |
16640640 |
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Article |
Q1 |
1363 |
2668 |
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400 |
Han W.M., Jiamsakul A., Salleh N.A.M., Choi J.Y., Huy B.V., Yunihastuti E., Do C.D., Merati T.P., Gani Y.M., Kiertiburanakul S., Zhang F., Chan Y.-J., Lee M.-P., Chaiwarith R., Ng O.T., Khusuwan S., Ditangco R., Kumarasamy N., Sangle S., Ross J., Avihingsanon A., Ly P.S., Khol V., Zhang F.J., Zhao H.X., Han N., Lee M.P., Li P.C.K., Lam W., Chan Y.T., Kumarasamy N., Ezhilarasi C., Pujari S., Joshi K., Gaikwad S., Chitalikar A., Sangle S., Mave V., Marbaniang I., Nimkar S., Merati T.P., Wirawan D.N., Yuliana F., Yunihastuti E., Widhani A., Maria S., Karjadi T.H., Tanuma J., Oka S., Nishijima T., Choi J.Y., Na S., Kim J.M., Gani Y.M., Rudi N.B., Azwa I., Kamarulzaman A., Syed Omar S.F., Ponnampalavanar S., Ditangco R., Pasayan M.K., Mationg M.L., Chan Y.J., Ku W.W., Wu P.C., Ke E., Ng O.T., Lim P.L., Lee L.S., Liang D., Avihingsanon A., Gatechompol S., Phanuphak P., Phadungphon C., Phuphuakrat A., Chumla L., Sanmeema N., Chaiwarith R., Sirisanthana T., Praparattanapan J., Nuket K., Khusuwan S., Kantipong P., Kambua P., Nguyen K.V., Bui H.V., Nguyen D.T.H., Nguyen D.T., Do C.D., Ngo A.V., Nguyen L.T., Sohn A.H., Ross J.L., Petersen B., Law M.G., Jiamsakul A., Bijker R., Rupasinghe D., TREAT Asia HIV Observational Database (TAHOD) of the International Epidemiology Databases to Evaluate AIDS (IeDEA) Asia-Pacific Group |
57201984684;55285745500;57209499322;48761023600;55757403300;57221273925;55035577700;8935806500;57188842533;6506539792;23007277900;57258255400;57309539000;13806165200;57215769524;56166613100;55406840800;7003549856;6602877716;57193109926;57196347321;57204852770;57188842644;55503803800;35796801900;57206253688;56143671100;57203375227;57188836039;57188839065;55412491000;55413091200;57205894660;35227451500;55273903300;57188839029;57257928100;24778446900;57189801547;56820043000;57203678680;6601921496;57202976978;8850357600;57202561455;57213345044;57219422563;57208428839;57202558648;57226409961;57294788000;14037572300;7601387767;57188842533;57257789600;55553159100;6603019663;55295731300;36768852500;57258598000;57207954173;36936083900;33667461800;55856943500;56514424400;57257813200;57203665233;10041498300;55992506400;57258040600;57200282477;57193906863;7004982661;56015716600;8277552900;56515326900;55992497800;57203665049;7004277229;35185428900;57192871045;56166613100;6603580797;55285745100;56370854300;56498653200;56970337500;57190300831;56658396600;57208054163;41961438300;7006405275;57217343074;56406054800;55556254800;55285745500;57188697907;57205313395; |
HIV treatment outcomes among people who acquired HIV via injecting drug use in the Asia-Pacific region: a longitudinal cohort study |
2021 |
Journal of the International AIDS Society |
24 |
5 |
e25736 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106697623&doi=10.1002%2fjia2.25736&partnerID=40&md5=5b62ec1b7839280e4b8e69702122c64a |
Kirby Institute, UNSW, Sydney, Australia; HIV-NAT, Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Centre of Excellence for Research in AIDS (CERiA), University of Malaya, Kuala Lumpur, Malaysia; Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; National Hospital for Tropical Diseases, Hanoi, Viet Nam; Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Bach Mai Hospital, Hanoi, Viet Nam; Faculty of Medicine, Udayana University & Sanglah Hospital, Bali, Indonesia; Hospital Sungai Buloh, Sungai Buloh, Malaysia; Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Beijing Ditan Hospital, Capital Medical University, Beijing, China; Taipei Veterans General Hospital, Taipei, Taiwan; Queen Elizabeth Hospital, Hong Kong; Research Institute for Health Sciences, Chiang Mai, Thailand; Tan Tock Seng Hospital, Tan Tock Seng, Singapore; Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; Research Institute for Tropical Medicine, Muntinlupa City, Philippines; Chennai Antiviral Research and Treatment Clinical Research Site (CART CRS), VHS-Infectious Diseases Medical Centre, VHSChennai, India; BJ Government Medical College and Sassoon General Hospital, Pune, India; TREAT Asia, amfAR - The Foundation for AIDS Research, Bangkok, Thailand; Tuberculosis Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; National Center for HIV/AIDS, Dermatology & STDs, Phnom Penh, Cambodia; Beijing Ditan Hospital, Capital Medical University, Beijing, China; Queen Elizabeth Hospital, Hong Kong; Chennai Antiviral Research and Treatment Clinical Research Site (CART CRS), VHS-Infectious Diseases Medical Centre, VHS, Chennai, India; Institute of Infectious Diseases, Pune, India; BJ Government Medical College and Sassoon General Hospital, Pune, India; Faculty of Medicine Udayana University & Sanglah Hospital, Bali, Indonesia; Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; National