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Kusmardi K., Situmorang N.Y., Zuraidah E., Estuningtyas A., Tedjo A. |
56966625300;57357530500;57357911500;55650360200;57189320451; |
The effect of mahkota dewa (Phaleria macrocarpa) leaf extract on the Mucin 1 expression in mice colonic epithelial cells induced by dextran sodium sulfate (DSS) |
2021 |
Pharmacognosy Journal |
13 |
6 |
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1509 |
1515 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120333886&doi=10.5530%2fPJ.2021.13.181&partnerID=40&md5=668714fd6caa4dce8362e17d7e54ca12 |
Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Drug Development Research Center, Indonesia Medical Education and Resesarch Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Human Cancer Research Center, IMERI, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Kusmardi, K., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Drug Development Research Center, Indonesia Medical Education and Resesarch Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia, Human Cancer Research Center, IMERI, Universitas Indonesia, Jakarta, Indonesia; Situmorang, N.Y., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Zuraidah, E., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Estuningtyas, A., Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tedjo, A., Drug Development Research Center, Indonesia Medical Education and Resesarch Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Inflammatory bowel disease is a chronic inflammation caused by the malignant inflammation response and if not treated, could lead to colorectal cancer. One of the researched treatment is mahkota dewa (Phaleria macrocarpa) leaf extract that has flavonoid compound known to reduce inflammation. This study was aimed to prove that mahkota dewa leaf extract could reduce inflammation of mice colon induced with dextran sodium sulfate (DSS) and observe MUC1 expression from colon epithelial crypt of Lieberkuhn. Methods: This was a laboratory experiment using biological material (paraffin block) taken from 28 mice and divided into 5 groups: normal, aspirin, low and high dose mahkota dewa, and negative control. They were processed into immunohistochemistry and stained microscopic slides. Afterwards, they were observed with 400x magnification and 5 field-of-view of mice colon crypt of lieberkuhn. Then MUC1 expression was counted using ImageJ to obtain mean immunohistochemistry score and analyzed with SPSS. Results: There were significant reduction of MUC1 expressions from normal, aspirin, and high dose mahkota dewa groups compared to the negative control group. The result shown MUC1 expression from high dose mahkota dewa (M=149.90,SD=3.81) and aspirin (M=158.92,SD=5.28) were closer to normal group (M=148.02,SD=5.28). There were no significant results between negative (M=175.39,SD=14.30) and low dose mahkota dewa group (M=149.90,SD=5.02). Conclusion: There was a reduction of MUC1 expression in DSS-induced mice colonic epithelial cells for high dose mahkota dewa group. This shown that high dosage mahkota dewa leaf extract could reduce inflammation like aspirin. © 2021 Phcogj.Com. |
Anti-inflammatory agent; Colon epithelial cell; Inflammatory bowel disease; Mahkota dewa (Phaleria macrocarpa); MUC 1 expression |
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15961 |
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Rusdi N.K., Yuliana W.L., Purwaningsih E.H., Hestiantoro A., Kusmardi K. |
57211475250;57358166800;57186723500;8743255100;56966625300; |
Subchronic toxicity of lunasin targeted extract (ET-Lun) from soybean seed (Glycine max (L.) Merr.): Perspective from liver histopathology, SGOT, and SGPT levels in Sprague Dawley rats |
2021 |
Pharmacognosy Journal |
13 |
6 |
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1384 |
1388 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120333876&doi=10.5530%2fPJ.2021.13.175&partnerID=40&md5=05cdb4c0d35834a5b3b9ce79bf4c1e56 |
Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. DR. Hamka, Jakarta, Indonesia; Department of Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Drug Development Research Cluster, Indonesian Medical Education and Reseach Institute, Universitas INDONESIA, Indonesia; Department Obstetrics and Gynaecology, School of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Human Cancer Research Cluster, Indonesian Medical Education and Reseach Institute, Universitas INDONESIA, Indonesia |
