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33 |
Umbarawan Y., Kawakami R., Syamsunarno M.R.A.A., Obinata H., Yamaguchi A., Hanaoka H., Hishiki T., Hayakawa N., Koitabashi N., Sunaga H., Matsui H., Kurabayashi M., Iso T. |
57196077830;57210447153;36142388300;6506181723;23394341400;56020036100;7004072867;57221461061;6603109711;55061468300;57212330485;7103371684;7003498756; |
Reduced fatty acid use from cd36 deficiency deteriorates streptozotocin-induced diabetic cardiomyopathy in mice |
2021 |
Metabolites |
11 |
12 |
881 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121605641&doi=10.3390%2fmetabo11120881&partnerID=40&md5=50b9a38996d07912da5741dbe717f2f0 |
Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya no. 6, Jakarta, 10430, Indonesia; Department of Biomedical Sciences, Universitas Padjadjaran, Jl. Raya Bandung Sumedang KM 21, Jatinangor, 45363, Indonesia; Education and Research Support Center, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Department of Bioimaging Information Analysis, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Department of Biochemistry, Keio University School of Medicine, 35 Shinano-Machi, Shinjuku-Ku, Tokyo, 160-8582, Japan; Clinical and Translational Research Center, Keio University School of Medicine, 35 Shinano-Machi, Shinjuku-Ku, Tokyo, 160-8582, Japan; Center for Liberal Arts and Sciences, Ashikaga University, 268-1 Omae-Machi, Ashikaga, 326-8558, Japan; Department of Laboratory Sciences, Gunma University Graduate School of Health Sciences, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Department of Medical Technology and Clinical Engineering, Gunma University of Health and Welfare, 191-1 Kawamagari-Machi, Maebashi, 371-0823, Japan |
Umbarawan, Y., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya no. 6, Jakarta, 10430, Indonesia; Kawakami, R., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Syamsunarno, M.R.A.A., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan, Department of Biomedical Sciences, Universitas Padjadjaran, Jl. Raya Bandung Sumedang KM 21, Jatinangor, 45363, Indonesia; Obinata, H., Education and Research Support Center, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Yamaguchi, A., Department of Bioimaging Information Analysis, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Hanaoka, H., Department of Bioimaging Information Analysis, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Hishiki, T., Department of Biochemistry, Keio University School of Medicine, 35 Shinano-Machi, Shinjuku-Ku, Tokyo, 160-8582, Japan, Clinical and Translational Research Center, Keio University School of Medicine, 35 Shinano-Machi, Shinjuku-Ku, Tokyo, 160-8582, Japan; Hayakawa, N., Department of Biochemistry, Keio University School of Medicine, 35 Shinano-Machi, Shinjuku-Ku, Tokyo, 160-8582, Japan, Clinical and Translational Research Center, Keio University School of Medicine, 35 Shinano-Machi, Shinjuku-Ku, Tokyo, 160-8582, Japan; Koitabashi, N., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Sunaga, H., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan, Center for Liberal Arts and Sciences, Ashikaga University, 268-1 Omae-Machi, Ashikaga, 326-8558, Japan; Matsui, H., Department of Laboratory Sciences, Gunma University Graduate School of Health Sciences, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Kurabayashi, M., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Iso, T., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan, Department of Medical Technology and Clinical Engineering, Gunma University of Health and Welfare, 191-1 Kawamagari-Machi, Maebashi, 371-0823, Japan |
Cardiac dysfunction is induced by multifactorial mechanisms in diabetes. Deranged fatty acid (FA) utilization, known as lipotoxicity, has long been postulated as one of the upstream events in the development of diabetic cardiomyopathy. CD36, a transmembrane glycoprotein, plays a major role in FA uptake in the heart. CD36 knockout (CD36KO) hearts exhibit reduced rates of FA transport with marked enhancement of glucose use. In this study, we explore whether reduced FA use by CD36 ablation suppresses the development of streptozotocin (STZ)-induced diabetic cardiomyopathy. We found that cardiac contractile dysfunction had deteriorated 16 weeks after STZ treatment in CD36KO mice. Although accelerated glucose uptake was not reduced in CD36KO-STZ hearts, the total energy supply, estimated by the pool size in the TCA cycle, was significantly reduced. The isotopomer analysis with13 C6-glucose revealed that accelerated glycolysis, estimated by enrichment of13 C2-citrate and13 C2-malate, was markedly suppressed in CD36KO-STZ hearts. Levels of ceramides, which are cardiotoxic lipids, were not elevated in CD36KO-STZ hearts compared to wild-type-STZ ones. Furthermore, increased energy demand by transverse aortic constriction resulted in synergistic exacerbation of contractile dysfunction in CD36KO-STZ mice. These findings suggest that CD36KO-STZ hearts are energetically compromised by reduced FA use and suppressed glycolysis; therefore, the limitation of FA utilization is detrimental to cardiac energetics in this model of diabetic cardiomyopathy. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
