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Rahmat B., Dwita N.U., Arya Wardana P.W., Lilyasari O. |
57192273755;57402910300;57403605200;57192914838; |
Preoperative Left Ventricle End Diastolic Volume Index as a Predictor for Low Cardiac Output Syndrome After Surgical Closure of Secundum Atrial Septal Defect With Small-Sized Left Ventricle |
2021 |
Frontiers in Pediatrics |
9 |
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705257 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122447256&doi=10.3389%2ffped.2021.705257&partnerID=40&md5=6da645c8d6ae19fd8dfd4e9dc9a05bcb |
Pediatric and Congenital Heart Surgery Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Centre Harapan Kita, Jakarta, Indonesia |
Rahmat, B., Pediatric and Congenital Heart Surgery Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Dwita, N.U., Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Arya Wardana, P.W., Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Lilyasari, O., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Centre Harapan Kita, Jakarta, Indonesia |
Introduction: Low cardiac output syndrome is one of the postoperative complications that are associated with significant morbidity and mortality after surgical closure of atrial septal defect (ASD) with small-sized left ventricle (LV). This study investigated whether preoperative left ventricular end-diastolic volume index (LVEDVi) could accurately predict low cardiac output syndrome (LCOS) after surgical closure of ASD with small-sized LV. Method: This retrospective cohort study involved adult ASD patients with small-sized LV from January 2018 to December 2019 in National Cardiovascular Center Harapan Kita. Preoperative MRI data to assess the left and right ventricle volume were collected. A bivariate analysis using independent Student's t-test was done. Diagnostic test using receiver operating characteristic (ROC) curve was also done to obtain the area under the curve (AUC) value. The best cutoff point was determined by Youden's index. Result: Fifty-seven subjects were involved in this study [age (mean ± SD) 32.56 ± 13.15 years; weight (mean ± SD) 48.82 ± 12.15 kg]. Subjects who had post-operative LCOS (n = 30) have significantly lower LVEDVi (45.0 ± 7.42 ml/m2 vs. 64.15 ± 13.37 ml/m2; p < 0.001), LVEDV (64.6 ± 16.0 ml vs. 85.9 ± 20.7 ml; p < 0.001), LVSV (38.97 ± 11.5 ml vs. 53.13 ± 7.5 ml; p < 0.001), and LVSVi (27.28 ± 8.55 ml/m2 vs. 37.42 ± 5.35 ml/m2; p < 0.001) compared to subjects who did not have post-operative LCOS (n = 27). ROC analysis showed that the best AUC was found on LVEDVi (AUC 95.3%; 95% confidence interval: 90.6–100%). The best cutoff value for LVEDVi to predict the occurrence of LCOS after surgical closure of ASD was 53.3 ml/m2 with a sensitivity of 86.7% and a specificity of 85.2%. Conclusion: This study showed that preoperative LVEDVi could predict LCOS after surgical closure of ASD with small-sized LV with a well-defined cutoff. The best cutoff value of LVEDVi to predict the occurrence of LCOS after surgical ASD closure was 53.5 ml/m2. Copyright © 2021 Rahmat, Dwita, Arya Wardana and Lilyasari. |
ASD closure; atrial septal defect; left ventricle end diastolic volume; low cardiac output syndrome; magnetic resonance imaging (MRI) |
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Frontiers Media S.A. |
22962360 |
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Article |
Q1 |
960 |
4641 |
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6 |
Pranata R., Huang I., Lim M.A., Yonas E., Vania R., Lukito A.A., Nasution S.A., Siswanto B.B., Kuswardhani R.A.T. |
57201973901;57208576645;57216039756;57201987097;57208328436;57213835420;57189373134;14422648800;36863900500; |
Elevated De Ritis Ratio Is Associated With Poor Prognosis in COVID-19: A Systematic Review and Meta-Analysis |
2021 |
Frontiers in Medicine |
8 |
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676581 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122327729&doi=10.3389%2ffmed.2021.676581&partnerID=40&md5=254957cc5c17b448a803a88e33741d8f |
Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Faculty of Medicine, Department of Internal Medicine, Hasan Sadikin General Hospital, Universitas Padjadjaran, Bandung, Indonesia; Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Faculty of Medicine, Division of Plastic, Reconstructive, and Aesthetic, Department of Surgery, Sanglah General Hospital, Udayana University, Jimbaran, Indonesia; Department of Cardiology and Vascular Medicine, Siloam Hospitals Lippo Village, Tangerang, Indonesia; Faculty of Medicine, Division of Cardiology, Department of Internal Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Faculty of Medicine, Department of Cardiology and Vascular Medicine, National Cardiovascular Center Harapan Kita, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Division of Geriatrics, Department of Internal Medicine, Sanglah Teaching Hospital, Udayana University, Denpasar, Indonesia |
Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Huang, I., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Faculty of Medicine, Department of Internal Medicine, Hasan Sadikin General Hospital, Universitas Padjadjaran, Bandung, Indonesia; Lim, M.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Yonas, E., Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Vania, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Faculty of Medicine, Division of Plastic, Reconstructive, and Aesthetic, Department of Surgery, Sanglah General Hospital, Udayana University, Jimbaran, Indonesia; Lukito, A.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Department of Cardiology and Vascular Medicine, Siloam Hospitals Lippo Village, Tangerang, Indonesia; Nasution, S.A., Faculty of Medicine, Division of Cardiology, Department of Internal Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Siswanto, B.B., Faculty of Medicine, Department of Cardiology and Vascular Medicine, National Cardiovascular Center Harapan Kita, Universitas Indonesia, Jakarta, Indonesia; Kuswardhani, R.A.T., Faculty of Medicine, Division of Geriatrics, Department of Internal Medicine, Sanglah Teaching Hospital, Udayana University, Denpasar, Indonesia |
Objective: This meta-analysis aims to assess whether elevated De Ritis ratio is associated with poor prognosis in patients with coronavirus 2019 (COVID-19). Methods: A systematic literature search was performed using PubMed, Embase, and EuropePMC databases up until September 17, 2021. De Ritis ratio is also known as Aspartate aminotransferase/alanine transaminase (AST/ALT) ratio. The main outcome was poor prognosis, a composite of mortality, severity, the need for ICU care, and intubation. The effect measure was odds ratios (ORs) and mean differences. We generated sensitivity and specificity, negative and positive likelihood ratio (NLR and PLR), diagnostic odds ratio (DOR), and area under curve (AUC). Results: There were eight studies with 4,606 patients. De Ritis ratio was elevated in 44% of the patients. Patients with poor prognosis have higher De Ritis ratio [mean difference 0.41 (0.31, 0.50), p < 0.001; I2: 81.0%] and subgroup analysis showed that non-survivors also have higher De Ritis Ratio [mean difference 0.47 (0.46, 0.48), p < 0.001; I2: 0%]. Elevated De Ritis ratio was associated with poor prognosis [OR 3.28 (2.39, 4.52), p < 0.001; I2: 35.8%]. It has a sensitivity of 55% (36–73), specificity of 71% (52–85), PLR 1.9, NLR.63, DOR of 3 (2–4), and AUC of.67 (0.63–0.71). The posterior probability of poor prognosis was 38% if De Ritis is elevated, while 17% if De Ritis is not elevated. Conclusion: Elevated De Ritis ratio is associated with poor prognosis in patients with COVID-19. Systematic Review Registration: PROSPERO ID: CRD42020216634. Copyright © 2021 Pranata, Huang, Lim, Yonas, Vania, Lukito, Nasution, Siswanto and Kuswardhani. |
coronavirus—COVID-19; De Ritis ratio; liver enzyme; SARS-CoV-2; transaminase |
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Frontiers Media S.A. |
2296858X |
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Review |
Q1 |
1388 |
2608 |
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8 |
Sartika D., Nurrachmah E., Sukirman D.I., Mansyur M., Supartono B. |
57467276300;57466703100;57467568600;37085506800;57205286040; |
Ergonomic Risk-prone Activities toward Nurses in the Intensive Care and Emergency Room |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
T5 |
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48 |
53 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125269929&doi=10.3889%2fOAMJMS.2021.7851&partnerID=40&md5=e4f606505a7f1d2f7fa6498e532fb934 |
