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118 |
Sen L.T., Siste K., Hanafi E., Murtani B.J., Christian H., Limawan A.P., Adrian, Siswidiani L.P. |
57219034101;55644113100;56737010600;57216652176;57209266195;57202712511;57216932703;57219029296; |
Insights Into Adolescents' Substance Use in a Low–Middle-Income Country During the COVID-19 Pandemic |
2021 |
Frontiers in Psychiatry |
12 |
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739698 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118257704&doi=10.3389%2ffpsyt.2021.739698&partnerID=40&md5=9b8aba71c0b6aaab6c7e81012e3c8927 |
Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Sen, L.T., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Siste, K., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Hanafi, E., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Murtani, B.J., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Christian, H., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Limawan, A.P., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Adrian, Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Siswidiani, L.P., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Introduction: The COVID-19 pandemic and its lockdown have been a significant life event for many individuals, particularly adolescents. The immense psychological pressure could drive risky behavior, e.g., substance use, while lockdown might lead to decreased use. This study aimed to observe the change in substance use among adolescents in Indonesia and the moderating variables to consumption during the COVID-19 lockdown period. Methods: This study utilized an online survey from April 28, 2020 to June 30, 2020. The hyperlink was disseminated to school administrators and parenting groups through social media and direct messages. A total of 2,932 adolescents (17.4 ± 2.24 and 78.7% females) submitted valid responses. The survey was comprised of a sociodemographic section, substance use details, and psychometric sections, including the Alcohol Use Disorders Identification Test (AUDIT), Cigarette Dependence Scale 12 (CDS-12), Pittsburgh Sleep Quality Index (PSQI), and Strength and Difficulties Questionnaire (SDQ). Results: Overall, adolescent alcohol use during the pandemic was 5.1%, cigarette smoking was 3.1%, and drug consumption was 0.4%. Over half (53.4%) of alcohol drinkers reported increased drinking, and 33.1% had harmful or dependence-like drinking behavior; in contrast, 44.4% of adolescent smokers disclosed reduced cigarette consumption. Around 37.8% of the drug users indicated increased use. During the pandemic, adolescent alcohol use was associated with higher education [adjusted odds ratio (AOR) = 2.67, 95% confidence interval (CI) 1.02–4.86, p = 0.04], higher AUDIT scores (AOR = 1.33, 95% CI 1.25–1.42, p < 0.001), and very low prosocial behavior (AOR = 2.46, 95% CI 1.52–3.88, p < 0.001). Cigarette smoking was correlated with male sex (AOR = 9.56, 95% CI 5.64–16.62, p < 0.001), age (AOR = 1.40, 95% CI 1.14–1.75, p < 0.001), and higher CDS score (AOR = 1.17, 95% CI 1.13–1.20, p < 0.001). Conclusions: Rates of adolescent substance use were significant, with sizeable proportions reporting higher usage. This appeared to occur predominantly in specific demographics and those with a lower protective psychosocial attribute, i.e., prosocial behavior, during the lockdown. These findings should urge the strengthening of adolescent addiction care during and after the pandemic. © Copyright © 2021 Sen, Siste, Hanafi, Murtani, Christian, Limawan, Adrian and Siswidiani. |
adolescent; alcohol; cigarette; COVID-19; drugs; Indonesia |
adolescent; Alcohol Use Disorders Identification Test; Article; Cigarette Dependence Scale 12; cigarette smoking; controlled study; coronavirus disease 2019; demography; descriptive research; educational status; female; health care survey; human; Indonesia; low income country; major clinical study; male; mental disease assessment; middle income country; online analysis; pandemic; Pittsburgh Sleep Quality Index; prevalence; prosocial behavior; psychometry; sex difference; social media; social status; Strength and Difficulties Questionnaire; substance use |
Frontiers Media S.A. |
16640640 |
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122 |
Panigoro S.S., Sutandyo N., Witjaksono F., Siregar N.C., Ramli R., Hariani R., Pangarsa E.A., Prajoko Y.W., Puruhita N., Hamdani W., Bayu D., Madjid M., Yulidar D., Fransiska J.E., Widyawati R., Tripriadi E.S., Wiwit Ade F.W., Yunda D.K., Pranata R. |
56790104300;26028099200;57070455800;6508087790;56126010900;57211658330;57204907532;56050815500;57224902090;57211471316;57193199487;57311861300;57312306100;57197735128;57312525600;57312968000;57312306200;57312748700;57201973901; |
The Association Between Triglyceride-Glucose Index as a Marker of Insulin Resistance and the Risk of Breast Cancer |
2021 |
Frontiers in Endocrinology |
12 |
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745236 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117891585&doi=10.3389%2ffendo.2021.745236&partnerID=40&md5=7c6ce4b0ece5dc9224c11aab644ae33c |
Department of Surgical Oncology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Hematology and Medical Oncology, Dharmais Hospital National Cancer Center, Jakarta, Indonesia; Department of Nutrition, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pathological Anatomy, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Surgical Oncology, Dharmais Hospital National Cancer Center, Jakarta, Indonesia; Department of Nutrition, Dharmais Hospital National Cancer Center, Jakarta, Indonesia; Department of Hematology and Medical Oncology, Dr. Kariadi General Hospital, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Department of Surgical Oncology, Dr. Kariadi General Hospital, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Department of Nutrition, Dr. Kariadi General Hospital, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Department of Surgical Oncology, Wahidin Sudirohusodo General Hospital, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Division of Hematology-Medical Oncology, Department of Internal Medicine, Hasanuddin University General Hospital, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Department of Nutrition, Faculty of Medicine, Wahidin Sudirohusodo General Hospital, Hasanuddin University, Makassar, Indonesia; Department of Surgical Oncology, Dr. WZ Johannes General Hospital, Kupang, Indonesia; Division of Hematology and Medical Oncology, Department of Internal Medicine, Dr. WZ Johannes General Hospital, Kupang, Indonesia; Department of Pathological Anatomy, Dr. WZ Johannes General Hospital, Kupang, Indonesia; Department of Surgical Oncology, Arifin Achmad General Hospital, Faculty of Medicine, Riau University, Pekanbaru, Indonesia; Department of Pathological Anatomy, Arifin Achmad General Hospital, Faculty of Medicine, Riau University, Pekanbaru, Indonesia; Department of Nutrition, Arifin Achmad General Hospital, Faculty of Medicine, Riau University, Pekanbaru, Indonesia; Department of Nutrition, Nutrition Cancer Reaserch Team, Dharmais Hospital National Cancer Center, Jakarta, Indonesia |
Panigoro, S.S., Department of Surgical Oncology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sutandyo, N., Department of Hematology and Medical Oncology, Dharmais Hospital National Cancer Center, Jakarta, Indonesia; Witjaksono, F., Department of Nutrition, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Siregar, N.C., Department of Pathological Anatomy, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ramli, R., Department of Surgical Oncology, Dharmais Hospital National Cancer Center, Jakarta, Indonesia; Hariani, R., Department of Nutrition, Dharmais Hospital National Cancer Center, Jakarta, Indonesia; Pangarsa, E.A., Department of Hematology and Medical Oncology, Dr. Kariadi General Hospital, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Prajoko, Y.W., Department of Surgical Oncology, Dr. Kariadi General Hospital, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Puruhita, N., Department of Nutrition, Dr. Kariadi General Hospital, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Hamdani, W., Department of Surgical Oncology, Wahidin Sudirohusodo General Hospital, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Bayu, D., Division of Hematology-Medical Oncology, Department of Internal Medicine, Hasanuddin University General Hospital, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Madjid, M., Department of Nutrition, Faculty of Medicine, Wahidin Sudirohusodo General Hospital, Hasanuddin University, Makassar, Indonesia; Yulidar, D., Department of Surgical Oncology, Dr. WZ Johannes General Hospital, Kupang, Indonesia; Fransiska, J.E., Division of Hematology and Medical Oncology, Department of Internal Medicine, Dr. WZ Johannes General Hospital, Kupang, Indonesia; Widyawati, R., Department of Pathological Anatomy, Dr. WZ Johannes General Hospital, Kupang, Indonesia; Tripriadi, E.S., Department of Surgical Oncology, Arifin Achmad General Hospital, Faculty of Medicine, Riau University, Pekanbaru, Indonesia; Wiwit Ade, F.W., Department of Pathological Anatomy, Arifin Achmad General Hospital, Faculty of Medicine, Riau University, Pekanbaru, Indonesia; Yunda, D.K., Department of Nutrition, Arifin Achmad General Hospital, Faculty of Medicine, Riau University, Pekanbaru, Indonesia; Pranata, R., Department of Nutrition, Nutrition Cancer Reaserch Team, Dharmais Hospital National Cancer Center, Jakarta, Indonesia |
