|
No records
|
|
31 |
Nusanti S., Dearaini, Bani A.P., Kartasasmita A.S., Ichsan A.M., Virgana R., Anggraini N., Rahayu T., Irfani I., Edwar L., Rifada M., Yudantha A.R., Ismail M.A., Komaratih E., Wildan A., Knoch A.M.H. |
57189727162;57386841000;53663268800;37002851300;57218514954;56922099400;57387397200;57208305374;57201131541;55695047800;55249679300;55489644900;57386650700;57204192624;57205025156;57386841100; |
Delivering a modified continuous objective structured clinical examination for ophthalmology residents through a hybrid online method |
2021 |
Korean Journal of Medical Education |
33 |
4 |
|
419 |
430 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121800362&doi=10.3946%2fkjme.2021.210&partnerID=40&md5=f12d396df59aa176538ef352c359c609 |
Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Ophthalmology, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia; Department of Ophthalmology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Department of Ophthalmology, Faculty of Medicine, Airlangga University, Surabaya, Indonesia; Department of Ophthalmology, Faculty of Medicine, Diponegoro University, Semarang, Indonesia |
Nusanti, S., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Dearaini, Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Bani, A.P., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kartasasmita, A.S., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia; Ichsan, A.M., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Virgana, R., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia; Anggraini, N., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahayu, T., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Irfani, I., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia; Edwar, L., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rifada, M., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yudantha, A.R., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ismail, M.A., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Komaratih, E., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Airlangga University, Surabaya, Indonesia; Wildan, A., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Knoch, A.M.H., Indonesian College of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Ophthalmology, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia |
Since coronavirus disease 2019 was declared a global pandemic by the World Health Organization, it has become a challenging situation to continue medical education, including in Indonesia. The situation prohibited face-to-face (direct) educational activities in clinical settings, therefore also postponing examinations involving especially procedural skills. Adaptations were urgently needed to maintain the delivery of high-stake examinations to sustain the number of ophthalmology graduates and the continuation of eye health service. Objective structured clinical examination (OSCE) has been one of our widely used method to assess clinical competencies for ophthalmology residents, and is the one method that involves gatherings, close contact of examiners, examinees and patients, therefore the most difficult to adjust. Pandemic challenges brought technical changes in our delivering the OSCE to online, maximizing digital platforms of meetings, while still concerned to guarding the safety of candidates, patients and staffs. OSCE scenarios were also made as timely efficient as possible by changing continuous station models to a cascade one. The purpose of this article is to document our experience in conducting a feasible and reproducible OSCE in this pandemic era filled with limitations. © The Korean Society of Medical Education. All rights reserved. |
COVID-19; Education; Internship and residency; Methods; Ophthalmology / education |
clinical competence; education; health service; human; medical education; ophthalmology; Clinical Competence; COVID-19; Educational Measurement; Health Services; Humans; Internship and Residency; Ophthalmology; SARS-CoV-2 |
Korean Society of Medical Education |
2005727X |
|
34875158 |
Article |
Q4 |
175 |
21057 |
|
|
|
32 |
Yo E.C., Witjaksono A.N., Fitriani D.Y., Werdhani R.A., Parikesit D. |
57213188908;57224351398;57224589606;57189088848;57163830300; |
Evaluating knowledge retention and perceived benefits of medical webinar for professional development among Indonesian physicians |
2021 |
Korean Journal of Medical Education |
33 |
4 |
|
381 |
391 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121761218&doi=10.3946%2fkjme.2021.206&partnerID=40&md5=88879a0b2b85137bc0337e9c3aa3de9b |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ophthalmology Medical Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, Depok, Indonesia; Occupational Medicine Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, Depok, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Urology Medical Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, Depok, Indonesia |
