No records
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383 |
Pranata R., Henrina J., Yonas E., Putra I.C.S., Cahyadi I., Lim M.A., Munawar D.A., Munawar M. |
57201973901;57218482646;57201987097;57222144236;57221688594;57216039756;56470745000;16747447600; |
BMI and atrial fibrillation recurrence post catheter ablation: A dose-response meta-analysis |
2021 |
European Journal of Clinical Investigation |
51 |
6 |
e13499 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101961208&doi=10.1111%2feci.13499&partnerID=40&md5=72dba8a2a9279126fd9e453324e6df70 |
Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Binawaluya Cardiac Center, Jakarta, Indonesia; Balaraja General Hospital, Tangerang, Indonesia; Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Syamsudin SH General Hospital, Sukabumi, Indonesia; Pasar Rebo General Hospital, Jakarta, Indonesia; Department of Cardiology, Lyell McEwin Hospital, University of Adelaide, Elizabeth Vale, Australia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Binawaluya Cardiac Center, Jakarta, Indonesia; Henrina, J., Balaraja General Hospital, Tangerang, Indonesia; Yonas, E., Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Putra, I.C.S., Syamsudin SH General Hospital, Sukabumi, Indonesia; Cahyadi, I., Pasar Rebo General Hospital, Jakarta, Indonesia; Lim, M.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Munawar, D.A., Department of Cardiology, Lyell McEwin Hospital, University of Adelaide, Elizabeth Vale, Australia, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Munawar, M., Binawaluya Cardiac Center, Jakarta, Indonesia, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Introduction: The evidence on the association between obesity and atrial fibrillation (AF) recurrence was equivocal. We aimed to evaluate the dose-response relationship between body mass index (BMI) and AF recurrence and adverse events. Methods: A systematic literature search was conducted using PubMed, Europe PMC, EBSCO, ProQuest and Cochrane Library. Obesity was defined as BMI ≥28 kg/m2. The primary outcome was AF recurrence, and the secondary outcome was adverse events. Adverse events were defined as procedure-related complications and cardio-cerebrovascular events. Results: There were a total of 52,771 patients from 20 studies. Obesity was associated with higher AF recurrence (Odds ratio [OR] 1.30 [95% confidence interval [CI] 1.16-1.47], P <.001; I2: 72.7%) and similar rate of adverse events (OR 1.21 [95% CI 0.87-1.67], P =.264; I2: 23.9%). Meta-regression showed that the association varies by age (coefficient: −0.03, P =.024). Meta-analysis of highest versus lowest BMI showed that the highest group had higher AF recurrence (OR 1.37 [95% CI 1.18-1.58], P <.001; I2: 64.9%) and adverse events (OR 2.02 [95% CI 1.08-3.76], P =.028; I2: 49.5%). The linear association analysis for AF recurrence was not significant (P =.544). The dose-response relationship for BMI and AF recurrence was nonlinear (pnonlinearity < 0.001), the curve became steeper at 30-35 kg/m2. For adverse events, an increase of 1% for every 1 kg/m2 increase in BMI (OR 1.01 [95% CI 1.00-1.02], P =.001), the relationship was nonlinear (pnonlinearity = 0.001). Conclusion: Obesity was associated with higher AF recurrence in patients undergoing catheter ablation. High BMI might be associated with a higher risk for adverse events. PROSPERO ID: CRD42020198787. © 2021 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd |
arrhythmia; Atrial Fibrillation; catheter ablation; obesity; pulmonary vein isolation |
anticoagulant agent; warfarin; adult; adverse event; age; aged; Article; atrial fibrillation; body mass; cardiovascular disease; catheter ablation; cerebrovascular disease; female; high risk patient; human; male; meta analysis; middle aged; obesity; outcome assessment; recurrence risk; systematic review; atrial fibrillation; body mass; obesity; recurrent disease; severity of illness index; Atrial Fibrillation; Body Mass Index; Catheter Ablation; Humans; Obesity; Overweight; Recurrence; Severity of Illness Index |
John Wiley and Sons Inc |
00142972 |
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33544873 |
Article |
Q1 |
1164 |
3461 |
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460 |
Darmaputra D.C., Zaman F.Y., Khu Y.L., Nagalingam V., Liew D., Aung A.K. |
57223041347;57208759841;57208757691;57215386437;7003970080;55117996600; |
Cost-analysis of opportunistic influenza vaccination in general medical inpatients |
2021 |
Internal Medicine Journal |
51 |
4 |
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591 |
595 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104572736&doi=10.1111%2fimj.15270&partnerID=40&md5=6be726bbda46f6b4342a09dd962a3b11 |
Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; Department of General Medicine, The Alfred Hospital, Melbourne, VIC, Australia |
Darmaputra, D.C., Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; Zaman, F.Y., Department of General Medicine, The Alfred Hospital, Melbourne, VIC, Australia; Khu, Y.L., Department of General Medicine, The Alfred Hospital, Melbourne, VIC, Australia; Nagalingam, V., Department of General Medicine, The Alfred Hospital, Melbourne, VIC, Australia; Liew, D., School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia, Department of General Medicine, The Alfred Hospital, Melbourne, VIC, Australia; Aung, A.K., School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia, Department of General Medicine, The Alfred Hospital, Melbourne, VIC, Australia |
Influenza vaccination is an important preventative health measure in the elderly and those with medical comorbidities. It has been shown to reduce hospitalisations, cardiovascular and respiratory complications. A significant proportion of patients admitted to general medicine are eligible for opportunistic inpatient influenza vaccination. This study explores the cost-effectiveness of such a strategy in reducing subsequent healthcare utilisation costs. © 2021 Royal Australasian College of Physicians |
cost-analysis; elderly; influenza; inpatient; vaccination |
aged; article; cost effectiveness analysis; health care utilization; hospital patient; human; influenza vaccination; cost benefit analysis; hospital patient; hospitalization; influenza; vaccination; influenza vaccine; Aged; Cost-Benefit Analysis; Hospitalization; Humans; Influenza Vaccines; Influenza, Human; Inpatients; Vaccination |
Blackwell Publishing |
14440903 |
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33890379 |
Article |
Q3 |
596 |
8475 |
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No records
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235 |
Widaty S., Menaldi S.L., Rihatmadja R., Miranda E., Marissa M., Kekalih A., Friska D., Oktarina C., Surya D. |
57208261546;57192918198;56427016700;57208259598;57210795916;55633562200;57202805330;57208263598;57210797458; |
Involvement of non-medical personnel in management of scabies at a boarding school in Indonesia |
2021 |
Southeast Asian Journal of Tropical Medicine and Public Health |
52 |
4 |
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527 |
537 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119906461&partnerID=40&md5=3b9a6a331f595bc79905a0e28fbc7d70 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Widaty, S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Menaldi, S.L., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Rihatmadja, R., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Miranda, E., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Marissa, M., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Kekalih, A., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Friska, D., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Oktarina, C., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Surya, D., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia |
One of the most common neglected tropical skin diseases in Indonesia is scabies, commonly associated with overcrowding, poor hygiene and poor nutritional status. Boarding schools are at risk of harboring infected populations. As recurrence is common, non-medical personnel need to be involved in management of scabies. This study aimed to investigate how non-medical personnel, in this case, the boarding school teachers, could manage scabies in a boarding school in Indonesia. We trained the teachers using the education module for early scabies detection approach, namely DeSkab program, to be able to identify three major signs of scabies in the students. Impact of this approach was evaluated in 2017 and 2018 at a religious boarding school in Bogor, Indonesia involving 127 and 202 students, consecutively. An education module was given to 16 boarding school teachers expecting them to be able to examine students prior to school admission and before and after mid-semester break. Teachers’ knowledge increased significantly after the training (p <0.001). This knowledge improvement is an important basis for teachers as non-medical personnel to implement independent scabies monitoring process during the educational year to find students with suspected scabies. Those suspected scabies students were directly referred to nearby public health clinic and treated with 5% permethrin and re-treated one week later. Prevalence of scabies decreased from 76% in 2017 to 49% in 2018 in 69 students who can be followed-up in two consecutive years (p-value = 0.014). In conclusion, involvement of non-medical personnel is an essential and effective strategy to improve management of scabies. © 2021, SEAMEO TROPMED Network. All rights reserved. |