CD36; Ceramide; Diabetic cardiomyopathy; Fatty acid; Glucose; Metabolomics; Streptozotocin |
CD36 antigen; fatty acid; fluorodeoxyglucose f 18; formaldehyde; glucose; glycogen; insulin; isoflurane; liquid nitrogen; streptozocin; triacylglycerol; animal cell; animal experiment; animal model; animal tissue; aortic constriction; Article; biochemical analysis; capillary electrophoresis; centrifugation; citric acid cycle; controlled study; diabetes mellitus; diabetic cardiomyopathy; energy resource; enzyme linked immunosorbent assay; fatty acid blood level; fatty acid transport; fibrosis; genotype; glucose blood level; glucose transport; glycogen level; heart disease; heart function; heart rate; hemodynamics; knockout gene; knockout mouse; lactate blood level; liquid chromatography-mass spectrometry; male; mass spectrometry; Masson trichrome stain; metabolic fingerprinting; metabolome; |
MDPI |
22181989 |
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Article |
Q2 |
1109 |
3744 |
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38 |
Dhelika R., Hadi A.F., Yusuf P.A. |
55536628000;57368046500;57192156597; |
Development of a motorized hospital bed with swerve drive modules for holonomic mobility |
2021 |
Applied Sciences (Switzerland) |
11 |
23 |
1356 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120877522&doi=10.3390%2fapp112311356&partnerID=40&md5=7c16eb6fe630116772c69c4d02b4bd9f |
Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI, Depok, 16424, Indonesia; Department of Medical Physics/Medical Technology Core Cluster IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Dhelika, R., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI, Depok, 16424, Indonesia; Hadi, A.F., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI, Depok, 16424, Indonesia; Yusuf, P.A., Department of Medical Physics/Medical Technology Core Cluster IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
In hospitals; transferring patients using hospital beds is time consuming and inefficient. Additionally; the task of frequently pushing and pulling beds poses physical injury risks to nurses and caregivers. Motorized hospital beds with holonomic mobility have been previously proposed. However; most such beds come with complex drivetrain which makes them costly and hinders largerāscale adoption in hospitals. In this study; a motorized hospital bed that utilizes a swerve drive mechanism is proposed. The design takes into account simplicity which would allow for minimum modification of the existing beds. Two DC motors for steering and propulsion are used for a single swerve drive module. The control of the propulsion motor is achieved by a combination of trajectory planning based on quintic polynomials and PID control. Further; the control performance of the proposed bed was evaluated; and the holonomic mobility of its prototype was successfully demonstrated. An average error of less than 3% was obtained for motion with a constant velocity; however; larger values in the range of 15% were observed for other conditions, such as accelerating and decelerating. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Hospital bed; Mechatronics; PID control; Swerve drive; Trajectory planning |
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MDPI |
20763417 |
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Article |
Q2 |
435 |
11324 |
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49 |
Al-Jawadi A.A., Priliani L., Oktavianthi S., Febinia C.A., Daya M., Artika I.M., Malik S.G. |
57327931000;57203360168;38361976900;55195897900;57208032155;57194561825;7402973374; |
Association of FTO rs1421085 single nucleotide polymorphism with fat and fatty acid intake in Indonesian adults |
2021 |
BMC Research Notes |
14 |
1 |
411 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118749881&doi=10.1186%2fs13104-021-05823-1&partnerID=40&md5=c2e5f8f0c5b077d184062624f315d2dc |
Department of Biochemistry, Faculty of Mathematics and Natural Sciences, Bogor Agricultural University, Kampus IPB Dramaga, Jl. Raya Dramaga, Bogor, West Java 16680, Indonesia; Eijkman Institute for Molecular Biology, Ministry of Research and Technology/National Research and Innovation Agency, Jl. Diponegoro No. 69, Jakarta, 10430, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Al-Jawadi, A.A., Department of Biochemistry, Faculty of Mathematics and Natural Sciences, Bogor Agricultural University, Kampus IPB Dramaga, Jl. Raya Dramaga, Bogor, West Java 16680, Indonesia; Priliani, L., Eijkman Institute for Molecular Biology, Ministry of Research and Technology/National Research and Innovation Agency, Jl. Diponegoro No. 69, Jakarta, 10430, Indonesia; Oktavianthi, S., Eijkman Institute for Molecular Biology, Ministry of Research and Technology/National Research and Innovation Agency, Jl. Diponegoro No. 69, Jakarta, 10430, Indonesia; Febinia, C.A., Eijkman Institute for Molecular Biology, Ministry of Research and Technology/National Research and Innovation Agency, Jl. Diponegoro No. 69, Jakarta, 10430, Indonesia; Daya, M., Department of Nutrition, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Artika, I.M., Department of Biochemistry, Faculty of Mathematics and Natural Sciences, Bogor Agricultural University, Kampus IPB Dramaga, Jl. Raya Dramaga, Bogor, West Java 16680, Indonesia, Eijkman Institute for Molecular Biology, Ministry of Research and Technology/National Research and Innovation Agency, Jl. Diponegoro No. 69, Jakarta, 10430, Indonesia; Malik, S.G., Eijkman Institute for Molecular Biology, Ministry of Research and Technology/National Research and Innovation Agency, Jl. Diponegoro No. 69, Jakarta, 10430, Indonesia |
