No records
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209 |
Lasmono A., Ismail R.I., Kaligis F., Minayati K., Wiguna T. |
57243772800;55996895500;36604651700;57218681686;24367785700; |
Empathy quotient and systemizing quotient in elementary school children with and without attention-deficit/hyperactivity disorder: A comparative study |
2021 |
International Journal of Environmental Research and Public Health |
18 |
17 |
9231 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114150588&doi=10.3390%2fijerph18179231&partnerID=40&md5=2177023e11ec7cb0573abfd7f195ae8f |
Department of Psychiatry, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, 10430, Indonesia; Child and Adolescent Psychiatry Division, Department of Psychiatry, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, 10430, Indonesia |
Lasmono, A., Department of Psychiatry, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, 10430, Indonesia; Ismail, R.I., Child and Adolescent Psychiatry Division, Department of Psychiatry, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, 10430, Indonesia; Kaligis, F., Child and Adolescent Psychiatry Division, Department of Psychiatry, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, 10430, Indonesia; Minayati, K., Child and Adolescent Psychiatry Division, Department of Psychiatry, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, 10430, Indonesia; Wiguna, T., Child and Adolescent Psychiatry Division, Department of Psychiatry, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, 10430, Indonesia |
This study compares the Empathy Quotient (EQ) and Systemizing Quotient (SQ) scores of elementary school children with and without ADHD. The study also examined their brain types and, because sex plays a big role in empathy and systemizing ability, compared the results of the boys and girls. This cross-sectional study involved 122 participants, including 61 parents of children with ADHD and 61 parents of children without ADHD. The EQ, SQ and brain types were obtained using the Empathy and Systemizing Quotient in children (EQ-/SQ-C), validated in the Indonesian language. Data was analyzed using the SPSS program version 20 for Windows, with a p-value < 0.05 for statistical significance. There was a significant difference in EQ between children with and without ADHD, the score being lower in children with ADHD. There was also a significant difference in SQ among girls with and without ADHD, but not in boys. The brain types in both groups were not significantly different. The results indicate that children with ADHD have a lower ability to empathize compared to children without ADHD. Systemizing abilities were significantly lower in girls with ADHD than in girls without. Therefore, an intervention program focusing on improving empathy and systemizing ability needs to be developed in the community. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
ADHD; Children; Empathy quotient; EQ; Indonesia; SQ; Systemizing quotient |
child health; comparative study; health care; public health; adult; Article; attention deficit disorder; behavior assessment; child; comparative study; controlled study; cross-sectional study; elementary student; empathy; empathy quotient; female; human; human relation; ICD-10; Indonesian; Kolmogorov Smirnov test; major clinical study; male; school child; self concept; sex difference; social psychology; systemizing; systemizing quotient; validation study; attention deficit disorder; brain; school; Indonesia; Attention Deficit Disorder with Hyperactivity; Brain; Child; Cross-Sectional Studies; Empathy; Female; Humans; Male; Schools |
MDPI |
16617827 |
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34501828 |
Article |
Q2 |
747 |
6560 |
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210 |
Nurhayati R.W., Cahyo R.D., Pratama G., Anggraini D., Mubarok W., Kobayashi M., Antarianto R.D. |
55748436600;57212460506;57195959221;57221606578;57208440063;20835016200;57190862806; |
Alginate-chitosan microencapsulated cells for improving cd34+ progenitor maintenance and expansion |
2021 |
Applied Sciences (Switzerland) |
11 |
17 |
7887 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114106674&doi=10.3390%2fapp11177887&partnerID=40&md5=8aa18a5d52c69e6eb72dcb38252f4489 |
Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Jl. Prof. Soemantri Brojonegoro, Kampus UI, Depok, 16424, Indonesia; Stem Cells & Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia; Department of Biotechnology, Faculty of Engineering, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan; Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jl. Diponegoro No. 71, Central Jakarta, 10430, Indonesia; Integrated Service Unit of Stem Cell Medical Technology (IPT TK Sel Punca), Dr. Cipto Mangunkusumo General Hospital (RSCM), Jl. Diponegoro No. 71, Salemba, Central Jakarta, 10430, Indonesia; Division of Materials Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, 630-0192, Japan; Division of Chemical Engineering, Department of Materials Engineering Science, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama-cho, Toyonaka, Osaka, 560-8531, Japan; Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, 630-0192, Japan; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia |
Nurhayati, R.W., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Jl. Prof. Soemantri Brojonegoro, Kampus UI, Depok, 16424, Indonesia, Stem Cells & Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia; Cahyo, R.D., Stem Cells & Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia, Department of Biotechnology, Faculty of Engineering, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan; Pratama, G., Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jl. Diponegoro No. 71, Central Jakarta, 10430, Indonesia, Integrated Service Unit of Stem Cell Medical Technology (IPT TK Sel Punca), Dr. Cipto Mangunkusumo General Hospital (RSCM), Jl. Diponegoro No. 71, Salemba, Central Jakarta, 10430, Indonesia; Anggraini, D., Stem Cells & Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia, Division of Materials Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, 630-0192, Japan; Mubarok, W., Stem Cells & Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia, Division of Chemical Engineering, Department of Materials Engineering Science, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama-cho, Toyonaka, Osaka, 560-8531, Japan; Kobayashi, M., Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, 630-0192, Japan; Antarianto, R.D., Stem Cells & Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia, Department of Histology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia |
Protocols for isolation, characterization, and transplantation of hematopoietic stem cells (HSCs) have been well established. However, difficulty in finding human leucocyte antigens (HLA)-matched donors and scarcity of HSCs are still the major obstacles of allogeneic transplanta-tion. In this study, we developed a double-layered microcapsule to deliver paracrine factors from non-matched or low-matched HSCs to other cells. The umbilical cord blood-derived hematopoietic progenitor cells, identified as CD34+ cells, were entrapped in alginate polymer and further protected by chitosan coating. The microcapsules showed no toxicity for surrounding CD34+ cells. When CD34+ cells-loaded microcapsules were co-cultured with bare CD34+ cells that have been collected from unrelated donors, the microcapsules affected surrounding cells and increased the percentage of CD34+ cell population. This study is the first to report the potency of alginate-chitosan microcap-sules containing non-HLA-matched cells for improving proliferation and progenitor maintenance of CD34+ cells. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Alginate; CD34; Chitosan; Hematopoietic; Megakaryocyte; Microencapsulation; Progenitor; Proliferation; Stem cells |
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MDPI |
20763417 |
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Article |
Q2 |
435 |
11324 |
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237 |
Suhaeri M., Kim Y.-M., Yunarti R.T., Song S.-C. |
56183087500;57294592700;56086215900;7403350156; |
Thermoresponsive and suspension forming cyclotriphosphazene conjugate for delivery vehicle of antitumor drug camptothecin |
2021 |
Journal of Drug Delivery Science and Technology |
64 |
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102049 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116958285&doi=10.1016%2fj.jddst.2020.102049&partnerID=40&md5=e52dca3896e5c2ec2892116e880dc19c |
Unit of Education, Research and Training, Universitas Indonesia Hospital, Universitas Indonesia, Depok, 16424, Indonesia; Medical Technology Research Cluster, Indonesia Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, 10430, Indonesia; Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, 10430, Indonesia; Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science & Technology, Seoul, 02792, South Korea; Inorganic Chemistry Research Laboratory, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Kampus UI Baru, Depok, Jawa Barat 16424, Indonesia; Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Seoul, 02792, South Korea |
