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891 |
Soetisna T.W., Buana A.C., Tirta E.S., Ardiyan A., Aligheri D., Herlambang B., Tjubandi A., Hanafy D.A., Sugisman S. |
57214887740;57221743134;57221753958;57212102199;57221752393;36468390900;57211055979;57220157579;57221747222; |
A 48-year-old man at low risk for SARS-CoV-2 infection who underwent planned elective triple-vessel coronary artery bypass graft surgery at a national heart center in indonesia followed by a fatal case of COVID-19 |
2021 |
American Journal of Case Reports |
22 |
1 |
e928900 |
1 |
5 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100047943&doi=10.12659%2fAJCR.928900&partnerID=40&md5=a033f16e0dbe64b1b4c3e7d6f2d25ab7 |
Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Department of Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Surgery, Faculty of Medicine, University Syiah Kuala, Banda Aceh, Indonesia; Department of Surgery, Faculty of Medicine, University Krida Wacana, Jakarta, Indonesia; Department of Anesthesiologist and Intensive Therapy, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Department of Anesthesiologist and Intensive Therapy, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Soetisna, T.W., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Buana, A.C., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Surgery, Faculty of Medicine, University Syiah Kuala, Banda Aceh, Indonesia; Tirta, E.S., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Surgery, Faculty of Medicine, University Krida Wacana, Jakarta, Indonesia; Ardiyan, A., Department of Anesthesiologist and Intensive Therapy, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Anesthesiologist and Intensive Therapy, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Aligheri, D., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Herlambang, B., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Tjubandi, A., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Hanafy, D.A., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Sugisman, S., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Patient: Male, 48-year-old Final Diagnosis: Chronic kidney disease • coronary artery disease • COVID-19 Symptoms: Chest pain • fever • shorthness of breath Medication: — Clinical Procedure: Coronary artery bypass graft surgery Specialty: Cardiac surgery Objective: Background: Case Report: Conclusions: Rare co-existance of disease or pathology This is of the first fatal case of coronavirus disease 2019 (COVID-19) pneumonia at a National Heart Center in Indonesia following planned elective triple-vessel coronary artery bypass graft (CABG) who was considered to be at low risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection when admitted for surgery. A 48-year-old man was diagnosed with coronary artery disease (CAD) in 3 vessels (3VD) with an ejection fraction (EF) of 61% and chronic kidney disease (CKD) with routine hemodialysis. The patient was scheduled for a coronary artery bypass graft (CABG) surgery. He underwent surgery after COVID-19 screening using a checklist provided by the hospital. The patient’s condition worsened on the 3rd postoperative day in the ward, and he was transferred back to the Intensive Care Unit (ICU), reintubated, and tested for COVID-19 with a real time-polymerase chain reaction (PCR) test. Because of the COVID-19 pandemic, we excluded the other possible pneumonia causes (e.g., influenza). An RT-PCR test performed after surgery revealed that the patient was positive for COVID-19. COVID-19 tracing was performed for all health care providers and relatives; all results were negative except for 1 family member. The patient was treated for 4 days in the isolation ICU but died due to complications of the infection. This report shows the importance of testing patients for SARS-CoV-2 infection before hospital admission for elective surgery and during the hospital stay, and the importance of developing rapid and accurate testing methods that can be used in countries and centers with limited health resources. © Am J Case Rep, 2021;. |
Coronary artery bypass; Coronary artery disease; COVID-19 |
bicarbonate; carbon dioxide; creatine kinase MB; creatinine; oxygen; urea; adult; anemia; angina pectoris; Article; bicarbonate blood level; blood carbon dioxide tension; blood oxygen tension; body mass; cardiomegaly; case report; cerebrovascular accident; chronic kidney failure; clinical article; comorbidity; contact examination; continuous renal replacement therapy; coronary angiography; coronary artery bypass graft; coronary artery disease; coronavirus disease 2019; creatine kinase blood level; creatinine blood level; deterioration; disease exacerbation; dyslipidemia; dyspnea; elective surgery; emergency surgery; emergency ward; fatality; fever; health care personnel; heart center; heart ejection fraction; hemodialysis; high risk patient; hospital admission; human; Indonesia; infection |
International Scientific Information, Inc. |
19415923 |
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33487629 |
Article |
Q3 |
247 |
16822 |
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892 |
Dwinata M., Putera D.D., Hasan I., Raharjo M. |
57209231012;57210288025;12776850800;57212400550; |
