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No records
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731 |
Raharjo D.E., Kunadian V. |
57212958767;55390915800; |
Is There a Difference in Efficacy of Percutaneous Coronary Intervention for Focal and Diffuse Stable Coronary Artery Disease? |
2021 |
Circulation: Cardiovascular Interventions |
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011013 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113224581&doi=10.1161%2fCIRCINTERVENTIONS.121.011013&partnerID=40&md5=d51bf48934551b00e2a6df5c69fb0e80 |
Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Cardiothoracic Centre, Freeman Hospital, Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom |
Raharjo, D.E., Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kunadian, V., Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom, Cardiothoracic Centre, Freeman Hospital, Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom |
[No abstract available] |
coronary artery disease; Editorials; heart disease; morbidity; percutaneous coronary intervention |
adverse event; coronary artery bypass graft; coronary artery disease; diagnostic imaging; human; percutaneous coronary intervention; Coronary Artery Bypass; Coronary Artery Disease; Humans; Percutaneous Coronary Intervention |
Lippincott Williams and Wilkins |
19417640 |
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34340524 |
Review |
Q1 |
2621 |
832 |
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732 |
Wahyudi I., Tendi W., Rahman F., Situmorang G.R., Rodjani A. |
36341995300;57208641745;57194287568;57190001213;6504653529; |
Minimal invasive treatment in pelvic-ureteric junction obstruction: A comprehensive review |
2021 |
Research and Reports in Urology |
13 |
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573 |
580 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113146330&doi=10.2147%2fRRU.S268569&partnerID=40&md5=f261d4ed92d593ac62f22ee1c4284d26 |
Department of Urology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Wahyudi, I., Department of Urology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tendi, W., Department of Urology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahman, F., Department of Urology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Situmorang, G.R., Department of Urology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rodjani, A., Department of Urology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Pelvic-ureteric junction obstruction (PUJO) is a common condition, and one of the lead causes of hydronephrosis in children. Currently, the gold standard treatment of PUJO is open surgery using the Anderson–Hynes-modified dismembered pyeloplasty technique. However, with the advancement of medical technology, several minimal invasive approaches were developed, including endoscopic, laparoscopic, and robotic approach, from which the best choice of surgical technique was yet to be determined. Considering the advantages and disadvantages of these methods, the recommended option is to tailor the best surgical approach to each individual patient, and to the surgeons’ preference and experience. Considering these recent advances, a new algorithm is proposed to choose the best minimal invasive modalities invasive treatment to treat PUJO. © 2021 Wahyudi et al. |
Anderson–Hynes dismembered pyeloplasty; Hydronephrosis; Minimal invasive; PUJO |
child; endoscopic surgery; human; hydronephrosis; laparoscopic surgery; minimally invasive surgery; open surgery; pyeloplasty; Review; robot assisted surgery; surgeon; surgical approach; ureteropelvic junction obstruction |
Dove Medical Press Ltd |
22532447 |
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Review |
Q2 |
506 |
9983 |
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734 |
Pudjiadi A.H. |
18435202300; |
Sepsis-induced T-cell suppression in pediatric sepsis |
2021 |
Critical Care and Shock |
2021 |
July |
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172 |
180 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112603065&partnerID=40&md5=f1958f220fe6de69e13b086f449c61df |
Department of Child Health, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Pudjiadi, A.H., Department of Child Health, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Sepsis contributes to significant mortality and morbidity in children. Despite rigorous resusci-tation effort, adequate antibiotics and advanced medical support, a significant proportion still face mortality due to multiple organ failure. Re-. cent hypothesis suggests host’s immune response pathology in the form of compensatory anti-in-flammatory response syndrome (CARS). This review aims to elucidate the pathophysiology of immune paralysis, both affecting innate and acquired immunity. © 2021, The Indonesian Foundation of Critical Care Medicine. All rights reserved. |