Center for Global Health and Medicine, Tokyo, Japan; Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Hospital Sungai Buloh, Sungai Buloh, Malaysia; University Malaya Medical Centre, Kuala Lumpur, Malaysia; Research Institute for Tropical Medicine, Muntinlupa City, Philippines; Taipei Veterans General Hospital, Taipei, Taiwan; Tan Tock Seng Hospital, Singapore; HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Research Institute for Health Sciences, Chiang Mai, Thailand; Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; National Hospital for Tropical Diseases, Hanoi, Viet Nam; Bach Mai Hospital, Hanoi, Viet Nam; TREAT Asia, amfAR - The Foundation for AIDS Research, Bangkok, Thailand; The Kirby Institute, UNSW SydneyNSW, Australia |
Han, W.M., Kirby Institute, UNSW, Sydney, Australia, HIV-NAT, Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Jiamsakul, A., Kirby Institute, UNSW, Sydney, Australia, The Kirby Institute, UNSW SydneyNSW, Australia; Salleh, N.A.M., Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia, Centre of Excellence for Research in AIDS (CERiA), University of Malaya, Kuala Lumpur, Malaysia; Choi, J.Y., Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Huy, B.V., National Hospital for Tropical Diseases, Hanoi, Viet Nam; Yunihastuti, E., Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Do, C.D., Bach Mai Hospital, Hanoi, Viet Nam; Merati, T.P., Faculty of Medicine, Udayana University & Sanglah Hospital, Bali, Indonesia; Gani, Y.M., Hospital Sungai Buloh, Sungai Buloh, Malaysia, Hospital Sungai Buloh, Sungai Buloh, Malaysia; Kiertiburanakul, S., Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Zhang, F., Beijing Ditan Hospital, Capital Medical University, Beijing, China; Chan, Y.-J., Taipei Veterans General Hospital, Taipei, Taiwan; Lee, M.-P., Queen Elizabeth Hospital, Hong Kong; Chaiwarith, R., Research Institute for Health Sciences, Chiang Mai, Thailand; Ng, O.T., Tan Tock Seng Hospital, Tan Tock Seng, Singapore; Khusuwan, S., Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand, Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; Ditangco, R., Research Institute for Tropical Medicine, Muntinlupa City, Philippines; Kumarasamy, N., Chennai Antiviral Research and Treatment Clinical Research Site (CART CRS), VHS-Infectious Diseases Medical Centre, VHSChennai, India; Sangle, S., BJ Government Medical College and Sassoon General Hospital, Pune, India; Ross, J., TREAT Asia, amfAR - The Foundation for AIDS Research, Bangkok, Thailand; Avihingsanon, A., HIV-NAT, Thai Red Cross AIDS Research Centre, Bangkok, Thailand, Tuberculosis Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Ly, P.S., National Center for HIV/AIDS, Dermatology & STDs, Phnom Penh, Cambodia; Khol, V., National Center for HIV/AIDS, Dermatology & STDs, Phnom Penh, Cambodia; Zhang, F.J., Beijing Ditan Hospital, Capital Medical University, Beijing, China; Zhao, H.X., Beijing Ditan Hospital, Capital Medical University, Beijing, China; Han, N., Beijing Ditan Hospital, Capital Medical University, Beijing, China; Lee, M.P., Queen Elizabeth Hospital, Hong Kong; Li, P.C.K., Queen Elizabeth Hospital, Hong Kong; Lam, W., Queen Elizabeth Hospital, Hong Kong; Chan, Y.T., Queen Elizabeth Hospital, Hong Kong; Kumarasamy, N., Chennai Antiviral Research and Treatment Clinical Research Site (CART CRS), VHS-Infectious Diseases Medical Centre, VHS, Chennai, India; Ezhilarasi, C., Chennai Antiviral Research and Treatment Clinical Research Site (CART CRS), VHS-Infectious Diseases Medical Centre, VHS, Chennai, India; Pujari, S., Institute of Infectious Diseases, Pune, India; Joshi, K., Institute of Infectious Diseases, Pune, India; Gaikwad, S., Institute of Infectious Diseases, Pune, India; Chitalikar, A., Institute of Infectious Diseases, Pune, India; Sangle, S., BJ Government Medical College and Sassoon General Hospital, Pune, India; Mave, V., BJ Government Medical College and Sassoon General Hospital, Pune, India; Marbaniang, I., BJ Government Medical College and Sassoon General Hospital, Pune, India; Nimkar, S., BJ Government Medical College and Sassoon General Hospital, Pune, India; Merati, T.P., Faculty of Medicine Udayana University & Sanglah Hospital, Bali, Indonesia; Wirawan, D.N., Faculty of Medicine Udayana University & Sanglah Hospital, Bali, Indonesia; Yuliana, F., Faculty of Medicine Udayana University & Sanglah Hospital, Bali, Indonesia; Yunihastuti, E., Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Widhani, A., Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Maria, S., Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Karjadi, T.H., Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Tanuma, J., National Center for Global Health and Medicine, Tokyo, Japan; Oka, S., National Center for Global Health and