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199 |
Tunjungputri R.N., Tetrasiwi E.N., Veronica M., Pandelaki J., Ibrahim F., Nelwan E.J. |
56342194400;57267704700;57268337000;35759266900;57226400046;14527452900; |
Vaccine-associated disease enhancement: a case report of post-vaccination COVID-19 |
2021 |
International Journal of Antimicrobial Agents |
58 |
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21003575 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115401929&doi=10.1016%2fj.ijantimicag.2021.106421.86&partnerID=40&md5=46457ba71f5610aae7b204755fcef50d |
Department of Internal Medicine, Faculty of Medicine Universitas Indonesia and Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Radiology, Faculty of Medicine Universitas Indonesia and Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Microbiology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Tropical and Infectious Diseases, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia and Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Infectious Disease and Immunology Research Center—IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Tunjungputri, R.N., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia and Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Tetrasiwi, E.N., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia and Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Veronica, M., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia and Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Pandelaki, J., Department of Radiology, Faculty of Medicine Universitas Indonesia and Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Ibrahim, F., Microbiology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Nelwan, E.J., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia and Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia, Division of Tropical and Infectious Diseases, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia and Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia, Infectious Disease and Immunology Research Center—IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
[No abstract available] |
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Elsevier B.V. |
09248579 |
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Article |
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1454 |
2387 |
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200 |
Fadrian F., Nelwan E.J., Kurniawan J., Pohan H.T. |
57268114000;14527452900;57193251655;23474782900; |
Risk of infection with multiple pathogen in post liver transplantation patient in referral centre in Jakarta, Indonesia |
2021 |
International Journal of Antimicrobial Agents |
58 |
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21003320 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115366248&doi=10.1016%2fj.ijantimicag.2021.106421.61&partnerID=40&md5=e23afb1d78408e73580d689f6327bb02 |
Department of Internal Medicine;; Division of Tropical and Infectious Disease;; Division of Hepatology Faculty of Medicine Universitas Indonesia, Ciptomangunkusumo Hospital, Jakarta, Indonesia |
Fadrian, F., Department of Internal Medicine;; Nelwan, E.J., Department of Internal Medicine;, Division of Tropical and Infectious Disease;; Kurniawan, J., Department of Internal Medicine;, Division of Hepatology Faculty of Medicine Universitas Indonesia, Ciptomangunkusumo Hospital, Jakarta, Indonesia; Pohan, H.T., Department of Internal Medicine;, Division of Tropical and Infectious Disease; |
[No abstract available] |
aspergillosis.; biloma; CMV; post liver transplantation infection |
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Elsevier B.V. |
09248579 |
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Article |
Q1 |
1454 |
2387 |
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201 |
Tunjungputri R.N., Tetrasiwi E.N., Rizqa T., Mulansari N.A., Harimurti K. |
56342194400;57267704700;57268337300;36519326000;23473513200; |
Parenteral and oral anticoagulant treatment for hospitalized and post-discharge patients with COVID-19: A systematic review |
2021 |
International Journal of Antimicrobial Agents |
58 |
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21003587 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115349747&doi=10.1016%2fj.ijantimicag.2021.106421.87&partnerID=40&md5=c258c13fa4bd248528cd36e04d4d4fd4 |
Department of Internal Medicine, Universitas Indonesia, Faculty of Medicine and Cipto Mangunkusumo National Centre General Hospital;; Division of Hematology and Medical Oncology, Department of Internal Medicine, Universitas Indonesia, Faculty of Medicine and Cipto Mangunkusumo National Centre General Hospital |
