No records
|
821 |
Wanandi S.I., Arumsari S., Afitriyansyah E., Syahrani R.A., Dewantara I.R., Nurachman L.A., Amin I.F., Haryono P.D., Budiman K., Sugiharta A.J., Remedika A.A., Taufikulhakim F.H., Iswanti F.C., Lee J.Y., Banerjee D. |
36099320700;57193202336;57223005545;57204103147;57223018344;57222663184;57188973524;57223016376;57223010670;57223013711;57223000993;57222619312;57192920851;57223019852;7202633380; |
Elevated extracellular co2 level affects the adaptive transcriptional response and survival of human peripheral blood mononuclear cells toward hypoxia and oxidative stress |
2021 |
Medical Journal of Indonesia |
30 |
1 |
|
5 |
12 |
|
1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104485331&doi=10.13181%2fmji.oa.203810&partnerID=40&md5=bf8dedf67718ab440cf4f665b5af2f83 |
Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Molecular Biology and Proteomics Core Facilities, Indonesian Medical and Education Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Biomedical Science Master Program, Rutgers-Robert Wood Johnson Medical SchoolNJ, United States; USAID Research Innovation Fellowship 2017, Washington, DC, United States; Department of Pharmacology, Rutgers-Robert Wood Johnson Medical SchoolNJ, United States |
Wanandi, S.I., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Molecular Biology and Proteomics Core Facilities, Indonesian Medical and Education Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Arumsari, S., Molecular Biology and Proteomics Core Facilities, Indonesian Medical and Education Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Afitriyansyah, E., Molecular Biology and Proteomics Core Facilities, Indonesian Medical and Education Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Syahrani, R.A., Molecular Biology and Proteomics Core Facilities, Indonesian Medical and Education Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Dewantara, I.R., Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Nurachman, L.A., Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Amin, I.F., Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Haryono, P.D., Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Budiman, K., Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sugiharta, A.J., Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Remedika, A.A., Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Taufikulhakim, F.H., Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Iswanti, F.C., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Molecular Biology and Proteomics Core Facilities, Indonesian Medical and Education Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Lee, J.Y., Biomedical Science Master Program, Rutgers-Robert Wood Johnson Medical SchoolNJ, United States, USAID Research Innovation Fellowship 2017, Washington, DC, United States; Banerjee, D., Department of Pharmacology, Rutgers-Robert Wood Johnson Medical SchoolNJ, United States |
BACKGROUND High carbon dioxide (CO2 ) level from indoor environments, such as classrooms and offices, might cause sick building syndrome. Excessive indoor CO2 level increases CO2 level in the blood, and over-accumulation of CO2 induces an adaptive response that requires modulation of gene expression. This study aimed to investigate the adaptive transcriptional response toward hypoxia and oxidative stress in human peripheral blood mononuclear cells (PBMCs) exposed to elevated CO2 level in vitro and its association with cell viability. METHODS PBMCs were treated in 5% CO2 and 15% CO2, representatives a high CO₂ level condition for 24 and 48 hours. Extracellular pH (pHe) was measured with a pH meter. The levels of reactive oxygen species were determined by measuring superoxide and hydrogen peroxide with dihydroethidium and dichlorofluorescin-diacetate assay. The mRNA expression levels of hypoxia-inducible factor (HIF)-1α, HIF-2α, nuclear factor (NF)-κB, and manganese superoxide dismutase (MnSOD) were analyzed using a real-time reverse transcriptase-polymerase chain reaction (qRT-PCR). Cell survival was determined by measuring cell viability. RESULTS pHe increased in 24 hours after 15% CO₂ treatment, and then decreased in 48 hours. Superoxide and hydrogen peroxide levels increased after the 24-and 48-hour of high CO₂ level condition. The expression levels of NF-κB, MnSOD, HIF-1α, and HIF-2α decreased in 24 hours and increased in 48 hours. The increased antioxidant mRNA expression in 48 hours showed that the PBMCs were responsive under high CO2 conditions. Elevated CO2 suppressed cell viability significantly in 48 hours. CONCLUSIONS After 48 hours of high CO₂ level condition, PBMCs showed an upregulation in genes related to hypoxia and oxidative stress to overcome the effects of CO2 elevation. © 2021 Authors. |
