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375 |
Djusad S., Sari Y.M., Tjahjadi H. |
57192276788;57217020003;57210953454; |
Deep (aggressive) angiomyxoma of the vagina misdiagnosed as Gartner cyst: A case report |
2021 |
International Journal of Surgery Case Reports |
83 |
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105948 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105312488&doi=10.1016%2fj.ijscr.2021.105948&partnerID=40&md5=b18f961bc2c3f8c96cac7a019b1ba409 |
Urogynecology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Anatomic Pathology Department, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Djusad, S., Urogynecology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sari, Y.M., Urogynecology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Tjahjadi, H., Anatomic Pathology Department, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction and importance: Aggressive angiomyxoma is a rare soft tissue tumor. Aggressive angiomyxoma is a slow-growing vulvovaginal mesenchymal neoplasm with a marked tendency for local recurrence, but with a low tendency to metastasize. As it has a predilection for the pelvic and perineal regions, Aggressive angiomyxoma is often misdiagnosed. This case report documented rare case of misdiagnosed Aggressive Angiomyxoma as Gartner duct cyst. Presentation of case: This article report a case of 31 year old women who complained mass came out from vagina without any urinary symptom and trauma. Physical examination and ultrasound finding suggested that the mass was Gartner Duct cyst. Management in this case was excision of the vaginal cyst. Histopathology examination revealed Deep (aggressive) angiomyxoma. Discussion: The rarity of Deep (Aggressive) Angiomyxoma makes the preoperative diagnosis fairly difficult. Aggressive angiomyxoma is often misdiagnosed as it may have similar clinical presentation to common lesions such as Bartholin cyst or prolapse vaginal wall, Gartner cyst or levator hernia. Aggressive Angiomyxoma should be considered as differential diagnosis in patient with vaginal cyst. Conclusion: Aggressive Angiomyxoma is rare condition. Preoperative diagnosis and management are challenging. Long term follow op and evaluation should be done due to high rate of recurrence. © 2021 The Author(s) |
Case report; Deep (aggressive) angiomyxoma of the vagina; Misdiagnosed Gartner cyst; Misdiagnosis of vaginal tumor; Rare case |
desmin; estrogen receptor; progesterone receptor; smooth muscle actin; adult; Article; case report; clinical article; diagnostic error; differential diagnosis; excision; female; Gartner cyst; histopathology; human; human tissue; physical examination; priority journal; translabial ultrasound; vagina aggressive angiomyxoma; vagina mucosa; vagina tumor; vaginal cyst |
Elsevier Ltd |
22102612 |
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Article |
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232 |
17549 |
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378 |
Mori Y., Sato H., Kumazawa T., Mayang Permata T.B., Yoshimoto Y., Murata K., Noda S.-E., Kaminuma T., Ando K., Oike T., Okonogi N., Okada K., Kakoti S., Suzuki K., Ikota H., Yokoo H., Nakano T., Ohno T., Shibata A. |
57210846989;55697961900;57210432294;57197808751;36453407100;36103294900;14621772700;23994005700;55641963900;36453136000;36453127400;57222984111;57197814645;57376271900;57214213081;55588986400;35353843800;35395665700;8323572900; |
Analysis of radiotherapy-induced alteration of CD8+ T cells and PD-L1 expression in patients with uterine cervical squamous cell carcinoma |
2021 |
Oncology Letters |
21 |
6 |
446 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104336493&doi=10.3892%2fol.2021.12707&partnerID=40&md5=a047e0e92118f6cb0de5b48cfc613e96 |
Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, 371-8511, Japan; Department of Radiotherapy, Saitama Cancer Center, Ina, Saitama, 362-0806, Japan; Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Department of Radiation Oncology, Fukushima Medical University, Fukushima, 960-1247, Japan; Department of Radiation Oncology, Comprehensive Cancer Center, International Medical Center, Saitama Medical University, Hidaka, Saitama, 350-1298, Japan; National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba, 263-8555, Japan; Signal Transduction Program, Gunma University Initiative for Advanced Research, Gunma University, Maebashi, Gunma, 371-8511, Japan; Department of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, 852-8523, Japan; Clinical Department of Pathology, Gunma University Hospital, Maebashi, Gunma, 371-8511, Japan; Department of Human Pathology, Gunma University, Graduate School of Medicine, Maebashi, Gunma, 371-8511, Japan |
Mori, Y., Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, 371-8511, Japan, Department of Radiotherapy, Saitama Cancer Center, Ina, Saitama, 362-0806, Japan; Sato, H., Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, 371-8511, Japan; Kumazawa, T., Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, 371-8511, Japan; Mayang Permata, T.B., Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Yoshimoto, Y., Department of Radiation Oncology, Fukushima Medical University, Fukushima, 960-1247, Japan; Murata, K., Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, 371-8511, Japan; Noda, S.-E., Department of Radiation Oncology, Comprehensive Cancer Center, International Medical Center, Saitama Medical University, Hidaka, Saitama, 350-1298, Japan; Kaminuma, T., Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, 371-8511, Japan; Ando, K., Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, 371-8511, Japan; Oike, T., Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, 371-8511, Japan; Okonogi, N., National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba, 263-8555, Japan; Okada, K., Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, 371-8511, Japan; Kakoti, S., Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, 371-8511, Japan, Signal Transduction Program, Gunma University Initiative for Advanced Research, Gunma University, Maebashi, Gunma, 371-8511, Japan; Suzuki, K., Department of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, 852-8523, Japan; Ikota, H., Clinical Department of Pathology, Gunma University Hospital, Maebashi, Gunma, 371-8511, Japan; Yokoo, H., Department of Human Pathology, Gunma University, Graduate School of Medicine, Maebashi, Gunma, 371-8511, Japan; Nakano, T., National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba, 263-8555, Japan; Ohno, T., Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, 371-8511, Japan; Shibata, A., Signal Transduction Program, Gunma University Initiative for Advanced Research, Gunma University, Maebashi, Gunma, 371-8511, Japan |