Tunjungputri, R.N., Department of Internal Medicine, Universitas Indonesia, Faculty of Medicine and Cipto Mangunkusumo National Centre General Hospital;; Tetrasiwi, E.N., Department of Internal Medicine, Universitas Indonesia, Faculty of Medicine and Cipto Mangunkusumo National Centre General Hospital;; Rizqa, T., Department of Internal Medicine, Universitas Indonesia, Faculty of Medicine and Cipto Mangunkusumo National Centre General Hospital;; Mulansari, N.A., Division of Hematology and Medical Oncology, Department of Internal Medicine, Universitas Indonesia, Faculty of Medicine and Cipto Mangunkusumo National Centre General Hospital; Harimurti, K., Department of Internal Medicine, Universitas Indonesia, Faculty of Medicine and Cipto Mangunkusumo National Centre General Hospital; |
[No abstract available] |
anticoagulant; COVID-19; thromboprophylaxis.; VTE |
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Elsevier B.V. |
09248579 |
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Article |
Q1 |
1454 |
2387 |
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202 |
Rusdi N.K., Purwaningsih E.H., Hestiantoro A., Elya B., Kusmardi K. |
57211475250;57186723500;8743255100;14014224500;56966625300; |
In vivo antimammary tumor effects of soybean extract with targeted lunasin (ET-Lun) |
2021 |
Pharmacognosy Journal |
13 |
5 |
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1269 |
1276 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115297490&doi=10.5530%2fpj.2021.13.160&partnerID=40&md5=d96a1538654afeda0377ba6b0d8a5e38 |
Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. DR. Hamka, Jakarta, Indonesia; Department of Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department Obstetrics and Gynaecology, School of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Drug Development Research Cluster, Indonesian Medical Education and Reseach Institute, Universitas INDONESIA, Indonesia; Human Cancer Research Cluster, Indonesian Medical Education and Research Institute, Universitas INDONESIA, Indonesia |
Rusdi, N.K., Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. DR. Hamka, Jakarta, Indonesia; Purwaningsih, E.H., Department of Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Drug Development Research Cluster, Indonesian Medical Education and Reseach Institute, Universitas INDONESIA, Indonesia; Hestiantoro, A., Department Obstetrics and Gynaecology, School of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Elya, B., Department of Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Kusmardi, K., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Drug Development Research Cluster, Indonesian Medical Education and Reseach Institute, Universitas INDONESIA, Indonesia, Human Cancer Research Cluster, Indonesian Medical Education and Research Institute, Universitas INDONESIA, Indonesia |
Background/Objective: Lunasin is a peptide, consist of 44 amino acids which have anti-cancer, antioxidant, and anti-inflammatory activity. The price of commercial Lunasin was very expensive due to the high cost of lunasin synthesis and the lack of methods to obtain the pure lunasin weight from plant sources, involving time-consuming analytical instruments. To overcome these problems, the soybean extract with targeted Lunasin (ET-Lun) was made. The aim of this study was to investigate anti-cancer properties of ET-Lun in breast cancer models in vivo. Methods: Effect of ET-Lun was evaluated in 7,12-Dimetilbenz[a]antrasen (DMBA) induced breast cancer rat model. Tumor Mass, volume, and number were measured. The expression of HER2 and EGFR from each treatment group in DMBA-induced rat was evaluated using immunohistochemistry. Results: The results shown that ET-Lun could reduced tumor volume (p=0,021). ET-Lun decreased EGFR expression compared to negative control DMBA (p=0,012). Conclusions: These results indicated that the ET-Lun has anti-breast cancer activity in vivo. © 2021 Phcogj.Com. |
Breast cancer; EGFR; HER2; In-vivo; Soybean |
dimethylbenz[a]anthracene; epidermal growth factor receptor; epidermal growth factor receptor 2; lunasin; peptide; soybean extract; tamoxifen; unclassified drug; aged; animal experiment; animal model; animal tissue; antineoplastic activity; Article; breast cancer; controlled study; female; immunohistochemistry; in vivo study; nonhuman; protein expression; rat; soybean; tumor number; tumor volume |
EManuscript Technologies |
09753575 |
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Article |
Q3 |
268 |
15961 |
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204 |
Heltty H., Sitorus R., Martha E., Nusdwinuringtyas N. |
57262112500;57194329674;55841280100;56608215500; |
Experience of the patient's success in facing post-stroke urinary incontinence: The patient's perspective |
2021 |
Frontiers of Nursing |
8 |
3 |
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291 |
301 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115061619&doi=10.2478%2ffon-2021-0030&partnerID=40&md5=9c066e6d2b1fc65cd5adc1fc8034247d |
