No records
|
195 |
Habiburrahman M., Lesmana E., Harmen F., Gratia N., Mirtha L.T. |
57320844200;57208440285;57288593800;57288763400;57193201450; |
The impact of sleep deprivation on work performance towards night-shift healthcare workers: An evidence-based case report |
2021 |
Acta Medica Philippina |
55 |
6 |
|
650 |
664 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116676334&doi=10.47895%2fAMP.V55I6.3157&partnerID=40&md5=279c9c6f812ba7d9e6cf09363847268d |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hospital of Universitas Indonesia, Depok, Indonesia |
Habiburrahman, M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Lesmana, E., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Harmen, F., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Gratia, N., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mirtha, L.T., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Hospital of Universitas Indonesia, Depok, Indonesia |
Background. Poor sleep and excessive fatigue among workers can reduce well-being and physical fitness. However, not many studies have mentioned how sleeping deprivation among night-shift healthcare workers impacted their work performance in multiple aspects. Method. We conducted an evidence-based case report (EBCR) of a night shift nurse who was worried about the impact of her sleep deprivation on her work performance in the future due to prior history of needle-stick injuries. We aimed to determine whether sleeping deprivation caused by regular night shifts leads to decreased work performance among night-shift healthcare workers by formulating a clinical question. Evidence was searched systematically using five major journal databases (Proquest, EBSCO-Host, PubMed, ScienceDirect, and Cochrane) and was assessed thoroughly using inclusion and exclusion criteria. Results. Eleven eligible studies were obtained with a medium level of evidence (III-IV), three systematic reviews with meta-analyses (SR-MA), three SR without MA, and five observational studies. All of them were analyzed and critically appraised using Oxford Evidence-Based Medicine and Joanna Briggs Institute tools. We found that reduced quantity and quality of sleep impacted all dimensions of work performance among healthcare professionals, be it in task performance (e.g., skill proficiency), contextual performance (e.g., communication skill and mental health issues), and patient and health worker safety (accident and medication error). It could also encourage counterproductive work behavior, such as absenteeism. Furthermore, sleep deprivation changes circadian rhythms, causing decreased information processing and affective recognition functions in some vital brain areas, ultimately affecting several work dimensions. Conclusion. In conclusion, stakeholders need to adjust proper shift scheduling for health care workers, practice sleep hygiene, maintain physical fitness, and consume nutritional food, positively correlated to health and productivity. © 2021 University of the Philippines Manila. All rights reserved. |
Evidence-based medicine; Healthcare worker; Night shift; Sleep deprivation; Work performance |
|
University of the Philippines Manila |
00016071 |
|
|
Article |
Q4 |
128 |
25603 |
|
|
196 |
Alie I.R., Andriantoro H., Timan I.S., Sulistomo A.W., Illyas E.I., Mansyur M. |
57288933200;55037171500;6602793366;57024018500;57288423500;37085506800; |
Potency biomarker effect of endothelial microparticles (emps) for early prediction of cardiovascular risk in shift worker nurses |
2021 |
Acta Medica Philippina |
55 |
6 |
|
616 |
620 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116671512&doi=10.47895%2fAMP.V55I6.3142&partnerID=40&md5=10ceaf9c58aabc0ce93083d831644fe1 |
Program of Universitas Indonesia; Department of Cardiology and Vascular Faculty of Medicine, Universitas Indonesia; Department of Pathology Clinic, Faculty of Medicine, Universitas Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia; Department of Physiology, Faculty of Medicine, Universitas Indonesia |
Alie, I.R., Program of Universitas Indonesia; Andriantoro, H., Department of Cardiology and Vascular Faculty of Medicine, Universitas Indonesia; Timan, I.S., Department of Pathology Clinic, Faculty of Medicine, Universitas Indonesia; Sulistomo, A.W., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia; Illyas, E.I., Department of Physiology, Faculty of Medicine, Universitas Indonesia; Mansyur, M., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia |
Objectives. Shift work results in changing worker's behavior, food, and sleep patterns, which can cause circadian rhythm disturbance, which is a cardiovascular risk. Until now, a biomarker of early prediction of cardiovascular risk on shift workers is still not developed. This study aimed to assess the cardiovascular risk of shift worker nurses by detecting endothelial microparticles (EMPs). Methods. This longitudinal study compared six shift nurses and five non-shift nurses by measuring the EMPs using antigen CD31+ flow cytometry. All met the inclusion criteria consisting of 28 blood samples followed in one week shift. Results. EMPs among non-shift nurses were below 200 μL. However, shift nurses' EMPs increased above 200 μL with Man-Whitney U p = 0.000 on days 4 and 7 following a one shift per week schedule. Conclusion. There was an increase in shift workers' endothelial microparticles (EMP) which was a sign of cardiovascular risk. © 2021 University of the Philippines Manila. All rights reserved. |
