No records
|
890 |
Elliyanti A., Rustam R., Tofrizal T., Yenita Y., Susanto Y.D.B. |
57217097313;57210705603;57219663511;57221789235;57197866044; |
Evaluating the natrium iodide symporter expressions in thyroid tumors |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
B |
|
18 |
23 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100161267&doi=10.3889%2foamjms.2021.5534&partnerID=40&md5=f5dd69104ea66dab03a6a98ac2928162 |
Department of Medical Physics, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Division of Nuclear Medicine, Department of Radiology, Dr. M.Djamil Hospital, Padang, Indonesia; Department of Surgery, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Department of Pathology Anatomy, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Elliyanti, A., Department of Medical Physics, Faculty of Medicine, Universitas Andalas, Padang, Indonesia, Division of Nuclear Medicine, Department of Radiology, Dr. M.Djamil Hospital, Padang, Indonesia; Rustam, R., Department of Surgery, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Tofrizal, T., Department of Pathology Anatomy, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Yenita, Y., Department of Pathology Anatomy, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Susanto, Y.D.B., Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND: Decreased Natrium iodide symporter (NIS) expression levels or diminished NIS targeting thyroid cancer cells’ plasma membrane leads to radioiodine-refractory disease. AIM: The aim of this study was to analyze the NIS expression in thyroid tumors. MATERIALS AND METHODS: The samples were thyroid tissues of patients who underwent surgery for a thyroid tumor. The tissues were processed for NIS protein expressions by immunohistochemistry (IHC) and Western blot (WB). Graves’ disease samples were used as positive controls. The samples were incubated without the primary antibody, and they were used as negative controls for IHC examination. Na+/K+ ATPase was a plasma membrane protein marker in the WB procedure. RESULTS: Twenty-nine samples were assessed for NIS protein. All of them showed the expression in the cytoplasm with intensity 1+ to 3+ with Allred score 3-8. Fourteen out of 29 cases (48.2%) showed NIS cytoplasm staining intensity ≥2+ consist of 10 papillary thyroid cancer (PTC), three follicular thyroid cancer, and one adenoma. Membrane staining was found in 2 samples of PTC (6.9%). Six samples (adenoma 1 sample, PTC 5 samples) showed NIS expression at membrane very weak (1+); they were considered as negative. NIS protein has several bands of ~ 80 kDa, ~ 62 kDa, and ~ 49 kDa. CONCLUSION: NIS expression in thyroid cancer mostly expresses in the cytoplasm instead of the membrane. NIS will play a functional role in the membrane to bring iodine across the membrane against the concentration. It can be the main reason for the lack of response of radioiodine in some differentiated thyroid cancers. © 2021 Aisyah Elliyanti, Rony Rustam, Tofrizal Tofrizal, Yenita Yenita, Susanto YDB. |
Follicular thyroid cancer; Immunohistochemistry; Membrane staining; Papillary thyroid cancer; Western blot |
|
Open Access Macedonian Journal of Medical Sciences |
18579655 |
|
|
Article |
Q3 |
288 |
15252 |
|
|
892 |
Dwinata M., Putera D.D., Hasan I., Raharjo M. |
57209231012;57210288025;12776850800;57212400550; |
SGLT2 inhibitors for improving hepatic fibrosis and steatosis in non-alcoholic fatty liver disease complicated with type 2 diabetes mellitus: a systematic review |
2021 |
Clinical and Experimental Hepatology |
6 |
4 |
|
339 |
346 |
|
1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099931230&doi=10.5114%2fceh.2020.102173&partnerID=40&md5=628a477d8f6d02f9de989db2ce816c8c |
Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Hepatobiliary Division, Department of Internal Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Dwinata, M., Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Putera, D.D., Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Hasan, I., Hepatobiliary Division, Department of Internal Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Raharjo, M., Hepatobiliary Division, Department of Internal Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Aim of the study: To evaluate the efficacy of sodium/glucose cotransporter-2 inhibitors (SGLT2i) in improving hepatic fibrosis and steatosis of non-alcoholic fatty liver disease (NAFLD) patients with type 2 diabetes mellitus (T2DM). Material and methods: We searched CENTRAL, MEDLINE, and EMBASE and included any clinical trials involving patients with NAFLD and T2DM aged ≥ 18 years comparing efficacy of SGLT2i and other antidiabetic drugs in improving fibrosis and steatosis, irrespective of publication status, year of publication, and language. Results: Five clinical trials were included. One study reported significant improvements in the controlled attenuation parameter 314.6 ±61.0 dB/m to 290.3 ±72.7 dB/m (p = 0.04) in the SGLT2i group measured by transient elastography. In patients with significant fibrosis, dapagliflozin treatment significantly decreased the liver stiffness measurement from 14.7 ±5.7 kPa at baseline to 11.0 ±7.3 kPa after 24 weeks (p = 0.02). One study reported a significant decrease in liver fat content 16.2% to 11.3% (p < 0.001) in the SGLT2i group compared to the control (p < 0.001). Three studies reported significant improvement in the liver-to-spleen ratio in the SGLT2i group after treatment 0.96 (0.86-1.07) to 1.07 (0.98-1.14), p < 0.01, 0.80 ±0.24 to 1.00 ±0.18, p < 0.001, and 0.91 (0.64-1.04) to 1.03 (0.80-1.20), p < 0.001 respectively. All studies reported a significant decrease in alanine aminotransferase with SGLT2i. Conclusions: SGLT2i is associated with positive effects on hepatic steatosis measured by non-invasive modalities. Further studies are needed to confirm the impact of SGLT2i on hepatic fibrosis and steatosis. © 2020 Termedia Publishing House Ltd.. All rights reserved. |
Diabetes mellitus; Fibrosis; NAFLD; SGLT2 inhibitor; Steatosis |
alanine aminotransferase; dapagliflozin; empagliflozin; ipragliflozin; luseogliflozin; metformin; pioglitazone; sodium glucose cotransporter 2 inhibitor; adult; aged; alanine aminotransferase blood level; Article; comparative effectiveness; controlled study; diabetic patient; drug efficacy; elastography; female; human; liver fibrosis; liver stiffness; major clinical study; male; middle aged; non insulin dependent diabetes mellitus; nonalcoholic fatty liver; quasi experimental study; randomized controlled trial; systematic review; transient elastography; treatment outcome |
Termedia Publishing House Ltd. |
23921099 |
|
|
Article |
Q4 |
394 |
12273 |
|
|
894 |
Sandhiutami N.M.D., Arozal W., Louisa M., Rahmat D. |
56692904000;32067462200;41461551400;36673726800; |
Determine Curcumin Concentration in Organ Rats and in Ovaries at Ovarian Cancer Model Rats Using Ultra Performance Liquid Chromatography-Mass Spectrometry (Ms)/Ms |
2021 |
Pharmaceutical Sciences Asia |
48 |
1 |
|
37 |
45 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099915596&doi=10.29090%2fPSA.2021.02.19.146&partnerID=40&md5=59970a9906f368c7cd760cdd0765143e |
Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Sandhiutami, N.M.D., Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia; Arozal, W., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahmat, D., Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia |
Curcumin has several pharmacological effects including anti-inflammatory, reduce kidney damage, hepatoprotector, and inhibiting tumor growth in ovarian cancer. The use of curcumin is limited because it has low bioavailability and low capacity to reach target organs. This limitation is overcome by making it in the form of nanoparticles. This study aim to determine curcumin levels on some organ in healthy rat groups and on ovaries at ovarian cancer models rat that given curcumin and curcumin nanoparticles. Measurement of curcumin levels using UPLC-MS/MS. Determination of curcumin level in the organ was carried out in 2 treatment groups, group that received curcumin and group that received curcumin nanoparticles orally with a single dose of 100 mg/kg Body Weight (BW). At 180 minutes, rats were decapitated for liver, kidney and ovaries. The ovarian cancer rats were also divided into 2 groups and given curcumin and curcumin nanoparticles with repeated doses of 100 mg/kgBW/day and after 30 days, ovarian cancer rats were decapitated for the ovaries. In the group that received curcumin, the concentration of curcumin in the liver, kidney and ovaries were less than the detection limit, whereas in the group that received curcumin nanoparticles, the levels of curcumin are 1,866.6±22.60 ng/g in liver, 114.87±13.36 ng/g in kidney and 136.864±11.15 ng/g in ovaries. In ovarian cancer rats, levels of curcumin in the group receiving curcumin is 2.29±1.15 ng/g and 17.76±4.85 ng/g in the group receiving curcumin nanoparticles. Curcumin nanoparticles can increase the distribution of curcumin in liver, kidney, ovaries in healthy rats and in ovaries at ovarian cancer model rats. © 2020. All Rights Reserved. |