Boarding school; DeSkab; Non-medical personnel; Prevention; Scabies |
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SEAMEO TROPMED Network |
01251562 |
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Article |
Q4 |
214 |
18533 |
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334 |
Yasmon A., Agnes A., Febriani R., Kusumaningrum A., Andriansjah, Sudarmono P. |
41462004500;57352939000;57212580873;57211641695;57352939200;6507855437; |
Identification of nontuberculous mycobacteria (Ntm) species isolated from the sputum, skin and soft tissue of patients in Jakarta, Indonesia |
2021 |
Southeast Asian Journal of Tropical Medicine and Public Health |
52 |
5 |
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644 |
650 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119897125&partnerID=40&md5=fa2f76f9076156267a3d1d05310fb824 |
Department of Microbiology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Yasmon, A., Department of Microbiology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Agnes, A., Department of Microbiology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Febriani, R., Department of Microbiology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kusumaningrum, A., Department of Microbiology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Andriansjah, Department of Microbiology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sudarmono, P., Department of Microbiology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Knowing the species of nontuberculous mycobacteria (NTM) causing disease in a patient population can guide empiric treatment. In this study we aimed to determine the species of NTM causing disease in a selected patient population in Indonesia in order to guide empiric treatment. We retrospectively reviewed the records of all patients treated at 5 hospitals in Jakarta, Indonesia, diagnosed with NTM infection during January 2018-December 2019. The inclusion criterion for study subjects was having a positive test for NTM and the exclusion criterion was having a positive culture for Mycobacterium tuberculosis complex. Study subjects were confirmed to have NTM by a MPT64 rapid test. The species of NTM were identified by DNA sequencing of Mycobacterium 16S rRNA. A total of 15 patients were determined to have NTM at the study institutions during the study period, 53% male. The average age of study subjects was 45 (range: 4-83) years. The NTM positive specimens were obtained from the sputum (n = 5), skin and soft tissue biopsies (n = 5), and lymphoid tissue biopsies (n = 5). Of the 15 study subjects, 8 (53%) had M. abscessus, 5 (33%) had M. intracellulare, 1 (7%) had M. avium and 1 (7%) had M. cookii. Of the 5 NTM isolates from the sputum, 3 isolates were M. abscessus, 1 isolate was M. intracellulare and 1 isolate was M. Cookii. Of the 5 NTM isolates from skin and soft biopsies, 3 isolates were M. abscessus and the other 2 isolates were M. intracellulare. Of the 5 NTM isolates from lymphoid tissue biopsies, 2 isolates were M. abscessus, 2 isolates were M. intracellulare and 1 isolate was M. Avium. In our study, the most common NTIM isolate was M. abscessus. Empiric treatment of NTM in the study population should include coverage of M. abscessus. Further studies with larger numbers of subjects from multiple institutions are needed to determine if these findings hold true for other parts of Indonesia. © 2021, SEAMEO TROPMED Network. All rights reserved. |
Lymphoid; Mycobacterium; NTM; Skin and soft; Sputum |
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SEAMEO TROPMED Network |
01251562 |
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Article |
Q4 |
214 |
18533 |
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709 |
Ayu Asri Prima Dewi A.A., Antarianto R.D., Pawitan J.A. |
57268721600;57190862806;6508348067; |
Characterization of indonesia decellularized liver cubes scaffold using scanning electron microscopy |
2021 |
Journal of Biomimetics, Biomaterials and Biomedical Engineering |
52 |
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38 |
46 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115446740&doi=10.4028%2fwww.scientific.net%2fJBBBE.52.38&partnerID=40&md5=c7fc1ea62d3680df39cd8c77bf963ba1 |
Master Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Central Jakarta, 10430, Indonesia; Department of Histology, Faculty of Medicine, Warmadewa University, Jl. Terompong 24 Tanjung Bungkak, Denpasar, Bali, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Central Jakarta, 10430, Indonesia; Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Central Jakarta, 10430, Indonesia; Integrated Stem Cell Technology Service Unit, Cipto Mangunkusumo National General Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia |
Ayu Asri Prima Dewi, A.A., Master Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Central Jakarta, 10430, Indonesia, Department of Histology, Faculty of Medicine, Warmadewa University, Jl. Terompong 24 Tanjung Bungkak, Denpasar, Bali, Indonesia; Antarianto, R.D., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Central Jakarta, 10430, Indonesia, Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Central Jakarta, 10430, Indonesia; Pawitan, J.A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Central Jakarta, 10430, Indonesia, Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Central Jakarta, 10430, Indonesia, Integrated Stem Cell Technology Service Unit, Cipto Mangunkusumo National General Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia |
Liver biological scaffold was developed in order to resemble native liver tissue environment. It can be achieved by decellularizing native liver tissue that will remove cells and preserve extracellular matrix (ECM). Furthermore, ECM fibers are arranged in a special pattern, which affect liver cell polarity and topography that are important for cells’ implantation, proliferation and differentiation. Therefore, the aim of this study was to evaluate liver cube scaffold topography that was decellularized with fixed multiple sites syringe injection (Indonesia patent number: S00201907930). Rat liver cubes (n=3) underwent decellularization with Ethylene Glycol Tetraacetic Acid (EGTA) immersion and increased Sodium Dodecyl Sulfate (SDS) concentrations using previous multiple sites syringe injection protocol study. Deoxyribonucleic Acid (DNA) concentrations were measured to confirm less DNA materials remaining in scaffolds. Scanning Electron Microscope (SEM) analysis of scaffolds were conducted for topographic characterization compared to undecellularized liver control. Molecular analysis of DNA concentration showed complete removal of DNA material. SEM analysis gave appearance of intact liver cube scaffold microarchitecture. Liver cubes decellularization using multiple sites syringe injection showed good topographic liver scaffold characterization. © 2021 Trans Tech Publications Ltd, Switzerland. |
Liver biological scaffold; Liver cube tissue; Liver decellularization; Multiple site syringe injection; Scanning electron microscope |
Cytology; DNA; Ethylene; Ethylene glycol; Geometry; Scaffolds (biology); Sodium dodecyl sulfate; Sulfur compounds; Syringes; Tissue; Acid concentrations; Biological scaffolds; Decellularization; Extracellular matrices; Indonesia; Liver biological scaffold; Liver cube tissue; Liver decellularization; Liver tissue; Multiple site syringe injection; Scanning electron microscopy |
Trans Tech Publications Ltd |
22969837 |
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Article |
Q4 |
183 |
20493 |
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710 |
Putrantyo I., Anilbhai N., Vanjani R., De Vega B. |
57268843400;57268843500;57268728700;57222467939; |
Tantalum as a novel biomaterial for bone implant: A literature review |
2021 |
Journal of Biomimetics, Biomaterials and Biomedical Engineering |
52 |
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55 |
65 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115443615&doi=10.4028%2fwww.scientific.net%2fJBBBE.52.55&partnerID=40&md5=23de679861db060839b35e7a1cc36b26 |
Division of Surgery and Interventional Science, University College London, Royal Free Hospital Campus, London, United Kingdom; Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Cell & Tissue Bank, Dr Soetomo General Hospital, Surabaya, Indonesia |
Putrantyo, I., Division of Surgery and Interventional Science, University College London, Royal Free Hospital Campus, London, United Kingdom, Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Anilbhai, N., Division of Surgery and Interventional Science, University College London, Royal Free Hospital Campus, London, United Kingdom; Vanjani, R., Division of Surgery and Interventional Science, University College London, Royal Free Hospital Campus, London, United Kingdom; De Vega, B., Division of Surgery and Interventional Science, University College London, Royal Free Hospital Campus, London, United Kingdom, Cell & Tissue Bank, Dr Soetomo General Hospital, Surabaya, Indonesia |