Suhaeri, M., Unit of Education, Research and Training, Universitas Indonesia Hospital, Universitas Indonesia, Depok, 16424, Indonesia, Medical Technology Research Cluster, Indonesia Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, 10430, Indonesia, Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, 10430, Indonesia; Kim, Y.-M., Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science & Technology, Seoul, 02792, South Korea, Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Seoul, 02792, South Korea; Yunarti, R.T., Inorganic Chemistry Research Laboratory, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Kampus UI Baru, Depok, Jawa Barat 16424, Indonesia; Song, S.-C., Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science & Technology, Seoul, 02792, South Korea, Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Seoul, 02792, South Korea |
Camptothecin (CPT) has been used as antitumor drug against a wide range of cancer cells. However, its clinical application is greatly hindered by insolubility and instability issues under physiological condition. Therefore, an appropriate CPT administration technique directed for living system is greatly anticipated. In this study, a delivery method for CPT in the form of thermoresponsive system was prescribed. A conjugate of cyclotriphosphazene and CPT was synthesized by substituting hexachlorocyclotriphosphazene with sodium salt of methoxy-poly (ethylene glycol) (Mw = 350), 20-O-trifluoroglycinylCPT, and isoleucine ethyl ester, respectively. The resulting cyclotriphosphazene-CPT was characterized via multinuclear (1H and 31P) NMR as well as FT-IR. The current conjugate showed temperature induced phase transition (solution to suspension) with a lower critical solution temperature at 31 °C. Our result indicated that the stability issue related to the use of CPT in aqueous solution could be handled by acylation at 20-OH moiety. Additionally, antitumor activity of cyclotriphosphazene-CPT, to some extent, was found to be more profound than that of CPT alone as evaluated against human colorectal cancer cell HCT-116. Altogether, the current cyclotriphosphazene-CPT conjugate might offer a facile method in delivering CPT as a minimally invasive system for treating cancer. © 2020 Elsevier B.V. |
Antitumor; Camptothecin; Conjugate; Cyclotriphosphazene; Drug delivery; Thermoresponsive |
camptothecin; hexachlorocyclotriphosphazene; isoleucine; macrogol; polymer; sodium; unclassified drug; antineoplastic activity; Article; critical solution temperature; drug conjugation; drug delivery system; drug structure; drug synthesis; Fourier transform infrared spectroscopy; HCT 116 cell line; human; human cell; phase transition; phosphorus nuclear magnetic resonance; proton nuclear magnetic resonance; temperature |
Editions de Sante |
17732247 |
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Article |
Q2 |
663 |
7562 |
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242 |
Bintoro D.A., Nareswari I. |
57237633100;57194336586; |
The Role of Electroacupuncture in the Regulation of Appetite-Controlling Hormone and Inflammatory Response in Obesity |
2021 |
Medical Acupuncture |
33 |
4 |
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264 |
268 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113821541&doi=10.1089%2facu.2020.1500&partnerID=40&md5=b4a919cddf828d9f0978d90ea651ac42 |
Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central Public Hospital, Central Jakarta, Jakarta, Indonesia |
Bintoro, D.A., Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central Public Hospital, Central Jakarta, Jakarta, Indonesia; Nareswari, I., Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central Public Hospital, Central Jakarta, Jakarta, Indonesia |
Objective: Obesity, a condition with serious complications, needs special attention. It is a complex and multifactorial problem and regulation of calorie balance involving various humoral and central factors is the main key for managing obesity. In addition, there is an increase in various proinflammatory cytokines and an increase in oxidative stress. There is a need to discover a useful therapy for obesity management. The goal of this review was to examine the literature on electroacupuncture (EA) as a potential therapy. Methods: This review explores the literature on EA, which has proven to be effective for inducing weight loss in experimental human and animal studies. Both continuous and dense-disperse EA waves have their own roles in hormone regulation of obesity using ST 25, CV 9, CV 12, CV 4, SP 6, ST 36, and ST 44; this is discussed the associated mechanism related to this is through suppression of various orexigenic peptides, enhancement of anorexigenic peptides, suppression of inflammatory factors, and improvement in the balance of pro-oxidants and antioxidants. Conclusions: The absence of another definitive therapy for obesity and EA's minimal side-effects make it a potential therapy for managing obesity. © Copyright 2021, Mary Ann Liebert, Inc., publishers 2021. |