curcumin; curcumin nanoparticles; ovarian cancer rats; rats organ; UPLC MS/MS |
curcumin; nanoparticle; animal experiment; animal model; animal tissue; Article; cancer model; controlled study; drug determination; drug distribution; drug liver level; female; kidney homogenate; limit of detection; limit of quantitation; liquid chromatography-mass spectrometry; liver homogenate; measurement accuracy; measurement precision; nonhuman; ovary; ovary cancer; rat; repeated drug dose; single drug dose |
Mahidol University - Faculty of Pharmacy |
25868195 |
|
|
Article |
Q3 |
144 |
23834 |
|
|
895 |
Tarigan T.J.E., Dwijayanti A., Setyowati S., Louisa M. |
36057746500;55743787900;54893136300;41461551400; |
Immunogenicity and efficacy of insulin glargine biosimilar ezelin versus originator insulin glargine in patients with type 2 diabetes |
2021 |
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy |
14 |
|
|
107 |
116 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099828801&doi=10.2147%2fDMSO.S279385&partnerID=40&md5=4adefbb901a3483328866d6334ab8e3d |
Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Endocrinology, Department of Internal Medicine, Gatot Soebroto Presidential Hospital, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Tarigan, T.J.E., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Dwijayanti, A., Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setyowati, S., Division of Endocrinology, Department of Internal Medicine, Gatot Soebroto Presidential Hospital, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Purpose: To compare the immunogenicity and efficacy of insulin glargine biosimilar Ezelin (EZL) versus originator insulin glargine Lantus (LAN) as a reference basal insulin in patients with type 2 diabetes (T2D). Patients and Methods: This was a randomized, multicenter, open-label, 24-week study in insulin-naïve patients with T2D, with HbA1c of >7.0%. We randomly assigned 133 eligible patients to receive either EZL or LAN. Baseline characteristics, including insulin autoantibody (IAA), zinc transporter 8 (ZnT8) antibody, HbA1C, fasting plasma glucose (FPG), 2-hour postprandial plasma glucose (2hPPG), AST, ALT, BUN, eGFR, and oral antidiabetic drugs, were obtained before starting insulin treatment. After starting treatment, insulin dose was titrated to achieve FPG target along with oral antidiabetic drugs. Patients were given home glucometer and assisted to record plasma glucose measurement and adverse event (AE). Every month, patients came to the diabetes clinic and performed a regular physical examination and intensifying treatment if needed. Out of the 133 randomized patients, only 122 completed the study and can be examined for their IAA and ZnT8 after 6 months of treatment. The study was registered in clinicaltrials.gov, NCT03352674. Results: There is a similar proportion of patients with changes of IAA from baseline: 1 out of 58 (1.7%) patients receiving EZL versus 1 out of 64 (1.6%) patients receiving LAN (p = 1.000). One patient in the EZL group (1.7%) versus none in the LAN group experienced a change of ZnT8 antibody from baseline. Similar glucose control in EZL versus LAN was determined by the change in HbA1c, FPG, and 2hPPG (−2.0%, −67.46 mg/dL, and −76.51 mg/dL in the EZL group versus −1.7%, −58.11 mg/dL, and −70.03 mg/dL in the LAN group). There were six events of documented hypoglycemia in the EZL group versus five events in the LAN group. No patients experienced diabetic ketoacidosis during the study. Conclusion: Overall, insulin glargine biosimilar EZL and originator insulin glargine LAN have shown a similar immunogenicity profile, as well as efficacy in providing glucose control and safety findings in T2D populations. © 2021 Tarigan et al. |
Biosimilar; Hyperglycemia; Insulin autoantibody; Zinc transporter 8 antibody |