Radiotherapy induces an immune response in the cancer microenvironment that may influence clinical outcome. The present study aimed to analyse the alteration of CD8+ T-cell infiltration and programmed death-ligand 1 (PD-L1) expression following radiotherapy in clinical samples from patients with uterine cervical squamous cell carcinoma. Additionally, the current study sought to analyse the associa- tion between these immune responses and clinical outcomes. A total of 75 patients who received either definitive chemoradio- therapy or radiotherapy were retrospectively analyzed. CD8+ T-cell infiltration and PD-L1 expression were determined by immunohistochemistry using biopsy specimens before radio- therapy (pre-RT) and after 10 Gy radiotherapy (post-10 Gy). The PD-L1+ rate was significantly increased from 5% (4/75) pre-RT to 52% (39/75) post-10 Gy (P<0.01). Despite this increase in the PD-L1+ rate post-10 Gy, there was no significant association between both pre-RT and post-10 Gy and overall survival (OS), locoregional control (LC) and progression-free survival (PFS). On the other hand, the CD8+ T-cell infiltration density was significantly decreased for all patients (median, 23.1% pre-RT vs. 16.9% post-10 Gy; P=0.038); however, this tended to increase in patients treated with radiotherapy alone (median, 17.7% pre-RT vs. 24.0% post-10 Gy; P=0.400). Notably, patients with high CD8+ T-cell infiltration either pre-RT or post-10 Gy exhibited positive associations with OS, LC and PFS. Thus, the present analysis suggested that CD8+ T-cell infiltration may be a prognostic biomarker for patients with cervical cancer receiving radiotherapy. Furthermore, immune checkpoint inhibitors may be effective in patients who have received radiotherapy, since radiotherapy upregu- lated PD-L1 expression in cervical cancer specimens. © 2021 Spandidos Publications. All rights reserved. |
CD8+ T cell; Cervical cancer; Immune modulation; Programmed death-ligand 1; Radiotherapy; Tumor microenvironment |
alcohol; biological marker; biotin; cisplatin; citric acid; diaminobenzidine; edetic acid; formaldehyde; hydrogen peroxide; immune checkpoint inhibitor; paraffin; peroxidase; platinum; programmed death 1 ligand 1; streptavidin; adult; aged; antigen retrieval; Article; biopsy; brachytherapy; cancer radiotherapy; cancer staging; CD8+ T lymphocyte; cell density; cell infiltration; chemoradiotherapy; controlled study; diagnostic test accuracy study; down regulation; female; follow up; human; human tissue; immune response; immunohistochemistry; irradiation; lymph node metastasis; major clinical study; microscopy; overall survival; paraffin embedding; progression free survival; protein expression; receiver operating characteristic; retrospective study; room temperature; tumor associated leukocyt |
Spandidos Publications |
17921074 |
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Article |
Q3 |
766 |
6367 |
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383 |
Pranata R., Henrina J., Yonas E., Putra I.C.S., Cahyadi I., Lim M.A., Munawar D.A., Munawar M. |
57201973901;57218482646;57201987097;57222144236;57221688594;57216039756;56470745000;16747447600; |
BMI and atrial fibrillation recurrence post catheter ablation: A dose-response meta-analysis |
2021 |
European Journal of Clinical Investigation |
51 |
6 |
e13499 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101961208&doi=10.1111%2feci.13499&partnerID=40&md5=72dba8a2a9279126fd9e453324e6df70 |
Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Binawaluya Cardiac Center, Jakarta, Indonesia; Balaraja General Hospital, Tangerang, Indonesia; Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Syamsudin SH General Hospital, Sukabumi, Indonesia; Pasar Rebo General Hospital, Jakarta, Indonesia; Department of Cardiology, Lyell McEwin Hospital, University of Adelaide, Elizabeth Vale, Australia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Binawaluya Cardiac Center, Jakarta, Indonesia; Henrina, J., Balaraja General Hospital, Tangerang, Indonesia; Yonas, E., Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Putra, I.C.S., Syamsudin SH General Hospital, Sukabumi, Indonesia; Cahyadi, I., Pasar Rebo General Hospital, Jakarta, Indonesia; Lim, M.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Munawar, D.A., Department of Cardiology, Lyell McEwin Hospital, University of Adelaide, Elizabeth Vale, Australia, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Munawar, M., Binawaluya Cardiac Center, Jakarta, Indonesia, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Introduction: The evidence on the association between obesity and atrial fibrillation (AF) recurrence was equivocal. We aimed to evaluate the dose-response relationship between body mass index (BMI) and AF recurrence and adverse events. Methods: A systematic literature search was conducted using PubMed, Europe PMC, EBSCO, ProQuest and Cochrane Library. Obesity was defined as BMI ≥28 kg/m2. The primary outcome was AF recurrence, and the secondary outcome was adverse events. Adverse events were defined as procedure-related complications and cardio-cerebrovascular events. Results: There were a total of 52,771 patients from 20 studies. Obesity was associated with higher AF recurrence (Odds ratio [OR] 1.30 [95% confidence interval [CI] 1.16-1.47], P <.001; I2: 72.7%) and similar rate of adverse events (OR 1.21 [95% CI 0.87-1.67], P =.264; I2: 23.9%). Meta-regression showed that the association varies by age (coefficient: −0.03, P =.024). Meta-analysis of highest versus lowest BMI showed that the highest group had higher AF recurrence (OR 1.37 [95% CI 1.18-1.58], P <.001; I2: 64.9%) and adverse events (OR 2.02 [95% CI 1.08-3.76], P =.028; I2: 49.5%). The linear association analysis for AF recurrence was not significant (P =.544). The dose-response relationship for BMI and AF recurrence was nonlinear (pnonlinearity < 0.001), the curve became steeper at 30-35 kg/m2. For adverse events, an increase of 1% for every 1 kg/m2 increase in BMI (OR 1.01 [95% CI 1.00-1.02], P =.001), the relationship was nonlinear (pnonlinearity = 0.001). Conclusion: Obesity was associated with higher AF recurrence in patients undergoing catheter ablation. High BMI might be associated with a higher risk for adverse events. PROSPERO ID: CRD42020198787. © 2021 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd |
arrhythmia; Atrial Fibrillation; catheter ablation; obesity; pulmonary vein isolation |
anticoagulant agent; warfarin; adult; adverse event; age; aged; Article; atrial fibrillation; body mass; cardiovascular disease; catheter ablation; cerebrovascular disease; female; high risk patient; human; male; meta analysis; middle aged; obesity; outcome assessment; recurrence risk; systematic review; atrial fibrillation; body mass; obesity; recurrent disease; severity of illness index; Atrial Fibrillation; Body Mass Index; Catheter Ablation; Humans; Obesity; Overweight; Recurrence; Severity of Illness Index |
John Wiley and Sons Inc |
00142972 |
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33544873 |
Article |
Q1 |
1164 |
3461 |
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384 |
Octaviana F., Yugo H.P., Safri A.Y., Indrawati L.A., Wiratman W., Ayuningtyas T., Hakim M. |
26029958700;57222124227;57091699300;57205117182;57191920526;57222133312;57216861859; |
Case series: COVID-19 in patients with mild to moderate myasthenia gravis in a National Referral Hospital in Indonesia |
2021 |
eNeurologicalSci |
23 |
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100332 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101576141&doi=10.1016%2fj.ensci.2021.100332&partnerID=40&md5=ccc7fd67857e6642deba6a14cfa9ae62 |
Neurology Department, Faculty of Medicine, Universitas Indonesia, Indonesia; Cipto Mangunkusomo National General Hospital, Jakarta, Indonesia |
Octaviana, F., Neurology Department, Faculty of Medicine, Universitas Indonesia, Indonesia, Cipto Mangunkusomo National General Hospital, Jakarta, Indonesia; Yugo, H.P., Neurology Department, Faculty of Medicine, Universitas Indonesia, Indonesia, Cipto Mangunkusomo National General Hospital, Jakarta, Indonesia; Safri, A.Y., Neurology Department, Faculty of Medicine, Universitas Indonesia, Indonesia, Cipto Mangunkusomo National General Hospital, Jakarta, Indonesia; Indrawati, L.A., Neurology Department, Faculty of Medicine, Universitas Indonesia, Indonesia, Cipto Mangunkusomo National General Hospital, Jakarta, Indonesia; Wiratman, W., Neurology Department, Faculty of Medicine, Universitas Indonesia, Indonesia, Cipto Mangunkusomo National General Hospital, Jakarta, Indonesia; Ayuningtyas, T., Neurology Department, Faculty of Medicine, Universitas Indonesia, Indonesia, Cipto Mangunkusomo National General Hospital, Jakarta, Indonesia; Hakim, M., Neurology Department, Faculty of Medicine, Universitas Indonesia, Indonesia, Cipto Mangunkusomo National General Hospital, Jakarta, Indonesia |