Compensatory anti-inflammatory response syndrome; HLA-DR; Immunoparalysis; Sepsis; TNF-α |
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The Indonesian Foundation of Critical Care Medicine |
14107767 |
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Review |
Q4 |
134 |
24890 |
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739 |
Kamal A.F., Ramang D.S., Prasetyo M. |
56648996700;57195942455;57192905252; |
Thromboembolism in Malignant Musculoskeletal Tumour: A Literature Review |
2021 |
Advances in Orthopedics |
2021 |
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6678167 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111946705&doi=10.1155%2f2021%2f6678167&partnerID=40&md5=d8f7af261692ce3cb5b68127f841fbe3 |
Department of Orthopaedic and Traumatology, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Radiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Kamal, A.F., Department of Orthopaedic and Traumatology, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Ramang, D.S., Department of Orthopaedic and Traumatology, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Prasetyo, M., Department of Radiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Malignant musculoskeletal tumour may cause considerable burden to general health. The fast growth combined with the tumour characteristics and its invasion capability resulted in the poor prognosis of malignant musculoskeletal tumour. Malignant musculoskeletal tumour may cause significant disability by destroying normal tissue that plays important role in body kinematics. Thromboembolism, including deep vein thrombosis, pulmonary embolism, and other kinds of venous thromboembolism, is one of the most underestimated complications of musculoskeletal tumour. Normally, thrombosis ensues when pathologic factors overcame the body hemostatic regulatory capabilities, which will predispose the body to the formation of thrombus. Venous thromboembolism in musculoskeletal tumour may develop as a result of interaction between the tumour pathologic capabilities and its interaction with normal bodily functions. In this study, we reviewed the burden of musculoskeletal tumour and its complication on global health. Then, the review will focus on the pathologic and clinical aspect of thromboembolism in malignant musculoskeletal tumour, including pathophysiology, diagnosis, and treatment based on recent findings and literature. © 2021 Achmad Fauzi Kamal et al. |
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acetylsalicylic acid; antineoplastic agent; low molecular weight heparin; tranexamic acid; blood examination; bone metastasis; cancer chemotherapy; clinical feature; drug cost; dynamic contrast-enhanced magnetic resonance imaging; echography; global health; human; locomotor system cancer; Medline; pathophysiology; patient compliance; Review; ScienceDirect; Scopus; SpringerLink; systematic review; thromboembolism; thrombosis prevention; tumor thrombus; venous thromboembolism |
Hindawi Limited |
20903464 |
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Review |
Q2 |
681 |
7334 |
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761 |
Lesmana C.R.A., Paramitha M.S., Gani R.A. |
8977683000;57212562901;23495930300; |
The Role of Interventional Endoscopic Ultrasound in Liver Diseases: What Have We Learnt? |
2021 |
Canadian Journal of Gastroenterology and Hepatology |
2021 |
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9948979 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110213187&doi=10.1155%2f2021%2f9948979&partnerID=40&md5=a038d06d78df9e699aa4a27ead88d0bb |
Department of Internal Medicine, Hepatobiliary Division, Dr. Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Jakarta, Indonesia; Digestive Disease and GI Oncology Center, Medistra Hospital, Jakarta, Indonesia |
Lesmana, C.R.A., Department of Internal Medicine, Hepatobiliary Division, Dr. Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Jakarta, Indonesia, Digestive Disease and GI Oncology Center, Medistra Hospital, Jakarta, Indonesia; Paramitha, M.S., Department of Internal Medicine, Hepatobiliary Division, Dr. Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Jakarta, Indonesia; Gani, R.A., Department of Internal Medicine, Hepatobiliary Division, Dr. Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Jakarta, Indonesia |