Cardiovascular risk; CD31+; Endothelial microparticles (EMPs); Nurse; Shift work |
|
University of the Philippines Manila |
00016071 |
|
|
Article |
Q4 |
128 |
25603 |
|
|
197 |
Permata T.B.M., Sato H., Gu W., Kakoti S., Uchihara Y., Yoshimatsu Y., Sato I., Kato R., Yamauchi M., Suzuki K., Oike T., Tsushima Y., Gondhowiardjo S., Ohno T., Yasuhara T., Shibata A. |
57197808751;55697961900;57211574572;57197814645;57221723636;57284438600;57285097100;57204087445;8307897300;57376271900;36453136000;57284002500;6508327402;35395665700;56562637100;8323572900; |
High linear energy transfer carbon-ion irradiation upregulates PD-L1 expression more significantly than X-rays in human osteosarcoma U2OS cells |
2021 |
Journal of Radiation Research |
62 |
5 |
|
773 |
781 |
|
2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115918333&doi=10.1093%2fjrr%2frrab050&partnerID=40&md5=a1550b83230aa8ab90277d2716e9a556 |
Department of Radiation Oncology, Gunma University, Gunma, Maebashi, 371-8511, Japan; Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Gunma University Heavy IonMedical Center, Gunma, Maebashi, 371-8511, Japan; Gunma University Initiative for Advanced Research (GIAR), Gunma University, Gunma, Maebashi, 371-8511, Japan; Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School OfMedicine, Gunma, Maebashi, 371-8511, Japan; Laboratory of Molecular Radiology, Center for Disease Biology and Integrative Medicine, Graduate School OfMedicine, The University OfTokyo, Bunkyo-ku, Tokyo, 113-8655, Japan; Department of Radiation Biology and Protection, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, 852-8523, Japan; Department of Radiation Medical Science, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, 852-8523, Japan |
Permata, T.B.M., Department of Radiation Oncology, Gunma University, Gunma, Maebashi, 371-8511, Japan, Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Sato, H., Department of Radiation Oncology, Gunma University, Gunma, Maebashi, 371-8511, Japan, Gunma University Heavy IonMedical Center, Gunma, Maebashi, 371-8511, Japan; Gu, W., Gunma University Initiative for Advanced Research (GIAR), Gunma University, Gunma, Maebashi, 371-8511, Japan, Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School OfMedicine, Gunma, Maebashi, 371-8511, Japan; Kakoti, S., Department of Radiation Oncology, Gunma University, Gunma, Maebashi, 371-8511, Japan, Gunma University Initiative for Advanced Research (GIAR), Gunma University, Gunma, Maebashi, 371-8511, Japan; Uchihara, Y., Gunma University Initiative for Advanced Research (GIAR), Gunma University, Gunma, Maebashi, 371-8511, Japan; Yoshimatsu, Y., Gunma University Initiative for Advanced Research (GIAR), Gunma University, Gunma, Maebashi, 371-8511, Japan, Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School OfMedicine, Gunma, Maebashi, 371-8511, Japan; Sato, I., Gunma University Initiative for Advanced Research (GIAR), Gunma University, Gunma, Maebashi, 371-8511, Japan; Kato, R., Laboratory of Molecular Radiology, Center for Disease Biology and Integrative Medicine, Graduate School OfMedicine, The University OfTokyo, Bunkyo-ku, Tokyo, 113-8655, Japan; Yamauchi, M., Department of Radiation Biology and Protection, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, 852-8523, Japan; Suzuki, K., Department of Radiation Medical Science, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, 852-8523, Japan; Oike, T., Department of Radiation Oncology, Gunma University, Gunma, Maebashi, 371-8511, Japan; Tsushima, Y., Gunma University Initiative for Advanced Research (GIAR), Gunma University, Gunma, Maebashi, 371-8511, Japan; Gondhowiardjo, S., Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Ohno, T., Department of Radiation Oncology, Gunma University, Gunma, Maebashi, 371-8511, Japan, Gunma University Heavy IonMedical Center, Gunma, Maebashi, 371-8511, Japan; Yasuhara, T., Laboratory of Molecular Radiology, Center for Disease Biology and Integrative Medicine, Graduate School OfMedicine, The University OfTokyo, Bunkyo-ku, Tokyo, 113-8655, Japan; Shibata, A., Gunma University Initiative for Advanced Research (GIAR), Gunma University, Gunma, Maebashi, 371-8511, Japan |