Medicine, Tokyo, Japan; Nishijima, T., National Center for Global Health and Medicine, Tokyo, Japan; Choi, J.Y., Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Na, S., Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Kim, J.M., Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Gani, Y.M., Hospital Sungai Buloh, Sungai Buloh, Malaysia, Hospital Sungai Buloh, Sungai Buloh, Malaysia; Rudi, N.B., Hospital Sungai Buloh, Sungai Buloh, Malaysia; Azwa, I., University Malaya Medical Centre, Kuala Lumpur, Malaysia; Kamarulzaman, A., University Malaya Medical Centre, Kuala Lumpur, Malaysia; Syed Omar, S.F., University Malaya Medical Centre, Kuala Lumpur, Malaysia; Ponnampalavanar, S., University Malaya Medical Centre, Kuala Lumpur, Malaysia; Ditangco, R., Research Institute for Tropical Medicine, Muntinlupa City, Philippines; Pasayan, M.K., Research Institute for Tropical Medicine, Muntinlupa City, Philippines; Mationg, M.L., Research Institute for Tropical Medicine, Muntinlupa City, Philippines; Chan, Y.J., Taipei Veterans General Hospital, Taipei, Taiwan; Ku, W.W., Taipei Veterans General Hospital, Taipei, Taiwan; Wu, P.C., Taipei Veterans General Hospital, Taipei, Taiwan; Ke, E., Taipei Veterans General Hospital, Taipei, Taiwan; Ng, O.T., Tan Tock Seng Hospital, Singapore; Lim, P.L., Tan Tock Seng Hospital, Singapore; Lee, L.S., Tan Tock Seng Hospital, Singapore; Liang, D., Tan Tock Seng Hospital, Singapore; Avihingsanon, A., HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Gatechompol, S., HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Phanuphak, P., HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Phadungphon, C., HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Phuphuakrat, A., Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Chumla, L., Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Sanmeema, N., Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Chaiwarith, R., Research Institute for Health Sciences, Chiang Mai, Thailand; Sirisanthana, T., Research Institute for Health Sciences, Chiang Mai, Thailand; Praparattanapan, J., Research Institute for Health Sciences, Chiang Mai, Thailand; Nuket, K., Research Institute for Health Sciences, Chiang Mai, Thailand; Khusuwan, S., Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand, Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; Kantipong, P., Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; Kambua, P., Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; Nguyen, K.V., National Hospital for Tropical Diseases, Hanoi, Viet Nam; Bui, H.V., National Hospital for Tropical Diseases, Hanoi, Viet Nam; Nguyen, D.T.H., National Hospital for Tropical Diseases, Hanoi, Viet Nam; Nguyen, D.T., National Hospital for Tropical Diseases, Hanoi, Viet Nam; Do, C.D., Bach Mai Hospital, Hanoi, Viet Nam; Ngo, A.V., Bach Mai Hospital, Hanoi, Viet Nam; Nguyen, L.T., Bach Mai Hospital, Hanoi, Viet Nam; Sohn, A.H., TREAT Asia, amfAR - The Foundation for AIDS Research, Bangkok, Thailand; Ross, J.L., TREAT Asia, amfAR - The Foundation for AIDS Research, Bangkok, Thailand; Petersen, B., TREAT Asia, amfAR - The Foundation for AIDS Research, Bangkok, Thailand; Law, M.G., The Kirby Institute, UNSW SydneyNSW, Australia; Jiamsakul, A., Kirby Institute, UNSW, Sydney, Australia, The Kirby Institute, UNSW SydneyNSW, Australia; Bijker, R., The Kirby Institute, UNSW SydneyNSW, Australia; Rupasinghe, D., The Kirby Institute, UNSW SydneyNSW, Australia; TREAT Asia HIV Observational Database (TAHOD) of the International Epidemiology Databases to Evaluate AIDS (IeDEA) Asia-Pacific Group |
INTRODUCTION: Data on HIV treatment outcomes in people who inject drugs (PWID) in the Asia-Pacific are sparse despite the high burden of drug use. We assessed immunological and virological responses, AIDS-defining events and mortality among PWID receiving antiretroviral therapy (ART). METHODS: We investigated HIV treatment outcomes among people who acquired HIV via injecting drug use in the TREAT Asia HIV Observational Database (TAHOD) between January 2003 and March 2019. Trends in CD4 count and viral suppression (VS, HIV viral load <1000 copies/mL) were assessed. Factors associated with mean CD4 changes were analysed using repeated measures linear regression, and combined AIDS event and mortality were analysed using survival analysis. RESULTS: Of 622 PWID from 12 countries in the Asia-Pacific, 93% were male and the median age at ART initiation was 31 years (IQR, 28 to 34). The median pre-ART CD4 count was 71 cells/µL. CD4 counts increased over time, with a mean difference of 401 (95% CI, 372 to 457) cells/µL at year-10 (n = 78). Higher follow-up HIV viral load and pre-ART CD4 counts were associated with smaller increases in CD4 counts. Among 361 PWID with ≥1 viral load after six months on ART, proportions with VS were 82%, 88% and 93% at 2-, 5- and 10-years following ART initiation. There were 52 new AIDS-defining events and 50 deaths during 3347 person-years of follow-up (PYS) (incidence 3.05/100 PYS, 95% CI, 2.51 to 3.70). Previous AIDS or TB diagnosis, lower current CD4 count and adherence <95% were associated with combined new AIDS-defining event and death. CONCLUSIONS: Despite improved outcomes over time, our findings highlight the need for rapid ART initiation and adherence support among PWID within Asian settings. © 2021 The Authors. Journal of the International AIDS Society published by John Wiley & Sons Ltd on behalf of the International AIDS Society. |