SGLT2 inhibitors for improving hepatic fibrosis and steatosis in non-alcoholic fatty liver disease complicated with type 2 diabetes mellitus: a systematic review |
2021 |
Clinical and Experimental Hepatology |
6 |
4 |
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339 |
346 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099931230&doi=10.5114%2fceh.2020.102173&partnerID=40&md5=628a477d8f6d02f9de989db2ce816c8c |
Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Hepatobiliary Division, Department of Internal Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Dwinata, M., Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Putera, D.D., Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Hasan, I., Hepatobiliary Division, Department of Internal Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Raharjo, M., Hepatobiliary Division, Department of Internal Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Aim of the study: To evaluate the efficacy of sodium/glucose cotransporter-2 inhibitors (SGLT2i) in improving hepatic fibrosis and steatosis of non-alcoholic fatty liver disease (NAFLD) patients with type 2 diabetes mellitus (T2DM). Material and methods: We searched CENTRAL, MEDLINE, and EMBASE and included any clinical trials involving patients with NAFLD and T2DM aged ≥ 18 years comparing efficacy of SGLT2i and other antidiabetic drugs in improving fibrosis and steatosis, irrespective of publication status, year of publication, and language. Results: Five clinical trials were included. One study reported significant improvements in the controlled attenuation parameter 314.6 ±61.0 dB/m to 290.3 ±72.7 dB/m (p = 0.04) in the SGLT2i group measured by transient elastography. In patients with significant fibrosis, dapagliflozin treatment significantly decreased the liver stiffness measurement from 14.7 ±5.7 kPa at baseline to 11.0 ±7.3 kPa after 24 weeks (p = 0.02). One study reported a significant decrease in liver fat content 16.2% to 11.3% (p < 0.001) in the SGLT2i group compared to the control (p < 0.001). Three studies reported significant improvement in the liver-to-spleen ratio in the SGLT2i group after treatment 0.96 (0.86-1.07) to 1.07 (0.98-1.14), p < 0.01, 0.80 ±0.24 to 1.00 ±0.18, p < 0.001, and 0.91 (0.64-1.04) to 1.03 (0.80-1.20), p < 0.001 respectively. All studies reported a significant decrease in alanine aminotransferase with SGLT2i. Conclusions: SGLT2i is associated with positive effects on hepatic steatosis measured by non-invasive modalities. Further studies are needed to confirm the impact of SGLT2i on hepatic fibrosis and steatosis. © 2020 Termedia Publishing House Ltd.. All rights reserved. |
Diabetes mellitus; Fibrosis; NAFLD; SGLT2 inhibitor; Steatosis |
alanine aminotransferase; dapagliflozin; empagliflozin; ipragliflozin; luseogliflozin; metformin; pioglitazone; sodium glucose cotransporter 2 inhibitor; adult; aged; alanine aminotransferase blood level; Article; comparative effectiveness; controlled study; diabetic patient; drug efficacy; elastography; female; human; liver fibrosis; liver stiffness; major clinical study; male; middle aged; non insulin dependent diabetes mellitus; nonalcoholic fatty liver; quasi experimental study; randomized controlled trial; systematic review; transient elastography; treatment outcome |
Termedia Publishing House Ltd. |
23921099 |
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Article |
Q4 |
394 |
12273 |
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893 |
Alkaff F.F., Illavi F., Salamah S., Setiyawati W., Ramadhani R., Purwantini E., Tahapary D.L. |
57208781930;57221732812;57217109015;57221720254;57219870814;57221736394;55944492500; |
The Impact of the Indonesian Chronic Disease Management Program (PROLANIS) on Metabolic Control and Renal Function of Type 2 Diabetes Mellitus Patients in Primary Care Setting |
2021 |
Journal of Primary Care and Community Health |
12 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099918670&doi=10.1177%2f2150132720984409&partnerID=40&md5=6ba221c547d10bfc27fa5120aa56a223 |
Department of Pharmacology and Therapy, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia; Department of Internal Medicine, Dr.Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Central Jakarta, Jakarta, Indonesia; Department of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia; Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia; Politeknik Elektronika Negeri Surabaya, Surabaya, East Java, Indonesia; Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Central Jakarta, Jakarta, Indonesia |
Alkaff, F.F., Department of Pharmacology and Therapy, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia; Illavi, F., Department of Internal Medicine, Dr.Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Central Jakarta, Jakarta, Indonesia; Salamah, S., Department of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia; Setiyawati, W., Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia; Ramadhani, R., Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia; Purwantini, E., Politeknik Elektronika Negeri Surabaya, Surabaya, East Java, Indonesia; Tahapary, D.L., Department of Internal Medicine, Dr.Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Central Jakarta, Jakarta, Indonesia, Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Central Jakarta, Jakarta, Indonesia |