Chronic liver disease (CLD) is still a major problem, where the disease progression will lead to liver cirrhosis (LC) or hepatocellular carcinoma (HCC). Portal hypertension (PH) management and loco-regional therapy for HCC have become the cornerstones in advanced liver disease management. Recently, there are studies looking at the potential role of interventional endoscopic ultrasound (EUS) in liver diseases. EUS may be useful in vascular changes of the digestive wall evaluation, performing dynamic assessment of hemodynamic changes, predicting variceal bleeding and rebleeding risk, and assessing the pharmacological effects. In PH management, EUS-guided vascular therapy - which revolves around glue injection, endovascular coil placement/embolization, and combination of both - has shown promising results. As a diagnostic modality for liver cancer, the implementation of EUS in liver diseases is currently not only limited to liver biopsy (EUS-LB) but also in shear-wave elastography (SWE) and portal pressure gradient measurement, as well as portal vein sampling. The application of EUS-guided radiofrequency ablation (EUS-RFA) and tumor injection can also overcome the limitations shown by both modalities without EUS. Nevertheless, establishing EUS as a firm diagnostic and therapeutic modality is still challenging since the performance of interventional EUS requires high expertise and adequate facilities. © 2021 Cosmas Rinaldi A. Lesmana et al. |
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azygos vein; brachytherapy; chronic liver disease; contrast-enhanced ultrasound; cryotherapy; Doppler flowmetry; elastography; endoscopic ultrasonography; gastrointestinal hemorrhage; human; liver abscess; liver biopsy; liver cirrhosis; liver injury; liver metastasis; nonhuman; paracentesis; peritonitis; portal vein blood pressure; predictive value; radiation exposure; regional perfusion; Review; risk assessment; sclerotherapy; sensitivity and specificity; shear wave elastography; splanchnic blood flow; diagnostic imaging; endoscopic ultrasonography; esophagus varices; interventional ultrasonography; liver cell carcinoma; liver tumor; tumor recurrence; Carcinoma, Hepatocellular; Endosonography; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Humans; Liver Neoplasms; Neoplasm R |
Hindawi Limited |
22912789 |
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34258255 |
Review |
Q2 |
921 |
4950 |
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781 |
Hidayat M., Handayani D., Nurwidya F., Andarini S.L. |
56435992700;57219413838;55221773800;8716259500; |
Hyperinflammation syndrome in covid-19 disease: Pathogenesis and potential immunomodulatory agents [Covid-19 hastalığında hiperenflamasyon sendromu: Patogenez ve potansiyel immünomodülatuvar ajanlar] |
2021 |
Turkish Journal of Immunology |
9 |
1 |
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1 |
11 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108585451&doi=10.5222%2fTJI.2021.92486&partnerID=40&md5=e11fbb69c1d65d6dcdb052da54e5cf96 |
Faculty of Medicine, University of Mataram, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia-Persahabatan Hospital, Jakarta, Indonesia |
Hidayat, M., Faculty of Medicine, University of Mataram, Indonesia; Handayani, D., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia-Persahabatan Hospital, Jakarta, Indonesia; Nurwidya, F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia-Persahabatan Hospital, Jakarta, Indonesia; Andarini, S.L., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia-Persahabatan Hospital, Jakarta, Indonesia |
The coronavirus disease 2019 (COVID-19) pandemic caused by infection of the SARS-CoV-2 virus has affected millions of people in the world. The pathogenesis and clinical manifestations of COVID-19 disease are tightly influenced by the host immune response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. In some condition, the immune response might be uncontrolled, giving rise to hyperinflammatory conditions marked by excessive release of proinflammatory cytokines (cytokine storms) in severe COVID-19 patients, which then can cause acute respiratory distress syndrome (ARDS), multiorgan failure, and death. Furthermore, treatment using immunomodulator agents including immunostimulatory and immunosuppressive agents can be an option in achieving successful treatment. In this review, we discuss the pathogenesis of the disease, including host immune responses to SARS-CoV-2 virus infection, and immune mechanisms which contribute to the disease severity and death as well as several potential immunomodulatory agents which can be used in the management of hyperinflammatory syndrome of severe COVID-19. © Turkish Journal of Immunlogy. |