Background: During the COVID-19 pandemic, patients with myasthenia gravis (MG) are most likely to be affected by this situation. Corticosteroids and immunosuppressant agents increase the risk of severe infection. Furthermore, viral infection and some medications in COVID-19 may exacerbate MG symptoms. Case description: We presented three patients with MG who contracted COVID-19. All of the patients had a favourable outcome. Only one patient who was not treated with corticosteroids or immunosuppressant therapy experienced deterioration of MG symptoms, while the other patients who received immunosuppressant therapy did not develop MG exacerbation. Surprisingly, azithromycin did not provoke myasthenic crisis (MC) in patients with normal MGFA classification. Conclusion: Using immunosuppressant agents may not lead to MG deterioration and may not be related to unfavourable outcomes. © 2021 The Author(s) |
COVID-19; Immunosuppressant; Myasthenia gravis |
acetylcysteine; alanine aminotransferase; ascorbic acid; aspartate aminotransferase; azathioprine; azithromycin; C reactive protein; ceftriaxone; D dimer; hydroxychloroquine; methylprednisolone; mycophenolate mofetil; oxygen; paracetamol; procalcitonin; pyridostigmine; abduction; adult; anosmia; Article; blood analysis; body temperature; case report; clinical article; clinical classification; consultation; coronavirus disease 2019; coughing; deterioration; diarrhea; disease exacerbation; drug dose increase; dry cough; dysphagia; fatigue; female; fever; food intake; home quarantine; hospital admission; hospital discharge; hospitalization; human; human tissue; Indonesia; leukocytosis; lung auscultation; lung infiltrate; male; mastication; medical history; middle aged; mucus; muscle weakness; |
Elsevier B.V. |
24056502 |
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570 |
8868 |
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391 |
Wente-Schulz S., Aksenova M., Awan A., Ambarsari C.G., Becherucci F., Emma F., Fila M., Francisco T., Gokce I., Gülhan B., Hansen M., Jahnukainen T., Kallash M., Kamperis K., Mason S., Mastrangelo A., Mencarelli F., Niwinska-Faryna B., Riordan M., Rus R.R., Saygili S., Serdaroglu E., Taner S., Topaloglu R., Vidal E., Woroniecki R., Yel S., Zieg J., Pape L., Boyer O., Buder K., Bulut Ä°.K., Cornelissen E.A.M., del Mar Espino Hernández M., Hooman N., Kemper M., Maquet J., Santos F., Walden U., The international TIN study group |
57219293227;56461027300;7005794049;57211850895;23391748500;6701866332;47760976500;55642167100;16238883200;16244621000;57026872000;6602193869;55189985500;6507713677;56025783100;16245571200;23989069700;24402868000;36828392800;56126830800;36926397400;55910586900;57204046122;7005610220;57200885825;8351699100;43861951500;37762449000;7007073757;8509255100;57423156500;42360924700;7003896668;56868570600;22634317400;55946766900;57199406014;7202141204;57189522337; |
Aetiology, course and treatment of acute tubulointerstitial nephritis in paediatric patients: A cross-sectional web-based survey |
2021 |
BMJ Open |
11 |
5 |
e047059 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107244372&doi=10.1136%2fbmjopen-2020-047059&partnerID=40&md5=8b9d8549b7d6c5d3a71a823dffc235d5 |
Department of Pediatric Nephrology, MHH, Hannover, Germany; Department of Pediatric Nephrology, Veltischev Research and Clinical Institute for Pediatrics, The Pirogov Russian National Research Medical University, Moskva, Russian Federation; Department of Pediatric Nephrology, Temple Street Children's University Hospital, Dublin, Ireland; Department of Pediatric Nephrology, Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia, Central Jakarta, Indonesia; Department of Pediatric Nephrology, Meyer Children's Hospital, Florence, Italy; Department of Pediatric Nephrology, Bambino Gesù Children's Hospital, Roma, Italy; Department of Pediatric Nephrology, Montpellier University, Arnaud de Villeneuve Hospital, Montpellier, France; Department of Pediatric Nephrology, Dona Estefânia Hospital, Lisboa, Portugal; Department of Pediatric Nephrology, Faculty of Medicine, Marmara University, Istanbul, Turkey; Department of Pediatric Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Turkey; KfH Centre of Pediatric Nephrology, Clementine Kinderhospital, Frankfurt am Main, Germany; Department of Pediatric Nephrology and Transplantation, New Children's Hospital, Helsinki University Hospital, Helsinki, Finland; Department of Pediatric Nephrology, Nationwide Children's Hospital, Columbus, OH, United States; Department of Pediatric Nephrology, Aarhus University Hospital, Aarhus, Denmark; Department of Pediatric Nephrology, Connecticut Children's Medical Center, Hartford, CT, United States; Department of Pediatric Nephrology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pediatric Nephrology, Azienda Ospedaliero-Universitaria di Bologna, Ospedale S. Orsola-Malpighi, Bologna, Italy; Department of Pediatric Nephrology, Karolinska University Hospital, Stockholm, Sweden; Department of Pediatric Nephrology, University Children's Hospital, Ljubljana, Slovenia; Department of Pediatric Nephrology, Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey; Department of Pediatric Nephrology, Dr Behcet Uz Children Hospital, Izmir, Turkey; Department of Pediatric Nephrology, Faculty of Medicine, Ege University, Izmir, Turkey; Department of Pediatric Nephrology, University Hospital of Padova, Padova, Italy; Department of Pediatric Nephrology, Stony Brook Children's Hospital, Stony Brook, NY, United States; Department of Pediatric Nephrology, Faculty of Medicine, Erciyes University, Kayseri, Turkey; Department of Pediatric Nephrology, 2nf Faculty of Medicine, University Hospital Motol, Charles University, Praha, Czech Republic; Department of Pediatrics II, University Hospital Essen, Essen, Germany; Hôpital Necker-Enfants malades, MARHEA, Institut Imagine, Université de Paris, Paris, France; Pediatric Department, University Hospital Carl Gustav Carus, Technical University, Dresden, Germany; Ege University Faculty of Medicine, Izmir, Turkey; Radboud University Medical Center, Nijmegen, Netherlands; Hospital Universitario 12 de Octubre, Madrid, Spain; Ali-Asghar Clinical Research Development Center, Iran University of Medical Sciences, Tehran, Iran; Asklepios Medical School, Hamburg, Germany; CHC Liège, Belgium; Pediatric Nephrology, Hospital Universitario Central de Asturias, University of Oviedo, Spain; Universitätsklinikum Kinderklinik Augsburg, Germany |
