634 |
Fachrucha F., Andarini S., Elhidsi M., Irawan R.Y., Beginta R., Sutoyo D.K. |
57224454767;8716259500;57203157152;57224450720;57428288200;6506079672; |
Pulmonary alveolar proteinosis with secondary Aspergillus infection: A case report |
2021 |
Journal of Health Sciences |
11 |
3 |
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191 |
195 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123527299&doi=10.17532%2fJHSCI.2021.1366&partnerID=40&md5=7d23bb20bec93b3f95d06cf257dca574 |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Department of Anatomic Pathology, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia |
Fachrucha, F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Andarini, S., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Elhidsi, M., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Irawan, R.Y., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Beginta, R., Department of Anatomic Pathology, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Sutoyo, D.K., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia |
Pulmonary alveolar proteinosis (PAP) is a rare disease with mostly due to autoimmune toward granulocyte-macropahge colony-stimulating factor. In some conditions, PAP followed with secondary infection. A 34-year-old woman came with progressive shortness of breath, chronic dry cough, and mild fever. The chest High-Resolution Computed Tomography showed ground-glass opacity with septal reticulation or known as the crazy-paving pattern, and a cavity on the upper lobe of the left lung. The patient underwent bronchoscopy for diagnostic and therapeutic measures and found milky appearance bronchoalveolar lavage fluid (BALF). The serum galactomannan came out positive. Fungal infection detected from the BALF culture, Aspergillus fumigatus, hence fulfilling the diagnosis of PAP with probable invasive pulmonary aspergillosis. The patient showed clinical improvement after undergoing whole lung lavage and given anti-fungal medications © 2022 Fachrucha, et al.; licensee University of Sarajevo - Faculty of Health Studies |
Fungal infection; Milky appearance bronchoalveolar lavage fluid; Pulmonary alveolar proteinosis; Whole lung lavage |
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University of Sarajevo - Faculty of Health Studies |
22327576 |
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Article |
Q4 |
112 |
28273 |
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748 |
Karina K., Ekaputri K., Biben J.A., Purwoko R.H., Sibuea T.P., Astuti S.L., Loho A.M., Limengka Y., Nelfidayani, Agustini S., Krisandi G., Maryam A., Rosadi I., Rosliana I., Sobariah S., Subroto W.R., Afini I., Widyastuti T., Zakiyah A., Ernanda D., Aini N., Jusryanti, Sulaeha A.D., Prestiani S.I., Donna I.M., Habibi, Mutiara M.S. |
57212146678;57285088000;55947833300;57286031400;57286487800;57285797400;57223264641;37029815800;57286487900;57286488000;57225009844;57286260300;57204720098;57186671400;57203547382;57218940654;57211068324;57211074403;57226293808;57226273639;57226289464;57286944600;57226286645;57283770100;57284210300;57285797500;57284210400; |
Evaluating the Safety of Intravenous Delivery of Autologous Activated Platelet-rich Plasma |
2021 |
Journal of Health Sciences |
11 |
2 |
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61 |
65 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111033469&doi=10.17532%2fjhsci.2021.1276&partnerID=40&md5=b0a026ecaccc92d972564c5dfd1f4824 |
Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia; Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, Jakarta, Indonesia; Pusat Kajian Stem Cell, Universitas Pembangunan Nasional Veteran Jakarta, Jakarta, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, Mulawarman University, Indonesia |
Karina, K., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia, Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, Jakarta, Indonesia, Pusat Kajian Stem Cell, Universitas Pembangunan Nasional Veteran Jakarta, Jakarta, Indonesia; Ekaputri, K., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Biben, J.A., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Purwoko, R.H., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Sibuea, T.P., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Astuti, S.L., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Loho, A.M., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Limengka, Y., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Nelfidayani, Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Agustini, S., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Krisandi, G., Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Maryam, A., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Rosadi, I., Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia, Department of Biology, Faculty of Mathematics and Natural Sciences, Mulawarman University, Indonesia; Rosliana, I., Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia; Sobariah, S., Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia; Subroto, W.R., Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia; Afini, I., Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia; Widyastuti, T., Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia; Zakiyah, A., Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia; Ernanda, D., Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia; Aini, N., Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia; Jusryanti, Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Sulaeha, A.D., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Prestiani, S.I., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Donna, I.M., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Habibi, Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Mutiara, M.S., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia |
Introduction: Autologous platelet-rich plasma (PRP) has been a growing trend in the field of medicine due to its broad range of application and is considered safe from bloodborne diseases. Furthermore, various studies have tried to optimize the use of autologous PRP through various preparation protocols, including PRP activation. However, most of the studies available have not evaluated the safety for intravenous delivery of PRP, especially autologous activated PRP (aaPRP). Therefore, this study aimed to evaluate the safety of intravenous delivery of aaPRP. Methods: Blood was drawn from each patient and aaPRP was isolated through calcium activation and light irradiation. Each aaPRP was administered intravenously to all patients. Adverse events were documented and analyzed. Results: Six hundred eleven patients participated in this study with a total of 4244 aaPRP therapies. Quality control of autologous aaPRP showed no platelets present after both calcium activation and light irradiation. No adverse events such as allergic reaction, infection, and coagulation problems were observed on all patients over the course of the study. Conclusion: Our results showed that intravenous administration of autologous aaPRP is safe even in patients with various pathological conditions. © 2021. Karina Karina, et al.; licensee University of Sarajevo - Faculty of Health Studies. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Intravenous infusion; platelet-rich plasma; safety |
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University of Sarajevo - Faculty of Health Studies |
22327576 |
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Article |
Q4 |
112 |
28273 |
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791 |
Elhidsi M., Fachrucha F., Irawan R.Y. |
57203157152;57224454767;57224450720; |
N-Acetylcysteine for coronavirus disease-19: A potential adjuvant therapy |
2021 |
Journal of Health Sciences |
11 |
1 |
|
1 |
6 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107532673&doi=10.17532%2fjhsci.2020.1156&partnerID=40&md5=54f33bc66788c4c394abb216fff7bce9 |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia |
Elhidsi, M., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Fachrucha, F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Irawan, R.Y., Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia |
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) infection or known as coronavirus disease 2019 (COVID-19) is a highly infectious disease that has been declared as a world pandemic by WHO. Although the majority of patients only experience mild symptoms, older patients and those with comorbidities are in the risk of falling into critically ill and even death. This is thought to correlate with systemic inflammatory response and oxidative stress imbalance. N-acetylcysteine (NAC) is recognized as a potent mucolytic, yet its lesser-known function as an antioxidant is a precursor of glutathione. Basic aspects and either in vivo or in vitro studies showed various mechanisms of NAC acting as a counterbalance in viral infections and its role in decreasing inflammation and oxidative stress. High-dose NAC is reported to be effective as an antioxidant in pneumonia, influenza, sepsis, and acute respiratory distress syndrome. Early evidence in COVID-19 patients showed that NAC could be beneficial. This review gives the scientific background in considering NAC as an adjuvant treatment for COVID-19. © 2021. Mia Elhidsi et al;. All Rights Reserved. |
Antioxidant; coronavirus disease-19; glutathione; N-acetylcysteine; oxidative stress |
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University of Sarajevo - Faculty of Health Studies |
22327576 |
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Article |
Q4 |
112 |
28273 |
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