Background: Indonesia through its government National Health Insurance System has launched a non-communicable and chronic disease management program named Indonesian Chronic Disease Management Program (PROLANIS), with Type 2 Diabetes Mellitus (T2DM) and hypertension as the main focus. However, study that evaluates the clinical impact of PROLANIS in patients with T2DM is still scarce to this date. This study aims to evaluate the metabolic control and renal function of PROLANIS participants with T2DM every six month within the first 18-months of implementation. Methods: This study was a retrospective cohort study conducted at Wates sub-district, East Java using secondary data from PROLANIS group report from April 2018 to October 2019. The study population was T2DM patients who voluntarily joined the PROLANIS group in April 2018. The six-month-evaluation included metabolic parameters [body mass index (BMI), blood pressure, hemoglobin A1C, total cholesterol, high-density lipid, low-density lipid, and triglyceride (TG)] and renal parameters [blood urea nitrogen (BUN), creatinine serum, and urinary microalbumin]. Paired t-test and wilcoxon signed-rank test was used for the analysis, and the P-value was adjusted using Bonferroni correction. A P-value <.0015 was considered statistically significant, while a P-value between.0015 and.003 was considered as marginally significant. Results: A total of 30 participants were included in the analysis. Following the PROLANIS implementation, the only parameter of metabolic control that showed significant improvement was TG serum level (P <.001). Despite the worsening status of other metabolic parameters, the changes were not statistically significant except for BMI that was marginally significant (P =.002). From renal function, only BUN serum level was significantly deteriorated (P <.001), while the others did not significantly change. Conclusion: PROLANIS implementation in our study population seems to be ineffective. Future study with more primary healthcare centers needs to be done to scrutinize the clinical impact of this program nationwide. © The Author(s) 2021. |
government program; Indonesia; primary healthcare; PROLANIS; type 2 diabetes mellitus |
glycosylated hemoglobin; disease management; human; Indonesia; non insulin dependent diabetes mellitus; primary health care; retrospective study; Diabetes Mellitus, Type 2; Disease Management; Glycated Hemoglobin A; Humans; Indonesia; Primary Health Care; Retrospective Studies |
SAGE Publications Inc. |
21501319 |
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33472499 |
Article |
Q2 |
550 |
9179 |
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894 |
Sandhiutami N.M.D., Arozal W., Louisa M., Rahmat D. |
56692904000;32067462200;41461551400;36673726800; |
Determine Curcumin Concentration in Organ Rats and in Ovaries at Ovarian Cancer Model Rats Using Ultra Performance Liquid Chromatography-Mass Spectrometry (Ms)/Ms |
2021 |
Pharmaceutical Sciences Asia |
48 |
1 |
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37 |
45 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099915596&doi=10.29090%2fPSA.2021.02.19.146&partnerID=40&md5=59970a9906f368c7cd760cdd0765143e |
Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Sandhiutami, N.M.D., Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia; Arozal, W., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahmat, D., Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia |
Curcumin has several pharmacological effects including anti-inflammatory, reduce kidney damage, hepatoprotector, and inhibiting tumor growth in ovarian cancer. The use of curcumin is limited because it has low bioavailability and low capacity to reach target organs. This limitation is overcome by making it in the form of nanoparticles. This study aim to determine curcumin levels on some organ in healthy rat groups and on ovaries at ovarian cancer models rat that given curcumin and curcumin nanoparticles. Measurement of curcumin levels using UPLC-MS/MS. Determination of curcumin level in the organ was carried out in 2 treatment groups, group that received curcumin and group that received curcumin nanoparticles orally with a single dose of 100 mg/kg Body Weight (BW). At 180 minutes, rats were decapitated for liver, kidney and ovaries. The ovarian cancer rats were also divided into 2 groups and given curcumin and curcumin nanoparticles with repeated doses of 100 mg/kgBW/day and after 30 days, ovarian cancer rats were decapitated for the ovaries. In the group that received curcumin, the concentration of curcumin in the liver, kidney and ovaries were less than the detection limit, whereas in the group that received curcumin nanoparticles, the levels of curcumin are 1,866.6±22.60 ng/g in liver, 114.87±13.36 ng/g in kidney and 136.864±11.15 ng/g in ovaries. In ovarian cancer rats, levels of curcumin in the group receiving curcumin is 2.29±1.15 ng/g and 17.76±4.85 ng/g in the group receiving curcumin nanoparticles. Curcumin nanoparticles can increase the distribution of curcumin in liver, kidney, ovaries in healthy rats and in ovaries at ovarian cancer model rats. © 2020. All Rights Reserved. |