Yo, E.C., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Witjaksono, A.N., Ophthalmology Medical Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, Depok, Indonesia; Fitriani, D.Y., Occupational Medicine Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, Depok, Indonesia, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Werdhani, R.A., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Parikesit, D., Urology Medical Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, Depok, Indonesia |
Purpose: To assess knowledge retention of physicians after participating in a webinar series and its perceived benefits on daily practice and career development. Methods: The webinar series comprised six separate webinars about daily practice. Online questionnaires were sent to all participating physicians via email 3 months after the webinars. The questionnaire assessed knowledge retention through the difference between initial and follow-up post-test as well as the webinar series' benefits on daily practice and career development. Participants' demographic information, including their age, gender, education, year of graduation, and work details, were collected to compare outcomes between demographic groups. Results: A total of 689 responses were gathered, and 622 were analyzed. At follow-up, the median knowledge score was significantly lower than the initial median knowledge score (Z=-6.973, p<0.001). Participants' perception of the webinar series' benefits on daily practice and career development was very positive. A significant weak negative correlation was found between age and knowledge score at follow-up (rs=-0.157, p<0.001). Physicians who graduated more recently and worked for less than 3 years scored significantly higher on knowledge tests at follow-up. Meanwhile, perception score towards webinar series' benefits on daily practice was significantly higher among physicians with more extended work history. Male physicians scored significantly higher on perception score towards webinar series' benefits on career development. Conclusion: Online continuing medical education programs like webinars can encourage physicians to maintain their competence, but further research on improving knowledge retention over time is necessary. Overall, physicians perceived webinars to be beneficial for their professional development. © The Korean Society of Medical Education. All rights reserved. |
Continuing medical education; Knowledge retention; Physicians; Professional development; Videoconference |
human; Indonesia; male; medical education; physician; questionnaire; Education, Medical, Continuing; Humans; Indonesia; Male; Physicians; Surveys and Questionnaires |
Korean Society of Medical Education |
2005727X |
|
34875154 |
Article |
Q4 |
175 |
21057 |
|
|
|
33 |
Umbarawan Y., Kawakami R., Syamsunarno M.R.A.A., Obinata H., Yamaguchi A., Hanaoka H., Hishiki T., Hayakawa N., Koitabashi N., Sunaga H., Matsui H., Kurabayashi M., Iso T. |
57196077830;57210447153;36142388300;6506181723;23394341400;56020036100;7004072867;57221461061;6603109711;55061468300;57212330485;7103371684;7003498756; |
Reduced fatty acid use from cd36 deficiency deteriorates streptozotocin-induced diabetic cardiomyopathy in mice |
2021 |
Metabolites |
11 |
12 |
881 |
|
|
|
1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121605641&doi=10.3390%2fmetabo11120881&partnerID=40&md5=50b9a38996d07912da5741dbe717f2f0 |
Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya no. 6, Jakarta, 10430, Indonesia; Department of Biomedical Sciences, Universitas Padjadjaran, Jl. Raya Bandung Sumedang KM 21, Jatinangor, 45363, Indonesia; Education and Research Support Center, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Department of Bioimaging Information Analysis, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Department of Biochemistry, Keio University School of Medicine, 35 Shinano-Machi, Shinjuku-Ku, Tokyo, 160-8582, Japan; Clinical and Translational Research Center, Keio University School of Medicine, 35 Shinano-Machi, Shinjuku-Ku, Tokyo, 160-8582, Japan; Center for Liberal Arts and Sciences, Ashikaga University, 268-1 Omae-Machi, Ashikaga, 326-8558, Japan; Department of Laboratory Sciences, Gunma University Graduate School of Health Sciences, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Department of Medical Technology and Clinical Engineering, Gunma University of Health and Welfare, 191-1 Kawamagari-Machi, Maebashi, 371-0823, Japan |