Programmed death ligand 1 (PD-L1) expression on the surface of cancer cells affects the efficacy of anti-PD-1/PD-L1 immune checkpoint therapy. However, the mechanism underlying PD-L1 expression in cancer cells is not fully understood, particularly after ionizing radiation (IR). Here, we examined the impact of high linear energy transfer (LET) carbon-ion irradiation on the expression of PD-L1 in human osteosarcoma U2OS cells. We found that the upregulation of PD-L1 expression after high LET carbon-ion irradiation was greater than that induced by X-rays at the same physical and relative biological effectiveness (RBE) dose, and that the upregulation of PD-L1 induced by high LET carbon-ion irradiation was predominantly dependent on ataxia telangiectasia and Rad3-related (ATR) kinase activity. Moreover, we showed that the downstream signaling, e.g. STAT1 phosphorylation and IRF1 expression, was upregulated to a greater extent after high LET carbon-ion irradiation than X-rays, and that IRF1 upregulation was also ATR dependent. Finally, to visualize PD-L1 molecules on the cell surface in 3D, we applied immunofluorescence-based super-resolution imaging. The three-dimensional structured illumination microscopy (3D-SIM) analyses revealed substantial increases in the number of presented PD-L1 molecules on the cell surface after high LET carbon-ion irradiation compared with X-ray irradiation. © 2021 The Author(s) 2021. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology. |
anti-PD-1/PD-L1 therapy; DNA damage response; high linear energy transfer (LET) carbon-ion therapy; PD-L1 expression |
Carbon; Cell membranes; Cytology; Diseases; Ionizing radiation; Ions; Molecules; Oncology; Radiotherapy; Anti-PD-1/programmed death ligand 1 therapy; Carbon ion therapy; Carbon ions; DNA damage response; High linear energy transfer carbon-ion therapy; High linear energy transfers; Human osteosarcoma; Ions irradiation; Programmed death ligand 1 expression; Up-regulation; Energy transfer; 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one; 3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide; ATM protein; ATM protein, human; ATR protein, human; CD274 protein, human; interferon regulatory factor 1; IRF1 protein, human; messenger RNA; morpholine derivative; programmed death 1 ligand 1; pyrazine derivative; pyrone derivative; RNA; STAT1 protein; STAT1 protein, human; sulfone; tumor p |
Oxford University Press |
04493060 |
|
34196706 |
Article |
Q2 |
643 |
7838 |
|
|
198 |
Kartika R.W., Alwi I., Yunir E., Waspadji S., Suyatna F.D., Bardosono S., Immanuel S., Sungkar S., Rachmat J., Silalahi T., Reksodiputro M.H. |
57223447932;15055173800;36520254800;8678136400;56039633100;21933841000;57272979000;57016857300;6507225348;56275255400;35090488800; |
Efficacy of Combining Hyaluronic Acid and Platelet-Rich Fibrin in Diabetic Foot Ulcer |
2021 |
Jordan Journal of Biological Sciences |
14 |
3 |
|
607 |
611 |
|
1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115791952&partnerID=40&md5=76c1dc1bbdde331f901d412f6b6a83ba |
Doctoral Program in Medical Science Faculty of Medicine Universitas Indonesia, Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine Krida Wacana Christian University, Indonesia; Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Clinical Pharmacology, Faculty of Medicine Universitas Indonesia, Indonesia; Department of Clinical Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Thoracic Cardiac and Vascular Surgery, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine Krida Wacana Christian University, Jakarta, Indonesia; Department of Otorhinolaryngology, Facial Plastic Reconstructive Division, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Kartika, R.W., Doctoral Program in Medical Science Faculty of Medicine Universitas Indonesia, Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine Krida Wacana Christian University, Indonesia; Alwi, I., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Yunir, E., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Waspadji, S., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Suyatna, F.D., Department of Clinical Pharmacology, Faculty of Medicine Universitas Indonesia, Indonesia; Bardosono, S., Department of Clinical Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Immanuel, S., Department of Clinical Pathology, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sungkar, S., Department of Parasitology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rachmat, J., Department of Thoracic Cardiac and Vascular Surgery, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Silalahi, T., Department of Internal Medicine, Faculty of Medicine Krida Wacana Christian University, Jakarta, Indonesia; Reksodiputro, M.H., Department of Otorhinolaryngology, Facial Plastic Reconstructive Division, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Objectives: A chronic complication of type-2 diabetes mellitus (DMT-2) is Diabetic Foot Ulcer (DFU). The main treatment used in DFU is wound cleansing, followed by dressing the wound as a local control to increase tissue granulation and epithelialization. This study aims to compare the efficacy of the combination of Hyaluronic Acid with Platelet Rich Fibrin (HAPRF) and Platelet Rich Fibrin alone in DFU. Methods: We conducted a randomized controlled trial from July 2019 to April 2020. The study was approved by the Ethics Committee of the Faculty of Medicine of Universitas Indonesia ID 0855 / UN2.F1 / ETIK / 2018. Informed consent was obtained from the patients. This was a randomized clinical study to compare the efficacy of HAPRF and PRF in DFU one week post debridement. Twenty DFU samples were collected divided into 2 treatment groups: topical treatment using HAPRF compare with PRF alone. Assessment for wounds improvement was recorded using a digital camera 48 mega pixel with an accuracy of 0.1% on day-0, 3, 7, and 14. The results of the wound photographs