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No records
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648 |
Sungkar A. |
55110453800; |
Preterm birth in low-resource setting |
2021 |
Donald School Journal of Ultrasound in Obstetrics and Gynecology |
15 |
2 |
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175 |
178 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121540929&doi=10.5005%2fjp-journals-10009-1695&partnerID=40&md5=6bdfb4b0abc69737097e5332647cdcc6 |
Fetomaternal Division, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Cipto Mangunkusumo National Hospital, Jakarta, Indonesia |
Sungkar, A., Fetomaternal Division, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia |
Preterm labor (PTL) is a global problem which is a complex disease with a high rate of morbidity and mortality, also has long-term consequences for the baby and the family. The well-known morbidities related to PTL are respiratory distress syndrome, necrotizing enterocolitis, intraventricular hemorrhage, retinopathy of prematurity, and anemia of prematurity. In a developing country, the management of PTL is limited by poor health systems, low education level of the mother, poor financial support, lack of facility and trained health personnel, and demographic barriers. This limitation leads to high morbidity and mortality of preterm birth, especially in developing countries. It is important to reduce the rate of preterm birth by preventing the event. Several risk factors have been identified and are avoidable and preventable, such as smoking, bacterial infection, poor nutritional status, and malnourished mothers. Strategies to prevent PTL have been proposed in primary, secondary, and tertiary interventions to reduce the morbidity and mortality of preterm birth. © Jaypee Brothers Medical Publishers. 2021. |
Management; Morbidity and mortality; Preterm labor; Risk factor |
fibronectin; folic acid; homocysteine; iron; trace element; zinc; allergy; body mass; cigarette smoking; early diagnosis; endocrine disease; gestational weight gain; graft rejection; human; hyperhomocysteinemia; hypertension; infertility therapy; intrauterine growth retardation; intrauterine infection; ischemia; macronutrient; morbidity; mortality; multiple pregnancy; non communicable disease; nutritional deficiency; preeclampsia; pregnancy diabetes mellitus; premature labor; prepregnancy care; Review; risk factor; transvaginal echography; uterine cervix carcinoma in situ; uterine cervix incompetence; vascular disease |
Jaypee Brothers Medical Publishers (P) Ltd |
0973614X |
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Review |
Q4 |
162 |
22036 |
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672 |
Tunjungputri R.N., Tetrasiwi E.N., Veronica M., Pandelaki J., Ibrahim F., Nelwan E.J. |
56342194400;57267704700;57268337000;35759266900;54886001500;14527452900; |
Vaccine-Associated Disease Enhancement (VADE): Considerations in Postvaccination COVID-19 |
2021 |
Case Reports in Medicine |
2021 |
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9673453 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118971098&doi=10.1155%2f2021%2f9673453&partnerID=40&md5=ddb9dd4ce5b8de10f0e4c9c43c6cd496 |
Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Radiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Microbiology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Tropical and Infectious Diseases, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Infectious Disease and Immunology Research Center - IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Tunjungputri, R.N., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Tetrasiwi, E.N., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Veronica, M., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Pandelaki, J., Department of Radiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Ibrahim, F., Microbiology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Nelwan, E.J., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia, Division of Tropical and Infectious Diseases, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia, Infectious Disease and Immunology Research Center - IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Introduction. The COVID-19 pandemic has entered a new phase with the roll-out of several vaccines worldwide at an accelerated phase. The occurrence of a more severe presentation of COVID-19 after vaccination may affect policymakers' decision-making and vaccine uptake by the public. Vaccine-associated disease enhancement (VADE) is the modified presentation of infections in individuals after having received a prior vaccination. Currently, little is known about the potential of vaccine-associated disease enhancement (VADE) following COVID-19 immunization. Case Illustration. We herewith report