Elevated CO2; Extracellular pH; Oxidative stress; PBMC; Reactive oxygen species |
carbon dioxide; hydroethidine; hypoxia inducible factor 1alpha; hypoxia inducible factor 2alpha; immunoglobulin enhancer binding protein; manganese superoxide dismutase; messenger RNA; reactive oxygen metabolite; adult; Article; cell survival; cell viability; controlled study; extracellular space; gene expression; genetic transcription; human; human cell; human experiment; hypoxia; male; mRNA expression level; normal human; oxidative stress; peripheral blood mononuclear cell; pH; real time reverse transcription polymerase chain reaction; upregulation; young adult |
Faculty of Medicine, Universitas Indonesia |
08531773 |
|
|
Article |
Q4 |
164 |
21905 |
|
|
822 |
Ramlan A.A.W., Ratnaningrum A., Marsaban A.H.M. |
57195941841;57223018172;57195383833; |
A randomized controlled trial of infraorbital block using ketamine 1% for intra-and postoperative analgesia in children for ambulatory cleft lip correction |
2021 |
Medical Journal of Indonesia |
30 |
1 |
|
33 |
38 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104479826&doi=10.13181%2fmji.oa.204395&partnerID=40&md5=c08932eaa2373ffcc535ff0eadd8e55b |
Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anesthesiology, Fatmawati General Hospital, Jakarta, Indonesia |
Ramlan, A.A.W., Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ratnaningrum, A., Department of Anesthesiology, Fatmawati General Hospital, Jakarta, Indonesia; Marsaban, A.H.M., Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND In Indonesia, cleft lip correction surgery is often done as a social program in remote areas with limited resources. This study aimed to assess the effectiveness of ketamine, a cheaper and more accessible alternative, as a local analgesia in infraorbital block and to determine the possibility of ketamine as an alternative local analgesic drug for intraoperative and postoperative periods. METHODS This was a randomized controlled trial in children aged 2 months to 5 years who underwent cleft lip correction surgery at Cipto Mangunkusumo Hospital in 2016. Subjects were randomly divided into two groups: ketamine and bupivacaine. Standard general anesthesia with endotracheal intubation was performed in each group. Bilateral intraoral infraorbital block was performed using ketamine 1% 0.5 ml or bupivacaine 0.25% 0.5 ml. Postoperative evaluation includes pain scores based on the face, leg, activity, cry, and consolability (FLACC) scale and analgesic duration. RESULTS A total of 36 subjects were enrolled in this study, with 18 in each group. Both groups received the same total amount of fentanyl addition intraoperatively (p = 1). The postoperative FLACC pain scale scores between the two groups were not different, with p>0.05 in every measurement. The mean duration of postoperative analgesia in the ketamine group was longer than the bupivacaine group (15–13.49 hours, p = 0.031). CONCLUSIONS Infraorbital block with 1% ketamine 0.5 mg/kg was similarly effective for intraoperative and postoperative analgesia but had a longer duration than that with 0.25% bupivacaine 0.5 ml in ambulatory cleft lip correction. © 2021 Authors. |
Cleft lip; Ketamine; Postoperative pain |
bupivacaine; epinephrine; fentanyl; ketamine; paracetamol; sevoflurane; Article; breathing rate; child; cleft lip; cleft palate; clinical article; controlled study; endotracheal intubation; female; FLACC scale; follow up; general anesthesia; hemodynamics; human; infant; infraorbital nerve; infraorbital nerve block; intraoperative period; male; nerve block; pain assessment; postoperative analgesia; postoperative pain; pulse rate; randomized controlled trial; single blind procedure; telephone interview; visual analog scale |
Faculty of Medicine, Universitas Indonesia |
08531773 |
|
|
Article |
Q4 |
164 |
21905 |
|
|
823 |
Sarika D.T., Louisa M., Rozaliyani A., Evelina, Susiyanti M. |
57223018187;41461551400;57203065912;57223007552;19640377300; |
Efficacy of adjuvant intrastromal and combination of intrastromal and intracameral voriconazole in aspergillus fumigatus-induced moderate fungal keratitis in rabbits |
2021 |
Medical Journal of Indonesia |
30 |
1 |
|
