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690	Yunihastuti E., Rusdi L., Azizi M.S., Estiasari R., Jasirwan C.O.M., Wulandari E.A.T., Purnamasari D., Noviar M.S., Nasution S.A.	57221273925;57193236387;57299671700;55240204000;55192478000;57211220361;36519537700;57300045000;57189373134;	Effect of atorvastatin on subclinical atherosclerosis in virallysuppressed HIV-infected patients with CMV seropositivity: a randomized double-blind placebo-controlled trial	2021	F1000Research	10			1	11		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117326016&doi=10.12688%2fF1000RESEARCH.28262.1&partnerID=40&md5=8cf9d3ac5f159644680ab91c18126cb9	Allergy and Clinical Immunology Division, Internal Medicine Department, University of Indonesia Faculty of Medicine; Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; HIV Integrated Clinic, Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Cardiology Division, Internal Medicine Department, University of Indonesia Faculty of Medicine; Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Neurology Department, University of Indonesia Faculty of Medicine; Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Hepatobiliary Division, Internal Medicine Department, University of Indonesia Faculty of Medicine; Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Dentistry Department, University of Indonesia Faculty of Medicine; Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Metabolic Endocrine Division, Internal Medicine Department, University of Indonesia Faculty of Medicine; Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia	Yunihastuti, E., Allergy and Clinical Immunology Division, Internal Medicine Department, University of Indonesia Faculty of Medicine; Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia, HIV Integrated Clinic, Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Rusdi, L., Cardiology Division, Internal Medicine Department, University of Indonesia Faculty of Medicine; Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Azizi, M.S., Cardiology Division, Internal Medicine Department, University of Indonesia Faculty of Medicine; Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Estiasari, R., Neurology Department, University of Indonesia Faculty of Medicine; Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Jasirwan, C.O.M., Hepatobiliary Division, Internal Medicine Department, University of Indonesia Faculty of Medicine; Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Wulandari, E.A.T., Dentistry Department, University of Indonesia Faculty of Medicine; Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Purnamasari, D., Metabolic Endocrine Division, Internal Medicine Department, University of Indonesia Faculty of Medicine; Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Noviar, M.S., HIV Integrated Clinic, Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Nasution, S.A., Cardiology Division, Internal Medicine Department, University of Indonesia Faculty of Medicine; Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia	Background: Persistent immune activation and inflammation in HIVinfection are linked to excess cardiovascular risk and other noncommunicable diseases. Periodic asymptomatic CMV-reactivity in HIV infected patients over a lifetime may contribute to non-AIDS defining morbidity. Despite undetectable levels of HIV and CMV, these patients continue to have increased levels of biomarkers and immune activations. Statin administration is thought to reduce subclinical atherosclerosis by decreasing LDL-C levels. It may also add beneficial effects against CMV infection. Methods: We are conducting a double-blind placebo-controlled trial in which patients are randomized to receive either atorvastatin or placebo with a ratio of 1:1. This trial aims to study the effect of atorvastatin in statin-naive virally-suppressed HIV-infected patients with stable ART and CMV seropositivity on carotid intima media thickness (CIMT), tool that evaluates subclinical atherosclerosis. The study recruits 80 patients at HIV integrated care unit of Cipto Mangunkusumo hospital. All eligible subjects have CIMT evaluation as primary outcome, along with flow mediated vasodilatation (FMD), liver fibrosis and steatosis evaluation, fasting lipid, neurocognitive test, community periodontal index (CPI), and residual immune activation as secondary outcomes in 48 weeks. Ethics and dissemination: This study has received an ethical approval from Health Research Ethics Commitee–Universitas Indonesia and Cipto Mangunkusumo Hospital. Before joining the study, all participants fill in an informed consent form. At the end of study analysis, the trial results will be published and disseminated in peerreviewed journals. Discussion: The main purpose of our study is to evaluate the effect of atorvastatin administration on CIMT changes in statin naïve virally suppressed HIV-infected patients with stable ART and CMV seropositivity Registration: ClinicalTrials.gov ID NCT04101136; registered on 24 September 2019. © 2021. Yunihastuti E et al.	atherosclerosis; atorvastatin; cognitive dysfunction; cytomegalovirus; HIV; non alcoholic fatty liver; periodontitis		F1000 Research Ltd	20461402		Article	Q1	1099	3793	View