electroacupuncture; inflammation; obesity; oxidative stress |
ghrelin; acupuncture; appetite; body weight loss; electroacupuncture; food intake; human; inflammation; nonhuman; obesity; oxidative stress; pathophysiology; Review |
Mary Ann Liebert Inc. |
19336586 |
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Review |
Q2 |
281 |
15498 |
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243 |
Nareswari I., Lestari S.W., Notonegoro C. |
57194336586;55980501200;57224857889; |
Acupuncture Therapy for Severe Oligoasthenoteratozoospermia |
2021 |
Medical Acupuncture |
33 |
4 |
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302 |
305 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113775889&doi=10.1089%2facu.2020.1513&partnerID=40&md5=04fcbc629e9b71da58c0b69ee5116b7c |
Department of Medical Acupuncture, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Anna Hospital, Pekayon, Indonesia; Medical Acupuncture Specialist Program, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Nareswari, I., Department of Medical Acupuncture, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Anna Hospital, Pekayon, Indonesia, Medical Acupuncture Specialist Program, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Lestari, S.W., Anna Hospital, Pekayon, Indonesia, Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Notonegoro, C., Department of Medical Acupuncture, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Medical Acupuncture Specialist Program, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: Infertility affects ∼15%-20% of couples. Of the 16.7% infertility rate reported based on Word Health Organisation questionnaire data, 6.4% of cases are associated with male factors. Male infertility can result from abnormal semen parameters; oligoasthenoteratozoospermia (OAT) is the most common diagnosis. Acupuncture is an ancient method that has been used for centuries to treat and prevent various conditions. In modern medicine, it is gaining popularity as a complementary infertility therapy. Case: A 41-year-old male presented to the Medical Acupuncture Department of Dr. Cipto Mangunkusumo Hospital (in Jakarta, Indonesia) because he wanted to have a child. His semen was analyzed, and he was diagnosed with severe OAT. Manual acupuncture therapy was performed at CV 3, CV 4, CV 5, CV 6, CV 7, ST 29, SP 6, SP 3, ST 36, and KI 3, alternating with KI 7 5 days per week and at LR 8 once per week, for a total of 28 sessions. Results: Semen analysis after 2 series of manual acupuncture treatments revealed improvement, especially in sperm motility, from 25% to 33% and then to 67% after the first and second serial therapies, respectively, changing the diagnosis from severe OAT to severe oligoteratozoospermia. Conclusions: Manual acupuncture combined with medication improves male fertility, especially sperm motility. © Copyright 2021, Mary Ann Liebert, Inc., publishers 2021. |
Acupuncture; Male Infertility; Oligoasthenoteratozoospermia |
alpha tocopherol; ascorbic acid; beta carotene; clomifene citrate; glutathione; lycopene; mineral; selenium; ubidecarenone; zinc; acupuncture; acupuncture point; adult; Article; case report; clinical article; follow up; high fiber diet; human; Indonesia; male; male infertility; oligoasthenoteratozoospermia; semen analysis; spermatozoon motility; Tribulus terrestris |
Mary Ann Liebert Inc. |
19336586 |
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Article |
Q2 |
281 |
15498 |
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244 |
Djaali W. |
57212479564; |
How Do You Treat Non-Insulin Dependent Diabetes in Your Practice? |
2021 |
Medical Acupuncture |
33 |
4 |
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306 |
308 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113733355&doi=10.1089%2facu.2021.29182.cpl&partnerID=40&md5=d5215d516a5077a554bb640392817b63 |
Universitas Negeri Jakarta Jl. Rawamangun Muka East Jakarta, Jakarta, 13220, Indonesia; Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo Central Jakarta, Jakarta, Indonesia |
Djaali, W., Universitas Negeri Jakarta Jl. Rawamangun Muka East Jakarta, Jakarta, 13220, Indonesia, Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo Central Jakarta, Jakarta, Indonesia |
[No abstract available] |
