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Safari D., Gultom S.M., Tafroji W., Azzahidah A., Soesanti F., Khoeri M.M., Prayitno A., Pimenta F.C., da Gloria Carvalho M., Uiterwaal C.S.P.M., Putri N.D. |
23493586700;57223995277;57118271600;57223997121;37068080600;55994827400;57193342301;6603696480;55189494500;7006033434;57200573842; |
Prevalence, serotype and antibiotic susceptibility of Group B Streptococcus isolated from pregnant women in Jakarta, Indonesia |
2021 |
PLoS ONE |
16 |
5 May |
e0252328 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106668508&doi=10.1371%2fjournal.pone.0252328&partnerID=40&md5=d5ae48dcce9738619d131a8193789686 |
Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Faculty of Medicine, Department of Child Health, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Aix-Marseille University, Marseille, France; Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States; Julius Center for Health Sciences and Primary Care, Julius Global Health, University Medical Center, Utrecht, Netherlands |
Safari, D., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Gultom, S.M., Faculty of Medicine, Department of Child Health, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Tafroji, W., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Azzahidah, A., Aix-Marseille University, Marseille, France; Soesanti, F., Faculty of Medicine, Department of Child Health, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Khoeri, M.M., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Prayitno, A., Faculty of Medicine, Department of Child Health, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Pimenta, F.C., Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States; da Gloria Carvalho, M., Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States; Uiterwaal, C.S.P.M., Julius Center for Health Sciences and Primary Care, Julius Global Health, University Medical Center, Utrecht, Netherlands; Putri, N.D., Faculty of Medicine, Department of Child Health, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Group B Streptococcus (GBS) is a bacterial pathogen which is a leading cause of neonatal infection. Currently, there are limited GBS data available from the Indonesian population. In this study, GBS colonization, serotype distribution and antimicrobial susceptibility profile of isolates were investigated among pregnant women in Jakarta, Indonesia. Demographics data, clinical characteristics and vaginal swabs were collected from 177 pregnant women (mean aged: 28.7 years old) at 29–40 weeks of gestation. Bacterial culture identification tests and latex agglutination were performed for GBS. Serotyping was done by conventional multiplex PCR and antibiotic susceptibility testing by broth microdilution. GBS colonization was found in 53 (30%) pregnant women. Serotype II was the most common serotype (30%) followed by serotype III (23%), Ia and IV (13% each), VI (8%), Ib and V (6% each), and one non-typeable strain. All isolates were susceptible to vancomycin, penicillin, ampicillin, cefotaxime, daptomycin and linezolid. The majority of GBS were resistant to tetracycline (89%) followed by clindamycin (21%), erythromycin (19%), and levofloxacin (6%). The serotype III was more resistant to erythromycin, clindamycin, and levofloxacin and these isolates were more likely to be multidrug resistant (6 out of 10) compared to other serotypes. This report provides demographics of GBS colonization and isolate characterization in pregnant women in Indonesia. The results may facilitate preventive strategies to reduce neonatal GBS infection and improve its treatment. Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. |
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ampicillin; cefotaxime; cefoxitin; ceftizoxime; ciprofloxacin; clindamycin; daptomycin; erythromycin; levofloxacin; linezolid; penicillin derivative; tetracycline; vancomycin; adolescent; adult; antibiotic resistance; antibiotic sensitivity; Article; bacterial colonization; bacterium culture; bacterium identification; bacterium isolate; broth dilution; controlled study; female; gestation period; group B streptococcal infection; human; Indonesia; latex agglutination test; major clinical study; multidrug resistance; multiplex polymerase chain reaction; nonhuman; pregnancy; prevalence; serotype; Streptococcus agalactiae; vagina smear; antibiotic resistance; isolation and purification; pregnancy; pregnancy complication; Streptococcus agalactiae; Streptococcus infection; young adult; Adolescent |
Public Library of Science |
19326203 |
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34043711 |
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407 |