Objective: Recent studies showed that genetic polymorphisms in the fat mass and obesity-associated gene (FTO) were associated with obesity and dietary intake. In this study of 71 adults in Jakarta, Indonesia, we investigated FTO rs1421085 association with body mass index (BMI), macronutrient intake, and fatty acid intake. The association was evaluated using linear regression analyses assuming co-dominant, dominant, recessive, over-dominant, and additive genetic models. Results: Only individuals with the CC genotype had a considerably higher BMI (p < 0.001), which indicates a recessive genetic trait, but the incidence for this genotype is low (68 TT + TC vs. 3 CC). Individuals with the minor C allele had an estimated increase of fat intake by 3.45–4.06% across various genetic models (dominant: p < 0.010, over-dominant: p < 0.030, additive: p < 0.010). Subjects with TC/CC genotypes had increased dietary monounsaturated fatty acid (MUFA; 1.14%, p = 0.046) and saturated fatty acid (SAFA; 2.06%, p = 0.023) intakes, compared to those with the TT genotype. In conclusion, our study provided evidence for the association between FTO rs1421085 risk allele with higher BMI and individual preferences for consuming more fat, MUFA, and SAFA. This study highlights the important role of FTO gene in food preference, and its influence on body weight. © 2021, The Author(s). |
Fat intake; Fatty acid; FTO; Indonesia; Obesity; rs1421085 |
alpha ketoglutarate dependent dioxygenase FTO; fatty acid; FTO protein, human; adult; body mass; genetic predisposition; genetics; genotype; human; Indonesia; single nucleotide polymorphism; Adult; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Body Mass Index; Fatty Acids; Genetic Predisposition to Disease; Genotype; Humans; Indonesia; Polymorphism, Single Nucleotide |
BioMed Central Ltd |
17560500 |
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34743743 |
Article |
Q2 |
608 |
8303 |
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51 |
Viswanathan S., Hiew F.L., Siritho S., Apiwattanakul M., Tan K., Quek A.M.L., Estiasari R., Remli R., Bhaskar S., Islam B.M., Aye S.M.M., Ohnmar O., Umapathi T., Keosodsay S.S., Hoang N.T.T., Yeo T., Pasco P.M. |
56372225400;56520422700;15519966800;57195288799;37032197900;13605538000;55240204000;6504090091;57226417398;57194464797;55644071900;57201460031;6602092493;57201460833;57310352700;57310352800;6506559205; |
Impact of Covid-19 on the therapeutic plasma exchange service within the South East Asian region: Consensus recommendations and global perspectives |
2021 |
Journal of Clinical Apheresis |
36 |
6 |
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849 |
863 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117763064&doi=10.1002%2fjca.21937&partnerID=40&md5=3fb4e2326e829716a437226b18f33390 |
Department of Neurology, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia; Department of Neurology, Bumrungrad International Hospital and Siriraj Hospital, Mahidol University, Bangkok, Thailand; Department of Neurology, Neurological Institute of Thailand, Bangkok, Thailand; Department of Neurology, National Neuroscience Institute, Singapore; Division of Neurology, Department of Medicine, National University Health System, Singapore; Department of Neurology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Neurology, National University of Malaysia, Kuala Lumpur, Malaysia; Department of Medicine, Universiti Teknologi MARA, Sg Buloh, Selangor, Malaysia; Department of Laboratory Sciences and Services Division, The International Center for Diarrhoeal Disease Research, Dhaka, Bangladesh; Department of Neurology, Aryu International Hospital, Yangon, Myanmar; Department of Neurology, Yangon General Hospital, Yangon, Myanmar; Department of Neurology, Laos General Hospital, Vientiane, Laos; Department of Neurology, Military Hospital 175, Ho Chi Minh City, Viet Nam; Department of Neurosciences, Philippine General Hospital, Manila, Philippines |