Asia-Pacific; CD4 recovery; HIV/AIDS; people who inject drugs; treatment outcomes; tuberculosis; viral suppression |
nonnucleoside reverse transcriptase inhibitor; proteinase inhibitor; anti human immunodeficiency virus agent; drug; acquired immune deficiency syndrome; adult; all cause mortality; antiretroviral therapy; Article; Asia; CD4 lymphocyte count; cohort analysis; coinfection; female; follow up; hepatitis B; hepatitis C; human; Human immunodeficiency virus; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; incidence; injection drug user; longitudinal study; major clinical study; male; survival analysis; treatment outcome; tuberculosis; virus load; Human immunodeficiency virus infection; treatment outcome; Anti-HIV Agents; Asia; CD4 Lymphocyte Count; Cohort Studies; HIV Infections; Humans; Longitudinal Studies; Male; Pharmaceutical Preparations; Treatment Outc |
John Wiley and Sons Inc |
17582652 |
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34021711 |
Article |
Q1 |
2724 |
762 |
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401 |
Safari D., Gultom S.M., Tafroji W., Azzahidah A., Soesanti F., Khoeri M.M., Prayitno A., Pimenta F.C., da Gloria Carvalho M., Uiterwaal C.S.P.M., Putri N.D. |
23493586700;57223995277;57118271600;57223997121;37068080600;55994827400;57193342301;6603696480;55189494500;7006033434;57200573842; |
Prevalence, serotype and antibiotic susceptibility of Group B Streptococcus isolated from pregnant women in Jakarta, Indonesia |
2021 |
PLoS ONE |
16 |
5 May |
e0252328 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106668508&doi=10.1371%2fjournal.pone.0252328&partnerID=40&md5=d5ae48dcce9738619d131a8193789686 |
Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Faculty of Medicine, Department of Child Health, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Aix-Marseille University, Marseille, France; Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States; Julius Center for Health Sciences and Primary Care, Julius Global Health, University Medical Center, Utrecht, Netherlands |
Safari, D., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Gultom, S.M., Faculty of Medicine, Department of Child Health, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Tafroji, W., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Azzahidah, A., Aix-Marseille University, Marseille, France; Soesanti, F., Faculty of Medicine, Department of Child Health, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Khoeri, M.M., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Prayitno, A., Faculty of Medicine, Department of Child Health, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Pimenta, F.C., Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States; da Gloria Carvalho, M., Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States; Uiterwaal, C.S.P.M., Julius Center for Health Sciences and Primary Care, Julius Global Health, University Medical Center, Utrecht, Netherlands; Putri, N.D., Faculty of Medicine, Department of Child Health, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Group B Streptococcus (GBS) is a bacterial pathogen which is a leading cause of neonatal infection. Currently, there are limited GBS data available from the Indonesian population. In this study, GBS colonization, serotype distribution and antimicrobial susceptibility profile of isolates were investigated among pregnant women in Jakarta, Indonesia. Demographics data, clinical characteristics and vaginal swabs were collected from 177 pregnant women (mean aged: 28.7 years old) at 29–40 weeks of gestation. Bacterial culture identification tests and latex agglutination were performed for GBS. Serotyping was done by conventional multiplex PCR and antibiotic susceptibility testing by broth microdilution. GBS colonization was found in 53 (30%) pregnant women. Serotype II was the most common serotype (30%) followed by serotype III (23%), Ia and IV (13% each), VI (8%), Ib and V (6% each), and one non-typeable strain. All isolates were susceptible to vancomycin, penicillin, ampicillin, cefotaxime, daptomycin and linezolid. The majority of GBS were resistant to tetracycline (89%) followed by clindamycin (21%), erythromycin (19%), and levofloxacin (6%). The serotype III was more resistant to erythromycin, clindamycin, and levofloxacin and these isolates were more likely to be multidrug resistant (6 out of 10) compared to other serotypes. This report provides demographics of GBS colonization and isolate characterization in pregnant women in Indonesia. The results may facilitate preventive strategies to reduce neonatal GBS infection and improve its treatment. Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. |