two patients admitted with confirmed COVID-19 pneumonia with a history of CoronaVac vaccination. The first patient with a relatively milder course of the disease had received two doses of CoronaVac, whereas the second patient with a more progressive course of the disease received only one dose before developing symptoms and being admitted to the hospital. Our observations suggest that vaccination could act in boosting the inflammatory process and reveal the previously asymptomatic COVID-19 illness. Theoretically, vaccines could induce VADE, where only suboptimal, nonprotective titers of neutralizing antibodies were produced or proinflammatory T-helper type 2 response was induced. Secondly, enhanced respiratory disease (ERD) could manifest, where pulmonary symptoms are more severe due to peribronchial monocytic and eosinophilic infiltration. Understanding VADE is important for the decision-making by the public, clinicians, and policymakers and is warranted for successful vaccination uptake. Conclusion. We report two cases of patients developing COVID-19 shortly after CoronaVac vaccination in which VADE is likely. We recommend that current vaccination strategies consider the measurement of neutralizing antibody titer as a guide in ensuring the safest strategy for mass immunization. Studies are needed to investigate the true incidence of VADE on vaccinated individuals as well as on how to differentiate between VADE and severe manifestations of COVID-19 that are unrelated to vaccination. © 2021 Rahajeng N. Tunjungputri et al. |
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C reactive protein; coronavac; D dimer; fibrinogen; hemoglobin; neutralizing antibody; procalcitonin; adult; antibody titer; Article; asymptomatic coronavirus disease 2019; blood pressure; calcitonin blood level; case report; clinical article; coronavirus disease 2019; COVID-19 testing; electrocardiography; fibrinogen blood level; heart right bundle branch block; hemoglobin blood level; hospital admission; human; hyperglycemia; hypokalemia; hyponatremia; hypoosmolarity; inflammation; laboratory test; leukocyte count; lung examination; male; medical history; middle aged; physical examination; platelet count; protein blood level; real time polymerase chain reaction; thorax radiography; vaccination; vaccine associated disease enhancement; vaccine associated disease enhancement; young adult |
Hindawi Limited |
16879627 |
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Article |
Q4 |
200 |
19317 |
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679 |
Akbar R., George Y., Madjid A.S., Sedono R., Tantri A. |
57317624300;26027840300;57163353500;56660590500;57188933853; |
Early administration of norepinephrine prevents the occurrence of fluid overload in the resuscitation of septic shock patients |
2021 |
Critical Care and Shock |
September 2021 |
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257 |
268 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118270800&partnerID=40&md5=d27a72a8961cf30e6da6e5952895aa23 |
Trainee of Intensive Care Fellowship Program, University of Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Medical Faculty, Haluoleo University-Konawe General Hos-pital, Konawe, Indonesia; Emergency and Intensive Care Unit-Pondok Indah Hospital Jakarta and Departement of Anesthesiology and Intensive Therapy-Faculty of Medicine Universitas, Indonesia; Department of Anesthesiology and Intensive Care, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia |
Akbar, R., Trainee of Intensive Care Fellowship Program, University of Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Medical Faculty, Haluoleo University-Konawe General Hos-pital, Konawe, Indonesia; George, Y., Emergency and Intensive Care Unit-Pondok Indah Hospital Jakarta and Departement of Anesthesiology and Intensive Therapy-Faculty of Medicine Universitas, Indonesia; Madjid, A.S., Department of Anesthesiology and Intensive Care, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Sedono, R., Department of Anesthesiology and Intensive Care, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Tantri, A., Department of Anesthesiology and Intensive Care, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia |
Background: Critically ill patients with sepsis usually receive a very large volume of fluids cau-sing a very significant positive fluid balance in an effort to meet the needs of cardiac output, syste-mic blood pressure, and perfusion to the kidneys. This condition also tends to be associated with poor survival rates. The aim of this study was to determine whether early maintenance of norepi-nephrine can reduce fluid administration and prevent overload in the resuscitation of patients with septic shock. Methods: This study was a randomized, non-blind clinical trial, of which the subjects were adult patients with septic shock admitted to the intensive and emergency care unit from January to November 2020. There were two treatment groups of this study, the early norepinephrine group (NEP group) and the 30 ml/kgBW fluid resuscitation one (Fluid group). The test was con-ducted on the urinary albumin-to-creatinine ra-tio, increase of serum creatinine value, ratio of arterial oxygen partial pressure to fractional in-spired oxygen (PaO2/FiO2 ratio), and intra-ab-dominal pressure at the time of septic shock di-agnosis was established, 3 hours, and 24 hours . after the treatment was given. The data was pro-cessed using the SPSS device. Results: Based on the analysis, it was found that there were significant differences in all study va-riables of the Fluid group compared to the NEP group. The amount of fluid administration in the NEP group averaged 2198.63 ml, less than that in the Fluid group with an average of 3999.30 ml (chi square test p=0.000). By comparing the measurement results to the initial measurement values in the two groups, the fluid overload was high-risk in the Fluid group. There was a significant relationship between the urinary albumin-to-creatinine ratio (OR=48.273; 95% CI=16.708-139.472), the increase in serum crea-tinine value (OR=73.381; 95% CI=19.955-269.849), the low PaO2/FiO2 ratio (OR=12.225; 95% CI=5.290-28.252), and the increase in intra-abdominal pressure (OR=32.667; 95% CI=10.490-101.724) with the provision of 30 ml/kgBW fluid resuscitation, which indicated the risk of fluid overload. Conclusion: Early norepinephrine administration can reduce fluid administration and prevent overload in the resuscitation of patients with septic shock. © 2021, The Indonesian Foundation of Critical Care Medicine. All rights reserved. |
Early norepinephrine; Fluid overload; Septic shock |
noradrenalin; abdominal pressure; adult; aged; albumin to creatinine ratio; albuminuria; Article; blood volume; capillary leak syndrome; controlled study; creatinine blood level; emergency care; female; fraction of inspired oxygen; Horowitz index; human; hypervolemia; intensive care; major clinical study; male; randomized controlled trial; resuscitation; risk; septic shock; Sequential Organ Failure Assessment Score; systolic blood pressure |
The Indonesian Foundation of Critical Care Medicine |
14107767 |
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Article |
Q4 |
134 |
24890 |
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682 |
Safri A.Y., Pawitan J.A. |
57091699300;6508348067; |
Nerve tissue engineering in peripheral nerve injury |
2021 |
International Medical Journal |
28 |
1 |
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16 |
19 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118134217&partnerID=40&md5=f829640cb3d11f1c1fcb1f8558832de1 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Departement of Neurology, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo General Hospital/Faculty of Medicine, Universitas Indonesia, Indonesia; Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia |
Safri, A.Y., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Departement of Neurology, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Pawitan, J.A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo General Hospital/Faculty of Medicine, Universitas Indonesia, Indonesia, Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia |
Objective: This article aims to explain the mechanism of recovery of peripheral nerve injury, current management and progress in nerve tissue engineering, which are promising to overcome the problems of peripheral nerve injury. Materials and Methods: we searched various sources, i.e. Pubmed, Scopus, and Google scholar to collect relevant publica-tions of peripheral nerve injury and its management, including nerve tissue engineering. Results: The development of tissue engineering has made it possible to regenerate nerve tissue by a combination of cell ther-apy, appropriate design of scaffolds and the use of supporting elements. Discussion: Under current management, severe peripheral nerve injury especially injury to the proximal and large diameter nerves still has a poor prognosis. Poor prognosis is mainly due to a mismatch in nerve autograft in both structure and diameter to the host nerve. The advantage of tissue engineering techniques in the management of peripheral nerve injuries is that the engineered nerve tissue can be designed according to the structure and diameter of the damaged nerve. Conclusion: Nerve tissue engineering might overcome the problems in peripheral nerve regeneration by a combination of stem cell therapy, and appropriate design of scaffolds to provide nerve conduits. © 2021 Japan University of Health Sciences & Japan International Cultural Exchange Foundation. |