acarbose; alanine aminotransferase; aspartate aminotransferase; ezelin; glucose; hemoglobin A1c; insulin antibody; insulin glargine; metformin; pioglitazone; protein antibody; sulfonylurea; unclassified drug; urea; zinc transporter 8; zinc transporter 8 antibody; acute gastroenteritis; acute kidney failure; adult; alanine aminotransferase blood level; Article; aspartate aminotransferase blood level; Bell palsy; cardiovascular disease; cerebrovascular accident; cervical spine fracture; controlled study; coughing; dermatitis; diabetic ketoacidosis; diabetic patient; diabetic ulcer; diarrhea; drug dose titration; drug efficacy; drug safety; dyspepsia; dyspnea; estimated glomerular filtration rate; fasting; female; gangrene; gastritis; gastroesophageal reflux; gastrointestinal symptom; glucose |
Dove Medical Press Ltd |
11787007 |
|
|
Article |
Q2 |
853 |
5525 |
|
|
897 |
Oshima T., Siah K.T.H., Kim Y.S., Patcharatrakul T., Chen C.-L., Mahadeva S., Park H., Chen M.-H., Lu C.-L., Hou X., Quach D.T., Syam A.F., Rahman M.M., Xiao Y., Jinsong L., Chua A.S.B., Miwa H. |
7401663152;35757936600;57196171210;8549899200;23495616400;6602694336;56255219600;57216452428;7404805612;57210061408;37099075800;8443384400;57216556340;23500436000;57221693058;7004518894;56921458500; |
Knowledge, attitude, and practice survey of gastroparesis in asia by asian neurogastroenterology and motility association |
2021 |
Journal of Neurogastroenterology and Motility |
27 |
1 |
|
46 |
54 |
|
5 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099728456&doi=10.5056%2fJNM20117&partnerID=40&md5=49d79381fdad1a0dca816161fd54b8e0 |
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore, Singapore; Digestive Disease Research Institute, School of Medicine, Wonkwang University, Iksan, Jeollabuk-do, South Korea; Center of Excellence in Neurogastroenterology and Motility, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Division of Gastroenterology, Department of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand; Department of Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien, Taiwan; Institute of Medical Sciences, College of Medicine, Tzu Chi University, Hualien, Taiwan; Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University, Seoul, South Korea; Department of Gastroenterology and Hepatology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Endoscopy Center for Diagnosis and Treatment, Taipei Veterans General Hospital, Taipei, Taiwan; Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Internal Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh, Viet Nam; Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta Pusat, Indonesia; Department of Gastroenterology, Sheikh Russel National Gastroliver Institute and Hospital, Dhaka, Bangladesh; Gastro Center Ipoh, Ipoh, Malaysia |
Oshima, T., Division of Gastroenterology and Hepatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan; Siah, K.T.H., Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore, Singapore; Kim, Y.S., Digestive Disease Research Institute, School of Medicine, Wonkwang University, Iksan, Jeollabuk-do, South Korea; Patcharatrakul, T., Center of Excellence in Neurogastroenterology and Motility, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, Division of Gastroenterology, Department of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand; Chen, C.-L., Department of Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien, Taiwan, Institute of Medical Sciences, College of Medicine, Tzu Chi University, Hualien, Taiwan; Mahadeva, S., Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Park, H., Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University, Seoul, South Korea; Chen, M.-H., Department of Gastroenterology and Hepatology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Lu, C.-L., Endoscopy Center for Diagnosis and Treatment, Taipei Veterans General Hospital, Taipei, Taiwan; Hou, X., Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Quach, D.T., Department of Internal Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh, Viet Nam; Syam, A.F., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta Pusat, Indonesia; Rahman, M.M., Department of Gastroenterology, Sheikh Russel National Gastroliver Institute and Hospital, Dhaka, Bangladesh; Xiao, Y., Department of Gastroenterology and Hepatology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Jinsong, L., Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Chua, A.S.B., Gastro Center Ipoh, Ipoh, Malaysia; Miwa, H., Division of Gastroenterology and Hepatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan |
Background/Aims Gastroparesis is identified as a subject that is understudied in Asia. The scientific committee of the Asian Neurogastroenterology and Motility Association performed a Knowledge, Attitude, and Practices survey on gastroparesis among doctors in Asia. Methods The questionnaire was created and developed through a literature review of current gastroparesis works of literature by the scientific committee of Asian Neurogastroenterology and Motility Association. Results A total of 490 doctors from across Asia (including Bangladesh, China, Hong Kong, Indonesia, Japan, Malaysia, Myanmar, the Philippines, Singapore, South Korea, Taiwan, Thailand, and Vietnam) participated in the survey. Gastroparesis is a significant gastrointestinal condition. However, a substantial proportion of respondents was unable to give the correct definition and accurate diagnostic test. The main reason for lack of interest in diagnosing gastroparesis was "the lack of reliable diagnostic tests"(46.8%) or "a lack of effective treatment"(41.5%). Only 41.7% of respondents had access to gastric emptying scintigraphy. Most doctors had never diagnosed gastroparesis at all (25.2%) or diagnosed fewer than 5 patients a year (52.1%). Conclusions Gastroparesis can be challenging to diagnose due to the lack of instrument, standardized method, and paucity of research data on normative value, risk factors, and treatment studies in Asian patients. Future strategies should concentrate on how to disseminate the latest knowledge of gastroparesis in Asia. In particular, there is an urgent need to estimate the magnitude of the problems in high risk and idiopathic patients as well as a standardized diagnostic procedure in Asia. © 2021 The Korean Society of Neurogastroenterology and Motility. |
Asia; Dyspepsia; Gastroparesis; Health care surveys; Health education |
Article; Asia; Bangladesh; China; demography; diagnostic test; female; Hong Kong; human; Indonesia; Japan; knowledge; Malaysia; male; medical society; Myanmar; Philippines; physician attitude; questionnaire; scintigraphy; Singapore; South Korea; stomach emptying; stomach paresis; Taiwan; test meal; Thailand; Viet Nam |
Korean Society of Neurogastroenterology and Motility |
20930879 |
|
|
Article |
Q1 |
1345 |
2715 |
|
|
899 |
Tanto I.V., Dharma S., Juzar D.A., Bono A.A.H. |
57221612652;55101301700;55358712500;57208146721; |
Ventricular Septal Rupture Complicating an Acute ST-Segment Elevation Myocardial Infarction during the COVID-19 Pandemic |
2021 |
International Journal of Angiology |
|
|
|
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099596441&doi=10.1055%2fs-0040-1720971&partnerID=40&md5=aab866db219c647750534315d55f3fdf |
Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jl S Parman Kav 87, Slipi, Jakarta Barat, Jakarta, 11420, Indonesia; Division of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
Tanto, I.V., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jl S Parman Kav 87, Slipi, Jakarta Barat, Jakarta, 11420, Indonesia; Dharma, S., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jl S Parman Kav 87, Slipi, Jakarta Barat, Jakarta, 11420, Indonesia; Juzar, D.A., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jl S Parman Kav 87, Slipi, Jakarta Barat, Jakarta, 11420, Indonesia; Bono, A.A.H., Division of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
Ventricular septal rupture (VSR) is rare but a lethal complication of acute myocardial infarction (MI). Definite treatment requires the surgical closure of the VSR and coronary artery bypass grafting (CABG). However, the optimal timing for surgery is still controversial, particularly during the novel coronavirus disease 2019 (COVID-19) pandemic where medical procedures should be performed within the safest environment. Before surgery, a proper management in the intensive cardiovascular care unit is essential to maintain the stability of the hemodynamic profile related with VSR and determines the prognosis of the patient. We described a case of VSR complicating an anterior wall MI in a patient who admitted to our hospital during the COVID-19 pandemic that was treated successfully by surgical closure of the VSR and CABG. © 2021 BMJ Publishing Group. All rights reserved. |