Health Polytechnic of Riau, Pekanbaru, Indonesia; Department of Medical Surgery, Faculty of Nursing, University of Indonesia, Jakarta, Indonesia; Department of Basic Science and Fundamentals of Nursing, Faculty of Nursing, University of Indonesia, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Faculty of Medicine, Pembangunan Nasional University, Jakarta, Indonesia |
Sartika, D., Health Polytechnic of Riau, Pekanbaru, Indonesia; Nurrachmah, E., Department of Medical Surgery, Faculty of Nursing, University of Indonesia, Jakarta, Indonesia; Sukirman, D.I., Department of Basic Science and Fundamentals of Nursing, Faculty of Nursing, University of Indonesia, Jakarta, Indonesia; Mansyur, M., Department of Community Medicine, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Supartono, B., Faculty of Medicine, Pembangunan Nasional University, Jakarta, Indonesia |
BACKGROUND: Nurses have the risk of ergonomic hazards in providing nursing care, especially with increasingly dynamic health services such as during Coronavirus disease-19 pandemic like today. AIM: The aim of the study was to evaluate activities prone to produce ergonomic risks during the implementation of nursing care in intensive care and emergency room (ER) of a hospital in Riau, Indonesia. METHODOLOGY: This study was conducted by observing the routine activities conducted by the nurses and using similar task group techniques equipped with Rapid Entire Body Assessment instrument. Those observed activities were obtained from 17 intensive care room nurses and ten ER nurses. There were six activities observed in the intensive care room: Bathing, transferring the patient, wounds dressing, taking blood samples for the AGDA examinations, as well as inserting the intravenous needle and electrocardiograms. Meanwhile, there were two activities observed in the ER: Transferring the patient and inserting the intravenous needle. RESULTS: The highest ergonomic risks activity in the intensive care room was bathing the patient with a total score of 13. At the ER, the highest risk score was transferring the patient with a total score of 12. Both activities were at level 4, indicating a high-risk condition. Thus, examinations and changes should be immediately initiated. CONCLUSION: The results are significant to be paid attention by the related parties at the hospital to facilitate some improvements immediately. In addition, the ergonomic approaches that can be suggested to the nurses are regular stretching, physical exercises, and applying ergonomic principles while working. © 2021 Dewi Sartika, Elly Nurrachmah, Dewi Irawaty Sukirman, Muchtaruddin Mansyur, Basuki Supartono. |
Emergency room; Ergonomic risk; Intensive care; Nurse’s activity; Nursing intervention |
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Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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10 |
Lee Y.-S., Oh Y.S., Choi E.-K., Chern A.K.C., Jiampo P., Chutinet A., Hanafy D.A., Trivedi P., Zhai D. |
57369401600;14021940000;35558194200;57219941181;57219936937;15724336700;55431326800;57219936294;57219941292; |
Patient perception and treatment convenience of dabigatran versus vitamin K antagonist when used for stroke prophylaxis in atrial fibrillation: Real-world Evaluation of Long-term Anticoagulant Treatment Experience (RE-LATE) study |
2021 |
Open Heart |
8 |
2 |
e001745 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121029837&doi=10.1136%2fopenhrt-2021-001745&partnerID=40&md5=604033aab18ff9417453572cb72e2905 |
Department of Internal Medicine, Daegu Catholic University College of Medicine, Daegu, South Korea; Department of Internal Medicine, Catholic University of Korea, Seoul, South Korea; Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea; Department of Cardiology, Columbia Asia Hospital, Taiping, Malaysia; Department of Medicine, Bhumibol Adulyadej Hospital, Bangkok, Thailand; Chulalongkorn Stroke Center, King Chulalongkorn Memorial Hospital, Bangkok, Thailand; Division of Neurology, Department of Medicine, Chulalongkorn University, Bangkok, Thailand; Cardiology and Vascular Medicine, Pusat Jantung Nasional Harapan Kita, Jakarta, Indonesia; Cardiology and Vascular Medicine, University of Indonesia Faculty of Medicine, Jakarta, Indonesia; Boehringer Ingelheim Singapore Pte Ltd, Singapore, Singapore; Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT, United States |
