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No records
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621 |
George P.M.A., Abdullah S., Rachman A. |
57221954733;57204563168;57217184320; |
Analysis of Hypothyroidism Development in Post-Radiotherapy Nasopharyngeal Cancer Patients using Survival Trees |
2021 |
Journal of Physics: Conference Series |
1722 |
1 |
012095 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100712595&doi=10.1088%2f1742-6596%2f1722%2f1%2f012095&partnerID=40&md5=b152a0810c9274777e385793bf11e707 |
Department of Mathematics, Universitas Indonesia, Kampus Baru UI, Depok, 16424, Indonesia; Department of Oncology, Faculty of Medicine, Universitas Indonesia, Depok, 16424, Indonesia |
George, P.M.A., Department of Mathematics, Universitas Indonesia, Kampus Baru UI, Depok, 16424, Indonesia; Abdullah, S., Department of Mathematics, Universitas Indonesia, Kampus Baru UI, Depok, 16424, Indonesia; Rachman, A., Department of Oncology, Faculty of Medicine, Universitas Indonesia, Depok, 16424, Indonesia |
Radiotherapy is one of the treatments for nasopharyngeal cancer (NPC). However, this treatment might produce an unfavorable effect on the thyroid gland, which eventually results in less production of thyroid hormone. This is condition is known as hypothyroidism. The development of hypothyroidism in each patient with post-radiative NPC differs according to several factors. This study aims to analyze the rate of development of hypothyroidism in post-radiated NPC patients. This aim is achieved by identifying subgroups of patients with different hazard rates of developing hypothyroidism, and further identify factors explaining hypothyroidism in each subgroup. Data on ninety-seven NPC post-radiation patients taken from one of the hospitals in Jakarta were analyzed. Survival tree with the relative risk tree algorithm was proposed to analyze the data. We identified three subgroups of patients with relatively slow, medium, and fast developing of hypothyroidism. For the slow subgroup, 26% of the patients developed hypothyroidism at 150+ weeks post-radiation, while it only took less than 30 weeks for those in fast-growing subgroup; and 70 until 130 weeks for the medium subgroup. We also found that sweat production and Zulewski's total score were the important factors in explaining the development rate of hypothyroidism. © 2021 Institute of Physics Publishing. All rights reserved. |
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Clustering algorithms; Diseases; Forestry; Information analysis; Radiotherapy; Development rate; Hazard rates; Jakarta; Nasopharyngeal cancer; Relative risks; Thyroid glands; Thyroid hormones; Tree algorithms; Trees (mathematics) |
IOP Publishing Ltd |
17426588 |
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Conference Paper |
Q4 |
210 |
18731 |
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622 |
Budianto I.R., Firmansyah A., Moenadjat Y., Jusuf A.A., Soetikno V. |
56072591000;57430911900;57190371576;57192275719;36769252100; |
In vivo model of Hirschsprung-associated enterocolitis using benzalkonium chloride |
2021 |
Medical Journal of Indonesia |
30 |
4 |
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239 |
244 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123725324&doi=10.13181%2fmji.oa.215339&partnerID=40&md5=0d7ad27ed35c326eece4ebc9bb2d637b |
Biomedical Doctoral Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Surgery, School of Medicine and Health Sciences, Universitas Katolik Indonesia Atma Jaya, Jakarta, Indonesia; Department of Pediatric, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Budianto, I.R., Biomedical Doctoral Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Surgery, School of Medicine and Health Sciences, Universitas Katolik Indonesia Atma Jaya, Jakarta, Indonesia; Firmansyah, A., Department of Pediatric, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Moenadjat, Y., Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Jusuf, A.A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Soetikno, V., Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND Hirschsprung-associated enterocolitis (HAEC) is a life-threatening complication of Hirschsprung’s disease. Studies using animal models on the pathogenesis of HAEC are limited. Thus, this study aimed to establish a rat model of HAEC using topical application of 0.1% benzalkonium chloride (BAC) in the sigmoid colon. METHODS 55 male Sprague Dawley rats aged 10−12 weeks old were separated into 11 groups. The control group (n = 5) was euthanized on day-7, and the other 10 groups (n = 5 in each group) treated with 0.1% BAC in the sigmoid colon for 15 min to induce Hirschsprung’s disease were euthanized on day-7,-10,-12,-14,-17,-19,-21,-23,-25, and-28. The sigmoid colon was excised, fixed in formalin, and sectioned for histological examinations with hematoxylin and eosin staining. The