were processed using ImageJ software. The granulation area (GA) and wound area (WA) were evaluated by IBM SPSS software v.20. The general data description was presented in median (range) value and parameter’s differences were conducted using Mann–Whitney test Results: The two treatment groups showed insignificant difference in characteristics between both group before intervention. The mean granulation width after two weeks of use HAPRF was 97.4% and PRF was 81.9%. Statistical analysis using Mann Whitney test showed granulation area of HAPRF group was significantly different compared with PRF group on day-3(p=0.047), day-7 ( p = 0.004) and day-14 ( p < 0.001). At the end of the wound healing process, the HAPRF group was significantly different compared with PRF group on Δ day 0−3 ( p=0.048), Δ day 0−7 ( p = 0.039), and Δ day 0−14 ( p = 0.023). Conclusions: HAPRF improves wound healing rate through increasing granulation tissue and epithelialization compared with PRF only in diabetic foot ulcer after 2 weeks post debridement compared to PRF. © 2021, Jordan Journal of Biological Sciences. All Rights Reserved. |
Delta Wound Area; Diabetic ulcer; Granulation Area; Hyaluronic Acid; Platelet Rich Fibrin |
|
Hashemite University |
19956673 |
|
|
Article |
Q3 |
216 |
18398 |
|
|
202 |
Rusdi N.K., Purwaningsih E.H., Hestiantoro A., Elya B., Kusmardi K. |
57211475250;57186723500;8743255100;14014224500;56966625300; |
In vivo antimammary tumor effects of soybean extract with targeted lunasin (ET-Lun) |
2021 |
Pharmacognosy Journal |
13 |
5 |
|
1269 |
1276 |
|
2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115297490&doi=10.5530%2fpj.2021.13.160&partnerID=40&md5=d96a1538654afeda0377ba6b0d8a5e38 |
Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. DR. Hamka, Jakarta, Indonesia; Department of Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department Obstetrics and Gynaecology, School of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Drug Development Research Cluster, Indonesian Medical Education and Reseach Institute, Universitas INDONESIA, Indonesia; Human Cancer Research Cluster, Indonesian Medical Education and Research Institute, Universitas INDONESIA, Indonesia |
Rusdi, N.K., Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. DR. Hamka, Jakarta, Indonesia; Purwaningsih, E.H., Department of Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Drug Development Research Cluster, Indonesian Medical Education and Reseach Institute, Universitas INDONESIA, Indonesia; Hestiantoro, A., Department Obstetrics and Gynaecology, School of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Elya, B., Department of Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Kusmardi, K., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Drug Development Research Cluster, Indonesian Medical Education and Reseach Institute, Universitas INDONESIA, Indonesia, Human Cancer Research Cluster, Indonesian Medical Education and Research Institute, Universitas INDONESIA, Indonesia |
Background/Objective: Lunasin is a peptide, consist of 44 amino acids which have anti-cancer, antioxidant, and anti-inflammatory activity. The price of commercial Lunasin was very expensive due to the high cost of lunasin synthesis and the lack of methods to obtain the pure lunasin weight from plant sources, involving time-consuming analytical instruments. To overcome these problems, the soybean extract with targeted Lunasin (ET-Lun) was made. The aim of this study was to investigate anti-cancer properties of ET-Lun in breast cancer models in vivo. Methods: Effect of ET-Lun was evaluated in 7,12-Dimetilbenz[a]antrasen (DMBA) induced breast cancer rat model. Tumor Mass, volume, and number were measured. The expression of HER2 and EGFR from each treatment group in DMBA-induced rat was evaluated using immunohistochemistry. Results: The results shown that ET-Lun could reduced tumor volume (p=0,021). ET-Lun decreased EGFR expression compared to negative control DMBA (p=0,012). Conclusions: These results indicated that the ET-Lun has anti-breast cancer activity in vivo. © 2021 Phcogj.Com. |
Breast cancer; EGFR; HER2; In-vivo; Soybean |
dimethylbenz[a]anthracene; epidermal growth factor receptor; epidermal growth factor receptor 2; lunasin; peptide; soybean extract; tamoxifen; unclassified drug; aged; animal experiment; animal model; animal tissue; antineoplastic activity; Article; breast cancer; controlled study; female; immunohistochemistry; in vivo study; nonhuman; protein expression; rat; soybean; tumor number; tumor volume |
EManuscript Technologies |
09753575 |
|
|
Article |
Q3 |
268 |
15961 |
|
|
203 |
Sasmono R.T., Johar E., Yohan B., Ma’Roef C.N., Soebandrio A., Myint K.S.A., Pronyk P., Hadinegoro S.R., Soepardi E.J., Bouckenooghe A., Hawley W., Rosenberg R., Powers A.M. |
57245712300;57204001174;55843037500;6507740388;8602893200;7003758970;6602466584;57226218772;57191174412;18233281300;7004280510;35578810900;7005770718; |
In Response: Stability of zika virus antibodies in specimens from a retrospective serological study |
2021 |
American Journal of Tropical Medicine and Hygiene |
105 |
3 |
|
853 |