Atmoko W., Raharja P.A.R., Birowo P., Ardy A.R., Hamid H., Taher A., Rasyid N. |
57193125664;57201013616;6504153311;57223308079;57223278890;7005269743;56245069300; |
Genetic polymorphisms as prognostic factors for recurrent kidney stones: A systematic review and meta-analysis |
2021 |
PLoS ONE |
16 |
5 May |
e0251235 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105518414&doi=10.1371%2fjournal.pone.0251235&partnerID=40&md5=b6950d085d520fd3088636a18669e525 |
Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Atmoko, W., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Raharja, P.A.R., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Birowo, P., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ardy, A.R., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hamid, H., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Taher, A., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rasyid, N., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Genetic polymorphisms have been suggested as risk factors affecting the occurrence and recurrence of kidney stones, although findings regarding the latter remain inconclusive. We performed this systematic review and meta-analysis to clarify the associations between genetic polymorphisms and recurrent kidney stones. PubMed, SCOPUS, EMBASE, and Cochrane Library databases were searched through May 28th, 2020 to identify eligible studies. The Quality in prognostic studies (QUIPS) tool was used to evaluate bias risk. Allelic frequencies and different inheritance models were assessed. All analyses were performed using Review manager 5.4. A total of 14 studies were included for meta-analysis, assessing urokinase (ApaL1) and vitamin D receptor (VDR) (ApaI, BsmI, FokI, and TaqI) gene polymorphisms. The ApaLI polymorphism demonstrated protective association in the recessive model [odds ratio (OR) 0.45, P < 0.01] albeit higher risk among Caucasians in the heterozygous model (OR 16.03, P < 0.01). The VDR-ApaI polymorphism showed protective association in the dominant model (OR 0.60, P < 0.01). Among Asians, the VDR-FokI polymorphism recessive model showed significant positive association (OR 1.70, P < 0.01) and the VDR-TaqI polymorphism heterozygous model exhibited protective association (OR 0.72, P < 0.01). The VDR-BsmI polymorphism was not significantly associated with recurrent kidney stones in any model. Urokinase-ApaLI (recessive model), VDR-ApaI (dominant model), and VDR-TaqI (heterozygous model) polymorphisms were associated with decreased recurrent kidney stone risk whereas urokinase-ApaLI (heterozygous model) and VDR-FokI polymorphisms were associated with increased risk among Caucasians and Asians, respectively. These findings will assist in identifying individuals at risk of kidney stone recurrence. © 2021 Atmoko et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author andsource are credited. |
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urokinase; vitamin D receptor; ApaL1 gene; Asian; Caucasian; dominant inheritance; gene frequency; genetic association; genetic polymorphism; genetic variability; heterozygosity; high risk patient; human; nephrolithiasis; prognosis; protection; recessive inheritance; recurrence risk; Review; risk reduction; systematic review; VDR gene; genetic polymorphism; genetics; meta analysis; nephrolithiasis; prognosis; recurrent disease; Humans; Kidney Calculi; Polymorphism, Genetic; Prognosis; Recurrence |
Public Library of Science |
19326203 |
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33956883 |
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468 |
Prasetyo M., Moniqa R., Tulaar A., Prihartono J., Setiawan S.I. |
57192905252;57221866634;24330360800;6602605635;57195939543; |
Correlation between Hemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) score and Hemophilia Joint Health Score (HJHS) in patients with hemophilic arthropathy |
2021 |
PLoS ONE |
16 |
4 April |
e0248952 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103995985&doi=10.1371%2fjournal.pone.0248952&partnerID=40&md5=33018f7adcb5c975c29264deba385db3 |
Department of Radiology, Faculty of Medicine Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Department of Medical Rehabilitation, Faculty of Medicine Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Prasetyo, M., Department of Radiology, Faculty of Medicine Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Moniqa, R., Department of Radiology, Faculty of Medicine Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Tulaar, A., Department of Medical Rehabilitation, Faculty of Medicine Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Prihartono, J., Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Setiawan, S.I., Department of Radiology, Faculty of Medicine Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia |
Background Hemophilic arthropathy, a condition manifested as joint destruction due to spontaneous joint bleeding, is one complication of hemophiliac patients. Early detection and intervention may improve the outcome, in which ultrasonography can be an ideal modality with the introduction of HEAD-US (Hemophilia Early Arthropathy Detection with Ultrasound) protocol. Studies have shown US benefit in hemophiliac patients, including its potential as an alternative for the Hemophiliac Joint Health Score (HJHS) system. However, many of the studies were conducted in countries with better management of hemophilia using prophylaxis treatment. It is unclear whether HEAD-US has a correlation with HJHS in countries using episodic treatment only, like in Indonesia. Purpose This study aimed to explore the correlation between HEAD-US and HJHS in hemophiliac patients with joint problems in Indonesia. Materials and methods A cross-sectional correlation study between HEAD-US and HJHS was performed with primary data collected from 120 hemophilic patients. US examination was performed on elbow, knee and ankle joints using the HEAD-US scoring method by a musculoskeletal radiologist. HJHS examination was conducted by a trained physiotherapist and a medical rehabilitation specialist. All examiner is member of multidisciplinary Hemophiliac Management Team in Cipto Mangunkusumo General Hospital in Jakarta, Indonesia. Results The mean age of the participant was 9.3 (5-14) years old. The median score of HEAD-US was 8 (1-28) with most of the joint abnormalities found on the ankles. The median score of HJHS was 3 (0-35), with most joint abnormalities found on the knees. There was a moderate correlation between HEAD-US and HJHS score (p < 0.05, r = 0.65). Conclusion HEAD-US shows a moderate correlation to HJHS in hemophiliac patients who received episodic treatment. HEAD-US can provide additional value in the anatomical evaluation of the joint and could be complementary to HJHS in assessing the joint status in hemophilic patient. © 2021 Prasetyo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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adolescent; ankle; Article; child; controlled study; correlational study; cross-sectional study; disease assessment; echography; elbow; Hemophilia Early Arthropathy Detection with Ultrasound score; Hemophilia Joint Health Score; hemophilic arthropathy; human; Indonesia; information processing; knee; major clinical study; medical specialist; musculoskeletal radiologist; physiotherapist; scoring system; arthropathy; diagnostic imaging; early diagnosis; echography; hemophilia A; joint; pathology; preschool child; procedures; Adolescent; Child; Child, Preschool; Cross-Sectional Studies; Early Diagnosis; Hemophilia A; Humans; Indonesia; Joint Diseases; Joints; Ultrasonography |
Public Library of Science |
19326203 |
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33826621 |
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990 |
4434 |
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531 |
Lazarus G., Tjoa K., Iskandar A.W.B., Louisa M., Sagwa E.L., Padayatchi N., Soetikno V. |
57214599425;57222366705;57217632802;41461551400;53464303100;6603387290;36769252100; |
The effect of human immunodeficiency virus infection on adverse events during treatment of drug-resistant tuberculosis: A systematic review and meta-analysis |
2021 |
PLoS ONE |
16 |
3 March |
e0248017 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102483457&doi=10.1371%2fjournal.pone.0248017&partnerID=40&md5=e604a5ae346e4c3a4b38a5f906459a26 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Windhoek, Namibia; Nairobi, Kenya; CAPRISA MRC-HIV-TB Pathogenesis and Treatment Research Unit, Durban, South Africa |
Lazarus, G., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tjoa, K., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Iskandar, A.W.B., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sagwa, E.L., Windhoek, Namibia, Nairobi, Kenya; Padayatchi, N., CAPRISA MRC-HIV-TB Pathogenesis and Treatment Research Unit, Durban, South Africa; Soetikno, V., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background Adverse events (AEs) during drug-resistant tuberculosis (DR-TB) treatment, especially with human immunodeficiency virus (HIV) co-infection, remains a major threat to poor DR-TB treatment adherence and outcomes. This meta-analysis aims to investigate the effect of HIV infection on the development of AEs during DR-TB treatment. Methods Eligible studies evaluating the association between