No records
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357 |
Yuniar I. |
57222295046; |
Restrictive versus liberal fluid bolus therapy in septic shock children: An evidence-based case report |
2021 |
Critical Care and Shock |
24 |
3 |
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143 |
152 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108644226&partnerID=40&md5=42389d8b506d8b4bbacd5ec1431f9c34 |
Division of Pediatric Emergency and Hospitalization, Departement of Child Health, dr. Cipto, Mangunkusumo General Hospital, Faculty of Medicine, University of Indonesia, Indonesia |
Yuniar, I., Division of Pediatric Emergency and Hospitalization, Departement of Child Health, dr. Cipto, Mangunkusumo General Hospital, Faculty of Medicine, University of Indonesia, Indonesia |
Fluid bolus therapy (FBT) is one of prime management in early goal-directed therapy (EGDT) to achieve adequate cardiac output. The Fluid Expansion as Supportive Therapy (FEAST) tri-al, a randomized-clinical trial that was used as an evidence to support fluid resuscitation rec-ommendation in Surviving Sepsis Campaign (SSC) 2020, must be discontinued because of . increasing mortality in the group that received higher volume of FBT. We present a case of a 9-year-old girl, 15 kg, came to emergency ward with refractory septic shock and became fluid overload after the second FBT. This proceeding aimed to deliver evidence-based case practice if the comparison between liberal versus restrictive FBT in children with septic shock. © 2021, The Indonesian Foundation of Critical Care Medicine. All rights reserved. |
Fluid; Liberal; Pediatric; Restrictive; Resuscitation; Shock |
cefotaxime; dobutamine; furosemide; oxygen; paracetamol; procalcitonin; Ringer lactate solution; vasoactive agent; Article; case report; child; clinical article; comparative effectiveness; drug dose titration; dyspnea; early goal-directed therapy; emergency ward; evidence based practice; female; fluid bolus therapy; fluid resuscitation; forward heart failure; heart afterload; heart muscle contractility; heart preload; hemodynamic monitoring; human; hypervolemia; hypotension; hypovolemic shock; mortality; pediatric intensive care unit; pericardial effusion; school child; septic shock; tachycardia |
The Indonesian Foundation of Critical Care Medicine |
14107767 |
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Article |
Q4 |
134 |
24890 |
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679 |
Akbar R., George Y., Madjid A.S., Sedono R., Tantri A. |
57317624300;26027840300;57163353500;56660590500;57188933853; |
Early administration of norepinephrine prevents the occurrence of fluid overload in the resuscitation of septic shock patients |
2021 |
Critical Care and Shock |
September 2021 |
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257 |
268 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118270800&partnerID=40&md5=d27a72a8961cf30e6da6e5952895aa23 |
Trainee of Intensive Care Fellowship Program, University of Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Medical Faculty, Haluoleo University-Konawe General Hos-pital, Konawe, Indonesia; Emergency and Intensive Care Unit-Pondok Indah Hospital Jakarta and Departement of Anesthesiology and Intensive Therapy-Faculty of Medicine Universitas, Indonesia; Department of Anesthesiology and Intensive Care, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia |
Akbar, R., Trainee of Intensive Care Fellowship Program, University of Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Medical Faculty, Haluoleo University-Konawe General Hos-pital, Konawe, Indonesia; George, Y., Emergency and Intensive Care Unit-Pondok Indah Hospital Jakarta and Departement of Anesthesiology and Intensive Therapy-Faculty of Medicine Universitas, Indonesia; Madjid, A.S., Department of Anesthesiology and Intensive Care, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Sedono, R., Department of Anesthesiology and Intensive Care, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Tantri, A., Department of Anesthesiology and Intensive Care, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia |
Background: Critically ill patients with sepsis usually receive a very large volume of fluids cau-sing a very significant positive fluid balance in an effort to meet the needs of cardiac output, syste-mic blood pressure, and perfusion to the kidneys. This condition also tends to be associated with poor survival rates. The aim of this study was to determine whether early maintenance of norepi-nephrine can reduce fluid administration and prevent overload in the resuscitation of patients with septic shock. Methods: This study was a randomized, non-blind clinical trial, of which the subjects were adult patients with septic shock admitted to the intensive and emergency care unit from January to November 2020. There were two treatment groups of this study, the early norepinephrine group (NEP group) and the 30 ml/kgBW fluid resuscitation one (Fluid group). The test was con-ducted on the urinary albumin-to-creatinine ra-tio, increase of serum creatinine value, ratio of arterial oxygen partial pressure to fractional in-spired oxygen (PaO2/FiO2 ratio), and intra-ab-dominal pressure at the time of septic shock di-agnosis was established, 3 hours, and 24 hours . after the treatment was given. The data was pro-cessed using the SPSS device. Results: Based on the analysis, it was found that there were significant differences in all study va-riables of the Fluid group compared to the NEP group. The amount of fluid administration in the NEP group averaged 2198.63 ml, less than that in the Fluid group with an average of 3999.30 ml (chi square test p=0.000). By comparing the measurement results to the initial measurement values in the two groups, the fluid overload was high-risk in the Fluid group. There was a significant relationship between the urinary albumin-to-creatinine ratio (OR=48.273; 95% CI=16.708-139.472), the increase in serum crea-tinine value (OR=73.381; 95% CI=19.955-269.849), the low PaO2/FiO2 ratio (OR=12.225; 95% CI=5.290-28.252), and the increase in intra-abdominal pressure (OR=32.667; 95% CI=10.490-101.724) with the provision of 30 ml/kgBW fluid resuscitation, which indicated the risk of fluid overload. Conclusion: Early norepinephrine administration can reduce fluid administration and prevent overload in the resuscitation of patients with septic shock. © 2021, The Indonesian Foundation of Critical Care Medicine. All rights reserved. |
Early norepinephrine; Fluid overload; Septic shock |
noradrenalin; abdominal pressure; adult; aged; albumin to creatinine ratio; albuminuria; Article; blood volume; capillary leak syndrome; controlled study; creatinine blood level; emergency care; female; fraction of inspired oxygen; Horowitz index; human; hypervolemia; intensive care; major clinical study; male; randomized controlled trial; resuscitation; risk; septic shock; Sequential Organ Failure Assessment Score; systolic blood pressure |
The Indonesian Foundation of Critical Care Medicine |
14107767 |
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Article |
Q4 |
134 |
24890 |
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734 |
Pudjiadi A.H. |
18435202300; |
Sepsis-induced T-cell suppression in pediatric sepsis |
2021 |
Critical Care and Shock |
2021 |
July |
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172 |
180 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112603065&partnerID=40&md5=f1958f220fe6de69e13b086f449c61df |
Department of Child Health, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Pudjiadi, A.H., Department of Child Health, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Sepsis contributes to significant mortality and morbidity in children. Despite rigorous resusci-tation effort, adequate antibiotics and advanced medical support, a significant proportion still face mortality due to multiple organ failure. Re-. cent hypothesis suggests host’s immune response pathology in the form of compensatory anti-in-flammatory response syndrome (CARS). This review aims to elucidate the pathophysiology of immune paralysis, both affecting innate and acquired immunity. © 2021, The Indonesian Foundation of Critical Care Medicine. All rights reserved. |
Compensatory anti-inflammatory response syndrome; HLA-DR; Immunoparalysis; Sepsis; TNF-α |
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The Indonesian Foundation of Critical Care Medicine |
14107767 |
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Review |
Q4 |
134 |
24890 |
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No records
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150 |
Basrowi R.W., Rahayu E.M., Khoe L.C., Wasito E., Sundjaya T. |
57024210400;57275241200;56586245200;6506940239;57188810826; |
The road to healthy ageing: What has indonesia achieved so far? |
2021 |
Nutrients |
13 |
10 |
3441 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115825022&doi=10.3390%2fnu13103441&partnerID=40&md5=71597249210e18c8c5775dcf67e18dbe |
Occupational Medicine Division, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Medical and Science Affairs Division, Danone Specialized Nutrition Indonesia, Jakarta, 12950, Indonesia; Department of Anthropology, Faculty of Social and Political Science Universitas Indonesia, Depok, 16424, Indonesia; Laboratorium Political Psychology, Faculty of Psychology Universitas Indonesia, Depok, 16424, Indonesia |