Lee, Y.-S., Department of Internal Medicine, Daegu Catholic University College of Medicine, Daegu, South Korea; Oh, Y.S., Department of Internal Medicine, Catholic University of Korea, Seoul, South Korea; Choi, E.-K., Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea; Chern, A.K.C., Department of Cardiology, Columbia Asia Hospital, Taiping, Malaysia; Jiampo, P., Department of Medicine, Bhumibol Adulyadej Hospital, Bangkok, Thailand; Chutinet, A., Chulalongkorn Stroke Center, King Chulalongkorn Memorial Hospital, Bangkok, Thailand, Division of Neurology, Department of Medicine, Chulalongkorn University, Bangkok, Thailand; Hanafy, D.A., Cardiology and Vascular Medicine, Pusat Jantung Nasional Harapan Kita, Jakarta, Indonesia, Cardiology and Vascular Medicine, University of Indonesia Faculty of Medicine, Jakarta, Indonesia; Trivedi, P., Boehringer Ingelheim Singapore Pte Ltd, Singapore, Singapore; Zhai, D., Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT, United States |
Purpose Dabigatran is a direct thrombin inhibitor approved for stroke prophylaxis in patients with non-valvular atrial fibrillation (NVAF). Real-world data about patient preference, satisfaction and convenience in patients in Asia are not available. The study aimed to explore the perception of patients with newly diagnosed NVAF regarding dabigatran versus vitamin K antagonists (VKAs), when used for stroke prevention. Patients and methods This was a multinational, multicentre, non-interventional study involving 49 sites across 5 countries in South East Asia and South Korea where 934 patients newly diagnosed with NVAF were initiated on either dabigatran (N=591) or VKA (N=343). Data were collected at baseline and over two follow-up visits across 6 months. Treatment satisfaction and patient convenience were evaluated using the Perception on Anticoagulant Treatment Questionnaire-2 (PACT-Q2). Results The mean age of the patients was 65.9±10.4 years, and 64.2% were male. Mean CHA 2 DS 2-VASc score was 2.4±1.5, and mean HAS-BLED score was 1.2±0.9. At baseline, patients initiated on dabigatran had higher stroke risk, bleeding risk, creatinine clearance and proportion of patients with concomitant illnesses compared with patients initiated on VKAs. Treatment convenience was perceived to be significantly better with dabigatran versus VKAs at visits 2 and 3 (p=0.0423 and 0.0287, respectively). Treatment satisfaction was significantly better with dabigatran compared with VKAs at visit 3 (p=0.0300). Conclusion In this study, dabigatran is associated with better patient perception in terms of treatment convenience and satisfaction compared with VKAs when used for stroke prevention in newly diagnosed NVAF patients from South East Asia and South Korea. Plain language summary Patient satisfaction with dabigatran versus VKAs in South East Asia. Patients with atrial fibrillation are at high risk of stroke and require anticoagulants for stroke prevention. Two such anticoagulants are dabigatran and VKAs. We wanted to compare the extent of satisfaction and treatment convenience among newly diagnosed patients with atrial fibrillation from the South East Asian region when they were given either dabigatran or VKAs. Consenting patients filled out a standardised questionnaire called the PACT-Q2 over three visits after they were started on either dabigatran (591 patients) or VKAs (343 patients). We found that satisfaction and convenience were significantly higher when patients received dabigatran than when they received VKAs. © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
Atrial fibrillation; Health care; Outcome assessment; Stroke |
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BMJ Publishing Group |
2398595X |
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Article |
Q1 |
1050 |
4080 |
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11 |
Tenda E.D., Asaf M.M., Pradipta A., Kumaheri M.A., Susanto A.P. |
57189692101;57216406843;57216644806;56460248100;57221504275; |
The COVID-19 surge in Indonesia: what we learned and what to expect |
2021 |
Breathe |
17 |
4 |
210146 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125813131&doi=10.1183%2f20734735.0146-2021&partnerID=40&md5=e838dc0478f791b7743b4f42a51b2464 |
Division of Respirology and Critical Illness, Dept of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Genomik Solidaritas Indonesia (GSI) Lab, Jakarta, Indonesia |