HIV seropositivity and risks of AE occurrence in DR-TB patients were included in this systematic review. Interventional and observational studies were assessed for risk of bias using the Risk of Bias in Nonrandomized Studies of Intervention and Newcastle-Ottawa Scale tool, respectively. Random-effects meta-analysis was performed to estimate the pooled risk ratio (RR) along with their 95% confidence intervals (CIs). Results A total of 37 studies involving 8657 patients were included in this systematic review. We discovered that HIV infection independently increased the risk of developing AEs in DR-TB patients by 12% (RR 1.12 [95% CI: 1.02-1.22]; I2 = 0%, p = 0.75). In particular, the risks were more accentuated in the development of hearing loss (RR 1.44 [95% CI: 1.18-1.75]; I2 = 60%), nephrotoxicity (RR 2.45 [95% CI: 1.20-4.98], I2 = 0%), and depression (RR 3.53 [95% CI: 1.38-9.03]; I2 = 0%). Although our findings indicated that the augmented risk was primarily driven by antiretroviral drug usage rather than HIV-related immunosuppression, further studies investigating their independent effects are required to confirm our findings. Conclusion HIV co-infection independently increased the risk of developing AEs during DR-TB treatment. Increased pharmacovigilance through routine assessments of audiological, renal, and mental functions are strongly encouraged to enable prompt diagnosis and treatment in patients experiencing AEs during concomitant DR-TB and HIV treatment. Copyright: © 2021 Lazarus et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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antiretrovirus agent; efavirenz; ethionamide; kanamycin; lamivudine; pyrazinamide; tenofovir; tuberculostatic agent; tuberculostatic agent; adverse event; antiretroviral therapy; coinfection; confidence interval; data analysis; data extraction; data quality assessment; depression; drug resistant tuberculosis; hearing impairment; human; Human immunodeficiency virus infection; immune deficiency; meta analysis; nephrotoxicity; Newcastle-Ottawa scale; Review; statistical analysis; systematic review; adverse drug reaction; complication; depression; hearing impairment; Human immunodeficiency virus infection; kidney failure; multidrug resistant tuberculosis; Antitubercular Agents; Depression; Drug-Related Side Effects and Adverse Reactions; Hearing Loss; HIV Infections; Humans; Renal Insufficienc |
Public Library of Science |
19326203 |
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33662024 |
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990 |
4434 |
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577 |
Hayuningtyas A., Dewi Y.A., Octavia L., Pulungan A., Agustina R. |
57221416876;57221416331;57205693397;57192905981;57214141404; |
Dietary quality score is positively associated with serum adiponectin level in Indonesian preschool-Age children living in the urban area of Jakarta |
2021 |
PLoS ONE |
16 |
2 February 2021 |
e0246234 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100556583&doi=10.1371%2fjournal.pone.0246234&partnerID=40&md5=96542590163d73f573030ac70b15220c |
Department of Nutrition, Faculty of Medicine, Universitas Indonesia Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Child Health, Faculty of Medicine, Universitas Indonesia Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Human Nutrition Research Centre, Indonesia Medical Education and Research Institute Indonesia, Faculty of Medicine, Jakarta, Indonesia |
Hayuningtyas, A., Department of Nutrition, Faculty of Medicine, Universitas Indonesia Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Dewi, Y.A., Department of Nutrition, Faculty of Medicine, Universitas Indonesia Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Octavia, L., Department of Nutrition, Faculty of Medicine, Universitas Indonesia Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Pulungan, A., Department of Child Health, Faculty of Medicine, Universitas Indonesia Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Agustina, R., Department of Nutrition, Faculty of Medicine, Universitas Indonesia Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Nutrition Research Centre, Indonesia Medical Education and Research Institute Indonesia, Faculty of Medicine, Jakarta, Indonesia |