Basrowi, R.W., Occupational Medicine Division, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Medical and Science Affairs Division, Danone Specialized Nutrition Indonesia, Jakarta, 12950, Indonesia; Rahayu, E.M., Department of Anthropology, Faculty of Social and Political Science Universitas Indonesia, Depok, 16424, Indonesia, Laboratorium Political Psychology, Faculty of Psychology Universitas Indonesia, Depok, 16424, Indonesia; Khoe, L.C., Occupational Medicine Division, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Wasito, E., Medical and Science Affairs Division, Danone Specialized Nutrition Indonesia, Jakarta, 12950, Indonesia; Sundjaya, T., Medical and Science Affairs Division, Danone Specialized Nutrition Indonesia, Jakarta, 12950, Indonesia |
The World Health Organization (WHO) has projected that the world should prepare for an aging society. As the fourth most populous country in the world, the elderly population in Indonesia is also continuously growing. In 2010, the proportion of the elderly group was merely 5%, and it is expected to increase to 11% in 2035. Understanding the current situation of the adult population in Indonesia would be crucial to prepare for the future aging population. This article analyzed the current socio-demographic status, nutrition status, nutrient intake, and health profile of the current Indonesian adult population through a literature review. The key issues to prepare for healthy aging in Indonesia are summarized. Acknowledging the profile of the adult and senior adult population in Indonesia will provide beneficial information for all stakeholders in preparing Indonesia for a better healthy aging population with improved quality of life. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Aging population; Demographic; Health profile; Healthy ageing; Nutritional status |
adult; aged; demography; female; healthy aging; human; human experiment; Indonesia; Indonesian; male; nutrient intake; nutritional status; quality of life; review; World Health Organization; epidemiology; health status; health survey; Indonesia; nutritional status; socioeconomics; Health Status; Healthy Aging; Humans; Indonesia; Nutritional Status; Public Health Surveillance; Quality of Life; Socioeconomic Factors |
MDPI |
20726643 |
|
34684441 |
Review |
Q1 |
1418 |
2497 |
|
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211 |
Angelin T.C., Bardosono S., Shinta D., Fahmida U. |
57235777300;21933841000;57237520500;14420783500; |
Growth, dietary intake, and vitamin D receptor (VDR) promoter genotype in Indonesian school-age children |
2021 |
Nutrients |
13 |
9 |
2904 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113740878&doi=10.3390%2fnu13092904&partnerID=40&md5=c7a37360e57bb2d193a5b68571b677d7 |
Southeast Asian Ministers of Education Organization Regional Center for Food and Nutrition (SEAMEO RECFON)-Pusat Kajian Gizi Regional, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, 10430, Indonesia |
Angelin, T.C., Southeast Asian Ministers of Education Organization Regional Center for Food and Nutrition (SEAMEO RECFON)-Pusat Kajian Gizi Regional, Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Nutrition, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, 10430, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, 10430, Indonesia; Shinta, D., Southeast Asian Ministers of Education Organization Regional Center for Food and Nutrition (SEAMEO RECFON)-Pusat Kajian Gizi Regional, Universitas Indonesia, Jakarta, 10430, Indonesia; Fahmida, U., Southeast Asian Ministers of Education Organization Regional Center for Food and Nutrition (SEAMEO RECFON)-Pusat Kajian Gizi Regional, Universitas Indonesia, Jakarta, 10430, Indonesia |
Nutrition has been known as a predominant factor associated with stunting. However, some studies have discovered a genetic contribution in calcium absorption that will affect growth, known as the VDR gene. The aim of this study was to assess the association between VDR gene polymorphism and dietary intake towards height-for-age z-score (HAZ) of elementary school children in Malang District, East Java. This study analyzed the baseline of a randomized trial in East Java, Indonesia. School children aged 8–10 years old (n = 142) were included in this study. Energy, protein, calcium, and vitamin D intakes were obtained using 4-day 24-h dietary recalls. Two SNPs located in the promoter region of VDR gene were selected (rs11568820 and rs4516035) and analyzed using Real-Time PCR. The result showed a significant correlation between energy and protein intake with HAZ of the children (p = 0.030 and p = 0.016, respectively). The association between VDR gene and HAZ was not found (p > 0.05). Adjusted by other factors, protein intake was significantly correlated with HAZ (β = 0.034, 95% CI 0.015–0.052, p < 0.001, adj. R2 = 0.089). The children in our study had a favorable VDR gene genotype, however the effect of VDR gene promoter activity might not be revealed due to very low vitamin D and calcium intake to stimulate intestinal calcium absorption which in turn affects HAZ. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Calcium; Children; Dietary intake; Height-for-age z-score (HAZ); Indonesia; Stunting; VDR gene; Vitamin D |