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hemoglobin A1c; acupuncture; acupuncture point; adult; Article; case report; clinical article; evaluation study; evidence based practice; fatigue; glucose blood level; histology; human; male; middle aged; non insulin dependent diabetes mellitus; Research Diagnostic Criteria; signal transduction; somnolence; treatment planning |
Mary Ann Liebert Inc. |
19336586 |
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Article |
Q2 |
281 |
15498 |
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261 |
Pravian D., Soesanto A.M., Ambari A.M., Kuncoro B.R.M.A.S., Dwiputra B., Muliawan H.S., Sukmawan R. |
57223935749;56374199000;57189576921;57223920990;57195383994;57203644653;8651025300; |
The effect of external counterpulsation on intrinsic myocardial function evaluated by speckle tracking echocardiography in refractory angina patients: a randomized controlled trial |
2021 |
International Journal of Cardiovascular Imaging |
37 |
8 |
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2483 |
2490 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106531230&doi=10.1007%2fs10554-021-02289-x&partnerID=40&md5=205259fb7afb6a50c7b9b375ac603918 |
Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
Pravian, D., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Soesanto, A.M., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Ambari, A.M., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Kuncoro, B.R.M.A.S., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Dwiputra, B., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Muliawan, H.S., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Sukmawan, R., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
External Counterpulsation (ECP) is one of the therapeutic options in patients with refractory angina inadequately controlled by medical, interventional, or surgical therapy. The 2D Speckle Tracking Echocardiography (2D-STE) method is considered superior in assessing clinical improvement. We would like to evaluate any improvement of myocardial intrinsic function using 2D-STE in patients underwent standard ECP protocol (35 sessions). We conducted a double-blind randomized controlled trial. Patients with refractory angina who could not be revascularized conventionally were randomized into two groups: (1) the ECP group (300 mmHg) and (2) the Sham/control group (75 mmHg). ECP standard therapy was given for 35 sessions (1 h/day/session). The 2D-STE data, including longitudinal strain and post systolic index (PSI) were obtained before and after therapy. 43 subjects were analyzed, with 22 subjects in ECP group and 21 control subjects (Sham group). A homogenous baseline strain was found either globally (12.42 ± 4.55 vs 12.00 ± 4.92 [− %]; P = 0.774) or segmentally/regionally (12.63 (0.01–25.16) vs 12.43 (0.01–27.20) [− %]; P = 0.570). There was no statistically significant improvement between groups in the left ventricle longitudinal strain globally (P = 0.535) and segmentally/regionally (P = 0.434). PSI parameters showed improvement in the ECP group (P = 0.049), and segments with PSI ≥ 20% seemed to improve longitudinal strains in the ECP group after therapy (P = 0.042). In conclusion, 35 ECP therapy sessions did not improve either global or segmental/regional left ventricular mechanical function in patients with refractory angina. However, the mechanical function of myocardial segments with PSS tends to improve after ECP therapy. © 2021, The Author(s), under exclusive licence to Springer Nature B.V. |
2D speckle tracking echocardiography; External counterpulsation; Post systolic index; Refractory angina; Strain |
adult; aged; angina pectoris; Article; cardiovascular parameters; clinical article; clinical outcome; controlled study; counterpulsation; double blind procedure; female; follow up; heart function; heart left ventricle enddiastolic diameter; heart left ventricle endsystolic diameter; human; left ventricular global longitudinal strain; male; middle aged; post systolic index; post systolic shortening; randomized controlled trial; tricuspid annular plane systolic excursion; two dimensional speckle tracking echocardiography |
Springer Science and Business Media B.V. |
15695794 |
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34037889 |
Article |
Q2 |
726 |
6821 |
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265 |
Yuliwulandari R., Shin J.G., Kristin E., Suyatna F.D., Prahasto I.D., Prayuni K., Mahasirimongkol S., Cavallari L.H., Mitropoulou C., Patrinos G.P., Hao J., Williams M.S., Snyder S.R. |
23098874600;56031235700;6504458442;56039633100;57222660319;57190022456;14632559000;8396168500;37001846100;6603726539;57194283820;57203332674;7401687524; |