Background: This study aims to evaluate the association and dose-response between triglyceride-glucose (TyG) index and breast cancer. Method: This is a multicenter case-control study conducted in six public referral hospitals in Indonesia. Cases are individuals aged 19 years or above who were diagnosed with breast cancer within 1 year of diagnosis, based on histopathology and immunohistochemistry. Controls were recruited from corresponding hospitals. TyG index was determined by the formula: ln (fasting TG [mg/dl] × fasting glucose [mg/dl]). Results: There were 212 participants in the breast cancer group and 212 participants in the control group. TyG index was higher in patients with breast cancer (median 8.65 [7.38, 10.9] vs. 8.30 [7.09, 10.84], p < 0.001). When compared with TyG quartile of Q1, Q4 was associated with an OR of 2.42 (1.77, 3.31), p < 0.001, Q3 was associated with an OR of 1.53 (1.21, 1.93), p < 0.001, Q2 was associated with an OR of 1.39 (1.12, 1.73), p = 0.002 for the risk of breast cancer. The dose-response relationship was nonlinear (p < 0.001). On univariate analysis, smoking (OR 2.15 [1.44, 3.22], p < 0.001), use of contraception (1.73 [1.15, 2.60], p = 0.008), alcohol consumption (OR 2.04 [0.96, 4.35], p = 0.064), and TyG Index >8.87 (OR 3.08 [1.93, 4.93], p < 0.001) were associated with risk of breast cancer. Independently associated with increased risk of breast cancer included smoking (OR 1.93 [1.23, 3.01], p = 0.004), use of contraception (OR 1.59 [1.02, 2.48], p = 0.039), and TyG Index >8.87 (OR 2.93 [1.72, 4.98], p < 0.001) Conclusion: TyG index was associated with breast cancer in a nonlinear dose-response fashion. © Copyright © 2021 Panigoro, Sutandyo, Witjaksono, Siregar, Ramli, Hariani, Pangarsa, Prajoko, Puruhita, Hamdani, Bayu, Madjid, Yulidar, Fransiska, Widyawati, Tripriadi, F. W., Yunda and Pranata. |
breast cancer; glucose; insulin; insulin resistance; triglyceride |
insulin; triacylglycerol; adult; aged; alcohol consumption; Article; breast cancer; breast feeding; case control study; contraception; controlled study; dose response; female; glucose blood level; histopathology; human; human tissue; immunohistochemistry; major clinical study; multicenter study; nutrient uptake; obesity; questionnaire; smoking; triacylglycerol blood level; underweight; univariate analysis |
Frontiers Media S.A. |
16642392 |
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Article |
Q1 |
1518 |
2233 |
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171 |
Pudjiadi A.H., Putri N.D., Sjakti H.A., Yanuarso P.B., Gunardi H., Roeslani R.D., Pasaribu A.D., Nurmalia L.D., Sambo C.M., Ugrasena I.D.G., Soeroso S., Firman A., Muryawan H., Setyanto D.B., Citraresmi E., Effendi J.A., Habibah L., Octaviantie P.D., Utami I.N.A., Prawira Y., Kaswandani N., Alam A., Kadafi K.T., Pulungan A.B. |
18435202300;57200573842;57195720458;57205428706;56510252700;57191512707;57287717900;57288262700;57287718000;57224730593;15133254800;57215582843;57287718100;57203009929;57224512641;57287899600;57287899700;57287718200;57287718300;55455747000;57195941745;57201672408;57211313656;57192905981; |
Pediatric COVID-19: Report From Indonesian Pediatric Society Data Registry |
2021 |
Frontiers in Pediatrics |
9 |
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716898 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116558206&doi=10.3389%2ffped.2021.716898&partnerID=40&md5=8c294f39457ac77d477f3bb1d2dd9eb4 |
The Indonesian Pediatric Society, Jakarta, Indonesia; Department of Pediatrics, Faculty of Medicine, Cipto Mangunkusumo National Central Hospital, Universitas Indonesia, Jakarta, Indonesia; Department of Pediatrics, Faculty of Medicine, Dr. Soetomo Hospital, Universitas Airlangga, Surabaya, Indonesia; Department of Pediatrics, Faculty of Medicine, Hasan Sadikin Hospital, Universitas Padjajaran, Bandung, Indonesia; Department of Pediatrics, Faculty of Medicine, Dr. Kariadi Hospital, Universitas Diponegoro, Semarang, Indonesia; Department of Pediatrics, Harapan Kita Women and Children Hospital, Jakarta, Indonesia; Department of Pediatrics, Fatmawati Hospital, Jakarta, Indonesia; Department of Pediatrics, Faculty of Medicine, Dr. Saiful Anwar Hospital, Universitas Brawijaya, Malang, Indonesia |
Pudjiadi, A.H., The Indonesian Pediatric Society, Jakarta, Indonesia, Department of Pediatrics, Faculty of Medicine, Cipto Mangunkusumo National Central Hospital, Universitas Indonesia, Jakarta, Indonesia; Putri, N.D., The Indonesian Pediatric Society, Jakarta, Indonesia, Department of Pediatrics, Faculty of Medicine, Cipto Mangunkusumo National Central Hospital, Universitas Indonesia, Jakarta, Indonesia; Sjakti, H.A., The Indonesian Pediatric Society, Jakarta, Indonesia, Department of Pediatrics, Faculty of Medicine, Cipto Mangunkusumo National Central Hospital, Universitas Indonesia, Jakarta, Indonesia; Yanuarso, P.B., The Indonesian Pediatric Society, Jakarta, Indonesia, Department of Pediatrics, Faculty of Medicine, Cipto Mangunkusumo National Central Hospital, Universitas Indonesia, Jakarta, Indonesia; Gunardi, H., The Indonesian Pediatric Society, Jakarta, Indonesia, Department of Pediatrics, Faculty of Medicine, Cipto Mangunkusumo National Central Hospital, Universitas Indonesia, Jakarta, Indonesia; Roeslani, R.D., The Indonesian Pediatric Society, Jakarta, Indonesia, Department of Pediatrics, Faculty of Medicine, Cipto Mangunkusumo National Central Hospital, Universitas Indonesia, Jakarta, Indonesia; Pasaribu, A.D., The Indonesian Pediatric Society, Jakarta, Indonesia; Nurmalia, L.D., The Indonesian Pediatric Society, Jakarta, Indonesia; Sambo, C.M., The Indonesian Pediatric Society, Jakarta, Indonesia; Ugrasena, I.D.G., The Indonesian Pediatric Society, Jakarta, Indonesia, Department of Pediatrics, Faculty of Medicine, Dr. Soetomo Hospital, Universitas Airlangga, Surabaya, Indonesia; Soeroso, S., The Indonesian Pediatric Society, Jakarta, Indonesia; Firman, A., The Indonesian Pediatric Society, Jakarta, Indonesia, Department of Pediatrics, Faculty of Medicine, Hasan Sadikin Hospital, Universitas Padjajaran, Bandung, Indonesia; Muryawan, H., The Indonesian Pediatric Society, Jakarta, Indonesia, Department of Pediatrics, Faculty of Medicine, Dr. Kariadi Hospital, Universitas Diponegoro, Semarang, Indonesia; Setyanto, D.B., The Indonesian Pediatric Society, Jakarta, Indonesia, Department of Pediatrics, Faculty of Medicine, Cipto Mangunkusumo National Central Hospital, Universitas Indonesia, Jakarta, Indonesia; Citraresmi, E., The Indonesian Pediatric Society, Jakarta, Indonesia, Department of Pediatrics, Harapan Kita Women and Children Hospital, Jakarta, Indonesia; Effendi, J.A., The Indonesian Pediatric Society, Jakarta, Indonesia, Department of Pediatrics, Fatmawati Hospital, Jakarta, Indonesia; Habibah, L., The Indonesian Pediatric Society, Jakarta, Indonesia; Octaviantie, P.D., Department of Pediatrics, Faculty of Medicine, Cipto Mangunkusumo National Central Hospital, Universitas Indonesia, Jakarta, Indonesia; Utami, I.N.A., The Indonesian Pediatric Society, Jakarta, Indonesia; Prawira, Y., The Indonesian Pediatric Society, Jakarta, Indonesia, Department of Pediatrics, Faculty of Medicine, Cipto Mangunkusumo National Central Hospital, Universitas Indonesia, Jakarta, Indonesia; Kaswandani, N., The Indonesian Pediatric Society, Jakarta, Indonesia, Department of Pediatrics, Faculty of Medicine, Cipto Mangunkusumo National Central Hospital, Universitas Indonesia, Jakarta, Indonesia; Alam, A., The Indonesian Pediatric Society, Jakarta, Indonesia, Department of Pediatrics, Faculty of Medicine, Hasan Sadikin Hospital, Universitas Padjajaran, Bandung, Indonesia; Kadafi, K.T., The Indonesian Pediatric Society, Jakarta, Indonesia, Department of Pediatrics, Faculty of Medicine, Dr. Saiful Anwar Hospital, Universitas Brawijaya, Malang, Indonesia; Pulungan, A.B., The Indonesian Pediatric Society, Jakarta, Indonesia, Department of Pediatrics, Faculty of Medicine, Cipto Mangunkusumo National Central Hospital, Universitas Indonesia, Jakarta, Indonesia |