Tenda, E.D., Division of Respirology and Critical Illness, Dept of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Asaf, M.M., Division of Respirology and Critical Illness, Dept of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Pradipta, A., Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Genomik Solidaritas Indonesia (GSI) Lab, Jakarta, Indonesia; Kumaheri, M.A., Genomik Solidaritas Indonesia (GSI) Lab, Jakarta, Indonesia; Susanto, A.P., Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Genomik Solidaritas Indonesia (GSI) Lab, Jakarta, Indonesia |
[No abstract available] |
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European Respiratory Society |
18106838 |
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Editorial |
Q2 |
677 |
7384 |
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12 |
Ramlan A.A.W., Mahri I., Firdaus R., Sugiarto A. |
57195941841;57459772200;57188923555;57189612291; |
Comparison of Efficacy of Premedication between Dexmedetomidine and Midazolam Intranasal for the Prevention of Emergence Delirium in Children Undergoing Ophthalmic Surgery |
2021 |
Turkish Journal of Anaesthesiology and Reanimation |
49 |
6 |
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439 |
444 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85124935387&doi=10.5152%2fTJAR.2021.1305&partnerID=40&md5=bd1c40a8ff29473a6db3aa32aacb92ad |
Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Ramlan, A.A.W., Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mahri, I., Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Firdaus, R., Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sugiarto, A., Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Objective: Emergence delirium (ED) is a condition that can occur when a child recovers from anaesthesia uncomfortably. ED can potentially injure children and indirectly discomforts parents. Various interventions were carried out to reduce ED, but there is no specific standard that has been established to prevent ED. Dexmedetomidine and midazolam are said to be effective in reducing ED. This study aims to determine the effectiveness of intranasal dexmedetomidine premedication compared to intranasal midazolam to prevent ED in children undergoing eye surgery. Methods: This study was a double-blinded randomised clinical trial. Paediatric patients aged 1-12 years with physical status ASA 1 and 2 who underwent eye surgery under general anaesthesia using sevoflurane inhalation were included in the study. There were 64 children obtained by consecutive sampling who underwent eye surgery in our institution between February and May 2019. The subjects were then randomised into the dexmedetomidine group and the midazolam group. Effectiveness was assessed from ED events, recovery time and post-premedication desaturation events. Data analysis was performed using Chi-square test and Mann–Whitney test. Results: ED incidence in the dexmedetomidine group was 11.18% compared to 28.12% in the midazolam group (P = .109). The recovery time was found to be at a median of 6 minutes for both groups, and no desaturation was found in either group. Conclusion: There is statistically no significant difference between the effectiveness of intranasal dexmedetomidine and midazolam premedication 30 minutes before induction to prevent ED occurrence in children undergoing eye surgery. © 2021 by Turkish Society of Anaesthesiology and Reanimation. |
Delirium; Dexmedetomidine; Emergence; Eye surgery; Midazolam |
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AVES |
2667677X |
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Article |
Q3 |
322 |
14155 |
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19 |
Tantri A.R., Sukmono R.B., Atmadja L.S. |
57188933853;57204643526;57422197300; |
Comparison of recovery time with target controlled infusion of propofol with sevoflurane anesthesia using bispectral index monitoring in vitrectomy surgery |
2021 |
Anaesthesia, Pain and Intensive Care |
25 |
6 |
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707 |
712 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123272271&doi=10.35975%2fapic.v25i6.1689&partnerID=40&md5=a8e07d9abeb4fd0d01a1bb03c52954f1 |
Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Pangeran Diponegoro Street No. 71, Kenari, Senen, DKI Jakarta, Central Jakarta, 10430, Indonesia |