694	Kusmardi K., Wiyarta E., Rusdi N.K., Maulana A.M., Estuningtyas A., Sunaryo H.	56966625300;57221521342;57211475250;57290003500;55650360200;57214674652;	The potential of lunasin extract for the prevention of breast cancer progression by upregulating E-Cadherin and inhibiting ICAM-1	2021	F1000Research	10		902				https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116770885&doi=10.12688%2ff1000research.55385.1&partnerID=40&md5=c9ffe7db1754323884964582b04aceb3	Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia; Drug Development Research Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia; Human Cancer Research Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia; Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia; Faculty of Pharmacy and Science, Universitas Muhammadiyah Prof. DR. Hamka, Limau II Street, Jakarta, 12130, Indonesia; Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia; Faculty of Medicine, University of Muhammadiyah Purwakarta, KH. Ahmad Dahlan Street, Central Java, 53182, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia	Kusmardi, K., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia, Drug Development Research Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia, Human Cancer Research Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia; Wiyarta, E., Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia; Rusdi, N.K., Faculty of Pharmacy and Science, Universitas Muhammadiyah Prof. DR. Hamka, Limau II Street, Jakarta, 12130, Indonesia, Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia; Maulana, A.M., Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia, Faculty of Medicine, University of Muhammadiyah Purwakarta, KH. Ahmad Dahlan Street, Central Java, 53182, Indonesia; Estuningtyas, A., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia; Sunaryo, H., Faculty of Pharmacy and Science, Universitas Muhammadiyah Prof. DR. Hamka, Limau II Street, Jakarta, 12130, Indonesia, Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia	Background: Research in natural substances for their anticancer potential has become increasingly popular. Lunasin, a soybean protein, is known to inhibit cancer progression via various pathways. The aim of this study was to investigate the effect of Lunasin Extract (LE) on the expression of Intercellular Adhesion Molecule 1 (ICAM-1) and epithelial cadherins (E-Cadherin) in breast cancer. Methods: In this true-experimental in vivo study, 24 Sprague-Dawley rats that were induced by 7,12-Dimethylbenz[a]anthracene (DMBA), were used. Based on the therapy given, the groups were divided into, normal, positive control (PC), negative control (NC), adjuvant, curative, and preventive. Lunasin was extracted from soybean seeds of the Grobogan variety in Indonesia. Tissue samples were obtained, processed, stained with anti-ICAM-1 and anti-E-Cadherin antibodies, examined under a microscope, and quantified using H-score. The data were analyzed using ANOVA, which was then followed by Duncan's test. Results: Statistically significant difference in ICAM-1 expression was observed between the following groups: adjuvant and NC, normal and NC, PC and NC, adjuvant and preventive, normal and preventive, PC and preventive, adjuvant and curative, normal and curative, PC and curative. E-Cadherin expression was significantly different between preventive and NC, adjuvant and NC, PC and NC, normal and NC, adjuvant and curative, PC and curative, normal and curative, normal and preventive. Significant negative correlation was found between ICAM-1 and E-Cadherin [-0.616 (-0.8165; -0.283)] with p = 0.001. Conclusion: Preventive dose of LE was able to reduce ICAM-1 expression while increasing E-Cadherin expression. © 2021 Kusmardi K et al.	Breast Cancer; Cancer Prevention; E-Cadherin; ICAM-1; Lunasin	7,12 dimethylbenz[a]anthracene; intercellular adhesion molecule 1; lunasin; soybean protein; tamoxifen; unclassified drug; uvomorulin; cadherin; intercellular adhesion molecule 1; plant extract; soybean protein; animal experiment; animal model; animal tissue; Article; breast cancer; cancer adjuvant therapy; cancer inhibition; cancer prevention; controlled study; female; in vivo study; Indonesia; microscopy; nonhuman; plant seed; protein expression; rat; soybean; Sprague Dawley rat; statistical significance; treatment duration; upregulation; animal; neoplasm; Animals; Cadherins; Intercellular Adhesion Molecule-1; Neoplasms; Plant Extracts; Rats; Rats, Sprague-Dawley; Soybean Proteins	F1000 Research Ltd	20461402	34691393	Article	Q1	1099	3793	View
733	Maulani C., C Masulili S.L., Santoso W.D., Soedarsono N., Kusdhany L., Auerkari E.I.	57205060934;57226076327;6506080422;14049161500;55301180900;10139113000;	Association of subgingival Epstein-Barr virus and periodontitis	2021	F1000Research	10			414			https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112635068&doi=10.12688%2ff1000research.52624.1&partnerID=40&md5=0f76116d02cb7eb0372cd72bb0c00912	Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia; Department of Periodontology, Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas IndonesiaJakarta 10430, Indonesia; Department of Oral Biology, Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia; Department of Prosthodontics, Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia	Maulani, C., Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia; C Masulili, S.L., Department of Periodontology, Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia; Santoso, W.D., Department of Internal Medicine, Faculty of Medicine, Universitas IndonesiaJakarta 10430, Indonesia; Soedarsono, N., Department of Oral Biology, Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia; Kusdhany, L., Department of