Background: Indonesia has a high number of COVID-19 cases and mortalities relative to not only among the Asia Pacific region but the world. Children were thought to be less affected by the virus compared to adults. Most of the public data reported combined data between adults and children. The Indonesian Pediatric Society (IPS) was involved in the COVID-19 response, especially in the area of child health. One of IPS's activities is collecting data registries from each of their chapters to provide a better understanding of COVID-19 in children. Objective: The objective of this study was to share the data of suspected and confirmed COVID-19 cases in children from IPS's COVID-19 data registry. Method: This is a retrospective study from the IPS's COVID-19 registry data. We collected the data of COVID-19 in children during March to December 2020 from each of the IPS chapters. We analyzed the prevalence, case fatality rate (CFR), age groups, diagnosis, and comorbidities of the children diagnosed with COVID-19. Result: As of December 21, 2020, there were 35,506 suspected cases of children with COVID-19. In total, there were 522 deaths, with a case fatality ratio (CFR) of 1.4. There were 37,706 confirmed cases with 175 fatalities (CFR 0.46). The highest mortality in confirmed COVID-19 cases was from children ages 10–18 years (42 out of 159 cases: 26%). The most common comorbidity and diagnosis found were malignancy (17.3%) and respiratory failure (54.5%). Conclusion: The CFR of confirmed COVID-19 cases in children in Indonesia is high and should be a major public concern. © Copyright © 2021 Pudjiadi, Putri, Sjakti, Yanuarso, Gunardi, Roeslani, Pasaribu, Nurmalia, Sambo, Ugrasena, Soeroso, Firman, Muryawan, Setyanto, Citraresmi, Effendi, Habibah, Octaviantie, Utami, Prawira, Kaswandani, Alam, Kadafi and Pulungan. |
children; comorbidities; COVID-19; Indonesia; mortality |
adolescent; adult; Article; case fatality rate; cause of death; child; comorbidity; coronavirus disease 2019; human; Indonesia; major clinical study; malignant neoplasm; medical society; mortality; pediatrics; prevalence; questionnaire; register; respiratory failure; retrospective study; sepsis; septic shock |
Frontiers Media S.A. |
22962360 |
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Article |
Q1 |
960 |
4641 |
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175 |
Tamba R.P., Moenadjat Y. |
47761736600;57190371576; |
Oral Spermine Supplementation in Gestated Rabbit: A Study on Villi Height of Immature Intestines |
2021 |
Frontiers in Surgery |
8 |
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721560 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115713070&doi=10.3389%2ffsurg.2021.721560&partnerID=40&md5=ef2b810fab926ddb3b4313b8d20045f5 |
Faculty of Medicine, Department of Surgery Cipto, Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia |
Tamba, R.P., Faculty of Medicine, Department of Surgery Cipto, Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Moenadjat, Y., Faculty of Medicine, Department of Surgery Cipto, Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia |
Introduction: Immature intestines are the major problem in prematurity. Postnatal oral spermine has been shown in studies to improve intestinal maturation in rats and piglets. This study aimed to find out the efficacy of spermine in rabbits during gestation. Method: An experimental study was done in an unblinded, randomized manner on those treated with and without spermine administration. A morphological examination of hematoxylin–eosin-stained villi was performed under a light microscope with a focus on villi height. Data were subjected to analysis. Results: The median of the spermine-treated group was found to be higher at 24, 26, and 28 days than the non-spermine group, but was not significantly different. Conclusion: Oral spermine supplementation during gestation might improve intestinal villi height in immature rabbit intestines. © Copyright © 2021 Tamba and Moenadjat. |
gestation; immature intestines; rabbit; spermine; villi height |
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Frontiers Media S.A. |
2296875X |
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Article |
Q2 |
483 |
10376 |
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176 |
Nakhaei P., Margiana R., Bokov D.O., Abdelbasset W.K., Jadidi Kouhbanani M.A., Varma R.S., Marofi F., Jarahian M., Beheshtkhoo N. |
57226413840;56685900600;56845561300;57208873763;57219274421;7201793587;57199650994;16241593900;57201547070; |
Liposomes: Structure, Biomedical Applications, and Stability Parameters With Emphasis on Cholesterol |
2021 |
Frontiers in Bioengineering and Biotechnology |
9 |
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705886 |
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4 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115653337&doi=10.3389%2ffbioe.2021.705886&partnerID=40&md5=0d6cee3ed2be3a97e6c2beb3d6c668b5 |
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Cipto Mangunkusumo Hospital, The National Referral Hospital, Central Jakarta, Indonesia; Master’s Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Institute of Pharmacy, Sechenov First Moscow State Medical University, Moscow, Russian Federation; Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology, and Food Safety, Moscow, Russian Federation; Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia; Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt; Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Czech Republic; Regional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute, Palacký University in Olomouc, Olomouc, Czech Republic; Department of Hematology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Toxicology and Chemotherapy Unit (G401), German Cancer Research Center, Heidelberg, Germany |
Nakhaei, P., School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Margiana, R., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia, Cipto Mangunkusumo Hospital, The National Referral Hospital, Central Jakarta, Indonesia, Master’s Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Bokov, D.O., Institute of Pharmacy, Sechenov First Moscow State Medical University, Moscow, Russian Federation, Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology, and Food Safety, Moscow, Russian Federation; Abdelbasset, W.K., Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia, Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt; Jadidi Kouhbanani, M.A., Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Czech Republic; Varma, R.S., Regional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute, Palacký University in Olomouc, Olomouc, Czech Republic; Marofi, F., Department of Hematology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Jarahian, M., Toxicology and Chemotherapy Unit (G401), German Cancer Research Center, Heidelberg, Germany; Beheshtkhoo, N., Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Czech Republic |
Liposomes are essentially a subtype of nanoparticles comprising a hydrophobic tail and a hydrophilic head constituting a phospholipid membrane. The spherical or multilayered spherical structures of liposomes are highly rich in lipid contents with numerous criteria for their classification, including structural features, structural parameters, and size, synthesis methods, preparation, and drug loading. Despite various liposomal applications, such as drug, vaccine/gene delivery, biosensors fabrication, diagnosis, and food products applications, their use encounters many limitations due to physico-chemical instability as their stability is vigorously affected by the constituting ingredients wherein cholesterol performs a vital role in the stability of the liposomal membrane. It has well established that cholesterol exerts its impact by controlling fluidity, permeability, membrane strength, elasticity and stiffness, transition temperature (Tm), drug retention, phospholipid packing, and plasma stability. Although the undetermined optimum amount of cholesterol for preparing a stable and controlled release vehicle has been the downside, but researchers are still focused on cholesterol as a promising material for the stability of liposomes necessitating explanation for the stability promotion of liposomes. Herein, the prior art pertaining to the liposomal appliances, especially for drug delivery in cancer therapy, and their stability emphasizing the roles of cholesterol. © Copyright © 2021 Nakhaei, Margiana, Bokov, Abdelbasset, Jadidi Kouhbanani, Varma, Marofi, Jarahian and Beheshtkhoo. |
cholesterol; compounds; lipids; liposome; stability |
Automobile manufacture; Chemical stability; Controlled drug delivery; Food products; Liposomes; Medical applications; Phospholipids; Plasma stability; Targeted drug delivery; Application parameters; Biomedical applications; Compound; Hydrophilic heads; Hydrophobic tails; Liposome structures; Multi-layered; Phospholipid membrane; Spherical structures; Stability parameters; Cholesterol |
Frontiers Media S.A. |
22964185 |
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Review |
Q1 |
1081 |
3891 |
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222 |
Sirait B., Wiweko B., Jusuf A.A., Iftitah D., Muharam R. |
57222720264;43061741400;57192275719;57195199068;57191492732; |
Oocyte Competence Biomarkers Associated With Oocyte Maturation: A Review |
2021 |
Frontiers in Cell and Developmental Biology |
9 |
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710292 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114781833&doi=10.3389%2ffcell.2021.710292&partnerID=40&md5=0430c11851bd72e4085a2092ee2bfda4 |