Peripheral nerve injury; Scaffolds; Stem cell; Tissue engineering |
Article; autograft; cell body; cell differentiation; ganglion; human; nerve cell; nerve fiber regeneration; nerve regeneration; nervous system; peripheral nerve injury; stem cell transplantation; systematic review; tissue engineering; tissue regeneration |
Japan International Cultural Exchange Foundation |
13412051 |
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Article |
Q4 |
183 |
20490 |
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685 |
Lubis A.M.T., Reksoprodjo A.Y., Kuncoro M.W., Ifran N.N. |
15122639800;57208385626;57214136871;56091403800; |
Post-acl reconstruction graft failure in severe gout arthritis patient |
2021 |
International Medical Case Reports Journal |
14 |
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725 |
730 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117588489&doi=10.2147%2fIMCRJ.S325642&partnerID=40&md5=7d6c96304b0f081df9890285db073149 |
Department of Orthopedic & Traumatology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Lubis, A.M.T., Department of Orthopedic & Traumatology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Reksoprodjo, A.Y., Department of Orthopedic & Traumatology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kuncoro, M.W., Department of Orthopedic & Traumatology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ifran, N.N., Department of Orthopedic & Traumatology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Introduction: Pain and instability following an anterior cruciate ligament (ACL) reconstruction remain a significant issue. Common causes include infection and inflammation, and mechanical issues such as graft failure. Case Presentation: A 36-year-old male with an ACL reconstruction six years prior was admitted due to pain and swelling. The ACL graft that had ruptured was found arthrosco-pically. Numerous gout crystals and tophus were observed inside. This finding is suggested as a cause of this kind of complication. Discussion: Biological failure is one of the causes of graft failure. Gout arthritis is associated with internal derangement of the joint structures, which is reported in advanced case. Conclusion: Severe gouty arthritis, even though rare, could be an etiology of graft failure following ACL reconstruction and cause significant morbidity. © 2021 Lubis et al. |
ACL reconstruction; Gout; Graft failure; Tophus |
urate; adult; anterior cruciate ligament reconstruction; arthroscopic debridement; Article; case report; clinical article; gout; graft failure; hamstring graft; human; human tissue; hyperuricemia; joint effusion; joint limitation; joint stiffness; joint swelling; knee arthroscopy; knee instability; knee pain; knee radiography; male; muscle graft |
Dove Medical Press Ltd |
1179142X |
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Article |
Q4 |
198 |
19482 |
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687 |
Chandra R., Pudjiadi A.H., Dewi R. |
57299963800;18435202300;57190859324; |
Citrullinated Histone H3 Level as a Novel Biomarker in Pediatric Clinical Sepsis |
2021 |
Indonesian Biomedical Journal |
13 |
3 |
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316 |
323 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117346746&doi=10.18585%2finabj.v13i3.1597&partnerID=40&md5=18aa6f1cc8a9eaeff375d765e0215f81 |
Department of Child Health, Cipto Mangunkusumo Hospital/Faculty of Medicine, Universitas Indonesia, Jl. Diponegoro No.71, Jakarta, Indonesia |
Chandra, R., Department of Child Health, Cipto Mangunkusumo Hospital/Faculty of Medicine, Universitas Indonesia, Jl. Diponegoro No.71, Jakarta, Indonesia; Pudjiadi, A.H., Department of Child Health, Cipto Mangunkusumo Hospital/Faculty of Medicine, Universitas Indonesia, Jl. Diponegoro No.71, Jakarta, Indonesia; Dewi, R., Department of Child Health, Cipto Mangunkusumo Hospital/Faculty of Medicine, Universitas Indonesia, Jl. Diponegoro No.71, Jakarta, Indonesia |
Background: Sepsis is still leading cause of death in critically ill children. Early recognition of sepsis and treatments are needed to reduce its mortality. The use of citrullinated Histone H3 (Cit-H3) as an early sepsis marker and outcome predictor has been validated in previous studies among adults. However, only one study in pediatric meningococcal sepsis was reported with contradictory results. This study aims to determine Cit-H3 levels in pediatric clinical sepsis and analyze its association with sepsis severity and survival rate. METHODS: A prospective observational cohort study involving 67 pediatric subjects clinically diagnosed sepsis was conducted. Cit-H3 levels, Pediatric Logistic Organ Dysfunction-2 (PELOD-2) score, and Pediatric Sequential Organ Failure Assessment (pSOFA) score were assessed at the time of diagnosis (0-hour) and 48 hours later. Pearson