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24 |
Wardatun S., Harahap Y., Sutandyo N., Mun'im A. |
56656540800;16480400300;26028099200;57200562136; |
Analyzing of Urine 3-Hidroxy Propil Mercapturic Acid on Cyclophosphamide Induced Rat to Determine Ameliorating Effect of Leucaena leucocephala (Lam.) de Wit Seed Extract |
2021 |
Pharmacognosy Journal |
13 |
6 |
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1549 |
1556 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122983266&doi=10.5530%2fpj.2021.13.197&partnerID=40&md5=800384ddb85b8305ebff1ba328165147 |
Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Program Study of Pharmacy, Universitas Pakuan, Bogor, Indonesia; Faculty of Pharmacy, Republic of Indonesia Defense University, Bogor, Indonesia; Dharmais, Cancer Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Depok, Indonesia |
Wardatun, S., Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia, Program Study of Pharmacy, Universitas Pakuan, Bogor, Indonesia; Harahap, Y., Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia, Faculty of Pharmacy, Republic of Indonesia Defense University, Bogor, Indonesia; Sutandyo, N., Dharmais, Cancer Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Mun'im, A., Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia |
Background: A 70% ethanolic extract of Leucaena leucocephala (Lam.) de Wit seeds contain a certain amount of sulfhydryl active compounds and potential for ameliorated cyclophosphamide side effects. Objective: The aim of this study was to analyze of urine 3-hidroxy propil mercapturic acid (3-HPMA) in a rat model for cyclophosphamide-induced hemorrhagic cystitis to determine the effect of Leucaena leucocephala (Lam.) de Wit seeds extract. Materials and methods: The levels of urine 3-hidroxy propil mercapturic acid was measured using LCMS/MS. Urine preparation was carried out by dilution (1:5) with mobile phase and contained a deuteurated internal standard. The LC separation was performed using a C18 column (1.7 μm; 2.1 mm × 100 mm). The mobile phase consisted of formic acid (0.1%) and formic acid (0.1%) in acetonitrile (90:10 v/v), as a starting gradient at flow rate of 0.2 ml/min with total run 7 min. Results: The lower limit of quantification was 40 ng/ml and the linear extended to 20,000 ng/ml. The method has been successfully to be applied in determined of rat urine 3-HPMA. The results showed that the 70% ethanolic extract of seeds can increased the amount of 3-HPMA in rat urine. Conclusion: The 70% ethanolic extract of seeds displayed a potential ameliorating effect against cyclophosphamide side effects. © 2021 Phcogj.Com. |
3-Hidroxypropil mercapturic acid; Cyclophosphamide; Leucaena leucocephala (Lam.) de Wit; Urine |
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EManuscript Technologies |
09753575 |
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Article |
Q3 |
268 |
15961 |
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25 |
Teja Y., Helianthi D.R., Nareswari I. |
57325017200;57194729482;57194336586; |
The Role of Medical Acupuncture Therapy in Alzheimer's Disease |
2021 |
Medical Acupuncture |
33 |
6 |
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396 |
402 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122562853&doi=10.1089%2facu.2021.0014&partnerID=40&md5=a4d04ed95475b2b444ea8f76846422fb |
Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Indonesia; Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Teja, Y., Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Indonesia, Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Helianthi, D.R., Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Indonesia, Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Nareswari, I., Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Indonesia, Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Objective: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory deficits and other cognitive disorders, which can be accompanied by personality changes. Long-term use of medications available to treat AD today have a variety of side-effects. Acupuncture, as a nonpharmacologic therapeutic modality providing stimulation at acupuncture points, using filiform needles, has been widely tested and used to manage of AD and can be a therapeutic option, considering its effectiveness and lack of side-effects. Methods: This literature review examines the role of acupuncture in AD treatment. Results: Acupuncture can ameliorate AD symptoms through decreasing amyloid-β protein, reducing neuroinflammation, enhancing the antioxidant system, improving neurogenesis, enhancing prosurvival protein, reducing proapoptotic protein, and regulating brain energy metabolism. Conclusions: According to various research findings, acupuncture may be a therapeutic choice for addressing AD that avoids the long-term side-effects caused by medical therapy. © 2021, Mary Ann Liebert, Inc., publishers. |
Acupuncture; Alzheimer's disease; Amyloid-β (Aβ) plaques; Neurofibrillary tangles; τ-protein |
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Mary Ann Liebert Inc. |
19336586 |
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Article |
Q2 |
281 |
15498 |
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26 |