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Kristen Indonesia, Jakarta, Indonesia; Morula IVF Jakarta Clinic, Jakarta, Indonesia; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yasmin IVF Clinic, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Human Reproductive, Infertility, and Family Planning Research Cluster, Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Sirait, B., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Kristen Indonesia, Jakarta, Indonesia, Morula IVF Jakarta Clinic, Jakarta, Indonesia; Wiweko, B., Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Yasmin IVF Clinic, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Reproductive, Infertility, and Family Planning Research Cluster, Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Jusuf, A.A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Iftitah, D., Human Reproductive, Infertility, and Family Planning Research Cluster, Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Muharam, R., Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Yasmin IVF Clinic, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Reproductive, Infertility, and Family Planning Research Cluster, Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Oocyte developmental competence is one of the determining factors that influence the outcomes of an IVF cycle regarding the ability of a female gamete to reach maturation, be fertilized, and uphold an embryonic development up until the blastocyst stage. The current approach of assessing the competency of an oocyte is confined to an ambiguous and subjective oocyte morphological evaluation. Over the years, a myriad of biomarkers in the cumulus-oocyte-complex has been identified that could potentially function as molecular predictors for IVF program prognosis. This review aims to describe the predictive significance of several cumulus-oocyte complex (COC) biomarkers in evaluating oocyte developmental competence. A total of eight acclaimed cumulus biomarkers are examined in the study. RT-PCR and microarray analysis were extensively used to assess the significance of these biomarkers in foreseeing oocyte developmental competence. Notably, these biomarkers regulate vital processes associated with oocyte maturation and were found to be differentially expressed in COC encapsulating oocytes of different maturity. The biomarkers were reviewed according to the respective oocyte maturation events namely: nuclear maturation, apoptosis, and extracellular matrix remodeling, and steroid metabolism. Although substantial in vitro evidence was presented to justify the potential use of cumulus biomarkers in predicting oocyte competency and IVF outcomes, the feasibility of assessing these biomarkers as an add-on prognostic procedure in IVF is still restricted due to study challenges. © Copyright © 2021 Sirait, Wiweko, Jusuf, Iftitah and Muharam. |
biomarker; cumulus-oocyte complex (COC); in-vitro fertilization; oocyte competence; oocyte maturation |
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Frontiers Media S.A. |
2296634X |
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946 |
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223 |
Razeghian E., Margiana R., Chupradit S., Bokov D.O., Abdelbasset W.K., Marofi F., Shariatzadeh S., Tosan F., Jarahian M. |
57223052224;56685900600;57211329338;56845561300;57208873763;57199650994;57225946579;57216155951;16241593900; |
Mesenchymal Stem/Stromal Cells as a Vehicle for Cytokine Delivery: An Emerging Approach for Tumor Immunotherapy |
2021 |
Frontiers in Medicine |
8 |
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721174 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114747651&doi=10.3389%2ffmed.2021.721174&partnerID=40&md5=eb488365f37edbafb0ec0a51d29dbfc9 |
Human Genetics Division, Medical Biotechnology Department, National Institute of Genetics Engineering and Biotechnology (NIGEB), Tehran, Iran; Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Cipto Mangunkusumo Hospital, The National Referral Hospital, Central Jakarta, Indonesia; Master's Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Occupational Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand; Institute of Pharmacy, Sechenov First Moscow State Medical University, Moscow, Russian Federation; Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation; Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia; Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt; Immunology Research Center (IRC), Tabriz University of Medical Sciences, Tabriz, Iran; Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Student Research Committee, Semnan University of Medical Sciences, Semnan, Iran; Toxicology and Chemotherapy Unit (G401), German Cancer Research Center, Heidelberg, Germany |
Razeghian, E., Human Genetics Division, Medical Biotechnology Department, National Institute of Genetics Engineering and Biotechnology (NIGEB), Tehran, Iran; Margiana, R., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Cipto Mangunkusumo Hospital, The National Referral Hospital, Central Jakarta, Indonesia, Master's Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Chupradit, S., Department of Occupational Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand; Bokov, D.O., Institute of Pharmacy, Sechenov First Moscow State Medical University, Moscow, Russian Federation, Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation; Abdelbasset, W.K., Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia, Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt; Marofi, F., Immunology Research Center (IRC), Tabriz University of Medical Sciences, Tabriz, Iran; Shariatzadeh, S., Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Tosan, F., Student Research Committee, Semnan University of Medical Sciences, Semnan, Iran; Jarahian, M., Toxicology and Chemotherapy Unit (G401), German Cancer Research Center, Heidelberg, Germany |
Pro-inflammatory cytokines can effectively be used for tumor immunotherapy, affecting every step of the tumor immunity cycle. Thereby, they can restore antigen priming, improve the effector immune cell frequencies in the tumor microenvironment (TME), and eventually strengthen their cytolytic function. A renewed interest in the anticancer competencies of cytokines has resulted in a substantial promotion in the number of trials to address the safety and efficacy of cytokine-based therapeutic options. However, low response rate along with the high toxicity associated with high-dose cytokine for reaching desired therapeutic outcomes negatively affect their clinical utility. Recently, mesenchymal stem/stromal cells (MSCs) due to their pronounced tropism to tumors and also lower immunogenicity have become a promising vehicle for cytokine delivery for human malignancies. MSC-based delivery of the cytokine can lead to the more effective immune cell-induced antitumor response and provide sustained release of target cytokines, as widely evidenced in a myriad of xenograft models. In the current review, we offer a summary of the novel trends in cytokine immunotherapy using MSCs as a potent and encouraging carrier for antitumor cytokines, focusing on the last two decades' animal reports. © Copyright © 2021 Razeghian, Margiana, Chupradit, Bokov, Abdelbasset, Marofi, Shariatzadeh, Tosan and Jarahian. |
cytokine; cytokine delivery; gene therapy; mesenchymal stem/stromal cells; tumor-immunotherapy |
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Frontiers Media S.A. |
2296858X |
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Review |
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1388 |
2608 |
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227 |
Hamid A.R.A.H., Luna-Velez M.V., Dudek A.M., Jansen C.F.J., Smit F., Aalders T.W., Verhaegh G.W., Schaafsma E., Sedelaar J.P.M., Schalken J.A. |
57202054669;56667692600;48761226600;8515960200;7005490663;6603571474;6603760728;6603552898;6602103585;7101847178; |
Molecular Phenotyping of AR Signaling for Predicting Targeted Therapy in Castration Resistant Prostate Cancer |
2021 |
Frontiers in Oncology |
11 |
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721659 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114356605&doi=10.3389%2ffonc.2021.721659&partnerID=40&md5=cd27bd052cb98d77c92f1b93868f2c4f |
Department of Urology, Radboud University Medical Center, Nijmegen, Netherlands; Department of Urology, Ciptomangunkusumo Hospital, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; NovioGendix, Nijmegen, Netherlands; Department of Pathology, Radboud University Medical Center, Nijmegen, Netherlands |
Hamid, A.R.A.H., Department of Urology, Radboud University Medical Center, Nijmegen, Netherlands, Department of Urology, Ciptomangunkusumo Hospital, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Luna-Velez, M.V., Department of Urology, Radboud University Medical Center, Nijmegen, Netherlands; Dudek, A.M., Department of Urology, Radboud University Medical Center, Nijmegen, Netherlands; Jansen, C.F.J., Department of Urology, Radboud University Medical Center, Nijmegen, Netherlands; Smit, F., NovioGendix, Nijmegen, Netherlands; Aalders, T.W., Department of Urology, Radboud University Medical Center, Nijmegen, Netherlands; Verhaegh, G.W., Department of Urology, Radboud University Medical Center, Nijmegen, Netherlands; Schaafsma, E., Department of Pathology, Radboud University Medical Center, Nijmegen, Netherlands; Sedelaar, J.P.M., Department of Urology, Radboud University Medical Center, Nijmegen, Netherlands; Schalken, J.A., Department of Urology, Radboud University Medical Center, Nijmegen, Netherlands |