Correlation test was used to determine the correlation between Cit-H3 levels with PELOD-2 andpSOFA scores and receiver operating curve to find the cutoff of Cit-H3 levels on clinical sepsis patients. RESULTS: Among clinically sepsis patients, the median Cit-H3 level was 1,210 (800-32,160) ng/mL, with optimal cut-off point ≥1200 ng/mL (sensitivity 83.3% and specificity 75.7%) to discriminate sepsis. The median Cit-H3 levels at 0-hour were lower in survivor compared to non-survivor group (p=0.016). Cit-H3 level was able to predict mortality with optimal cut-off point ≥1,200 ng/mL, sensitivity 72.2% and specificity 57.1% (AUC of 69.2%; p=0.017). Using survival analysis, Cit-H3 was significantly associated with the mortality rate (p=0.023; hazard ratio of 3.45). CONCLUSION: Cit-H3 level could be potential to predict pediatric sepsis events and its outcome. © 2021 |
citrullinated histone H3; neutrophil extracellular traps; pediatric sepsis; PELOD-2 score; pSOFA score; survival |
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Prodia Education and Research Institute |
20853297 |
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Article |
Q4 |
160 |
22228 |
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689 |
Kartika R.W., Alwi I., Suyatna F.D., Sandra F., Yunir E., Waspadji S., Immanuel S., Silalahi T., Sungkar S., Rachmat J., Bardosono S., Reksodiputro M.H. |
57223447932;15055173800;56039633100;56016164200;36520254800;8678136400;57272979000;56275255400;57016857300;6507225348;21933841000;35090488800; |
Hyaluronic Acid Accelerates VEGF and PDGF Release from Advance Platelet Rich Fibrin in Diabetic Foot Ulcer |
2021 |
Indonesian Biomedical Journal |
13 |
3 |
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332 |
336 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117336402&doi=10.18585%2finabj.v13i3.1523&partnerID=40&md5=8bff3d535a0c8b7bbd27fc12d2903eb5 |
Doctoral Program in Medical Science, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Krida Wacana Christian University, Jl. Arjuna Utara No.6, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jl. Pangeran Diponegoro No.71, Jakarta, Indonesia; Department of Clinical Pharmacology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Department of Biochemistry and Molecular Biology, Division of Oral Biology, Faculty of Dentistry, Universitas Trisakti, Jl. Kyai Tapa No. 260, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jl. Pangeran Diponegoro No.71, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Krida Wacana Christian University, Jl. Tanjung Duren Raya No.4, Jakarta, Indonesia; Department of Clinical Parasitology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Facial Plastic Reconstructive Division, Department of Otorhinolaryngology, Faculty of Medicine, Universitas Indonesia –Cipto Mangunkusumo Hospital, Jl. Pangeran Diponegoro No.71, Jakarta, Indonesia |
Kartika, R.W., Doctoral Program in Medical Science, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia, Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Krida Wacana Christian University, Jl. Arjuna Utara No.6, Jakarta, Indonesia; Alwi, I., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jl. Pangeran Diponegoro No.71, Jakarta, Indonesia; Suyatna, F.D., Department of Clinical Pharmacology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Sandra, F., Department of Biochemistry and Molecular Biology, Division of Oral Biology, Faculty of Dentistry, Universitas Trisakti, Jl. Kyai Tapa No. 260, Jakarta, Indonesia; Yunir, E., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jl. Pangeran Diponegoro No.71, Jakarta, Indonesia; Waspadji, S., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jl. Pangeran Diponegoro No.71, Jakarta, Indonesia; Immanuel, S., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jl. Pangeran Diponegoro No.71, Jakarta, Indonesia; Silalahi, T., Department of Internal Medicine, Faculty of Medicine, Krida Wacana Christian University, Jl. Tanjung Duren Raya No.4, Jakarta, Indonesia; Sungkar, S., Department of Clinical Parasitology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Rachmat, J., Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Reksodiputro, M.H., Facial Plastic Reconstructive Division, Department of Otorhinolaryngology, Faculty of Medicine, Universitas Indonesia –Cipto Mangunkusumo Hospital, Jl. Pangeran Diponegoro No.71, Jakarta, Indonesia |