Cost-effectiveness analysis of genotyping for HLA-B*15:02 in Indonesian patients with epilepsy using a generic model |
2021 |
Pharmacogenomics Journal |
21 |
4 |
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476 |
483 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103643380&doi=10.1038%2fs41397-021-00225-9&partnerID=40&md5=927cb9a5fa739ff5a932d25eb4459bd0 |
Department of Pharmacology, Faculty of Medicine, YARSI University, Jakarta Pusat, Indonesia; Genetic Research Center, YARSI Research Institute, YARSI University, Jakarta Pusat, Indonesia; Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Busan, South Korea; Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan, South Korea; Department of Pharmacology and Therapy, Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia; Department of Pharmacology & Therapeutic, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia; Medical Genetics Section, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand; Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL, United States; The Golden Helix Foundation, London, United Kingdom; Department of Pharmacy, University of Patras, Patras, Greece; Department of Pathology, United Arab Emirates University College of Medicine and Health Sciences, Al-Ain, United Arab Emirates; Department of Population Health Sciences, Geisinger, Danville, PA, United States; Genomic Medicine Institute, Geisinger, Danville, PA, United States; Health Policy & Behavioral Sciences, Georgia State University, Atlanta, GA, United States |
Yuliwulandari, R., Department of Pharmacology, Faculty of Medicine, YARSI University, Jakarta Pusat, Indonesia, Genetic Research Center, YARSI Research Institute, YARSI University, Jakarta Pusat, Indonesia; Shin, J.G., Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Busan, South Korea, Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan, South Korea; Kristin, E., Department of Pharmacology and Therapy, Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia; Suyatna, F.D., Department of Pharmacology & Therapeutic, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia; Prahasto, I.D., Department of Pharmacology and Therapy, Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia; Prayuni, K., Genetic Research Center, YARSI Research Institute, YARSI University, Jakarta Pusat, Indonesia; Mahasirimongkol, S., Medical Genetics Section, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand; Cavallari, L.H., Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL, United States; Mitropoulou, C., The Golden Helix Foundation, London, United Kingdom; Patrinos, G.P., Department of Pharmacy, University of Patras, Patras, Greece, Department of Pathology, United Arab Emirates University College of Medicine and Health Sciences, Al-Ain, United Arab Emirates; Hao, J., Department of Population Health Sciences, Geisinger, Danville, PA, United States; Williams, M.S., Genomic Medicine Institute, Geisinger, Danville, PA, United States; Snyder, S.R., Health Policy & Behavioral Sciences, Georgia State University, Atlanta, GA, United States |
Carbamazepine (CBZ)-induced Stevens–Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are strongly associated with the HLA-B*15:02 allele. Screening HLA-B*15:02 before CBZ administration might prevent CBZ-induced SJS/TEN by enabling clinicians to prescribe alternative therapy for positive patients. Similar to other Southeastern Asian countries, HLA-B*15:02 is highly prevalent in Indonesia. Therefore, we assessed the economic value of HLA-B*15:02 screening before CBZ prescription to patients with epilepsy in Indonesia. A generic cost-effectiveness model and decision support tool, developed to enable users to perform an initial cost-effectiveness analysis from a healthcare provider/payer perspective, were used to assess the value of HLA-B*15:02 genotyping. The incremental cost-effectiveness ratio of adopting universal HLA-B*15:02 screening was 656,444,671 Indonesian Rupiah (IDR)/quality-adjusted life year (QALY) gained for patients compared with 2,634,975,574 IDR/QALY gained for providing valproic acid (alternative drug) without screening. Thus, neither HLA-B*15:02 screening nor substitution with VPA meets the Indonesian threshold for cost effectiveness. However, the improved outcomes with this test in other Asian countries may inform the desirability of implementation in Indonesia even with suboptimal cost-effectiveness. © 2021, The Author(s), under exclusive licence to Springer Nature Limited. |