Castration-resistant prostate cancer (CRPC) is defined by resistance of the tumor to androgen deprivation therapy (ADT). Several molecular changes, particularly in the AR signaling cascade, have been described that may explain ADT resistance. The variety of changes may also explain why the response to novel therapies varies between patients. Testing the specific molecular changes may be a major step towards personalized treatment of CRPC patients. The aim of our study was to evaluate the molecular changes in the AR signaling cascade in CRPC patients. We have developed and validated several methods which are easy to use, and require little tissue material, for exploring AR signaling pathway changes simultaneously. We found that the AR signaling pathway is still active in the majority of our CRPC patients, due to molecular changes in AR signaling components. There was heterogeneity in the molecular changes observed, but we could classify the patients into 4 major subgroups which are: AR mutation, AR amplification, active intratumoral steroidogenesis, and combination of AR amplification and active intratumoral steroidogenesis. We suggest characterizing the AR signaling pathway in CRPC patients before beginning any new treatment, and a recent fresh tissue sample from the prostate or a metastatic site should be obtained for the purpose of this characterization. © Copyright © 2021 Hamid, Luna-Velez, Dudek, Jansen, Smit, Aalders, Verhaegh, Schaafsma, Sedelaar and Schalken. |
androgen receptor; castration-resistant prostate cancer; gene amplification; gene mutation; splice variant; steroidogenic enzymes |
aldo keto reductase family 1 member C3; androgen receptor; antiandrogen; estrogen; genomic DNA; gonadorelin agonist; Article; castration resistant prostate cancer; cell culture; controlled study; gene amplification; gene expression; gene mutation; human; human tissue; immunohistochemistry; male; molecularly targeted therapy; mRNA expression level; orchiectomy; phenotype; prostate hypertrophy; real time polymerase chain reaction; RNA extraction; signal transduction |
Frontiers Media S.A. |
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1834 |
1574 |
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Reksodiputro M.H., Harahap A.R., Setiawan L., Yosia M. |
35090488800;6507325543;57053036100;57204933098; |
A Modified Preparation Method of Ideal Platelet-Rich Fibrin Matrix From Whole Blood |
2021 |
Frontiers in Medicine |
8 |
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724488 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114628863&doi=10.3389%2ffmed.2021.724488&partnerID=40&md5=2a784dc8d442d97efac9d34d1c6769cc |
Division of Facial Plastic & Reconstructive Surgery, Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Clinical Pathology, Rumah Sakit Dharmais Pusat Kanker Nasional, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Reksodiputro, M.H., Division of Facial Plastic & Reconstructive Surgery, Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Harahap, A.R., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Setiawan, L., Department of Clinical Pathology, Rumah Sakit Dharmais Pusat Kanker Nasional, Jakarta, Indonesia; Yosia, M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
One bioproduct that is widely used in the wound healing process is platelet-rich plasma (PRP). PRP is a liquid solution with high autologous platelet concentration, making it a good source of growth factors to accelerate wound healing. Recent development in PRP had created a new product called platelet-rich fibrin matrix (PRFM), which has a denser and more flexible structure. PRFM is the newest generation of platelet concentrate with a fibrin matrix that holds platelet in it. The key concept in creating PRFM from PRP is the addition of CaCl2 followed by centrifugation, which converts fibrinogen to fibrin, and the fibrin cross-links to form a matrix that contains viable platelets. There are many commercially available kits to create PRFM, but they are often expensive and uneconomical. This research will test a modified method of making ideal PRFM from PRP without any commercial kits. The modified method will include determining the minimum level of CaCl2 used, the type of centrifuge, and the speed and duration of centrifugation. By performing a modified preparation method on five samples of whole blood, it was found that the ideal PRFM could be made by mixing PRP with 25 mM CaCl2 and centrifuging it at a speed of 2,264 × g for 25 min at room temperature. The PRP and PRFM platelet counts of this method tend to be lower than the platelet counts found in other studies. Although visually comparable, further study is needed to compare the performance of PRFMs made with this method and PRFMs made with commercial kits. © Copyright © 2021 Reksodiputro, Harahap, Setiawan and Yosia. |
CaCl2; centrifugation; fibrin matrix; platelet concentrate; platelet rich fibrin matrix; platelet rich plasma |
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Frontiers Media S.A. |
2296858X |
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Article |
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1388 |
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Farhoudian A., Radfar S.R., Ardabili H.M., Rafei P., Ebrahimi M., Zonoozi A.K., De Jong C.A.J., Vahidi M., Yunesian M., Kouimtsidis C., Arunogiri S., Hansen H., Brady K.T., Potenza M.N., Baldacchino A.M., Ekhtiari H., Abagiu A.O., Abouna F.D.N., Ahmed M.H., Al-Ansari B., Al-Khair F.M.A., Almaqbali M.H., Ambekar A., Arya S., Asebikan V.O., Ayasreh M.A., Basu D., Benmebarek Z., Bhad R., Blaise M., Bonnet N., Brasch J., Broers B., Busse A., Butner J.L., Camilleri M., Campello G., Carra G., Celic I., Chalabianloo F., Chaturvedi A., Cherpitel J.J.E.N., Clark K.J., Cyders M.A., de Bernardis E., Deilamizade A., Derry J.E., Dhagudu N.K., Dolezalova P., Dom G., Dunlop A.J., Elhabiby M.M., Elkholy H., Essien N.F., Farah G.I., Ferri M., Floros G.D., Friedman C., Fuderanan C.H., Gerra G., Ghosh A., Gogia M., Grammatikopoulos I.A., Grandinetti P., Guirguis A., Gutnisky D., Haber P.S., Hassani-Abharian P., Hooshyari Z., Ibrahim I.I.M., Ieong H.F.-H., Indradewi R.N., Iskandar S., Isra T.N., Jain S., James S., Javadi S.M.H., Joe K.H., Jokubonis D., Jovanova A.T., Kamal R.M., Kantchelov A.I., Kathiresan P., Katzman G., Kawale P., Kern A.M., Kessler F.H.P., Kim S.-G.S., Kimball A.M., Kljucevic Z., Kurniasanti K.S., Lev R., Lee H.K., Lengvenyte A., Lev-Ran S., Mabelya G.S., Mahi M.A.E., Maphisa J.M., Maremmani I., Masferrer L., Massah O., McCambridge O., McGovern G.G., Min A.K., Moghanibashi-Mansourieh A., Mora-Rios J., Mudalige I.U.K., Mukherjee D., Munira P.M., Myers B., Menon T. N. J., Narasimha V.L., Ndionuka N., Nejatisafa A.-A., Niaz K., Nizami A.T., Nuijens J.H., Orsolini L., Oum V., Oyemade A.A., Palavra I.R., Pant S.B., Paredes J., Peyron E., Quirós R.A., Qurishi R., Rafiq N.U.Z., Raghavendra Rao R., Ratta-Apha W., Raymond K.-L., Reimer J., Renaldo E., Rezapour T., Robertson J.R., Roncero C., Roub F., Rubenstein E.J., Rupp C.I., Saenz E., Salehi M., Samartzis L., Sarubbo L.B., Segrec N., Shah B., Shen H., Shirasaka T., Shoptaw S., Sintango F.M., Sosa V.A., Subata E., Sztycberg N., Taghizadeh F., Wee Teck J.B.T., Tjagvad C., Torrens M., Twala J.M., Vadivel R., Volpicelli J.R., Weijs J., Wintoniw S.M., Wittayanookulluk A., Wojnar M., Yasir S., Yitayih Y., Zhao M., ISAM Global Survey Consortium (ISAM-GSC) |
25631625900;36019651400;55658200400;57218199674;57218203004;57218205554;55394697400;57203060812;14622058700;6602323007;55912287400;57221996850;7101818468;7006591634;6603786612;26632924600;55021572500;57221605725;57221411272;56996118200;55549232500;57221411355;35749590300;35463222300;57221410006;57221410448;18833291700;57219202850;55789741800;6603894892;15135243700;57189041459;7003868723;57196510693;56816710600;57221410155;56400851700;7003818736;24176502200;26026739900;54936844000;57358665500;57221410761;6504408224;55604104700;56059025100;57221409824;57203836122;6603422138;12768470700;57219674374;26767656700;55086535500;57191041815;57221411550;8871569800;12768168000;57221411410;57210375852;55578764500;36833820900;57205763778;27367905800;55487378900;55496109900;57221411047;7004422180;54892046900;36607951600;57216708013;57193806115;57221410095;37004580200;57221604184;57207211289;57216621884;57207842636;15062725000;57188646762;57221411023;36996943600;24468101500;57023935300;57221410517;55928375400;55031071400;57202970264;57221410531;35420584800;57203155640;57209262171;8913859800;8600274900;57189340754;23019092700;57221410613;57223919852;57200792839;7003948428;6507438528;57044778200;56527137000;57221410507;57221411329;56059054800;6506077151;57214574855;57197364393;57221410358;7202684194;57200567557;56272241600;57221410263;55666521300;57194102646;12144358600;7004198198;55376767200;57217227990;16234058300;57225265059;36114863900;57221411223;57205355338;57221409971;55735687800;57221410341;57358663600;35604346900;56783754400;56000939600;57221410809;56968163500;57205640157;7003524112;57191926633;57221411128;7006106435;26656074800;57226311750;36633076300;57221409908;24476669600;57219874143;57216762422;7005625709;7003465287;57221409902;57221409982;56616079200;57221410011;55802145800;57221409677;57188537200;7006681890;57221411350;57219874702;57209053124;57221410085;57221410695;55151590700;6701757799;57221410275;57204013732;55185317400; |