Faculty of Nursing, Medical Surgical, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia; Faculty of Public Health, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia; Faculty of Medicine, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia |
Heltty, H., Faculty of Nursing, Medical Surgical, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia; Sitorus, R., Faculty of Nursing, Medical Surgical, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia; Martha, E., Faculty of Public Health, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia; Nusdwinuringtyas, N., Faculty of Medicine, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia |
Objective: Post-stroke urinary incontinence (UI) is one of the sequelae of stroke. This situation affects all aspects of the patient's life - physically, psychologically, socially, and spiritually. This study aimed to investigate the experience of patients' success in facing a post-stroke UI. Methods: A qualitative study using the Rapid Assessment Procedure (RAP) approach was used in this study. Informants were selected using purposive sampling. In-depth interviews with as many as 8 patients who had recovered from post-stroke UI and living in the greater area of Southeast Sulawesi (Indonesia) were conducted. In-depth interviews were also conducted with 8 caregivers and 2 nurses. Data were analyzed using a thematic analysis approach and interpretation of data was based on Humanbecoming theory and Self-care deficit theory of nursing. Results: Five successful things the patients experienced during post-stroke UI were identified. The five successes were as follows: they provided information to get to know and understand post-stroke UI, followed the procedures to overcome post-stroke UI, conducted self-control exercises and stayed motivated, performed daily activities independently according to ability, and made use of family support and peers' attention. Conclusions: These findings indicated that persistence, belief, independence, and social support (family and peer) made patients to successfully face their post-stroke UI and improved their quality of life. These findings also became the basis for developing a post-stroke UI management model based on Humanbecoming theory and Self-care deficit theory of nursing. © 2021 Heltty Heltty et al., published by Sciendo. |
experience of patient's success; patient's perspective; post-stroke urinary incontinence |
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Sciendo |
25448994 |
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Review |
Q4 |
152 |
22962 |
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205 |
Krisanti E.A., Gofara T.Z., Rahyussalim A.J., Mulia K. |
14019920500;57260804700;55212166100;6507666535; |
Polyvinyl alcohol (PVA)/chitosan/sodium tripolyphosphate (STPP) hydrogel formulation with freeze-thaw method for anti-tuberculosis drugs extended release |
2021 |
AIP Conference Proceedings |
2370 |
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020010 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115001335&doi=10.1063%2f5.0063175&partnerID=40&md5=a3c9afce6e9d9f6305976a87eb3a4790 |
Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia; Department of Orthopedic and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia |
Krisanti, E.A., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia; Gofara, T.Z., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia; Rahyussalim, A.J., Department of Orthopedic and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Mulia, K., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia |
Tuberculosis (TB) is one of the infectious diseases which must be routinely oral treated with anti-tuberculosis drugs performed 12-24 months. With treatment using drug implans that can release TB drugs in a longer time in the target location, it will be more effective, because the drug will be close to the target and go directly into the blood. In this study, the PVA / chitosan / STPP hydrogel formulation loaded with 4 types of anti-tuberculosis drugs (isoniazid, ethambutol, pirazinamide, and rifampicin) made using the freeze-thaw method. It is obtained that chitosan addition up until 20% could reduce drug's release rate and hold drug's release until 30 days, but the effect of STPP addition could not be seen because the ammount added is too small which is also shown from FTIR study that there is no STPP in the hydrogel detected. 80% PVA-20% Chitosan- 2% STPP hydrogel formulation release TB drugs the slowest and extended on Isoniazid, Ethambutol, and Rifampicin. SEM study shown that chitosan addition in PVA hydrogel resulted a homogen solution, and hydrogel with densely folded surface. 2% STPP addition resulted in smoother, more homogenous, and smaller pores morphology. © 2021 Author(s). |