Umbarawan, Y., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya no. 6, Jakarta, 10430, Indonesia; Kawakami, R., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Syamsunarno, M.R.A.A., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan, Department of Biomedical Sciences, Universitas Padjadjaran, Jl. Raya Bandung Sumedang KM 21, Jatinangor, 45363, Indonesia; Obinata, H., Education and Research Support Center, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Yamaguchi, A., Department of Bioimaging Information Analysis, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Hanaoka, H., Department of Bioimaging Information Analysis, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Hishiki, T., Department of Biochemistry, Keio University School of Medicine, 35 Shinano-Machi, Shinjuku-Ku, Tokyo, 160-8582, Japan, Clinical and Translational Research Center, Keio University School of Medicine, 35 Shinano-Machi, Shinjuku-Ku, Tokyo, 160-8582, Japan; Hayakawa, N., Department of Biochemistry, Keio University School of Medicine, 35 Shinano-Machi, Shinjuku-Ku, Tokyo, 160-8582, Japan, Clinical and Translational Research Center, Keio University School of Medicine, 35 Shinano-Machi, Shinjuku-Ku, Tokyo, 160-8582, Japan; Koitabashi, N., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Sunaga, H., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan, Center for Liberal Arts and Sciences, Ashikaga University, 268-1 Omae-Machi, Ashikaga, 326-8558, Japan; Matsui, H., Department of Laboratory Sciences, Gunma University Graduate School of Health Sciences, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Kurabayashi, M., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan; Iso, T., Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, 371-8511, Japan, Department of Medical Technology and Clinical Engineering, Gunma University of Health and Welfare, 191-1 Kawamagari-Machi, Maebashi, 371-0823, Japan |
Cardiac dysfunction is induced by multifactorial mechanisms in diabetes. Deranged fatty acid (FA) utilization, known as lipotoxicity, has long been postulated as one of the upstream events in the development of diabetic cardiomyopathy. CD36, a transmembrane glycoprotein, plays a major role in FA uptake in the heart. CD36 knockout (CD36KO) hearts exhibit reduced rates of FA transport with marked enhancement of glucose use. In this study, we explore whether reduced FA use by CD36 ablation suppresses the development of streptozotocin (STZ)-induced diabetic cardiomyopathy. We found that cardiac contractile dysfunction had deteriorated 16 weeks after STZ treatment in CD36KO mice. Although accelerated glucose uptake was not reduced in CD36KO-STZ hearts, the total energy supply, estimated by the pool size in the TCA cycle, was significantly reduced. The isotopomer analysis with13 C6-glucose revealed that accelerated glycolysis, estimated by enrichment of13 C2-citrate and13 C2-malate, was markedly suppressed in CD36KO-STZ hearts. Levels of ceramides, which are cardiotoxic lipids, were not elevated in CD36KO-STZ hearts compared to wild-type-STZ ones. Furthermore, increased energy demand by transverse aortic constriction resulted in synergistic exacerbation of contractile dysfunction in CD36KO-STZ mice. These findings suggest that CD36KO-STZ hearts are energetically compromised by reduced FA use and suppressed glycolysis; therefore, the limitation of FA utilization is detrimental to cardiac energetics in this model of diabetic cardiomyopathy. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
CD36; Ceramide; Diabetic cardiomyopathy; Fatty acid; Glucose; Metabolomics; Streptozotocin |
CD36 antigen; fatty acid; fluorodeoxyglucose f 18; formaldehyde; glucose; glycogen; insulin; isoflurane; liquid nitrogen; streptozocin; triacylglycerol; animal cell; animal experiment; animal model; animal tissue; aortic constriction; Article; biochemical analysis; capillary electrophoresis; centrifugation; citric acid cycle; controlled study; diabetes mellitus; diabetic cardiomyopathy; energy resource; enzyme linked immunosorbent assay; fatty acid blood level; fatty acid transport; fibrosis; genotype; glucose blood level; glucose transport; glycogen level; heart disease; heart function; heart rate; hemodynamics; knockout gene; knockout mouse; lactate blood level; liquid chromatography-mass spectrometry; male; mass spectrometry; Masson trichrome stain; metabolic fingerprinting; metabolome; |
MDPI |
22181989 |
|
|
Article |
Q2 |
1109 |
3744 |
|
|
|
34 |
Gustiananda M., Sulistyo B.P., Agustriawan D., Andarini S. |
6507570171;57215020738;55382929300;8716259500; |
Immunoinformatics analysis of sars-cov-2 orf1ab polyproteins to identify promiscuous and highly conserved t-cell epitopes to formulate vaccine for indonesia and the world population |
2021 |
Vaccines |
9 |
12 |
1459 |
|
|
|
1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121528747&doi=10.3390%2fvaccines9121459&partnerID=40&md5=e6eaaf1e02bbe5e81bf5d0e390d38566 |