curcumin; curcumin nanoparticles; ovarian cancer rats; rats organ; UPLC MS/MS |
curcumin; nanoparticle; animal experiment; animal model; animal tissue; Article; cancer model; controlled study; drug determination; drug distribution; drug liver level; female; kidney homogenate; limit of detection; limit of quantitation; liquid chromatography-mass spectrometry; liver homogenate; measurement accuracy; measurement precision; nonhuman; ovary; ovary cancer; rat; repeated drug dose; single drug dose |
Mahidol University - Faculty of Pharmacy |
25868195 |
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Article |
Q3 |
144 |
23834 |
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895 |
Tarigan T.J.E., Dwijayanti A., Setyowati S., Louisa M. |
36057746500;55743787900;54893136300;41461551400; |
Immunogenicity and efficacy of insulin glargine biosimilar ezelin versus originator insulin glargine in patients with type 2 diabetes |
2021 |
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy |
14 |
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107 |
116 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099828801&doi=10.2147%2fDMSO.S279385&partnerID=40&md5=4adefbb901a3483328866d6334ab8e3d |
Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Endocrinology, Department of Internal Medicine, Gatot Soebroto Presidential Hospital, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Tarigan, T.J.E., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Dwijayanti, A., Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setyowati, S., Division of Endocrinology, Department of Internal Medicine, Gatot Soebroto Presidential Hospital, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Purpose: To compare the immunogenicity and efficacy of insulin glargine biosimilar Ezelin (EZL) versus originator insulin glargine Lantus (LAN) as a reference basal insulin in patients with type 2 diabetes (T2D). Patients and Methods: This was a randomized, multicenter, open-label, 24-week study in insulin-naïve patients with T2D, with HbA1c of >7.0%. We randomly assigned 133 eligible patients to receive either EZL or LAN. Baseline characteristics, including insulin autoantibody (IAA), zinc transporter 8 (ZnT8) antibody, HbA1C, fasting plasma glucose (FPG), 2-hour postprandial plasma glucose (2hPPG), AST, ALT, BUN, eGFR, and oral antidiabetic drugs, were obtained before starting insulin treatment. After starting treatment, insulin dose was titrated to achieve FPG target along with oral antidiabetic drugs. Patients were given home glucometer and assisted to record plasma glucose measurement and adverse event (AE). Every month, patients came to the diabetes clinic and performed a regular physical examination and intensifying treatment if needed. Out of the 133 randomized patients, only 122 completed the study and can be examined for their IAA and ZnT8 after 6 months of treatment. The study was registered in clinicaltrials.gov, NCT03352674. Results: There is a similar proportion of patients with changes of IAA from baseline: 1 out of 58 (1.7%) patients receiving EZL versus 1 out of 64 (1.6%) patients receiving LAN (p = 1.000). One patient in the EZL group (1.7%) versus none in the LAN group experienced a change of ZnT8 antibody from baseline. Similar glucose control in EZL versus LAN was determined by the change in HbA1c, FPG, and 2hPPG (−2.0%, −67.46 mg/dL, and −76.51 mg/dL in the EZL group versus −1.7%, −58.11 mg/dL, and −70.03 mg/dL in the LAN group). There were six events of documented hypoglycemia in the EZL group versus five events in the LAN group. No patients experienced diabetic ketoacidosis during the study. Conclusion: Overall, insulin glargine biosimilar EZL and originator insulin glargine LAN have shown a similar immunogenicity profile, as well as efficacy in providing glucose control and safety findings in T2D populations. © 2021 Tarigan et al. |
Biosimilar; Hyperglycemia; Insulin autoantibody; Zinc transporter 8 antibody |
acarbose; alanine aminotransferase; aspartate aminotransferase; ezelin; glucose; hemoglobin A1c; insulin antibody; insulin glargine; metformin; pioglitazone; protein antibody; sulfonylurea; unclassified drug; urea; zinc transporter 8; zinc transporter 8 antibody; acute gastroenteritis; acute kidney failure; adult; alanine aminotransferase blood level; Article; aspartate aminotransferase blood level; Bell palsy; cardiovascular disease; cerebrovascular accident; cervical spine fracture; controlled study; coughing; dermatitis; diabetic ketoacidosis; diabetic patient; diabetic ulcer; diarrhea; drug dose titration; drug efficacy; drug safety; dyspepsia; dyspnea; estimated glomerular filtration rate; fasting; female; gangrene; gastritis; gastroesophageal reflux; gastrointestinal symptom; glucose |
Dove Medical Press Ltd |
11787007 |
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Article |
Q2 |
853 |
5525 |
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896 |
Suraya A., Nowak D., Sulistomo A.W., Icksan A.G., Berger U., Syahruddin E., Bose-O’reilly S. |
57214135787;7201764407;57024018500;57194332884;7101876991;6507688750;55933417800; |
Excess risk of lung cancer among agriculture and construction workers in Indonesia |
2021 |
Annals of Global Health |
87 |
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1 |
