No records
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31 |
Nusanti S., Dearaini, Bani A.P., Kartasasmita A.S., Ichsan A.M., Virgana R., Anggraini N., Rahayu T., Irfani I., Edwar L., Rifada M., Yudantha A.R., Ismail M.A., Komaratih E., Wildan A., Knoch A.M.H. |
57189727162;57386841000;53663268800;37002851300;57218514954;56922099400;57387397200;57208305374;57201131541;55695047800;55249679300;55489644900;57386650700;57204192624;57205025156;57386841100; |
Delivering a modified continuous objective structured clinical examination for ophthalmology residents through a hybrid online method |
2021 |
Korean Journal of Medical Education |
33 |
4 |
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419 |
430 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121800362&doi=10.3946%2fkjme.2021.210&partnerID=40&md5=f12d396df59aa176538ef352c359c609 |
Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Ophthalmology, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia; Department of Ophthalmology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Department of Ophthalmology, Faculty of Medicine, Airlangga University, Surabaya, Indonesia; Department of Ophthalmology, Faculty of Medicine, Diponegoro University, Semarang, Indonesia |
Nusanti, S., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Dearaini, Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Bani, A.P., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kartasasmita, A.S., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia; Ichsan, A.M., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Virgana, R., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia; Anggraini, N., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahayu, T., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Irfani, I., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia; Edwar, L., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rifada, M., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yudantha, A.R., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ismail, M.A., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Komaratih, E., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Airlangga University, Surabaya, Indonesia; Wildan, A., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Knoch, A.M.H., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia |
Since coronavirus disease 2019 was declared a global pandemic by the World Health Organization, it has become a challenging situation to continue medical education, including in Indonesia. The situation prohibited face-to-face (direct) educational activities in clinical settings, therefore also postponing examinations involving especially procedural skills. Adaptations were urgently needed to maintain the delivery of high-stake examinations to sustain the number of ophthalmology graduates and the continuation of eye health service. Objective structured clinical examination (OSCE) has been one of our widely used method to assess clinical competencies for ophthalmology residents, and is the one method that involves gatherings, close contact of examiners, examinees and patients, therefore the most difficult to adjust. Pandemic challenges brought technical changes in our delivering the OSCE to online, maximizing digital platforms of meetings, while still concerned to guarding the safety of candidates, patients and staffs. OSCE scenarios were also made as timely efficient as possible by changing continuous station models to a cascade one. The purpose of this article is to document our experience in conducting a feasible and reproducible OSCE in this pandemic era filled with limitations. © The Korean Society of Medical Education. All rights reserved. |
COVID-19; Education; Internship and residency; Methods; Ophthalmology / education |
clinical competence; education; health service; human; medical education; ophthalmology; Clinical Competence; COVID-19; Educational Measurement; Health Services; Humans; Internship and Residency; Ophthalmology; SARS-CoV-2 |
Korean Society of Medical Education |
2005727X |
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34875158 |
Article |
Q4 |
175 |
21057 |
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32 |
Yo E.C., Witjaksono A.N., Fitriani D.Y., Werdhani R.A., Parikesit D. |
57213188908;57224351398;57224589606;57189088848;57163830300; |
Evaluating knowledge retention and perceived benefits of medical webinar for professional development among Indonesian physicians |
2021 |
Korean Journal of Medical Education |
33 |
4 |
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381 |