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American Institute of Physics Inc. |
0094243X |
9780735441262 |
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Conference Paper |
- |
177 |
20880 |
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207 |
Kartini D., Panigoro S.S., Ham M.F., Harahap A.S., Rasyid S.H., Marcevianto K.V. |
57215490523;56790104300;57257336600;57218511857;57224779056;57256764400; |
Thyroid hemiagenesis associated with Hurthle cell carcinoma: A case report |
2021 |
International Journal of Surgery Case Reports |
86 |
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106372 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114820796&doi=10.1016%2fj.ijscr.2021.106372&partnerID=40&md5=a842dbe995f6b1a20d9b986dad8aad97 |
Surgical Oncology Division, Department of Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Pathological Anatomy, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia |
Kartini, D., Surgical Oncology Division, Department of Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Panigoro, S.S., Surgical Oncology Division, Department of Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Ham, M.F., Department of Pathological Anatomy, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Harahap, A.S., Department of Pathological Anatomy, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Rasyid, S.H., Surgical Oncology Division, Department of Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Marcevianto, K.V., Surgical Oncology Division, Department of Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia |
Introduction and importance: Thyroid hemiagenesis (TH) is a rare congenital anomaly where one lobe fails to develop, especially more frequently occurs on the left lobe. The exact mechanisms for thyroid morphogenesis remain unclear. In this paper, we report a rare case of right lobe TH associated with Hurthle cell carcinoma. Case presentation: A 59 years old woman was admitted with a neck lump increasing in size in the last 20 years. There were no symptoms of hyperthyroidism and hypothyroidism. There was a palpable, painless 5 cm mass in the middle of the neck. Initial thyroid ultrasonography (USG) revealed an enlarged left lobe, with hypoechoic lesion with cystic component and calcification (TIRADS 4). However, the right lobe was non-visualized. Fine needle aspiration biopsy result tendency was a malignancy. Hence, isthmolobectomy was conducted. Pathology result was Hurthle cell carcinoma. On the ninth month, USG revealed fibrotic tissue in the right thyroid bed and bilateral lymphadenopathy. Due to discrepancy, the patient was planned for a neck exploration surgery and a right lobe incision. Intraoperatively, the right thyroid was absent. Intraoperative USG also confirmed no right thyroid lobe. Discussion: Thyroid hemiagenesis can be visualized by using USG due to its practicality and cost effectiveness reasons. Follow up evaluations consisted of systematic monitoring of thyroid morphology and hormonal functions should follow the diagnosis of TH. Neck exploration surgery might need to be performed to clarify any discrepancy and confirm the diagnosis. Conclusion: TH can be recognized through supporting examination; however, discrepancy may occur. © 2021 The Authors |
Hurthle cell carcinoma; Neck exploration surgery; Thyroid hemiagenesis |
euthyrax; levothyroxine sodium; thyroglobulin; adult; Article; calcification; cancer diagnosis; cancer size; cancer surgery; case report; clinical article; color Doppler flowmetry; echography; female; fine needle aspiration biopsy; frozen section; histopathology; human; human tissue; incision; isthmolobectomy; lobectomy; lymph node; lymphadenopathy; middle aged; neck; neck tumor; parathyroid gland; physical examination; recurrent laryngeal nerve; thyroglobulin blood level; thyroid carcinoma; thyroid dysgenesis; thyroid hemiagenesis; thyroid lobe; thyroid parafollicular cell; thyroid surgery; vascularization; vein ligation |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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210 |
Nurhayati R.W., Cahyo R.D., Pratama G., Anggraini D., Mubarok W., Kobayashi M., Antarianto R.D. |
55748436600;57212460506;57195959221;57221606578;57208440063;20835016200;57190862806; |
Alginate-chitosan microencapsulated cells for improving cd34+ progenitor maintenance and expansion |
2021 |
Applied Sciences (Switzerland) |
11 |
17 |
7887 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114106674&doi=10.3390%2fapp11177887&partnerID=40&md5=8aa18a5d52c69e6eb72dcb38252f4489 |
Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Jl. Prof. Soemantri Brojonegoro, Kampus UI, Depok, 16424, Indonesia; Stem Cells & Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia; Department of Biotechnology, Faculty of Engineering, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan; Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jl. Diponegoro No. 71, Central Jakarta, 10430, Indonesia; Integrated Service Unit of Stem Cell Medical Technology (IPT TK Sel Punca), Dr. Cipto Mangunkusumo General Hospital (RSCM), Jl. Diponegoro No. 71, Salemba, Central Jakarta, 10430, Indonesia; Division of Materials Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, 630-0192, Japan; Division of Chemical Engineering, Department of Materials Engineering Science, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama-cho, Toyonaka, Osaka, 560-8531, Japan; Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, 630-0192, Japan; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia |
Nurhayati, R.W., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Jl. Prof. Soemantri Brojonegoro, Kampus UI, Depok, 16424, Indonesia, Stem Cells & Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia; Cahyo, R.D., Stem Cells & Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia, Department of Biotechnology, Faculty of Engineering, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan; Pratama, G., Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jl. Diponegoro No. 71, Central Jakarta, 10430, Indonesia, Integrated Service Unit of Stem Cell Medical Technology (IPT TK Sel Punca), Dr. Cipto Mangunkusumo General Hospital (RSCM), Jl. Diponegoro No. 71, Salemba, Central Jakarta, 10430, Indonesia; Anggraini, D., Stem Cells & Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia, Division of Materials Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, 630-0192, Japan; Mubarok, W., Stem Cells & Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia, Division of Chemical Engineering, Department of Materials Engineering Science, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama-cho, Toyonaka, Osaka, 560-8531, Japan; Kobayashi, M., Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, 630-0192, Japan; Antarianto, R.D., Stem Cells & Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia, Department of Histology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia |
Protocols for isolation, characterization, and transplantation of hematopoietic stem cells (HSCs) have been well established. However, difficulty in finding human leucocyte antigens (HLA)-matched donors and scarcity of HSCs are still the major obstacles of allogeneic transplanta-tion. In this study, we developed a double-layered microcapsule to deliver paracrine factors from non-matched or low-matched HSCs to other cells. The umbilical cord blood-derived hematopoietic progenitor cells, identified as CD34+ cells, were entrapped in alginate polymer and further protected by chitosan coating. The microcapsules showed no toxicity for surrounding CD34+ cells. When CD34+ cells-loaded microcapsules were co-cultured with bare CD34+ cells that have been collected from unrelated donors, the microcapsules affected surrounding cells and increased the percentage of CD34+ cell population. This study is the first to report the potency of alginate-chitosan microcap-sules containing non-HLA-matched cells for improving proliferation and progenitor maintenance of CD34+ cells. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Alginate; CD34; Chitosan; Hematopoietic; Megakaryocyte; Microencapsulation; Progenitor; Proliferation; Stem cells |
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MDPI |
20763417 |
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Article |
Q2 |
435 |
11324 |
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212 |
Librianto D., Aprilya D. |
57192894799;57193710642; |
Cantilever method for severe kyphotic deformity correction in spondylitis tuberculosis: A technical note and literature review |
2021 |
Annals of Medicine and Surgery |
69 |
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102764 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113387050&doi=10.1016%2fj.amsu.2021.102764&partnerID=40&md5=65a7cd7e9c389e8ea978726e602d9fe3 |
Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Fatmawati General Hospital, Jakarta, Indonesia; Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Librianto, D., Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Fatmawati General Hospital, Jakarta, Indonesia; Aprilya, D., Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: The kyphotic deformity is more than just a cosmetic disfigurement. It is potentially life-threatening and disturbs the quality of life by causing cardiopulmonary dysfunction, spinal imbalance, and other associated problems. Corrective surgery is challenging but it is needed to bring the spinal balance back thus halting the progressiveness of the deformity. The cantilever technique is a gold standard to correct the sagittal plane deformity. Methods: This is a review article with some case illustrations from Author's experience. Objective: We aim to review the cantilever technique for kyphotic correction in spondylitis tuberculosis patients. Conclusion: The cantilever technique is the standard for sagittal plane deformity correction that can be applied for kyphotic deformity correction in spondylitis tuberculosis cases. Developing the safest techniques and instrumentation is crucial to achieving spinal balance with minimal risk of morbidities. © 2021 |