Wente-Schulz, S., Department of Pediatric Nephrology, MHH, Hannover, Germany; Aksenova, M., Department of Pediatric Nephrology, Veltischev Research and Clinical Institute for Pediatrics, The Pirogov Russian National Research Medical University, Moskva, Russian Federation; Awan, A., Department of Pediatric Nephrology, Temple Street Children's University Hospital, Dublin, Ireland; Ambarsari, C.G., Department of Pediatric Nephrology, Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia, Central Jakarta, Indonesia; Becherucci, F., Department of Pediatric Nephrology, Meyer Children's Hospital, Florence, Italy; Emma, F., Department of Pediatric Nephrology, Bambino Gesù Children's Hospital, Roma, Italy; Fila, M., Department of Pediatric Nephrology, Montpellier University, Arnaud de Villeneuve Hospital, Montpellier, France; Francisco, T., Department of Pediatric Nephrology, Dona Estefânia Hospital, Lisboa, Portugal; Gokce, I., Department of Pediatric Nephrology, Faculty of Medicine, Marmara University, Istanbul, Turkey; Gülhan, B., Department of Pediatric Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Turkey; Hansen, M., KfH Centre of Pediatric Nephrology, Clementine Kinderhospital, Frankfurt am Main, Germany; Jahnukainen, T., Department of Pediatric Nephrology and Transplantation, New Children's Hospital, Helsinki University Hospital, Helsinki, Finland; Kallash, M., Department of Pediatric Nephrology, Nationwide Children's Hospital, Columbus, OH, United States; Kamperis, K., Department of Pediatric Nephrology, Aarhus University Hospital, Aarhus, Denmark; Mason, S., Department of Pediatric Nephrology, Connecticut Children's Medical Center, Hartford, CT, United States; Mastrangelo, A., Department of Pediatric Nephrology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Mencarelli, F., Department of Pediatric Nephrology, Azienda Ospedaliero-Universitaria di Bologna, Ospedale S. Orsola-Malpighi, Bologna, Italy; Niwinska-Faryna, B., Department of Pediatric Nephrology, Karolinska University Hospital, Stockholm, Sweden; Riordan, M., Department of Pediatric Nephrology, Temple Street Children's University Hospital, Dublin, Ireland; Rus, R.R., Department of Pediatric Nephrology, University Children's Hospital, Ljubljana, Slovenia; Saygili, S., Department of Pediatric Nephrology, Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey; Serdaroglu, E., Department of Pediatric Nephrology, Dr Behcet Uz Children Hospital, Izmir, Turkey; Taner, S., Department of Pediatric Nephrology, Faculty of Medicine, Ege University, Izmir, Turkey; Topaloglu, R., Department of Pediatric Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Turkey; Vidal, E., Department of Pediatric Nephrology, University Hospital of Padova, Padova, Italy; Woroniecki, R., Department of Pediatric Nephrology, Stony Brook Children's Hospital, Stony Brook, NY, United States; Yel, S., Department of Pediatric Nephrology, Faculty of Medicine, Erciyes University, Kayseri, Turkey; Zieg, J., Department of Pediatric Nephrology, 2nf Faculty of Medicine, University Hospital Motol, Charles University, Praha, Czech Republic; Pape, L., Department of Pediatrics II, University Hospital Essen, Essen, Germany; Boyer, O., Hôpital Necker-Enfants malades, MARHEA, Institut Imagine, Université de Paris, Paris, France; Buder, K., Pediatric Department, University Hospital Carl Gustav Carus, Technical University, Dresden, Germany; Bulut, Ä°.K., Ege University Faculty of Medicine, Izmir, Turkey; Cornelissen, E.A.M., Radboud University Medical Center, Nijmegen, Netherlands; del Mar Espino Hernández, M., Hospital Universitario 12 de Octubre, Madrid, Spain; Hooman, N., Ali-Asghar Clinical Research Development Center, Iran University of Medical Sciences, Tehran, Iran; Kemper, M., Asklepios Medical School, Hamburg, Germany; Maquet, J., CHC Liège, Belgium; Santos, F., Pediatric Nephrology, Hospital Universitario Central de Asturias, University of Oviedo, Spain; Walden, U., Universitätsklinikum Kinderklinik Augsburg, Germany; The international TIN study group |
Background Acute tubulointerstitial nephritis (TIN) is a significant cause of acute renal failure in paediatric and adult patients. There are no large paediatric series focusing on the aetiology, treatment and courses of acute TIN. Patients, design and setting We collected retrospective clinical data from paediatric patients with acute biopsy-proven TIN by means of an online survey. Members of four professional societies were invited to participate. Results Thirty-nine physicians from 18 countries responded. 171 patients with acute TIN were included (54% female, median age 12 years). The most frequent causes were tubulointerstitial nephritis and uveitis syndrome in 31% and drug-induced TIN in 30% (the majority of these caused by non-steroidal anti-inflammatory drugs). In 28% of patients, no initiating noxae were identified (idiopathic TIN). Median estimated glomerular filtration rate (eGFR) rose significantly from 31 at time of renal biopsy to 86 mL/ min/1.73 m2 3-6 months later (p<0.001). After 3-6 months, eGFR normalised in 41% of patients (eGFR ≥90 mL/ min/1.73 m2), with only 3% having severe or end-stage impairment of renal function (<30 mL/min/1.73 m2). 80% of patients received corticosteroid therapy. Median eGFR after 3-6 months did not differ between steroid-treated and steroid-untreated patients. Other immunosuppressants were used in 18% (n=31) of patients, 21 of whom received mycophenolate mofetil. Conclusions Despite different aetiologies, acute paediatric TIN had a favourable outcome overall with 88% of patients showing no or mild impairment of eGFR after 3-6 months. Prospective randomised controlled trials are needed to evaluate the efficacy of glucocorticoid treatment in paediatric patients with acute TIN. © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
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aciclovir; amoxicillin plus clavulanic acid; antiinfective agent; bee venom; chlorpheniramine maleate; corticosteroid; cotrimoxazole; flurbiprofen; herbaceous agent; hydrochlorothiazide; ibuprofen; immunosuppressive agent; ketoprofen; levetiracetam; mesalazine; methylprednisolone; midecamycin; morniflumate; mycophenolate mofetil; nonsteroid antiinflammatory agent; oxcarbazepine; paracetamol; penicillin G potassium; prednisolone; prednisone; toxic substance; anuria; arthralgia; Article; child; clinical feature; cohort analysis; controlled study; corticosteroid therapy; cross-sectional study; disease course; end stage renal disease; enuresis; estimated glomerular filtration rate; eye disease; fatigue; female; fever; flank pain; glucosuria; headache; health care survey; hematuria; human; huma |
BMJ Publishing Group |
20446055 |
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34049919 |
Article |
Q1 |
1132 |
3624 |
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392 |
Hardiany N.S., Amaanullah M.Z.B., Antarianto R.D. |
57192910605;57224223597;57190862806; |
The effect of fasting on malondialdehyde level in liver and plasma of New Zealand white rabbits |
2021 |
AIP Conference Proceedings |
2353 |
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030093 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107282294&doi=10.1063%2f5.0052627&partnerID=40&md5=f1091bc64391ab80b12474af251808e8 |
Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Indonesia; Center of Hypoxia and Oxidative Stress Studies, Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia, Indonesia; Faculty of Medicine Universitas Indonesia, Indonesia; Departemnet of Histology, Faculty of Medicine Universitas Indonesia, Indonesia |
Hardiany, N.S., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Indonesia, Center of Hypoxia and Oxidative Stress Studies, Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia, Indonesia; Amaanullah, M.Z.B., Faculty of Medicine Universitas Indonesia, Indonesia; Antarianto, R.D., Departemnet of Histology, Faculty of Medicine Universitas Indonesia, Indonesia |