Background: Hyaluronic acid (HA) is an essential component of extracellular matrix and mediates signaling in wound healing. HA could induce growth factor release from Advanced Platelet Rich Fibrin (A-PRF), including Vascular Endothelial Growth Factor (VEGF) and Platelet-derived Growth Factor (PDGF). However, concentrations of the released-VEGF and PDGF have not been clearly disclosed. Therefore, current study was conducted to measure the release of these growth factors in HA + A-PRF gel of diabetic foot ulcer (DFU) subjects. Methods: Twenty DFU subjects were included in the study and treated with A-PRF or HA+A-PRF. A-PRF was derived from autologous peripheral blood and processed with low-speed centrifugation. HA was added with a ratio of 1:0.6. A-PRF or HA + A-PRF was applied topically on DFU. Upper tips of A-PRF or HA + A-PRF gels were collected on day 0, 3 and 7 for measurements of VEGF and PDGF concentrations with Enzyme-linked Immune-sorbent Assay (ELISA) methods. Results: On day-3, both VEGF and PDGF concentrations of HA + A-PRF group were significantly higher than the VEGF (p=0.000) and PDGF (p=0.019) concentrations of A-PRF group. The VEGF and PDGF concentrations were continuously and significantly increased on day-7 of HA + A-PRF group, compared to the VEGF (p=0.000) and PDGF (p=0.004) concentrations of A-PRF group. Conclusion: Combination HA+A-PRF induces VEGF and PDGF release from A-PRF. A mixture of A-PRF and HA could be more effective than A-PRF alone for treatment of DFU. © 2021. The Indonesian Biomedical Journal. All Rights Reserved. |
advanced platelet rich fibrin; diabetic foot ulcer; growth factor; hyaluronic acid; PDGF; PRF; VEGF |
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Prodia Education and Research Institute |
20853297 |
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Article |
Q4 |
160 |
22228 |
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698 |
Susanto A.D., Rozaliyani A., Prasetyo B., Agustin H., Baskoro H., Arifin A.R., Pratama S., Zaini J., Hasto B.D., Ratmono T., Savitri A.I., Samoedro E., Husain B., Nawas A., Burhan E. |
57190425587;57203065912;57193735900;56135125000;56436836700;57223139966;57288146100;57221833355;57210897107;57288146200;56401804100;57192995312;57287062900;36490293900;36058554600; |
Epidemiological and clinical features of covid-19 patients at national emergency hospital wisma atlet kemayoran, jakarta, Indonesia |
2021 |
Kesmas |
16 |
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11 |
16 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116538242&doi=10.21109%2fkesmas.v0i0.5233&partnerID=40&md5=82245a20a3432d82a3f500c9b5968696 |
National Medical Team COVID-19, the Indonesian Society of Respirology, Jakarta, Indonesia; Department of Pulmonology and Respiratory Medicine, Persahabatan General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; National Emergency Hospital Wisma Atlet Kemayoran, Jakarta, Indonesia; Siena Clinical: Academic Research Organization, Jakarta, Indonesia |
Susanto, A.D., National Medical Team COVID-19, the Indonesian Society of Respirology, Jakarta, Indonesia, Department of Pulmonology and Respiratory Medicine, Persahabatan General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rozaliyani, A., National Medical Team COVID-19, the Indonesian Society of Respirology, Jakarta, Indonesia; Prasetyo, B., Department of Pulmonology and Respiratory Medicine, Persahabatan General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Agustin, H., Department of Pulmonology and Respiratory Medicine, Persahabatan General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Baskoro, H., National Medical Team COVID-19, the Indonesian Society of Respirology, Jakarta, Indonesia, Department of Pulmonology and Respiratory Medicine, Persahabatan General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Arifin, A.R., National Medical Team COVID-19, the Indonesian Society of Respirology, Jakarta, Indonesia, National Emergency Hospital Wisma Atlet Kemayoran, Jakarta, Indonesia; Pratama, S., National Medical Team COVID-19, the Indonesian Society of Respirology, Jakarta, Indonesia, National Emergency Hospital Wisma Atlet Kemayoran, Jakarta, Indonesia; Zaini, J., National Medical Team COVID-19, the Indonesian Society of Respirology, Jakarta, Indonesia, Department of Pulmonology and Respiratory Medicine, Persahabatan General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Hasto, B.D., National Emergency Hospital Wisma Atlet Kemayoran, Jakarta, Indonesia; Ratmono, T., National Emergency Hospital Wisma Atlet Kemayoran, Jakarta, Indonesia; Savitri, A.I., Siena Clinical: Academic Research Organization, Jakarta, Indonesia; Samoedro, E., National Medical Team COVID-19, the Indonesian Society of Respirology, Jakarta, Indonesia; Husain, B., National Medical Team COVID-19, the Indonesian Society of Respirology, Jakarta, Indonesia; Nawas, A., Department of Pulmonology and Respiratory Medicine, Persahabatan General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Burhan, E., National Medical Team COVID-19, the Indonesian Society of Respirology, Jakarta, Indonesia, Department of Pulmonology and Respiratory Medicine, Persahabatan General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