Coronavirus disease 2019 (COVID-19); Cytokine storm; Hyperinflammation syndrome; Immunomodulatory treatment |
chloroquine; convalescent plasma; hydroxychloroquine; immunoglobulin; immunomodulating agent; interferon; interleukin 1 receptor blocking agent; interleukin 6 antibody; neutralizing antibody; sarilumab; tocilizumab; tumor necrosis factor inhibitor; adult respiratory distress syndrome; antibody dependent enhancement; coronavirus disease 2019; cytokine production; cytokine release; cytokine storm; disease severity; human; hyperinflammatory syndrome; immune response; immune system; immunosuppressive treatment; mortality; multiple organ failure; pandemic; Review; Severe acute respiratory syndrome coronavirus 2; signal transduction; stem cell transplantation; virus cell interaction; virus pathogenesis; virus replication |
Turkish Society of Immunology |
1301109X |
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Review |
Q4 |
115 |
27813 |
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794 |
Subali A.D., Wiyono L. |
57222071247;57207889054; |
Reverse Transcriptase Loop Mediated Isothermal Amplification (RT-LAMP) for COVID-19 diagnosis: a systematic review and meta-analysis |
2021 |
Pathogens and Global Health |
115 |
5 |
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281 |
291 |
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5 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107466709&doi=10.1080%2f20477724.2021.1933335&partnerID=40&md5=bc2cfc39928d141c8b322792377bdf60 |
Faculty of Medicine, Universitas Brawijaya, Malang, East Java, Indonesia; Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Subali, A.D., Faculty of Medicine, Universitas Brawijaya, Malang, East Java, Indonesia, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wiyono, L., Faculty of Medicine, Universitas Brawijaya, Malang, East Java, Indonesia, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
COVID-19 pandemic has become a global public health priority. The rapid increase in infection numbers, along with a significant number of deaths, has made the virus a serious threat to human health. Rapid, reliable, and simple diagnostic methods are critical to controlling the disease. While Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) is the current diagnostic gold standard, Reverse Transcriptase Loop-Mediated Isothermal Amplification (RT-LAMP) appears to be a compelling alternative diagnostic test due to its greater simplicity, shorter time to obtain a result, and lower cost. This study examined RT-LAMP application for rapid identification of SARS-CoV-2 infection compared to the RT-PCR assay. A systematic review and meta-analysis was conducted over six scientific databases in accordance with PRISMA guidelines. Original studies published in English conducted on human clinical samples were included. Articles evaluating the sensitivity and specificity of RT-LAMP relative to RT-PCR were considered eligible. Quality assessment of bias and applicability was examined based on QUADAS-2. A total of 351 studies were found based on the keywords and search queries. Fourteen eligible case–control studies fit the mentioned criteria. Quality assessment using QUADAS-2 indicated alow risk of bias for all included studies. All case studies, containing 2,112 samples, had acumulative sensitivity of 95.5% (CI 97.5% = 90.8–97.9%) and cumulative specificity of 99.5% (CI 97.5% = 97.7–99.9%). The RT-LAMP assay could be areliable alternative COVID-19 diagnostic method due to its reduced cost and processing time compared to RT-PCR. RT-LAMP could potentially be utilized during critical high-throughput and high-demand situations. © 2021 Informa UK Limited, trading as Taylor & Francis Group. |
COVID-19; diagnostic test; RT-LAMP; RT-PCR; SARS-CoV-2 |
coronavirus RNA dependent RNA polymerase; coronavirus spike glycoprotein; envelope protein; nonstructural protein 3; nucleocapsid protein; RNA directed DNA polymerase; virus RNA; coronavirus disease 2019; diagnostic test accuracy study; human; limit of detection; meta analysis; nasopharyngeal swab; open reading frame; practice guideline; receiver operating characteristic; reverse transcription loop mediated isothermal amplification; reverse transcription polymerase chain reaction; Review; sensitivity and specificity; Severe acute respiratory syndrome coronavirus 2; systematic review; virus gene; genetics; molecular diagnosis; nucleic acid amplification; pandemic; COVID-19; Humans; Molecular Diagnostic Techniques; Nucleic Acid Amplification Techniques; Pandemics; Reverse Transcriptase Polym |
Taylor and Francis Ltd. |