Rusdi, N.K., Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. DR. Hamka, Jakarta, Indonesia; Yuliana, W.L., Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. DR. Hamka, Jakarta, Indonesia; Purwaningsih, E.H., Department of Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Drug Development Research Cluster, Indonesian Medical Education and Reseach Institute, Universitas INDONESIA, Indonesia; Hestiantoro, A., Department Obstetrics and Gynaecology, School of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kusmardi, K., Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Drug Development Research Cluster, Indonesian Medical Education and Reseach Institute, Universitas INDONESIA, Indonesia, Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Human Cancer Research Cluster, Indonesian Medical Education and Reseach Institute, Universitas INDONESIA, Indonesia |
Background: Lunasin Targeted Extract (ET-Lun) has a pharmacology effect in inhibiting inflammation by decreasing COX-2 and iNOS expression. ET-Lun could increase apoptosis and decrease dysplasia (p > 0,05). In addition, ET-Lun could decrease EGFR expression in breast cancer rats. The acute toxicity showed ET-Lun has LD50 more than 5000 mg/kg BW and was practically non-toxic. Objective: this study aimed to determine the subchronic toxicity of ET-Lun. Methods: Male and female Sprague Dawley rats (n=40) were divided into 4 groups, the control group and treatment group ET-Lun dose of 250 mg/Kg BW, 500 mg/kg BW, and 750 mg/kg BW. The ET-Lun was administered for 90 days. On the 91st day, the animals were dissected and examined for SGOT-SGPT levels, liver histopathology, and diameter of the central vein. Results: The SGOT-SGPT levels showed no significant difference between the treatment group and the control group (p > 0.05). On microscopic observation, there was no change or damage to the liver of rats in each group. The diameter of the central vein of the rat liver shows no significant difference between the control and treatment groups. Conclusion: The ET-Lun does not produce adverse effects in liver rats after subchronic treatment. © 2021 Phcogj.Com. |
Liver; Lunasin; SGOT; SGPT; Soybean; Subchronic toxicity |
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EManuscript Technologies |
09753575 |
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15961 |
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Kusmardi K., Hairi B.N., Lubis N.S., Lestari T.W., Intan P.R. |
56966625300;57357912100;57222661567;57208401033;57357912200; |
The effect of sambiloto and spirulina combination on Mucin-1 protein expression in medial colon of Plasmodium berghei ANKA infected mice |
2021 |
Pharmacognosy Journal |
13 |
6 |
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1359 |
1365 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120320780&doi=10.5530%2fPJ.2021.13.172&partnerID=40&md5=1af1902c44df820801a8286e3e589f81 |
Anatomical Pathology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Drug Development Research Cluster, Indonesia Medical Educational and Research Institute, Jakarta, Indonesia; Human Cancer Research Cluster, Indonesia Medical Educational and Research Institute, Jakarta, Indonesia; Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Parasitology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; National Institute of Health Research and Development, Ministry of Health of Indonesia, Jakarta, Indonesia; Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia |
Kusmardi, K., Anatomical Pathology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Drug Development Research Cluster, Indonesia Medical Educational and Research Institute, Jakarta, Indonesia, Human Cancer Research Cluster, Indonesia Medical Educational and Research Institute, Jakarta, Indonesia, Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hairi, B.N., Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Lubis, N.S., Parasitology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Lestari, T.W., National Institute of Health Research and Development, Ministry of Health of Indonesia, Jakarta, Indonesia; Intan, P.R., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia |
Malaria still be health problem in the world, especially in Eastern Indonesia. Malaria’s inflammation and metabolism defect can cause colonic damage, such as enhancement Muc-1 protein expression and goblet cells hyperplasia. Sambiloto and spirulina combination as antiinflammatory and antioxidative agent can prevent medial colon damage Plasmodium berghei ANKA infected mice. The aim of the study to show the effect of sambiloto and spirulina combination on Muc-1 protein activity in medial colon Plasmodium berghei ANKA infected mice. This study use preserve male Swiss Webser mice colonic tissue which has inoculated by Plasmodium berghei ANKA, whose treatment group include positive control (dehyroartemisin piperaquine), negative control (carboxymethil cellulose), AP (sambiloto), AP+ES (sambiloto+spirulina extract), and AP+PS (sambiloto+spirulina powder) and terminated after 28 days of treatment. Colonic tissue was stained with immunohistochemistry and observed using light microscope (400x) in five different field and was analyzed with ImageJ® sowtware, and statisitcal analysis was done with SPSS 20.0. According to One Way ANOVA and Duncan posthoc test, only AP+PS(120,98 ±3,37), which significantly difference between negative control, AP, and AP+ES group. Meanwhile, between DHP, AP+PS group not significantly differenece. Sambiloto extract and spirulina powder combination can reduce Muc-1 protein expression in medial colon Plasmodium berghei ANKA infected mice. © 2021 Phcogj.Com. |
Medial colon; Muc-1; Plasmodium berghei ANKA; Sambiloto; Spirulina |
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09753575 |
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15961 |
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44 |
Erwin U.S., Cahyadi S.D. |
57216822223;57270709000; |
Cryosurgery and vascularized fibular graft reconstruction in proximal tibia osteosarcoma in young children: A case report |
2021 |
International Journal of Surgery Case Reports |
89 |
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106568 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119615646&doi=10.1016%2fj.ijscr.2021.106568&partnerID=40&md5=b9c3277d8c34a16287ddf3ab69a3eb25 |
Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Indonesia; Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Persahabatan General Hospital, Indonesia |
Erwin, U.S., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Indonesia; Cahyadi, S.D., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Persahabatan General Hospital, Indonesia |
Introduction: Osteosarcoma epidemiology in children younger than 5-year-old is very rare. Currently, limb salvage surgery becomes the preferred treatment in osteosarcoma. Wide excision using cryosurgery has been reported as an effective and safe procedure for malignant bone tumors. Case report: A 5-year-old girl was presented with pain and a lump on her right knee. Physical examination showed a solid circumferential mass in the proximal tibia, with limited range of motion due to mass and pain. Osteoblastic lesion with a discrete margin and narrow transition zone on the proximal tibia from plain radiograph and magnetic resonance imaging (MRI) examination. Histopathological examination suggested osteosarcoma with a giant cell rich osteosarcoma subtype. Three cycles of neoadjuvant chemotherapy was conducted with cisplatin, ifosfamide, and adriamycin. We performed limb salvage surgery by wide excision with cryosurgery and vascularized fibular graft reconstruction. Wide excision was performed with the respect to preserve the epiphyseal plate. The proximal tibia segment was recycled using liquid nitrogen and re-implanted, fixed with a locking 2.7 mm T-plate and a straight reconstruction 2.7 mm reconstruction plate. Vascularized fibular graft was used to fill the bone defect on the medial side. Post-operative radiograph showed the plate and screws are well-fixated and the post-operative histopathological examination confirmed the diagnosis of conventional osteosarcoma HUVOS I. There was no post-operative complication observed, and the functional outcome was good. Conclusions: Cryosurgery and vascularized fibular graft is a viable reconstructive option for proximal tibia osteosarcoma in very young children. © 2021 |
Cryosurgery; Osteosarcoma; Vascularized fibular graft; Very young children |
cisplatin; doxorubicin; gentamicin; ifosfamide; liquid nitrogen; Article; case report; child; clinical article; cryosurgery; epiphysis plate; female; fibula graft; histopathology; human; human cell; human tissue; knee pain; knee radiography; limb salvage; multiple cycle treatment; neoadjuvant chemotherapy; nuclear magnetic resonance imaging; osteosarcoma; physical examination; preschool child; proximal tibia; range of motion; surgical technique; treatment outcome; wide excision |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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45 |
Pontoh L.A., Dilogo I.H., Rahyussalim A.J., Widodo W., Pandapotan Hutapea R.E., Fiolin J. |
57192907426;56161962800;55212166100;57208941551;57344880100;57194498274; |
Evaluation of patellar dimension and Bristol Index in Asian population: An MRI study |
2021 |
Annals of Medicine and Surgery |
72 |
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103072 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119336941&doi=10.1016%2fj.amsu.2021.103072&partnerID=40&md5=76f21a6d143ef68b4875caad0c2a0bc0 |