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anticonvulsive agent; carbamazepine; HLA B antigen; valproic acid; anticonvulsive agent; carbamazepine; HLA B15 antigen; aged; Article; cost effectiveness analysis; epilepsy; epileptic patient; female; genotyping; human; Indonesian; Javanese (people); major clinical study; male; predictive value; prevalence; quality adjusted life year; sensitivity analysis; sensitivity and specificity; Stevens Johnson syndrome; Sundanese (people); toxic epidermal necrolysis; adult; allele; Asian; cost benefit analysis; epilepsy; genetic predisposition; genetic screening; genetics; genotype; Indonesia; procedures; risk factor; Adult; Alleles; Anticonvulsants; Asians; Carbamazepine; Cost-Benefit Analysis; Epilepsy; Female; Genetic Predisposition to Disease; Genetic Testing; Genotype; HLA-B15 Antigen; Humans; |
Springer Nature |
1470269X |
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33824430 |
Article |
Q2 |
804 |
6015 |
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283 |
Meilia P.D.I., Zeegers M.P., Herkutanto, Freeman M.D. |
57204065074;7003691618;57204069374;34769701500; |
Medicolegal causation investigation of bacterial endocarditis associated with an oral surgery practice using the INFERENCE approach |
2021 |
International Journal of Environmental Research and Public Health |
18 |
14 |
7530 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110118162&doi=10.3390%2fijerph18147530&partnerID=40&md5=c18a2f743bdf484bc116e962d9bb593b |
Care and Public Health Research Institute (CAPHRI), Maastricht University Medical Center+, Universiteitssingel 40, Maastricht, 6229 ER, Netherlands; Department of Forensic Medicine and Medicolegal Studies, Faculty of Medicine, University of Indonesia, Jl. Salemba Raya No. 4, Salemba, Jakarta Pusat, 10430, Indonesia |
Meilia, P.D.I., Care and Public Health Research Institute (CAPHRI), Maastricht University Medical Center+, Universiteitssingel 40, Maastricht, 6229 ER, Netherlands; Zeegers, M.P., Care and Public Health Research Institute (CAPHRI), Maastricht University Medical Center+, Universiteitssingel 40, Maastricht, 6229 ER, Netherlands; Herkutanto, Department of Forensic Medicine and Medicolegal Studies, Faculty of Medicine, University of Indonesia, Jl. Salemba Raya No. 4, Salemba, Jakarta Pusat, 10430, Indonesia; Freeman, M.D., Care and Public Health Research Institute (CAPHRI), Maastricht University Medical Center+, Universiteitssingel 40, Maastricht, 6229 ER, Netherlands |
Investigating causation is a primary goal in forensic/legal medicine, aiming to establish the connection between an unlawful/negligent act and an adverse outcome. In malpractice litigation involving a healthcare-associated infection due to a failure of infection prevention and control prac-tices, the medicolegal causal analysis needs to quantify the individual causal probabilities to meet the evidentiary requirements of the court. In this paper, we present the investigation of the most probable cause of bacterial endocarditis in a patient who underwent an invasive procedure at a dental/oral surgical practice where an outbreak of bacterial endocarditis had already been identified by the state Department of Health. We assessed the probability that the patient’s endocarditis was part of the outbreak versus that it was an unrelated sporadic infection using the INFERENCE (Integration of Forensic Epidemiology and the Rigorous Evaluation of Causation Elements) approach to medicolegal causation analysis. This paper describes the step-by-step application of the INFERENCE approach to demonstrate its utility in quantifying the probability of causation. The use of INFERENCE provides the court with an evidence-based, transparent, and reliable guide to determine liability, causation, and damages. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Bacterial endocarditis; Infection prevention and control practices; INFERENCE approach; Malpractice litigation; Medicolegal causal analysis; Quantification of causation |
bacterium; disease control; forensic science; health care; infectious disease; medicine; oral health; quantitative analysis; adult; aged; aortic regurgitation; Article; bacteremia; bacterial endocarditis; cardiomegaly; dizziness; dyspnea; electrocardiography; emergency ward; Enterococcus faecalis; female; fever; follow up; hospitalization; human; infection prevention; legal epidemiology; lumpectomy; male; malpractice; night sweat; nuclear magnetic resonance imaging; oral surgery; public health; transesophageal echocardiography; bacterial endocarditis; causality; forensic medicine; malpractice; Bacteria (microorganisms); Causality; Endocarditis, Bacterial; Forensic Medicine; Humans; Malpractice; Oral Surgical Procedures |
MDPI |
16617827 |
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34299979 |
Article |
Q2 |
747 |
6560 |
