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753 |
Ocktariyana, Hikmawati N., Hestiantoro A., Muharam R., Marwali M.L., Surur A., Aninditha T., Pratama G., Zahrah A., Naura N.F., Asmarinah |
57210235127;55901590700;8743255100;57191492732;57204106005;57226169369;57189611205;57195959221;57205418186;57226137609;15820317600; |
Analysis of dna methylation level and mrna expression of transient receptor ankyrin member 1 (Trpa1) in endometriosis-associated pain |
2021 |
Asia-Pacific Journal of Molecular Biology and Biotechnology |
29 |
3 |
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1 |
10 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110656378&partnerID=40&md5=011cfc4031284fa4520681b99cc9b930 |
Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Human Reproductive, Infertility, and Family Planning Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Endometriosis Center, Fatmawati Hospital, Jakarta, Indonesia; Neurology Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Undergraduate Program in Biological Sciences, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Jakarta, Indonesia; Medical Biology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Midwifery, Politeknik Kesehatan Palembang, Ministry of Health, Palembang, Indonesia |
Ocktariyana, Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Midwifery, Politeknik Kesehatan Palembang, Ministry of Health, Palembang, Indonesia; Hikmawati, N., Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hestiantoro, A., Human Reproductive, Infertility, and Family Planning Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Muharam, R., Human Reproductive, Infertility, and Family Planning Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Marwali, M.L., Endometriosis Center, Fatmawati Hospital, Jakarta, Indonesia; Surur, A., Endometriosis Center, Fatmawati Hospital, Jakarta, Indonesia; Aninditha, T., Neurology Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Pratama, G., Human Reproductive, Infertility, and Family Planning Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Zahrah, A., Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Naura, N.F., Undergraduate Program in Biological Sciences, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Jakarta, Indonesia; Asmarinah, Human Reproductive, Infertility, and Family Planning Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Medical Biology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Transient Receptor Ankyrin Member 1 (TRPA1) is an ion channel family protein that regulates pain sensation through sensory neurons' activity. This study's purpose to analyzes the DNA methylation and mRNA expression level of the TRPA1 gene in endometriosis and its correlation with pain level. Twenty samples of peritoneal endometriosis and endometrial samples were obtained from women with endometriosis, which was subsequently compared to 20 endometrial samples of women without endometriosis. The DNA methylation level of TRPA1 was analyzed using Methylation-specific PCR (MS-PCR) and ImageJ software, while the mRNA expression of TRPA1 was analyzed using qRT-PCR. Furthermore, the pain level was measured using the numeric rating scale (NRS) by interviewing all the women. This study showed that there was a significant difference in the mRNA expression of TRPA1 in peritoneal endometriosis. The TRPA1 was unmethylated in both peritoneal and endometrial samples in endometriosis. However, DNA Methylation level of TRPA1 in peritoneal and endometrial of endometriosis compared to normal endometrial were no significant difference. Additionally, there was no correlation between DNA methylation level and mRNA expression level of TRPA1 in all samples, along with the endometriosis-associated pain. © 2021, University of Malaya. All rights reserved. |
DNA methylation; Endometriosis; MRNA expression; Pain; TRPA1 |
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University of Malaya |
01287451 |
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Article |
Q4 |
137 |
24544 |
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764 |
Yulia D.E., Kurnia K.H., Mahyuddin M., Edwar L., Amanda L. |
57225947931;57222405280;57225946039;55695047800;57225929959; |
Successful Management of a Rare Paediatric Orbital Subperiosteal Abscess: A Case Report |
2021 |
African Vision and Eye Health |
80 |
1 |
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1 |
3 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109939244&doi=10.4102%2fAVEH.V80I1.631&partnerID=40&md5=ad4fc29a3f5162b1ce2a0a28e7eafe79 |
Department of Ophthalmology, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Yulia, D.E., Department of Ophthalmology, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Kurnia, K.H., Department of Ophthalmology, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Mahyuddin, M., Department of Ophthalmology, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Edwar, L., Department of Ophthalmology, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Amanda, L., Department of Ophthalmology, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Paediatric orbital subperiosteal abscess (SPA) requires prompt and appropriate treatment to prevent further complication. A 10-year-old girl with a history of sinusitis came with progressive swelling on her left eye, non-axial proptosis and visual acuity (VA) was 2/60. A computed tomography scan revealed a SPA formation in the superior left orbit. This report highlights that intravenous antibiotic with incision and drainage surgery improved the VA with resolution of proptosis and swelling. © 2021. The Author(s). Licensee: AOSIS. This work is licensed under the Creative Commons Attribution License. |