bypass grafting; myocardial infarction; surgical repair; ventricular septal rupture |
|
Thieme Medical Publishers, Inc. |
10611711 |
|
|
Article |
Q3 |
293 |
15070 |
|
|
900 |
Pulungan A.B., Fadiana G., Annisa D. |
57192905981;57221614963;57205770955; |
Type 1 diabetes mellitus in children: Experience in Indonesia |
2021 |
Clinical Pediatric Endocrinology |
30 |
1 |
|
11 |
18 |
|
2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099564628&doi=10.1297%2fcpe.30.11&partnerID=40&md5=aba5de1c98be7c8ac4cc9cdd9a7ff21b |
Child Health Department, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Pulungan, A.B., Child Health Department, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Fadiana, G., Child Health Department, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Annisa, D., Child Health Department, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
The prevalence of type 1 diabetes mellitus (T1DM) in children in Indonesia is increasing although the real number is unknown due to high rate of misdiagnosis. Public and healthcare awareness on T1DM in children is still low, reflected by the high number of children diagnosed with diabetic ketoacidosis (DKA). The Indonesian Pediatric Society (IPS) had published a guideline on T1DM management, which consists of insulin injection, daily monitoring of blood glucose, nutrition, physical activity, and education. Aside from low awareness, current challenges on T1DM management in Indonesia are funding by the national health insurance, fasting during Ramadan, and inequities on DM care. The involvement of society, healthcare workers, stakeholders, and the government is of importance to ensure optimal management for children with diabetes. © 2021 by The Japanese Society for Pediatric Endocrinology. |
Children; Diabetes; Indonesia; Type 1 diabetes mellitus (T1DM) |
hemoglobin A1c; immunologic factor; insulin; vitamin D; awareness; blood glucose monitoring; blurred vision; body mass; body weight loss; caloric intake; carbohydrate intake; clinical article; diabetic ketoacidosis; diabetic retinopathy; education; endocrinologist; epigenetics; food intake; glucose blood level; glycemic control; health care personnel; health insurance; health survey; human; hyperglycemia; hyperphagia; hypertension; hypocalcemia; hypoglycemia; insulin dependent diabetes mellitus; insulin resistance; insulin sensitivity; insulin treatment; insulinoma; ketoacidosis; ketonuria; metabolic regulation; microalbuminuria; national health insurance; nocturia; non insulin dependent diabetes mellitus; nutrition; obesity; oral glucose tolerance test; pediatrician; physical activity; po |
Jeff Corporation Co. Ltd |
09185739 |
|
|
Review |
Q2 |
461 |
10790 |
|
|
902 |
Bahtiar A., Miranda A.J., Arsianti A. |
35365874400;57221531432;36124567000; |
The effect of artocarpus altilis (parkinson) fosberg extract supplementation on kidney ischemia-reperfusion injury rat |
2021 |
Pharmacognosy Journal |
13 |
1 |
|
150 |
154 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099365078&doi=10.5530%2fpj.2021.13.21&partnerID=40&md5=13b866767b1597a22566e8ac646a0b9f |
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Department of Medicinal Chemistry, Faculty of Medicine, Universitas Indonesia, Kampus UI Salemba, Jakarta, Indonesia |
Bahtiar, A., Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Miranda, A.J., Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Arsianti, A., Department of Medicinal Chemistry, Faculty of Medicine, Universitas Indonesia, Kampus UI Salemba, Jakarta, Indonesia |
Background: Acute kidney injury (AKI) is a kidney disease resulting in high morbidity and mortality levels in humans. One of the disorders classified as AKI is ischemia-reperfusion injury (IRI), characterized by two phases. The first phase is Ischemia in the kidneys due to obstruction of the renal arteries or veins, followed by the second phase, which is the occurrence of reperfusion with blood flowing back in the renal arteries veins. The aim of this current research is to analyze the efficacy of Artocarpus altilis on Kidney ischemia-reperfusion model rats. Methods: To this end, first, we established Ischaemia-reperfusion kidney injury rat. We