Titanium (Ti) has been used in metallic implants since the 1950s due to various biocompatible and mechanical properties. However, due to its high Young’s modulus, it has been modified over the years in order to produce a better biomaterial. Tantalum (Ta) has recently emerged as a new potential biomaterial for bone and dental implants. It has been reported to have better corrosion resistance and osteo-regenerative properties as compared to Ti alloys which are most widely used in the bone-implant industry. Currently, Tantalum cannot be widely used yet due to its limited availability, high melting point, and high-cost production. This review paper discusses various manufacturing methods of Tantalum alloys, including conventional and additive manufacturing and also discusses their drawbacks and shortcomings. Recent research includes surface modification of various metals using Tantalum coatings in order to combine bulk material properties of different materials and the porous surface properties of Tantalum. Design modification also plays a crucial role in controlling bulk properties. The porous design does provide a lower density, wider surface area, and more immense specific strength. In addition to improved mechanical properties, a porous design could also escalate the material's biological and permeability properties. With current advancement in additive manufacturing technology, difficulties in processing Tantalum could be resolved. Therefore, Tantalum should be considered as a serious candidate material for future bone and dental implants. © 2021 Trans Tech Publications Ltd, Switzerland. |
Bone implant; Porous metal; Porous structure; Surface coating; Tantalum |
3D printers; Additives; Biocompatibility; Coatings; Corrosion resistant alloys; Dental alloys; Dental prostheses; Mechanical permeability; Metal implants; Porosity; Tantalum alloys; Titanium alloys; Bone implant; High costs; High melting point; Literature reviews; Metallic implants; Porous metal; Porous structures; Property; Surface coatings; Titanium (alloys); Corrosion resistance |
Trans Tech Publications Ltd |
22969837 |
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Article |
Q4 |
183 |
20493 |
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No records
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432 |
Aitken R.J., Curry B.J., Shokri S., Pujianto D.A., Gavriliouk D., Gibb Z., Whiting S., Connaughton H.S., Nixon B., Salamonsen L.A., Baker M.A. |
7201959888;56908506100;8856710600;8745734300;56926729700;36650800200;55363694400;55488741500;34571659200;7005800278;57201355280; |
Evidence that extrapancreatic insulin production is involved in the mediation of sperm survival |
2021 |
Molecular and Cellular Endocrinology |
526 |
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111193 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101239641&doi=10.1016%2fj.mce.2021.111193&partnerID=40&md5=dd3268ec7434c8487b5f42a0d81d0e4a |
Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia; Hunter Medical Research Institute, New Lambton HeightsNSW 2305, Australia; Department of Anatomical Sciences, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran; Department of Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Family Fertility Centre, Ashford Specialist CentreSA 5035, Australia; Hudson Institute of Medical Research, Centre for Reproductive Health, Monash UniversityVIC 3168, Australia |
Aitken, R.J., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia, Hunter Medical Research Institute, New Lambton HeightsNSW 2305, Australia; Curry, B.J., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia; Shokri, S., Department of Anatomical Sciences, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran; Pujianto, D.A., Department of Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Gavriliouk, D., Family Fertility Centre, Ashford Specialist CentreSA 5035, Australia; Gibb, Z., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia; Whiting, S., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia; Connaughton, H.S., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia; Nixon, B., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia, Hunter Medical Research Institute, New Lambton HeightsNSW 2305, Australia; Salamonsen, L.A., Hudson Institute of Medical Research, Centre for Reproductive Health, Monash UniversityVIC 3168, Australia; Baker, M.A., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia, Hunter Medical Research Institute, New Lambton HeightsNSW 2305, Australia |
Evidence is presented for expression of the insulin receptor on the surface of mammalian spermatozoa as well as transcripts for the receptor substrate adaptor proteins (IRS1-4) needed to mediate insulin action. Exposure to this hormone resulted in insulin receptor phosphorylation (pTyr972), activation of AKT (pSer473) and the stimulation of sperm motility. Intriguingly, the male germ line is also shown to be capable of generating insulin, possessing the relevant mRNA transcript and expressing strong immunocytochemical signals for both insulin and C-peptide. Insulin could be released from the spermatozoa by sonication in a concentration-dependent manner but was not secreted in response to glucose, fructose or stimulation with progesterone. However, insulin release could be induced by factors present in human uterine lavages. Furthermore, the endometrium was also shown to possess the machinery for insulin production and action (mRNA, insulin, C-peptide, proprotein convertase and insulin receptor), releasing insulin into the uterine lumen prior to ovulation. These studies emphasize the fundamental importance of extra-pancreatic insulin in regulating the reproductive process, particularly in the support of spermatozoa on their perilous voyage to the site of fertilization. © 2021 Elsevier B.V. |