degree of HAEC was compared within all groups. RESULTS Rats that were sacrificed on day-7 to-12 showed the 1st degree or early HAEC, which was most likely caused by BAC application. The 2nd degree of HAEC occurred in rats that were sacrificed on day-14 that showed a macrophage infiltration in the sigmoid colon, thus fulfilled the initial criteria for HAEC (p = 0.0025 versus control). The degree of enterocolitis increased with time, and the highest degree was found in rats that were sacrificed on day-28 (p<0.001 versus control). CONCLUSIONS Topical application of 0.1% BAC for 15 min was successfully produced HAEC model in rats, which was occurred on day-14 after the application. This model provides a useful resource for further research on the pathogenesis of HAEC. © 2021 Authors. |
Animal model; Colitis; Ganglions; Hirschsprung’s disease |
benzalkonium chloride; eosin; hematoxylin; isoflurane; ketamine; xylazine; aganglionosis; animal model; animal tissue; anorexia; Article; autopsy; cell proliferation; cervical spine dislocation; controlled study; crypt cell; enterocolitis; Hirschsprung disease; in vivo study; laparotomy; macrophage; male; mucosa ulceration; necrosis; neutrophil chemotaxis; nonhuman; rat; sham procedure; sigmoid; Sprague Dawley rat; ulcer |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Article |
Q4 |
164 |
21905 |
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623 |
Winarto H. |
54080645300; |
The importance of identification for a stress urinary incontinence after pelvic orgaprolapse vaginal repair |
2021 |
Medical Journal of Indonesia |
30 |
4 |
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237 |
238 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123709235&doi=10.13181%2fmji.ed.215971&partnerID=40&md5=ee09f6c4f49a5e6e13609c2191a488f0 |
Medical Journal of Indonesia, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Winarto, H., Medical Journal of Indonesia, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
[No abstract available] |
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editorial; Editorial; female; human; pelvic organ prolapse; postoperative complication; stress incontinence; vagina reconstruction |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Editorial |
Q4 |
164 |
21905 |
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624 |
Djusad S., Nizomy I.R., Hakim S., Priyatini T., Moegni F., Meutia A.P., Imsantoso B. |
57192276788;57267769100;57192276095;57192265423;55450456100;57203368133;57431312700; |
Incidence and characteristics of de novo stress urinary incontinence after pelvic organ prolapse vaginal repair |
2021 |
Medical Journal of Indonesia |
30 |
4 |
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245 |
249 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123677566&doi=10.13181%2fmji.oa.204163&partnerID=40&md5=9b2deb933d7d42f78f8cd27103bdad59 |
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Lambung Mangkurat, Ulin General Hospital, South Kalimantan, Indonesia |
Djusad, S., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Nizomy, I.R., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Lambung Mangkurat, Ulin General Hospital, South Kalimantan, Indonesia; Hakim, S., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Priyatini, T., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Moegni, F., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Meutia, A.P., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Imsantoso, B., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
BACKGROUND Some patients who undergo pelvic floor reconstruction for pelvic organ prolapse (POP) may experience a de novo stress urinary incontinence (SUI) postoperatively. We aimed to investigate the incidence and characteristics of de novo SUI in patients who underwent pelvic floor reconstruction at the national referral hospital in Indonesia. METHODS This cross-sectional study evaluated 108 patients who underwent pelvic floor reconstruction due to POP between January 2016 and December 2017. Per the inclusion criteria, 75 women were enrolled using a consecutive sampling. The incidence of de novo SUI was determined 6–12 months postoperatively using the Indonesian version of the questionnaire for urinary incontinence diagnosis and objectively using the cough stress test during gynecologic examination after a negative preoperative prolapse reduction stress test. RESULTS The average age, parity, body mass index, and years since menopause onset were 56.17 (4.67) years, 3.17 (1.07), 28.58 (5.18) kg/m2, and 12.8 (7.0) years, respectively. De novo SUI was seen in 8.0% (6 of 75) patients at 6–7 months postoperatively, with 3 (50.0%) had severe POP and 3 (50.0%) had a mild POP. Most of these patients (4 of 6, 66.7%) had undergone procedures other than colpocleisis for POP reconstruction. CONCLUSIONS The incidence of de novo SUI after gynecologic surgery for POP at a national referral hospital in Indonesia is 8%. Most patients were aged <60 years, had a parity of <4, were nonobese, were menopausal, and had diabetes. © 2021 Authors. |