14 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099767907&doi=10.5334%2faogh.3155&partnerID=40&md5=01b5a6cafe172bcea089864226c539b6 |
CIHLMU Center for International Health, University Hospital, LMU, Munich, Germany; Universitas Binawan, Jakarta, Indonesia; Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, LMU University Hospital, Munich, Germany; Comprehensive Pneumology Center Munich (CPC-M), Member, German Center for Lung Research (DZL), Germany; Department of Radiology, Persahabatan Hospital, National Respiratory Referral Hospital, Jakarta, Indonesia; Faculty of Medicine UPN Veteran, Jakarta, Indonesia; IBE – Institute for Medical Information Processing, Biometry and Epidemiology, LMU, Munich, Germany; Division of Thoracic Oncology Department of Pulmonology Faculty of Medicine, Universitas Indonesia Persahabatan hospital, Jakarta, Indonesia; Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, LMU University Hospital, Munich, Germany; Institute of Public Health, Medical Decision Making and Health Technology Assessment, Department of Public Health, Health Services Research and Health Technology Assessment, UMIT–Private University for Health Sciences, Medical Informatics and Technology, Austria |
Suraya, A., CIHLMU Center for International Health, University Hospital, LMU, Munich, Germany, Universitas Binawan, Jakarta, Indonesia; Nowak, D., Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, LMU University Hospital, Munich, Germany, Comprehensive Pneumology Center Munich (CPC-M), Member, German Center for Lung Research (DZL), Germany; Sulistomo, A.W., Universitas Binawan, Jakarta, Indonesia; Icksan, A.G., Department of Radiology, Persahabatan Hospital, National Respiratory Referral Hospital, Jakarta, Indonesia, Faculty of Medicine UPN Veteran, Jakarta, Indonesia; Berger, U., IBE – Institute for Medical Information Processing, Biometry and Epidemiology, LMU, Munich, Germany; Syahruddin, E., Division of Thoracic Oncology Department of Pulmonology Faculty of Medicine, Universitas Indonesia Persahabatan hospital, Jakarta, Indonesia; Bose-O’reilly, S., Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, LMU University Hospital, Munich, Germany, Institute of Public Health, Medical Decision Making and Health Technology Assessment, Department of Public Health, Health Services Research and Health Technology Assessment, UMIT–Private University for Health Sciences, Medical Informatics and Technology, Austria |
Background: In Indonesia, many occupations and industries involve a variety of hazardous and toxic materials. The ILO estimates that about 21.1% of the tracheal, bronchial, and lung cancer deaths among men were attributable to workplace hazardous substances. This study investigated the relationship between occupations or workplace exposure and the risk of lung cancer in the country. The results will help determine how Indonesia can best mitigate the risk for its workers. Objectives: This case-control study utilizes the Indonesian Standard of Industrial Classification (IndSIC) 2015 with the aim of exploring the risk of lung cancer among Indonesian workers. Methods: The study included patients aged 35 years old or older receiving thoracic CT at the radiology department of Persahabatan Hospital. The cases were histologicalconfirmed primary lung cancers, while the controls were negative thoracic CT scan for lung cancer. The subjects’ job titles and industries were classified according to IndSIC 2015 and blind to the patient’s grouping as a case or control. Logistic regression was used to determine the odds ratios for lung cancer among all sections and some divisions or groups of IndSIC 2015. Findings: The mean age was 58.1 (±10.23) years for lung cancer patients and 54.5 (±10.23) years for controls. The majority of subjects (19.6%) worked in Section G (Wholesale and retail trade; repair of motor vehicles and motorcycle). After adjusting for age, gender, level of education, and smoking habit, the risk of lung cancer was nearly three-times higher (OR = 2.8, 95% CI = 1.11–7.02) in workers of Division A01 (crop, animal production, and hunting) and two-times higher (OR = 1.9, 95% CI = 1.05–3.46) in workers of Section F (construction) compared to the workers in other sections or divisions. Conclusions: The excess risk of lung cancer among certain categories of workers confirms the need for improved policy, monitoring, and control of occupational exposure for primary cancer prevention and workers’ compensation purposes. © 2021 The Author(s). |
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adult; aged; agricultural worker; Article; cancer prevention; cancer risk; case control study; construction worker; controlled study; educational status; female; human; human tissue; Indonesia; lung cancer; major clinical study; male; medical information; motor vehicle; motorcycle; occupational exposure; occupational health; smoking habit; x-ray computed tomography; adverse event; agriculture; building industry; lung tumor; middle aged; occupation; occupational disease; occupational exposure; risk factor; very elderly; Adult; Aged; Aged, 80 and over; Agriculture; Case-Control Studies; Construction Industry; Female; Humans; Indonesia; Lung Neoplasms; Male; Middle Aged; Occupational Diseases; Occupational Exposure; Occupations; Risk Factors |