Prosthodontics, Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia; Auerkari, E.I., Department of Oral Biology, Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia	Background: The Epstein-Barr virus (EBV) is gaining interest as a possible agent in the etiology of periodontitis. Previous studies have shown controversy on whether EBV DNA in the subgingival periodontal pockets is associated with periodontitis. The aim of the present study was to seek the potential relationship between EBV and periodontitis. Methods: Data on socio-demographics, oral health, and periodontal health were recorded, and samples were collected from gingival crevicular fluid, using sterile paper point. This case-control study of 118 participants included 59 subjects with severe periodontitis and 59 control subjects with mild periodontitis. The EBV load was determined by quantitative real-time PCR. Results: EBV DNA was detected in 37.3% of the case samples and in 18.6% of the control samples. There was no significant difference in the load of EBV DNA between severe and mild periodontitis (p>0.05). The observed load of EBV DNA was up to 4.55x10 5 copies/mL. The detected EBV DNA was significantly associated with the plaque index and the oral hygiene index (all p<0.05). Conclusions: A significant association was not found, but EBV might contribute to periodontitis. Gingival crevicular fluid is useful for monitoring the EBV load by the real-time PCR technique. Copyright: © 2021 Maulani C et al.	Epstein-Barr Virus; Gingival Crevicular Fluid; Periodontitis	virus DNA; case control study; complication; Epstein Barr virus; Epstein Barr virus infection; human; periodontitis; Case-Control Studies; DNA, Viral; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Periodontitis	NLM (Medline)	20461402	34316360	Article	Q1	1099	3793	View
758	Auerkari E.I., Maulani C., C. Masulili S.L., Santoso W.D., Soedarsono N., Kusdhany L.	10139113000;57205060934;57226076327;6506080422;14049161500;55301180900;	Association of subgingival Epstein-Barr virus and periodontitis	2021	F1000Research	10		414				https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110298348&doi=10.12688%2ff1000research.52624.2&partnerID=40&md5=d21a6f40dceec542152f1e950acf5922	Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Prosthodontics, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia	Auerkari, E.I., Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Maulani, C., Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; C. Masulili, S.L., Department of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Santoso, W.D., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Soedarsono, N., Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Kusdhany, L., Department of Prosthodontics, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia	Background: The Epstein-Barr virus (EBV) is gaining interest as a possible agent in the etiology of periodontitis. Previous studies have shown controversy on whether EBV DNA in the subgingival periodontal pockets is associated with periodontitis. The present study aimed to seek the potential relationship between EBV and periodontitis. Methods: Samples were taken from gingival crevicular fluid using sterile paper points, and data on sociodemographics, oral health, and periodontal health were recorded. This case-control study of 118 participants included 59 subjects with severe periodontitis and 59 control subjects with mild periodontitis. Quantitative real-time PCR was used to determined EBV load. Results: EBV DNA was detected in 37.3% of the case samples and 18.6% of the control samples. There was no significant difference in a load of EBV DNA between severe and mild periodontitis (p>0.05). The observed load of EBV DNA was up to 4.55x10 5 copies/mL. The detected EBV DNA was significantly associated with the plaque index and the oral hygiene index (p<0.05). Conclusions: Although no significant association was found, EBV may play a role in periodontitis. The real-time PCR methods can be used to monitor the EBV load in gingival crevicular fluid. © 2021 Maulani C et al.	Epstein-Barr Virus; Gingival Crevicular Fluid; Periodontitis	adult; aged; Article; case control study; cementoenamel junction; clinical attachment level; controlled study; demography; dental caries; DNA extraction; enzyme immunoassay; Epstein Barr virus; female; gingiva bleeding; gingivitis; health; human; hygiene; lactation; major clinical study; male; mouth hygiene; nonhuman; oral hygiene index; oral hygiene index simplified; peer review; periodontal pocket depth; periodontitis; plaque index; proteomics; real time polymerase chain reaction; regulatory T lymphocyte; tooth root canal	F1000 Research Ltd	20461402	34316360	Article	Q1	1099	3793	View