then evaluated the Artocarpus altilis extract on IRI model rats. A total of 36 rats have grouped into six groups. Group I is the Sham group, Group II is the negative control group, Group III is the positive control group (vitamin C 100 mg/kg BW), Group IV is Dose I of Artocarpus altilis extract 50 mg/kg BW), Group V is Dose II Artocarpus altilis extract 100 mg/kg BW), Group VI is Dose III Artocarpus altilis extract 200 mg/kg BW). The vitamin C and Artocarpus altilis extract administered 14 days before and after Ischemia-reperfusion treatment. At day 0, Ischemia was made by bilateral renal pedicle clamping method for 30 minutes, sacrificed 14 days after reperfusion. The blood and histology samples were collected on day 0, a day after reperfusion, at 24 hrs after reperfusion, at 48 hrs after reperfusion, and 14 days after treatment. Results: The clamping duration of 30 minutes leads to achieving the most representative clinical IRI conditions. It shows the most significant recovery of injury conditions within the 14-day reperfusion period in IRI animal models, making it ideal for IRI operations for the preliminary test. The administration of 100 mg/kg BW of Artocarpus altilis extract could reduce the malondialdehyde plasma compared with the sham group. The SOD and Catalase activity showed improvement after reperfusion. Conclusion: Artocarpus altilis extracts showed antioxidant activity to prevent the kidney from ischemia-reperfusion injury by modulated SOD and Catalase. © 2021 Phcogj.Com. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license. |
Acute kidney disease; Artocarpus altilis (Parkinson) Fosberg; Free radicals; Reperfusion injury; Sukun |
antiinflammatory agent; antioxidant; Artocarpus altilis extract; ascorbic acid; catalase; creatinine; malonaldehyde; nitrogen; plant extract; protective agent; superoxide dismutase; unclassified drug; urea; animal experiment; animal model; animal tissue; antiinflammatory activity; antioxidant activity; Article; blood sampling; controlled study; creatinine blood level; dose response; drug efficacy; enzyme activity; enzyme blood level; glomerulus filtration rate; histopathology; male; nonhuman; rat; renal ischemia reperfusion injury; renal protection; supplementation; treatment duration; urea nitrogen blood level |
EManuscript Technologies |
09753575 |
|
|
Article |
Q3 |
268 |
15961 |
|
|
903 |
Kusmardi K., Wiyarta E., Estuningtyas A., Sahar N., Midoen Y.H., Tedjo A. |
56966625300;57221521342;55650360200;57212464367;57197805109;57189320451; |
Potential of phaleria macrocarpa leaves ethanol extract to upregulate the expression of caspase-3 in mouse distal colon after dextran sodium sulphate induction |
2021 |
Pharmacognosy Journal |
13 |
1 |
|
23 |
29 |
|
2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099343021&doi=10.5530%2fpj.2021.13.4&partnerID=40&md5=8dd1b8ac126d5a96f41668c2f3066c1f |
Department of Anatomic Pathology, Drug Development Research Cluster, Human Cancer Research Center, IMERI, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Department Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia |
Kusmardi, K., Department of Anatomic Pathology, Drug Development Research Cluster, Human Cancer Research Center, IMERI, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Wiyarta, E., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Estuningtyas, A., Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Sahar, N., Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Midoen, Y.H., Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Tedjo, A., Department Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia |
Ulcerative colitis (UC) is a part of incurable chronic inflammatory disease that has gained importance over the past few decades. A lot of research has been done to find effective treatments for UC, one of which is herbal medicine. Phaleria macrocarpa (PM), an Indonesian native plant, is thought to be an alternative therapy for UC because of its anti-inflammatory properties. Therefore, in this research, Phaleria macrocarpa Leaves Ethanol Extract (PMLEE) is used to assess its effect on UC by using Caspase-3 as apoptosis marker. PMLEE was made from dried material of PM that undergo maceration. Animals were separated into six groups: normal, negative control, positive control, and PMLEE groups (100, 200, 300 