Soemantri D., Greviana N., Findyartini A., Azzahra T.B., Suryoadji K.A., Mustika R., Felaza E. |
36640659100;57197709749;56543777300;57223601523;57223633894;57220273147;57217487889; |
"To obey or not to obey" - Medical students' response towards professional dilemmas in a hierarchical and collectivist culture |
2021 |
PLoS ONE |
16 |
12 December |
e0261828 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122028276&doi=10.1371%2fjournal.pone.0261828&partnerID=40&md5=379871263550acde1f1182540ba60243 |
Faculty of Medicine, Department of Medical Education, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Undergraduate Medical Program, Universitas Indonesia, Jakarta, Indonesia |
Soemantri, D., Faculty of Medicine, Department of Medical Education, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Greviana, N., Faculty of Medicine, Department of Medical Education, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Findyartini, A., Faculty of Medicine, Department of Medical Education, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Azzahra, T.B., Faculty of Medicine, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Undergraduate Medical Program, Universitas Indonesia, Jakarta, Indonesia; Suryoadji, K.A., Faculty of Medicine, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Undergraduate Medical Program, Universitas Indonesia, Jakarta, Indonesia; Mustika, R., Faculty of Medicine, Department of Medical Education, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Felaza, E., Faculty of Medicine, Department of Medical Education, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia |
Background Clinical clerkship programme in medical schools were developed to provide students with direct interactions with patients and observe clinical teachers in practice. However, professional dilemmas are prone to occur due to the nature of experiential learning. Several studies across different cultures showed that medical students responded differently towards professional dilemma. Aims This study aims to explore how medical students respond to professional dilemmas occurred during their clinical clerkships and to what extent culture influences the responses. Method A qualitative descriptive approach was used in this study. We conducted four focus group discussions with final year medical students who were selected using maximum variety sampling method. Thematic analysis was conducted following the transcription of the focus groups. Results We identified the impact of dilemmas on students' emotions and concerns, students' responses towards professional dilemmas, and factors affecting responses to dilemmas in clinical clerkship, which confirmed that cultures played roles in how students responded towards professional dilemmas. Conclusion This study has identified that culture, to some extent, influenced the way students responded to professional dilemmas. Therefore, it is paramount to develop a conducive and culturally sensitive educational environment and students' ability to learn from professional dilemma experienced in the workplace for developing their professional identity. © 2021 Soemantri et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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article; clinical education; emotion; genetic transcription; human; human experiment; medical student; thematic analysis; workplace; clinical trial; emotion; female; male; medical school; problem based learning; Emotions; Female; Humans; Male; Problem-Based Learning; Schools, Medical; Students, Medical |
Public Library of Science |
19326203 |
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34941959 |
Article |
Q1 |
990 |
4434 |
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27 |
Koesnoe S., Masjkuri N., Adisasmita A., Djauzi S., Kartasasmita C., Sundoro J., Nadjib M., Korib M., Muthia A.N., Muzellina V.N., Habibah U., Nursyirwan S.A., Djaya K.H., Bachtiar N.S., Sari R.M. |
26028015000;57189271669;22978283200;23495847800;57206248946;49762130000;24401623600;57391576000;57391576100;57223968527;57391443900;57249143800;57392218600;54879388400;57191341371; |
A randomized controlled trial to evaluate the effect of influenza vaccination and probiotic supplementation on immune response and incidence of influenza-like illness in an elderly population in Indonesia |
2021 |
PLoS ONE |
16 |
12 December |
e0250234 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122024701&doi=10.1371%2fjournal.pone.0250234&partnerID=40&md5=6918933f17507c8ed64013b241adb3c2 |
Division of Allergy and Immunology, Department of Internal Medicine, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Division of Allergy and Immunology, Department of Internal Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Department of Epidemiology, Faculty of Public Health University of Indonesia Jakarta, Jakarta, Indonesia; Department of Child Health, Faculty of Medicine, Padjadjaran University, Hasan Sadikin General Hospital, Bandung, Indonesia; Indonesian Technical Advisory Group on Immunization, Jakarta, Indonesia; Department of Health Policy and Administration, Faculty of Public Health University of Indonesia, Jakarta, Indonesia; Indonesian Society of Internal Medicine, Jakarta, Indonesia; Division of Gastroenterology, Depertment of Internal Medicine, dr. Cipto Mangunkusomo Hospital, Jakarta, Indonesia; Division of Gastroenterology, Depertment of Internal Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; PT. Bio Farma, Bandung, Indonesia |