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115293744&doi=10.4269%2fajtmh.21-0564b&partnerID=40&md5=4b5e07961e6006f21355f4fdf73c7fa8 |
Eijkman Institute for Molecular Biology, Jakarta, Indonesia; UNICEF Indonesia, Jakarta, Indonesia; Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Ministry of Health of the Republic of Indonesia, Jakarta, Indonesia; Sanofi Pasteur Lyon, Rhone-Alpes, France; Centers for Disease Control and Prevention, Atlanta, GA, United States; Centers for Disease Control and Prevention Fort, Collins, CO, United States |
Sasmono, R.T., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Johar, E., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Yohan, B., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Ma’Roef, C.N., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Soebandrio, A., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Myint, K.S.A., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Pronyk, P., UNICEF Indonesia, Jakarta, Indonesia; Hadinegoro, S.R., Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Soepardi, E.J., Ministry of Health of the Republic of Indonesia, Jakarta, Indonesia; Bouckenooghe, A., Sanofi Pasteur Lyon, Rhone-Alpes, France; Hawley, W., Centers for Disease Control and Prevention, Atlanta, GA, United States; Rosenberg, R., Centers for Disease Control and Prevention Fort, Collins, CO, United States; Powers, A.M., Centers for Disease Control and Prevention Fort, Collins, CO, United States |
[No abstract available] |
|
immunoglobulin G antibody; virus antibody; enzyme linked immunosorbent assay; freezing; Letter; plaque reduction neutralization test; serology; storage; Zika virus; human; retrospective study; serodiagnosis; Zika fever; Humans; Neutralization Tests; Retrospective Studies; Zika Virus; Zika Virus Infection |
American Society of Tropical Medicine and Hygiene |
00029637 |
|
34314374 |
Letter |
Q1 |
1015 |
4298 |
|
|
204 |
Heltty H., Sitorus R., Martha E., Nusdwinuringtyas N. |
57262112500;57194329674;55841280100;56608215500; |
Experience of the patient's success in facing post-stroke urinary incontinence: The patient's perspective |
2021 |
Frontiers of Nursing |
8 |
3 |
|
291 |
301 |
|
1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115061619&doi=10.2478%2ffon-2021-0030&partnerID=40&md5=9c066e6d2b1fc65cd5adc1fc8034247d |
Faculty of Nursing, Medical Surgical, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia; Faculty of Public Health, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia; Faculty of Medicine, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia |
Heltty, H., Faculty of Nursing, Medical Surgical, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia; Sitorus, R., Faculty of Nursing, Medical Surgical, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia; Martha, E., Faculty of Public Health, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia; Nusdwinuringtyas, N., Faculty of Medicine, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia |
Objective: Post-stroke urinary incontinence (UI) is one of the sequelae of stroke. This situation affects all aspects of the patient's life - physically, psychologically, socially, and spiritually. This study aimed to investigate the experience of patients' success in facing a post-stroke UI. Methods: A qualitative study using the Rapid Assessment Procedure (RAP) approach was used in this study. Informants were selected using purposive sampling. In-depth interviews with as many as 8 patients who had recovered from post-stroke UI and living in the greater area of Southeast Sulawesi (Indonesia) were conducted. In-depth interviews were also conducted with 8 caregivers and 2 nurses. Data were analyzed using a thematic analysis approach and interpretation of data was based on Humanbecoming theory and Self-care deficit theory of nursing. Results: Five successful things the patients experienced during post-stroke UI were identified. The five successes were as follows: they provided information to get to know and understand post-stroke UI, followed the procedures to overcome post-stroke UI, conducted self-control exercises and stayed motivated, performed daily activities independently according to ability, and made use of family support and peers' attention. Conclusions: These findings indicated that persistence, belief, independence, and social support (family and peer) made patients to successfully face their post-stroke UI and improved their quality of life. These findings also became the basis for developing a post-stroke UI management model based on Humanbecoming theory and Self-care deficit theory of nursing. © 2021 Heltty Heltty et al., published by Sciendo. |
experience of patient's success; patient's perspective; post-stroke urinary incontinence |
|
Sciendo |
25448994 |
|
|
Review |
Q4 |
152 |
22962 |
|
|
213 |
La Distia Nora R., Putera I., Khalisha D.F., Septiana I., Sitompul R. |
56001881000;56485949000;57219417896;57219417256;8312163900; |
The diagnostic value of polymerase chain reaction for ocular tuberculosis diagnosis in relation to antitubercular therapy response: a meta-analysis |
2021 |
International Journal of Infectious Diseases |
110 |
|
|
394 |
402 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113172042&doi=10.1016%2fj.ijid.2021.07.075&partnerID=40&md5=2517c80887d20c78446a294388261c14 |