Viswanathan, S., Department of Neurology, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia; Hiew, F.L., Department of Neurology, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia; Siritho, S., Department of Neurology, Bumrungrad International Hospital and Siriraj Hospital, Mahidol University, Bangkok, Thailand; Apiwattanakul, M., Department of Neurology, Neurological Institute of Thailand, Bangkok, Thailand; Tan, K., Department of Neurology, National Neuroscience Institute, Singapore; Quek, A.M.L., Division of Neurology, Department of Medicine, National University Health System, Singapore; Estiasari, R., Department of Neurology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Remli, R., Department of Neurology, National University of Malaysia, Kuala Lumpur, Malaysia; Bhaskar, S., Department of Medicine, Universiti Teknologi MARA, Sg Buloh, Selangor, Malaysia; Islam, B.M., Department of Laboratory Sciences and Services Division, The International Center for Diarrhoeal Disease Research, Dhaka, Bangladesh; Aye, S.M.M., Department of Neurology, Aryu International Hospital, Yangon, Myanmar; Ohnmar, O., Department of Neurology, Yangon General Hospital, Yangon, Myanmar; Umapathi, T., Department of Neurology, National Neuroscience Institute, Singapore; Keosodsay, S.S., Department of Neurology, Laos General Hospital, Vientiane, Laos; Hoang, N.T.T., Department of Neurology, Military Hospital 175, Ho Chi Minh City, Viet Nam; Yeo, T., Department of Neurology, National Neuroscience Institute, Singapore; Pasco, P.M., Department of Neurosciences, Philippine General Hospital, Manila, Philippines |
Introduction: Therapeutic plasma exchange (TPE) for neuroimmunological disorders has played an increasingly important role within the Southeast Asian (SEA) region. The South East Asian Therapeutic Plasma exchange Consortium (SEATPEC) was formed in 2018 to promote education and research on TPE within the region. The advent of the Covid-19 pandemic has produced challenges for the development and expansion of this service. Methodology: A qualitative and semi-quantitative questionnaire-based survey was conducted by SEATPEC member countries from January to June 2020 (Phase 1) and then from July 2020 to January 2021 in (Phase 2) to assess the impact of Covid-19 on regional TPE. Objectives: The study's main objectives were to explore the challenges experienced and adaptations/adjustments taken by SEATPEC countries in order to continue safe and efficient TPE during the Covid-19 pandemic. Results: The pandemic was found to disrupt the delivery of TPE services in all SEATPEC countries. Contributing factors were multifactorial due to overstretched medical services, staff shortages, quarantines and redeployments, fear of acquiring Covid-19, movement restriction orders, and patient's psychological fear of attending hospitals/testing for Covid-19. All SEATPEC countries practiced careful stratification of cases for TPE (electives vs emergencies, Covid-19 vs non-Covid-19 cases). SEATPEC countries had to modify TPE treatment protocols to include careful preprocedure screening of patient's for Covid-19, use of personal protective equipment (PPE) and post-TPE sanitization of machines and TPE suites. Conclusion: Based on the responses of the survey, SEATPEC countries produced a consensus statement with five recommendations for safe and effective TPE within the region. © 2021 Wiley Periodicals LLC. |
Covid-19; impact; South East Asia; therapeutic plasma exchange |
complication; consensus; epidemiology; human; neurologic disease; neurologist; pandemic; plasma exchange; procedures; questionnaire; Southeast Asia; Asia, Southeastern; Consensus; COVID-19; Humans; Nervous System Diseases; Neurologists; Pandemics; Plasma Exchange; SARS-CoV-2; Surveys and Questionnaires |
John Wiley and Sons Inc |
07332459 |
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34694652 |
Article |
Q2 |
697 |
7146 |
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52 |
Nababan S.H.H., Mansjoer A., Fauzi A., Gani R.A. |
57205443199;24335647800;36518523000;23495930300; |
Predictive scoring systems for in-hospital mortality due to acutely decompensated liver cirrhosis in Indonesia |
2021 |
BMC Gastroenterology |
21 |
1 |
392 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117564939&doi=10.1186%2fs12876-021-01972-6&partnerID=40&md5=8028251c29a052e830e58ba7b4786ff1 |
Hepatobiliary Division, Internal Medicine Department, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia; Clinical Epidemiology Unit, Internal Medicine Department, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Diponegoro No.71, Jakarta, 10430, Indonesia; Gastroenterology Division, Internal Medicine Department, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Diponegoro No.71, Jakarta, 10430, Indonesia |
Nababan, S.H.H., Hepatobiliary Division, Internal Medicine Department, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia; Mansjoer, A., Clinical Epidemiology Unit, Internal Medicine Department, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Diponegoro No.71, Jakarta, 10430, Indonesia; Fauzi, A., Gastroenterology Division, Internal Medicine Department, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Diponegoro No.71, Jakarta, 10430, Indonesia; Gani, R.A., Hepatobiliary Division, Internal Medicine Department, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia |
Background: Acutely decompensated liver cirrhosis is associated with high medical costs and negatively affects productivity and quality of life. Data on factors associated with in-hospital mortality due to acutely decompensated liver cirrhosis in Indonesia are scarce. This study aims to identify predictors of in-hospital mortality and develop predictive scoring systems for clinical application in acutely decompensated liver cirrhosis patients. Methods: This was a retrospective cohort study using a hospital database of acutely decompensated liver cirrhosis data at Cipto Mangunkusumo National General Hospital, Jakarta (2016–2019). Bivariate and multivariate logistic regression analyses were performed to identify the predictors of in-hospital mortality. Two scoring systems were developed based on the identified predictors. Results: A total of 241 patients were analysed; patients were predominantly male (74.3%), had hepatitis B (38.6%), and had Child–Pugh class B or C cirrhosis (40% and 38%, respectively). Gastrointestinal bleeding was observed in 171 patients (70.9%), and 29 patients (12.03%) died during hospitalization. The independent predictors of in-hospital mortality were age (adjusted OR: 1.09 [1.03–1.14]; p = 0.001), bacterial infection (adjusted OR: 6.25 [2.31–16.92]; p < 0.001), total bilirubin level (adjusted OR: 3.01 [1.85–4.89]; p < 0.001) and creatinine level (adjusted OR: 2.70 [1.20–6.05]; p = 0.016). The logistic and additive scoring systems, which were developed based on the identified predictors, had AUROC values of 0.899 and 0.868, respectively. Conclusion: The in-hospital mortality rate of acutely decompensated liver cirrhosis in Indonesia is high. We have developed two predictive scoring systems for in-hospital mortality in acutely decompensated liver cirrhosis patients. © 2021, The Author(s). |
Acute decompensation; In-hospital mortality; Liver cirrhosis; Prognosis; Scoring system |
epidemiology; hospital mortality; human; Indonesia; liver cirrhosis; male; prognosis; quality of life; retrospective study; Hospital Mortality; Humans; Indonesia; Liver Cirrhosis; Male; Prognosis; Quality of Life; Retrospective Studies |
BioMed Central Ltd |
1471230X |
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34670501 |
Article |
Q2 |
935 |
4832 |
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58 |
Nugraha R.R., Miranda A.V., Ahmadi A., Lucero-Prisno D.E., III |
57264816700;57222664687;57219362523;56051373800; |
Accelerating Indonesian COVID-19 vaccination rollout: a critical task amid the second wave |
2021 |
Tropical Medicine and Health |
49 |
1 |
76 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115262837&doi=10.1186%2fs41182-021-00367-3&partnerID=40&md5=4ba56c15796323e2ec17398a40768955 |
USAID Health Financing Activity/ThinkWell, Jakarta, Indonesia; Faculty of Medicine, University of Indonesia, Depok, West Java, Indonesia; Medical Research Center, Kateb University, Kabul, Afghanistan; Department of Public Health, International School of Medicine, Bishkek, Kyrgyzstan; Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, United Kingdom; Faculty of Management and Development Studies, University of the Philippines (Open University), Los Baños, Laguna, Philippines |
Nugraha, R.R., USAID Health Financing Activity/ThinkWell, Jakarta, Indonesia; Miranda, A.V., Faculty of Medicine, University of Indonesia, Depok, West Java, Indonesia; Ahmadi, A., Medical Research Center, Kateb University, Kabul, Afghanistan, Department of Public Health, International School of Medicine, Bishkek, Kyrgyzstan; Lucero-Prisno, D.E., III, Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, United Kingdom, Faculty of Management and Development Studies, University of the Philippines (Open University), Los Baños, Laguna, Philippines |
Coronavirus disease-19 (COVID-19) has been spreading in every part of the world, putting nations at risk with its pandemic status, including Indonesia. COVID-19 vaccine has been deemed as one of the most effective interventions to date for mitigating the spread and mortality from COVID-19. Responding to the situation, the Government of Indonesia (GOI) has allocated the means necessary to procure and distribute COVID-19 vaccines; placing into consideration the unique context of the country, recently categorized as a middle-income country and archipelagic with a population over 270 million. This article aims to present the challenges associated with the distribution of COVID-19 vaccination as well as recommendations to mitigate them, to ensure a timely and effective COVID-19 vaccination program in Indonesia. © 2021, The Author(s). |
COVID-19; Indonesia; Pandemic; Recommendations; Second wave; Vaccination |
SARS-CoV-2 vaccine; anti-vaccination movement; coronavirus disease 2019; cryopreservation; decentralization; diplomacy; drug shortage; drug storage; funding; government; human; Indonesia; Letter; pandemic; social responsibility; vaccination; vaccination coverage; vaccine production |
BioMed Central Ltd |
13488945 |
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Letter |
Q2 |
830 |
5753 |
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61 |
Sukrisman L. |
8661764000; |
Soluble P-selectin and correlation with Prothrombin Fragment 1 + 2 in myeloid malignancies in Cipto Mangunkusumo general hospital |
2021 |
Thrombosis Journal |
19 |
1 |
51 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111667161&doi=10.1186%2fs12959-021-00307-5&partnerID=40&md5=29949e22d24b9e6bcdb419fb321d6664 |
Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Sukrisman, L., Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Background: Myeloid cells express microparticles that could increase the expression of adhesion molecules including P-selectin. We aimed to evaluate the level of soluble P-selectin (sP-selectin) and prothrombin fragment 1 + 2 (F1 + 2), and to determine correlation of sP-selectin with leukocyte count and F1 + 2 levels in acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) patients. Methods: Patients with newly diagnosed AML (n = 25), CML (n = 13), and controls (n = 17) were recruited in this study. The diagnosis of AML and CML is based on 2001 WHO and/or FAB criteria. Levels of sP-selectin and F1 + 2 were determined using enzyme-linked immunosorbent assay kits (Behring ELISA Processor-III® and Behring Enzygnost F1 + 2). Results: sP-selectin was significantly elevated in CML patients compared to AML patients (p = 0.001). Levels of F1 + 2 in AML and CML patients were significantly increased in comparison to controls (p < 0.001 and p = 0.043). Levels of sP-selectin were significantly correlated to leukocyte count (r = 0.437; p = 0.029) and F1 + 2 (r = 0.436; p = 0.029) in AML patients. Conclusions: AML and CML patients had an increased tendency to thrombosis. While CML patients had higher platelet and/or endothelial activation, hypercoagulable state are more pronounced in AML patients. © 2021, The Author(s). |
AML; CML; F1 + 2; sP-selectin |
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BioMed Central Ltd |
14779560 |
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Article |
Q2 |
1004 |
4364 |
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64 |
Syam A.F., Waskito L.A., Rezkitha Y.A.A., Simamora R.M., Yusuf F., Danchi K.E., Bakry A.F., Arnelis, Mulya E., Siregar G.A., Sugihartono T., Maulahela H., Doohan D., Miftahussurur M., Yamaoka Y. |
8443384400;57192177367;56543533600;57224324158;57192179254;57224323695;57207620839;46061818500;57224321810;56483277100;57194156387;57189612709;57204644036;56323903000;55183784100; |
Helicobacter pylori in the Indonesian Malay’s descendants might be imported from other ethnicities |
2021 |
Gut Pathogens |
13 |
1 |
36 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107355307&doi=10.1186%2fs13099-021-00432-6&partnerID=40&md5=50dff7290d04b23d89863e54b90dceb8 |
Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine-Cipto Mangunkusumo Teaching Hospital, University of Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia; Department of Internal Medicine, Faculty of Medicine, University of Muhammadiyah Surabaya, Surabaya, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, Dr. Zainoel Abidin General Hospital, Universitas Syiah Kuala, Banda Aceh, Indonesia; Department of Internal Medicine, Dr. M Thomsen Nias Gunungsitoli General Hospital, Nias, Indonesia; Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, Sriwijaya University, Palembang, Indonesia; Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Andalas University, Padang, Indonesia; Department of Internal Medicine, Cimacan General Hospital, Cianjur, Indonesia; Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Sumatera Utara, Medan, Indonesia; Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr Soetomo Teaching Hospital, Universitas Airlangga, Jalan Mayjend Prof. Dr. Moestopo No. 6-8, Surabaya, 60286, Indonesia; Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama Machi, Yufu City, Oita, 879-5593, Japan; Department of Medicine, Gastroenterology and Hepatology Section, Baylor College of Medicine, Houston, TX, United States |
Syam, A.F., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine-Cipto Mangunkusumo Teaching Hospital, University of Indonesia, Jakarta, Indonesia; Waskito, L.A., Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia, Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia; Rezkitha, Y.A.A., Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia, Department of Internal Medicine, Faculty of Medicine, University of Muhammadiyah Surabaya, Surabaya, Indonesia; Simamora, R.M., Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Yusuf, F., Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, Dr. Zainoel Abidin General Hospital, Universitas Syiah Kuala, Banda Aceh, Indonesia; Danchi, K.E., Department of Internal Medicine, Dr. M Thomsen Nias Gunungsitoli General Hospital, Nias, Indonesia; Bakry, A.F., Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, Sriwijaya University, Palembang, Indonesia; Arnelis, Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Andalas University, Padang, Indonesia; Mulya, E., Department of Internal Medicine, Cimacan General Hospital, Cianjur, Indonesia; Siregar, G.A., Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Sumatera Utara, Medan, Indonesia; Sugihartono, T., Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr Soetomo Teaching Hospital, Universitas Airlangga, Jalan Mayjend Prof. Dr. Moestopo No. 6-8, Surabaya, 60286, Indonesia; Maulahela, H., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine-Cipto Mangunkusumo Teaching Hospital, University of Indonesia, Jakarta, Indonesia; Doohan, D., Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Miftahussurur, M., Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia, Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr Soetomo Teaching Hospital, Universitas Airlangga, Jalan Mayjend Prof. Dr. Moestopo No. 6-8, Surabaya, 60286, Indonesia; Yamaoka, Y., Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama Machi, Yufu City, Oita, 879-5593, Japan, Department of Medicine, Gastroenterology and Hepatology Section, Baylor College of Medicine, Houston, TX, United States |