Tantri, A.R., Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Pangeran Diponegoro Street No. 71, Kenari, Senen, DKI Jakarta, Central Jakarta, 10430, Indonesia; Sukmono, R.B., Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Pangeran Diponegoro Street No. 71, Kenari, Senen, DKI Jakarta, Central Jakarta, 10430, Indonesia; Atmadja, L.S., Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Pangeran Diponegoro Street No. 71, Kenari, Senen, DKI Jakarta, Central Jakarta, 10430, Indonesia |
Background: Rapid recovery after anesthesia is critical and is associated with the anesthetic agents used. The bispectral index (BIS) monitoring to guide anesthetic agents' doses may play a significant role in the recovery time. This study compared recovery time after Target Controlled Infusion (TCI) of propofol with sevoflurane anesthesia by using BIS monitoring during vitrectomy surgery. Methodology: This was a prospective observational, randomized study on 40 patients aged 18-65 y, physical status ASA I-II, body mass index (BMI) 18-30 kg/m2, who underwent vitrectomy surgery. Subjects were randomly assigned into two groups, Group P - the TCI propofol group, and Group S - the sevoflurane group. Subjects in the Group P received TCI propofol (Schnider), and subjects in the Group S received sevoflurane for anesthesia maintenance, with a targeted BIS score of 40-60. Inj. fentanyl 1 μg/kg was administered if there was an increase in blood pressure, heart rate and/or BIS that could not be overcome by increasing the dose of TCI propofol or sevoflurane. Recovery time was calculated from when the maintenance regimen was stopped until the patient was able to obey simple commands. Recovery time, fentanyl consumption, postoperative agitation, nausea and vomiting incidence were noted and analyzed with SPSS v21.0 for Windows. T-Test or Mann-Whitney U test was performed to analyze the data. Result: Recovery time in the Group P [11.5 (5-25) min)] was not significantly different from the Group S [9 (4-18) min, p = 0.139]. Total fentanyl consumption was higher in the Group P than in the Group S (1.765 vs. 1.428 μg/kg). The frequency of agitation during recovery was higher in the Group S than in the Group P (30% vs. 20%) Conclusion: There was no significant difference in recovery time between TCI propofol and sevoflurane anesthesia using BIS monitoring in vitrectomy. Total fentanyl consumption was higher in the propofol group than in the sevoflurane group. The impact of these anesthetic regimens on postoperative agitation needs further investigation. © 2021 Faculty of Anaesthesia, Pain and Intensive Care, AFMS. All rights reserved. |
BIS; Bispectral index monitoring; Intravenous anesthesia; Propofol; Sevoflurane; Target Controlled Infusion; TCI; Vitrectomy |
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Faculty of Anaesthesia, Pain and Intensive Care, AFMS |
16078322 |
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Article |
Q3 |
170 |
21404 |
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20 |
Kartika R.W., Alwi I., Yunir E., Waspadji S., Bardosono S., Immanuel S., Silalahi T., Sungkar S., Rachmat J., Suyatna F.D., Reksodiputro M.H. |
57223447932;15055173800;36520254800;8678136400;21933841000;57272979000;56275255400;57016857300;6507225348;56039633100;35090488800; |
A new innovation in topical diabetic foot ulcer; hyaluronic acid platelet-rich fibrin (HAPRF) gel - a study in inflammation and angiogenesis |
2021 |
Bali Medical Journal |
10 |
3 |
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901 |
908 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123104761&doi=10.15562%2fbmj.v10i3.2317&partnerID=40&md5=60a98c7a6392eaa4cf35d6bc5c895812 |
Medical Science Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Internal Medicine, Krida Wacana Christian University, Jakarta, Indonesia; Department of Clinical Parasitology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Thoracic Cardiac and Vascular Surgery, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Clinical Pharmacology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Departement Facial Plastic Reconstructive Division, Department of Otorhinolaryngology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Kartika, R.W., Medical Science Faculty of Medicine, Universitas Indonesia, Indonesia; Alwi, I., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Yunir, E., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Waspadji, S., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Immanuel, S., Department of Clinical