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ampicillin; cefotaxime; cefoxitin; ceftizoxime; ciprofloxacin; clindamycin; daptomycin; erythromycin; levofloxacin; linezolid; penicillin derivative; tetracycline; vancomycin; adolescent; adult; antibiotic resistance; antibiotic sensitivity; Article; bacterial colonization; bacterium culture; bacterium identification; bacterium isolate; broth dilution; controlled study; female; gestation period; group B streptococcal infection; human; Indonesia; latex agglutination test; major clinical study; multidrug resistance; multiplex polymerase chain reaction; nonhuman; pregnancy; prevalence; serotype; Streptococcus agalactiae; vagina smear; antibiotic resistance; isolation and purification; pregnancy; pregnancy complication; Streptococcus agalactiae; Streptococcus infection; young adult; Adolescent |
Public Library of Science |
19326203 |
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34043711 |
Article |
Q1 |
990 |
4434 |
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402 |
van Crevel R., Avila-Pacheco J., Thuong N.T.T., Ganiem A.R., Imran D., Hamers R.L., Alisjahbana B., Dian S., Estiasari R., Tram T.T.B., Vinh D.N., Hai H.T., Donovan J., Ardiansyah E., Koeken V., Kumar V., Netea M.G., van Laarhoven A., Clish C., Thwaites G., The ULTIMATE consortium |
6603956378;57194750113;16551464800;35145741500;57203976849;23034345900;6506944516;55418398700;55240204000;56426109200;56562746100;57197774138;57203943392;57205617822;57194441324;57222877712;35378641700;55625910500;35460787900;57220045286; |
Improving host-directed therapy for tuberculous meningitis by linking clinical and multi-omics data |
2021 |
Tuberculosis |
128 |
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102085 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106295161&doi=10.1016%2fj.tube.2021.102085&partnerID=40&md5=4ce0f74084aad8c1c23b99ba0823c3f8 |
Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; The Broad Institute of MIT and Harvard, Cambridge, MA, United States; Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; TB-HIV Research Center, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Eijkman Oxford Clinical Research Unit, Jakarta, Indonesia |
van Crevel, R., Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Avila-Pacheco, J., The Broad Institute of MIT and Harvard, Cambridge, MA, United States; Thuong, N.T.T., Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Ganiem, A.R., TB-HIV Research Center, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Imran, D., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hamers, R.L., Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Eijkman Oxford Clinical Research Unit, Jakarta, Indonesia; Alisjahbana, B., TB-HIV Research Center, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Dian, S., TB-HIV Research Center, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Estiasari, R., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tram, T.T.B., Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Vinh, D.N., Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Hai, H.T., Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Donovan, J., Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Ardiansyah, E., Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Koeken, V., Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands; Kumar, V., Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands; Netea, M.G., Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands; van Laarhoven, A., Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands; Clish, C., The Broad Institute of MIT and Harvard, Cambridge, MA, United States; Thwaites, G., Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; The ULTIMATE consortium |