Cantilever method; Deformity correction; Kyphotic deformity; Spondylitis tuberculosis |
cosmetic; backache; biopsy; bone graft; cardiopulmonary insufficiency; comorbidity; decortication; deformity; follow up; gold standard; graft failure; human; kyphosis; laminectomy; morbidity; nerve injury; nuclear magnetic resonance imaging; osteotomy; pain; quality of life; Review; screw loosening; spinal cord decompression; spinal cord lesion; spine malformation; systematic review; tissue culture; tuberculous spondylitis; vascularization |
Elsevier Ltd |
20490801 |
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Review |
Q3 |
391 |
12334 |
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218 |
Fachniadin A., Widi Nugroho S., Ananda Aman R., Ichwan S., Tandian D., Susanto E., Watanabe K., Nonaka Y. |
57222123314;57219659664;57222125502;57192906639;57192891173;57204423225;55704851200;36344004800; |
A Dumbbell-shaped hypoglossal schwannoma managed by a combination of open surgery and endoscopic assistance |
2021 |
Interdisciplinary Neurosurgery: Advanced Techniques and Case Management |
25 |
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101102 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101531664&doi=10.1016%2fj.inat.2021.101102&partnerID=40&md5=aa132c91fdc36c35a156948ab70bdf91 |
Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Neurosurgery, Tokyo Jikei University School of Medicine, Tokyo, Japan; Department of Neurosurgery, Tokai University School of Medicine, Tokyo, Japan |
Fachniadin, A., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Widi Nugroho, S., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Ananda Aman, R., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Ichwan, S., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Tandian, D., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Susanto, E., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Watanabe, K., Department of Neurosurgery, Tokyo Jikei University School of Medicine, Tokyo, Japan; Nonaka, Y., Department of Neurosurgery, Tokai University School of Medicine, Tokyo, Japan |
Background: Hypoglossal schwannoma is a rare benign tumor that comprises about 5% of all intracranial schwannoma. Surgical management for hypoglossal schwannoma is still evolving along with our understanding of neuroanatomy and surgical equipment improvement, especially endoscopy. The far lateral transcondylar approach is commonly used for hypoglossal schwannomas. This traditional approach requires great effort and is considered a lengthy procedure. The use of endoscopy gives an additional advantage to microscopic surgery in managing this tumor, making surgery less complicated and faster. Combining the microscope and endoscope is an effective way to operate in small corridors. Case: In a stepwise fashion, we present a case of a 53-year-old female with hypoglossal schwannoma, which was successfully resected using a retrosigmoid transcondylar approach with endoscopic assistance. Conclusion: A retrosigmoid transcondylar approach with endoscopic assistance is an excellent option in surgical management for hypoglossal schwannoma. Both microscopic and endoscopic approaches will be gaining more usefulness in managing skull base tumors and should be used collaboratively. © 2021 The Authors |
Dumbbell-shaped; Endoscopic; Hypoglossal schwannoma; Retrosigmoid transcondylar |
corticosteroid; fibrin glue; accessory nerve; adult; Article; brain stem; breathing exercise; cancer surgery; case report; cerebral revascularization; chemodectoma; chondroma; clinical article; clinical examination; cranial nerve; craniotomy; differential diagnosis; Doppler flowmetry; drinking; dysphagia; eating; female; histopathology; hoarseness; hospital discharge; human; hypoglossal nerve; intraoperative monitoring; intraoperative neurophysiological monitoring; jugular foramen; liquorrhea; mastoid; medulla oblongata; meningioma; middle aged; mitosis rate; muscle atrophy; neurilemoma; neuroanatomy; neuroendoscopy; neuroimaging; neuromonitoring; neurorehabilitation; nuclear magnetic resonance imaging; open surgery; paraganglioma; paralysis; parapharyngeal space; periosteum; physical exam |
Elsevier B.V. |
22147519 |
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Q4 |
202 |
19207 |
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