499 |
Pangjaya L.F., Khaerunnisa S., Mazfufah N.F., Budiman R.L., Antarianto R.D. |
57222624829;57221948155;57215595521;57222627263;57190862806; |
Investigating different type of ovary cancer cell line for NK cell in vitro co-culture cytotoxic assay |
2021 |
AIP Conference Proceedings |
2344 |
|
040010 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103511346&doi=10.1063%2f5.0049155&partnerID=40&md5=34e5a053702d387eeb6890faa2868915 |
Biology Undergraduate Program, Faculty of Mathematics and Natural Science, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia; Department of Biology, Faculty of Mathematics and Natural Science, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia |
Pangjaya, L.F., Biology Undergraduate Program, Faculty of Mathematics and Natural Science, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia; Khaerunnisa, S., Biology Undergraduate Program, Faculty of Mathematics and Natural Science, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia; Mazfufah, N.F., Department of Biology, Faculty of Mathematics and Natural Science, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Budiman, R.L., Department of Biology, Faculty of Mathematics and Natural Science, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Antarianto, R.D., Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia, Department of Histology, Faculty of Medicine, Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia |
Ovarian cancer is one of the gynecologic cancers with a high mortality rate and increased incidence. Surgery and therapies are used to treat ovarian cancer patients. Therapies such as chemotherapy and radiotherapy can cause resistance therefore immunotherapy using natural killer (NK) cells can be an alternative therapy. NK cells have shown an important role in anticancer activity because it is able to kill target cells without prior sensitization and can acquire immunology memory. However, NK cells as immunotherapy have low capacity and efficacy on infiltrating ovarian cancer's tumor microenvironment. To overcome these NK cells need to be induced with certain antigen resulting in enhanced NK cells. Enhanced NK cells display a higher cytotoxic activity that can be seen by co-culturing enhanced NK cells with ovarian cancer cell lines. In this mini-review, the selection of ovarian cancer cell lines was displayed to offer reliable consideration to obtain the expected research endpoint. © 2021 Author(s). |
co-culture; cytotoxic assay; NK cells; ovarian cancer; ovarian cancer cell lines |
|
American Institute of Physics Inc. |
0094243X |
9780735440869 |
|
Conference Paper |
- |
177 |
20880 |
|
|
507 |
Khaerunnisa S., Pangjaya L.F., Mazfufah N.F., Budiman R.L., Antarianto R.D. |
57221948155;57222624829;57215595521;57222627263;57190862806; |
Nidogen-1 (NID1) as specific ligand in natural killer (NK) cells stimulated from advanced ovarian cancer: Immunotherapy review |
2021 |
AIP Conference Proceedings |
2344 |
|
040009 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103487578&doi=10.1063%2f5.0049157&partnerID=40&md5=c45066e93f8193a8972229dcd9d4bfb0 |
Biology Undergraduate Program, Faculty of Mathematics and Natural Science, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia; Department of Biology, Faculty of Mathematics and Natural Science, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia |
Khaerunnisa, S., Biology Undergraduate Program, Faculty of Mathematics and Natural Science, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia; Pangjaya, L.F., Biology Undergraduate Program, Faculty of Mathematics and Natural Science, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia; Mazfufah, N.F., Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia; Budiman, R.L., Department of Biology, Faculty of Mathematics and Natural Science, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Antarianto, R.D., Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia, Department of Histology, Faculty of Medicine, Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia |
The pathway for the introduction of NK cell into abnormal cells is mediated by the receptor-ligand interaction on the cell surface. Among all the activation receptors, NKP44 has become a unique activation receptor because it has an ITIMs signaling pathway and actively plays an important role in several functions of stimulated NK cells. A potential ligand that can specifically regulate the activity of NKP44 receptors is NID1. NID1 is a novel ligand that can initiate two different regulations on NK cells activity. In addition, NID1 also provides predictions that are compatible with the electrophoretic glycoprotein mobility that has been detected by NKp44 through SDS-PAGE and ELISA tests compared to all proteins in the microenvironment of ovarian cancer. Curently, NID1 has been proven to be able to increase the cytotoxic reaction of non-cancerous NK cells. Further research is needed for the development of ovarian cancer immunotherapy based on the receptor-ligand interactions. © 2021 Author(s). |
immunotherapy; NID1; NK cell; NKP44; ovary cancer |
|
American Institute of Physics Inc. |
0094243X |
9780735440869 |
|
Conference Paper |
- |
177 |
20880 |
|
|