391 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121761218&doi=10.3946%2fkjme.2021.206&partnerID=40&md5=88879a0b2b85137bc0337e9c3aa3de9b |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ophthalmology Medical Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, Depok, Indonesia; Occupational Medicine Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, Depok, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Urology Medical Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, Depok, Indonesia |
Yo, E.C., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Witjaksono, A.N., Ophthalmology Medical Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, Depok, Indonesia; Fitriani, D.Y., Occupational Medicine Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, Depok, Indonesia, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Werdhani, R.A., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Parikesit, D., Urology Medical Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, Depok, Indonesia |
Purpose: To assess knowledge retention of physicians after participating in a webinar series and its perceived benefits on daily practice and career development. Methods: The webinar series comprised six separate webinars about daily practice. Online questionnaires were sent to all participating physicians via email 3 months after the webinars. The questionnaire assessed knowledge retention through the difference between initial and follow-up post-test as well as the webinar series' benefits on daily practice and career development. Participants' demographic information, including their age, gender, education, year of graduation, and work details, were collected to compare outcomes between demographic groups. Results: A total of 689 responses were gathered, and 622 were analyzed. At follow-up, the median knowledge score was significantly lower than the initial median knowledge score (Z=-6.973, p<0.001). Participants' perception of the webinar series' benefits on daily practice and career development was very positive. A significant weak negative correlation was found between age and knowledge score at follow-up (rs=-0.157, p<0.001). Physicians who graduated more recently and worked for less than 3 years scored significantly higher on knowledge tests at follow-up. Meanwhile, perception score towards webinar series' benefits on daily practice was significantly higher among physicians with more extended work history. Male physicians scored significantly higher on perception score towards webinar series' benefits on career development. Conclusion: Online continuing medical education programs like webinars can encourage physicians to maintain their competence, but further research on improving knowledge retention over time is necessary. Overall, physicians perceived webinars to be beneficial for their professional development. © The Korean Society of Medical Education. All rights reserved. |
Continuing medical education; Knowledge retention; Physicians; Professional development; Videoconference |
human; Indonesia; male; medical education; physician; questionnaire; Education, Medical, Continuing; Humans; Indonesia; Male; Physicians; Surveys and Questionnaires |
Korean Society of Medical Education |
2005727X |
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34875154 |
Article |
Q4 |
175 |
21057 |
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363 |
Yo E.C., Witjaksono A.N., Fitriani D.Y., Werdhani R.A., Parikesit D. |
57213188908;57224351398;57224589606;57189088848;57163830300; |
Assessing webinar outcomes for health professionals: A perspective from Indonesia during coronavirus disease 2019 pandemic |
2021 |
Korean Journal of Medical Education |
33 |
2 |
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87 |
96 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107416703&doi=10.3946%2fKJME.2021.190&partnerID=40&md5=0cbaa0d20d5fdaa64a279a62d1943b06 |
Faculty of Medicine, Universitas Indonesia, Indonesia; Ophthalmology Medical Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, Indonesia; Occupational Medicine Staff Group, Universitas Indonesia Hospital, Universita Indonesia, Depok, Indonesia; Department of Community Medicine, Faculty of Medicine, Jakarta, Indonesia; Urology Medical Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, Depok, Indonesia; Universitas Indonesia Hospital, Pondok Cina, Beji, Depok City, West Java, 16424, Indonesia |
Yo, E.C., Faculty of Medicine, Universitas Indonesia, Indonesia; Witjaksono, A.N., Ophthalmology Medical Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, Indonesia; Fitriani, D.Y., Occupational Medicine Staff Group, Universitas Indonesia Hospital, Universita Indonesia, Depok, Indonesia, Department of Community Medicine, Faculty of Medicine, Jakarta, Indonesia; Werdhani, R.A., Department of Community Medicine, Faculty of Medicine, Jakarta, Indonesia, Universitas Indonesia Hospital, Pondok Cina, Beji, Depok City, West Java, 16424, Indonesia; Parikesit, D., Urology Medical Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, Depok, Indonesia |