13 |
19 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104464172&doi=10.13181%2fmji.oa.203726&partnerID=40&md5=6021b6878c47eb4ccde69bba65f51abb |
Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Clinical Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Sarika, D.T., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of Clinical Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rozaliyani, A., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Evelina, Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Susiyanti, M., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND There is no in vivo evidence for the effectiveness of adjuvant intrastromal and combination of intrastromal and intracameral voriconazole (VCZ) for treating Aspergillus fumigatus keratitis. This study aimed to compare the efficacy of both agents against it. METHODS A randomized, masked, controlled experimental study was conducted on 11 albino New Zealand white rabbits in which moderate fungal keratitis was induced by inoculating spores of A. fumigatus to the cornea. The rabbits were allocated into 3 groups: 50 μg/0.1 ml intrastromal VCZ injection, 50 μg/0.1 ml intrastromal and intracameral VCZ injections, and topical VCZ (control). The treatment was given 5 days after inoculation. Epithelial defect, infiltrate size, corneal ulcer depth, and hypopyon were evaluated clinically. Histopathological and mycological examinations were also done 14 days after treatment. RESULTS All rabbits in the adjuvant treatment groups demonstrated a tendency of a better clinical response with decreasing size of epithelial defect (p = 0.679) and infiltrate (p = 0.755) than in the control group. Direct microscopy, corneal culture, and chop corneal tissue culture were still positive in most of the rabbits from all groups. Histopathological examination showed an increase of inflammatory cells after treatment in all groups, especially in rabbits which were inoculated with A. fumigatus spores in both eyes. CONCLUSIONS An adjuvant combination of intrastromal and intracameral VCZ showed a tendency of better clinical response for A. fumigatus-induced moderate fungal keratitis in rabbits. © 2021 Authors. |
Aspergillus fumigatus; Fungal keratitis; Intrastromal; Voriconazole |
eye drops; ketamine; pentobarbital; potassium hydroxide; prednisone acetate; tetracaine; voriconazole; xylazine; animal experiment; animal model; animal tissue; Article; Aspergillus fumigatus; controlled study; cornea injury; cornea ulcer; corneal scraping; disk diffusion; drug efficacy; follow up; fungal examination; histopathology; hypopyon; inflammation; intrastromal drug administration; keratectomy; keratomycosis; Leporidae; male; nonhuman; treatment response |
Faculty of Medicine, Universitas Indonesia |
08531773 |
|
|
Article |
Q4 |
164 |
21905 |
|
|
No records
|
5 |
Rahmat B., Dwita N.U., Arya Wardana P.W., Lilyasari O. |
57192273755;57402910300;57403605200;57192914838; |
Preoperative Left Ventricle End Diastolic Volume Index as a Predictor for Low Cardiac Output Syndrome After Surgical Closure of Secundum Atrial Septal Defect With Small-Sized Left Ventricle |
2021 |
Frontiers in Pediatrics |
9 |
|
705257 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122447256&doi=10.3389%2ffped.2021.705257&partnerID=40&md5=6da645c8d6ae19fd8dfd4e9dc9a05bcb |
Pediatric and Congenital Heart Surgery Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Centre Harapan Kita, Jakarta, Indonesia |
Rahmat, B., Pediatric and Congenital Heart Surgery Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Dwita, N.U., Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Arya Wardana, P.W., Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Lilyasari, O., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Centre Harapan Kita, Jakarta, Indonesia |
