271 |
Yonas E., Alwi I., Pranata R., Huang I., Lim M.A., Gutierrez E.J., Yamin M., Siswanto B.B., Virani S.S. |
57201987097;15055173800;57201973901;57208576645;57216039756;57200435964;23475706300;14422648800;6701757915; |
Effect of heart failure on the outcome of COVID-19 — A meta analysis and systematic review |
2021 |
American Journal of Emergency Medicine |
46 |
|
|
204 |
211 |
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43 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090893264&doi=10.1016%2fj.ajem.2020.07.009&partnerID=40&md5=08c8139ca7f811f915c445cf5c2e3f1c |
Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Department of Critical Care Medicine, Baptist Medical Center, Jacksonville, FL, United States; Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Michael E. DeBakey Veterans Affairs Medical Center & Baylor College of Medicine, Houston, TX, United States; Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, Indonesia, Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia |
Yonas, E., Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Alwi, I., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Huang, I., Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, Indonesia, Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Lim, M.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Gutierrez, E.J., Department of Critical Care Medicine, Baptist Medical Center, Jacksonville, FL, United States; Yamin, M., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Siswanto, B.B., Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Virani, S.S., Michael E. DeBakey Veterans Affairs Medical Center & Baylor College of Medicine, Houston, TX, United States |
Background: Several comorbidities have been associated with an increased risk of severity and mortality in coronavirus disease 2019 (COVID-19), including hypertension, diabetes, cerebrovascular disease, chronic kidney disease, and chronic obstructive pulmonary disease. Purpose: In this systematic review and meta-analysis, we attempted to investigate the association between heart failure (HF) and poor outcome in patients with COVID-19. Methods: We performed a systematic literature search from PubMed, EuropePMC, SCOPUS, Cochrane Central Database, and medRxiv with the search terms, “Heart failure” and “COVID-19”. The outcome of interest was mortality and poor prognosis (defined by incidence of severe COVID-19 infection, admission to ICU, and use of ventilator) in patients with preexisting heart failure with coronavirus disease. Results: We identified 204 potential articles from our search, and 22 duplicates were removed. After screening of the titles and abstracts of the remaining 182 articles we identified 92 potentially relevant articles. We excluded 74 studies due to the following reasons: four studies were systematic reviews, two studies were meta-analyses, three articles were literature reviews, and 65 articles did not report on the outcome of interest. Finally, we included the remaining 18 studies in our qualitative synthesis and meta-analysis. There were 21,640 patients from 18 studies. HF was associated with hospitalization in COVID19 HR was 2.37 [1.48, 3.79; p < 0.001], high heterogeneity [I2, 82%; p < 0.001]. HF was associated with a poor outcome demonstrated by an OR of 2.86 [2.07; 3.95; p < 0.001] high heterogeneity [I2, 80%; p < 0.001]. Patient with preexisting HF was associated with higher mortality OR of 3.46 [2.52, 4.75; p < 0.001] moderately high heterogeneity [I2, 77%; p < 0.001]. Conclusion: Patients with heart failure are at increased risk for hospitalization, poor outcome, and death from COVID-19. A significant difference in mortality between patients with and without heart failure was observed, patients with heart failure having a higher mortality. © 2020 Elsevier Inc. |
Coronavirus disease 2019; Heart failure; Poor outcomes |
apnea hypopnea index; Article; artificial ventilation; coronavirus disease 2019; heart failure; hospitalization; human; incidence; meta analysis; mortality; outcome assessment; prevalence; prognosis; questionnaire; risk factor; systematic review; comorbidity; global health; heart failure; pandemic; procedures; risk assessment; survival rate; Comorbidity; COVID-19; Global Health; Heart Failure; Humans; Pandemics; Risk Assessment; Risk Factors; SARS-CoV-2; Survival Rate |
W.B. Saunders |
07356757 |
|
33071085 |
Article |
Q1 |
725 |
6828 |
|
|
762 |
Gunarti D.R., Sukmawati D., Nasser M.K., Ikram T.A.Z., Pribawa R.N., Suryandari D.A. |
57196435346;55615650900;57225994342;57225992297;57225996674;6505763338; |
Rice bran supplement enhances gsh levels in testis and liver of carbon tetrachloride-induced rats [Pirinç kepeği takviyesi, karbon tetraklorürle İndüklenen sıçanların testis ve karaciğerinde gsh seviyelerini artırır] |
2021 |
Fabad Journal of Pharmaceutical Sciences |
46 |
2 |
|
129 |
138 |
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|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110108277&partnerID=40&md5=dcb45fa417f0982414baa1197be3c11f |
Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Gunarti, D.R., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sukmawati, D., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Nasser, M.K., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ikram, T.A.Z., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Pribawa, R.N., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Suryandari, D.A., Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
In the present study, the potency of rice bran as an antioxidant was examined. Rice bran is a by-product of the rice milling process, despite being a rich nutrient, it has limitations in food application. In this study, we used carbon tetrachloride-induced rats (CCl4) as a model of oxidative stress and examined the effect of extract IPB 3S rice bran supplement (RBS) on testis and liver endogenous antioxidant. The testis and liver were used as the representative organs which prone to exposure to reactive oxygen species (ROS). We used 150 and 300 mg.kg-1 Body weight (BW) of RBS. The Concentration of glutathione (GSH) in both organs was measured. All groups administered by RBS had significantly higher GSH levels compared to the CCl4 group, both in testis and liver. The dose of 300 mg.kg-1 BW RBS had a significantly higher GSH level in testis, while 150 mg.kg-1 VA RBS had a significantly higher GSH level in the liver tissue compared to the control group accordingly. Thus, the rice bran supplement enhances GSH levels in rat’s liver and testis which potentially has protective effects. © 2021 Society of Pharmaceutical Sciences of Ankara (FABAD). All rights reserved. |
Antioxidants; CCl4; Glutathione; IPB 3S; Liver; Rice bran; Testis |
antioxidant; carbon tetrachloride; glutathione; plant extract; reactive oxygen metabolite; rice bran extract; unclassified drug; animal experiment; animal model; animal tissue; Article; body weight; cell protection; comparative study; controlled study; diet supplementation; drug effect; drug potency; liver tissue; male; nonhuman; oxidative stress; rat; rice bran; testis |
Society of Pharmaceutical Sciences of Ankara (FABAD) |
13004182 |
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Article |
Q3 |
150 |
23158 |
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