Background: Even though the incidence of H. pylori infection among Malays in the Malay Peninsula is low, we observed a high H. pylori prevalence in Sumatra, which is the main residence of Indonesian Malays. H. pylori prevalence among Indonesian Malay descendants was investigated. Results: Using a combination of five tests, 232 recruited participants were tested for H- pylori and participants were considered positive if at least one test positive. The results showed that the overall H. pylori prevalence was 17.2%. Participants were then categorized into Malay (Aceh, Malay, and Minang), Java (Javanese and Sundanese), Nias, and Bataknese groups. The prevalence of H. pylori was very low among the Malay group (2.8%) and no H. pylori was observed among the Aceh. Similarly, no H. pylori was observed among the Java group. However, the prevalence of H. pylori was high among the Bataknese (52.2%) and moderate among the Nias (6.1%). Multilocus sequence typing showed that H. pylori in Indonesian Malays classified as hpEastAsia with a subpopulation of hspMaori, suggesting that the isolated H. pylori were not a specific Malays H. pylori. Conclusions: Even though the ethnic groups live together as a community, we observed an extremely low H. pylori infection rate among Indonesian Malay descendants with no specific Indonesian Malay H. pylori. The results suggest that H. pylori was not originally among these groups and H. pylori was imported from other ethnic groups. © 2021, The Author(s). |
Epidemiology; Helicobacter pylori; Malays; Population genetics; Prevalence; Sumatra |
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BioMed Central Ltd |
17574749 |
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Article |
Q2 |
1026 |
4226 |
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83 |
Triwidodo A., Rahyussalim A.J., Yulisa N.D., Pandelaki J., Huraiby L.S., Hadi I.A.N., Liosha F.Y., Dilogo I.H. |
57222626174;55212166100;57191033188;35759266900;57410470800;57345259600;57195941059;56161962800; |
Sacrum morphometry and spinopelvic parameters among the Indonesian population using computed tomography scans |
2021 |
Medicine (United States) |
100 |
47 |
e27955 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122758150&doi=10.1097%2fMD.0000000000027955&partnerID=40&md5=fcef27e030576bfa693c1f9a81c6abd9 |
Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Radiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Triwidodo, A., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rahyussalim, A.J., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Yulisa, N.D., Department of Radiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Pandelaki, J., Department of Radiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Huraiby, L.S., Department of Radiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hadi, I.A.N., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Liosha, F.Y., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Dilogo, I.H., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
This is a cross-sectional study. This study aims to describe the characteristics of sacrum vertebrae and spinopelvic parameters among the Indonesian population and compare them with studies from other populations. This study also intends to determine the sexual dimorphism of sacrum vertebrae and find the correlations between spinopelvic parameters. Morphometry of the sacrum is necessary for designing sacral prosthesis and instrumentations. Knowledge of spinopelvic parameters further supports the prosthesis installation procedure to restore the physiological spinal alignment of the patients. However, previous studies showed varied results among different populations. This is the first study to be conducted among the Indonesian population. Morphometric dimensions of sacrum vertebrae and the spinopelvic parameters (pelvic incidence, pelvic tilt, sacral slope, lumbar lordosis) were analyzed using thin-cut (1 mm) computed tomography images in 150 males and 150 females, aged 25 to 50 years without any spinal pathology. Generally, the size of the sacrum vertebrae was greater in males (P < .05). The sacral index, curvature index, and corporo-basal index were statistically different between genders (P < .001). Lumbar lordosis was the only spinopelvic parameter found significantly greater in females (P < .001). Significant positive correlations between all spinopelvic parameters, except for lumbar lordosis and pelvic tilt, were found in the present study (P < .001). The study serves as the first large series database of sacrum morphometric characteristics and spinopelvic parameters of the Indonesian population. There was significant gender-associated differences in various dimensions of sacrum vertebrae. The sacral index was found to be the most useful parameter for sex determination. There were strong significant positive correlations between various spinopelvic parameters. A comparison of populations revealed morphometric characteristic differences, which is proved to be critical in surgical implications. Copyright © 2021 the Author(s). |