Department of Ophthalmology, Faculty of Medicine, University of Indonesia – Cipto Mangunkusumo Kirana Eye HospitalJakarta, Indonesia; Department of Immunology, Erasmus Medical Center, Rotterdam, Netherlands; University of Indonesia Hospital (RSUI), Depok, West Java, Indonesia |
La Distia Nora, R., Department of Ophthalmology, Faculty of Medicine, University of Indonesia – Cipto Mangunkusumo Kirana Eye HospitalJakarta, Indonesia, Department of Immunology, Erasmus Medical Center, Rotterdam, Netherlands, University of Indonesia Hospital (RSUI), Depok, West Java, Indonesia; Putera, I., Department of Ophthalmology, Faculty of Medicine, University of Indonesia – Cipto Mangunkusumo Kirana Eye HospitalJakarta, Indonesia; Khalisha, D.F., Department of Ophthalmology, Faculty of Medicine, University of Indonesia – Cipto Mangunkusumo Kirana Eye HospitalJakarta, Indonesia; Septiana, I., Department of Ophthalmology, Faculty of Medicine, University of Indonesia – Cipto Mangunkusumo Kirana Eye HospitalJakarta, Indonesia; Sitompul, R., Department of Ophthalmology, Faculty of Medicine, University of Indonesia – Cipto Mangunkusumo Kirana Eye HospitalJakarta, Indonesia |
Background: Polymerase chain reaction (PCR) is currently considered the method of choice for diagnosing ocular tuberculosis. However, the sensitivity and specificity of PCR using ocular samples remain uncertain. Our meta-analysis aimed to review the diagnostic accuracy of PCR testing in confirming ocular tuberculosis, with responses to antitubercular therapy (ATT) as reference indices. Methods: A systematic literature search of the PubMed, EBSCOHost, Scopus, and Google Scholar databases was performed using the standardized PRISMA guideline. Observational studies reporting both PCR MTb positivity and ATT response were included. Meta-analysis was performed to estimate the pooled positivity rate, sensitivity, specificity, positive and negative likelihood ratios, diagnostic odds ratios (DOR), and summary receiver operating curves (SROC). Results: The pooled positivity rate for PCR MTb was 0.55 (95% CI 0.44–0.67). The overall sensitivity and specificity were 88% (95% CI 83–92) and 71% (95% CI 60–80), respectively. The pooled DOR was 12.15 (95% CI 5.55–26.62). The area under the SROC was 0.83. Conclusions: The diagnostic accuracy of PCR Mtb is not sufficient for use as a benchmark for ocular TB diagnosis routinely based on ATT response. A negative result may help avoid prescribing unnecessary ATT in dilemmatic cases. © 2021 The Author(s) |
Diagnostic accuracy; Mycobacterium tuberculosis; polymerase chain reaction; uveitis |
ethambutol; ethambutol plus isoniazid plus pyrazinamide plus rifampicin; isoniazid; isoniazid plus rifampicin; pyrazinamide; rifampicin; steroid; tuberculostatic agent; tuberculostatic agent; antibiotic therapy; Article; controlled study; diagnostic accuracy; diagnostic test accuracy study; diagnostic value; false negative result; false positive result; human; inflammation; meta analysis; nonhuman; ocular tuberculosis; polymerase chain reaction; quantitative analysis; receiver operating characteristic; recurrent disease; regression analysis; sensitivity and specificity; serpiginous choroiditis; steroid therapy; systematic review; treatment duration; treatment response; genetics; Mycobacterium tuberculosis; polymerase chain reaction; tuberculosis; Antitubercular Agents; Humans; Mycobacteriu |
Elsevier B.V. |
12019712 |
|
34364996 |
Article |
Q1 |
1278 |
2980 |
|
|
215 |
Dilogo I.H., Aditianingsih D., Sugiarto A., Burhan E., Damayanti T., Sitompul P.A., Mariana N., Antarianto R.D., Liem I.K., Kispa T., Mujadid F., Novialdi N., Luviah E., Kurniawati T., Lubis A.M.T., Rahmatika D. |
56161962800;56312263600;57189612291;36058554600;36058523500;57224505288;57194732286;57190862806;55802927800;56515348000;57204398571;57224555404;56114966200;55213290600;15122639800;57474077600; |
Umbilical cord mesenchymal stromal cells as critical COVID-19 adjuvant therapy: A randomized controlled trial |
2021 |
Stem Cells Translational Medicine |
10 |
9 |
|
1279 |
1287 |
|
8 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107732762&doi=10.1002%2fsctm.21-0046&partnerID=40&md5=197659d90f645ca5130e69fcf16b7b4d |
Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Stem Cell and Tissue Engineering Research Cluster Indonesian Medical Education and Research Institute (IMERI) Universitas Indonesia, Jakarta, Indonesia; Department of Orthopaedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Anesthesiology and Intensive Care Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Intensive Care Division, Universitas Indonesia Hospital, Depok, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Indonesia, Persahabatan General Hospital, Jakarta, Indonesia; Directorate of Medical Services, Nursing and Supporting, Sulianti Saroso Infection Disease Hospital, Jakarta, Indonesia; Directorate of Human Resources Development, Education and Operational Sulianti Saroso Infection Disease Hospital, Jakarta, Indonesia; Department of Histology, Universitas Indonesia Fakultas Kedokteran, Jakarta, Indonesia; Department of Anatomy, Universitas