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Liberty I.A., Kodim N., Sartika R.A.D., Trihandini I., Tjekyan R.M.S., Zulkarnain, Pane M., Pratisthita L.B., Tahapary D.L., Soewondo P. |
57211435130;57210444174;41862490800;8449988100;57267287700;57267073300;55831164800;57221504201;55944492500;23475336100; |
Triglyceride/Glucose Index (TyG Index) as a marker of glucose status conversion among reproductive-aged women in Jakarta, Indonesia: The Bogor cohort study (2011–2016) |
2021 |
Diabetes and Metabolic Syndrome: Clinical Research and Reviews |
15 |
6 |
102280 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115349587&doi=10.1016%2fj.dsx.2021.102280&partnerID=40&md5=db55d7f5dcad157ad5a355acd19a0c89 |
Department of Public Health and Community Medicine, University of Sriwijaya, Indonesia; Department of Epidemiology, Public Health Faculty, Universitas Indonesia, Depok, Indonesia; Department of Public Nutrition, Public Health Faculty Universitas Indonesia, Depok, Indonesia; Department of Biostatistics, Public Health Faculty Universitas Indonesia, Depok, Indonesia; National Institute Health Research and Development, Ministry of Health of the Republic of Indonesia, Indonesia; Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Universitas Indonesia Hospital, Depok, Indonesia; Division of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Liberty, I.A., Department of Public Health and Community Medicine, University of Sriwijaya, Indonesia, Department of Epidemiology, Public Health Faculty, Universitas Indonesia, Depok, Indonesia; Kodim, N., Department of Epidemiology, Public Health Faculty, Universitas Indonesia, Depok, Indonesia; Sartika, R.A.D., Department of Public Nutrition, Public Health Faculty Universitas Indonesia, Depok, Indonesia; Trihandini, I., Department of Biostatistics, Public Health Faculty Universitas Indonesia, Depok, Indonesia; Tjekyan, R.M.S., Department of Public Health and Community Medicine, University of Sriwijaya, Indonesia; Zulkarnain, Department of Public Health and Community Medicine, University of Sriwijaya, Indonesia; Pane, M., National Institute Health Research and Development, Ministry of Health of the Republic of Indonesia, Indonesia; Pratisthita, L.B., Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Internal Medicine, Universitas Indonesia Hospital, Depok, Indonesia; Tahapary, D.L., Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Division of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Soewondo, P., Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Division of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background and aims: Reproductive-aged women are prone to type 2 diabetes mellitus. This study aims to evaluate the optimal cut off point of Triglyceride/Glucose Index for predicting glucose status conversion among women of reproductive age. Methods: This study involved normoglycemic and prediabetes women aged 20–49 years from the Bogor Non-Communicable Diseases Cohort Study (West Java, Indonesia) conducted from 2011 to 2016. Statistical analysis was performed using Receiver Operating Characteristics curve analysis with STATA version 15. Results: Among prediabetes subjects (n = 371), the cut-off point of TyG index for regression from prediabetes to normoglycemic subjects was <4.51 [sensitivity, specificity, AUC (95%CI) 83.9%, 80.1%, 0.913 (0.875–0.943), respectively] and the cut-off point for progression from prediabetes to diabetes was >4.54 [80.0%, 73.1%, 0.858 (0.807–0.900)]. Among normoglycemic subjects (n = 1300), the cut-off point of TyG index for progression to prediabetes and diabetes were >4.44 [80.1%, 71.1%, 0.834 (0.812–0.854)] and >4.47 [80.6%, 80.8%, 0.909 (0.890–0.926)] respectively. Conclusion: Based on sample of subjects evaluated between 2011 and 2016, TyG index appears to be a promising marker for glucose status conversion among reproductive-aged women in Jakarta, Indonesia. © 2021 |
Conversion; Glucose; Reproductive; TyG index; Women |
biological marker; cholesterol; glucose; hemoglobin A1c; high density lipoprotein cholesterol; low density lipoprotein cholesterol; triacylglycerol; adult; Article; cholesterol blood level; cohort analysis; controlled study; data analysis software; diabetes mellitus; evaluation study; female; follow up; glucose blood level; groups by age; human; impaired glucose tolerance; Indonesia; major clinical study; middle aged; oral glucose tolerance test; outcome assessment; predictive value; receiver operating characteristic; reference value; remission; reproduction; retrospective study; sensitivity and specificity; statistical analysis; triacylglycerol blood level; triglyceride glucose index; young adult |
Elsevier Ltd |
18714021 |
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34562866 |
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