Department of Biomedicine, School of Life Sciences, Indonesia International Institute for Life Sciences, Jl. Pulomas Barat Kav 88, Jakarta, 13210, Indonesia; Department of Bioinformatics, School of Life Sciences, Indonesia International Institute for Life Sciences, Jl. Pulomas Barat Kav 88, Jakarta, 13210, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia, Persahabatan Hospital, Jl Persahabatan Raya 1, Jakarta, 13230, Indonesia |
Gustiananda, M., Department of Biomedicine, School of Life Sciences, Indonesia International Institute for Life Sciences, Jl. Pulomas Barat Kav 88, Jakarta, 13210, Indonesia; Sulistyo, B.P., Department of Biomedicine, School of Life Sciences, Indonesia International Institute for Life Sciences, Jl. Pulomas Barat Kav 88, Jakarta, 13210, Indonesia; Agustriawan, D., Department of Bioinformatics, School of Life Sciences, Indonesia International Institute for Life Sciences, Jl. Pulomas Barat Kav 88, Jakarta, 13210, Indonesia; Andarini, S., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia, Persahabatan Hospital, Jl Persahabatan Raya 1, Jakarta, 13230, Indonesia |
SARS-CoV-2 and its variants caused the COVID-19 pandemic. Vaccines that target conserved regions of SARS-CoV-2 and stimulate protective T-cell responses are important for reducing symptoms and limiting the infection. Seven cytotoxic (CTL) and five helper T-cells (HTL) epitopes from ORF1ab were identified using NetCTLpan and NetMHCIIpan algorithms, respectively. These epitopes were generated from ORF1ab regions that are evolutionary stable as reflected by zero Shannon’s entropy and are presented by 56 human leukocyte antigen (HLA) Class I and 22 HLA Class II, ensuring good coverage for the Indonesian and world population. Having fulfilled other criteria such as immunogenicity, IFNγ inducing ability, and non-homology to human and microbiome peptides, the epitopes were assembled into a vaccine construct (VC) together with β-defensin as adjuvant and appropriate linkers. The VC was shown to have good physicochemical characteristics and capability of inducing CTL as well as HTL responses, which stem from the engagement of the vaccine with toll-like receptor 4 (TLR4) as revealed by docking simulations. The most promiscuous peptide899WSMATYYLF907 was shown via docking simulation to interact well with HLA-A*24:07, the most predominant allele in Indonesia. The data presented here will contribute to the in vitro study of T-cell epitope mapping and vaccine design in Indonesia. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Cytotoxic T-cells; Helper T-cells; HLA-A*24:07; Human leukocyte antigen; Immunoinformatics; Multi-epitope peptide-based vaccine; SARS-CoV-2; T-cell epitopes |
epitope; gamma interferon; HLA A antigen; HLA antibody; T lymphocyte receptor; toll like receptor 4; allele; allergenicity; amino acid sequence; antigenicity; Article; binding affinity; CD8+ T lymphocyte; controlled study; cytotoxic T lymphocyte; endoplasmic reticulum; entropy; epitope mapping; gene frequency; gene structure; HLA typing; human; human cell; hydrophilicity; immune response; immunogenicity; immunoinformatics; Indonesia; microbiome; molecular docking; open reading frame; peptide synthesis; protein interaction; protein secondary structure; protein structure; sequence alignment; sequence analysis; sequence homology; Severe acute respiratory syndrome coronavirus 2; vaccination |
MDPI |
2076393X |
|
|
Article |
Q1 |
1296 |
2913 |
|
|
|
35 |
Dwijayanti A., Fitrianto A.I., Boediono A., Setiati S., Suyatna F.D. |
55743787900;57377401300;9040094200;14325991900;56039633100; |
Mesenchymal stem cells administration in aged male rats increases testosterone and lower TNF-α levels |
2021 |
International Medical Journal |
28 |
6 |
|
601 |
603 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121461058&partnerID=40&md5=bbf2100ed3003ab64dcb298ba7d9f029 |
Doctoral Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Physiology, and Pharmacology, Faculty of Veterinary Medicine, Bogor Agricultural University, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Dwijayanti, A., Doctoral Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Fitrianto, A.I., Department of Anatomy, Physiology, and Pharmacology, Faculty of Veterinary Medicine, Bogor Agricultural University, Indonesia; Boediono, A., Department of Anatomy, Physiology, and Pharmacology, Faculty of Veterinary Medicine, Bogor Agricultural University, Indonesia; Setiati, S., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Suyatna, F.D., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Treatment for sex hormone depletion along with chronic inflammation would be beneficial for aging males. Mesenchymal stem cells (MSC) are known for their immunomodulatory activities and differentiation ability in regenerative medicine. Whether MSC could influence both testosterone and pro-inflammatory marker in aging males is uncertain. This study aimed to explore the effects of human umbilical mesenchymal stem cell (hUCMSC) on testosterone, tumor necrosis factor-alpha (TNF-α), and creatinine levels in