Department of Orthopaedic and Traumatology, Fatmawati General Hospital - Faculty of Medicine Universitas Indonesia, Jl. RS Fatmawati no. 4, Jakarta Selatan, 12430, Indonesia; Department of Orthopaedic and Traumatology, Dr. Cipto Mangunkusumo General Hospital – Faculty of Medicine Universitas Indonesia, Jl. Diponegoro no. 71, Jakarta Pusat, 10430, Indonesia; Department of Orthopaedic and Traumatology, Pasar Rebo General Hospital, Jl. TB Simatupang no. 30, Jakarta Timur, 13760, Indonesia; Jakarta Knee, Shoulder and Orthopaedic Sport Clinic, Pondok Indah Hospital, Jl. Metro Duta Kav UE, Jakarta, 12310, Indonesia |
Pontoh, L.A., Department of Orthopaedic and Traumatology, Fatmawati General Hospital - Faculty of Medicine Universitas Indonesia, Jl. RS Fatmawati no. 4, Jakarta Selatan, 12430, Indonesia; Dilogo, I.H., Department of Orthopaedic and Traumatology, Dr. Cipto Mangunkusumo General Hospital – Faculty of Medicine Universitas Indonesia, Jl. Diponegoro no. 71, Jakarta Pusat, 10430, Indonesia; Rahyussalim, A.J., Department of Orthopaedic and Traumatology, Dr. Cipto Mangunkusumo General Hospital – Faculty of Medicine Universitas Indonesia, Jl. Diponegoro no. 71, Jakarta Pusat, 10430, Indonesia; Widodo, W., Department of Orthopaedic and Traumatology, Dr. Cipto Mangunkusumo General Hospital – Faculty of Medicine Universitas Indonesia, Jl. Diponegoro no. 71, Jakarta Pusat, 10430, Indonesia; Pandapotan Hutapea, R.E., Department of Orthopaedic and Traumatology, Pasar Rebo General Hospital, Jl. TB Simatupang no. 30, Jakarta Timur, 13760, Indonesia; Fiolin, J., Jakarta Knee, Shoulder and Orthopaedic Sport Clinic, Pondok Indah Hospital, Jl. Metro Duta Kav UE, Jakarta, 12310, Indonesia |
Background: Restoration of patellar thickness is pivotal during a total knee arthroplasty (TKA). Several studies showed there are differences in the knee measurements between Asian and Western population. Purpose: This study aims to evaluate the patellar dimension and Bristol Index of patellar width to thickness (BIPWiT) using magnetic resonance imaging (MRI) in Asian population. Study design: This is a descriptive epidemiology study. Methods: 101 MRI scans of young adult patients with normal patellofemoral joint (PFJ) age 17–40 were evaluated from January 2019 to December 2020. Exclusion criteria included patella-femoral pathology and degenerative joint disease. Data of gender, body height and weight were obtained from physical examination, while patella height, width and thickness were obtained using MRI measurement. Descriptive analysis was used to get the mean and standard deviation of patella dimension, whereas correlation between patella thickness with patella width and length were analyzed using Pearson correlation and BIPWiT ratio was obtained by dividing the patellar width and patellar thickness. Results: Mean patellar length was 30.06 ± 2.94 (29.48–30.64); patellar width was 44.13 ± 4.44 (43.26–45.01); and patellar thickness was 23.89 ± 2.33 (23.43–24.35). Patellar dimension in male were significantly larger compared to female (P < 0.001). However, there was no difference in cartilage thickness between male and female (P = 0.305). There was strong correlation between patellar width and patellar thickness (r = 0.66; P < 0.001) with BIPWiT ratio of 1.85 ± 0.15. Conclusion: BIPWiT of 1.8:1 between patellar width and patellar thickness was recommended as a guide for patellar thickness restoration during TKA. There is no difference of patellar dimension between Asian and Western population in a healthy knee. Clinical relevance: The result of BIPWiT ratio found in this study may aid upon pre-operative planning prior TKA for surgeons in order to achieve optimal patellar thickness and avoid patellofemoral problem. What is known about the subject: Currently there are raising concerns about the different sizes of knee measurements between Asian and Western population which will affect techniques during TKA to achieve optimum result. What this study adds to the existing knowledge: This study not only prove that there is no difference between patellar dimension of Asian and Caucasian but also found a similar BIPWiT ratio for patellar resection during TKA with previous literature. Level of evidence: Level III. © 2021 The Authors |
Anthropometric; Bristol index; MRI; Patella thickness; Patella width |
adult; Article; Asian; body height; body mass; body weight; bristol index; clinical assessment; cross-sectional study; descriptive research; female; human; intrarater reliability; major clinical study; male; nuclear magnetic resonance imaging; patellar dimension; patellar thickness; patellofemoral joint; retrospective study; size; thickness; total knee arthroplasty |