Koesnoe, S., Division of Allergy and Immunology, Department of Internal Medicine, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Division of Allergy and Immunology, Department of Internal Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Masjkuri, N., Department of Epidemiology, Faculty of Public Health University of Indonesia Jakarta, Jakarta, Indonesia; Adisasmita, A., Department of Epidemiology, Faculty of Public Health University of Indonesia Jakarta, Jakarta, Indonesia; Djauzi, S., Division of Allergy and Immunology, Department of Internal Medicine, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Division of Allergy and Immunology, Department of Internal Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Kartasasmita, C., Department of Child Health, Faculty of Medicine, Padjadjaran University, Hasan Sadikin General Hospital, Bandung, Indonesia; Sundoro, J., Indonesian Technical Advisory Group on Immunization, Jakarta, Indonesia; Nadjib, M., Department of Health Policy and Administration, Faculty of Public Health University of Indonesia, Jakarta, Indonesia; Korib, M., Department of Epidemiology, Faculty of Public Health University of Indonesia Jakarta, Jakarta, Indonesia; Muthia, A.N., Indonesian Society of Internal Medicine, Jakarta, Indonesia; Muzellina, V.N., Division of Gastroenterology, Depertment of Internal Medicine, dr. Cipto Mangunkusomo Hospital, Jakarta, Indonesia, Division of Gastroenterology, Depertment of Internal Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Habibah, U., Indonesian Society of Internal Medicine, Jakarta, Indonesia; Nursyirwan, S.A., Division of Gastroenterology, Depertment of Internal Medicine, dr. Cipto Mangunkusomo Hospital, Jakarta, Indonesia, Division of Gastroenterology, Depertment of Internal Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Djaya, K.H., Indonesian Society of Internal Medicine, Jakarta, Indonesia; Bachtiar, N.S., PT. Bio Farma, Bandung, Indonesia; Sari, R.M., PT. Bio Farma, Bandung, Indonesia |
Aim To investigate the effect of influenza vaccination with or without probiotic supplementation on the immune response and incidence of influenza-like illness (ILI) in the elderly. Methods A randomized double-blind, placebo-controlled trial with a modified factorial design was conducted in 554 healthy elderly subjects aged 67 ± 5.6 (ranging from 60–90) years old in the Primary Health Care Center (Puskesmas area) of the Pulo Gadung District East Jakarta. Subjects received either a trivalent influenza vaccine or placebo at the start of the study, and a probiotic supplement (Lactobacillus helveticus R0052 and Lactobacillus rhamnosus R0011) or a placebo for 6 months. Subjects were randomly assigned into four intervention groups: influenza vaccine and probiotics (n = 141), influenza vaccine and placebo (n = 136), placebo and probiotics (n = 140), and both placebo (n = 137). The primary outcome was ILI incidence within 6 months. The secondary outcomes were seroprotection and seroconversion rates at 1, 4, and 6 months after administering the interventions. Results This study showed that the trivalent influenza vaccine increased seroprotection (RR 3.6 [95%CI 2.92–4.47]; p<0.010) and seroconversion (RR 29.8 [95%CI 11.1–79.5]; p<0.010) rates 1 month after vaccination in elderly people while the probiotic supplement did not alter influenza antibody titers (p = 1.000 and p = 0.210). The relative ILI incidence risk was similar between vaccinated and non-vaccinated groups, as well as in the probiotic group compared to the non-probiotic group. Conclusion The tested trivalent influenza vaccine significantly induced seroprotection and seroconversion in the vaccinated subjects, while probiotics administration did not influence these parameters. Vaccinated individuals displayed a similarly low ILI incidence as those in the Control Group. However, the observed trend towards a reduction of ILI incidence with probiotics supplementation warrants further assessments in a larger, at-risk population. © 2021 Koesnoe et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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flubio; influenza vaccine; placebo; influenza vaccine; probiotic agent; adult; aged; antibody titer; Article; controlled study; diet supplementation; double blind procedure; drug effect; female; human; immune response; incidence; Indonesia; influenza; major clinical study; male; middle aged; population risk; population structure; primary health care; randomized controlled trial; sample size; seroconversion; treatment duration; treatment outcome; vaccination; very elderly; incidence; influenza; Lactobacillus helveticus; Lactobacillus rhamnosus; Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Incidence; Indonesia; Influenza Vaccines; Influenza, Human; Lactobacillus helveticus; Lactobacillus rhamnosus; Male; Middle Aged; Probiotics |
Public Library of Science |
19326203 |
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34914726 |
Article |