A Global Survey on Changes in the Supply, Price, and Use of Illicit Drugs and Alcohol, and Related Complications During the 2020 COVID-19 Pandemic |
2021 |
Frontiers in Psychiatry |
12 |
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646206 |
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6 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113236018&doi=10.3389%2ffpsyt.2021.646206&partnerID=40&md5=583fc4953970f4d964584bcd9a7d5b02 |
Department of Psychiatry, Tehran University of Medical Sciences, Tehran, Iran; Department of Neuroscience and Addiction, School of Advanced Technologies in Medicine (SATiM), Tehran University of Medical Sciences, Tehran, Iran; Integrated Substance Abuse Programs Department, University of California, Los Angeles, Los Angeles, CA, United States; Psychiatry and Behavioral Sciences Research Center, Faculty of Medicine, Ibn-e-Sina Hospital, Mashhad University of Medical Sciences, Mashhad, Iran; Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Psychology, Faculty of Psychology and Education, University of Tehran, Tehran, Iran; Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran; Behavioral Science Institute, Radboud University, Nijmegen, Netherlands; School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Surrey and Borders Partnership National Health Service Foundation Trust, Leatherhead, United Kingdom; Turning Point, Eastern Health, Box Hill, VIC, Australia; Departments of Anthropology and Psychiatry, New York University, New York, NY, United States; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States; Yale School of Medicine, Connecticut Council on Problem Gambling and Connecticut Mental Health Center, New Haven, CT, United States; Division of Population and Behavior Sciences, Medical School, University of St Andrews, St Andrews, United Kingdom; Laureate Institute for Brain Research, Tulsa, OK, United States; National Institute for Infectious Diseases, Prof. Dr. Matei Bals-Arena OMT Department, Romania; Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Cameroon; Alamal psychiatric hospital, Dubai, United Arab Emirates; Sydney Medical School, University of SydneyNSW, Australia; Al Ahliyya Amman University, Amman, Jordan; Ministry of Health, Muscat, Oman; Department of Psychiatry and National Drug Dependence Treatment Centre (NDDTC), All India Institute of Medical Sciences (AIIMS), New Delhi, India; State Drug Dependence Treatment Centre, Institute of Mental Health, Pt BDS University of Health Sciences, India; Department of Psychiatry, College of Medicine, University of Ibadan, Nigeria; Addiction Medicine Clinic, Jordan; Drug De-addiction and Treatment Centre, Department of Psychiatry, Postgraduate Institute of Medical Education & Research, Chandigarh, India; Addiction Medicine Clinic, Mila, Algeria; Centre medical Marmottan, France; Réseau de Prévention des Addictions (RESPADD), France; Department of Psychiatry and Behavioural Neurosciences, Michael DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada; Geneva University Hospitals, Switzerland; United Nations Office on Drugs and Crime (UNODC), Vienna, Austria; CUNY School of Medicine, New York, United States; Agenzija Sedqa, Malta; Department of Medicine and Surgery, University Milan-Bicocca, Italy; University Psychiatric Hospital Vrapce-Zagreb, Croatia; Department of Addiction Medicine, Haukeland University Hospital, Bergen, Norway; Department of Biochemistry, Melaka Manipal Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India; Addiction Medicine Clinic, Mexico; Addiction Crisis Solutions, United States; Department of Psychology, Indiana University Purdue University-Indianapolis, United States; SerT Lentini, ASP Siracusa, Italy; Rebirth Charity Society NGO, Tehran, Iran; Serenity Vista Addiction Treatment Center, Panama; Department of Psychiatry, ESIC Medical College, Hyderabad, Telangana, India; National Institute of Mental Health, Czech Republic; Collaborative Antwerp Psychiatric Research Institute (CAPRI), Antwerp University (UA), Belgium; Drug & Alcohol Clinical Services, Hunter New England Local Health District, Australia; Ain Shams University, Cairo, Egypt; Department of Neurology and Psychiatry, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Centre for Research and Information on Substance Abuse, Nigeria; Addiction Medicine Clinic, Syrian Arab Republic; European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), Italy; Department of Psychiatry, Aristotle University of Thessaloniki, Greece; Brown University and Lifespan Health System, Providence, RI, United States; Fuderanan Mental Health Clinic, Philippines; Drug De-addiction & Treatment Centre, Department of Psychiatry, Postgraduate Institute of Medical Education & Research, Chandigarh, India; Georgian Harm Reduction Network, Georgia; Organization Against Drugs, Primary Care Health Center, Veria, Greece; Addictions Services (Ser.D.), Department of Territorial Services, ASL Teramo, Italy; Swansea University Medical School, Institute of Life Sciences 2, Singleton CampusSA2 8PP, United Kingdom; Universidad de Buenos Aires, Argentina; University of Sydney, Australia; Institutes for Cognitive Science Studies (IRICSS), Brain and Cognition Clinic, Tehran, Iran; Tehran University of Medical Sciences, Tehran, Iran; Department of Anesthesiology, Yale University, United States; Drugs Rehabilitation Center, National Narcotics Board of Indonesia, Indonesia; Department of Psychiatry, Universitas Padjadjaran, Bandung, West Java, Indonesia; National Institute of Education, Sri Lanka; Department of Psychiatry, Heritage Institute of Medical Sciences (HIMS), Varanasi, India; Univeristi Malaysia Sabah, Malaysia; Department of Social Work, University of Social Welfare & Rehabilitation Sciences, Tehran, Iran; National Center for Mental Health of Korea, South Korea; Republican Center for Addictive Disorders, Lithuania; Addiction Medicine Clinic, North Macedonia; Naufar Institute, Doha, Qatar; The Kantchelov Clinic, Sofia, Bulgaria; Mount Sinai Medical Center, New York, United States; African Institute for Development Policy, Malawi; Sobriety Centers of New Hampshire, United States; Federal University of Rio Grande do Sul, Brazil; Pusan National University Yangsan Hospital, Department of Neuropsychiatry, Yangsan, South Korea; Chatham House, United States; Institute for Public Health of Split-Dalmatia County, Croatia; Faculty of Medicine, Universitas Indonesia-Ciptomangunkusumo Hospital, Indonesia; Scripps Mercy Hospital, San Diego, United States; Department of Psychiatry, The Catholic University of Korea, Seoul, South Korea; Faculty of Medicine, Institute of Clinical Medicine, Psychiatric Clinic, Vilnius University, Vilnius, Lithuania; Israel Center on Addiction, Netanya, Israel; Community Health Work, Tanzania; Hayat Center for Treatment and Psycho-social Rehabilitation, Khartoum, Sudan; University of Botswana, Botswana; V.P. Dole, Dual Disorder Unit, Santa Chiara University Hospital, University of Pisa, Italy; CAS Girona, Department of Psychology, University of Girona, Spain; Substance Abuse and Dependence Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran; Community addiction team, Southern Health and Social Care Trust, United Kingdom; Priority Medical Clinic, Dublin, Ireland; Save the Children International Organization, Burma; Dirección de Investigaciones Epidemiológicas y Sociales, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, United States; Department of Psychiatry, Faculty of Medicine, Sir John Kotelawala Defence University, Sri Lanka; Centre for Addiction Medicine, NIMHANS, Bangalore, India; Kleopatra Kodric, Irena Nisic, Slovenia; Alcohol Tobacco and Other Drug Research Unit, South African Medical Research Council, South Africa; NIMHANS, Bangalore, India; Centre for Addiction Medicine, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, India; Federal Neuropsychiatric Hospital, Calabar, Nigeria; Department of Psychiatry, Psychosomatic Research Center, Tehran University of Medical Sciences, Tehran, Iran; Institute of Psychiatry, WHO Collaborating Center for Mental Health, Pakistan; Brijder Addiction Care, Zaandam, Netherlands; Department of Clinical Neurosciences/DIMSC, School of Medicine, Polytechnic University of Marche, Ancona, Italy; Koh Kong Provincial Hospital, Cambodia; Kaiser Permanente, United States; Psychiatric hospital Sveti Ivan, Zagreb, Croatia; Department of Psychiatry and mental health, Institute of Medicine, Tribhuvan University, Nepal; Universidad de El Salvador, El Salvador; AddiPsy, Lyon, France; Addiction Medicine Clinic, Costa Rica; Novadic-Kentron Addiction Care Network, Vught, Netherlands; Phoenix Foundation for Research and Development, Pakistan; Barwon Health, Geelong, Australia; Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand; University