Elsevier Ltd |
20490801 |
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Article |
Q3 |
391 |
12334 |
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46 |
Martika W., Dilogo I.H., Setyawan R. |
57221741247;56161962800;57206249736; |
Functional outcome in scapular fracture treatment evaluation with 2-year follow-up in Cipto Mangunkusumo Hospital |
2021 |
International Journal of Surgery Open |
37 |
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100425 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119256972&doi=10.1016%2fj.ijso.2021.100425&partnerID=40&md5=b50a45ce664d7aea0b7dc9549bdde380 |
Department of Orthopaedics and Traumatology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Adult Reconstruction, Hip, and Knee Division, Department of Orthopaedics and Traumatology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Martika, W., Department of Orthopaedics and Traumatology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Dilogo, I.H., Adult Reconstruction, Hip, and Knee Division, Department of Orthopaedics and Traumatology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setyawan, R., Department of Orthopaedics and Traumatology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Standard treatment of scapular fractures is still controversial. There was no consensus for the best indication in surgical management and therapeutic choice of the scapular fracture. This study aim is to evaluate both radiological characteristics and functional outcomes between patients with scapular fracture treated with conservative and operative management. Methods: We did a case series study of 19 patients with scapular fractures between 2012 and 2017. Nine patients were treated with open reduction internal fixation and 10 patients were treated conservatively. We evaluated radiological outcome using degree of Glenopolar Angle (GPA), angulation, and medialization through anteroposterior, lateral, and scapular Y projection, functional outcome using DASH scores, and complications in 2-year follow-up. Result: The mean patient age was 46.3 ± 18.4 years in the conservative group and 42.7 ± 11.5 years in the operative group. Fracture pattern was classified using Zdravkovic and Damholt (ZD) classification. DASH Score was excellent with 9.5 ± 2.1 points in conservative group and 6.0 ± 2.5 points in operative group with insignificant difference. There was significant difference in GPA and medialization. This is supported by functional outcome of operative group which is higher compared to conservative treatment insignificantly. Conclusion: Operative treatment resulted high functional outcome and minimal complications compared to the conservative group. Operative treatment was recommended for scapular fractures that are displaced more than 9 mm and/or angulated more than 40°. Level of evidence: II, therapeutic study. © 2021 The Authors |
Conservative treatment; DASH score; Glenopolar angle; Scapular fracture; Surgical treatment; Zdravkovic and damholt classification |
adult; clinical article; clinical outcome; conservative treatment; controlled study; Disabilities of the Arm, Shoulder and Hand (score); female; follow up; functional status; human; intermethod comparison; intraoperative period; male; open reduction (procedure); orthopedic surgery; osteosynthesis; outcome assessment; preoperative evaluation; scapula fracture; Short Survey; shoulder radiography; treatment indication; x-ray computed tomography |
Elsevier Ltd |
24058572 |
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Short Survey |
Q4 |
187 |
20224 |
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50 |
Sitorus R.S., Pambudy I.M., Rohsiswatmo R., Barliana J.D., Yulia D.E., Widyahening I.S. |
57221587271;57327482000;55533574600;57200964187;57225947931;54893154400; |
Retinal abnormalities in universal eye screening of healthy, full-term newborn infants in Jakarta. The incidence and its risk factors: a pilot study |
2021 |
International Journal of Retina and Vitreous |
7 |
1 |
67 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118713835&doi=10.1186%2fs40942-021-00337-1&partnerID=40&md5=e2db9f11d6ce04fd383ce64dbf98b9fa |
Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jalan Kimia No. 8-10, Jakarta, 10320, Indonesia; Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Sitorus, R.S., Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jalan Kimia No. 8-10, Jakarta, 10320, Indonesia; Pambudy, I.M., Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jalan Kimia No. 8-10, Jakarta, 10320, Indonesia; Rohsiswatmo, R., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Barliana, J.D., Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jalan Kimia No. 8-10, Jakarta, 10320, Indonesia; Yulia, D.E., Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jalan Kimia No. 8-10, Jakarta, 10320, Indonesia; Widyahening, I.S., Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Aim: To screen for ocular abnormalities in healthy full-term newborn infants using wide-field digital imaging and to analyze factors associated with the findings. Methods: A total of 1208 full-term newborn infants at a tertiary eye hospital (Cipto Mangunkusumo National Referral Hospital) and a district hospital in Jakarta (Koja Hospital) were enrolled to the study. All eligible newborns underwent fundus examination within 48 h after birth using the RetCam shuttle (Natus Medical Incorporated, USA). Retinal findings were documented and analyzed according to obstetric and neonatal risk factors. Results: Of the 1208 newborn infants enrolled, ocular abnormalities were found in 150 infants (12.4%). Retinal hemorrhage (RH) was the most common finding (88%) in which 2.67% involved the macula, followed by chorioretinitis (4.67%). Univariate analysis showed caesarean section (C-section) (OR 0.27, 95% CI 0.18–0.41, p < 0.001) was a protective factor against RH, while prolonged labor increased the risk of developing RH (OR 1.84, 95% CI 1.24–2.72, p = 0.002). Further multivariate analysis showed similar protective association between C-section and risk of RH (OR 0.29, 95% CI 0.19–0.44, p < 0.001), while other risk factors were not. Conclusions: Our study showed that universal eye screening in healthy neonates is beneficial in the early diagnosis, monitoring and treatment of ocular abnormalities such as retinal hemorrhage, chorioretinitis and retinoblastoma. Retinal hemorrhage is the most common ocular abnormality and is associated with the delivery method and the duration of labor. Universal eye screening is visual-saving and life-saving for neonates with chorioretinitis, retinoblastoma as well as other abnormalities and should be mandatory in newborn screening. © 2021, The Author(s). |
Delivery; Healthy newborn; Hemorrhage; Universal eye screening |
antibiotic agent; local anesthetic agent; phenylephrine; tropicamide; Article; cesarean section; chorioretinitis; coloboma; controlled study; cross-sectional study; digital imaging; early diagnosis; eye examination; female; human; incidence; intraocular tumor; macular degeneration; major clinical study; male; newborn; newborn screening; optic nerve disease; patient referral; pediatric patient; pilot study; retina disease; retina hemorrhage; retina macula hemorrhage; retina macula lutea; retina maculopathy; retinoblastoma; risk factor; vitreous hemorrhage |
BioMed Central Ltd |
20569920 |
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Q1 |
1617 |
1984 |
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54 |
Harefa, Wijaya I.P., Muhadi, Rumende C.M., Nasution S.A., Koesnoe S., Marbun M.B., Shatri H. |
57298868100;57193731572;57189615533;14325966300;57189373134;26028015000;57195201827;28767986500; |
The association between 24-h blood pressure variability and major adverse cardiac events (MACE) in hospitalized patients with acute myocardial infarction: a retrospective cohort study |
2021 |
Egyptian Heart Journal |
73 |
1 |
88 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117340121&doi=10.1186%2fs43044-021-00213-1&partnerID=40&md5=c9f1acb17b55e567ab93cb770f13356a |
Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia |
Harefa, Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia; Wijaya, I.P., Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia; Muhadi, Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia; Rumende, C.M., Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia; Nasution, S.A., Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia; Koesnoe, S., Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia; Marbun, M.B., Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia; Shatri, H., Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia |
Background: Acute myocardial infarction (AMI) is major cardiovascular disease that causes high morbidity and mortality. In AMI, ischemia and necrosis affected some cardiomyocytes leading to a decrease in myocardial contractility which is followed by an acute proinflammation reaction and increased sympathetic tone. Meanwhile, high blood pressure variability (BPV) causing an increased left ventricular workload, heart rate, myocardial oxygen demand and induces proinflamations and endothelial dysfunction. Therefore a high BPV and its associated pathological effects are likely to aggravate the physiological function of the heart and affect the emergence of acute cardiac complications in AMI patients. This study aims to investigate the association’s between short-term BPV and major adverse cardiac events (MACE) in AMI patients. This retrospective cohort study used simple random sampling to identify AMI patients who were hospitalized at Cipto Mangunkusumo National Hospital between January 2018 and December 2019. Mann Withney was performed to investigate the association between BPV and MACE. Results: The average systolic BPV value which was calculated as standard deviation (SD) and average real variability (ARV) was higher in the MACE group than in the non-MACE group. Systolic SD and systolic ARV in the MACE group were 13.28 ± 5.41 mmHg and 9.88 ± 3.81 mmHg respectively. In the non-MACE group, systolic SD and systolic ARV were 10.76 (4.59–26.17) mmHg and 8.65 (3.22–19.35) mmHg respectively. There was no significant association between BPV and MACE. However, there were significant differences between systolic SD and systolic ARV in patients with hypertension who experienced MACE and patients without hypertension who experienced MACE. Conclusions: The BPV of AMI patients who experience MACE was higher than that of non-MACE AMI patients. There was no significant association between BPV ​​and MACE during the acute phase of AMI. © 2021, The Author(s). |
Acute myocardial infarction; Average real variability; Blood pressure variability; Major adverse cardiac events |
acute heart infarction; adult; aged; Article; blood pressure monitoring; blood pressure variability; cohort analysis; controlled study; diastolic blood pressure; female; heart function; hospital patient; human; hypertension; major adverse cardiac event; major clinical study; male; retrospective study; systolic blood pressure |
Springer Science and Business Media Deutschland GmbH |
11102608 |
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Article |
Q3 |
212 |
18617 |
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58 |
Nugraha R.R., Miranda A.V., Ahmadi A., Lucero-Prisno D.E., III |
57264816700;57222664687;57219362523;56051373800; |
Accelerating Indonesian COVID-19 vaccination rollout: a critical task amid the second wave |
2021 |
Tropical Medicine and Health |
49 |
1 |
76 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115262837&doi=10.1186%2fs41182-021-00367-3&partnerID=40&md5=4ba56c15796323e2ec17398a40768955 |
USAID Health Financing Activity/ThinkWell, Jakarta, Indonesia; Faculty of Medicine, University of Indonesia, Depok, West Java, Indonesia; Medical Research Center, Kateb University, Kabul, Afghanistan; Department of Public Health, International School of Medicine, Bishkek, Kyrgyzstan; Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, United Kingdom; Faculty of Management and Development Studies, University of the Philippines (Open University), Los Baños, Laguna, Philippines |
Nugraha, R.R., USAID Health Financing Activity/ThinkWell, Jakarta, Indonesia; Miranda, A.V., Faculty of Medicine, University of Indonesia, Depok, West Java, Indonesia; Ahmadi, A., Medical Research Center, Kateb University, Kabul, Afghanistan, Department of Public Health, International School of Medicine, Bishkek, Kyrgyzstan; Lucero-Prisno, D.E., III, Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, United Kingdom, Faculty of Management and Development Studies, University of the Philippines (Open University), Los Baños, Laguna, Philippines |
Coronavirus disease-19 (COVID-19) has been spreading in every part of the world, putting nations at risk with its pandemic status, including Indonesia. COVID-19 vaccine has been deemed as one of the most effective interventions to date for mitigating the spread and mortality from COVID-19. Responding to the situation, the Government of Indonesia (GOI) has allocated the means necessary to procure and distribute COVID-19 vaccines; placing into consideration the unique context of the country, recently categorized as a middle-income country and archipelagic with a population over 270 million. This article aims to present the challenges associated with the distribution of COVID-19 vaccination as well as recommendations to mitigate them, to ensure a timely and effective COVID-19 vaccination program in Indonesia. © 2021, The Author(s). |
COVID-19; Indonesia; Pandemic; Recommendations; Second wave; Vaccination |
SARS-CoV-2 vaccine; anti-vaccination movement; coronavirus disease 2019; cryopreservation; decentralization; diplomacy; drug shortage; drug storage; funding; government; human; Indonesia; Letter; pandemic; social responsibility; vaccination; vaccination coverage; vaccine production |