Introduction: Low cardiac output syndrome is one of the postoperative complications that are associated with significant morbidity and mortality after surgical closure of atrial septal defect (ASD) with small-sized left ventricle (LV). This study investigated whether preoperative left ventricular end-diastolic volume index (LVEDVi) could accurately predict low cardiac output syndrome (LCOS) after surgical closure of ASD with small-sized LV. Method: This retrospective cohort study involved adult ASD patients with small-sized LV from January 2018 to December 2019 in National Cardiovascular Center Harapan Kita. Preoperative MRI data to assess the left and right ventricle volume were collected. A bivariate analysis using independent Student's t-test was done. Diagnostic test using receiver operating characteristic (ROC) curve was also done to obtain the area under the curve (AUC) value. The best cutoff point was determined by Youden's index. Result: Fifty-seven subjects were involved in this study [age (mean ± SD) 32.56 ± 13.15 years; weight (mean ± SD) 48.82 ± 12.15 kg]. Subjects who had post-operative LCOS (n = 30) have significantly lower LVEDVi (45.0 ± 7.42 ml/m2 vs. 64.15 ± 13.37 ml/m2; p < 0.001), LVEDV (64.6 ± 16.0 ml vs. 85.9 ± 20.7 ml; p < 0.001), LVSV (38.97 ± 11.5 ml vs. 53.13 ± 7.5 ml; p < 0.001), and LVSVi (27.28 ± 8.55 ml/m2 vs. 37.42 ± 5.35 ml/m2; p < 0.001) compared to subjects who did not have post-operative LCOS (n = 27). ROC analysis showed that the best AUC was found on LVEDVi (AUC 95.3%; 95% confidence interval: 90.6–100%). The best cutoff value for LVEDVi to predict the occurrence of LCOS after surgical closure of ASD was 53.3 ml/m2 with a sensitivity of 86.7% and a specificity of 85.2%. Conclusion: This study showed that preoperative LVEDVi could predict LCOS after surgical closure of ASD with small-sized LV with a well-defined cutoff. The best cutoff value of LVEDVi to predict the occurrence of LCOS after surgical ASD closure was 53.5 ml/m2. Copyright © 2021 Rahmat, Dwita, Arya Wardana and Lilyasari. |
ASD closure; atrial septal defect; left ventricle end diastolic volume; low cardiac output syndrome; magnetic resonance imaging (MRI) |
|
Frontiers Media S.A. |
22962360 |
|
|
Article |
Q1 |
960 |
4641 |
|
|
6 |
Pranata R., Huang I., Lim M.A., Yonas E., Vania R., Lukito A.A., Nasution S.A., Siswanto B.B., Kuswardhani R.A.T. |
57201973901;57208576645;57216039756;57201987097;57208328436;57213835420;57189373134;14422648800;36863900500; |
Elevated De Ritis Ratio Is Associated With Poor Prognosis in COVID-19: A Systematic Review and Meta-Analysis |
2021 |
Frontiers in Medicine |
8 |
|
676581 |
|
|
|
1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122327729&doi=10.3389%2ffmed.2021.676581&partnerID=40&md5=254957cc5c17b448a803a88e33741d8f |
Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Faculty of Medicine, Department of Internal Medicine, Hasan Sadikin General Hospital, Universitas Padjadjaran, Bandung, Indonesia; Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Faculty of Medicine, Division of Plastic, Reconstructive, and Aesthetic, Department of Surgery, Sanglah General Hospital, Udayana University, Jimbaran, Indonesia; Department of Cardiology and Vascular Medicine, Siloam Hospitals Lippo Village, Tangerang, Indonesia; Faculty of Medicine, Division of Cardiology, Department of Internal Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Faculty of Medicine, Department of Cardiology and Vascular Medicine, National Cardiovascular Center Harapan Kita, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Division of Geriatrics, Department of Internal Medicine, Sanglah Teaching Hospital, Udayana University, Denpasar, Indonesia |
Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Huang, I., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Faculty of Medicine, Department of Internal Medicine, Hasan Sadikin General Hospital, Universitas Padjadjaran, Bandung, Indonesia; Lim, M.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Yonas, E., Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Vania, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Faculty of Medicine, Division of Plastic, Reconstructive, and Aesthetic, Department of Surgery, Sanglah General Hospital, Udayana University, Jimbaran, Indonesia; Lukito, A.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Department of Cardiology and Vascular Medicine, Siloam Hospitals Lippo Village, Tangerang, Indonesia; Nasution, S.A., Faculty of Medicine, Division of Cardiology, Department of Internal Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Siswanto, B.B., Faculty of Medicine, Department of Cardiology and Vascular Medicine, National Cardiovascular Center Harapan Kita, Universitas Indonesia, Jakarta, Indonesia; Kuswardhani, R.A.T., Faculty of Medicine, Division of Geriatrics, Department of Internal Medicine, Sanglah Teaching Hospital, Udayana University, Denpasar, Indonesia |