An unhealthy diet during childhood directly impacts the risk of developing noncommunicable diseases (NCDs) later on in life. However, well-documented information on this issue is lacking. We investigated the dietary quality of young Indonesian children and assessed the relationship to serum adiponectin levels as an early marker of NCDs. Eighty-five (44 girls and 41 boys) Indonesian preschool-Age children in East Jakarta were included in this study. Dietary intake data were gathered by collecting repeated 24-hour recalls for one weekday and one day during the weekend, which were then further converted into participants Healthy Eating Index (HEI) 2015 scores. Meanwhile, an enzyme-linked immunosorbent assay was performed to determine the serum adiponectin level. A multiple regression analysis was performed to assess the association between the HEI 2015 score and serum adiponectin, adjusting for potential confounders. The mean HEI 2015 score was 33.2 ± 8.3 points, which was far below the recommended score of ≤80 points, while the mean serum adiponectin was 10.3 ± 4.1 μg/mL. Multiple linear regression testing showed that a one-point increase in the HEI 2015 score was significantly associated with an increase in the serum adiponectin level by 0.115 μg/mL after adjusting for exclusive breastfeeding history (β = 0.115; 95% CI = 0.010 0.221; p = 0.032). In conclusion, better adherence of young children to a healthy diet has a positive association with their adiponectin level. This result suggests that strengthening children s dietary quality from an early age by involving all parties in the children s environment (e.g., parents, teachers at school, policymakers) may help to reduce the risk of NCDs later on in childhood and during adult life. © 2021 Public Library of Science. All rights reserved. |
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adiponectin; ADIPOQ protein, human; blood; clinical trial; cross-sectional study; female; human; Indonesia; male; preschool child; statistical model; urban population; Adiponectin; Child, Preschool; Cross-Sectional Studies; Diet, Healthy; Female; Humans; Indonesia; Linear Models; Male; Urban Population |
Public Library of Science |
19326203 |
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33539478 |
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990 |
4434 |
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578 |
Arguni E., Karyanti M.R., Satari H.I., Hadinegoro S.R. |
8520598700;56290680800;57226214366;56893685800; |
Diphtheria outbreak in Jakarta and Tangerang, Indonesia: Epidemiological and clinical predictor factors for death |
2021 |
PLoS ONE |
16 |
2 February |
e0246301 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100508974&doi=10.1371%2fjournal.pone.0246301&partnerID=40&md5=d5c31533e8d632bb7459927c7da0cce2 |
Department of Child Health, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Department of Pediatric, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Arguni, E., Department of Child Health, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Karyanti, M.R., Department of Pediatric, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Satari, H.I., Department of Pediatric, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Hadinegoro, S.R., Department of Pediatric, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Background In 2017, a diphtheria outbreak occurred in several provinces in Indonesia. The aim of this study was to identify predictors of mortality outcome of pediatric patients with clinical diphtheria. Methods A retrospective cohort study was conducted using patient medical records at five referral hospitals in the Province of Jakarta and one in Tangerang District, Banten Province during January 2017 to 31 August 2018. All children in the age group of 1-18 years old discharged with diagnosis of clinical diphtheria formed the study group. All anonymized patient data were evaluated for demographic issues, clinical features, immunization status, complication, laboratory profiles and outcome. Results A total of 283 patients with clinical diphtheria were included in the study group with case fatality rate of 3.5%. All mortal patients had the complication of myocarditis. Regression analyses revealed factors for predicting mortality. Incomplete primary diphtheria toxoid immunization, stridor, bull neck, leukocytosis ≥15 ×109 cells/L and thrombocytopenia ≤150 x109 cells/L in each combination for 2 predictors modeling were correlated with death. Conclusions We report key predictors of mortality in pediatric patients with clinical diphtheria. The presence of these features when admitted to the hospital must be taken into account, because they can lead to fatal outcome. © 2021 Arguni et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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adolescent; child; cohort analysis; complication; diphtheria; epidemic; female; hospitalization; human; immunization; Indonesia; infant; male; medical record; mortality; myocarditis; preschool child; regression analysis; retrospective study; vaccination; Adolescent; Child; Child, Preschool; Cohort Studies; Diphtheria; Disease Outbreaks; Female; Hospitalization; Humans; Immunization; Indonesia; Infant; Male; Medical Records; Myocarditis; Regression Analysis; Retrospective Studies; Vaccination |