calcium; DNA; protein; vitamin D; vitamin D receptor; calcitriol receptor; vitamin D; Article; body height; calcium absorption; calcium intake; caloric intake; child; child growth; controlled study; correlational study; cross-sectional study; diarrhea; dietary intake; elementary student; female; food frequency questionnaire; gene frequency; genetic variability; genotype; helminthiasis; heterozygote; human; Indonesia; macronutrient intake; male; micronutrient intake; pathogenesis; prevalence; primary school; promoter region; protein intake; randomized controlled trial; real time polymerase chain reaction; respiratory tract infection; school child; semi quantitative food frequency questionnaire; single nucleotide polymorphism; stunting; sun exposure; sunlight; vitamin intake; administration |
MDPI |
20726643 |
|
34578782 |
Article |
Q1 |
1418 |
2497 |
|
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311 |
Sunardi D., Bardosono S., Basrowi R.W., Wasito E., Vandenplas Y. |
57192075078;21933841000;57024210400;6506940239;57223670656; |
Dietary determinants of anemia in children aged 6–36 months: A cross-sectional study in Indonesia |
2021 |
Nutrients |
13 |
7 |
2397 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109524537&doi=10.3390%2fnu13072397&partnerID=40&md5=2e8ac565ce8b6f3dd3f70a2de509a9ad |
Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, 10430, Indonesia; Medical Nutrition for Danone Specialized Nutrition, Yogyakarta, 55165, Indonesia; Vrije Universiteit Brussel (VUB), UZ Brussels, KidZ Health Castle, Brussels, 1090, Belgium |
Sunardi, D., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, 10430, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, 10430, Indonesia; Basrowi, R.W., Medical Nutrition for Danone Specialized Nutrition, Yogyakarta, 55165, Indonesia; Wasito, E., Medical Nutrition for Danone Specialized Nutrition, Yogyakarta, 55165, Indonesia; Vandenplas, Y., Vrije Universiteit Brussel (VUB), UZ Brussels, KidZ Health Castle, Brussels, 1090, Belgium |
Anemia has been acknowledged as worldwide problem, including in Indonesia. This cross-sectional study aims to explore dietary determinants as risk factors for anemia in children aged 6–36 months living in a poor urban area of Jakarta. The study was done in Kampung Melayu sub-district in Jakarta, Indonesia. Data was collected within two weeks in September–October 2020. A structured questionnaire for a 24-h recall and a semi-quantitative Food Frequency Questionnaire (FFQ) were used to collect the dietary intake data, and venous blood was withdrawn to determine the hemoglobin levels. Bivariate chi-square and multiple logistic regression tests were executed to explore the dietary determinant factors for anemia. We recruited 180 subjects. The average hemoglobin concentration was 11.4 ± 1.7 mg/dL; the anemia prevalence was 29.4%. The following variables were significantly associated with higher risk of anemia: no cow’s milk formula consumption, inadequate intake of fats, protein, calcium, vitamin D, iron, zinc, vitamin A, vitamin C, vitamin B6, and vitamin B12. Only cow’s milk formula consumption and zinc intake were revealed as the determinant factors of anemia. In conclusion, the prevalence of anemia was 29.4% among children aged 6–36 months old. Anemia was significantly associated with two dietary determinants as risk factors that are cow’s milk formula consumption and zinc intake. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Anemia; Cow’s milk; Cow’s milk formula; Indonesia; Toddler; Zinc |
biological marker; hemoglobin; zinc; adverse event; age; anemia; artificial milk; blood; bottle feeding; cross-sectional study; diet; female; human; Indonesia; infant; infant nutrition; male; metabolism; nutritional status; pathophysiology; preschool child; prevalence; risk assessment; risk factor; urban health; Age Factors; Anemia; Biomarkers; Bottle Feeding; Child, Preschool; Cross-Sectional Studies; Diet; Diet Surveys; Female; Hemoglobins; Humans; Indonesia; Infant; Infant Formula; Infant Nutritional Physiological Phenomena; Male; Nutritional Status; Prevalence; Risk Assessment; Risk Factors; Urban Health; Zinc |
MDPI AG |