Q1 |
990 |
4434 |
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28 |
Lubis A.M., Maruanaya S., Tantri A.R., Pontoh L.A.P., Ifran N.N.P.P.S. |
57391310600;57217187200;57188933853;57192907426;56091403800; |
The Use of Combination Paracetamol and Ibuprofen in Postoperative Pain after Total Knee Arthroplasty, a Randomized Controlled Trial |
2021 |
Pain physician |
24 |
8 |
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E1199 |
E1204 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121993999&partnerID=40&md5=0b79df4a67066c8ba9a1818d9c6e9920 |
Department of Orthopedic & Traumatology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, DKI Jakarta, Indonesia; Universitas PattimuraMaluku, Indonesia; Department of Anesthesiology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, DKI Jakarta, Indonesia; Department of Orthopedic, Fatmawati General Hospital, DKI Jakarta, Indonesia; Department of Orthopedic & Traumatology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, DKI Jakarta, Indonesia |
Lubis, A.M., Department of Orthopedic & Traumatology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, DKI Jakarta, Indonesia; Maruanaya, S., Universitas PattimuraMaluku, Indonesia; Tantri, A.R., Department of Anesthesiology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, DKI Jakarta, Indonesia; Pontoh, L.A.P., Department of Orthopedic, Fatmawati General Hospital, DKI Jakarta, Indonesia; Ifran, N.N.P.P.S., Department of Orthopedic & Traumatology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, DKI Jakarta, Indonesia |
BACKGROUND: Adequate pain management has an important role in supporting early ambulation after total knee arthroplasty (TKA). Multimodal analgesia is one of the modalities of overcoming postoperative pain. The use of a combination of paracetamol and ibuprofen is expected to reduce the total morphine requirement after TKA. OBJECTIVES: The use of a combination of paracetamol and ibuprofen to reduce morphine requirement after TKA, to provide adequate pain management and early ambulation. STUDY DESIGN: Patients scheduled for total knee arthroplasty who met the requirements for inclusion criteria were consented and randomized using randomizer.org in a 1:1:1 ratio to receive either combination paracetamol iv and ibuprofen iv (Group II), paracetamol iv only (Group II), or ibuprofen iv only (III). SETTING: Thirty-six patients aged 63-68 years who underwent TKA were included in this study. METHODS: All patients were divided into 3 groups. Group I received paracetamol 1 g and ibuprofen 800 mg, group II received 1 g paracetamol iv and 100 mL normal saline, group III received 800 mg ibuprofen iv and 100 mL normal saline, 10 minutes before the end of surgery and every 6 hours up to 24 hours. Total morphine consumption, pain score (resting, walking, knee flexion), and 2 minute-length walking tests were measured in hour 24 postoperative. Data were analyzed with SPSS 16.0. RESULTS: Median of total morphine consumption between 3 groups respectively was 7.5 (3.0-36.0) mg vs 15.0 (4.5-28.5) mg vs 9.0 (0.0-24.0) mg with no difference (P = 0.391). Mean of pain score at walking phase respectively was 4.8 ± 0.5 vs 7.3 ± 1.2 vs 5.6 ± 0.5 (hour 24, P < 0.01). Medians of 2-Minute Walking Test respectively were 6.0 (2-16) meters vs 0.0 (0-4) meters vs 0.0 (0-4) meters (hour 24, P < 0.01). LIMITATIONS: The total morphine requirement measured in this study illustrates the consumption of morphine in resting phase. CONCLUSION: The combination of paracetamol and ibuprofen is better in reducing the total morphine requirement after TKA when compared with the administration of paracetamol injection alone or ibuprofen injection alone. Combination paracetamol injection and ibuprofen injection also provides adequate pain management in order to help early ambulation. |
ibuprofen; morphine consumption; pain score; paracetamol; TKA; Multimodal analgesia |
ibuprofen; morphine; narcotic analgesic agent; paracetamol; controlled study; double blind procedure; human; knee replacement; postoperative pain; randomized controlled trial; Acetaminophen; Analgesics, Opioid; Arthroplasty, Replacement, Knee; Double-Blind Method; Humans; Ibuprofen; Morphine; Pain, Postoperative |
NLM (Medline) |
21501149 |
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34793640 |
Article |
Q1 |
1310 |
2852 |
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29 |
Ariwicaksono S.T.C., Rahardjo H.E. |
57212582959;37762030000; |
The comparison of intravesical hyaluronic acid and other modalities for the improvement of interstitial cystitis symptoms: A systematic reviews and meta-analysis |
2021 |
Bali Medical Journal |
10 |
3 |
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970 |
974 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121978362&doi=10.15562%2fbmj.v10i3.2510&partnerID=40&md5=0ddadc212b9221f4fe1b9ed43099c7b2 |
Department of Urology, Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia |
Ariwicaksono, S.T.C., Department of Urology, Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Rahardjo, H.E., Department of Urology, Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia |
Background: Interstitial cystitis (IC) is a chronic inflammation of the bladder which causes unpleasant sensations. This condition considerably reduces patients’ quality of life. Intravesical hyaluronic acid is one of the new interventions for interstitial cystitis management, in which a thorough review and meta-analysis regarding this topic are still limited. This study aimed to compare the efficacy of intravesical hyaluronic acid with other intravesical treatment modalities available to treat interstitial cystitis. Method: Systematic literature searching with the main keywords of “interstitial cystitis” or “bladder pain syndrome” and “intravesical hyaluronic acid” was conducted. The main outcome of this study was pain assessment using a visual analogue scale (VAS) and Interstitial Cystitis Symptoms Index (ICSI), and problem index (ICPI). Meta-analysis was carried out when comparative studies were available. Eleven studies were obtained to assess intravesical hyaluronic acid’s effects, including three in the meta-analysis. The intravesical treatments found as a comparison were heparin and chondroitin sulphate. Result: There was significant heterogeneity among studies included in all parameters. The pooled analysis showed no significant difference in VAS reduction, improvement of ICSI and ICPI score (p = 0.11, p = 0.35, and p = 0.28, respectively) between hyaluronic acid and other intravesical treatments. Conclusion: There was no significant difference between hyaluronic acid and other intravesical treatments. However, further research with a larger sample is needed to confirm the best modalities in interstitial cystitis. © 2021, Sanglah General Hospital. All rights reserved. |
Hyaluronic acid; ICPI; ICSI; Interstitial cystitis; Pain; Symptoms; VAS |
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Sanglah General Hospital |
20891180 |
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Article |
#N/A |
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Alinda M.D., Christopher P.M., Listiawan M.Y., Endaryanto A., Suroto H., Rantam F.A., Hendradi E., Notobroto H.B., Menaldi S.L.S.W., Prakoeswa C.R.S. |
57202009260;57222755186;57202006621;55043187100;57148243900;6506692524;6507663471;56444366000;57192918198;57189894608; |
Comparative efficacy of topical adipocyte-derived mesenchymal stem cells-conditioned medium (Admsc-cm) and amniotic membrane mesenchymal stem cells-conditioned medium (amsc-cm) on chronic plantar ulcers in leprosy: A randomized controlled trial |
2021 |
Bali Medical Journal |
10 |
3 |
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958 |
963 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121976659&doi=10.15562%2fbmj.v10i3.2747&partnerID=40&md5=2cb312268e5b8b08565af75e187acace |
Post Graduate Doctoral Program, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, East Java, Surabaya, Indonesia; Leprosy Study Group, Institute of Tropical Diseases, Universitas Airlangga, Surabaya, Indonesia; Universitas Airlangga Teaching Hospital, Surabaya, Indonesia; Faculty of Medicine, Universitas Pelita Harapan, Banten, Tangerang, Indonesia; Department of Pediatric, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, East Java, Surabaya, Indonesia; Cell and Tissue Bank, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, East Java, Surabaya, Indonesia; Department of Orthopaedic & Traumatology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, East Java, Surabaya, Indonesia; Stem Cell Research and Development Center, Universitas Airlangga, East Java, Surabaya, Indonesia; Faculty of Pharmacy, Universitas Airlangga, East Java, Surabaya, Indonesia; Faculty of Public Health, Universitas Airlangga, East Java, Surabaya, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central Public Hospital, Jakarta, Indonesia |
Alinda, M.D., Post Graduate Doctoral Program, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, Indonesia, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, East Java, Surabaya, Indonesia, Leprosy Study Group, Institute of Tropical Diseases, Universitas Airlangga, Surabaya, Indonesia, Universitas Airlangga Teaching Hospital, Surabaya, Indonesia; Christopher, P.M., Faculty of Medicine, Universitas Pelita Harapan, Banten, Tangerang, Indonesia; Listiawan, M.Y., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, East Java, Surabaya, Indonesia, Leprosy Study Group, Institute of Tropical Diseases, Universitas Airlangga, Surabaya, Indonesia; Endaryanto, A., Department of Pediatric, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, East Java, Surabaya, Indonesia; Suroto, H., Cell and Tissue Bank, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, East Java, Surabaya, Indonesia, Department of Orthopaedic & Traumatology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, East Java, Surabaya, Indonesia; Rantam, F.A., Stem Cell Research and Development Center, Universitas Airlangga, East Java, Surabaya, Indonesia; Hendradi, E., Faculty of Pharmacy, Universitas Airlangga, East Java, Surabaya, Indonesia; Notobroto, H.B., Faculty of Public Health, Universitas Airlangga, East Java, Surabaya, Indonesia; Menaldi, S.L.S.W., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central Public Hospital, Jakarta, Indonesia; Prakoeswa, C.R.S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, East Java, Surabaya, Indonesia, Leprosy Study Group, Institute of Tropical Diseases, Universitas Airlangga, Surabaya, Indonesia |