AKT-1; Apoptosis; Insulin; Motility; Spermatozoa |
C peptide; fructose; glucose; insulin; insulin receptor; messenger RNA; progesterone; proprotein convertase 1; proprotein convertase 3; protein kinase B; serine proteinase; unclassified drug; C peptide; insulin; insulin receptor; insulin receptor substrate; isoprotein; adult; animal tissue; Article; controlled study; enzyme activation; female; fertilization; human; immunocytochemistry; insulin release; male; mouse; nested polymerase chain reaction; nonhuman; ovulation; protein function; protein phosphorylation; protein RNA binding; real time polymerase chain reaction; spermatozoon motility; animal; biosynthesis; cell survival; cytology; endometrium; epithelium; germ cell; mammal; metabolism; pancreas; rat; spermatozoon; uterus; Animals; C-Peptide; Cell Survival; Endometrium; Epithelium; Fe |
Elsevier Ireland Ltd |
03037207 |
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33610643 |
Article |
Q1 |
1296 |
2909 |
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No records
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125 |
Hermansyah T.A., Ginanjar E., Putri V.H. |
57428569000;23472616600;57428569100; |
Elevation of Cardiac Biomarkers in COVID-19 As a Major Determinant for Mortality: A Systematic Review |
2021 |
Acta medica Indonesiana |
53 |
4 |
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385 |
396 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123568570&partnerID=40&md5=0047595d5dd32380033c242e7c79fe4c |
Faculty of Medicine Universitas IndonesiaJakarta, Indonesia |
Hermansyah, T.A., Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Ginanjar, E.; Putri, V.H. |
BACKGROUND: This study aimed to summarize the prognosis of Corona Virus Disease 2019 (COVID-19) patients with elevated troponin and N-terminal pro brain natriuretic peptide (NT-proBNP) levels and demonstrate the involvement of myocardial injury as a complication in COVID-19. METHODS: A systematic literature search was performed using several databases (PubMed, MEDLINE, PROQUEST and SCOPUS ) for studies published up to August 2020. Observational studies about the mortality outcome of COVID-19 patients who experienced cardiac injury, as defined by the elevation of serum levels of troponin, brain natriuretic peptide (BNP), with NT-proBNP or only BNP or only NT-proBNP, were included. In addition, a critical appraisal was conducted for all included studies using the Critical Appraisal for Prognostic Studies checklist published by the Centre for Evidence-Based Medicine by the University of Oxford. RESULTS: Seven retrospective observational studies fulfilled the inclusion criteria. This study found that there is a higher risk of death in COVID 19 patients with higher levels of troponin and NT-proBNP, indicating the importance of these biomarkers as determinant factors to predict in-hospital deaths. CONCLUSION: Based on the analysis, elevation of troponin and NT-proBNP levels plays an essential role in determining the patient prognosis because it is shown to be associated with in-hospital mortality. This also supports the involvement of myocardial injury as a prominent fatal complication in COVID-19. |
BNP; COVID-19; myocardial injury; NT-proBNP; prognostic factors; troponin |
biological marker; brain natriuretic peptide; peptide fragment; pro-brain natriuretic peptide (1-76); troponin; blood; human; mortality; observational study; prognosis; retrospective study; Biomarkers; COVID-19; Humans; Natriuretic Peptide, Brain; Observational Studies as Topic; Peptide Fragments; Prognosis; Retrospective Studies; SARS-CoV-2; Troponin |
NLM (Medline) |
01259326 |
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35027485 |
Article |
Q3 |
321 |
14162 |
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126 |
Saldi S.R.F., Safitri E.D., Setiati S., Ranakusuma R.W., Marsigit J., Azwar M.K., Astuti P., Sari C.Y.I., Istanti R., Yulianti M., Rumende C.M., Yunihastuti E., Susilo A., Harimurti K., Liastuti L.D., Trimartani T., Restuti R.D., Syam A.F. |
55201904000;57195934356;14325991900;57189729404;57218912589;57202798959;57436688300;57218292263;23496653300;57216405885;14325966300;57221273925;57217867079;23473513200;57204676441;57428529000;55261428300;8443384400; |