Objective: This meta-analysis aims to assess whether elevated De Ritis ratio is associated with poor prognosis in patients with coronavirus 2019 (COVID-19). Methods: A systematic literature search was performed using PubMed, Embase, and EuropePMC databases up until September 17, 2021. De Ritis ratio is also known as Aspartate aminotransferase/alanine transaminase (AST/ALT) ratio. The main outcome was poor prognosis, a composite of mortality, severity, the need for ICU care, and intubation. The effect measure was odds ratios (ORs) and mean differences. We generated sensitivity and specificity, negative and positive likelihood ratio (NLR and PLR), diagnostic odds ratio (DOR), and area under curve (AUC). Results: There were eight studies with 4,606 patients. De Ritis ratio was elevated in 44% of the patients. Patients with poor prognosis have higher De Ritis ratio [mean difference 0.41 (0.31, 0.50), p < 0.001; I2: 81.0%] and subgroup analysis showed that non-survivors also have higher De Ritis Ratio [mean difference 0.47 (0.46, 0.48), p < 0.001; I2: 0%]. Elevated De Ritis ratio was associated with poor prognosis [OR 3.28 (2.39, 4.52), p < 0.001; I2: 35.8%]. It has a sensitivity of 55% (36–73), specificity of 71% (52–85), PLR 1.9, NLR.63, DOR of 3 (2–4), and AUC of.67 (0.63–0.71). The posterior probability of poor prognosis was 38% if De Ritis is elevated, while 17% if De Ritis is not elevated. Conclusion: Elevated De Ritis ratio is associated with poor prognosis in patients with COVID-19. Systematic Review Registration: PROSPERO ID: CRD42020216634. Copyright © 2021 Pranata, Huang, Lim, Yonas, Vania, Lukito, Nasution, Siswanto and Kuswardhani. |
coronavirus—COVID-19; De Ritis ratio; liver enzyme; SARS-CoV-2; transaminase |
|
Frontiers Media S.A. |
2296858X |
|
|
Review |
Q1 |
1388 |
2608 |
|
|
7 |
Wisnu W., Alwi I., Nafrialdi N., Harimurti K., Pemayun T.G.D., Jusman S.W.A., Santoso D.I.S., Harahap A.R., Suwarto S., Subekti I. |
57200425452;15055173800;57395824800;23473513200;57208091289;36518792100;6604001213;57395521700;8443626100;24336854300; |
The Differential Effects of Propylthiouracil and Methimazole as Graves’ Disease Treatment on Vascular Atherosclerosis Markers: A Randomized Clinical Trial |
2021 |
Frontiers in Endocrinology |
12 |
|
796194 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122186237&doi=10.3389%2ffendo.2021.796194&partnerID=40&md5=f92b3a12a849c6a2e102b7358c8abd20 |
Division of Endocrine, Metabolism and Di, abetes, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Division of Endocrine, Metabolism, and Diabetes, Department of Internal Medicine, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Physiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Wisnu, W., Division of Endocrine, Metabolism and Di, abetes, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Alwi, I., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Nafrialdi, N., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Harimurti, K., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Pemayun, T.G.D., Division of Endocrine, Metabolism, and Diabetes, Department of Internal Medicine, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Jusman, S.W.A., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Santoso, D.I.S., Department of Medical Physiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Harahap, A.R., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Suwarto, S., Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Subekti, I., Division of Endocrine, Metabolism and Di, abetes, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Background: Hyperthyroidism is related to vascular atherosclerosis. Propylthiouracil (PTU) and methimazole, other than their antithyroid effects, may have different mechanisms in preventing atherogenesis in Graves’ disease. Objective: This study aimed to investigate the effect of antithyroid drugs on markers of vascular atherosclerosis in Graves’ hyperthyroidism. Methods: This study was a single-blind, randomized clinical trial conducted on 36 patients with Graves’ disease in Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, from June 2019 until July 2020. Graves’ disease was diagnosed from clinical manifestation of hyperthyroidism with diffuse goiter and then confirmed by thyroid stimulation hormone (TSH), free T4 (fT4), and TSH-receptor antibody (TRAb) measurements. Participants were randomly assigned to either a PTU or a methimazole treatment group and followed up for 3 months. Markers of vascular atherosclerosis were represented by adhesion molecules [intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin], carotid artery stiffness [pulse wave velocity (PWV)], and thickness [carotid intima media thickness (cIMT)]. Results: By the end of the study, 24 participants reached euthyroid condition (13 from the PTU group and 11 from the methimazole group). After 3 months of follow-up, in the PTU group, we noticed an improvement of ICAM-1 [pretreatment: 204.1 (61.3) vs. posttreatment: 141.6 (58.4) ng/ml; p = 0.001], VCAM-1 [837 (707–977) vs. 510 (402–630) ng/ml; p < 0.001] and E-selectin [32.1 (24.1–42.7) vs. 28.2 (21.6–36.8) ng/ml; p = 0.045] in the PTU group. In the methimazole group, only VCAM-1 improvement [725 (565–904) vs. 472 (367–590); p = 0.001] was observed. Meanwhile, we found no significant changes in PWV or cIMT in either group. Conclusion: Antithyroid treatment in Graves’ disease leads to improvement in adhesion molecules, with a lesser effect on methimazole, whereas there were no significant changes in PWV or cIMT. PTU may have a better mechanism compared with methimazole in terms of improving adhesion molecules. Copyright © 2021 Wisnu, Alwi, Nafrialdi, Harimurti, Pemayun, Jusman, Santoso, Harahap, Suwarto and Subekti. |
adhesion molecules; carotid intima media thickness; Graves’ disease; hyperthyroidism; methimazole; propylthiouracil; pulse wave velocity; vascular atherosclerosis |
cell adhesion molecule 1; endothelial leukocyte adhesion molecule 1; propylthiouracil; thiamazole; thyrotropin; adolescent; adult; arterial stiffness; Article; atherosclerosis; blood pressure; clinical article; controlled study; coronavirus disease 2019; echography; electrochemiluminescence immunoassay; enzyme linked immunosorbent assay; female; follow up; Graves disease; human; hyperthyroidism; inflammation; male; middle aged; physical examination; pregnancy; pulse wave velocity; randomized controlled trial; young adult |
Frontiers Media S.A. |
16642392 |
|
|
Article |
Q1 |
1518 |
2233 |
|
|
85 |
Wiguna T., Minayati K., Kaligis F., Ismail R.I., Wijaya E., Murtani B.J., Pradana K. |
24367785700;57218681686;36604651700;55996895500;57358945000;57216652176;57220165625; |
The Effect of Cyberbullying, Abuse, and Screen Time on Non-suicidal Self-Injury Among Adolescents During the Pandemic: A Perspective From the Mediating Role of Stress |
2021 |
Frontiers in Psychiatry |
12 |
|
743329 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120410832&doi=10.3389%2ffpsyt.2021.743329&partnerID=40&md5=721d9aa51662421c0092a11d6eaf48a8 |
Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Faculty of Psychology, Universitas Tarumanegara, Jakarta, Indonesia |
Wiguna, T., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Minayati, K., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Kaligis, F., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Ismail, R.I., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Wijaya, E., Faculty of Psychology, Universitas Tarumanegara, Jakarta, Indonesia; Murtani, B.J., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Pradana, K., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Adolescence is often a period of turmoil. The COVID-19 pandemic has increased adolescents' difficulty due to mental health consequences that may affect their developmental milestones. This study constructed and empirically tested a theoretical model of three predictive factors (cyberbullying, abuse, and screen time) and stress as the mediating factor in adolescent non-suicidal self-injury (NSSI). Structural equation model (SEM) analysis was applied to investigate stress as a mediating factor in the relationship between adolescent NSSI and cyberbullying, abuse, and screen time. This cross-sectional study used a “crowdsourcing” sample collection method to recruit 464 adolescents aged 11–17 years who were administered a questionnaire comprising scales on cyberbullying, abuse, screen time, stress, and NSSI. All scales had construct reliabilities ranging from 0.759 to 0.958. SEM statistical analysis was performed using Lisrel version 8.8 (Scientific Software International, USA) for Windows (Microsoft Corporation, Redmond, WA, USA). The mean (± SD) age of the cohort was 14.61 ± 1.65 years, and consisted of 66.7% females. Secondary high school was the highest educational background (58%). The study found that cyberbullying and abuse were direct positive predictors (critical t-value for the path > 1.96; p < 0.05) of adolescent NSSI; however, screen time did not have any direct relationship. Furthermore, stress was a significant full mediating factor of screen time and a partial mediating factor of cyberbullying and abuse in the relationship with adolescent NSSI (critical t-value of the path = 5.27; p < 0.05). Cyberbullying, screen time, and abuse with the mediating effect of stress could explain 48% of the variance in adolescent NSSI (R2 = 0.48). Adolescent mental health prevention and promotion programs need to be redesigned during the current COVID-19 pandemic to manage their stress and minimize the mental health consequences of cyberbullying, abuse, and inappropriately increased screen time. Copyright © 2021 Wiguna, Minayati, Kaligis, Ismail, Wijaya, Murtani and Pradana. |