Ubiquity Press |
22149996 |
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33505867 |
Article |
Q2 |
602 |
8385 |
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897 |
Oshima T., Siah K.T.H., Kim Y.S., Patcharatrakul T., Chen C.-L., Mahadeva S., Park H., Chen M.-H., Lu C.-L., Hou X., Quach D.T., Syam A.F., Rahman M.M., Xiao Y., Jinsong L., Chua A.S.B., Miwa H. |
7401663152;35757936600;57196171210;8549899200;23495616400;6602694336;56255219600;57216452428;7404805612;57210061408;37099075800;8443384400;57216556340;23500436000;57221693058;7004518894;56921458500; |
Knowledge, attitude, and practice survey of gastroparesis in asia by asian neurogastroenterology and motility association |
2021 |
Journal of Neurogastroenterology and Motility |
27 |
1 |
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46 |
54 |
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5 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099728456&doi=10.5056%2fJNM20117&partnerID=40&md5=49d79381fdad1a0dca816161fd54b8e0 |
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore, Singapore; Digestive Disease Research Institute, School of Medicine, Wonkwang University, Iksan, Jeollabuk-do, South Korea; Center of Excellence in Neurogastroenterology and Motility, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Division of Gastroenterology, Department of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand; Department of Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien, Taiwan; Institute of Medical Sciences, College of Medicine, Tzu Chi University, Hualien, Taiwan; Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University, Seoul, South Korea; Department of Gastroenterology and Hepatology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Endoscopy Center for Diagnosis and Treatment, Taipei Veterans General Hospital, Taipei, Taiwan; Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Internal Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh, Viet Nam; Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta Pusat, Indonesia; Department of Gastroenterology, Sheikh Russel National Gastroliver Institute and Hospital, Dhaka, Bangladesh; Gastro Center Ipoh, Ipoh, Malaysia |
Oshima, T., Division of Gastroenterology and Hepatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan; Siah, K.T.H., Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore, Singapore; Kim, Y.S., Digestive Disease Research Institute, School of Medicine, Wonkwang University, Iksan, Jeollabuk-do, South Korea; Patcharatrakul, T., Center of Excellence in Neurogastroenterology and Motility, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, Division of Gastroenterology, Department of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand; Chen, C.-L., Department of Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien, Taiwan, Institute of Medical Sciences, College of Medicine, Tzu Chi University, Hualien, Taiwan; Mahadeva, S., Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Park, H., Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University, Seoul, South Korea; Chen, M.-H., Department of Gastroenterology and Hepatology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Lu, C.-L., Endoscopy Center for Diagnosis and Treatment, Taipei Veterans General Hospital, Taipei, Taiwan; Hou, X., Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Quach, D.T., Department of Internal Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh, Viet Nam; Syam, A.F., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta Pusat, Indonesia; Rahman, M.M., Department of Gastroenterology, Sheikh Russel National Gastroliver Institute and Hospital, Dhaka, Bangladesh; Xiao, Y., Department of Gastroenterology and Hepatology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Jinsong, L., Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Chua, A.S.B., Gastro Center Ipoh, Ipoh, Malaysia; Miwa, H., Division of Gastroenterology and Hepatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan |
Background/Aims Gastroparesis is identified as a subject that is understudied in Asia. The scientific committee of the Asian Neurogastroenterology and Motility Association performed a Knowledge, Attitude, and Practices survey on gastroparesis among doctors in Asia. Methods The questionnaire was created and developed through a literature review of current gastroparesis works of literature by the scientific committee of Asian Neurogastroenterology and Motility Association. Results A total of 490 doctors from across Asia (including Bangladesh, China, Hong Kong, Indonesia, Japan, Malaysia, Myanmar, the Philippines, Singapore, South Korea, Taiwan, Thailand, and Vietnam) participated in the survey. Gastroparesis is a significant gastrointestinal condition. However, a substantial proportion of respondents was unable to give the correct definition and accurate diagnostic test. The main reason for lack of interest in diagnosing gastroparesis was "the lack of reliable diagnostic tests"(46.8%) or "a lack of effective treatment"(41.5%). Only 41.7% of respondents had access to gastric emptying scintigraphy. Most doctors had never diagnosed gastroparesis at all (25.2%) or diagnosed fewer than 5 patients a year (52.1%). Conclusions Gastroparesis can be challenging to diagnose due to the lack of instrument, standardized method, and paucity of research data on normative value, risk factors, and treatment studies in Asian patients. Future strategies should concentrate on how to disseminate the latest knowledge of gastroparesis in Asia. In particular, there is an urgent need to estimate the magnitude of the problems in high risk and idiopathic patients as well as a standardized diagnostic procedure in Asia. © 2021 The Korean Society of Neurogastroenterology and Motility. |