Purpose: With the ongoing coronavirus disease 2019 (COVID-19) pandemic, health institutions and hospitals are increasingly relying on e-learning for continuing education. However, in many countries there is still limited data on the effectiveness of online learning particularly in the healthcare field. This study aims to evaluate whether webinar as a form of online educational intervention is satisfactory and effective for the continuing education of health professionals in Indonesia. Methods: We collected participants' demographic information including health profession, place of work, work unit, and year of graduation. There were six independent webinars included in this study. Webinar outcomes included satisfaction and learning scores. Regarding satisfaction, participants were told to complete a satisfaction survey and asked whether they would recommend the webinar to their colleagues. Regarding learning, information on their mean pre-test and post-test scores was collected. Results: A total of 3,607 health professionals were enrolled, with the highest participation in webinars about emergency cases and COVID-19 management. The response towards satisfaction was overwhelmingly positive. In all six webinars, post-test scores were statistically significantly higher than pre-test scores. Recently graduated physicians scored higher in learning than senior physicians, while place of work and work unit did not significantly affect the scores. Conclusion: The use of webinar for health professionals training in Indonesia was well-received amid the ongoing pandemic. In the future, health institutions and teaching hospitals should optimize the implementation of webinar training as it is associated with low cost, high flexibility, and less time commuting. © 2021 Korean Journal of Medical Education. All Rights Reserved. |
Continuing education; Covid-19; Health occupations; Online learning; Videoconferencing |
continuing education; cost benefit analysis; disease management; education; health care personnel; human; Indonesia; learning; pandemic; physician; procedures; satisfaction; teaching; teaching hospital; Cost-Benefit Analysis; COVID-19; Disease Management; Education, Continuing; Education, Distance; Educational Measurement; Health Personnel; Hospitals, Teaching; Humans; Indonesia; Learning; Pandemics; Personal Satisfaction; Physicians; SARS-CoV-2; Teaching |
Korean Society of Medical Education |
2005727X |
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34062640 |
Article |
Q4 |
175 |
21057 |
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863 |
Sahlan M., Tejamaya M., Arbianti R., Baruji T., Adawiyah R., Hermansyah H. |
57189182661;55295863200;55897945700;57222240819;57208658742;15759436800; |
The effects of nano-casein encapsulation and productions of a controlled-release on eugenol containing bio-pesticide toxicity |
2021 |
Key Engineering Materials |
874 KEM |
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115 |
127 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101971950&doi=10.4028%2fwww.scientific.net%2fKEM.874.115&partnerID=40&md5=6f6b175ce47bb2305dfbaffecf2240a3 |
Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia; Research Center of Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia; Department of Occupational Health and Safety, Faculty of Public Health, Universitas Indonesia, Depok, 16424, Indonesia; Center of Bioindustry Technology, Agency for The Assessment and Application of Technology, Jakarta, 10340, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Sahlan, M., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia, Research Center of Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia; Tejamaya, M., Department of Occupational Health and Safety, Faculty of Public Health, Universitas Indonesia, Depok, 16424, Indonesia; Arbianti, R., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia; Baruji, T., Center of Bioindustry Technology, Agency for The Assessment and Application of Technology, Jakarta, 10340, Indonesia; Adawiyah, R., Research Center of Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia, Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Hermansyah, H., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia |
The concern against long-term health and environmental adverse effects of synthetic pesticides has encouraged the development of bio-pesticides. Eugenol, a major constituent of clove oil, has been proven as potential bio-pesticides. However, evaporation and photosensitive properties of Eugenol needs to be controlled. Nano-encapsulation is a promising method that can preserve eugenol from evaporating and photodegradation. This study aims to investigate the production of a controlled-release of eugenol in casein micelle as well as the effects of nano-encapsulation on Eugenol Containing Biopesticide (ECB) toxicity against Artemia salina sp. Brine Shrimp Lethality Test (BSLT) was implemented to investigate effect of nano-encapsulation on ECB and the Response Surface Methodology was used to optimize the formula to investigate the production of a controlled-release of eugenol. The optimum condition revealed loading capacity and encapsulation efficiency response for 64.67% and 79.64%, respectively. The average diameter of the obtained nanocapsule-eugenol (NCE) was 179.83 nm. Release study was performed at 40 °C that represent as pesticide applied in farm, revealed that casein micelle capsule could delayed the release of eugenol. A cytotoxicity assay showed that the NCE has 21 times more effective compared with eugenol only. It was found that nano encapsulated ECB was statistically more toxic than ECBsuspension (without nano encapsulation) with a confidence level of 95%. Lethal Concentration 50 (LC50) of nano-ECB was 0.264 μg/L while LC50 of ECB-suspension was 4.445 μg/L. The increase of toxic properties after nano-encapsulation by casein could be explained by the increase of eugenol stability. Thus nano-encapsulation can be proposed as a method for improving the bio-pesticide ability of eugenol. © 2021 Trans Tech Publications Ltd, Switzerland. |
Biopesticide; BSLT1; Casein; Controlled-release; Eugenol; Nano encapsulation; Optimizing |
Casein; Dairies; Micelles; Suspensions (fluids); Toxicity; Brine shrimp lethalities; Cytotoxicity assays; Encapsulation efficiency; Investigate effects; Lethal concentration; Photosensitive properties; Response surface methodology; Synthetic pesticides; Pesticide effects |
Trans Tech Publications Ltd |
10139826 |
9783035737639 |
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Conference Paper |
Q4 |
175 |
21056 |
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No records
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205 |
Krisanti E.A., Gofara T.Z., Rahyussalim A.J., Mulia K. |
14019920500;57260804700;55212166100;6507666535; |
Polyvinyl alcohol (PVA)/chitosan/sodium tripolyphosphate (STPP) hydrogel formulation with freeze-thaw method for anti-tuberculosis drugs extended release |
2021 |
AIP Conference Proceedings |
2370 |
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020010 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115001335&doi=10.1063%2f5.0063175&partnerID=40&md5=a3c9afce6e9d9f6305976a87eb3a4790 |
Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia; Department of Orthopedic and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia |
Krisanti, E.A., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia; Gofara, T.Z., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia; Rahyussalim, A.J., Department of Orthopedic and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Mulia, K., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia |
Tuberculosis (TB) is one of the infectious diseases which must be routinely oral treated with anti-tuberculosis drugs performed 12-24 months. With treatment using drug implans that can release TB drugs in a longer time in the target location, it will be more effective, because the drug will be close to the target and go directly into the blood. In this study, the PVA / chitosan / STPP hydrogel formulation loaded with 4 types of anti-tuberculosis drugs (isoniazid, ethambutol, pirazinamide, and rifampicin) made using the freeze-thaw method. It is obtained that chitosan addition up until 20% could reduce drug's release rate and hold drug's release until 30 days, but the effect of STPP addition could not be seen because the ammount added is too small which is also shown from FTIR study that there is no STPP in the hydrogel detected. 80% PVA-20% Chitosan- 2% STPP hydrogel formulation release TB drugs the slowest and extended on Isoniazid, Ethambutol, and Rifampicin. SEM study shown that chitosan addition in PVA hydrogel resulted a homogen solution, and hydrogel with densely folded surface. 2% STPP addition resulted in smoother, more homogenous, and smaller pores morphology. © 2021 Author(s). |
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American Institute of Physics Inc. |
0094243X |
9780735441262 |
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Conference Paper |
- |
177 |
20880 |
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229 |
Nadhif M.H., Irsyad M., Rahyussalim A.J., Utomo M.S. |
57189057498;57220935587;55212166100;56180933900; |
Geometrical evaluation of CAM-configured thermoplastic polyurethane lattices for intervertebral disc replacements |
2021 |
AIP Conference Proceedings |
2382 |
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030006 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114011637&doi=10.1063%2f5.0060049&partnerID=40&md5=894c1cbce6bdc985a2b86b40dcf80e06 |
Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Department of Orthopedics and Traumatology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Central Hospital, Jakarta, 10430, Indonesia; Stem Cell and Tissue Engineering Cluster, Indonesia Medical Education and Research Institute (IMERI), Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Research Center for Metallurgy and Material, Indonesia Institute of Science (LIPI), Banten, 15310, Indonesia |
Nadhif, M.H., Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia, Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Irsyad, M., Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Rahyussalim, A.J., Department of Orthopedics and Traumatology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Central Hospital, Jakarta, 10430, Indonesia, Stem Cell and Tissue Engineering Cluster, Indonesia Medical Education and Research Institute (IMERI), Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Utomo, M.S., Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia, Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia, Research Center for Metallurgy and Material, Indonesia Institute of Science (LIPI), Banten, 15310, Indonesia |
Intervertebral discs (IVD) are prone to deformation due to higher stress that the discs can endure. Treatments for deformed IVDs include total disc replacements. Some studies concluded the superiority of spinal fusion compared to total disc replacement devices, either in the lumbar or cervical region. In current study, cuboid scaffolds made of thermoplastic polyurethane with lattice architecture were designed and configured using computer-aided manufacturing (CAM). The scaffolds were fabricated using fused filament fabrication. Process parameters were characterized and optimized to obtain scaffolds with uniform cells distribution. The struts at the top surface had average width values closer to the setpoints than the struts at the bottom surface, indicated by lower RMSE values for the struts at the top surface. However, the printing consistency in the same extrusion ratio at the bottom surface was higher than at the top surface, indicated by lower standard deviation values. Statistical analysis using standard deviation, RMSE, and Tukey's test showed that current scaffolds had non-uniform distribution between layers, which required further improvement. © 2021 Author(s). |
Computer-aided manufacturing; intervertebral disc; lattice structure; polyurethane |
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American Institute of Physics Inc. |
0094243X |
9780735441156 |
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Conference Paper |
- |
177 |
20880 |
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392 |
Hardiany N.S., Amaanullah M.Z.B., Antarianto R.D. |
57192910605;57224223597;57190862806; |
The effect of fasting on malondialdehyde level in liver and plasma of New Zealand white rabbits |
2021 |
AIP Conference Proceedings |
2353 |
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030093 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107282294&doi=10.1063%2f5.0052627&partnerID=40&md5=f1091bc64391ab80b12474af251808e8 |
Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Indonesia; Center of Hypoxia and Oxidative Stress Studies, Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia, Indonesia; Faculty of Medicine Universitas Indonesia, Indonesia; Departemnet of Histology, Faculty of Medicine Universitas Indonesia, Indonesia |
Hardiany, N.S., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Indonesia, Center of Hypoxia and Oxidative Stress Studies, Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia, Indonesia; Amaanullah, M.Z.B., Faculty of Medicine Universitas Indonesia, Indonesia; Antarianto, R.D., Departemnet of Histology, Faculty of Medicine Universitas Indonesia, Indonesia |
Oxidative stress is a state of imbalance of free radicals in the cells and is one of the causes of various diseases in humans. One method that is thought to reduce oxidative stress is calorie restriction or fasting. However, its effects remain unclear. This study was conducted to determine the effect of intermittent fasting and prolonged fasting on the levels of malondialdehyde (MDA) as an oxidative stress marker in the liver and plasma of New Zealand White rabbits. Fifteen of New Zealand White rabbits were divided into three groups (intermittent fasting (IF), prolonged fasting (PF), and control). MDA was measured in plasma and liver homogenate using spectrophotometry. The results were analyzed using One-way ANOVA test. The liver MDA level was decreased in the IF group, but not significant. However, there was a significant increase in plasma MDA levels both in the IF and PF groups. Moreover, liver MDA level was increased in PF group, although it was not significant. In conclusion, intermittent and prolonged fasting could increase plasma MDA levels significantly. © 2021 Author(s). |