abuse; adolescents; COVID-19; cyberbullying; Indonesia; non-suicidal self-injury; screen time; stress |
abuse; adolescent; Article; automutilation; coronavirus disease 2019; cross-sectional study; cyberbullying; educational status; female; health program; human; male; mental health; pandemic; physiological stress; prediction; questionnaire; screen time |
Frontiers Media S.A. |
16640640 |
|
|
Article |
Q1 |
1363 |
2668 |
|
|
88 |
Lokeswara A.W., Hiksas R., Irwinda R., Wibowo N. |
57200937543;57226152029;57205713130;15049026900; |
Preeclampsia: From Cellular Wellness to Inappropriate Cell Death, and the Roles of Nutrition |
2021 |
Frontiers in Cell and Developmental Biology |
9 |
|
726513 |
|
|
|
2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119532670&doi=10.3389%2ffcell.2021.726513&partnerID=40&md5=38456382efeb541572619e5bed470318 |
Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia |
Lokeswara, A.W., Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Hiksas, R., Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Irwinda, R., Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Wibowo, N., Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia |
Preeclampsia is one of the most common obstetrical complications worldwide. The pathomechanism of this disease begins with abnormal placentation in early pregnancy, which is associated with inappropriate decidualization, vasculogenesis, angiogenesis, and spiral artery remodeling, leading to endothelial dysfunction. In these processes, appropriate cellular deaths have been proposed to play a pivotal role, including apoptosis and autophagy. The proper functioning of these physiological cell deaths for placentation depends on the wellbeing of the trophoblasts, affected by the structural and functional integrity of each cellular component including the cell membrane, mitochondria, endoplasmic reticulum, genetics, and epigenetics. This cellular wellness, which includes optimal cellular integrity and function, is heavily influenced by nutritional adequacy. In contrast, nutritional deficiencies may result in the alteration of plasma membrane, mitochondrial dysfunction, endoplasmic reticulum stress, and changes in gene expression, DNA methylation, and miRNA expression, as well as weakened defense against environmental contaminants, hence inducing a series of inappropriate cellular deaths such as abnormal apoptosis and necrosis, and autophagy dysfunction and resulting in abnormal trophoblast invasion. Despite their inherent connection, the currently available studies examined the functions of each organelle, the cellular death mechanisms and the nutrition involved, both physiologically in the placenta and in preeclampsia, separately. Therefore, this review aims to comprehensively discuss the relationship between each organelle in maintaining the physiological cell death mechanisms and the nutrition involved, and the interconnection between the disruptions in the cellular organelles and inappropriate cell death mechanisms, resulting in poor trophoblast invasion and differentiation, as seen in preeclampsia. Copyright © 2021 Lokeswara, Hiksas, Irwinda and Wibowo. |
apoptosis; autophagy; cell death; cellular wellness; nutrition; preeclampsia |
aneuploidy; cell death; cell differentiation; cell invasion; cell membrane; cell organelle; endoplasmic reticulum; endoplasmic reticulum stress; environmental factor; epigenetics; gene expression; human; mitochondrion; nonhuman; nutrition; preeclampsia; pregnancy; Review; trophoblast; vascular remodeling |
Frontiers Media S.A. |
2296634X |
|
|
Review |
Q1 |
2452 |
946 |
|
|
89 |
Elbarbary N.S., dos Santos T.J., de Beaufort C., Wiltshire E., Pulungan A., Scaramuzza A.E. |
35725405100;37080460700;55346159500;6603809910;57192905981;6602617288; |
The Challenges of Managing Pediatric Diabetes and Other Endocrine Disorders During the COVID-19 Pandemic: Results From an International Cross-Sectional Electronic Survey |