Gynecologic surgery; Pelvic organ prolapse; Tertiary referral center; Urinary stress incontinence |
adult; Article; bladder function test; body mass; cough stress test; cross-sectional study; diabetes mellitus; female; gynecological examination; human; incidence; major clinical study; middle aged; parity; pelvic organ prolapse; preoperative prolapse reduction stress test; stress incontinence; vagina reconstruction |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Article |
Q4 |
164 |
21905 |
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627 |
Aninditha T., Pratama P.Y., Sofyan H.R., Imran D., Estiasari R., Octaviana F., Iskandar M.M., Odilo J., Werdhani R.A., Aman R.A., Ranakusuma T.A.S. |
57189611205;57450416000;57328366500;57203976849;55240204000;26029958700;57205414462;57450963600;57189088848;36848942500;7801656487; |
Adults brain tumor in Cipto Mangunkusumo General Hospital: A descriptive epidemiology |
2021 |
Romanian Journal of Neurology/ Revista Romana de Neurologie |
20 |
4 |
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480 |
484 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85124554663&doi=10.37897%2fRJN.2021.4.13&partnerID=40&md5=b5302d49e5e258bb7f13476b33682fdc |
Department of Neurology, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Department of Neurology, Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi, Indonesia; Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia |
Aninditha, T., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Pratama, P.Y., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Sofyan, H.R., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Imran, D., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Estiasari, R., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Octaviana, F., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Iskandar, M.M., Department of Neurology, Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi, Indonesia; Odilo, J., Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Werdhani, R.A., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Aman, R.A., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia; Ranakusuma, T.A.S., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia |
Background. Brain tumor is a rare tumor with low incidence. Although it is a rare tumor, the mortality of brain tumor is disproportionately high. Many countries have already published epidemiology of brain tumor. However, the epidemiology of brain tumor in Indonesia remains to be investigated. This article aimed to provide descriptive epidemiology of brain tumor. Methods. The data of brain tumor acquired from Department of Neurology and Neurosurgery Cipto Mangunkusumo General Hospital from 2014 to 2016. The histopathology classification of primary intracranial tumors was based on WHO classification of CNS tumors 2016 while brain metastasis was classified based on other histopathological types. The vari-ables were analyzed and presented descriptively. Results. There were 316 subjects acquired in this study. Most of the subjects (68%) were women. The mean age of this study was 43.8 (11.7). Most of the subjects (86.1%) had primary histopathology. Lung cancer was the most commonly found brain metastasis in this study (34.1%). Conclusions. This is a pilot study of brain tumor epidemiology in Indonesia. Collaboration with other centers in Indonesia is needed to give a more representative insight of brain tumor in Indonesia. © 2021, Editura Medicala. All rights reserved. |
Brain tumor; Cancer; Descriptive study; Epidemiology |
adenoma; adult; Article; brain hemorrhage; brain metastasis; brain tumor; cancer grading; cancer localization; cancer staging; central nervous system tumor; cross-sectional study; female; general condition; general hospital; glioblastoma; glioma; histopathology; human; human tissue; immunohistochemistry; intracranial metastasis; intracranial tumor; lung cancer; major clinical study; male; meningioma; middle aged; neurosurgery; pilot study; retrospective study |
Editura Medicala |
20696094 |
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Article |
Q4 |
111 |
28569 |
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633 |
Nadia Y.F., Syahrani R.A., Arumsari S., Sadikin M., Wanandi S.I. |
57428347800;57204103147;57193202336;36981411100;36099320700; |
Effect of Cell Culture Medium on the Proliferation and Stemness of CD24-/CD44+ Human Breast Cancer Stem Cells |
2021 |
Indonesian Biomedical Journal |
13 |
4 |
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355 |
363 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123550895&doi=10.18585%2fINABJ.V13I4.1674&partnerID=40&md5=f0c363bff3a069d364bc71970a109469 |