Prognostic Scoring System for Mortality of Hospitalized COVID-19 Patients in Resource-Limited Settings: A Multicenter Study from COVID-19 Referral Hospitals |
2021 |
Acta medica Indonesiana |
53 |
4 |
|
407 |
415 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123568238&partnerID=40&md5=e5654832599ee37e6d1d6dad0e5cc30c |
Clinical Epidemiology and Evidence-Based Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo HospitalJakarta, Indonesia |
Saldi, S.R.F., Clinical Epidemiology and Evidence-Based Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo HospitalJakarta, Indonesia; Safitri, E.D.; Setiati, S.; Ranakusuma, R.W.; Marsigit, J.; Azwar, M.K.; Astuti, P.; Sari, C.Y.I.; Istanti, R.; Yulianti, M.; Rumende, C.M.; Yunihastuti, E.; Susilo, A.; Harimurti, K.; Liastuti, L.D.; Trimartani, T.; Restuti, R.D.; Syam, A.F. |
BACKGROUND: Many studies identified the risk factors and prognostic factors related to in-hospital COVID-19 mortality using sophisticated laboratory tests. Cost and the availability of supporting blood tests may be problematic in resource-limited settings. This multicenter cohort study was conducted to assess the factors associated with mortality of COVID-19 patients aged 18 years and older, based on history taking, physical examination, and simple blood tests to be used in resource-limited settings. METHODS: The study was conducted between July 2020 and January 2021 in five COVID-19 referral hospitals in Indonesia. Among 1048 confirmed cases of COVID-19, 160 (15%) died during hospitalization. RESULTS: Multivariate analysis showed eight predictors of in-hospital mortality, namely increased age, chronic kidney disease, chronic obstructive pulmonary disease, fatigue, dyspnea, altered mental status, neutrophil-lymphocyte ratio (NLR) ≥ 5.8, and severe-critical condition. This scoring system had an Area-under-the-curve (AUC) of 84.7%. With cut-off score of 6, the sensitivity was 76.3% and the specificity was 78.2%. CONCLUSION: The result of this practical prognostic scoring system may be a guide to decision making of physicians and help in the education of family members related to the possible outcome. |
COVID-19; mortality; predictive score; prognostic; resource-limited settings |
clinical trial; comorbidity; health care planning; hospital; hospital mortality; human; mortality; multicenter study; patient referral; prognosis; retrospective study; sensitivity and specificity; Comorbidity; COVID-19; Health Resources; Hospital Mortality; Hospitals; Humans; Prognosis; Referral and Consultation; Retrospective Studies; SARS-CoV-2; Sensitivity and Specificity |
NLM (Medline) |
01259326 |
|
35027487 |
Article |
Q3 |
321 |
14162 |
|
|
127 |
Yunihastuti E. |
57221273925; |
Prioritizing Health Care Workers Safety: The International Year of Health and Care Workers 2021 |
2021 |
Acta medica Indonesiana |
53 |
4 |
|
371 |
373 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123567858&partnerID=40&md5=6b031d0156ba2c68eb828650dd45d00d |
Division of Allergy and Clinical Immunology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
Yunihastuti, E., Division of Allergy and Clinical Immunology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
Healthcare workers pose a substantial risk of acquiring COVID-19 infection during their daily works. We have seen various conditions during the pandemic, such as limited adequate personal protective equipment (PPE), accurate diagnostic tests, lack of information regarding disease management, unsupportive work environment, and excessive workload, increased the number of HCWs-infected COVID-19. Compared to the general population, the risk of COVID-19 infection was several-fold higher in HCWs.Employers and health care workers both should share the responsibility to prevent occupationally acquired infections and avoid causing harm to patients by taking reasonable precautions to prevent vaccine-preventable disease transmission.This year, WHO has launched a year-long campaign under the theme -protect, invest, together'. It highlights the urgent need to invest in health care workers, not only during COVID-19. We need to ensure that all health care workers are supported, protected, motivated, and equipped to deliver safe health care at all times, to provide a high-quality standard of care to the patients. |
COVID-19; healthcare workers; personal protective equipment; safety; vaccination |
health care personnel; human; occupational health; pandemic; protective equipment; World Health Organization; COVID-19; Health Personnel; Humans; Occupational Health; Pandemics; Personal Protective Equipment; World Health Organization |
NLM (Medline) |
01259326 |
|
35027483 |
Article |
Q3 |
321 |
14162 |
|
|