20477724 |
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34086539 |
Review |
Q1 |
945 |
4761 |
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796 |
Pontoh L.A.P., Ismail H.D., Fiolin J., Yausep O.E. |
57192907426;57224810749;57194498274;57200086151; |
Pain following single-bundle versus double-bundle anterior cruciate ligament reconstruction: A systematic review |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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153 |
162 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107326267&doi=10.3889%2foamjms.2021.5995&partnerID=40&md5=907e110a1eb993238ca4374c25cdcb6a |
Department of Orthopaedic and Traumatology, Faculty of Medicine, Universitas Indonesia, Fatmawati General Hospital, Jakarta, Indonesia; Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Jakarta Knee Orthopaedic Sports Center, Pondok Indah Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Pontoh, L.A.P., Department of Orthopaedic and Traumatology, Faculty of Medicine, Universitas Indonesia, Fatmawati General Hospital, Jakarta, Indonesia; Ismail, H.D., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Fiolin, J., Jakarta Knee Orthopaedic Sports Center, Pondok Indah Hospital, Jakarta, Indonesia; Yausep, O.E., Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
BACKGROUND: Double-bundle (DB) anterior cruciate ligament reconstruction (ACLR) has been known to result in better functional outcomes, joint stability, and lower revision rates compared to single-bundle (SB) ACLR. However, given the increased invasiveness and damage to the surrounding tissue area, it is proposed that it may be associated with increased pain. AIM: This review aims to gather all studies and literature that reported pain as an outcome when comparing SB versus DB ACLR. METHODS: Literature searching was conducted across seven search engines for studies reporting pain as an outcome and comparing SB versus DB ACLR. RESULTS: Eight studies met the eligibility criteria and were included in the study. Overall, the studies show variable findings regarding pain in DB compared to SB ACLR, with the only statistically significant results from two studies indicating that DB ACLR is associated with more pain than SB ACLR. CONCLUSION: Based on the limited evidence available, no conclusions can be made regarding the pain experienced between people receiving either procedure. This constitutes a need for additional studies with increased follow-up time periods, larger sample size, and better study design. © 2021 Ludwig A. P. Pontoh, H. D. Ismail, Jessica Fiolin, Oliver Emmanuel Yausep. |
Anterior cruciate ligament; Double bundle; Pain; Reconstruction; Single bundle |
analgesic agent; anesthetic agent; anesthesia; anterior cruciate ligament injury; anterior cruciate ligament reconstruction; collateral ligament; data analysis; data extraction; follow up; gracilis flap; hamstring muscle; hamstring tendon; human; joint stability; knee ligament; knee meniscus rupture; knee pain; ligament surgery; meta analysis; operation duration; pain; randomized controlled trial (topic); Review; systematic review; tendon graft; visual analog scale |
Scientific Foundation SPIROSKI |
18579655 |
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Review |
Q3 |
288 |
15252 |
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811 |
Dinarti L.K., Anggrahini D.W., Lilyasari O., Siswanto B.B., Hartopo A.B. |
57192908812;35285645700;57192914838;14422648800;36056281100; |
Pulmonary arterial hypertension in Indonesia: Current status and local application of international guidelines |
2021 |
Global Heart |
16 |
1 |
23 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105601627&doi=10.5334%2fGH.944&partnerID=40&md5=a344de6f2ae7c858408e0bbec6a2f09e |
Department of Cardiology and Vascular Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Dr. Sardjito Hospital, Yogyakarta, Indonesia; Department Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
Dinarti, L.K., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Dr. Sardjito Hospital, Yogyakarta, Indonesia; Anggrahini, D.W., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Dr. Sardjito Hospital, Yogyakarta, Indonesia; Lilyasari, O., Department Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Siswanto, B.B., Department Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Hartopo, A.B., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Dr. Sardjito Hospital, Yogyakarta, Indonesia |