of the Sunshine Coast (USC)QLD, Australia; Center for Interdisciplinary Addiction Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Drugs Rehabilitation Center, National Narcotics Board of Indonesia; Department of Cognitive Psychology, Institute for Cognitive Science Studies, Tehran, Iran; Usher Institute, University of Edinburgh, United Kingdom; Psychiatry Service, University of Salamanca Health Care Complex, Salamanca, Spain; PGIMER, Chandigarh, India; Street Health Centre, Canada; Department of Psychiatry, Psychotherapy, and Psychosomatics, Medical University Innsbruck, Austria; Department of Neurosciences and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; Medical School, University of Cyprus, Cyprus; Clínica Psiquiátrica de la Facultad de Medicina, Uruguay; Center for Treatment of Drug addiction, University Psychiatric Clinic, Ljubljana, Slovenia; Department of Psychiatry, Patan Academy of Health Sciences, School of Medicine, Lagankhel, Nepal; Department of Psychiatry, Second Xiangya Hospital, Central South University, China; Department of Psychiatry, Teine Keijinkai Medical Center, Japan; David Geffen School of Medicine at UCLA, Department of Family Medicine, United States; Health Professions Councils of Namibia, Namibia; Addiction Medicine Clinic, Uruguay; Asociasion Programa Andres Argentina, Argentina; Mazandaran University of Medical Sciences, Mazandaran, Iran; MRC/CSO SPHSU, University of Glasgow, United Kingdom; Gladsaxe Substance Use Disorder Treatment Centre, Denmark; Institut de Neuropsiquiatria i Addiccions, IMIM-Hospital del Mar, Medical Research, Barcelona, Spain; NACADA, Kenya; Waikato District Health Board (WDHB, Hamilton, New Zealand; Institute of Addiction Medicine, United States; Jellinek, Amsterdam, Netherlands; Addictions Foundation of Manitoba, Canada; Thanyarak Chiangmai Hospital, Thailand; Medical University of Warsaw, Warsaw, Poland; Jimma University, Ethiopia; Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, China |
Farhoudian, A., Department of Psychiatry, Tehran University of Medical Sciences, Tehran, Iran; Radfar, S.R., Department of Neuroscience and Addiction, School of Advanced Technologies in Medicine (SATiM), Tehran University of Medical Sciences, Tehran, Iran, Integrated Substance Abuse Programs Department, University of California, Los Angeles, Los Angeles, CA, United States; Ardabili, H.M., Psychiatry and Behavioral Sciences Research Center, Faculty of Medicine, Ibn-e-Sina Hospital, Mashhad University of Medical Sciences, Mashhad, Iran, Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Rafei, P., Department of Psychology, Faculty of Psychology and Education, University of Tehran, Tehran, Iran, Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran; Ebrahimi, M., Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran; Zonoozi, A.K., Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; De Jong, C.A.J., Behavioral Science Institute, Radboud University, Nijmegen, Netherlands; Vahidi, M., Department of Psychiatry, Tehran University of Medical Sciences, Tehran, Iran; Yunesian, M., School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Kouimtsidis, C., Surrey and Borders Partnership National Health Service Foundation Trust, Leatherhead, United Kingdom; Arunogiri, S., Turning Point, Eastern Health, Box Hill, VIC, Australia; Hansen, H., Departments of Anthropology and Psychiatry, New York University, New York, NY, United States; Brady, K.T., Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States; Potenza, M.N., Yale School of Medicine, Connecticut Council on Problem Gambling and Connecticut Mental Health Center, New Haven, CT, United States; Baldacchino, A.M., Division of Population and Behavior Sciences, Medical School, University of St Andrews, St Andrews, United Kingdom; Ekhtiari, H., Laureate Institute for Brain Research, Tulsa, OK, United States; Abagiu, A.O., National Institute for Infectious Diseases, Prof. Dr. Matei Bals-Arena OMT Department, Romania; Abouna, F.D.N., Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Cameroon; Ahmed, M.H., Alamal psychiatric hospital, Dubai, United Arab Emirates; Al-Ansari, B., Sydney Medical School, University of SydneyNSW, Australia; Al-Khair, F.M.A., Al Ahliyya Amman University, Amman, Jordan; Almaqbali, M.H., Ministry of Health, Muscat, Oman; Ambekar, A., Department of Psychiatry and National Drug Dependence Treatment Centre (NDDTC), All India Institute of Medical Sciences (AIIMS), New Delhi, India; Arya, S., State Drug Dependence Treatment Centre, Institute of Mental Health, Pt BDS University of Health Sciences, India; Asebikan, V.O., Department of Psychiatry, College of Medicine, University of Ibadan, Nigeria; Ayasreh, M.A., Addiction Medicine Clinic, Jordan; Basu, D., Drug De-addiction and Treatment Centre, Department of Psychiatry, Postgraduate Institute of Medical Education & Research, Chandigarh, India; Benmebarek, Z., Addiction Medicine Clinic, Mila, Algeria; Bhad, R., Department of Psychiatry and National Drug Dependence Treatment Centre (NDDTC), All India Institute of Medical Sciences (AIIMS), New Delhi, India; Blaise, M., Centre medical Marmottan, France; Bonnet, N., Réseau de Prévention des Addictions (RESPADD), France; Brasch, J., Department of Psychiatry and Behavioural Neurosciences, Michael DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada; Broers, B., Geneva University Hospitals, Switzerland; Busse, A., United Nations Office on Drugs and Crime (UNODC), Vienna, Austria; Butner, J.L., CUNY School of Medicine, New York, United States; Camilleri, M., Agenzija Sedqa, Malta; Campello, G., United Nations Office on Drugs and Crime (UNODC), Vienna, Austria; Carra, G., Department of Medicine and Surgery, University Milan-Bicocca, Italy; Celic, I., University Psychiatric Hospital Vrapce-Zagreb, Croatia; Chalabianloo, F., Department of Addiction Medicine, Haukeland University Hospital, Bergen, Norway; Chaturvedi, A., Department of Biochemistry, Melaka Manipal Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India; Cherpitel, J.J.E.N., Addiction Medicine Clinic, Mexico; Clark, K.J., Addiction Crisis Solutions, United States; Cyders, M.A., Department of Psychology, Indiana University Purdue University-Indianapolis, United States; de Bernardis, E., SerT Lentini, ASP Siracusa, Italy; Deilamizade, A., Rebirth Charity Society NGO, Tehran, Iran; Derry, J.E., Serenity Vista Addiction Treatment Center, Panama; Dhagudu, N.K., Department of Psychiatry, ESIC Medical College, Hyderabad, Telangana, India; Dolezalova, P., National Institute of Mental Health, Czech Republic; Dom, G., Collaborative Antwerp Psychiatric Research Institute (CAPRI), Antwerp University (UA), Belgium; Dunlop, A.J., Drug & Alcohol Clinical Services, Hunter New England Local Health District, Australia; Elhabiby, M.M., Ain Shams University, Cairo, Egypt; Elkholy, H., Department of Neurology and Psychiatry, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Essien, N.F., Centre for Research and Information on Substance Abuse, Nigeria; Farah, G.I., Addiction Medicine Clinic, Syrian Arab Republic; Ferri, M., European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), Italy; Floros, G.D., Department of Psychiatry, Aristotle University of Thessaloniki, Greece; Friedman, C., Brown University and Lifespan Health System, Providence, RI, United States; Fuderanan, C.H., Fuderanan Mental Health Clinic, Philippines; Gerra, G., United Nations Office on Drugs and Crime (UNODC), Vienna, Austria; Ghosh, A., Drug De-addiction & Treatment Centre, Department of Psychiatry, Postgraduate Institute of Medical Education & Research, Chandigarh, India; Gogia, M., Georgian Harm Reduction Network, Georgia; Grammatikopoulos, I.A., Organization Against Drugs, Primary Care Health Center, Veria, Greece; Grandinetti, P., Addictions Services (Ser.D.), Department of Territorial Services, ASL Teramo, Italy; Guirguis, A., Swansea University Medical School, Institute of Life Sciences 2, Singleton CampusSA2 8PP, United Kingdom; Gutnisky, D., Universidad de Buenos Aires, Argentina; Haber, P.S., University of Sydney, Australia; Hassani-Abharian, P., Institutes for Cognitive Science Studies (IRICSS), Brain and Cognition Clinic, Tehran, Iran; Hooshyari, Z., Tehran University of Medical Sciences, Tehran, Iran; Ibrahim, I.I.M., Ain Shams University, Cairo, Egypt; Ieong, H.F.-H., Department of Anesthesiology, Yale University, United States; Indradewi, R.N., Drugs Rehabilitation Center, National Narcotics Board of Indonesia, Indonesia; Iskandar, S., Department of Psychiatry, Universitas Padjadjaran, Bandung, West Java, Indonesia; Isra, T.N., National Institute of Education, Sri Lanka; Jain, S., Department of Psychiatry, Heritage Institute of Medical Sciences (HIMS), Varanasi, India; James, S., Univeristi Malaysia Sabah, Malaysia; Javadi, S.M.H., Department of Social Work, University of Social Welfare & Rehabilitation Sciences, Tehran, Iran; Joe, K.H., National Center for Mental Health of Korea, South Korea; Jokubonis, D., Republican Center for Addictive Disorders, Lithuania; Jovanova, A.T., Addiction Medicine Clinic, North Macedonia; Kamal, R.M., Naufar Institute, Doha, Qatar; Kantchelov, A.I., The Kantchelov Clinic, Sofia, Bulgaria; Kathiresan, P., Department of Psychiatry and National Drug Dependence Treatment Centre (NDDTC), All India Institute of Medical Sciences (AIIMS), New Delhi, India; Katzman, G., Mount Sinai Medical Center, New York, United States; Kawale, P., African Institute for Development Policy, Malawi; Kern, A.M., Sobriety Centers of New Hampshire, United States; Kessler, F.H.P., Federal University of Rio Grande do Sul, Brazil; Kim, S.