Indonesia Fakultas Kedokteran, Jakarta, Indonesia; Installation of Innovation Management and Intellectual Property, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Dilogo, I.H., Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Stem Cell and Tissue Engineering Research Cluster Indonesian Medical Education and Research Institute (IMERI) Universitas Indonesia, Jakarta, Indonesia, Department of Orthopaedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Aditianingsih, D., Department of Anesthesiology and Intensive Care Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Intensive Care Division, Universitas Indonesia Hospital, Depok, Indonesia; Sugiarto, A., Department of Anesthesiology and Intensive Care Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Burhan, E., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Indonesia, Persahabatan General Hospital, Jakarta, Indonesia; Damayanti, T., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Indonesia, Persahabatan General Hospital, Jakarta, Indonesia; Sitompul, P.A., Directorate of Medical Services, Nursing and Supporting, Sulianti Saroso Infection Disease Hospital, Jakarta, Indonesia; Mariana, N., Directorate of Human Resources Development, Education and Operational Sulianti Saroso Infection Disease Hospital, Jakarta, Indonesia; Antarianto, R.D., Stem Cell and Tissue Engineering Research Cluster Indonesian Medical Education and Research Institute (IMERI) Universitas Indonesia, Jakarta, Indonesia, Department of Histology, Universitas Indonesia Fakultas Kedokteran, Jakarta, Indonesia; Liem, I.K., Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Stem Cell and Tissue Engineering Research Cluster Indonesian Medical Education and Research Institute (IMERI) Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Universitas Indonesia Fakultas Kedokteran, Jakarta, Indonesia; Kispa, T., Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Mujadid, F., Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Novialdi, N., Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Luviah, E., Stem Cell and Tissue Engineering Research Cluster Indonesian Medical Education and Research Institute (IMERI) Universitas Indonesia, Jakarta, Indonesia; Kurniawati, T., Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Lubis, A.M.T., Department of Orthopaedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Installation of Innovation Management and Intellectual Property, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rahmatika, D., Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
One of the main causes of acute respiratory distress syndrome in coronavirus disease 2019 (COVID-19) is cytokine storm, although the exact cause is still unknown. Umbilical cord mesenchymal stromal cells (UC-MSCs) influence proinflammatory T-helper 2 (Th2) cells to shift to an anti-inflammatory agent. To investigate efficacy of UC-MSC administration as adjuvant therapy in critically ill patients with COVID-19, we conducted a double-blind, multicentered, randomized controlled trial at four COVID-19 referral hospitals in Jakarta, Indonesia. This study included 40 randomly allocated critically ill patients with COVID-19; 20 patients received an intravenous infusion of 1 × 106/kg body weight UC-MSCs in 100 ml saline (0.9%) solution (SS) and 20 patients received 100 ml 0.9% SS as the control group. All patients received standard therapy. The primary outcome was measured by survival rate and/or length of ventilator usage. The secondary outcome was measured by clinical and laboratory improvement, with serious adverse events. Our study showed the survival rate in the UC-MSCs group was 2.5 times higher than that in the control group (P =.047), which is 10 patients and 4 patients in the UC-MSCs and control groups, respectively. In patients with comorbidities, UC-MSC administration increased the survival rate by 4.5 times compared with controls. The length of stay in the intensive care unit and ventilator usage were not statistically significant, and no adverse events were reported. The application of infusion UC-MSCs significantly decreased interleukin 6 in the recovered patients (P =.023). Therefore, application of intravenous UC-MSCs as adjuvant treatment for critically ill patients with COVID-19 increases the survival rate by modulating the immune system toward an anti-inflammatory state. © 2021 The Authors. STEM CELLS TRANSLATIONAL MEDICINE published by Wiley Periodicals LLC on behalf of AlphaMed Press. |
adjuvants; cord stem cell transplantation; COVID-19; cytokine release syndrome; immunology; mesenchymal stromal cells |
5' nucleotidase; azithromycin; C reactive protein; CD34 antigen; CD4 antigen; CD56 antigen; CD8 antigen; chemokine receptor CXCR3; D dimer; ferritin; fibrinogen; hemoglobin; interleukin 10; interleukin 6; lactic acid; leukemia inhibitory factor; oseltamivir; procalcitonin; Thy 1 membrane glycoprotein; vasculotropin; adjuvant therapy; adult; adult respiratory distress syndrome; Article; artificial ventilation; blood cell count; clinical article; clinical decision making; computer assisted tomography; controlled study; coronavirus disease 2019; critically ill patient; cytokine release syndrome; cytokine storm; double blind procedure; female; flow cytometry; fluid resuscitation; ground glass opacity; hematocrit; Horowitz index; human; hypotension; intensive care unit; length of stay; leukopen |