767	Bachtiar E.W., Bachtiar B.M., Theodorea C.F., Tahapary D.L., Astrella C., Natalina N.	6507328763;15831189400;57190048861;55944492500;57210793320;57225210620;	A pilot study of red complex and three genera subgingival microbiome in periodontitis subjects with and without diabetes, evaluated by MinION platform	2021	F1000Research	10		79			1	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109577307&doi=10.12688%2ff1000research.28216.3&partnerID=40&md5=83c85f319460a8e5631506acfe142095	Department of Oral Biology and Oral Science Research Center, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia	Bachtiar, E.W., Department of Oral Biology and Oral Science Research Center, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Bachtiar, B.M., Department of Oral Biology and Oral Science Research Center, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Theodorea, C.F., Department of Oral Biology and Oral Science Research Center, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Tahapary, D.L., Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Astrella, C., Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Natalina, N., Department of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia	Background: Subgingival niche is one biofilm habitat containing rich microbiota, which plays an active role in maintaining the health of periodontal tissue and determining host response. As such, a study of changing subgingival biofilms is important for understanding the effect of a systemic condition. In this study, we compared the occurrence of six bacteria cohabiting in the subgingival area of periodontitis subjects, with (DP, n = 8) and without (NDP, n = 4) diabetes. Methods: The six genus and species of targeted bacteria were confirmed by 16S rRNA amplicon sequencing on MinION nanopore platform. Descriptive statistic was used to describe the obtained data. Results: We found that the six genus and species of targeted bacteria were detected but in different quantities in either group's periodontal pocket. Our data showed that Tannerella forsythia was the most abundant species in subgingival biofilms of the DP group of the red complex bacteria. In contrast, Aggregatibacter sp., which belongs to the phylum of proteobacteria, was present at a relatively lower level. In contrast, Fusobacterium sp., which belongs to orange complex bacteria, showed relative similarities in subgingival biofilms of both groups tested, while Veillonella sp., were abundant in the DP groups. Conclusions: Our data show that the diversity of classic periodontopathogens increased in the subgingival niche of periodontitis subjects with diabetes. It is the first study in Indonesia to apply MinION-based, full-length 16S rRNA amplicon sequencing in periodontitis patients with and without diabetes. © 2021 Bachtiar BM et al.	16S rRNA; Diabetes; MinION; Periodontitis; Red Complex bacteria; Subgingival Microbiome	RNA 16S; diabetes mellitus; genetics; gingiva; human; Indonesia; microflora; periodontitis; pilot study; Diabetes Mellitus; Gingiva; Humans; Indonesia; Microbiota; Periodontitis; Pilot Projects; RNA, Ribosomal, 16S	F1000 Research Ltd	20461402	34249333	Article	Q1	1099	3793	View
790	Wardhani S.O., Fajar J.K., Wulandari L., Soegiarto G., Purnamasari Y., Asmiragani A., Maliga H.A., Ilmawan M., Seran G., Iskandar D.S., Ndapa C.E., Hamat V., Wahyuni R.A., Cyntia L.O.S., Maarang F.M., Beo Y.A., Adar O.A., Rakhmadhan I.M., Shantikaratri E.T., Putri A.S.D., Wahdini R., Broto E.P., Suwanto A.W., Tamara F., Mahendra A.I., Winoto E.S., Krisna P.A., Harapan H.	57193196381;56156139600;52464692000;57193717004;57208736262;57222959533;57222334227;57217182580;57224455829;57224438531;57224439885;57224449332;57224455629;57224455121;57224456392;57224446473;57224439160;57224438662;57224448392;57224441818;57224441565;57224444725;57224449941;57192950403;57202301766;57215222980;57215221274;55844857500;	Association between convalescent plasma and the risk of mortality among patients with COVID-19: A meta-analysis	2021	F1000Research	10		64			3	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107586864&doi=10.12688%2ff1000research.36396.3&partnerID=40&md5=8ed63ca0af3edd475d763e27b3e86db9	Division of Hematology and Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, 60286, Indonesia; Division of Allergy and Immunology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, 60286, Indonesia; Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Biomedical Sciences, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Department of Midwifery, Faculty of Medicine, University Brawijaya, Malang, 65145, Indonesia; Department of Nursing, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Department of Neurosurgery, Faculty of Medicine, Universitas Airlangga, Surabaya, 60286, Indonesia; Department of Radiology, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia	Wardhani, S.O., Division of Hematology and Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Fajar, J.K., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Wulandari, L., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, 60286, Indonesia; Soegiarto, G., Division of Allergy and Immunology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, 60286, Indonesia; Purnamasari, Y., Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Asmiragani, A., Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Maliga, H.A., Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Ilmawan, M., Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Seran, G., Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Iskandar, D.S., Department of Biomedical Sciences, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Ndapa, C.E., Department of Midwifery, Faculty of Medicine, University Brawijaya, Malang, 65145, Indonesia; Hamat, V., Department of Midwifery, Faculty of Medicine, University Brawijaya, Malang, 65145, Indonesia; Wahyuni, R.A., Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Cyntia, L.O.S., Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Maarang, F.M., Department of Nursing, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Beo, Y.A., Department of Nursing, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Adar, O.A., Department of