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299 |
SITOHANG I.B.S., ANWAR A.I., JUSUF N.K., ARIMUKO A., NORAWATI L., VERONICA S. |
56734569200;57205655192;57188840371;57222706279;57217009388;57217003979; |
Evaluating oral glutathione plus ascorbic acid, alpha-lipoic acid, and zinc aspartate as a skin-lightening agent: An indonesian multicenter, randomized, controlled trial |
2021 |
Journal of Clinical and Aesthetic Dermatology |
14 |
7 |
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E53 |
E58 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113537297&partnerID=40&md5=f7d6f0bdd3408b798182f7ccc399f039 |
Division of Cosmetic Dermatology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine Universitas Hasanuddin Dr. Wahidin Sudirohusodo Hospital, Makassar, Indonesia; Division of Cosmetic Dermatology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara-Universitas Sumatera Utara Hospital, Medan, Indonesia; Department of Dermatology and Venereology, Presidential-Army Central Hospital Gatot Soebroto, Jakarta, Indonesia |
SITOHANG, I.B.S., Division of Cosmetic Dermatology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; ANWAR, A.I., Department of Dermatology and Venereology, Faculty of Medicine Universitas Hasanuddin Dr. Wahidin Sudirohusodo Hospital, Makassar, Indonesia; JUSUF, N.K., Division of Cosmetic Dermatology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara-Universitas Sumatera Utara Hospital, Medan, Indonesia; ARIMUKO, A., Department of Dermatology and Venereology, Presidential-Army Central Hospital Gatot Soebroto, Jakarta, Indonesia; NORAWATI, L., Department of Dermatology and Venereology, Presidential-Army Central Hospital Gatot Soebroto, Jakarta, Indonesia; VERONICA, S., Department of Dermatology and Venereology, Presidential-Army Central Hospital Gatot Soebroto, Jakarta, Indonesia |
CLINICALTRIALS.GOV IDENTIFIER: NCT04105504. BACKGROUND: For Asians, especially women with darker skin tones (Fitzpatrick Skin Types IV and V), clear, bright skin is considered highly desirable, and various topical, oral, or injection-based cosmetic skin-lightening agents with different mechanisms of action are widely available across Asia. OBJECTIVE: We sought to investigate the effcacy and safety of an oral glutathione supplement comprising L-glutathione (fermentation), ascorbic acid, alpha-lipoic acid, and zinc (as zinc aspartate) as a skin-lightening agent. METHODS: This randomized, double-blind, controlled clinical trial was carried out at three teaching hospital-based dermatovenereology clinics in Indonesia. Participants were randomized to receive either the glutathione supplement or placebo capsules and were evaluated every four weeks over a 12-week study period. Total reduction in spot ultraviolet, spot polarization, and skin tone were measured and recorded using a Janus Facial Analysis System® (PIE Co., Ltd, Suwon-si, Gyeonggido, Korea). RESULTS: Eighty-three participants, aged between 33 and 50 years, completed the study. Reductions in spot ultraviolet in certain subgroups, spot polarization, and skin tone were greater in the glutathione supplement group than in the placebo group, but the difference was not statistically significant. Both the glutathione supplement and placebo groups experienced only mild side effects in the first four weeks. CONCLUSION: The oral glutathione supplement was slightly beneficial for skin lightening in particular subgroups, but the results were not statistically significant. Mild and temporary side effects were reported. Further research is required to more fully evaluate the effcacy of this glutathione supplement as a skin-lightening agent. © 2021 Matrix Medical Communications. All rights reserved. |
Glutathione plus; Skin tone; Skin-lightening agent; Spot polarization; Spot ultraviolet |
ascorbic acid; depigmenting agent; gelatin; glucose; glutathione; keratin; lynae mazthione; placebo; porphyrin; sunscreen; thioctic acid; zinc aspartate; acne; adult; Article; cheek; combination drug therapy; comedo; controlled clinical trial; controlled study; double blind procedure; drug capsule; drug efficacy; drug safety; epigastric pain; eye; female; follow up; forehead; human; Indonesia; major clinical study; melanogenesis; multicenter study; nausea; nose; outcome assessment; pigmentation; pruritus; randomized controlled trial; sebum; side effect; skin bump; skin disease; sun exposure; supplementation; teaching hospital; treatment duration; ultraviolet radiation; wrinkle |
Matrix Medical Communications |
19412789 |
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Article |
Q2 |
600 |
8425 |
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