antibiotic administration; incision and drainage; non-axial proptosis; orbital infection; paediatric subperiosteal abscess |
amoxicillin; antibiotic agent; ceftriaxone; methylprednisolone; metronidazole; Article; case report; child; clinical article; computer assisted tomography; endoscopic sinus surgery; exophthalmos; eye pain; eye swelling; female; follow up; human; intraocular pressure; orbit infection; orbital subperiosteal abscess; visual acuity |
AOSIS (pty) Ltd |
24133183 |
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Article |
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186 |
20274 |
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776 |
Liem I.K., Oktavina R., Zakiyah, Anggraini D., Deraya I.E., Kodariah R., Krisnuhoni E., Wuyung P.E. |
55802927800;57224993301;57224999441;57225000673;57216313121;14010667100;35310982200;57192889605; |
Intravenous injection of umbilical cord-derived mesenchymal stem cells improved regeneration of rat liver after 2aaf/ccl4-induced injury |
2021 |
OnLine Journal of Biological Sciences |
21 |
2 |
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317 |
326 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108885347&doi=10.3844%2fojbsci.2021.317.326&partnerID=40&md5=e4defc3d20063b1647d2241805bc3694 |
Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell and Tissue Engineering Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine and Health Science, Universitas Kristen Krida Wacana, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine, Universitas Yarsi, Jakarta, Indonesia; Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Animal Research Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Liem, I.K., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell and Tissue Engineering Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Oktavina, R., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine and Health Science, Universitas Kristen Krida Wacana, Jakarta, Indonesia; Zakiyah, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine, Universitas Yarsi, Jakarta, Indonesia; Anggraini, D., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell and Tissue Engineering Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Deraya, I.E., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kodariah, R., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Krisnuhoni, E., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wuyung, P.E., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Animal Research Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
The effectivity of Mesenchymal Stem Cell (MSC) therapy for chronic liver injury is still questioned due to its possibility to have a pro-fibrotic effects. Other consideration is the preferably peripheral Intravenous (IV) route of application rather than direct to the target organ, such as portal vein or splenic vein, since the most of MSC will be trapped in the lung and other organs. Therefore, a study has been carried out in an animal model of chronic liver injury, 2AAF/CCl4 rats, to find out whether IV injection of single dose, 1×106 human umbilical cord-derived MSC (hUC-MSC) can regenerate the liver tissue and reduce the fibrosis. Male Wistar rats (n = 18, 8 weeks, 160-200 g) were divided into three groups of six rats, i.e., group I (control/healthy rats), group II (2AAF/CCl4-induced liver injury with hUC-MSC injected rats) and group III (2AAF/CCl4-incuded liver injury without hUC-MSC injected rats). Gross anatomical features of the livers and blood examination were tested. There was no significant different of the Alanine Aminotransferase (ALT) and Albumin serum level between groups; however there was a tendency of ALT decrease and Albumin increase in stem cells treated rats (group II). Histopathological observation using hematoxylin eosin and Masson’s trichrome staining showed an improvement in the liver damage condition (reduction of necrosis and coverage area of fat degeneration) and an improvement in the fibrosis condition in the group II compared to the group III. None of group II rat had fallen into cirrhosis as seen in group III. Immunohistochemistry staining against Caspase 3 (biomarker for apoptosis) also showed significant reduction (p = 0.038; Tukey multiple comparison test) of group II expression index (2.74%) compared to the group III (8.64%). In conclusion, IV injection of single dose, 1×106 hUC-MSC could regenerate the liver tissue and reduce the fibrosis in 2AAF/CCl4 rats model of chronic liver injury. © 2021 Isabella Kurnia Liem, Reni Oktavina, Zakiyah, Dian Anggraini, Irwina Eka Deraya, Ria Kodariah, Ening Krisnuhoni, and Puspita Eka Wuyung. |
2AAF/CCl4; Caspase 3; Liver Fibrosis; Liver Injury; Liver Regeneration; MSC |
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Science Publications |
16084217 |
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Article |
Q4 |
152 |
23000 |
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779 |
Kartika R.W., Alwi I., Suyatna F.D., Yunir E., Waspadji S., Immanuel S., Silalahi T., Sungkar S., Rachmat J., Bardosono S., Reksodiputro M.H. |
57223447932;15055173800;56039633100;36520254800;8678136400;12777341300;56275255400;57016857300;6507225348;21933841000;35090488800; |