Oxidative stress is a state of imbalance of free radicals in the cells and is one of the causes of various diseases in humans. One method that is thought to reduce oxidative stress is calorie restriction or fasting. However, its effects remain unclear. This study was conducted to determine the effect of intermittent fasting and prolonged fasting on the levels of malondialdehyde (MDA) as an oxidative stress marker in the liver and plasma of New Zealand White rabbits. Fifteen of New Zealand White rabbits were divided into three groups (intermittent fasting (IF), prolonged fasting (PF), and control). MDA was measured in plasma and liver homogenate using spectrophotometry. The results were analyzed using One-way ANOVA test. The liver MDA level was decreased in the IF group, but not significant. However, there was a significant increase in plasma MDA levels both in the IF and PF groups. Moreover, liver MDA level was increased in PF group, although it was not significant. In conclusion, intermittent and prolonged fasting could increase plasma MDA levels significantly. © 2021 Author(s). |
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American Institute of Physics Inc. |
0094243X |
9780735440968 |
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Conference Paper |
- |
177 |
20880 |
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393 |
Yusra Y., Widjaja L., Witjaksono F., Timan I.S., Kumalawati J., Adiyanti S.S., Nurbaya S., Immanuel S. |
57220998367;56906852200;57070455800;6602793366;6504406695;57191952811;57225297244;12777341300; |
Amino acid profile in patients of chronic kidney disease on hemodialysis in Indonesia |
2021 |
AIP Conference Proceedings |
2353 |
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030014 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107266850&doi=10.1063%2f5.0052847&partnerID=40&md5=ca448315d7144ead78ebf8040fae2eb4 |
Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia |
Yusra, Y., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Widjaja, L., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Witjaksono, F., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Timan, I.S., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Kumalawati, J., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Adiyanti, S.S., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Nurbaya, S., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Immanuel, S., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia |
Protein energy wasting (PEW) is a nutritional disorder syndrome that occurs 28-80% in chronic kidney disease (CKD) patients on hemodialysis. Hemodialysis cause the nutrients loss including amino acids, increase protein catabolism induced by inflammation, and inhibit protein synthesis. The objective of this study was to acquire the amino acid profile in CKD patients on hemodialysis. This study used cross sectional design and involving 60 subjects of CKD patients aged >18 years on routine hemodialysis at Dr. Cipto Mangunkusumo National Referral Hospital. Amino acids examination was using dried blood spots (DBSs) sample and Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) method. We examined 10 non-essential (alanine, arginine, aspartic acid, glutamic acid, asparagine, glycine, glutamine, proline, serine, tyrosine), 9 essentials (histidine, phenylalanine, isoleucine, leucine, lysine, methionine, threonine, tryptophan, valine), and 2 special (ornithine, citrulline) amino acids. The results showed that almost all amino acids were lower (6 non-essential, 8 essentials, and citrulline), whereas others were higher (aspartate acid, serine) or normal (glutamic acid, glycine, methionine, and ornithine) than normal reference value from Mayo. CKD patients on hemodialysis have decreased amino acid especially essential amino acids. These results can be used in modification of amino acid supplementation CKD patient on hemodialysis in Indonesia. © 2021 Author(s). |
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American Institute of Physics Inc. |
0094243X |
9780735440968 |
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Conference Paper |
- |
177 |
20880 |
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394 |
Abdullah M., Sudrajat D.G., Muzellina V.N., Kurniawan J., Rizka A., Utari A.P., Pribadi R.R., Idrus M.F., Yusra Y., Meilany S., Surandy A., Shatri H., Rinaldi I., Pitoyo C.W., Renaldi K. |
7103393434;54893136100;57223968527;57193251655;57203243658;57113585900;57194732282;57223976376;57220998367;57193709281;57223964417;28767986500;23475122400;26022606900;57190963547; |
The value of anal swab RT-PCR for COVID-19 diagnosis in adult Indonesian patients |
2021 |
BMJ Open Gastroenterology |
8 |
1 |
e000590 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106611204&doi=10.1136%2fbmjgast-2020-000590&partnerID=40&md5=cc17ce689ac73f1e46021151c9319871 |
Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Indonesia Medical Education and Research Institute - Human Cancer Research Center, University of Indonesia Faculty of Medicine, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Hepatobilliary Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Geriatric Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Department of Clinical Pathology, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region Jakarta, Indonesia; Research Center for Virology and Cancer Pathobiology, University of Indonesia Faculty of Medicine, Jakarta, Special Capital Region of Jakarta, Indonesia; Psychosomatic and Palliative Care Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Special Capital Region of Jakarta, Central Jakarta, Indonesia; Hematology and Medical Oncology Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Respirology and Critical Care Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia |
Abdullah, M., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia, Indonesia Medical Education and Research Institute - Human Cancer Research Center, University of Indonesia Faculty of Medicine, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Sudrajat, D.G., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Muzellina, V.N., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Kurniawan, J., Hepatobilliary Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Rizka, A., Geriatric Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Utari, A.P., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Pribadi, R.R., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Idrus, M.F., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Yusra, Y., Department of Clinical Pathology, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region Jakarta, Indonesia; Meilany, S., Research Center for Virology and Cancer Pathobiology, University of Indonesia Faculty of Medicine, Jakarta, Special Capital Region of Jakarta, Indonesia; Surandy, A., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Shatri, H., Psychosomatic and Palliative Care Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Special Capital Region of Jakarta, Central Jakarta, Indonesia; Rinaldi, I., Hematology and Medical Oncology Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Pitoyo, C.W., Respirology and Critical Care Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Renaldi, K., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia |
Objective This study will test the performance of the anal swab PCR test when compared with the nasopharyngeal swab PCR test as a diagnostic tool for COVID-19. Design An observational descriptive study which included hospitalised suspected, or probable cases of hopitalised COVID-19 patients, conducted in Dr. Cipto Mangunkusumo National Hospital, Ciputra Hospital, Mitra Keluarga Depok Hospital and Mitra Keluarga Kelapa Gading Hospital, Indonesia. Epidemiological, clinical, laboratory and radiology data were obtained. Nasopharyngeal and anal swabs specimens were collected for SARS-CoV-2 RNA detection. Results We analysed 136 subjects as part of this study. The clinical spectrum of COVID-19 manifesation in this study was typical of hospitalised patients, with 25% classified as mild cases, 14.7% in severe condition and 12.5% of subjects classified as having acute respiratory distress syndrome. When compared with nasopharyngeal swab as the standard specimen for reverse transcription polymerase chain reaction (RT-PCR) detection of SARS-CoV-2 antigen, the sensitivity and specificity of the anal swab was 36.7% and 93.8%, respectively. The positive and negative predictive value were 97.8% and 16.5 %, respectively. The performance of the anal swab remained similar when only the subgroup of patients with gastrointestinal symptoms (n=92, 67.6%) was analysed (sensitivity 40% and specificity 91.7%). Out of all the subjects included in analysis, 67.6% had gastrointestinal symptoms. Similarly, 73.3% of patients in the anal swab-positive group had gastrointestinal symptoms. The two most common gastrointestinal symptoms in the subjects' population were nausea and anorexia. Conclusion Anal swab specimen has low sensitivity (36.7%) but high specificity (93.8%) for detecting SARS-CoV-2 antigen by RT-PCR. Only one additional positive result was found by anal swab among the nasopharyngeal swab-negative group. Anal swab may not be needed as an additional test at the beginning of a patient's diagnostic investigation and nasopharyngeal swab RT-PCR remains as the standard diagnostic test for COVID-19. © 2020 American Society of Mechanical Engineers (ASME). All rights reserved. |
anal; COVID-19; diagnostic virology |
abdominal pain; adult; adult respiratory distress syndrome; anal swab; anorexia; Article; body mass; clinical laboratory; controlled study; coronavirus disease 2019; coughing; COVID-19 testing; current smoker; diagnostic test accuracy study; diarrhea; ex-smoker; female; fever; gastrointestinal symptom; headache; heart disease; hospital patient; human; hypertension; Indonesian; lung disease; major clinical study; malaise; male; mortality rate; nasopharyngeal swab; nausea; non insulin dependent diabetes mellitus; practice guideline; predictive value; priority journal; respiratory tract infection; reverse transcription polymerase chain reaction; sensitivity and specificity; sore throat |
BMJ Publishing Group |
20544774 |
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Article |
Q1 |
1240 |
3126 |
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397 |
Siste K., Hanafi E., Sen L.T., Murtani B.J., Christian H., Limawan A.P., Siswidiani L.P., Adrian |
55644113100;56737010600;57219034101;57216652176;57209266195;57202712511;57219029296;57216932703; |
Implications of COVID-19 and Lockdown on Internet Addiction Among Adolescents: Data From a Developing Country |
2021 |
Frontiers in Psychiatry |
12 |
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665675 |
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6 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107077623&doi=10.3389%2ffpsyt.2021.665675&partnerID=40&md5=19567c64b9f1c1b25ae702d165f6737d |
Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Siste, K., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Hanafi, E., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Sen, L.T., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Murtani, B.J., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Christian, H., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Limawan, A.P., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Siswidiani, L.P., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Adrian, Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Introduction: Physical distancing policy during coronavirus disease 2019 (COVID-19) pandemic requires adolescents to spend most of their time at home, thus increasing Internet use duration. Limited social interaction with their peers may lead to loneliness and an increased risk of mental health among adolescents. This study aimed to assess the prevalence of Internet addiction (IA) among adolescents and analyze the influence of psychosocial factors toward the heightened risk of IA during the COVID-19 pandemic. Methods: An online survey comprising sociodemographic questionnaire, Internet Addiction Diagnostic Questionnaire (KDAI), Strengths and Difficulties Questionnaire (SDQ), and Pittsburgh Sleep Quality Index (PSQI) was distributed. Overall, a total of 2,932 adolescents (mean age, 17.38 ± 2.24 years old; female, 78.7%), originating from 33 of 34 provinces in Indonesia, completed the survey. Results: The point prevalence of IA among Indonesian adolescents during the COVID-19 outbreak was 19.3%. Increased Internet use duration, internalization, externalization, low prosocial behavior, and sleep disturbances were found as risk factors of IA, either directly or as mediating variables. Physical distancing, large-scale social restriction (PSBB), and health status were not correlated to IA. Discussion: Physical distancing was not established as a risk of IA. This could be due to other psychological factors such as internalization, externalization, prosocial, and sleep problems that had correlations to IA occurrence among adolescents in the COVID-19 pandemic. Sleep impairment might have resulted from the emotional and behavioral issues and directly contributed to IA development. Conclusion: The present study found the prevalence of IA among Indonesian adolescents to be higher than the adult during the COVID-19 pandemic. Several psychological measures were indicated to increase the risk of IA, while physical distancing did not elevate the risk. Thus, remote schooling is preferable in Indonesia along with proper parental supervision to minimize Internet use for entertainment purposes. © Copyright © 2021 Siste, Hanafi, Sen, Murtani, Christian, Limawan, Siswidiani and Adrian. |
adolescents; coronavirus disease 2019; Indonesia; internet addiction; lockdown; physical distancing; psychopathology; sleep quality |
adolescent; adolescent disease; age distribution; Article; behavior disorder; controlled study; coronavirus disease 2019; demography; developing country; emotional disorder; externalization (behavior); female; health status; health survey; human; Indonesia; Indonesian; internalization (behavior); internet addiction; Internet Addiction Diagnostic Questionnaire; major clinical study; male; national lockdown; pandemic; Pittsburgh Sleep Quality Index; prevalence; prosocial behavior; psychological aspect; questionnaire; risk assessment; sex ratio; sleep disorder; social aspect; social distancing; social psychology; strengths and difficulties questionnaire |
Frontiers Media S.A. |
16640640 |
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Article |
Q1 |
1363 |
2668 |
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400 |
Han W.M., Jiamsakul A., Salleh N.A.M., Choi J.Y., Huy B.V., Yunihastuti E., Do C.D., Merati T.P., Gani Y.M., Kiertiburanakul S., Zhang F., Chan Y.-J., Lee M.-P., Chaiwarith R., Ng O.T., Khusuwan S., Ditangco R., Kumarasamy N., Sangle S., Ross J., Avihingsanon A., Ly P.S., Khol V., Zhang F.J., Zhao H.X., Han N., Lee M.P., Li P.C.K., Lam W., Chan Y.T., Kumarasamy N., Ezhilarasi C., Pujari S., Joshi K., Gaikwad S., Chitalikar A., Sangle S., Mave V., Marbaniang I., Nimkar S., Merati T.P., Wirawan D.N., Yuliana F., Yunihastuti E., Widhani A., Maria S., Karjadi T.H., Tanuma J., Oka S., Nishijima T., Choi J.Y., Na S., Kim J.M., Gani Y.M., Rudi N.B., Azwa I., Kamarulzaman A., Syed Omar S.F., Ponnampalavanar S., Ditangco R., Pasayan M.K., Mationg M.L., Chan Y.J., Ku W.W., Wu P.C., Ke E., Ng O.T., Lim P.L., Lee L.S., Liang D., Avihingsanon A., Gatechompol S., Phanuphak P., Phadungphon C., Phuphuakrat A., Chumla L., Sanmeema N., Chaiwarith R., Sirisanthana T., Praparattanapan J., Nuket K., Khusuwan S., Kantipong P., Kambua P., Nguyen K.V., Bui H.V., Nguyen D.T.H., Nguyen D.T., Do C.D., Ngo A.V., Nguyen L.T., Sohn A.H., Ross J.L., Petersen B., Law M.G., Jiamsakul A., Bijker R., Rupasinghe D., TREAT Asia HIV Observational Database (TAHOD) of the International Epidemiology Databases to Evaluate AIDS (IeDEA) Asia-Pacific Group |