The emergency hospital is intended to prevent transmission of COVID-19 in the community by isolating patients without symptoms, with mild or moderate symptoms. This study evaluated the clinical characteristics and outcomes of COVID-19 patients who were admitted to this facility. This retrospective study re-viewed data of patients treated at the National Emergency Hospital Wisma Atlet Kemayoran in Jakarta, Indonesia, from March 23 to April 30, 2020. Patient characteristics (clinical symptoms, laboratory test results, Chest X-Ray, SARS-CoV-2 immunoserology, and RT-PCR results from nasopharyngeal/ oropharyngeal preparations) were compared between severity groups. There were 413 COVID-19 cases analyzed, of which 190 (46%) were asymptomatic, 93 (22.5%) were mild, and 130 (31.5%) were moderate cases. Most asymptomatic cases were male, with young age, and without comorbidity. Mild cases were dominated by female and young patients, while most moderate cases were male and older patients. The number of patients with comorbidities was higher in mild and mod-erate cases. The patient's overall outcome was good and did not differ based on the severity of symptoms. Despite the many challenges, patients with moderate symptoms can be safely treated in the emergency hospital. © 2021 Sciendo. All rights reserved. |
Asymptomatic; COVID-19; Emergency hospital |
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Universitas Indonesia, Faculty of public health |
19077505 |
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Article |
Q4 |
146 |
23606 |
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700 |
Rinaldi I., Prasetyawaty F., Fazlines S., Winston K., Samudera Nurrobi Y.A., Leoni J., Restu Tulus Maha I.H., Wicaksono S., Wicaksono A.Y., Aslani A.O., Ikhsani R. |
23475122400;57285017300;57284131900;57224165400;57283687900;57285017400;57285017500;57204717310;57283688000;57283914100;57283688100; |
Diagnosis and Management of Acquired Hemophilia A: Case Reports and a Literature Review |
2021 |
Case Reports in Medicine |
2021 |
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5554664 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116367653&doi=10.1155%2f2021%2f5554664&partnerID=40&md5=dd3f8e177d1b2f8c901c2f67e106f921 |
Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Rinaldi, I., Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Prasetyawaty, F., Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Fazlines, S., Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Winston, K., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Samudera Nurrobi, Y.A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Leoni, J., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Restu Tulus Maha, I.H., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wicaksono, S., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wicaksono, A.Y., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Aslani, A.O., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ikhsani, R., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background. Acquired hemophilia A (AHA) is a potentially life-threatening autoimmune hemostatic disorder where autoantibodies that disrupt the functions of factor VIII (FVIII) are present in the circulation. The early diagnosis of AHA is difficult since the symptoms of AHA differ from those of congenital hemophilia A. Furthermore, the management of AHA is also more complex due to the presence of autoantibodies against FVIII (FVIII inhibitors). Here, we present three case reports and conduct a literature review of AHA with the aim to increase awareness and knowledge regarding the diagnosis and treatment of AHA. Case Presentations. We present three patients diagnosed with AHA in these case reports. The first patient was a young female, while the second and third patients were middle-aged and elderly males, respectively. All patients presented with a chief complaint of bruises without hemarthrosis and a history of bleeding. Laboratory examinations of the patients revealed isolated prolonged aPTT, normal PT, and the presence of autoantibodies against factor VIII, which are characteristics of AHA. Patients were then treated with corticosteroids to reduce the titer level of autoantibodies and received factor VIII transfusion to stop bleeding. Conclusion. AHA can be suspected in patients presenting with symptoms of bruises without hemarthrosis and without the history of bleeding. Isolated aPTT elevation with normal PT should raise high suspicion of AHA. The presence of FVIII inhibitors can help to confirm the diagnosis of AHA. Treatment consists of factor VIII transfusion and corticosteroid therapy. Bypassing agents are recommended as an alternative to FVIII transfusion. © 2021 Ikhwan Rinaldi et al. |