20726643 |
|
34371908 |
Article |
Q1 |
1418 |
2497 |
|
|
901 |
Kadosh K.C., Muhardi L., Parikh P., Basso M., Mohamed H.J.J., Prawitasari T., Samuel F., Ma G., Geurts J.M.W. |
12243251700;57216729101;35269493300;57221482131;41861368100;57190686255;14421774000;57199673360;57197926057; |
Nutritional support of neurodevelopment and cognitive function in infants and young children—an update and novel insights |
2021 |
Nutrients |
13 |
1 |
199 |
1 |
26 |
|
4 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099415887&doi=10.3390%2fnu13010199&partnerID=40&md5=9754b1ffd94e454fc9ae27ba058537af |
School of Psychology, University of Surrey, Guildford, GU2 7XH, United Kingdom; FrieslandCampina AMEA, Singapore, 039190, Singapore; Department of General Psychology, University of Padova, Padova, 35131, Italy; Nutrition and Dietetics Programme, School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150, Malaysia; Nutrition and Metabolic Diseases Working Group, Indonesian Pediatric Society, Jakarta, 10310, Indonesia; Department of Pediatrics, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusomo National Referral Hospital Jakarta, Jakarta, 10430, Indonesia; Department of Human Nutrition, University of Ibadan, Ibadan, 200284, Nigeria; Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, 10019, China; Laboratory of Toxicological Research and Risk assessment for Food Safety, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, 100191, China; FrieslandCampina, Amersfoort, 3818 LE, Netherlands |
Kadosh, K.C., School of Psychology, University of Surrey, Guildford, GU2 7XH, United Kingdom; Muhardi, L., FrieslandCampina AMEA, Singapore, 039190, Singapore; Parikh, P., FrieslandCampina AMEA, Singapore, 039190, Singapore; Basso, M., School of Psychology, University of Surrey, Guildford, GU2 7XH, United Kingdom, Department of General Psychology, University of Padova, Padova, 35131, Italy; Mohamed, H.J.J., Nutrition and Dietetics Programme, School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150, Malaysia; Prawitasari, T., Nutrition and Metabolic Diseases Working Group, Indonesian Pediatric Society, Jakarta, 10310, Indonesia, Department of Pediatrics, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusomo National Referral Hospital Jakarta, Jakarta, 10430, Indonesia; Samuel, F., Department of Human Nutrition, University of Ibadan, Ibadan, 200284, Nigeria; Ma, G., Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, 10019, China, Laboratory of Toxicological Research and Risk assessment for Food Safety, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, 100191, China; Geurts, J.M.W., FrieslandCampina, Amersfoort, 3818 LE, Netherlands |
Proper nutrition is crucial for normal brain and neurocognitive development. Failure to optimize neurodevelopment early in life can have profound long-term implications for both mental health and quality of life. Although the first 1000 days of life represent the most critical period of neurodevelopment, the central and peripheral nervous systems continue to develop and change throughout life. All this time, development and functioning depend on many factors, including adequate nutrition. In this review, we outline the role of nutrients in cognitive, emotional, and neural development in infants and young children with special attention to the emerging roles of polar lipids and high quality (available) protein. Furthermore, we discuss the dynamic nature of the gut-brain axis and the importance of microbial diversity in relation to a variety of outcomes, including brain maturation/function and behavior are discussed. Finally, the promising therapeutic potential of psychobiotics to modify gut microbial ecology in order to improve mental well-being is presented. Here, we show that the individual contribution of nutrients, their interaction with other micro-and macronutrients and the way in which they are organized in the food matrix are of crucial importance for normal neurocognitive development. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Brain; Childhood; Gut-brain axis; Kynurenine; Minerals; Neurodevelopment; Polar lipids; Polyunsaturated fatty acids; Prebiotics; Probiotics; Protein quality; Tryptophan; Tyrosine; Vitamins |
amino acid; branched chain amino acid; cyanocobalamin; iodine; iron; lipid; long chain fatty acid; mammalian target of rapamycin complex 1; phenylalanine; polar lipid; polyunsaturated fatty acid; prebiotic agent; probiotic agent; retinol; trace element; tryptophan; tyrosine; unclassified drug; vitamin D; zinc; fatty acid; kynurenine; mineral; brain development; child; cognition; emotion; human; infant; infant nutrition; intestine flora; macronutrient; nerve cell differentiation; nonhuman; nutritional support; protein intake; protein quality; Review; brain; cognitive aging; food; growth, development and aging; preschool child; quality of life; Brain; Child, Preschool; Cognition; Cognitive Aging; Emotions; Fatty Acids; Food; Gastrointestinal Microbiome; Humans; Infant; Kynurenine; Minerals; |