-G.S., Pusan National University Yangsan Hospital, Department of Neuropsychiatry, Yangsan, South Korea; Kimball, A.M., Chatham House, United States; Kljucevic, Z., Institute for Public Health of Split-Dalmatia County, Croatia; Kurniasanti, K.S., Faculty of Medicine, Universitas Indonesia-Ciptomangunkusumo Hospital, Indonesia; Lev, R., Scripps Mercy Hospital, San Diego, United States; Lee, H.K., Department of Psychiatry, The Catholic University of Korea, Seoul, South Korea; Lengvenyte, A., Faculty of Medicine, Institute of Clinical Medicine, Psychiatric Clinic, Vilnius University, Vilnius, Lithuania; Lev-Ran, S., Israel Center on Addiction, Netanya, Israel; Mabelya, G.S., Community Health Work, Tanzania; Mahi, M.A.E., Hayat Center for Treatment and Psycho-social Rehabilitation, Khartoum, Sudan; Maphisa, J.M., University of Botswana, Botswana; Maremmani, I., V.P. Dole, Dual Disorder Unit, Santa Chiara University Hospital, University of Pisa, Italy; Masferrer, L., CAS Girona, Department of Psychology, University of Girona, Spain; Massah, O., Substance Abuse and Dependence Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran; McCambridge, O., Community addiction team, Southern Health and Social Care Trust, United Kingdom; McGovern, G.G., Priority Medical Clinic, Dublin, Ireland; Min, A.K., Save the Children International Organization, Burma; Moghanibashi-Mansourieh, A., Department of Social Work, University of Social Welfare & Rehabilitation Sciences, Tehran, Iran; Mora-Rios, J., Dirección de Investigaciones Epidemiológicas y Sociales, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, United States; Mudalige, I.U.K., Department of Psychiatry, Faculty of Medicine, Sir John Kotelawala Defence University, Sri Lanka; Mukherjee, D., Centre for Addiction Medicine, NIMHANS, Bangalore, India; Munira, P.M., Kleopatra Kodric, Irena Nisic, Slovenia; Myers, B., Alcohol Tobacco and Other Drug Research Unit, South African Medical Research Council, South Africa; Menon T. N., J., NIMHANS, Bangalore, India; Narasimha, V.L., Centre for Addiction Medicine, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, India; Ndionuka, N., Federal Neuropsychiatric Hospital, Calabar, Nigeria; Nejatisafa, A.-A., Department of Psychiatry, Psychosomatic Research Center, Tehran University of Medical Sciences, Tehran, Iran; Niaz, K., United Nations Office on Drugs and Crime (UNODC), Vienna, Austria; Nizami, A.T., Institute of Psychiatry, WHO Collaborating Center for Mental Health, Pakistan; Nuijens, J.H., Brijder Addiction Care, Zaandam, Netherlands; Orsolini, L., Department of Clinical Neurosciences/DIMSC, School of Medicine, Polytechnic University of Marche, Ancona, Italy; Oum, V., Koh Kong Provincial Hospital, Cambodia; Oyemade, A.A., Kaiser Permanente, United States; Palavra, I.R., Psychiatric hospital Sveti Ivan, Zagreb, Croatia; Pant, S.B., Department of Psychiatry and mental health, Institute of Medicine, Tribhuvan University, Nepal; Paredes, J., Universidad de El Salvador, El Salvador; Peyron, E., AddiPsy, Lyon, France; Quirós, R.A., Addiction Medicine Clinic, Costa Rica; Qurishi, R., Novadic-Kentron Addiction Care Network, Vught, Netherlands; Rafiq, N.U.Z., Phoenix Foundation for Research and Development, Pakistan; Raghavendra Rao, R., Barwon Health, Geelong, Australia; Ratta-Apha, W., Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand; Raymond, K.-L., University of the Sunshine Coast (USC)QLD, Australia; Reimer, J., Center for Interdisciplinary Addiction Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Renaldo, E., Drugs Rehabilitation Center, National Narcotics Board of Indonesia; Rezapour, T., Department of Cognitive Psychology, Institute for Cognitive Science Studies, Tehran, Iran; Robertson, J.R., Usher Institute, University of Edinburgh, United Kingdom; Roncero, C., Psychiatry Service, University of Salamanca Health Care Complex, Salamanca, Spain; Roub, F., PGIMER, Chandigarh, India; Rubenstein, E.J., Street Health Centre, Canada; Rupp, C.I., Department of Psychiatry, Psychotherapy, and Psychosomatics, Medical University Innsbruck, Austria; Saenz, E., United Nations Office on Drugs and Crime (UNODC), Vienna, Austria; Salehi, M., Department of Neurosciences and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; Samartzis, L., Medical School, University of Cyprus, Cyprus; Sarubbo, L.B., Clínica Psiquiátrica de la Facultad de Medicina, Uruguay; Segrec, N., Center for Treatment of Drug addiction, University Psychiatric Clinic, Ljubljana, Slovenia; Shah, B., Department of Psychiatry, Patan Academy of Health Sciences, School of Medicine, Lagankhel, Nepal; Shen, H., Department of Psychiatry, Second Xiangya Hospital, Central South University, China; Shirasaka, T., Department of Psychiatry, Teine Keijinkai Medical Center, Japan; Shoptaw, S., David Geffen School of Medicine at UCLA, Department of Family Medicine, United States; Sintango, F.M., Health Professions Councils of Namibia, Namibia; Sosa, V.A., Addiction Medicine Clinic, Uruguay; Subata, E., Republican Center for Addictive Disorders, Lithuania; Sztycberg, N., Asociasion Programa Andres Argentina, Argentina; Taghizadeh, F., Mazandaran University of Medical Sciences, Mazandaran, Iran; Wee Teck, J.B.T., MRC/CSO SPHSU, University of Glasgow, United Kingdom; Tjagvad, C., Gladsaxe Substance Use Disorder Treatment Centre, Denmark; Torrens, M., Institut de Neuropsiquiatria i Addiccions, IMIM-Hospital del Mar, Medical Research, Barcelona, Spain; Twala, J.M., NACADA, Kenya; Vadivel, R., Waikato District Health Board (WDHB, Hamilton, New Zealand; Volpicelli, J.R., Institute of Addiction Medicine, United States; Weijs, J., Jellinek, Amsterdam, Netherlands; Wintoniw, S.M., Addictions Foundation of Manitoba, Canada; Wittayanookulluk, A., Thanyarak Chiangmai Hospital, Thailand; Wojnar, M., Medical University of Warsaw, Warsaw, Poland; Yasir, S., Institute of Psychiatry, WHO Collaborating Center for Mental Health, Pakistan; Yitayih, Y., Jimma University, Ethiopia; Zhao, M., Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, China; ISAM Global Survey Consortium (ISAM-GSC) |
Background and Aims: COVID-19 has infected more than 77 million people worldwide and impacted the lives of many more, with a particularly devastating impact on vulnerable populations, including people with substance use disorders (SUDs). Quarantines, travel bans, regulatory changes, social distancing, and “lockdown” measures have affected drug and alcohol supply chains and subsequently their availability, price, and use patterns, with possible downstream effects on presentations of SUDs and demand for treatment. Given the lack of multicentric epidemiologic studies, we conducted a rapid global survey within the International Society of Addiction Medicine (ISAM) network in order to understand the status of substance-use patterns during the current pandemic. Design: Cross-sectional survey. Setting: Worldwide. Participants: Starting on April 4, 2020 during a 5-week period, the survey received 185 responses from 77 countries. Measurements: To assess addiction medicine professionals' perceived changes in drug and alcohol supply, price, use pattern, and related complications during the COVID-19 pandemic. Findings: Participants reported (among who answered “decreased” or “increased”) a decrease in drug supply (69.0%) and at the same time an increase in price (95.3%) globally. With respect to changes in use patterns, an increase in alcohol (71.7%), cannabis (63.0%), prescription opioids (70.9%), and sedative/hypnotics (84.6%) use was reported, while the use of amphetamines (59.7%), cocaine (67.5%), and opiates (58.2%) was reported to decrease overall. Conclusions: The global report on changes in the availability, use patterns, and complications of alcohol and drugs during the COVID-19 pandemic should be considered in making new policies and in developing mitigating measures and guidelines during the current pandemic (and probable future ones) in order to minimize risks to people with SUD. © Copyright © 2021 Farhoudian, Radfar, Mohaddes Ardabili, Rafei, Ebrahimi, Khojasteh Zonoozi, De Jong, Vahidi, Yunesian, Kouimtsidis, Arunogiri, Hansen, Brady, ISAM Global Survey Consortium (ISAM-GSC), Potenza, Baldacchino and Ekhtiari. |
addiction; behavioral addiction; COVID-19; global survey; illicit drug market; substance use disorder |
alcohol; cannabis; illicit drug; addiction medicine; adult; Article; coronavirus disease 2019; drug bioavailability; drug industry; female; gambling; health care personnel; health service; human; male; pandemic; pharmacist; prescription; questionnaire; substance use |
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