2021 |
Frontiers in Endocrinology |
12 |
|
735554 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119406902&doi=10.3389%2ffendo.2021.735554&partnerID=40&md5=0764f19be86686d381fa20013b41f50b |
Diabetes Unit, Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Instituto Hispalense de Pediatría, Vithas Almería, Almería, Spain; Department of Preventive Medicine and Public Health, Universidad Autónoma de Madrid, Madrid, Spain; Diabetes Endocrine Care Clinique Pédiatrique (DECCP), Clinique Pédiatrique/Centre Hospitalier (CH) de Luxembourg, Luxembourg; Department Pediatric Endocrinology, Free University Hospital Brussels, Brussels, Belgium; Department of Paediatrics and Child Health, University of Otago Wellington, Wellington, New Zealand; Department of Child Health, Capital and Coast District Health Board, Wellington, New Zealand; Child Health Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Diabetes and Endocrinology Nutrition, Division of Pediatrics, Azienda Socio Sanitaria Territoriale (ASST) Cremona, “Ospedale Maggiore di Cremona”, Cremona, Italy |
Elbarbary, N.S., Diabetes Unit, Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt; dos Santos, T.J., Instituto Hispalense de Pediatría, Vithas Almería, Almería, Spain, Department of Preventive Medicine and Public Health, Universidad Autónoma de Madrid, Madrid, Spain; de Beaufort, C., Diabetes Endocrine Care Clinique Pédiatrique (DECCP), Clinique Pédiatrique/Centre Hospitalier (CH) de Luxembourg, Luxembourg, Department Pediatric Endocrinology, Free University Hospital Brussels, Brussels, Belgium; Wiltshire, E., Department of Paediatrics and Child Health, University of Otago Wellington, Wellington, New Zealand, Department of Child Health, Capital and Coast District Health Board, Wellington, New Zealand; Pulungan, A., Child Health Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Scaramuzza, A.E., Diabetes and Endocrinology Nutrition, Division of Pediatrics, Azienda Socio Sanitaria Territoriale (ASST) Cremona, “Ospedale Maggiore di Cremona”, Cremona, Italy |
Background: Frequency, dimensions, management, and outcomes of the COVID-19 pandemic in children with endocrine disorders and diabetes were assessed. Methods: A cross-sectional electronic survey was distributed to the global network of endocrine societies. Respondents’ professional and practice profiles, clinic sizes, their country of practice, and the impact of COVID-19 on endocrine diseases were investigated. Results: Respondents from 131 pediatric endocrine centers in 51 countries across all continents completed the survey. Routine check-ups and education were altered in most pediatric endocrine clinics. Over 20% of clinics experienced a shortage of critical medications or essential supplies. ICU treatment was required for patients with diabetes and COVID-19 in 21.2% of centers. In diabetes, 44% of respondents reported increased diabetic ketoacidosis episodes in newly diagnosed cases and 30% in established cases. Biopsychosocial and behavioral changes were explicitly reported to be occurring among pediatric patients with endocrine disorders. Conclusions: This large global survey conducted during the COVID-19 pandemic highlights that diabetes is more challenging to manage than any other pediatric endocrine disorder, with an increased risk of morbidity. Psychological distress due to COVID-19 needs to be recognized and addressed. The importance of close contact with healthcare professionals should be emphasized, and medical supplies should be readily available to all patients. © Copyright © 2021 Elbarbary, dos Santos, de Beaufort, Wiltshire, Pulungan and Scaramuzza. |
adrenal; children; COVID-19; diabetes; growth; obesity and metabolic syndrome; puberty; thyroid |
anemia; anxiety; Article; behavior change; bone metabolism; child; clinical practice; coronavirus disease 2019; cross-sectional study; depression; diabetes mellitus; diabetic ketoacidosis; eating disorder; education; endocrine disease; female; gender dysphoria; genetic screening; glucose blood level; glycemic control; human; insulin dependent diabetes mellitus; insulin treatment; major clinical study; male; mental stress; metabolic syndrome X; morbidity; pandemic; pediatric patient; pharmacist; physical activity; preschool child; questionnaire; school child; suicide attempt; teleconsultation; thyroid disease |
Frontiers Media S.A. |
16642392 |
|
|
Article |
Q1 |
1518 |
2233 |
|
|