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American Institute of Physics Inc. |
0094243X |
9780735440968 |
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Conference Paper |
- |
177 |
20880 |
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393 |
Yusra Y., Widjaja L., Witjaksono F., Timan I.S., Kumalawati J., Adiyanti S.S., Nurbaya S., Immanuel S. |
57220998367;56906852200;57070455800;6602793366;6504406695;57191952811;57225297244;12777341300; |
Amino acid profile in patients of chronic kidney disease on hemodialysis in Indonesia |
2021 |
AIP Conference Proceedings |
2353 |
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030014 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107266850&doi=10.1063%2f5.0052847&partnerID=40&md5=ca448315d7144ead78ebf8040fae2eb4 |
Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia |
Yusra, Y., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Widjaja, L., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Witjaksono, F., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Timan, I.S., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Kumalawati, J., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Adiyanti, S.S., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Nurbaya, S., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Immanuel, S., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia |
Protein energy wasting (PEW) is a nutritional disorder syndrome that occurs 28-80% in chronic kidney disease (CKD) patients on hemodialysis. Hemodialysis cause the nutrients loss including amino acids, increase protein catabolism induced by inflammation, and inhibit protein synthesis. The objective of this study was to acquire the amino acid profile in CKD patients on hemodialysis. This study used cross sectional design and involving 60 subjects of CKD patients aged >18 years on routine hemodialysis at Dr. Cipto Mangunkusumo National Referral Hospital. Amino acids examination was using dried blood spots (DBSs) sample and Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) method. We examined 10 non-essential (alanine, arginine, aspartic acid, glutamic acid, asparagine, glycine, glutamine, proline, serine, tyrosine), 9 essentials (histidine, phenylalanine, isoleucine, leucine, lysine, methionine, threonine, tryptophan, valine), and 2 special (ornithine, citrulline) amino acids. The results showed that almost all amino acids were lower (6 non-essential, 8 essentials, and citrulline), whereas others were higher (aspartate acid, serine) or normal (glutamic acid, glycine, methionine, and ornithine) than normal reference value from Mayo. CKD patients on hemodialysis have decreased amino acid especially essential amino acids. These results can be used in modification of amino acid supplementation CKD patient on hemodialysis in Indonesia. © 2021 Author(s). |
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American Institute of Physics Inc. |
0094243X |
9780735440968 |
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Conference Paper |
- |
177 |
20880 |
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434 |
Pustimbara A., Putri D.C., Prakoso N.M., Priambodo R., Ariani Y., Yuliarti K., Bowolaksono A., Sjarif D.R. |
57217086984;57204606877;57214084050;57190937999;57200504713;54917483500;57205093224;6506242684; |
Novel base alterations at intron 3 of 6-pyruvoyl-tetrahydropterin synthase gene in Indonesian population |
2021 |
AIP Conference Proceedings |
2331 |
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050028 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103860378&doi=10.1063%2f5.0042047&partnerID=40&md5=80d1cbd9c9334c733fed5caccbb5bdad |
Human Genetics Research Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Pediatric, Universitas Indonesia, RSUPN, Dr. Cipto Mangunkusumo, Jakarta, 10430, Indonesia; Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, Indonesia |
Pustimbara, A., Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, Indonesia; Putri, D.C., Human Genetics Research Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, Indonesia; Prakoso, N.M., Human Genetics Research Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, 10430, Indonesia; Priambodo, R., Human Genetics Research Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, 10430, Indonesia; Ariani, Y., Human Genetics Research Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Pediatric, Universitas Indonesia, RSUPN, Dr. Cipto Mangunkusumo, Jakarta, 10430, Indonesia, Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Yuliarti, K., Human Genetics Research Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Pediatric, Universitas Indonesia, RSUPN, Dr. Cipto Mangunkusumo, Jakarta, 10430, Indonesia; Bowolaksono, A., Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, Indonesia; Sjarif, D.R., Human Genetics Research Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Pediatric, Universitas Indonesia, RSUPN, Dr. Cipto Mangunkusumo, Jakarta, 10430, Indonesia |