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19326203 |
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33539453 |
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4434 |
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883 |
Harimurti K., Saldi S.R.F., Dewiasty E., Alfarizi T., Dharmayuli M., Khoeri M.M., Paramaiswari W.T., Salsabila K., Tafroji W., Halim C., Jiang Q., Gamil A., Safari D. |
23473513200;55201904000;55257705500;57221853325;57221841113;55994827400;57221097580;57192272141;57118271600;57221850899;36028184700;57202388319;23493586700; |
Streptococcus pneumoniae carriage and antibiotic susceptibility among Indonesian pilgrims during the Hajj pilgrimage in 2015 |
2021 |
PLoS ONE |
16 |
1 January |
e0246122 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100423019&doi=10.1371%2fjournal.pone.0246122&partnerID=40&md5=49970f6f2918134dc220f4fd13977bed |
Clinical Epidemiology and Evidence-Based Medicine (CEEBM) Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Center of Hajj Health, Ministry of Health, Jakarta, Indonesia; Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Pfizer Indonesia, Jakarta, Indonesia; Pfizer Inc., Collegeville, PA, United States; Pfizer Inc., Emerging Markets Medical and Scientific Affairs, Dubai, United Arab Emirates |
Harimurti, K., Clinical Epidemiology and Evidence-Based Medicine (CEEBM) Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Saldi, S.R.F., Clinical Epidemiology and Evidence-Based Medicine (CEEBM) Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Dewiasty, E., Clinical Epidemiology and Evidence-Based Medicine (CEEBM) Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Alfarizi, T., Center of Hajj Health, Ministry of Health, Jakarta, Indonesia; Dharmayuli, M., Center of Hajj Health, Ministry of Health, Jakarta, Indonesia; Khoeri, M.M., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Paramaiswari, W.T., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Salsabila, K., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Tafroji, W., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Halim, C., Pfizer Indonesia, Jakarta, Indonesia; Jiang, Q., Pfizer Inc., Collegeville, PA, United States; Gamil, A., Pfizer Inc., Emerging Markets Medical and Scientific Affairs, Dubai, United Arab Emirates; Safari, D., Eijkman Institute for Molecular Biology, Jakarta, Indonesia |
The Hajj is an annual pilgrimage to Mecca and one of the largest gathering of people in the world. Most Indonesian pilgrims are senior adults and elderly adults, who are more prone to acquire infections during the Hajj ritual. The aims of this study are to investigate the dynamics of Streptococcus pneumoniae colonization and to investigate antibiotic susceptibility of pneumococcal strains in Indonesian pilgrims. This was a prospective multi-site longitudinal study in Indonesian hajj pilgrims aged >18 years old in the year 2015. Nasopharyngeal swabs were collected from the same subject before departure and upon arrival at the airport. S. pneumoniae was identified using conventional and molecular approach, while antibiotic susceptibility was determined using a disk diffusion method. Among 813 Hajj pilgrims who were enrolled from five sites in this study, the prevalence of S. pneumoniae carriage rates before- and after-the Hajj were 8.6% (95% CI 6.7–10.5%) and 8.2% (95% CI 6.4–10.1%), (p value: 0.844) respectively. Serotype 16F, 6A/6B, 3, 18, and 23F were the five most prevalent serotypes before Hajj, whereas serotypes 3, 34, 13, 4, and 23F were the most prevalent serotypes after Hajj. Serotype 3 was identified as most acquired serotype during Hajj in Indonesian pilgrim. There was an increase in the percentage of isolates susceptible to co-trimoxazole after Hajj (42.9% versus 57.4%). The study provided an overview of the change of dynamics of S. pneumoniae serotype acquisition in Indonesian Hajj Pilgrims. Along with data of vaccination serotypes coverage and antimicrobial susceptibility, these findings may contribute to recommendation of vaccination and treatment policies in the future. © 2021 Harimurti et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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chloramphenicol; clindamycin; cotrimoxazole; erythromycin; penicillin derivative; tetracycline; antiinfective agent; adult; airport; antibiotic sensitivity; Article; bacterial colonization; bacterial strain; bacterium isolate; controlled study; disk diffusion; female; human; Indonesian; longitudinal study; male; nasopharyngeal swab; nonhuman; prospective study; serotype; Streptococcus pneumoniae; adolescent; antibiotic resistance; clinical trial; crowding (area); growth, development and aging; heterozygote; Indonesia; isolation and purification; microbial sensitivity test; microbiology; middle aged; multicenter study; nasopharynx; pneumococcal infection; Streptococcus pneumoniae; Adolescent; Adult; Anti-Bacterial Agents; Carrier State; Crowding; Drug Resistance, Bacterial; Female; Humans; |