There is a clear need to improve host-directed therapy for tuberculous meningitis (TBM), the most severe and deadly manifestation of tuberculosis. Corticosteroids represent the only host-directed therapy of proven benefit in TBM, yet their effect is modest, the mechanism by which they reduce mortality is unknown, and there is evidence for heterogeneity in their effect. Novel therapeutic approaches are therefore urgently needed. Cellular metabolism is critical for the function of immune cells; through unbiased metabolomics we recently found that high concentrations of cerebrospinal fluid (CSF) tryptophan are associated with increased mortality in Indonesian TBM patients, and that CSF tryptophan concentrations are under strong genetic regulation. Many questions remain. How exactly is tryptophan metabolism altered during TBM? How does it correlate with inflammation, immunopathology, and response to corticosteroids? How is tryptophan metabolism genetically regulated? What is the effect of HIV co-infection on tryptophan metabolism before and during TBM treatment? The ULTIMATE project addresses these questions by integrating data and specimens from large patient studies and clinical trials evaluating the effects of corticosteroids in Vietnam and Indonesia. Through its powerful and unbiased approach, ULTIMATE aims to identify which TBM patients benefit from corticosteroids and if novel therapeutic targets, such as the tryptophan pathway, could be targeted. © 2021 |
Cerebrospinal fluid; Genetics; Host-directed therapy; Meningitis; Metabolomics; Tryptophan; Tuberculosis |
corticosteroid; tryptophan; corticosteroid; tryptophan; tuberculostatic agent; Article; cerebrospinal fluid level; clinical trial (topic); coinfection; corticosteroid therapy; genetic regulation; host-directed therapy; human; Human immunodeficiency virus infection; multiomics; nonhuman; pathogenesis; priority journal; treatment response; tryptophan metabolism; tuberculous meningitis; cerebrospinal fluid; metabolomics; mortality; tuberculous meningitis; Adrenal Cortex Hormones; Antitubercular Agents; Humans; Metabolomics; Tryptophan; Tuberculosis, Meningeal |
Churchill Livingstone |
14729792 |
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34022506 |
Article |
Q2 |
977 |
4524 |
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403 |
Fuady A., Nuraini N., Sukandar K.K., Lestari B.W. |
37085331400;24605696400;57216947725;56589945500; |
Targeted vaccine allocation could increase the covid-19 vaccine benefits amidst its lack of availability: A mathematical modeling study in indonesia |
2021 |
Vaccines |
9 |
5 |
462 |
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9 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105974918&doi=10.3390%2fvaccines9050462&partnerID=40&md5=4a9375c9281f8f4834500172552d5373 |
Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10310, Indonesia; Department of Public Health, Erasmus MC University Medical Center Rotterdam, Rotterdam, 3015 GD, Netherlands; Department of Mathematics, Institut Teknologi Bandung, Bandung, 40132, Indonesia; Epidemiology Group of COVID-19 Task Force for West Java, Bandung, 40171, Indonesia; Department of Public Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, 40161, Indonesia; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, 6525 GA, Netherlands |
Fuady, A., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10310, Indonesia, Department of Public Health, Erasmus MC University Medical Center Rotterdam, Rotterdam, 3015 GD, Netherlands; Nuraini, N., Department of Mathematics, Institut Teknologi Bandung, Bandung, 40132, Indonesia, Epidemiology Group of COVID-19 Task Force for West Java, Bandung, 40171, Indonesia; Sukandar, K.K., Department of Mathematics, Institut Teknologi Bandung, Bandung, 40132, Indonesia; Lestari, B.W., Epidemiology Group of COVID-19 Task Force for West Java, Bandung, 40171, Indonesia, Department of Public Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, 40161, Indonesia, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, 6525 GA, Netherlands |
With a limited number of vaccines and healthcare capacity shortages, particularly in low-and middle-income countries, vaccination programs should seek the most efficient strategy to reduce the negative impact of the COVID-19 pandemics. This study aims at assessing several scenarios of delivering the vaccine to people in Indonesia. We develop a model for several scenarios of delivering vaccines: without vaccination, fair distribution, and targeted distribution to five and eight districts with the highest COVID-19 incidence in West Java, one of the most COVID-19-affected regions in Indonesia. We calculate the needs of vaccines and healthcare staff for the program, then simulate the model for the initial 4-month and one-year scenarios. A one-year vaccination program would require 232,000 inoculations per day by 4833 vaccinators. Targeted vaccine allocation based on the burden of COVID-19 cases could benefit the COVID-19 vaccination program by lowering at least 5000 active cases. The benefits would increase by improving the number of vaccines and healthcare staff. Amidst lacking available vaccines, targeted vaccine allocation based on the burden of COVID-19 cases could increase the benefit of the COVID-19 vaccination program but still requires progressive efforts to improve healthcare capacity and vaccine availability for optimal protection for people. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