Midwifery, Faculty of Medicine, University Brawijaya, Malang, 65145, Indonesia; Rakhmadhan, I.M., Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Shantikaratri, E.T., Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Putri, A.S.D., Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Wahdini, R., Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Broto, E.P., Department of Neurosurgery, Faculty of Medicine, Universitas Airlangga, Surabaya, 60286, Indonesia; Suwanto, A.W., Department of Radiology, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Tamara, F., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Mahendra, A.I., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Winoto, E.S., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Krisna, P.A., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Harapan, H., Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia	Background: Convalescent plasma (CCP) has been used for treating some infectious diseases; however, the efficacy of CCP in coronavirus disease 2019 (COVID-19) remains controversial. The aim of this research was to assess the efficacy of CCP as an adjunctive treatment in COVID-19 patients. Methods: Embase, PubMed, Web of Science, Cochrane and MedRix were searched for potentially relevant articles. All included papers were assessed for the quality using modified Jadad scale and Newcastle-Ottawa scale for randomized controlled trial (RCT) and non - RCT, respectively. We used a Q test and Egger test to assess the heterogeneity and publication bias among studies, respectively. Mortality rates between patients treated with standard treatment and standard treatment with CCP were compared using a Z test. Results: A total of 12 papers consisting of three cross-sectional studies, one prospective study, five retrospective studies, and three RCT studies were included in our analysis. Of them, a total of 1,937 patients treated with CCP and 3,405 patients without CCP were included. The risk of mortality was 1.92-fold higher in patients without CCP compared to patients treated with CCP (OR: 1.92; 95%CI: 1.33, 2.77; p=0.0005). In severe COVID-19 sub-group analysis, we found that patients without CCP had a 1.32 times higher risk of mortality than those treated with CCP (OR: 1.32; 95%CI: 1.09, 1.60; p=0.0040). Conclusions: CCP, as adjunctive therapy, could reduce the mortality rate among COVID-19 patients. © 2021 Wardhani SO et al.	Convalescent plasma; COVID-19; Mortality; Outcomes; Passive immunization	convalescent plasma; Article; clinical effectiveness; clinical observation; consensus; coronavirus disease 2019; correlation analysis; data analysis software; disease association; disease severity; Egger test; fixed effect model; forest plot; high risk patient; human; kappa statistics; meta analysis; mortality risk; Newcastle-Ottawa scale; nonhuman; outcome assessment; passive immunization; publication bias; quality control; random effect model; randomized controlled trial (topic); risk reduction; sample size; statistical analysis; statistical model; study design; subgroup analysis; systematic review; Coronavirus infection; therapy; treatment outcome; Coronavirus Infections; COVID-19; Humans; Immunization, Passive; SARS-CoV-2; Treatment Outcome	F1000 Research Ltd	20461402	34136130	Article	Q1	1099	3793	View
855	Syahrul S., Maliga H.A., Ilmawan M., Fahriani M., Mamada S.S., Fajar J.K., Frediansyah A., Syahrul F.N., Imran I., Haris S., Rambe A.S., Emran T.B., Rabaan A.A., Tiwari R., Dhama K., Nainu F., Mutiawati E., Harapan H.	57216064819;57222334227;57217182580;57219947648;57211891425;56156139600;56897210000;57222337525;56589826700;57222343545;57193757980;55325267100;56049830800;55314856100;6507396956;57120069200;56652288600;55844857500;	Hemorrhagic and ischemic stroke in patients with coronavirus disease 2019: Incidence, risk factors, and pathogenesis - a systematic review and meta-analysis	2021	F1000Research	10		34			12	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102340647&doi=10.12688%2ff1000research.42308.1&partnerID=40&md5=8cfb8151ce9b8e51bb3ec5847e7a2ca5	Department of Neurology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Department of Neurology, Dr. Zainoel Abidin Hospital, Banda Aceh, Aceh, 23111, Indonesia; Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65117, Indonesia; Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Faculty of Pharmacy, Hasanuddin University, Makassar, South Sulawesi, 90245, Indonesia; Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Research Division for Natural Product Technology (BPTBA), Indonesian Institute of Sciences (LIPI), Wonosari, 55861, Indonesia; Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Neurology, Faculty of Medicine, Universitas Sumatera Utara, Medan, North Sumatra, 20155, Indonesia; Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, 4381, Bangladesh; Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran, 31311, Saudi Arabia; Department of Veterinary Microbiology and Immunology, College of Veterinary Sciences, UP Pandit Deen Upadhayay Pashu Chikitsa Vigyan Vishwavidyalay Evum Go-Anusandhan Sansthan (DUVASU), Mathura, Uttar Pradesh, 281 001, India; Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, 243122, India; Department of Microbiology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Tropical Disease Centre, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia	Syahrul, S., Department of Neurology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia, Department