Computed tomography scans; Indonesian population; Morphometry; Sacrum vertebrae; Spinopelvic parameters |
adult; cross-sectional study; diagnostic imaging; female; human; Indonesia; lumbar vertebra; male; middle aged; pelvis; sacrum; sexual characteristics; x-ray computed tomography; Adult; Cross-Sectional Studies; Female; Humans; Indonesia; Lumbar Vertebrae; Male; Middle Aged; Pelvis; Sacrum; Sex Characteristics; Tomography, X-Ray Computed |
Lippincott Williams and Wilkins |
00257974 |
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34964781 |
Article |
Q2 |
590 |
8573 |
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94 |
Subahar R., Susanto L., Aidilla R., Aulia A.P., Yulhasri Y., Winita R., Lubis N.S., Sari I.P. |
6508197883;6507704130;57365800900;57366528800;57225180520;57220782528;57222661567;57197543698; |
In vitro experiments of Pediculus humanus capitis (Phthiraptera: Pediculidae) resistance to permethrin and 6-paradol in East Jakarta: Detoxification enzyme activity and electron microscopic changes in lice |
2021 |
Veterinary World |
14 |
11 |
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3065 |
3075 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120814548&doi=10.14202%2fvetworld.2021.3065-3075&partnerID=40&md5=1d1646983a8b7f7da98a7d4f5896e795 |
Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Medical Doctor Program, Faculty of Medicine, University of Indonesia, Jl. Salemba 4, Jakarta, 10430, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Indonesia, Jln. Salemba Raya 4, Jakarta, 10430, Indonesia |
Subahar, R., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Susanto, L., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Aidilla, R., Medical Doctor Program, Faculty of Medicine, University of Indonesia, Jl. Salemba 4, Jakarta, 10430, Indonesia; Aulia, A.P., Medical Doctor Program, Faculty of Medicine, University of Indonesia, Jl. Salemba 4, Jakarta, 10430, Indonesia; Yulhasri, Y., Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Indonesia, Jln. Salemba Raya 4, Jakarta, 10430, Indonesia; Winita, R., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Lubis, N.S., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Sari, I.P., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia |
Background and Aim: Pediculus humanus capitis, the human head louse, remains a global health problem. This study evaluated the resistance of head lice to permethrin and 6-paradol mediated by in vitro detoxification enzyme activity experiments and to describe physical changes in the lice using scanning electron microscopy (SEM). Materials and Methods: The adult stages of P. h. capitis were collected from patients exposed to 1% permethrin and three different concentrations of 6-paradol (0.00005%, 0.0001%, and 0.00015%) using a filter paper diffusion bioassay. Healthy P. h. capitis adults served as the control. The in vitro bioassays were conducted after 10, 20, 30, and 60 min of exposure. The activities of acetylcholinesterase (AChE), glutathione S-transferase (GST), and oxidase were analyzed. Physical changes in the lice were analyzed using SEM. Results: Permethrin and 6-paradol exhibited low toxicity against the lice. At 60 min, 1% permethrin had killed 36.7% of the lice present, while 6-paradol had killed 66.7-86.7%. Permethrin induced significantly elevated AChE, GST, and oxidase activity; 6-paradol also caused significantly elevated AChE, GST, and oxidase activity. Permethrin did not cause any ultrastructural morphological changes on the lice, while 6-paradol severely damaged the head, thorax, respiratory spiracles, and abdomen of the dead lice. Conclusion: This in vitro experimental of P. h. capitis is the first study to report P. h. capitis in East Jakarta shows complete resistance to permethrin and 6-paradol, and to describe the associated increase in AChE, GST, and oxidase activity. It was observed that 6-paradol severely damaged the head, thorax, respiratory spiracles, and abdomen of the dead lice. © 2021 Veterinary World. All rights reserved. |
6-paradol; Detoxifying enzyme; Electron microscopy; Pediculus humanus capitis; Permethrin; Resistance |
6 paradol; acetylcholinesterase; chitin; glutathione transferase; oxidoreductase; permethrin; phenol derivative; unclassified drug; Article; bioassay; controlled study; detoxification; diffusion; enzyme activity; enzyme linked immunosorbent assay; hair loss; LT50; LT90; nonhuman; Pediculus humanus capitis; scanning electron microscopy; ultrastructure |
Veterinary World |
09728988 |
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Article |
Q2 |
550 |
9187 |
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