Master’s Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia; Molecular Biology and Proteomics Core Facilities, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia |
Nadia, Y.F., Master’s Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia; Syahrani, R.A., Molecular Biology and Proteomics Core Facilities, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia; Arumsari, S., Molecular Biology and Proteomics Core Facilities, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia; Sadikin, M., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia; Wanandi, S.I., Molecular Biology and Proteomics Core Facilities, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia, Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia, Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Kenari, Jakarta, 10430, Indonesia |
BACKGROUND: Cancer stem cells (CSCs) is defined as tumor initiating cells within tumor that maintain stemness properties and tumorigenicity. Extracellular pH of CSCs in in vitro condition is important for supporting cell proliferation which may also regulate the expression of stemness markers such as OCT4. This work aimed to examine the effect of cell culture media on the proliferation and stemness of human breast cancer stem cells (BCSCs). RESULTS: Our results showed a higher viable cell number and proliferation of BCSCs in DMEM/F-12 HEPES (-) compared to HEPES (+) medium until 4 day incubation. OCT4 mRNA and protein level, as well as MFU of BCSCs were significantly higher in HEPES (-) compared to HEPES (+) medium on day 2. CONCLUSION: DMEM/F-12 medium without HEPES facilitates CD24-/CD44+ BCSCs to have higher proliferation and stemness on day 2 incubation compared to those with HEPES. © 2021. All Rights Reserved. |
breast cancer; cancer stem cell; OCT4; proliferation; stemness |
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Prodia Education and Research Institute |
20853297 |
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Article |
Q4 |
160 |
22228 |
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634 |
Fachrucha F., Andarini S., Elhidsi M., Irawan R.Y., Beginta R., Sutoyo D.K. |
57224454767;8716259500;57203157152;57224450720;57428288200;6506079672; |
Pulmonary alveolar proteinosis with secondary Aspergillus infection: A case report |
2021 |
Journal of Health Sciences |
11 |
3 |
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191 |
195 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123527299&doi=10.17532%2fJHSCI.2021.1366&partnerID=40&md5=7d23bb20bec93b3f95d06cf257dca574 |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Department of Anatomic Pathology, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia |
Fachrucha, F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Andarini, S., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Elhidsi, M., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Irawan, R.Y., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Beginta, R., Department of Anatomic Pathology, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Sutoyo, D.K., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia |
Pulmonary alveolar proteinosis (PAP) is a rare disease with mostly due to autoimmune toward granulocyte-macropahge colony-stimulating factor. In some conditions, PAP followed with secondary infection. A 34-year-old woman came with progressive shortness of breath, chronic dry cough, and mild fever. The chest High-Resolution Computed Tomography showed ground-glass opacity with septal reticulation or known as the crazy-paving pattern, and a cavity on the upper lobe of the left lung. The patient underwent bronchoscopy for diagnostic and therapeutic measures and found milky appearance bronchoalveolar lavage fluid (BALF). The serum galactomannan came out positive. Fungal infection detected from the BALF culture, Aspergillus fumigatus, hence fulfilling the diagnosis of PAP with probable invasive pulmonary aspergillosis. The patient showed clinical improvement after undergoing whole lung lavage and given anti-fungal medications © 2022 Fachrucha, et al.; licensee University of Sarajevo - Faculty of Health Studies |
Fungal infection; Milky appearance bronchoalveolar lavage fluid; Pulmonary alveolar proteinosis; Whole lung lavage |
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University of Sarajevo - Faculty of Health Studies |
22327576 |
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Article |
Q4 |
112 |
28273 |
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637 |
Tjoa K., Kusmardi K., Midoen Y.H. |
57222366705;56966625300;57197805109; |
Effects of Industrial Waste Fish Oil Administration on Interleukin-6 (Il-6) Expression at Mice Colon being Induced by Azoxymethane (AOM) and Dextran Sodium Sulphate (DSS) |
2021 |
Biomedical and Pharmacology Journal |
14 |
4 |
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2227 |