of Neurology, Dr. Zainoel Abidin Hospital, Banda Aceh, Aceh, 23111, Indonesia; Maliga, H.A., Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65117, Indonesia; Ilmawan, M., Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65117, Indonesia; Fahriani, M., Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Mamada, S.S., Faculty of Pharmacy, Hasanuddin University, Makassar, South Sulawesi, 90245, Indonesia; Fajar, J.K., Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65117, Indonesia, Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Frediansyah, A., Research Division for Natural Product Technology (BPTBA), Indonesian Institute of Sciences (LIPI), Wonosari, 55861, Indonesia; Syahrul, F.N., Department of Neurology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Imran, I., Department of Neurology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia, Department of Neurology, Dr. Zainoel Abidin Hospital, Banda Aceh, Aceh, 23111, Indonesia; Haris, S., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Rambe, A.S., Department of Neurology, Faculty of Medicine, Universitas Sumatera Utara, Medan, North Sumatra, 20155, Indonesia; Emran, T.B., Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, 4381, Bangladesh; Rabaan, A.A., Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran, 31311, Saudi Arabia; Tiwari, R., Department of Veterinary Microbiology and Immunology, College of Veterinary Sciences, UP Pandit Deen Upadhayay Pashu Chikitsa Vigyan Vishwavidyalay Evum Go-Anusandhan Sansthan (DUVASU), Mathura, Uttar Pradesh, 281 001, India; Dhama, K., Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, 243122, India; Nainu, F., Faculty of Pharmacy, Hasanuddin University, Makassar, South Sulawesi, 90245, Indonesia; Mutiawati, E., Department of Neurology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia, Department of Neurology, Dr. Zainoel Abidin Hospital, Banda Aceh, Aceh, 23111, Indonesia; Harapan, H., Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia, Department of Microbiology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia, Tropical Disease Centre, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia	Background: In this study, we aimed to determine the global prevalence, chronological order of symptom appearance, and mortality rates with regard to hemorrhagic and ischemic stroke in patients with coronavirus disease 2019 (COVID-19) and to discuss possible pathogeneses of hemorrhagic and ischemic stroke in individuals with the disease. Methods: We searched the PubMed, Scopus, and Web of Science databases for relevant articles published up to November 8, 2020. Data regarding study characteristics, hemorrhagic stroke, ischemic stroke, and COVID-19 were retrieved in accordance with the PRISMA guidelines. The Newcastle-Ottawa scale was used to assess the quality of the eligible studies. The pooled prevalence and mortality rate of hemorrhagic and ischemic stroke were calculated. Results: The pooled estimate of prevalence of hemorrhagic stroke was 0.46% (95% CI 0.40%-0.53%; I 2 =89.81%) among 67,155 COVID-19 patients and that of ischemic stroke was 1.11% (95% CI 1.03%-1.22%; I 2 =94.07%) among 58,104 COVID-19 patients. Ischemic stroke was more predominant (incidence: 71.58%) than hemorrhagic stroke (incidence: 28.42%) in COVID-19 patients who experienced a stroke. In COVID-19 patients who experienced a stroke, hospital admission with respiratory symptoms was more commonly reported than that with neurological symptoms (20.83% for hemorrhagic stroke and 5.51% for ischemic stroke versus 6.94% for hemorrhagic stroke and 5.33% for ischemic stroke, respectively). The pooled mortality rate of COVID-19 patients who experienced a hemorrhagic and ischemic stroke was 44.72% (95% CI 36.73%-52.98%) and 36.23% (95% CI 30.63%-42.24%), respectively. Conclusions: Although the occurrence of hemorrhagic and ischemic stroke is low, the mortality rates of both stroke types in patients with COVID-19 are concerning, and therefore, despite several potential pathogeneses that have been proposed, studies aimed at definitively elucidating the mechanisms of hemorrhagic and ischemic stroke in individuals with COVID-19 are warranted. PROSPERO registration: CRD42020224470 (04/12/20) © 2021 Syahrul S et al.	COVID-19; Haemorrhagic stroke; Ischemic stroke; Meta-analysis; Pathogenesis; SARS-CoV-2; Systematic review	Article; brain hemorrhage; clinical feature; clinical outcome; coronavirus disease 2019; hospital admission; human; incidence; ischemic stroke; meta analysis (topic); mortality rate; neurologic disease; Newcastle-Ottawa scale; pathogenesis; pooled analysis; Preferred Reporting Items for Systematic Reviews and Meta-Analyses; publication bias; respiratory tract disease; risk factor; statistical analysis; symptom; systematic review; brain ischemia; complication; incidence; meta analysis; prospective study; retrospective study; risk factor; Brain Ischemia; COVID-19; Humans; Incidence; Ischemic Stroke; Prospective Studies; Retrospective Studies; Risk Factors	F1000 Research Ltd	20461402	33708378	Article	Q1	1099	3793	View