aged rats. Methods: The hUCMSC was administered to aged male Sprague-Dawley rats (24 months old). After four injections of 1 mil-lion per kg body weight in 3-month intervals, the rats were sacrificed, and serum was collected for biochemical examinations. Results: The hUCMSC administrations increased the testosterone level almost three-fold and decreased the TNF-α level. Moreover, the high testosterone level was strongly correlated with low TNF-α level (p = 0.013; r =-0.863) in aged male rats. These results were following our previous report, which showed that the hUCMSC increased the number of Leydig cells. Serum creatinine levels in the treatment group were slightly increased but were still within the normal limit. Conclusion: The hUCMSC treatment in aged male rats tends to increase testosterone levels and lower TNF-α levels. © 2021 Japan University of Health Sciences & Japan International Cultural Exchange Foundation. |
Aging; Mesenchymal stem cell; Testosterone; TNF-α |
creatinine; sex hormone; testosterone; tumor necrosis factor; aged; aging; animal cell; animal experiment; animal model; animal tissue; Article; body weight; controlled study; creatinine blood level; creatinine clearance; female; gene expression; Leydig cell; male; mesenchymal stem cell; nonhuman; protein expression; rat; regenerative medicine; Sprague Dawley rat; testosterone blood level |
Japan International Cultural Exchange Foundation |
13412051 |
|
|
Article |
Q4 |
183 |
20490 |
|
|
|
36 |
Djusad S., Meutia A.P., Tunggadewi S.A., Sari Y.M., Hakim S., Priyatini T., Moegni F., Santoso B.I. |
57192276788;57203368133;57377695800;57217020003;57192276095;57192265423;55450456100;56653822500; |
Genital self-image as predictor of sexual dysfunction in women with pelvic organ prolapse in Indonesia |
2021 |
Women's Health |
17 |
|
|
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121423948&doi=10.1177%2f17455065211066019&partnerID=40&md5=607bdce156595c4225e7b7fef7a1b89c |
Division of Urogynecology and Reconstructive, Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Fatmawati Hospital Jakarta Indonesia, Jakarta, Indonesia |
Djusad, S., Division of Urogynecology and Reconstructive, Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Fatmawati Hospital Jakarta Indonesia, Jakarta, Indonesia; Meutia, A.P., Division of Urogynecology and Reconstructive, Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Fatmawati Hospital Jakarta Indonesia, Jakarta, Indonesia; Tunggadewi, S.A., Division of Urogynecology and Reconstructive, Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Fatmawati Hospital Jakarta Indonesia, Jakarta, Indonesia; Sari, Y.M., Division of Urogynecology and Reconstructive, Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Fatmawati Hospital Jakarta Indonesia, Jakarta, Indonesia; Hakim, S., Division of Urogynecology and Reconstructive, Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Fatmawati Hospital Jakarta Indonesia, Jakarta, Indonesia; Priyatini, T., Division of Urogynecology and Reconstructive, Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Fatmawati Hospital Jakarta Indonesia, Jakarta, Indonesia; Moegni, F., Division of Urogynecology and Reconstructive, Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Fatmawati Hospital Jakarta Indonesia, Jakarta, Indonesia; Santoso, B.I., Division of Urogynecology and Reconstructive, Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Fatmawati Hospital Jakarta Indonesia, Jakarta, Indonesia |
Background: The incidence of sexual dysfunction increases in women with pelvic organ prolapse. In addition to physical factors, other important components that influence each other in sexual dysfunction are psychological aspects and genital self-image. Sociocultural factors also affect individual sexuality and sexual behavior. Until now, there are no data and the relationship between genital self-image and sexual dysfunction in pelvic organ prolapse is not known in Indonesia. Objective: This study aims to analyze the correlation of genital self-image with sexual dysfunction in women with pelvic organ prolapse. Methods: In this cross-sectional study, 113 consecutive women with pelvic organ prolapse were selected in urogynecology referral centers in Jakarta. Demographic data, physical examination, and guided interviews were filled in to complete the Female Sexual Function Index and Female Genital Self-Image Scale-7 questionnaires. Preliminary research has been carried out in the form of language translation and cultural validation of the Indonesian version of the Female Genital Self-Image Scale-7 questionnaires. Results: There is a significant correlation between genital self-image and sexual dysfunction, where the lower Female Genital Self-Image Scale-7 score significantly predicts the lower Female Sexual Function Index score (p < 0.000; odds ratio: 14.17). Conclusion: Genital self-image is the main variable that affects sexual function in women with pelvic organ prolapse. It is necessary to evaluate and treat genital self-image because sexual function is an integrated component of quality of life. © The Author(s) 2021. |