Asia; Dyspepsia; Gastroparesis; Health care surveys; Health education |
Article; Asia; Bangladesh; China; demography; diagnostic test; female; Hong Kong; human; Indonesia; Japan; knowledge; Malaysia; male; medical society; Myanmar; Philippines; physician attitude; questionnaire; scintigraphy; Singapore; South Korea; stomach emptying; stomach paresis; Taiwan; test meal; Thailand; Viet Nam |
Korean Society of Neurogastroenterology and Motility |
20930879 |
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Article |
Q1 |
1345 |
2715 |
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898 |
Dewi B.E., Nainggolan L., Sudiro T.M., Chenderawasi S., Goentoro P.L., Sjatha F. |
24076058600;23498394800;6506414225;57221643087;57212515515;55372815000; |
Circulation of various dengue serotypes in a community-based study in Jakarta, Indonesia |
2021 |
Japanese Journal of Infectious Diseases |
74 |
1 |
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17 |
22 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099705269&doi=10.7883%2fyoken.JJID.2019.431&partnerID=40&md5=d7c98adae43cb2a3728e97343d353000 |
Department of Microbiology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Departement of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Community Based Dengue Study, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Cluster of Infectious Diseases and Immunology, Indonesian Medical Education and Research Institute (IMERI), Jakarta, Indonesia |
Dewi, B.E., Department of Microbiology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Community Based Dengue Study, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Cluster of Infectious Diseases and Immunology, Indonesian Medical Education and Research Institute (IMERI), Jakarta, Indonesia; Nainggolan, L., Departement of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Community Based Dengue Study, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sudiro, T.M., Department of Microbiology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Cluster of Infectious Diseases and Immunology, Indonesian Medical Education and Research Institute (IMERI), Jakarta, Indonesia; Chenderawasi, S., Community Based Dengue Study, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Goentoro, P.L., Community Based Dengue Study, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sjatha, F., Department of Microbiology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Cluster of Infectious Diseases and Immunology, Indonesian Medical Education and Research Institute (IMERI), Jakarta, Indonesia |
Dengue virus (DENV) infection remains to be a serious health problem in Indonesia. Community-based dengue studies to determine circulating DENV serotypes based on the geography and season are limited owing to the expensive cost and significant effort required. Many patients with DENV infection are not hospitalized and many visit the hospital in the later phase of the disease. In this study, we performed active DENV surveillance in a community in Jakarta to study the circulating dengue serotypes; adult febrile patients with fever less than 48 hours were recruited. Disease severity was defined using the World Health Organization (WHO) 1997 guidelines. Rapid NS1 dengue antigen detection was used to screen patients with DENV in the community. Viral culture using the C6/36 cell line, an increased antibody titer on hemagglutination inhibition test and enzyme linked immunosorbent assay, or detection of the viral genome on reverse transcription-polymerase chain reaction was used to confirm DENV infection. Of the 102 patients, 68 (66.7%) were confirmed to have DENV infection, with DENV-2 being the most dominant serotype, followed by DENV-3, DENV-1, and DENV-4, in concordance with several reports of mixed DENV infection. Interestingly, in terms of disease severity, although DENV-3 infection was not the predominant circulating serotype, infection with it tended to cause a more severe disease than infection with DENV-2. © 2021, National Institute of Health. All rights reserved. |
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DNA polymerase; nonstructural protein 1; viral protein; virus antibody; adult; antibody titer; antigen detection; Article; Dengue virus; disease severity; enzyme linked immunosorbent assay; female; fever; hemagglutination inhibition test; human; human cell; Indonesia; major clinical study; male; monitoring; reverse transcription polymerase chain reaction; serotype; virus culture; virus genome; World Health Organization; adolescent; dengue; Dengue virus; genetics; isolation and purification; middle aged; molecular epidemiology; severity of illness index; virology; young adult; Adolescent; Adult; Antibodies, Viral; Dengue; Dengue Virus; Enzyme-Linked Immunosorbent Assay; Female; Genome, Viral; Humans; Indonesia; Male; Middle Aged; Molecular Epidemiology; Reverse Transcriptase Polymerase Chai |