Pathology, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Silalahi, T., Department of Internal Medicine, Krida Wacana Christian University, Jakarta, Indonesia; Sungkar, S., Department of Clinical Parasitology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rachmat, J., Department of Thoracic Cardiac and Vascular Surgery, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Suyatna, F.D., Department of Clinical Pharmacology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Reksodiputro, M.H., Departement Facial Plastic Reconstructive Division, Department of Otorhinolaryngology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Background: Indonesia ranks 6th out of ten countries with the highest number of diabetes patients. An increase followed this condition in the prevalence of diabetic foot ulcers by around 15%. This study demonstrated the ability of combination of Platelet Rich Fibrin (PRF) and Hyaluronic Acid (HA) to reduce inflammation in diabetic foot ulcer (DFU) healing. Methods: In the baseline, all patients received the same treatment including wound debridement. There were 20 subjects divided into two groups; HAPRF and PRF. A part of sample was processed into lysate and stored in -80oC. The rest is applied as a topical therapy in DFU base on intervention. We analyzed the inflammation using two methods; swab in DFU and fibrin gel of HAPRF or PRF and ELISA on day-3 and day-7. We also measure the granulation index by digital photograph and analyze use ImageJ at the same time. Result: There were 20 diabetic patients with DFUs, performed analysis of IL-6 lysate gel HAPRF decrease significantly compare with PRF on day 3 (p= 0.038) and day-7 (p = 0.034). Granulation index evaluation, in HAPRF increase on day-3 (p = 0.043), day-7 (p = 0.049), and day-14 (p = 0.041). Conclusion: A-PRF +HA administration leads to reduce IL-6 levels, and accelerated wound healing of DFUs patients. HAPRF directly aids epithelialization and granulation index. © 2021, Sanglah General Hospital. All rights reserved. |
Diabetic foot ulcer; Fibrin; Granulation index; Hyaluronic acid; Inflammation; Platelet |
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Sanglah General Hospital |
20891180 |
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Hakim R.W., Fadilah F., Tarigan T.J.E., Jusman S.W.A., Purwaningsih E.H. |
57195939974;56966708600;36057746500;36518792100;57186723500; |
Molecular Study of Acalypha indica to Leptin, Alpha Glucosidase, and its Antihyperglycemic Effect on Alpha Glucosidase |
2021 |
Pharmacognosy Journal |
13 |
6 |
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1639 |
1647 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123002540&doi=10.5530%2fpj.2021.13.211&partnerID=40&md5=fc96d1ad7798feb0ce298321c8f24117 |
Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Drug Development and Research Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia; Bioinformatics Core Facilities, The Indonesian Medical Education and Research Institute, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia |
Hakim, R.W., Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Drug Development and Research Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia; Fadilah, F., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Drug Development and Research Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia, Bioinformatics Core Facilities, The Indonesian Medical Education and Research Institute, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia; Tarigan, T.J.E., Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Jusman, S.W.A., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Purwaningsih, E.H., Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Drug Development and Research Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia |
Introduction: The purpose of this study is to find potential inhibitors of leptin as a proinflammatory adipokine and alpha glucosidase as an enzyme that mediate hyperglycaemia; to alter the chronic complications of obesity from herbal Acalypha indica (Ai). This study was conducted using in silico molecular docking to evaluate the Ai compounds interaction with leptin and alpha glucosidase. The in vitro assay to alpha glucosidase was done to explore antihyperglycemic effect of Ai, as hyperglycaemia is the key process of chronic complication of obesity. Material and Methods: Protein target were leptin and alpha glucosidase; compounds from Ai plant were repundusinic, mauritanin, hesperetin, acaindinin, and glucogalin in pdb format. Molecular docking using autodock vinna. In vitro assay of Ai antihyperglycemic activity was done to alpha glucosidase and was define as IC50 level. Result: The results from the docking analysis demonstrated that compounds from Ai roots contain antihyperglycemic-antiobesity activity which acted by inhibiting leptin and alpha glucosidase receptors. Repundusininc and mauritanin compounds contain hydrogen bond with the greatest leptin enhancer activity on Ser9, Thr35, Glu8, Ser9, Thr25, Gln111, Lys211, Leu7 for repundisinic and Glu8, Thr25, Gly112 and Leu7 for mauritanin. Hesperetin, acaindinin and glucogallin were the most identical compounds with similar affinity binding value to alpha glucosidase. Ai roots was already proven as anti-hyperglycemic-antiobesity which was further confirmed by in vitro assay to alpha glucosidase (IC50 19,429 μg/ml.). Conclusion: The results demonstrated that Ai have anti hyperglycaemic-antiobesity effects and was found to be potentially as antihyperglycemic by in vitro assay to alpha glucosidase. © 2021 Phcogj.Com. |
Acalypha indica; Alpha glucosidase; Antiobesity; Leptin |
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EManuscript Technologies |
09753575 |
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Article |
Q3 |
268 |
15961 |
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23 |
Pratiwi R.Y., Elya B., Setiawan H., Solawati A., Rosmalena |
57416375400;14014224500;55292870100;57415864600;56891769500; |
Alterations in Body Weight, Blood Glucose Levels, and Lipid Profiles in High-Fat Diet-Low Dose Streptozotocin-Induced Diabetic Rats |
2021 |
Pharmacognosy Journal |
13 |
6 |
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1562 |
1567 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122997406&doi=10.5530%2fpj.2021.13.199&partnerID=40&md5=81ed302e467e0f8fcf593bb03fe63dd1 |
Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Faculty of Medicine, Universitas Indonesia, Depok, Indonesia |
Pratiwi, R.Y., Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Elya, B., Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Setiawan, H., Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Solawati, A., Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Rosmalena, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia |
Introduction: New preventive and therapeutic strategies to treat Type 2 diabetes (T2D) continue to be pursued, the complexity of this disease makes it imperative to establish preclinical animal models which must provide accurate similarities to the pathogenesis of diabetes in humans. Making a diabetic animal model using rats with high-fat diet (HFD)-streptozotocin (STZ) induction is popular because it is relatively low cost and simple. Objectives: This study aims to analyse the changes in body weight, blood glucose, and lipid profiles that occur in diabetic rat models created by induction of HFD in combination with lowdose STZ. Methods: This study used forty male Sprague-Dawley rats (200-240 g). After the adaptation period, thirty rats were fed with HFD for 28 days (DM group), while the other ten rats continued to be fed with standard feed (NC group). After then, diabetes was induced to the DM group by low-dose STZ (35 mg/kg BW). The body weight of the rats was measured before and after diet manipulation periods. Blood samples were taken before and after STZ induction to determine lipid profiles and blood glucose levels. Results: During the diet manipulation period, the HFD group experienced a significantly greater weight gain, higher blood glucose levels, and cholesterol (TC) levels. After STZ injection, rats' blood glucose levels, TC, and triglycerides significantly increased. Conclusion: HFD feeding combined with a low-dose STZ effectively work to mimic specific condition that is similar to T2D, and the stability of the experimental animal conditions remains constant for up to 6 weeks. © 2021 Phcogj.Com. |
Diabetes; Diabetic animal model; High-fat diet; Insulin resistance; Low-dose streptozotocin; Stable diabetes type 2 profile |
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EManuscript Technologies |
09753575 |
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Article |
Q3 |
268 |
15961 |
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