6-pyruvoyl-tetrahydropterin synthase (PTPS) or tetrahydrobiopterin (BH4) deficiency is the most common enzyme synthesis defect which was reported to cause of hyperphenylalaninemia. This deficiency is caused by pathogenic variant in exons and introns of 6-pyruvoyl-tetrahydropterin synthase (PTS) gene in chromosome 11q22.3-q23.3. This study is focused on the detection of DNA variants in intron 3 especially for insertion and base alteration. Methods that has been carried out in this study are DNA isolation, polymerase chain reaction (PCR), the visualization of PCR products through DNA electrophoresis, and Sanger sequencing. A total 29 variants have been characterized in this study, obtained from the DNA of one Indonesian PTPS patients and 33 healthy individuals as control. Those alterations were categorized into substitution and intronic insertion and located in the sequence of intron 3 and 4 of PTS gene. Further analyses are required to be performed to characterize the effect of identified variants to the splicing events of PTS mRNA. © 2021 Author(s). |
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American Institute of Physics Inc. |
0094243X |
9780735440753 |
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Conference Paper |
- |
177 |
20880 |
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435 |
Widyaningrum A.R., Prakoso N.M., Priambodo R., Aswin Y.A., Hafifah C.N., Sjarif D.R. |
57211929162;57214084050;57190937999;57222721787;57204112129;6506242684; |
Identification of novel mutations in exon 1 of iduronate-2-sulfatase gene from mucopolysaccharidosis type II patient in Indonesia |
2021 |
AIP Conference Proceedings |
2331 |
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050026 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103846997&doi=10.1063%2f5.0042045&partnerID=40&md5=23bc8c1777e9bfa31dccebb034820f8e |
Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, Indonesia; Human Genetics Research Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Pediatric, Universitas Indonesia, RSUPN, Dr. Cipto Mangunkusumo, Jakarta, 10430, Indonesia; Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia |
Widyaningrum, A.R., Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, Indonesia; Prakoso, N.M., Human Genetics Research Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, 10430, Indonesia; Priambodo, R., Department of Pediatric, Universitas Indonesia, RSUPN, Dr. Cipto Mangunkusumo, Jakarta, 10430, Indonesia; Aswin, Y.A., Department of Pediatric, Universitas Indonesia, RSUPN, Dr. Cipto Mangunkusumo, Jakarta, 10430, Indonesia, Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Hafifah, C.N., Human Genetics Research Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Pediatric, Universitas Indonesia, RSUPN, Dr. Cipto Mangunkusumo, Jakarta, 10430, Indonesia; Sjarif, D.R., Human Genetics Research Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Pediatric, Universitas Indonesia, RSUPN, Dr. Cipto Mangunkusumo, Jakarta, 10430, Indonesia |
Mucopolysaccharidosis type II (MPS II, OMIM 309900) is an X-linked recessive lysosomal storage disorder caused by the accumulation of heparan sulfate and dermatan sulfate due to iduronate-2-sulfatase (IDS) enzyme deficiency. To detect IDS gene mutation, DNA samples are obtained from 10 MPS II patients and 50 normal individuals, then the exon 1 of IDS gene was analyzed with Sanger sequencing. Two novel mutations are found from one male patient at the site of c.22C>A (p.Arg8=) and c.54C>A (p.Ser18Arg). Both mutations are not located in the bases which are responsible as the signal peptide cleavage site. Amino acid substitution c.54C>A (p.Ser18Arg) does not change the hydrophobic characteristic as both amino acids are hydrophobic. Therefore, those mutations do not change IDS enzyme structure nor alter the signaling pathway of IDS mRNA-ribosome complex to the endoplasmic reticulum. This study of exon 1 is the first to be performed in Indonesia. The novel mutations found in this study can contribute to a single nucleotide polymorphism (SNP) database of MPS II patients from all over the world, thus it leads to a deeper understanding of this rare disease at the molecular level. Therefore, a genotype study is needed to get a full profile of MPS II patients in Indonesia. © 2021 Author(s). |
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American Institute of Physics Inc. |
0094243X |
9780735440753 |
|
Conference Paper |
- |
177 |
20880 |
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