eastern sexuality; Female Genital Self-Image Scale; female sexual dysfunction; Female Sexual Function Index; genital self-image; pelvic organ prolapse |
adult; Article; body mass; cancer staging; constipation; cross-sectional study; cystocele; depression; female; female sexual dysfunction; gynecologic surgery; human; major clinical study; marriage; pelvic examination; pelvic floor disorder; pelvic organ prolapse; psychometry; questionnaire; sexual behavior; sexual dysfunction; sexual function; sleep quality; urinary tract infection; vaginal delivery; genital system; Indonesia; pelvic organ prolapse; psychology; quality of life; Cross-Sectional Studies; Female; Genitalia; Humans; Indonesia; Pelvic Organ Prolapse; Quality of Life; Sexual Behavior; Surveys and Questionnaires |
SAGE Publications Ltd |
17455057 |
|
34913375 |
Article |
Q1 |
1363 |
2670 |
|
|
|
37 |
Tamin S., Adham M., Noer A., Supriana N., Bardosono S. |
57195719598;14024202100;57370851100;8438653200;21933841000; |
Upright epiglottis prevents aspiration in patients with nasopharyngeal carcinoma post-chemoradiation |
2021 |
PLoS ONE |
16 |
12 December |
e0261110 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121054797&doi=10.1371%2fjournal.pone.0261110&partnerID=40&md5=c09f68482b8e097a20b06089e0d5849e |
Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Radio Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Nutrition Science, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Tamin, S., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Adham, M., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Noer, A., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Supriana, N., Department of Radio Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Bardosono, S., Department of Nutrition Science, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
NPC is the most widely found malignant tumor in the head and neck region in Indonesia. Chemoradiation therapy for NPC can induce swallowing disorders (dysphagia) that adversely affects a patients quality of life. This study aimed to assess the swallowing process by flexible endoscopic evaluation of swallowing in patients with nasopharyngeal carcinoma after chemoradiation. Thirty-nine patients with NPC who had chemoradiation therapy more than one month previously underwent flexible endoscopic evaluation of swallowing and were assessed for oral transport time, sensation, standing-secretion, pre-swallowing leakage, residue, penetration, aspiration, and silent aspiration. The most common structural abnormalities were an upright and swollen epiglottis (89.4%), poor oral hygiene, and velopharyngeal closure defects (56.4%). This examination also revealed a mild degree of standing secretion (38.5%) and aspiration (10.3%). No penetration was observed in 64.1% of the patients, and no silent aspiration was observed in any of the patients. A severe degree of residue (45.7%) was observed when administering oatmeal, while the residue was mild to moderate when administering gastric rice, crackers, and milk. The residue changed to a mild degree (32.3%-51.4%) in all food administrations after the watering maneuver. The highest penetration was noted after oatmeal administration (42.8%), and the highest aspiration was found after milk administration (8.6%). Standing secretion in almost all patients was caused by hyposensitivity of the hypopharynx. Persistent residue and hyposensitivity of the hypopharynx led to aspiration. The low percentage of aspiration and silent aspiration might have been caused by the upright and swollen epiglottis that prevented aspiration. Poor oral hygiene and a dry mouth led to prolonged oral transport. Therefore, most patients had hypopharyngeal abnormalities in the form of a swollen and upright epiglottis. Secretion and food residue were also detected. Drinking helps to expedite the swallowing process by facilitating oral phase transport and reducing residues. © 2021 Tamin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
|
acid aspiration; adult; adverse event; chemoradiotherapy; digestive tract endoscopy; dysphagia; female; human; male; middle aged; nasopharynx carcinoma; nasopharynx tumor; pathology; pathophysiology; procedures; Adult; Chemoradiotherapy; Deglutition Disorders; Endoscopy, Digestive System; Female; Humans; Male; Middle Aged; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Respiratory Aspiration |
Public Library of Science |
19326203 |
|
34882745 |
Article |
Q1 |
990 |
4434 |
|
|
|
38 |
Dhelika R., Hadi A.F., Yusuf P.A. |
55536628000;57368046500;57192156597; |