Recent advances in the diagnosis and management of pulmonary arterial hypertension (PAH) have led to a significant improvement in the outcomes for patients with PAH. However, prompt and accurate diagnosis of PAH remains an unmet challenge due to lack of awareness and lack of meticulous data to profile the etiology and pathophysiology of this rare progressive disease, especially in low- and middle-income country. In Indonesia, the true prevalence and incidence of different subtypes of PAH in general population is still unknown. The Congenital HeARt Disease in adult and Pulmonary Hypertension (COHARD-PH) registry was the first single-center prospective registry in Indonesia, which indicated that almost 80% of adult patients with congenital heart disease (CHD) had experienced PAH and even Eisenmenger syndrome due to delayed diagnosis. Screening for early detection of asymptomatic CHD in children is yet to be systematically established in Indonesia, leading to undiagnosed and uncorrected CHD in adulthood. There are no specific national guidelines focusing on diagnostic workup and treatment of PAH in Indonesia. Furthermore, the lack of adequate diagnostic facilities, limited treatment availability, and limited drug coverage under the National Health Insurance Scheme are key issues that remain unaddressed. This review focuses on the diagnosis, treatment, and management of PAH associated with CHD in Indonesia as per international guidelines. We have proposed recommendations to effectively control and prevent PAH associated with CHD in Indonesia. The paper should be of interest to readers in the area of medical management and policy makers especially in low- and middle-income countries. © 2021 The Author(s). |
Congenital heart disease (CHD); Etiology; Indonesia; International guideline; Lower middle-income region; Pulmonary arterial hypertension (PAH) |
antihypertensive agent; vasodilator agent; clinical research; congenital heart disease; early diagnosis; health care policy; human; Indonesia; maternal mortality; practice guideline; priority journal; prognostic assessment; pulmonary hypertension; Review; risk assessment; adult; congenital heart malformation; Eisenmenger complex; female; pregnancy; pulmonary hypertension; Adult; Eisenmenger Complex; Female; Heart Defects, Congenital; Humans; Hypertension, Pulmonary; Indonesia; Pregnancy; Pulmonary Arterial Hypertension |
Web Portal Ubiquity Press |
22118160 |
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34040936 |
Review |
Q1 |
1012 |
4314 |
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815 |
Permata T.B.M., Sekarutami S.M., Nuryadi E., Giselvania A., Gondhowiardjo S. |
57197808751;56576294500;57197806814;57217201891;6508327402; |
Rapid advancement in cancer genomic big data in the pursuit of precision oncology |
2021 |
Medical Journal of Indonesia |
30 |
1 |
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81 |
85 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105003444&doi=10.13181%2fmji.rev.204250&partnerID=40&md5=ac20a978c8162343bd2dd077ffd5908e |
Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Permata, T.B.M., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sekarutami, S.M., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Nuryadi, E., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Giselvania, A., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Gondhowiardjo, S., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
In the current big data era, massive genomic cancer data are available for open access from anywhere in the world. They are obtained from popular platforms, such as The Cancer Genome Atlas, which provides genetic information from clinical samples, and Cancer Cell Line Encyclopedia, which offers genomic data of cancer cell lines. For convenient analysis, user-friendly tools, such as the Tumor Immune Estimation Resource (TIMER), which can be used to analyze tumor-infiltrating immune cells comprehensively, are also emerging. In clinical practice, clinical sequencing has been recommended for patients with cancer in many countries. Despite its many challenges, it enables the application of precision medicine, especially in medical oncology. In this review, several efforts devoted to accomplishing precision oncology and applying big data for use in Indonesia are discussed. Utilizing open access genomic data in writing research articles is also described. © 2021 Authors. |
Cancer genetic database; Oncology; Personalized medicine |
adult; big data; cancer cell line; clinical practice; controlled study; genetic database; human; human cell; immunocompetent cell; Indonesia; personalized medicine; review; writing |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Review |
Q4 |
164 |
21905 |
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