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19326203 |
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33497410 |
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885 |
Prayitno A., Supriyatno B., Munasir Z., Karuniawati A., Hadinegoro S.R.S., Prihartono J., Safari D., Sundoro J., Khoeri M.M. |
57193342301;37068046400;7801694370;54886816200;57226218772;6602605635;23493586700;49762130000;55994827400; |
Pneumococcal nasopharyngeal carriage in Indonesia infants and toddlers post-PCV13 vaccination in a 2+1 schedule: A prospective cohort study |
2021 |
PLoS ONE |
16 |
1 January |
e0245789 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100392996&doi=10.1371%2fjournal.pone.0245789&partnerID=40&md5=cb78eb658b86a8f3be7a35fe8b7fd3cc |
Department of Pediatrics, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Microbiology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Molecular Bacteriology, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Indonesian Technical Advisory Group on Immunization, Jakarta, Indonesia |
Prayitno, A., Department of Pediatrics, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Supriyatno, B., Department of Pediatrics, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Munasir, Z., Department of Pediatrics, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Karuniawati, A., Department of Microbiology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Hadinegoro, S.R.S., Department of Pediatrics, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Prihartono, J., Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Safari, D., Molecular Bacteriology, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Sundoro, J., Indonesian Technical Advisory Group on Immunization, Jakarta, Indonesia; Khoeri, M.M., Molecular Bacteriology, Eijkman Institute for Molecular Biology, Jakarta, Indonesia |
Background The PCV13 immunization demonstration program began in October 2017 in Indonesia. The aim of this study is to assess the dynamic changes of pneumococcal serotype before and after PCV13 administration, with two primary and one booster doses. Methods The prospective cohort study was conducted as a follow up study measuring the impact of PCV13 demonstration program by the Indonesian Ministry of Health in Lombok Island, West Nusa Tenggara, Indonesia, from March 2018 to June 2019. The subjects were two-month-old healthy infants who were brought to the primary care facility for routine vaccination and followed until 18 months of age. We use convenience sampling method. There were 115 infants in the control group and 118 infants in the vaccine group, and the PCV immunization was given on a 2+1 schedule. Nasopharyngeal (NP) swabs were collected four times during the vaccination periods by trained medical staff. Specimens were analyzed by culture methods to detect S. pneumonia colonization and multiplex polymerase chain reaction (mPCR) to determine serotype. The most frequently detected serotypes will be named as dominant serotypes. Descriptive analysis of demographic characteristics, the prevalence of overall and serotype colonization, and the distribution of serotypes were performed. The prevalence of both cohort groups were compared using chi-square test. Statistical significance was set at p < 0.05. Results Two hundred and thirty three infants age two months old were recruited, with 48.9% of the subjects were male and 51.1% of the subjects were female. Sociodemographic data in both cohort groups were relatively equal. Nasopharyngeal pneumococcal colonization before PCV13 administration occurred in 19.1% of the control and 22.9% of the vaccine group. The prevalence increased with increasing age in both groups. The prevalence of VT serotypes in control groups aged 2 months, 4 months, 12 months, and 18 months was 40.9%, 44.2%, 53.8%, and 54.3%, respectively, and in the vaccine group, 25.9%, 40.4%, 38.0%, and 22.6%, respectively. The most common VT serotypes in both groups were 6A/6B, 19F, 23F, and 14. The prevalence of VT serotypes decreased significantly compared to non-vaccine type serotypes after three doses of the PCV13 vaccine (p < 