John Wiley and Sons Ltd |
21576564 |
|
34102020 |
Article |
Q1 |
1781 |
1654 |
|
|
216 |
Pawankar R., Thong B.Y.-H., Tiongco-Recto M., Wang J.-Y., Abdul Latiff A.H., Thien F., Oh J.-W., Kamchaisatian W., Rengganis I., Udwadia Z.F., Dhar R., Munkhbayarlakh S., Narantsetseg L., Le Pham D., Leung T.F., Zhang L., APAAACI COVID-19 Working Group |
7005904460;6603816215;55359899500;56499349900;55608026700;57204250177;55657464600;6505855073;8449988000;57192641184;7006700626;56800881300;8977752900;57201431490;57225672394;36068675900; |
Asia-Pacific perspectives on the COVID-19 pandemic |
2021 |
Allergy: European Journal of Allergy and Clinical Immunology |
76 |
9 |
|
2998 |
2901 |
|
2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106213191&doi=10.1111%2fall.14894&partnerID=40&md5=a8dda5140c82a54f09e8a12b2804a47c |
Division of Allergy, Department of Pediatrics, Nippon Medical School, Tokyo, Japan; Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore City, Singapore; Division of Allergy and Immunology, Department of Pediatrics, University of the Philippines-Philippine General Hospital, Manila, Philippines; Centre of Allergy and Clinical Immunology Research (ACIR), Department of Paediatrics, National Cheng Kung University Hospital, Tainan, Taiwan; Allergy & Immunology Centre Pantai Hospital, Kuala Lumpur, Malaysia; Department of Paediatrics, Universiti Putra Malaysia Teaching Hospital, Kuala Lumpur, Malaysia; Eastern Health, Monash University, Melbourne, Vic, Australia; Department of Pediatrics, Hanyang University Guri Hospital, Guri, Gyunggi-Do, South Korea; Pediatric Allergy and Immunology Division, Samitivej Children’s Hospital, Bangkok, Thailand; Division of Allergy and Clinical Immunology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, CiptoMangunkusumo General Hopsital, Jakarta, Indonesia; P.D. Hinduja National Hospital and Medical Research Centre and the Breach Candy Hospital, Mumbai, India; Department of Pulmonology, C K BIRLA Group of Hospitals, CMRIKolkata, India; Department of Pulmonology and Allergology, School of Medicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia; Department of Biochemistry, School of Biomedicine, MongolianNational University of Medical Sciences, Ulaanbaatar, Mongolia; Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam; Department of Pediatrics, Chinese University of Hong Kong, Hong Kong; Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China |
Pawankar, R., Division of Allergy, Department of Pediatrics, Nippon Medical School, Tokyo, Japan; Thong, B.Y.-H., Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore City, Singapore; Tiongco-Recto, M., Division of Allergy and Immunology, Department of Pediatrics, University of the Philippines-Philippine General Hospital, Manila, Philippines; Wang, J.-Y., Centre of Allergy and Clinical Immunology Research (ACIR), Department of Paediatrics, National Cheng Kung University Hospital, Tainan, Taiwan; Abdul Latiff, A.H., Allergy & Immunology Centre Pantai Hospital, Kuala Lumpur, Malaysia, Department of Paediatrics, Universiti Putra Malaysia Teaching Hospital, Kuala Lumpur, Malaysia; Thien, F., Eastern Health, Monash University, Melbourne, Vic, Australia; Oh, J.-W., Department of Pediatrics, Hanyang University Guri Hospital, Guri, Gyunggi-Do, South Korea; Kamchaisatian, W., Pediatric Allergy and Immunology Division, Samitivej Children’s Hospital, Bangkok, Thailand; Rengganis, I., Division of Allergy and Clinical Immunology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, CiptoMangunkusumo General Hopsital, Jakarta, Indonesia; Udwadia, Z.F., P.D. Hinduja National Hospital and Medical Research Centre and the Breach Candy Hospital, Mumbai, India; Dhar, R., Department of Pulmonology, C K BIRLA Group of Hospitals, CMRIKolkata, India; Munkhbayarlakh, S., Department of Pulmonology and Allergology, School of Medicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia; Narantsetseg, L., Department of Biochemistry, School of Biomedicine, MongolianNational University of Medical Sciences, Ulaanbaatar, Mongolia; Le Pham, D., Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam; Leung, T.F., Department of Pediatrics, Chinese University of Hong Kong, Hong Kong; Zhang, L., Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China; APAAACI COVID-19 Working Group |
[No abstract available] |
|
biological product; chloroquine; convalescent plasma; corticosteroid; hydroxychloroquine; immunosuppressive agent; lopinavir plus ritonavir; remdesivir; tocilizumab; asthma; chronic rhinosinusitis; coronavirus disease 2019; desensitization; device infection; eye allergy; health care access; health care policy; health care survey; human; immunosuppressive treatment; infection control; infection prevention; latex allergy; Letter; medical device complication; mutation; pandemic; phenotype; protective glasses; questionnaire; Asia; epidemiology; pandemic; Asia; COVID-19; Humans; Pandemics; SARS-CoV-2 |
John Wiley and Sons Inc |
01054538 |
|
33948966 |
Letter |
Q1 |
3363 |
542 |
|
|