2233 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122824976&doi=10.13005%2fbpj%2f2321&partnerID=40&md5=bc79b4fdfe0aaabc3c89256150a440fb |
Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia; Departement of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia; Drug Development Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia; Human Cancer Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia; Departement of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Tjoa, K., Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia; Kusmardi, K., Departement of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia, Drug Development Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia, Human Cancer Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia; Midoen, Y.H., Departement of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Colorectal cancer (CRC) is the world's third most cancer and the second highest mortality rate. The searching for new anti-inflammation substances with less adverse effects than aspirin for chemoprevention and adjuvant chemotherapy of CRC is running. The most notable one is fish oil containing omega 3. Kusmardi, et al. studied that industrial waste fish oil omega-3 level comes close enough to conventional fish oil industry. Study aims to reducing the level IL-6 on mice colon tissue being induced CRC using AOM/DSS by fish oil administration. Thirty male Swiss Webster mice are grouped into six treatments: Positive control (aspirin), negative control (physiological saline), normal, high dose (fish oil 6mg/kgBW), medium dose (fish oil 3mg/kgBW), dan solvent control (corn oil). Colon tissue was stained using anti IL-6 antibody. Ten photos per slide were taken by microscope (400x), analyzed for the IL-6 expression by ImageJ®, and quantified for H-score. Data was analyzed using SPSS 24.0 (CI 95%) and p-value <0.05 is consider significant. Data are not normally distributed with median of 161.64 (119.4-260.67). Kruskal-Wallis test is significant in addition with Mann-Whitney test shows only high dose group has significant difference to negative control (p=0.008), medium dose (p=0.016) dan and solvent control (p=0.008). No significant difference reported between high dose and positive control group (p=0.69). High dose industrial waste fish oil can lower IL-6 expression in mice colon tissue induced CRC using AOM/DSS. © 2021 Oriental Scientific Publishing Company. |
Colitis Associated Cancer; Colorectal cancer; Interleukin-6; Omega-3 Fish Oil |
acetylsalicylic acid; CD34 antigen; cytochrome P450 2E1; fish oil; interleukin 6; microRNA; nonsteroid antiinflammatory agent; octamer transcription factor 4; probiotic agent; adjuvant chemotherapy; animal experiment; animal model; animal tissue; antiinflammatory activity; Article; azoxymethane-induced colon carcinogenesis; carcinogenesis; cardiovascular disease; cell proliferation; chemoprophylaxis; colon cancer; colon tissue; colorectal cancer; controlled study; dextran sulfate sodium-induced colitis; DNA methylation; drug megadose; fat intake; genomic instability; histone modification; immunohistochemistry; industrial waste; male; mortality rate; mouse; nonhuman; obesity; peritoneum adhesion; protein expression; quantitative analysis; rheumatoid arthritis; ulcerative colitis |
Oriental Scientific Publishing Company |
09746242 |
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Article |
Q4 |
191 |
19920 |
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639 |
Rajabto W., Angkasa Y.K., Harahap A.S., Ham M.F., Brahma B. |
36519576100;57404644300;57218511857;57257336600;55675752700; |
Primary breast lymphoma – a case report [Primární lymfom prsu – kazuistika] |
2021 |
Klinicka Onkologie |
34 |
6 |
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477 |
480 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122541181&doi=10.48095%2fccko2021477&partnerID=40&md5=d7901c39e0619899ff18efe6ce8ac36f |
Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital/ Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomical Pathology, Dr. Cipto Mangunkusumo General Hospital/ Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Surgical Oncology, Dharmais National Cancer Hospital, Jakarta, Indonesia |
Rajabto, W., Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital/ Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Angkasa, Y.K., Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital/ Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Harahap, A.S., Department of Anatomical Pathology, Dr. Cipto Mangunkusumo General Hospital/ Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ham, M.F., Department of Anatomical Pathology, Dr. Cipto Mangunkusumo General Hospital/ Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Brahma, B., Department of Surgical Oncology, Dharmais National Cancer Hospital, Jakarta, Indonesia |