BioMed Central Ltd |
13488945 |
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Letter |
Q2 |
830 |
5753 |
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59 |
Adriansyah I.A., Afriansyah A., Siregar M.A.R., Purnomo N., Mirza H., Seno D.H. |
57255172900;57190688768;57255058200;57255293100;57208513330;57255640300; |
Efficacy of holmium laser enucleation of the prostate in patients with detrusor underactivity: systematic review and meta-analysis |
2021 |
African Journal of Urology |
27 |
1 |
128 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114753119&doi=10.1186%2fs12301-021-00230-1&partnerID=40&md5=a5780c3ae26d7da14412977dd81e01f7 |
Department of Urology, Faculty of Medicine, Universitas Indonesia, Jl. Diponegoro No. 71, Salemba, Jakarta Pusat, Jakarta, DKI Jakarta 10430, Indonesia; Division of Urology, Department of Surgery, Persahabatan Hospital, Jl. Persahabatan Raya No. 1, Pulo Gadung, Jakarta Timur, Jakarta, DKI Jakarta 13230, Indonesia |
Adriansyah, I.A., Department of Urology, Faculty of Medicine, Universitas Indonesia, Jl. Diponegoro No. 71, Salemba, Jakarta Pusat, Jakarta, DKI Jakarta 10430, Indonesia; Afriansyah, A., Division of Urology, Department of Surgery, Persahabatan Hospital, Jl. Persahabatan Raya No. 1, Pulo Gadung, Jakarta Timur, Jakarta, DKI Jakarta 13230, Indonesia; Siregar, M.A.R., Division of Urology, Department of Surgery, Persahabatan Hospital, Jl. Persahabatan Raya No. 1, Pulo Gadung, Jakarta Timur, Jakarta, DKI Jakarta 13230, Indonesia; Purnomo, N., Division of Urology, Department of Surgery, Persahabatan Hospital, Jl. Persahabatan Raya No. 1, Pulo Gadung, Jakarta Timur, Jakarta, DKI Jakarta 13230, Indonesia; Mirza, H., Division of Urology, Department of Surgery, Persahabatan Hospital, Jl. Persahabatan Raya No. 1, Pulo Gadung, Jakarta Timur, Jakarta, DKI Jakarta 13230, Indonesia; Seno, D.H., Division of Urology, Department of Surgery, Persahabatan Hospital, Jl. Persahabatan Raya No. 1, Pulo Gadung, Jakarta Timur, Jakarta, DKI Jakarta 13230, Indonesia |
Background: Benign prostatic hyperplasia (BPH) is commonly found in the aging male. Treatment of BPH can be in form of conservative or surgical intervention. Transurethral resection of the prostate (TURP) is the gold-standard treatment for BPH according to the guideline. However, there is no evidence that there is a benefit for TURP in patients with detrusor underactivity (DUA). Holmium laser enucleation (HoLEP) is theorized to have a better outcome due to its property of complete prostate enucleation. Therefore, this meta-analysis aims to determine the benefit of HoLEP for BPH patients with DUA. Main body: We performed systematic literature searching from five databases including PubMed, Scopus, Embase, Science Direct, and Web of Science for articles up to 31 December 2020 for relevant studies. A total of five articles are eligible for this meta-analysis. A total of 2.180 subjects participated in all of the studies included. Two studies comparing patients with and without DUA that was treated with HoLEP, two studies comparing HoLEP with other surgical approaches for BPH, and one study comparing both parameters. IPSS score reduction is significantly higher in the patients with DUA (Mean Difference = 3.28, 95% CI 1.91 to 4.64, p < 0.01). Qmax and PVR are not significantly different between both groups. HoLEP also showed better improvement in IPSS and Qmax compared to TURP (IPSS: Mean Difference = -4.80, 95% CI − 7.83 to − 1.77, p = 0.002; Qmax: Mean Difference = 4.20, 95% CI 0.58 to 7.82, p = 0.02) and PVP (IPSS: Mean Difference = − 2.47, 95% CI − 4.47 to − 0.47, p = 0.02; Qmax: Mean Difference = 2.31, 95% CI 0.34 to 4.28, p = 0.02). Conclusion: HoLEP showed better improvement in IPSS scores in patients with DUA. HoLEP can be considered to be performed in the BPH patients with DUA for better outcomes for the patients. © 2021, The Author(s). |
Benign prostatic hyperplasia; Detrusor underactivity; HoLEP; Laser enucleation; Surgical outcome |
clinical effectiveness; Embase; enucleation; human; hypotonic bladder; information retrieval; intermethod comparison; International Prostate Symptom Score; laser surgery; male; measurement; Medline; meta analysis; Newcastle-Ottawa scale; postvoid residual urine volume; prostate hypertrophy; prostate surgery; randomized controlled trial (topic); Review; ScienceDirect; Scopus; surgical approach; systematic review; transurethral resection; Web of Science |
Springer Science and Business Media Deutschland GmbH |
11105704 |
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Review |
Q4 |
174 |
21103 |
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