National Institute of Health |
13446304 |
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32611971 |
Article |
Q3 |
517 |
9793 |
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899 |
Tanto I.V., Dharma S., Juzar D.A., Bono A.A.H. |
57221612652;55101301700;55358712500;57208146721; |
Ventricular Septal Rupture Complicating an Acute ST-Segment Elevation Myocardial Infarction during the COVID-19 Pandemic |
2021 |
International Journal of Angiology |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099596441&doi=10.1055%2fs-0040-1720971&partnerID=40&md5=aab866db219c647750534315d55f3fdf |
Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jl S Parman Kav 87, Slipi, Jakarta Barat, Jakarta, 11420, Indonesia; Division of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
Tanto, I.V., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jl S Parman Kav 87, Slipi, Jakarta Barat, Jakarta, 11420, Indonesia; Dharma, S., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jl S Parman Kav 87, Slipi, Jakarta Barat, Jakarta, 11420, Indonesia; Juzar, D.A., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jl S Parman Kav 87, Slipi, Jakarta Barat, Jakarta, 11420, Indonesia; Bono, A.A.H., Division of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
Ventricular septal rupture (VSR) is rare but a lethal complication of acute myocardial infarction (MI). Definite treatment requires the surgical closure of the VSR and coronary artery bypass grafting (CABG). However, the optimal timing for surgery is still controversial, particularly during the novel coronavirus disease 2019 (COVID-19) pandemic where medical procedures should be performed within the safest environment. Before surgery, a proper management in the intensive cardiovascular care unit is essential to maintain the stability of the hemodynamic profile related with VSR and determines the prognosis of the patient. We described a case of VSR complicating an anterior wall MI in a patient who admitted to our hospital during the COVID-19 pandemic that was treated successfully by surgical closure of the VSR and CABG. © 2021 BMJ Publishing Group. All rights reserved. |
bypass grafting; myocardial infarction; surgical repair; ventricular septal rupture |
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Thieme Medical Publishers, Inc. |
10611711 |
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Article |
Q3 |
293 |
15070 |
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900 |
Pulungan A.B., Fadiana G., Annisa D. |
57192905981;57221614963;57205770955; |
Type 1 diabetes mellitus in children: Experience in Indonesia |
2021 |
Clinical Pediatric Endocrinology |
30 |
1 |
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11 |
18 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099564628&doi=10.1297%2fcpe.30.11&partnerID=40&md5=aba5de1c98be7c8ac4cc9cdd9a7ff21b |
Child Health Department, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Pulungan, A.B., Child Health Department, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Fadiana, G., Child Health Department, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Annisa, D., Child Health Department, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
The prevalence of type 1 diabetes mellitus (T1DM) in children in Indonesia is increasing although the real number is unknown due to high rate of misdiagnosis. Public and healthcare awareness on T1DM in children is still low, reflected by the high number of children diagnosed with diabetic ketoacidosis (DKA). The Indonesian Pediatric Society (IPS) had published a guideline on T1DM management, which consists of insulin injection, daily monitoring of blood glucose, nutrition, physical activity, and education. Aside from low awareness, current challenges on T1DM management in Indonesia are funding by the national health insurance, fasting during Ramadan, and inequities on DM care. The involvement of society, healthcare workers, stakeholders, and the government is of importance to ensure optimal management for children with diabetes. © 2021 by The Japanese Society for Pediatric Endocrinology. |
Children; Diabetes; Indonesia; Type 1 diabetes mellitus (T1DM) |
hemoglobin A1c; immunologic factor; insulin; vitamin D; awareness; blood glucose monitoring; blurred vision; body mass; body weight loss; caloric intake; carbohydrate intake; clinical article; diabetic ketoacidosis; diabetic retinopathy; education; endocrinologist; epigenetics; food intake; glucose blood level; glycemic control; health care personnel; health insurance; health survey; human; hyperglycemia; hyperphagia; hypertension; hypocalcemia; hypoglycemia; insulin dependent diabetes mellitus; insulin resistance; insulin sensitivity; insulin treatment; insulinoma; ketoacidosis; ketonuria; metabolic regulation; microalbuminuria; national health insurance; nocturia; non insulin dependent diabetes mellitus; nutrition; obesity; oral glucose tolerance test; pediatrician; physical activity; po |
Jeff Corporation Co. Ltd |
09185739 |
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