Introduction: Chronic Plantar Ulcer of Leprosy (CPUL), one of the debilitating disabilities and complications, poses a treatment challenge. Utilization of stem cells, specifically adipocyte-derived mesenchymal stem cells-conditioned medium (ADMSC-CM) and amniotic membrane mesenchymal stem cells-conditioned medium (AMSC-CM), may serve as a novel therapeutic option. This study aims to compare the efficacy of topical ADMSC-CM, topical AMSC-CM, and farmazertin gauze dressing (FGD) only on the healing of CPUL. Methods: In this randomized controlled trial, our study recruited 54 subjects with CPUL. Subjects were randomly assigned to topical ADMSC-CM (n = 16), topical AMSC-CM (n = 22), or FGD (n = 16) applied every three days for up to 8 weeks. Data were analyzed using SPSS version 20 for Windows. Results: Healing percentage increased each week in all groups. Statistic differences between groups (p <0.05) were observed for ulcer mean size and depth reduction from week three onwards. No adverse reactions or complications were reported. At the end of the study, based on clinically improved ulcers, topical ADMSC-CM (100.0%) were superior in improving the healing of CPULs compared to topical AMSC-CM (54.55%) and FGD only (50.0%). Conclusion: ADMSC-CM and AMSC-CM are potential therapeutic agents in the management of CPUL, with ADMSC-CM being superior in overall ulcer improvement. © 2021, Sanglah General Hospital. All rights reserved. |
ADMSC-CM; AMSC-CM; CPUL; Leprosy; Tropical Disease |
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Sanglah General Hospital |
20891180 |
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Article |
#N/A |
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31 |
Nusanti S., Dearaini, Bani A.P., Kartasasmita A.S., Ichsan A.M., Virgana R., Anggraini N., Rahayu T., Irfani I., Edwar L., Rifada M., Yudantha A.R., Ismail M.A., Komaratih E., Wildan A., Knoch A.M.H. |
57189727162;57386841000;53663268800;37002851300;57218514954;56922099400;57387397200;57208305374;57201131541;55695047800;55249679300;55489644900;57386650700;57204192624;57205025156;57386841100; |
Delivering a modified continuous objective structured clinical examination for ophthalmology residents through a hybrid online method |
2021 |
Korean Journal of Medical Education |
33 |
4 |
|
419 |
430 |
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|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121800362&doi=10.3946%2fkjme.2021.210&partnerID=40&md5=f12d396df59aa176538ef352c359c609 |
Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Ophthalmology, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia; Department of Ophthalmology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Department of Ophthalmology, Faculty of Medicine, Airlangga University, Surabaya, Indonesia; Department of Ophthalmology, Faculty of Medicine, Diponegoro University, Semarang, Indonesia |
Nusanti, S., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Dearaini, Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Bani, A.P., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kartasasmita, A.S., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia; Ichsan, A.M., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Virgana, R., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia; Anggraini, N., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahayu, T., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Irfani, I., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia; Edwar, L., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rifada, M., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yudantha, A.R., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ismail, M.A., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Komaratih, E., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Airlangga University, Surabaya, Indonesia; Wildan, A., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Knoch, A.M.H., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia |
Since coronavirus disease 2019 was declared a global pandemic by the World Health Organization, it has become a challenging situation to continue medical education, including in Indonesia. The situation prohibited face-to-face (direct) educational activities in clinical settings, therefore also postponing examinations involving especially procedural skills. Adaptations were urgently needed to maintain the delivery of high-stake examinations to sustain the number of ophthalmology graduates and the continuation of eye health service. Objective structured clinical examination (OSCE) has been one of our widely used method to assess clinical competencies for ophthalmology residents, and is the one method that involves gatherings, close contact of examiners, examinees and patients, therefore the most difficult to adjust. Pandemic challenges brought technical changes in our delivering the OSCE to online, maximizing digital platforms of meetings, while still concerned to guarding the safety of candidates, patients and staffs. OSCE scenarios were also made as timely efficient as possible by changing continuous station models to a cascade one. The purpose of this article is to document our experience in conducting a feasible and reproducible OSCE in this pandemic era filled with limitations. © The Korean Society of Medical Education. All rights reserved. |