MDPI AG |
20726643 |
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33435231 |
Review |
Q1 |
1418 |
2497 |
|
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No records
|
72 |
Fitriana I., Setiati S., Rizal E.W., Istanti R., Rinaldi I., Kojima T., Akishita M., Azwar M.K. |
55486095900;14325991900;57223021639;23496653300;23475122400;55240575700;7004867426;57202798959; |
Malnutrition and depression as predictors for 30-day unplanned readmission in older patient: a prospective cohort study to develop 7-point scoring system |
2021 |
BMC Geriatrics |
21 |
1 |
256 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104539861&doi=10.1186%2fs12877-021-02198-7&partnerID=40&md5=38aa06ca8c7777764cff2096359b93e7 |
Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia; Clinical Epidemiology and Evidence Based Medicine Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan |
Fitriana, I., Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia; Setiati, S., Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia, Clinical Epidemiology and Evidence Based Medicine Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rizal, E.W., Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia; Istanti, R., Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia; Rinaldi, I., Clinical Epidemiology and Evidence Based Medicine Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kojima, T., Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Akishita, M., Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Azwar, M.K., Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia |
Background: Readmission is related to high cost, high burden, and high risk for mortality in geriatric patients. A scoring system can be developed to predict the readmission of older inpatients to perform earlier interventions and prevent readmission. Methods: We followed prospectively inpatients aged 60 years and older for 30 days, with initial comprehensive geriatric assessment (CGA) on admission in a tertiary referral centre. Patients were assessed with CGA tools consisting of FRAIL scale (fatigue, resistance, ambulation, illness, loss of weight), the 15-item Geriatric Depression Scale, Mini Nutritional Assessment short-form (MNA-SF), the Barthel index for activities of daily living (ADL), Charlson Comorbidity Index (CCI), caregiver burden based on 4-item Zarit Burden Index (ZBI), and cognitive problem with Abbreviated Mental Test (AMT). Demographic data, malignancy diagnosis, and number of drugs were also recorded. We excluded data of deceased patients and patients transferred to other hospitals. We conducted stepwise multivariate regression analysis to develop the scoring system. Results: Thirty-day unplanned readmission rate was 37.6 %. Among 266 patients, 64.7 % of them were malnourished, and 46.5 % of them were readmitted. About 24 % were at risk for depression or having depressed mood, and 53.1 % of them were readmitted. In multivariate analysis, nutritional status (OR 2.152, 95 %CI 1.151–4.024), depression status (OR 1.884, 95 %CI 1.071–3.314), malignancy (OR 1.863 95 %CI 1.005–3.451), and functional status (OR 1.584, 95 %CI 0.885–2.835) were included in derivation of 7 score system. The scoring system had maximum score of 7 and incorporated malnutrition (2 points), depression (2 points), malignancy (2 points), and dependent functional status (1 point). A score of 3 or higher suggested 82 % probability of readmission within 30 days following discharge. Area under the curve (AUC) was 0.694 (p = 0.001). Conclusions: Malnutrition, depression, malignancy and functional problem are predictors for 30-day readmission. A practical CGA-based 7 scoring system had moderate accuracy and strong calibration in predicting 30-day unplanned readmission for older patients. © 2021, The Author(s). |
Comprehensive geriatric assessment; Depression; Malnutrition; Predictive score; Readmission |
aged; daily life activity; depression; geriatric assessment; hospital readmission; human; malnutrition; middle aged; nutritional assessment; nutritional status; prospective study; risk factor; Activities of Daily Living; Aged; Depression; Geriatric Assessment; Humans; Malnutrition; Middle Aged; Nutrition Assessment; Nutritional Status; Patient Readmission; Prospective Studies; Risk Factors |
BioMed Central Ltd |
14712318 |
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33865312 |
Article |
Q1 |
1414 |
2506 |
|
|