COVID-19; Low-and middle-income countries; Modeling; Strategy; Vaccine |
SARS-CoV-2 vaccine; Article; coronavirus disease 2019; disease model; disease predisposition; disease transmission; drug bioavailability; drug efficacy; health care need; health care personnel; human; Indonesia; infection rate; mathematical model; mortality; quarantine; reinfection; resource allocation; SIQRD model; vaccination |
MDPI AG |
2076393X |
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Article |
Q1 |
1296 |
2913 |
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404 |
Harbuwono D.S., Sazli B.I., Kurniawan F., Darmowidjojo B., Koesnoe S., Tahapary D.L. |
36056341600;57223390172;57202309006;57210642934;26028015000;55944492500; |
The impact of Ramadan fasting on Fetuin-A level in type 2 diabetes mellitus |
2021 |
Heliyon |
7 |
5 |
e06773 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105783321&doi=10.1016%2fj.heliyon.2021.e06773&partnerID=40&md5=2dd413b4d090b7268ec8e92f9121b6ce |
Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia; Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, Jakarta 10430, Indonesia; Division of Allergy and Immunology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia |
Harbuwono, D.S., Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia, Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, Jakarta 10430, Indonesia; Sazli, B.I., Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia, Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, Jakarta 10430, Indonesia; Kurniawan, F., Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia, Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, Jakarta 10430, Indonesia; Darmowidjojo, B., Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia, Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, Jakarta 10430, Indonesia; Koesnoe, S., Division of Allergy and Immunology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia; Tahapary, D.L., Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia, Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, Jakarta 10430, Indonesia |
Background/Aims: Ramadan fasting creates changes in lifestyle, causing biochemical alterations that affect glucose metabolism and insulin sensitivity. This study aims to assess the impact of Ramadan fasting on glycemic control and Fetuin-A, a glycoprotein that affects insulin resistance, in patients with type 2 diabetes mellitus (T2DM). Materials and methods: This was a prospective study done among 37 patients with T2DM from Internal Medicine Polyclinic in a hospital in Jakarta, Indonesia. Anthropometric data as well as Hemoglobin A1c (HbA1c), Fasting Blood Glucose (FBG), and Fetuin-A levels of the subjects were measured in three time points: before, during, and after Ramadan fasting. A bivariate analysis was done to see the effect of Ramadan fasting on those parameters. Results: Ramadan fasting reduced Fetuin-A levels [median (minimum–maximum), 5.35 (2.91–7.81) vs. 3.22 (2.35–5.60) mg/dl; p = 0.039] four weeks after the end of Ramadan compared to pre-Ramadan. After two weeks of Ramadan fasting, we found a significant reduction in body weight, BMI, FBG, and HbA1c levels which rebounded to baseline level after Ramadan. Conclusion: Ramadan fasting was associated with a significant decrease in Fetuin-A level post Ramadan. © 2021 The Authors |
Diabetes mellitus; Fetuin-A; Glycoprotein; Insulin resistance; Ramadan fasting |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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405 |
Sampurna M.T.A., Rohsiswatmo R., Primadi A., Wandita S., Sulistijono E., Bos A.F., Sauer P.J.J., Hulzebos C.V., Dijk P.H. |
57201733407;55533574600;8422152900;57194904658;57218101844;36839156800;57191375642;6603928053;6701798049; |
Corrigendum to “The knowledge of Indonesian pediatric residents on hyperbilirubinemia management” [Heliyon 7 (4) (2021) e06661](S2405844021007647)(10.1016/j.heliyon.2021.e06661) |
2021 |
Heliyon |
7 |
5 |
e07007 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105737450&doi=10.1016%2fj.heliyon.2021.e07007&partnerID=40&md5=f1c3a5a39332f7f89a1e521e66c2589f |
Neonatology Division, Department of Pediatrics, Airlangga University Teaching Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Neonatology Division, Department of Pediatrics, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pediatrics, Hasan Sadikin Hospital, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia; Neonatology Division, Department of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Department of Pediatrics, Saiful Anwar Hospital, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands |
Sampurna, M.T.A., Neonatology Division, Department of Pediatrics, Airlangga University Teaching Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Rohsiswatmo, R., Neonatology Division, Department of Pediatrics, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Primadi, A., Department of Pediatrics, Hasan Sadikin Hospital, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia; Wandita, S., Neonatology Division, Department of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Sulistijono, E., Department of Pediatrics, Saiful Anwar Hospital, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Bos, A.F., Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Sauer, P.J.J., Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Hulzebos, C.V., Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Dijk, P.H., Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands |
In the original published version of this article, the authors provided the incorrect institutional review board number, 1060/KEPK/III/2019. This has now been corrected to 390/Panke.KKE/V/2017. The authors apologise for this mistake. Both the HTML and PDF versions of the article have been updated to correct the error. © 2021 The Author(s) |
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Elsevier Ltd |
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Erratum |
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455 |
10919 |
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407 |
Atmoko W., Raharja P.A.R., Birowo P., Ardy A.R., Hamid H., Taher A., Rasyid N. |
57193125664;57201013616;6504153311;57223308079;57223278890;7005269743;56245069300; |
Genetic polymorphisms as prognostic factors for recurrent kidney stones: A systematic review and meta-analysis |
2021 |
PLoS ONE |
16 |
5 May |
e0251235 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105518414&doi=10.1371%2fjournal.pone.0251235&partnerID=40&md5=b6950d085d520fd3088636a18669e525 |
Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Atmoko, W., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Raharja, P.A.R., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Birowo, P., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ardy, A.R., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hamid, H., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Taher, A., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rasyid, N., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Genetic polymorphisms have been suggested as risk factors affecting the occurrence and recurrence of kidney stones, although findings regarding the latter remain inconclusive. We performed this systematic review and meta-analysis to clarify the associations between genetic polymorphisms and recurrent kidney stones. PubMed, SCOPUS, EMBASE, and Cochrane Library databases were searched through May 28th, 2020 to identify eligible studies. The Quality in prognostic studies (QUIPS) tool was used to evaluate bias risk. Allelic frequencies and different inheritance models were assessed. All analyses were performed using Review manager 5.4. A total of 14 studies were included for meta-analysis, assessing urokinase (ApaL1) and vitamin D receptor (VDR) (ApaI, BsmI, FokI, and TaqI) gene polymorphisms. The ApaLI polymorphism demonstrated protective association in the recessive model [odds ratio (OR) 0.45, P < 0.01] albeit higher risk among Caucasians in the heterozygous model (OR 16.03, P < 0.01). The VDR-ApaI polymorphism showed protective association in the dominant model (OR 0.60, P < 0.01). Among Asians, the VDR-FokI polymorphism recessive model showed significant positive association (OR 1.70, P < 0.01) and the VDR-TaqI polymorphism heterozygous model exhibited protective association (OR 0.72, P < 0.01). The VDR-BsmI polymorphism was not significantly associated with recurrent kidney stones in any model. Urokinase-ApaLI (recessive model), VDR-ApaI (dominant model), and VDR-TaqI (heterozygous model) polymorphisms were associated with decreased recurrent kidney stone risk whereas urokinase-ApaLI (heterozygous model) and VDR-FokI polymorphisms were associated with increased risk among Caucasians and Asians, respectively. These findings will assist in identifying individuals at risk of kidney stone recurrence. © 2021 Atmoko et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author andsource are credited. |
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urokinase; vitamin D receptor; ApaL1 gene; Asian; Caucasian; dominant inheritance; gene frequency; genetic association; genetic polymorphism; genetic variability; heterozygosity; high risk patient; human; nephrolithiasis; prognosis; protection; recessive inheritance; recurrence risk; Review; risk reduction; systematic review; VDR gene; genetic polymorphism; genetics; meta analysis; nephrolithiasis; prognosis; recurrent disease; Humans; Kidney Calculi; Polymorphism, Genetic; Prognosis; Recurrence |
Public Library of Science |
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