COVID-19; Education; Internship and residency; Methods; Ophthalmology / education |
clinical competence; education; health service; human; medical education; ophthalmology; Clinical Competence; COVID-19; Educational Measurement; Health Services; Humans; Internship and Residency; Ophthalmology; SARS-CoV-2 |
Korean Society of Medical Education |
2005727X |
|
34875158 |
Article |
Q4 |
175 |
21057 |
|
|
|
32 |
Yo E.C., Witjaksono A.N., Fitriani D.Y., Werdhani R.A., Parikesit D. |
57213188908;57224351398;57224589606;57189088848;57163830300; |
Evaluating knowledge retention and perceived benefits of medical webinar for professional development among Indonesian physicians |
2021 |
Korean Journal of Medical Education |
33 |
4 |
|
381 |
391 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121761218&doi=10.3946%2fkjme.2021.206&partnerID=40&md5=88879a0b2b85137bc0337e9c3aa3de9b |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ophthalmology Medical Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, Depok, Indonesia; Occupational Medicine Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, Depok, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Urology Medical Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, Depok, Indonesia |
Yo, E.C., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Witjaksono, A.N., Ophthalmology Medical Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, Depok, Indonesia; Fitriani, D.Y., Occupational Medicine Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, Depok, Indonesia, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Werdhani, R.A., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Parikesit, D., Urology Medical Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, Depok, Indonesia |
Purpose: To assess knowledge retention of physicians after participating in a webinar series and its perceived benefits on daily practice and career development. Methods: The webinar series comprised six separate webinars about daily practice. Online questionnaires were sent to all participating physicians via email 3 months after the webinars. The questionnaire assessed knowledge retention through the difference between initial and follow-up post-test as well as the webinar series' benefits on daily practice and career development. Participants' demographic information, including their age, gender, education, year of graduation, and work details, were collected to compare outcomes between demographic groups. Results: A total of 689 responses were gathered, and 622 were analyzed. At follow-up, the median knowledge score was significantly lower than the initial median knowledge score (Z=-6.973, p<0.001). Participants' perception of the webinar series' benefits on daily practice and career development was very positive. A significant weak negative correlation was found between age and knowledge score at follow-up (rs=-0.157, p<0.001). Physicians who graduated more recently and worked for less than 3 years scored significantly higher on knowledge tests at follow-up. Meanwhile, perception score towards webinar series' benefits on daily practice was significantly higher among physicians with more extended work history. Male physicians scored significantly higher on perception score towards webinar series' benefits on career development. Conclusion: Online continuing medical education programs like webinars can encourage physicians to maintain their competence, but further research on improving knowledge retention over time is necessary. Overall, physicians perceived webinars to be beneficial for their professional development. © The Korean Society of Medical Education. All rights reserved. |
Continuing medical education; Knowledge retention; Physicians; Professional development; Videoconference |
human; Indonesia; male; medical education; physician; questionnaire; Education, Medical, Continuing; Humans; Indonesia; Male; Physicians; Surveys and Questionnaires |
Korean Society of Medical Education |
2005727X |
|
34875154 |
Article |
Q4 |
175 |
21057 |
|
|
|
33 |
Umbarawan Y., Kawakami R., Syamsunarno M.R.A.A., Obinata H., Yamaguchi A., Hanaoka H., Hishiki T., Hayakawa N., Koitabashi N., Sunaga H., Matsui H., Kurabayashi M., Iso T. |
57196077830;57210447153;36142388300;6506181723;23394341400;56020036100;7004072867;57221461061;6603109711;55061468300;57212330485;7103371684;7003498756; |
Reduced fatty acid use from cd36 deficiency deteriorates streptozotocin-induced diabetic cardiomyopathy in mice |
2021 |
Metabolites |
11 |
12 |
881 |
|
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121605641&doi=10.3390%2fmetabo11120881&partnerID=40&md5=50b9a38996d07912da5741dbe717f2f0 |
Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya no. 6, Jakarta, 10430, Indonesia; Department of Biomedical Sciences, Universitas Padjadjaran, Jl. Raya Bandung Sumedang KM 21, Jatinangor, 45363, Indonesia; Education and Research Support Center, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Department of Bioimaging Information Analysis, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Department of Biochemistry, Keio University School of Medicine, 35 Shinano-Machi, Shinjuku-Ku, Tokyo, 160-8582, Japan; Clinical and Translational Research Center, Keio University School of Medicine, 35 Shinano-Machi, Shinjuku-Ku, Tokyo, 160-8582, Japan; Center for Liberal Arts and Sciences, Ashikaga University, 268-1 Omae-Machi, Ashikaga, 326-8558, Japan; Department of Laboratory Sciences, Gunma University Graduate School of Health Sciences, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Department of Medical Technology and Clinical Engineering, Gunma University of Health and Welfare, 191-1 Kawamagari-Machi, Maebashi, 371-0823, Japan |
Umbarawan, Y., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya no. 6, Jakarta, 10430, Indonesia; Kawakami, R., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Syamsunarno, M.R.A.A., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan, Department of Biomedical Sciences, Universitas Padjadjaran, Jl. Raya Bandung Sumedang KM 21, Jatinangor, 45363, Indonesia; Obinata, H., Education and Research Support Center, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Yamaguchi, A., Department of Bioimaging Information Analysis, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Hanaoka, H., Department of Bioimaging Information Analysis, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Hishiki, T., Department of Biochemistry, Keio University School of Medicine, 35 Shinano-Machi, Shinjuku-Ku, Tokyo, 160-8582, Japan, Clinical and Translational Research Center, Keio University School of Medicine, 35 Shinano-Machi, Shinjuku-Ku, Tokyo, 160-8582, Japan; Hayakawa, N., Department of Biochemistry, Keio University School of Medicine, 35 Shinano-Machi, Shinjuku-Ku, Tokyo, 160-8582, Japan, Clinical and Translational Research Center, Keio University School of Medicine, 35 Shinano-Machi, Shinjuku-Ku, Tokyo, 160-8582, Japan; Koitabashi, N., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Sunaga, H., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan, Center for Liberal Arts and Sciences, Ashikaga University, 268-1 Omae-Machi, Ashikaga, 326-8558, Japan; Matsui, H., Department of Laboratory Sciences, Gunma University Graduate School of Health Sciences, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Kurabayashi, M., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Iso, T., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan, Department of Medical Technology and Clinical Engineering, Gunma University of Health and Welfare, 191-1 Kawamagari-Machi, Maebashi, 371-0823, Japan |
Cardiac dysfunction is induced by multifactorial mechanisms in diabetes. Deranged fatty acid (FA) utilization, known as lipotoxicity, has long been postulated as one of the upstream events in the development of diabetic cardiomyopathy. CD36, a transmembrane glycoprotein, plays a major role in FA uptake in the heart. CD36 knockout (CD36KO) hearts exhibit reduced rates of FA transport with marked enhancement of glucose use. In this study, we explore whether reduced FA use by CD36 ablation suppresses the development of streptozotocin (STZ)-induced diabetic cardiomyopathy. We found that cardiac contractile dysfunction had deteriorated 16 weeks after STZ treatment in CD36KO mice. Although accelerated glucose uptake was not reduced in CD36KO-STZ hearts, the total energy supply, estimated by the pool size in the TCA cycle, was significantly reduced. The isotopomer analysis with13 C6-glucose revealed that accelerated glycolysis, estimated by enrichment of13 C2-citrate and13 C2-malate, was markedly suppressed in CD36KO-STZ hearts. Levels of ceramides, which are cardiotoxic lipids, were not elevated in CD36KO-STZ hearts compared to wild-type-STZ ones. Furthermore, increased energy demand by transverse aortic constriction resulted in synergistic exacerbation of contractile dysfunction in CD36KO-STZ mice. These findings suggest that CD36KO-STZ hearts are energetically compromised by reduced FA use and suppressed glycolysis; therefore, the limitation of FA utilization is detrimental to cardiac energetics in this model of diabetic cardiomyopathy. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
CD36; Ceramide; Diabetic cardiomyopathy; Fatty acid; Glucose; Metabolomics; Streptozotocin |
CD36 antigen; fatty acid; fluorodeoxyglucose f 18; formaldehyde; glucose; glycogen; insulin; isoflurane; liquid nitrogen; streptozocin; triacylglycerol; animal cell; animal experiment; animal model; animal tissue; aortic constriction; Article; biochemical analysis; capillary electrophoresis; centrifugation; citric acid cycle; controlled study; diabetes mellitus; diabetic cardiomyopathy; energy resource; enzyme linked immunosorbent assay; fatty acid blood level; fatty acid transport; fibrosis; genotype; glucose blood level; glucose transport; glycogen level; heart disease; heart function; heart rate; hemodynamics; knockout gene; knockout mouse; lactate blood level; liquid chromatography-mass spectrometry; male; mass spectrometry; Masson trichrome stain; metabolic fingerprinting; metabolome; |
MDPI |
22181989 |
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Article |
Q2 |
1109 |
3744 |
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