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autoantibody; blood clotting factor 8; blood clotting factor 8 antibody; blood clotting factor 8 inhibitor; cyclophosphamide; fresh frozen plasma; methylprednisolone; mycophenolate mofetil; prednisone; prothrombin; recombinant blood clotting factor 8; tranexamic acid; acquired hemophilia A; activated partial thromboplastin time; adult; aged; antibody titer; bleeding; blood cell count; case report; chronic kidney failure; clinical article; contusion; corticosteroid therapy; drug dose reduction; erythrocyte concentrate; erythrocyte transfusion; female; follow up; hand swelling; hemarthrosis; hemophilia A; human; laboratory test; male; medical history; middle aged; ovariectomy; ovary cyst; physical examination; prothrombin time; Review; surgical wound; treatment duration; very elderly; young |
Hindawi Limited |
16879627 |
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Review |
Q4 |
200 |
19317 |
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709 |
Ayu Asri Prima Dewi A.A., Antarianto R.D., Pawitan J.A. |
57268721600;57190862806;6508348067; |
Characterization of indonesia decellularized liver cubes scaffold using scanning electron microscopy |
2021 |
Journal of Biomimetics, Biomaterials and Biomedical Engineering |
52 |
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38 |
46 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115446740&doi=10.4028%2fwww.scientific.net%2fJBBBE.52.38&partnerID=40&md5=c7fc1ea62d3680df39cd8c77bf963ba1 |
Master Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Central Jakarta, 10430, Indonesia; Department of Histology, Faculty of Medicine, Warmadewa University, Jl. Terompong 24 Tanjung Bungkak, Denpasar, Bali, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Central Jakarta, 10430, Indonesia; Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Central Jakarta, 10430, Indonesia; Integrated Stem Cell Technology Service Unit, Cipto Mangunkusumo National General Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia |
Ayu Asri Prima Dewi, A.A., Master Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Central Jakarta, 10430, Indonesia, Department of Histology, Faculty of Medicine, Warmadewa University, Jl. Terompong 24 Tanjung Bungkak, Denpasar, Bali, Indonesia; Antarianto, R.D., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Central Jakarta, 10430, Indonesia, Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Central Jakarta, 10430, Indonesia; Pawitan, J.A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Central Jakarta, 10430, Indonesia, Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Central Jakarta, 10430, Indonesia, Integrated Stem Cell Technology Service Unit, Cipto Mangunkusumo National General Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia |
Liver biological scaffold was developed in order to resemble native liver tissue environment. It can be achieved by decellularizing native liver tissue that will remove cells and preserve extracellular matrix (ECM). Furthermore, ECM fibers are arranged in a special pattern, which affect liver cell polarity and topography that are important for cells’ implantation, proliferation and differentiation. Therefore, the aim of this study was to evaluate liver cube scaffold topography that was decellularized with fixed multiple sites syringe injection (Indonesia patent number: S00201907930). Rat liver cubes (n=3) underwent decellularization with Ethylene Glycol Tetraacetic Acid (EGTA) immersion and increased Sodium Dodecyl Sulfate (SDS) concentrations using previous multiple sites syringe injection protocol study. Deoxyribonucleic Acid (DNA) concentrations were measured to confirm less DNA materials remaining in scaffolds. Scanning Electron Microscope (SEM) analysis of scaffolds were conducted for topographic characterization compared to undecellularized liver control. Molecular analysis of DNA concentration showed complete removal of DNA material. SEM analysis gave appearance of intact liver cube scaffold microarchitecture. Liver cubes decellularization using multiple sites syringe injection showed good topographic liver scaffold characterization. © 2021 Trans Tech Publications Ltd, Switzerland. |
Liver biological scaffold; Liver cube tissue; Liver decellularization; Multiple site syringe injection; Scanning electron microscope |
Cytology; DNA; Ethylene; Ethylene glycol; Geometry; Scaffolds (biology); Sodium dodecyl sulfate; Sulfur compounds; Syringes; Tissue; Acid concentrations; Biological scaffolds; Decellularization; Extracellular matrices; Indonesia; Liver biological scaffold; Liver cube tissue; Liver decellularization; Liver tissue; Multiple site syringe injection; Scanning electron microscopy |
Trans Tech Publications Ltd |
22969837 |
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Article |
Q4 |
183 |
20493 |
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