0.001). Another notable change was the decline in prevalence of serotype 6A/6B after PCV13 administration using the 2+1 schedule. Conclusions This study shows lower prevalence of VT and 6A/6B serotypes in the nasopharynx among children who were PCV13 vaccinated compared with those who were unvaccinated. The result from this study will be the beginning of future vaccine evaluation in larger population and longer period of study. © 2021 Prayitno et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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Pneumococcus vaccine; 13-valent pneumococcal vaccine; Pneumococcus vaccine; Article; bacterial colonization; bacterium carrier; cohort analysis; controlled study; demography; female; follow up; human; human experiment; Indonesia; infant; male; multiplex polymerase chain reaction; nasopharynx; normal human; population research; prevalence; primary medical care; serotype; sex ratio; social status; Streptococcus pneumoniae; toddler; trend study; vaccination; immunology; isolation and purification; microbiology; nose mucosa; pathogenicity; pneumococcal infection; preschool child; procedures; Streptococcus pneumoniae; Child, Preschool; Female; Humans; Indonesia; Infant; Male; Nasal Mucosa; Pneumococcal Infections; Pneumococcal Vaccines; Streptococcus pneumoniae; Vaccination |
Public Library of Science |
19326203 |
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33497405 |
Article |
Q1 |
990 |
4434 |
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888 |
Subekti I., Kartiko G.J., Suhardi Z.F., Muhadi, Wisnu W. |
24336854300;57221818935;57221814580;57189615533;57200425452; |
Serum TSH level as predictor of Graves' disease recurrence following antithyroid drug withdrawal: A systematic review |
2021 |
PLoS ONE |
16 |
1 January |
e0245978 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100298149&doi=10.1371%2fjournal.pone.0245978&partnerID=40&md5=68971152ed2933aff2d374d62012a231 |
Faculty of Medicine, Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Division of Cardiology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia |
Subekti, I., Faculty of Medicine, Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Kartiko, G.J., Faculty of Medicine, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Suhardi, Z.F., Faculty of Medicine, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Muhadi, Faculty of Medicine, Division of Cardiology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Wisnu, W., Faculty of Medicine, Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia |
Graves' disease (GD) has a high recurrence rate despite various and adequate treatment. Numerous studies have been performed to identify the predictor of disease recurrence. This report aims to investigate the role of thyroid stimulating hormone (TSH) level as a thyrotropin in predicting the recurrence of Graves' disease within 1 to 2 years following antithyroid drug (ATD) withdrawal. Literature searching was conducted on PubMed, Scopus, Cochrane, Proquest, EBSCO in August 2019 and Google Scholar in October 2020. The study criteria include the study that evaluates TSH level 4 weeks following ATD withdrawal, with subjects ≥18 years old who are retrospectively or prospectively followed up after 1 to 2 years following ATD withdrawal. Four eligible studies were selected based on inclusion/exclusion criteria, all of which measured TSH level at 4 weeks following ATD withdrawal. All studies had 1 to 2 years follow up. One study was an RCT, two studies were done in prospective cohort and another in retrospective cohort. All studies had comparable validity and applicability. Three out of four studies suggested that low TSH level measured 4 weeks following treatment withdrawal was associated with higher risk of disease recurrence. In conclusion, low TSH level obtained 4 weeks after ATD withdrawal was associated with higher rate of recurrence rate in GD. Copyright: © 2021 Subekti et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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antithyroid agent; thyrotropin; antithyroid agent; thyrotropin; Article; clinical evaluation; clinical outcome; disease association; drug withdrawal; follow up; Graves disease; human; prospective study; recurrence risk; recurrent disease; risk factor; systematic review; thyrotropin blood level; blood; Graves disease; recurrent disease; treatment withdrawal; Antithyroid Agents; Graves Disease; Humans; Recurrence; Thyrotropin; Withholding Treatment |
Public Library of Science |
19326203 |
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33513181 |
Article |
Q1 |
990 |
4434 |
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