Development of a motorized hospital bed with swerve drive modules for holonomic mobility |
2021 |
Applied Sciences (Switzerland) |
11 |
23 |
1356 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120877522&doi=10.3390%2fapp112311356&partnerID=40&md5=7c16eb6fe630116772c69c4d02b4bd9f |
Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI, Depok, 16424, Indonesia; Department of Medical Physics/Medical Technology Core Cluster IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Dhelika, R., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI, Depok, 16424, Indonesia; Hadi, A.F., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI, Depok, 16424, Indonesia; Yusuf, P.A., Department of Medical Physics/Medical Technology Core Cluster IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
In hospitals; transferring patients using hospital beds is time consuming and inefficient. Additionally; the task of frequently pushing and pulling beds poses physical injury risks to nurses and caregivers. Motorized hospital beds with holonomic mobility have been previously proposed. However; most such beds come with complex drivetrain which makes them costly and hinders larger‐scale adoption in hospitals. In this study; a motorized hospital bed that utilizes a swerve drive mechanism is proposed. The design takes into account simplicity which would allow for minimum modification of the existing beds. Two DC motors for steering and propulsion are used for a single swerve drive module. The control of the propulsion motor is achieved by a combination of trajectory planning based on quintic polynomials and PID control. Further; the control performance of the proposed bed was evaluated; and the holonomic mobility of its prototype was successfully demonstrated. An average error of less than 3% was obtained for motion with a constant velocity; however; larger values in the range of 15% were observed for other conditions, such as accelerating and decelerating. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Hospital bed; Mechatronics; PID control; Swerve drive; Trajectory planning |
|
MDPI |
20763417 |
|
|
Article |
Q2 |
435 |
11324 |
|
|
|
39 |
Marofi F., Kozlitina I.A., Margiana R., Bahramali M., Suksatan W., Abdelbasset W.K., Chupradit S., Nasimi M., Maashi M.S. |
57199650994;57428645300;56685900600;57365531600;57219950613;57208873763;57211329338;57189347372;57220613490; |
MSCs and their exosomes: a rapidly evolving approach in the context of cutaneous wounds therapy |
2021 |
Stem Cell Research and Therapy |
12 |
1 |
597 |
|
|
|
1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120732728&doi=10.1186%2fs13287-021-02662-6&partnerID=40&md5=1bb65103a59b38f350d6be8213b4dad8 |
Immunology Research Center (IRC), Tabriz University of Medical Sciences, Tabriz, Iran; Sechenov First Moscow State Medical University, Moscow, Russian Federation; Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Master’s Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Biotechnology Department, University of Tehran, Tehran, Iran; Faculty of Nursing, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, 10210, Thailand; Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia; Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt; Department of Occupational Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, 50200, Thailand; Tehran University of Medical Sciences, Tehran, Iran; Stem Cells and Regenerative Medicine Unit at King Fahad Medical Research Centre, Jeddah, Saudi Arabia |
Marofi, F., Immunology Research Center (IRC), Tabriz University of Medical Sciences, Tabriz, Iran; Kozlitina, I.A., Sechenov First Moscow State Medical University, Moscow, Russian Federation; Margiana, R., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Master’s Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Bahramali, M., Biotechnology Department, University of Tehran, Tehran, Iran; Suksatan, W., Faculty of Nursing, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, 10210, Thailand; Abdelbasset, W.K., Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia, Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt; Chupradit, S., Department of Occupational Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, 50200, Thailand; Nasimi, M., Tehran University of Medical Sciences, Tehran, Iran; Maashi, M.S., Stem Cells and Regenerative Medicine Unit at King Fahad Medical Research Centre, Jeddah, Saudi Arabia |