Background: Primary breast lymphoma is a rare disease and accounts for 0.4–0.5% of malignant breast neoplasms and 1.7–2.2% of extra-nodal lymphomas, with diffuse large B-cell lymphoma (DLBCL) as the most common histologic subtype. Case: A 47-year-old female with beta thalassemia presented with a lump of the left breast, redness, pain, and swelling of her left breast. Physical examination showed tender, red, swollen left breast. Laboratory findings show mild anemia and normal level of lactate dehydrogenase 329 U/L (normal range: 240–480 U/L). PET scan showed hypermetabolic mass with irregular margins covering the whole left breast quadrants with the size of 11.25 × 5.17 cm with left pectoralis major, left parasternal, and left axillary hypermetabolic nodules. Histopathology and immunohistochemistry staining showed a non-germinal center B-cell-like subtype of DLBCL CD20+. We administered the R-CHOP regi-men (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednison) every 3 weeks for 6 cycles. The response was complete remission. The patient tolerated the chemotherapy well and achieved long term complete remission. Conclusion: Primary breast lymphoma is a rare disease with the most common subtype is diffuse large B-cell lymphoma. Systemic chemotherapy R-CHOP is the treatment option for primary breast diffuse large B-cell lymphoma. © 2021, Czech Medical Association J.E. Purkyne. All rights reserved. |
Diffuse large B-cell lymphoma; Primary breast lymphoma; R-CHOP chemotherapy |
CD20 antigen; cyclophosphamide plus doxorubicin plus prednisolone plus rituximab plus vincristine; protein bcl 2; protein bcl 6; antineoplastic agent; cyclophosphamide; doxorubicin; prednisone; R-CHOP protocol; rituximab; vincristine; adult; alopecia; anemia; Article; axillary lymph node; axillary mass; beta thalassemia; breast biopsy; breast cancer; breast tenderness; cancer combination chemotherapy; cancer regression; case report; clinical article; color Doppler flowmetry; diffuse large B cell lymphoma; echomammography; female; histopathology; human; human tissue; immunohistochemistry; laboratory test; middle aged; multiple cycle treatment; nausea and vomiting; neutropenia; pectoralis major muscle; peripheral neuropathy; physical examination; positron emission tomography; primary tumor; |
Czech Medical Association J.E. Purkyne |
0862495X |
|
34911334 |
Article |
Q4 |
204 |
19085 |
|
|
|
642 |
Soetisna T.W., Namretta L., Tirta E.S., Catur M.M.S.P., Ronidipta B., Tjubandi A. |
57214887740;57394531400;57221753958;57394432600;57394432700;57211055979; |
The importance of differentiating types of myxoma: a case report |
2021 |
Cor et Vasa |
63 |
6 |
|
733 |
735 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122153861&doi=10.33678%2fCOR.2021.063&partnerID=40&md5=ece88060ac36e8ce762e466c1383e95a |
Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Centre Harapan Kita, Jakarta, Indonesia; Department of Surgery, Faculty of Medicine, Universitas Indonesia, Indonesia |
Soetisna, T.W., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Centre Harapan Kita, Jakarta, Indonesia, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Indonesia; Namretta, L., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Centre Harapan Kita, Jakarta, Indonesia; Tirta, E.S., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Centre Harapan Kita, Jakarta, Indonesia; Catur, M.M.S.P., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Centre Harapan Kita, Jakarta, Indonesia; Ronidipta, B., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Centre Harapan Kita, Jakarta, Indonesia; Tjubandi, A., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Centre Harapan Kita, Jakarta, Indonesia, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Indonesia |
Myxoma shows unspecific symptoms similar to other cardiac disorders. Late resection of myxoma will worsen output such as congestive heart failure, cardiac arrhythmia, and cardiac embolism, causing sudden death. Early diagnosis and surgical excision of cardiac myxomas, especially with the villous surface, must be done as soon as possible. Additional diagnostic examination was needed to define types of myxoma for earlier treatment to prevent complications. We present a case of atrial myxoma which was diagnosed and treated earlier than the median time reviewed by the previous study. This paper focuses on the importance of early diagnosis and defining types of myxoma. © 2021, ČKS. |
Myxoma; Tumor; Villous surface |
adult; cardiopulmonary bypass; case report; clinical article; color Doppler flowmetry; dyspnea; early diagnosis; heart atrium myxoma; heart atrium septum defect; human; human tissue; male; middle aged; mitral valve regurgitation; physical examination; Review; sinus bradycardia; sternotomy; transthoracic echocardiography |
Czech Society of Cardiology Z.S |
00108650 |
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Review |
Q4 |
177 |
20889 |
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