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749	Victor A.A., Yandandri V.R., Gondowiardjo T.D., Dharma R., Jusman S.W., Prihartono J.	57191055282;57226248415;54956727400;12777817700;36518792100;6602605635;	Effect of laser photocoagulation before vitrectomy to hypoxia inducible factor-1alfa and intracellular adhesive molecule-1 in diabetic patients: A randomized clinical trial	2021	Retina-Vitreus	30	2		204	211		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110980758&doi=10.37845%2fret.vit.2021.30.37&partnerID=40&md5=0facab036ffe38e8aaf9f0feeac57868	Faculty of Medicine, Cipto Mangunkusumo National General Hospital, Ophthalmology, DKI Jakarta, Indonesia; Faculty of Medicine, Clinical Pathology, DKI Jakarta, Jakarta, Indonesia; Faculty of Medicine, Biochemistry Department, Faculty of Medicine, University of Indonesia, DKI Jakarta, Indonesia; Faculty of Medicine, Community Department, Faculty of Medicine, University of Indonesia, DKI Jakarta, Indonesia	Victor, A.A., Faculty of Medicine, Cipto Mangunkusumo National General Hospital, Ophthalmology, DKI Jakarta, Indonesia; Yandandri, V.R., Faculty of Medicine, Cipto Mangunkusumo National General Hospital, Ophthalmology, DKI Jakarta, Indonesia; Gondowiardjo, T.D., Faculty of Medicine, Cipto Mangunkusumo National General Hospital, Ophthalmology, DKI Jakarta, Indonesia; Dharma, R., Faculty of Medicine, Clinical Pathology, DKI Jakarta, Jakarta, Indonesia; Jusman, S.W., Faculty of Medicine, Biochemistry Department, Faculty of Medicine, University of Indonesia, DKI Jakarta, Indonesia; Prihartono, J., Faculty of Medicine, Community Department, Faculty of Medicine, University of Indonesia, DKI Jakarta, Indonesia	Purpose: The vitreous concentration of Hypoxia-inducible Factor-1α (HIF-1α) and Intercellular Adhesive Molecule-1 (ICAM-1) were related to the permeability of retinal vessels and the grades of macular edema in proliferative diabetic retinopathy (PDR). Prior studies have showed that pan-retinal photocoagulation (PRP) is benefi cial in treating PDR. The aim of this study is to determine how pre-treatment with PRP before vitrectomy affect the vitreous level of HIF-1 and ICAM-1 in patients with PDR. Materials and Methods: A randomized clinical trial study was conducted to 22 eyes in Cipto Mangunkusumo National General Hospital, Indonesia. At the beginning of PRP, just before vitrectomy, and at 2, 4, and 12 weeks after vitrectomy, central macular thickness (CMT) was measured using optical coherence tomography (OCT). Undiluted vitreous humour was extracted during vitrectomy to obtain HIF-1α and ICAM-1 concentration. Results: In the control and the photocoagulation group, the average level of HIF-1α (ng/mL) were 0.152±0.015 and 0.164±0.033 respectively. The average level of ICAM-1 (ng/mL) in control group and pre-treated group were 17,840±14,140 and 27,027±10,452 respectively. No statistically signifi cant difference was seen in the level of HIF-1α and ICAM-1 between each group. The correlation between vitreous ICAM- 1 and HbA1c was statistically signifi cant (r=0.463, p=0.03). No signifi cant differences for CMT at pre-vitrectomy, or 2 and 4 weeks after vitrectomy. Statistically signifi cant difference was observed at 12 weeks after follow-up (p=0.049). The correlation between vitreous level of HIF-Iα and CMT in the control and laser group are r = 0.447 and r = 0.32, respectively. Conclusion: Laser photocoagulation 1-2 weeks prior to vitrectomy did not lower vitreous concentration of HIF-1α and ICAM-1. © 2021 Gazi Eye Foundation. All rights reserved.	Diabetic retinopathy; Hypoxia-Inducible Factor 1; Intercellular Adhesion Molecule-1; Light coagulation	hypoxia inducible factor 1alpha; intercellular adhesion molecule 1; adult; Article; cataract; central macular thickness; controlled study; diabetic patient; female; follow up; glaucoma; human; hyphema; laser coagulation; major clinical study; male; middle aged; optical coherence tomography; pars plana vitrectomy; proliferative diabetic retinopathy; randomized controlled trial; retina blood vessel; retina detachment; vitrectomy; vitreous body; vitreous hemorrhage	Gazi Eye Foundation	13001256		Article	Q4	110	28729	View
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48	Wijaya I.P., Karim B., Azizi M.S., Ariyanto I., Mansjoer A., Yunihastuti E., Harimurti K., Alwi I., Lee S., Price P.	57193731572;57192910797;57209578916;57193538110;24335647800;57221273925;23473513200;15055173800;56272877300;57201814264;	Cytomegalovirus may influence vascular endothelial health in Indonesian HIV-infected patients after 5 years on ART	2021	AIDS Research and Therapy	18	1	83				https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119002384&doi=10.1186%2fs12981-021-00410-7&partnerID=40&md5=9b7b4701ffbdd4086f464a8411ac8de3	Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Virology and Cancer Pathobiology Research Centre, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; School of Medicine, Curtin University, Bentley, 6102, Australia	Wijaya, I.P., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Karim, B., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Azizi, M.S., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ariyanto, I., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Virology and Cancer Pathobiology Research Centre, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mansjoer, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Yunihastuti, E., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Harimurti, K., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Alwi, I., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Lee, S., School of Medicine, Curtin University, Bentley, 6102, Australia; Price, P., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, School of Medicine, Curtin University, Bentley, 6102, Australia	Objectives: Accelerated atherosclerosis