Currently, mesenchymal stem/stromal stem cell (MSC) therapy has become a promising option for accelerating cutaneous wound healing. In vivo reports have outlined the robust competences of MSCs to offer a solid milieu by inhibition of inflammatory reactions, which in turn, enables skin regeneration. Further, due to their great potential to stimulate angiogenesis and also facilitate matrix remodeling, MSCs hold substantial potential as future therapeutic strategies in this context. The MSCs-induced wound healing is thought to mainly rely on the secretion of a myriad of paracrine factors in addition to their direct differentiation to skin-resident cells. Besides, MSCs-derived exosomes as nanoscale and closed membrane vesicles have recently been suggested as an effective and cell-free approach to support skin regeneration, circumventing the concerns respecting direct application of MSCs. The MSCs-derived exosomes comprise molecular components including lipid, proteins, DNA, microRNA, and also mRNA, which target molecular pathways and also biological activities in recipient cells (e.g., endothelial cell, keratinocyte, and fibroblast). The secreted exosome modifies macrophage activation, stimulates angiogenesis, and instigates keratinocytes and dermal fibroblast proliferations as well as migrations concurrently regulate inherent potential of myofibroblast for adjustment of turnover of the ECM. In the present review, we will focus on the recent findings concerning the application of MSCs and their derivative exosome to support wound healing and skin regeneration, with special focus on last decade in vivo reports. © 2021, The Author(s). |
Cutaneous wounds; Differentiation; Exosome; Mesenchymal stem/stromal stem cell (MSC); Paracrine factors |
angiopoietin 1; angiopoietin 2; biomaterial; chemokine receptor CCR2; chemokine receptor CCR3; chemokine receptor CXCR1; chemokine receptor CXCR4; collagen type 1; collagen type 3; elastin; fibroblast growth factor 2; gelatinase B; immunoglobulin enhancer binding protein; interleukin 1; interleukin 6; microRNA; microRNA 21 5p; mitogen activated protein kinase; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; platelet derived growth factor beta receptor; platelet endothelial cell adhesion molecule 1; stromal cell derived factor 1; toll like receptor 4; tumor necrosis factor; unclassified drug; vasculotropin; vasculotropin C; angiogenesis; biogenesis; cell differentiation; cell migration; cell proliferation; diabetic foot; endothelium cell; exosome; extracellular matrix; fibroblast; h |
BioMed Central Ltd |
17576512 |
|
34863308 |
Review |
Q1 |
1599 |
2021 |
|
|
|
40 |
Darwis P., Putri R.N., Elfizri Z. |
57359231100;57359840400;57221703181; |
Transarterial endovascular coil embolization in managing intractable bleeding from fibular artery: A case report |
2021 |
International Journal of Surgery Case Reports |
89 |
|
106618 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120414515&doi=10.1016%2fj.ijscr.2021.106618&partnerID=40&md5=5c625f8d9596a6f6288c4138304dfd2e |
Division of Vascular and Endovascular Surgery, Department of Surgery, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Darwis, P., Division of Vascular and Endovascular Surgery, Department of Surgery, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Putri, R.N., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Elfizri, Z., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Introduction: Pseudoaneurysms of the fibular artery are rare. Recently, endovascular techniques have been preferred over open surgery. Case presentation: A 50-year-old male patient complained of recurrent bleeding from surgical wounds that had been present for one month. The patient sustained an open cruris fracture. No source of active bleeding was found at the time of exploration. The patient has then performed angiography with coiling and showed a pseudoaneurysm originating from the left fibular artery branch. Surgical debridement and external fixation were performed one day after the angiography and embolization procedure. The patient was discharged on the third day, and there has been no recurrent bleeding ever since. Case discussion: A pseudoaneurysm can be thought of as one of the intractable bleeding causes. Recently, the endovascular technique has been commonly used as an alternative treatment if we did not find the source of bleeding in exploration. Many kinds of the literature showed the success of using non-surgical management, especially the coil embolization as the patient received. Conclusion: In the management of pseudoaneurysm following trauma which cannot be found in open surgery, an endovascular technique like coil embolization can be the alternative method. © 2021 The Authors |
Coil embolization; Endovascular technique; Fibular artery; Open fracture; Pseudoaneurysm |
antibiotic agent; adult; aneurysm size; angiography; arterial embolization; Article; bleeding; case report; clinical article; coil embolization; echography; endovascular surgery; false aneurysm; fracture external fixation; hemoglobin blood level; hospital discharge; human; human tissue; infection; male; middle aged; open reduction (procedure); open surgery; osteosynthesis; pulse wave; surgical debridement; surgical wound; traffic accident; vascular surgeon |
Elsevier Ltd |
22102612 |
|
|
Article |
Q3 |
232 |
17549 |
|
|