57201984684;55285745500;57209499322;48761023600;55757403300;57221273925;55035577700;8935806500;57188842533;6506539792;23007277900;57258255400;57309539000;13806165200;57215769524;56166613100;55406840800;7003549856;6602877716;57193109926;57196347321;57204852770;57188842644;55503803800;35796801900;57206253688;56143671100;57203375227;57188836039;57188839065;55412491000;55413091200;57205894660;35227451500;55273903300;57188839029;57257928100;24778446900;57189801547;56820043000;57203678680;6601921496;57202976978;8850357600;57202561455;57213345044;57219422563;57208428839;57202558648;57226409961;57294788000;14037572300;7601387767;57188842533;57257789600;55553159100;6603019663;55295731300;36768852500;57258598000;57207954173;36936083900;33667461800;55856943500;56514424400;57257813200;57203665233;10041498300;55992506400;57258040600;57200282477;57193906863;7004982661;56015716600;8277552900;56515326900;55992497800;57203665049;7004277229;35185428900;57192871045;56166613100;6603580797;55285745100;56370854300;56498653200;56970337500;57190300831;56658396600;57208054163;41961438300;7006405275;57217343074;56406054800;55556254800;55285745500;57188697907;57205313395; |
HIV treatment outcomes among people who acquired HIV via injecting drug use in the Asia-Pacific region: a longitudinal cohort study |
2021 |
Journal of the International AIDS Society |
24 |
5 |
e25736 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106697623&doi=10.1002%2fjia2.25736&partnerID=40&md5=5b62ec1b7839280e4b8e69702122c64a |
Kirby Institute, UNSW, Sydney, Australia; HIV-NAT, Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Centre of Excellence for Research in AIDS (CERiA), University of Malaya, Kuala Lumpur, Malaysia; Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; National Hospital for Tropical Diseases, Hanoi, Viet Nam; Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Bach Mai Hospital, Hanoi, Viet Nam; Faculty of Medicine, Udayana University & Sanglah Hospital, Bali, Indonesia; Hospital Sungai Buloh, Sungai Buloh, Malaysia; Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Beijing Ditan Hospital, Capital Medical University, Beijing, China; Taipei Veterans General Hospital, Taipei, Taiwan; Queen Elizabeth Hospital, Hong Kong; Research Institute for Health Sciences, Chiang Mai, Thailand; Tan Tock Seng Hospital, Tan Tock Seng, Singapore; Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; Research Institute for Tropical Medicine, Muntinlupa City, Philippines; Chennai Antiviral Research and Treatment Clinical Research Site (CART CRS), VHS-Infectious Diseases Medical Centre, VHSChennai, India; BJ Government Medical College and Sassoon General Hospital, Pune, India; TREAT Asia, amfAR - The Foundation for AIDS Research, Bangkok, Thailand; Tuberculosis Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; National Center for HIV/AIDS, Dermatology & STDs, Phnom Penh, Cambodia; Beijing Ditan Hospital, Capital Medical University, Beijing, China; Queen Elizabeth Hospital, Hong Kong; Chennai Antiviral Research and Treatment Clinical Research Site (CART CRS), VHS-Infectious Diseases Medical Centre, VHS, Chennai, India; Institute of Infectious Diseases, Pune, India; BJ Government Medical College and Sassoon General Hospital, Pune, India; Faculty of Medicine Udayana University & Sanglah Hospital, Bali, Indonesia; Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; National Center for Global Health and Medicine, Tokyo, Japan; Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Hospital Sungai Buloh, Sungai Buloh, Malaysia; University Malaya Medical Centre, Kuala Lumpur, Malaysia; Research Institute for Tropical Medicine, Muntinlupa City, Philippines; Taipei Veterans General Hospital, Taipei, Taiwan; Tan Tock Seng Hospital, Singapore; HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Research Institute for Health Sciences, Chiang Mai, Thailand; Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; National Hospital for Tropical Diseases, Hanoi, Viet Nam; Bach Mai Hospital, Hanoi, Viet Nam; TREAT Asia, amfAR - The Foundation for AIDS Research, Bangkok, Thailand; The Kirby Institute, UNSW SydneyNSW, Australia |
Han, W.M., Kirby Institute, UNSW, Sydney, Australia, HIV-NAT, Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Jiamsakul, A., Kirby Institute, UNSW, Sydney, Australia, The Kirby Institute, UNSW SydneyNSW, Australia; Salleh, N.A.M., Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia, Centre of Excellence for Research in AIDS (CERiA), University of Malaya, Kuala Lumpur, Malaysia; Choi, J.Y., Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Huy, B.V., National Hospital for Tropical Diseases, Hanoi, Viet Nam; Yunihastuti, E., Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Do, C.D., Bach Mai Hospital, Hanoi, Viet Nam; Merati, T.P., Faculty of Medicine, Udayana University & Sanglah Hospital, Bali, Indonesia; Gani, Y.M., Hospital Sungai Buloh, Sungai Buloh, Malaysia, Hospital Sungai Buloh, Sungai Buloh, Malaysia; Kiertiburanakul, S., Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Zhang, F., Beijing Ditan Hospital, Capital Medical University, Beijing, China; Chan, Y.-J., Taipei Veterans General Hospital, Taipei, Taiwan; Lee, M.-P., Queen Elizabeth Hospital, Hong Kong; Chaiwarith, R., Research Institute for Health Sciences, Chiang Mai, Thailand; Ng, O.T., Tan Tock Seng Hospital, Tan Tock Seng, Singapore; Khusuwan, S., Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand, Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; Ditangco, R., Research Institute for Tropical Medicine, Muntinlupa City, Philippines; Kumarasamy, N., Chennai Antiviral Research and Treatment Clinical Research Site (CART CRS), VHS-Infectious Diseases Medical Centre, VHSChennai, India; Sangle, S., BJ Government Medical College and Sassoon General Hospital, Pune, India; Ross, J., TREAT Asia, amfAR - The Foundation for AIDS Research, Bangkok, Thailand; Avihingsanon, A., HIV-NAT, Thai Red Cross AIDS Research Centre, Bangkok, Thailand, Tuberculosis Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Ly, P.S., National Center for HIV/AIDS, Dermatology & STDs, Phnom Penh, Cambodia; Khol, V., National Center for HIV/AIDS, Dermatology & STDs, Phnom Penh, Cambodia; Zhang, F.J., Beijing Ditan Hospital, Capital Medical University, Beijing, China; Zhao, H.X., Beijing Ditan Hospital, Capital Medical University, Beijing, China; Han, N., Beijing Ditan Hospital, Capital Medical University, Beijing, China; Lee, M.P., Queen Elizabeth Hospital, Hong Kong; Li, P.C.K., Queen Elizabeth Hospital, Hong Kong; Lam, W., Queen Elizabeth Hospital, Hong Kong; Chan, Y.T., Queen Elizabeth Hospital, Hong Kong; Kumarasamy, N., Chennai Antiviral Research and Treatment Clinical Research Site (CART CRS), VHS-Infectious Diseases Medical Centre, VHS, Chennai, India; Ezhilarasi, C., Chennai Antiviral Research and Treatment Clinical Research Site (CART CRS), VHS-Infectious Diseases Medical Centre, VHS, Chennai, India; Pujari, S., Institute of Infectious Diseases, Pune, India; Joshi, K., Institute of Infectious Diseases, Pune, India; Gaikwad, S., Institute of Infectious Diseases, Pune, India; Chitalikar, A., Institute