in older HIV-infected patients has been attributed to persistent immune activation and high burden cytomegalovirus (CMV), as demonstrated in transplant recipients and the general population. Here we assess CMV and inflammatory markers linked with vascular health in young adult patients treated in Indonesia. Study design: HIV-infected adults (n = 32) were examined when they began antiretroviral therapy (ART) with < 200 CD4 T-cells/µl (V0) and after 60 months (V60). Age-matched healthy controls (HC, n = 32) were assessed once. Methods: Flow Mediated Dilatation (FMD) was assessed by ultrasound on brachial arteries at V60 and in HC. Plasma markers of immune activation and endothelial activation, and CMV antibodies (lysate, gB, IE-1) were assessed in all samples. Results were assessed using bivariate (non-parametric) and multivariable analyses. Results: Levels of inflammatory biomarkers and CMV antibodies declined on ART, but the antibodies remained higher than in HC. FMD values were similar in patients and HC at V60. In HIV patients, levels of CMV lysate antibody correlated inversely (r = − 0.37) with FMD. The optimal model predicting lower FMD values (adjusted R2 = 0.214, p = 0.012) included CMV lysate antibodies and chondroitin sulphate. In HC, levels of sTNFR correlated inversely with FMD (r = − 0.41) and remained as a risk factor in the optimal multivariable model, with CMV glycoprotein-B (gB) antibody predicting a healthier FMD (adjusted R2 = 0.248, p = 0.013). Conclusions: Higher levels CMV antibodies optimally predict vascular health measured by FMD in HIV patients. However in healthy controls, sTNFR marks risk and CMV gB antibody may be protective. © 2021, The Author(s).	CMV; Endothelial function; HIV; Inflammatory biomarkers	virus antibody; aged; Cytomegalovirus; cytomegalovirus infection; human; Human immunodeficiency virus infection; Indonesia; Aged; Antibodies, Viral; Cytomegalovirus; Cytomegalovirus Infections; HIV Infections; Humans; Indonesia	BioMed Central Ltd	17426405	34763708	Article	Q1	1102	3778	View
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645	Kusmardi K., Azzahra Baihaqi L., Estuningtyas A., Sahar N., Sunaryo H., Tedjo A.	56966625300;57383198200;55650360200;57212464367;57214674652;57189320451;	Ethanol Extract of Pomegranate (Punica granatum) Peel in Increasing the Expression of Caspase-3 in DSS-Induced Mice	2021	International Journal of Inflammation	2021		4919410				https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121616606&doi=10.1155%2f2021%2f4919410&partnerID=40&md5=f0575e8e8aafbe4434f9cad30aeabaca	Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Drug Development Research Center (DDRC Cluster, IMERI, Faculty of Medicine), Jakarta, Indonesia; Human Cancer Research Center (HCRC Cluster, IMERI, Faculty of Medicine), Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Department of Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. HAMKA, Jakarta, Indonesia; Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia	Kusmardi, K., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia, Drug Development Research Center (DDRC Cluster, IMERI, Faculty of Medicine), Jakarta, Indonesia, Human Cancer Research Center (HCRC Cluster, IMERI, Faculty of Medicine), Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Azzahra Baihaqi, L., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Estuningtyas, A., Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Sahar, N., Department of Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Sunaryo, H., Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. HAMKA, Jakarta, Indonesia; Tedjo, A., Drug Development Research Center (DDRC Cluster, IMERI, Faculty of Medicine), Jakarta, Indonesia, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia	Background. Colorectal cancer (CRC) is a malignancy derived from the glandular epithelial cells in the colon. Patients with inflammatory bowel disease (IBD) are more likely to develop CRC. Cancer proliferation is characterized by the loss of inhibition of apoptosis, which involves caspase-3 activation. This study examined the effects of the pomegranate peel extract on the expression of caspase-3 in mice crypt cells induced by dextran sodium sulfate (DSS) 2%. Methods. The experimental study was done in six groups. All treatments were done in 42 days. The groups were all induced by DSS through water drinking, except for the normal group, which was only given water. The treatments given included the pomegranate extract in two doses (240 mg and 480 mg/kg bw/day), aspirin, and ellagic acid. The specimens were then fixated and stained for the immunohistochemistry scoring for the expression of caspase-3, which was then analyzed statistically. Results. The H-scores of each treatment group were 213.23 ± 8.32 (DSS group), 243.81 ± 18.69 (normal group), 226.10 ± 12.38 (pomegranate peel extract of 240 mg/kg/d), 238.84 ± 15.81 (pomegranate peel extract of 480 mg/kg/d), 227.47 ± 12.15 (aspirin), and 224.01 ± 18.39 (ellagic acid). Statistical differences were found in one-way analysis of variance (ANOVA) and post hoc analysis among the DSS group, normal group, and dose 2 group (pomegranate peel extract of 480 mg/kg/day). Conclusions. The ethanol extract of pomegranate was able to induce apoptosis, which was demonstrated by the increase of caspase-3 expression. © 2021 Kusmardi Kusmardi et al.			Hindawi Limited	20908040		Article	Q2	1106	3761	View

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