mg/kgBW). PMLEE was then injected to BALB/c mice that have been induced by dextran sodium sulphate (DSS) for 7 consecutive days. DSS is used to model UC in mice colon tissue. All animals were sacrificed and their colons were collected then stained with anti-Caspase-3. The stained sections were subsequently examined with ImageJ based on color intensity which generated H-Score as the results. Based on H-Score of each group, PMLEE 300mg has significantly upregulate the expression of Caspase-3 compare to the negative control (p=0.015). PMLEE also has a tendency to be dose dependent based on the significant difference between PMLEE doses. Therefore, it concludes that PMLEE is able to upregulate the expression of Caspase-3 in colon cells as in this study it was directly proportional. © 2021 Phcogj.Com. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license. |
Apoptosis; Inflammation; Mahkota Dewa; Ulcerative colitis |
acetylsalicylic acid; alcohol; antiinflammatory agent; apoptotic protease activating factor 1; caspase 3; cytochrome c; dextran sulfate; Phaleria macrocarpa extract; plant extract; unclassified drug; animal cell; animal experiment; animal model; animal tissue; antiinflammatory activity; apoptosis; Article; cell death; cell proliferation; colon tissue; controlled study; descending colon; dysplasia; medicinal plant; mitochondrion; mouse; nonhuman; Phaleria macrocarpa; plant leaf; protein expression; ulcerative colitis; upregulation |
EManuscript Technologies |
09753575 |
|
|
Article |
Q3 |
268 |
15961 |
|
|
904 |
Widaty S., Soebono H., Sunarto, Emilia O. |
57208261546;6508242918;57221528270;6504322013; |
Development of a new instrument to assess clinical performance of residents in dermatology-Venereology department |
2021 |
Asia Pacific Scholar |
6 |
1 |
|
70 |
82 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099335332&doi=10.29060%2fTAPS.2021-6-1%2fOA2241&partnerID=40&md5=7ccb3f67cc4a32f511df79fd292001b5 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Indonesia; Department of Dermatology and Venereology Faculty of Medicine, Universitas Gadjah Mada, Indonesia; Pediatric Department, Faculty of Medicine, Universitas Gadjah Mada Indonesia, Indonesia; Medical Education Department, Faculty of Medicine, Universitas Gadjah Mada, Indonesia |
Widaty, S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Indonesia; Soebono, H., Department of Dermatology and Venereology Faculty of Medicine, Universitas Gadjah Mada, Indonesia; Sunarto, Pediatric Department, Faculty of Medicine, Universitas Gadjah Mada Indonesia, Indonesia; Emilia, O., Medical Education Department, Faculty of Medicine, Universitas Gadjah Mada, Indonesia |
Introduction: Performance assessment of residents should be achieved with evaluation procedures, informed by measured and current educational standards. The present study aimed to develop, test, and evaluate a psychometric instrument for evaluating clinical practice performance among Dermatology and Venereology (DV) residents. Methods: This is a qualitative and quantitative study conducted from 2014 to 2016. A pilot instrument was developed by 10 expert examiners from five universities to rate four video-recorded clinical performance, previously evaluated as good and bad performance. The next step was the application of the instrument to evaluate the residents which was carried out by the faculty of DV at two Universities. Results: The instrument comprised 11 components. There was a statistically significant difference (p < 0.001) between good and bad performance. Cronbach’s alpha documented high overall reliability (α = 0.96) and good internal consistency (α = 0.90) for each component. The new instrument correctly evaluated 95.0% of poor performance. The implementation study showed that inter-rater reliability between evaluators range from low to high (correlation coefficient α =0.79, p < 0.001). Conclusion: The instrument is a reliable and valid instrument for assessing clinical practice performance of DV residents. More studies are required to evaluate the instrument in different situation. © 2021 TAPS. All rights reserved. |
Clinical Assessment; Dermatology-Venereology; Instrument; Performance; Resident; Workplace-Based Assessment |
|
National University of Singapore, Faculty of Law |
24249335 |
|
|
Article |
#N/A |
#N/A |
#N/A |
|
|