of Infectious Diseases, Pune, India; Sangle, S., BJ Government Medical College and Sassoon General Hospital, Pune, India; Mave, V., BJ Government Medical College and Sassoon General Hospital, Pune, India; Marbaniang, I., BJ Government Medical College and Sassoon General Hospital, Pune, India; Nimkar, S., BJ Government Medical College and Sassoon General Hospital, Pune, India; Merati, T.P., Faculty of Medicine Udayana University & Sanglah Hospital, Bali, Indonesia; Wirawan, D.N., Faculty of Medicine Udayana University & Sanglah Hospital, Bali, Indonesia; Yuliana, F., Faculty of Medicine Udayana University & Sanglah Hospital, Bali, Indonesia; Yunihastuti, E., Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Widhani, A., Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Maria, S., Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Karjadi, T.H., Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Tanuma, J., National Center for Global Health and Medicine, Tokyo, Japan; Oka, S., National Center for Global Health and Medicine, Tokyo, Japan; Nishijima, T., National Center for Global Health and Medicine, Tokyo, Japan; Choi, J.Y., Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Na, S., Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Kim, J.M., Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Gani, Y.M., Hospital Sungai Buloh, Sungai Buloh, Malaysia, Hospital Sungai Buloh, Sungai Buloh, Malaysia; Rudi, N.B., Hospital Sungai Buloh, Sungai Buloh, Malaysia; Azwa, I., University Malaya Medical Centre, Kuala Lumpur, Malaysia; Kamarulzaman, A., University Malaya Medical Centre, Kuala Lumpur, Malaysia; Syed Omar, S.F., University Malaya Medical Centre, Kuala Lumpur, Malaysia; Ponnampalavanar, S., University Malaya Medical Centre, Kuala Lumpur, Malaysia; Ditangco, R., Research Institute for Tropical Medicine, Muntinlupa City, Philippines; Pasayan, M.K., Research Institute for Tropical Medicine, Muntinlupa City, Philippines; Mationg, M.L., Research Institute for Tropical Medicine, Muntinlupa City, Philippines; Chan, Y.J., Taipei Veterans General Hospital, Taipei, Taiwan; Ku, W.W., Taipei Veterans General Hospital, Taipei, Taiwan; Wu, P.C., Taipei Veterans General Hospital, Taipei, Taiwan; Ke, E., Taipei Veterans General Hospital, Taipei, Taiwan; Ng, O.T., Tan Tock Seng Hospital, Singapore; Lim, P.L., Tan Tock Seng Hospital, Singapore; Lee, L.S., Tan Tock Seng Hospital, Singapore; Liang, D., Tan Tock Seng Hospital, Singapore; Avihingsanon, A., HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Gatechompol, S., HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Phanuphak, P., HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Phadungphon, C., HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Phuphuakrat, A., Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Chumla, L., Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Sanmeema, N., Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Chaiwarith, R., Research Institute for Health Sciences, Chiang Mai, Thailand; Sirisanthana, T., Research Institute for Health Sciences, Chiang Mai, Thailand; Praparattanapan, J., Research Institute for Health Sciences, Chiang Mai, Thailand; Nuket, K., Research Institute for Health Sciences, Chiang Mai, Thailand; Khusuwan, S., Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand, Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; Kantipong, P., Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; Kambua, P., Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; Nguyen, K.V., National Hospital for Tropical Diseases, Hanoi, Viet Nam; Bui, H.V., National Hospital for Tropical Diseases, Hanoi, Viet Nam; Nguyen, D.T.H., National Hospital for Tropical Diseases, Hanoi, Viet Nam; Nguyen, D.T., National Hospital for Tropical Diseases, Hanoi, Viet Nam; Do, C.D., Bach Mai Hospital, Hanoi, Viet Nam; Ngo, A.V., Bach Mai Hospital, Hanoi, Viet Nam; Nguyen, L.T., Bach Mai Hospital, Hanoi, Viet Nam; Sohn, A.H., TREAT Asia, amfAR - The Foundation for AIDS Research, Bangkok, Thailand; Ross, J.L., TREAT Asia, amfAR - The Foundation for AIDS Research, Bangkok, Thailand; Petersen, B., TREAT Asia, amfAR - The Foundation for AIDS Research, Bangkok, Thailand; Law, M.G., The Kirby Institute, UNSW SydneyNSW, Australia; Jiamsakul, A., Kirby Institute, UNSW, Sydney, Australia, The Kirby Institute, UNSW SydneyNSW, Australia; Bijker, R., The Kirby Institute, UNSW SydneyNSW, Australia; Rupasinghe, D., The Kirby Institute, UNSW SydneyNSW, Australia; TREAT Asia HIV Observational Database (TAHOD) of the International Epidemiology Databases to Evaluate AIDS (IeDEA) Asia-Pacific Group |
INTRODUCTION: Data on HIV treatment outcomes in people who inject drugs (PWID) in the Asia-Pacific are sparse despite the high burden of drug use. We assessed immunological and virological responses, AIDS-defining events and mortality among PWID receiving antiretroviral therapy (ART). METHODS: We investigated HIV treatment outcomes among people who acquired HIV via injecting drug use in the TREAT Asia HIV Observational Database (TAHOD) between January 2003 and March 2019. Trends in CD4 count and viral suppression (VS, HIV viral load <1000 copies/mL) were assessed. Factors associated with mean CD4 changes were analysed using repeated measures linear regression, and combined AIDS event and mortality were analysed using survival analysis. RESULTS: Of 622 PWID from 12 countries in the Asia-Pacific, 93% were male and the median age at ART initiation was 31 years (IQR, 28 to 34). The median pre-ART CD4 count was 71 cells/µL. CD4 counts increased over time, with a mean difference of 401 (95% CI, 372 to 457) cells/µL at year-10 (n = 78). Higher follow-up HIV viral load and pre-ART CD4 counts were associated with smaller increases in CD4 counts. Among 361 PWID with ≥1 viral load after six months on ART, proportions with VS were 82%, 88% and 93% at 2-, 5- and 10-years following ART initiation. There were 52 new AIDS-defining events and 50 deaths during 3347 person-years of follow-up (PYS) (incidence 3.05/100 PYS, 95% CI, 2.51 to 3.70). Previous AIDS or TB diagnosis, lower current CD4 count and adherence <95% were associated with combined new AIDS-defining event and death. CONCLUSIONS: Despite improved outcomes over time, our findings highlight the need for rapid ART initiation and adherence support among PWID within Asian settings. © 2021 The Authors. Journal of the International AIDS Society published by John Wiley & Sons Ltd on behalf of the International AIDS Society. |
Asia-Pacific; CD4 recovery; HIV/AIDS; people who inject drugs; treatment outcomes; tuberculosis; viral suppression |
nonnucleoside reverse transcriptase inhibitor; proteinase inhibitor; anti human immunodeficiency virus agent; drug; acquired immune deficiency syndrome; adult; all cause mortality; antiretroviral therapy; Article; Asia; CD4 lymphocyte count; cohort analysis; coinfection; female; follow up; hepatitis B; hepatitis C; human; Human immunodeficiency virus; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; incidence; injection drug user; longitudinal study; major clinical study; male; survival analysis; treatment outcome; tuberculosis; virus load; Human immunodeficiency virus infection; treatment outcome; Anti-HIV Agents; Asia; CD4 Lymphocyte Count; Cohort Studies; HIV Infections; Humans; Longitudinal Studies; Male; Pharmaceutical Preparations; Treatment Outc |
John Wiley and Sons Inc |
17582652 |
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34021711 |
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Q1 |
2724 |
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