Advance-Platelet Rich Fibrin and Hyaluronic Acid Combination Improves Interleukin-6 and Granulation Index in Diabetic Foot Ulcer Patients |
2021 |
Indonesian Biomedical Journal |
13 |
2 |
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170 |
177 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108646812&doi=10.18585%2finabj.v13i2.1501&partnerID=40&md5=38a4d6d4cd5994b04badcabc1939a76e |
Doctoral Program in Medical Science, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Department of Thoracic, Cardiac and Vascular Surgery, Krida Wacana Christian University, Jl. Arjuna Utara No.6, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia; Department of Clinical Pharmacology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia; Department of Internal Medicine, Krida Wacana Christian University, Jl. Arjuna Utara No.6, Jakarta, Indonesia; Department of Clinical Parasitology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Department of Thoracic Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Facial Plastic Reconstructive Division, Department of Otorhinolaryngology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia |
Kartika, R.W., Doctoral Program in Medical Science, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia, Department of Thoracic, Cardiac and Vascular Surgery, Krida Wacana Christian University, Jl. Arjuna Utara No.6, Jakarta, Indonesia; Alwi, I., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia; Suyatna, F.D., Department of Clinical Pharmacology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Yunir, E., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia; Waspadji, S., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia; Immanuel, S., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia; Silalahi, T., Department of Internal Medicine, Krida Wacana Christian University, Jl. Arjuna Utara No.6, Jakarta, Indonesia; Sungkar, S., Department of Clinical Parasitology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Rachmat, J., Department of Thoracic Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Reksodiputro, M.H., Facial Plastic Reconstructive Division, Department of Otorhinolaryngology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia |
BACKGROUND: Diabetic foot ulcer (DFU) is the most common and threatening complication of Diabetes Mellitus (DM). Ideal wound dressing for DFU management should relieve symptoms, provide wound protection, and encourage healing. Advanced-Platelet Rich Fibrin (A-PRF) and Hyaluronic Acid (HA) have been proven to improve wound healing process. This study was aimed to demonstrate the ability of combination of A-PRF and HA in reducing inflammation and improving DFU tissue healing. METHODS: Twenty DFU subjects were involved in this study, and divided into two groups based on the topical fibrin gel treatment: A-PRF + HA group and A-PRF only group. A-PRF was obtained by peripheral blood centrifugation. A-PRF + HA was prepared by homogening A-PRF and AH with a ratio of 1:0.6. Interleukin-6 (IL-6) level, granulation index (GI), numeric pain score (NPS), and inflammation clinical symptoms (ICS) were assessed on day-0, 3, 7 and 14. RESULTS: Wound swabs' IL-6 level on day-7 was found to be significantly lower in A-PRF + HA compared to A-PRF alone (p=0.041). The IL-6 level reduction also found to be significant higher either in wound swabs (day 0-7, p=0.015) or fibrin gel (day 0-3, p=0.049; day 0-7, p=0.034). A-PRF + HA treatment significantly increased the GI even since day-3 (p=0.043), with lower NPS (p<0.001), and ICS score. CONCLUSION: The combination of A-PRF and HA increases the GI in DFU healing by reducing the inflammation state which will induce the angiogenesis process, as well as reducing pain in DFU subjects better than A-PRF alone. © 2021. All Rights Reserved. |
angiogenesis; inflammation; interleukin-6; proliferation; wound healing |
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Prodia Education and Research Institute |
20853297 |
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Article |
Q4 |
160 |
22228 |
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780 |
Giantini A., Timan I.S., Listiyaningsih E., Dharma R., Setiabudy R., Alwi I., Partakusuma L.G., Indrasari N.D., Harahap· A.R., Suparmin· S., Sahar W., Sukmawan R. |
12776781400;6602793366;57224237184;12777817700;6602316235;15055173800;57224924047;6506289872;57224930255;57218100688;57224929934;8651025300; |
Comparison of Light Transmission Aggregometry and VerifyNow in Detecting Clopidogrel Resistance and Factors Affecting Clopidogrel Resistance in AMI-EST Patients Undergoing Percutaneous Coronary Intervention: A Cross-Sectional Study |
2021 |
Indonesian Biomedical Journal |
13 |
2 |
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163 |
169 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108601516&doi=10.18585%2finabj.v13i2.1477&partnerID=40&md5=2ade19315f56303e4e2ab7f2428ec652 |
Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Department of Clinical Pathology, Cipto Mangunkusumo National Central General Hospital, Jl. Pangeran Diponegoro No.71, Jakarta, Indonesia; Harapan Kita Heart and Vascular Hospital, Jl. Letjen S. Parman Kav.87, Jakarta, Indonesia; Department of Internal Medicine, Cardiology Division, Metropolitan Medical Centre (MMC) Hospital, Jl. H.R. Rasuna Said Kav. C-21, Jakarta, Indonesia; Eijkman Institute, Jl. Pangeran Diponegoro No. 69, Jakarta, Indonesia |
Giantini, A., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia, Department of Clinical Pathology, Cipto Mangunkusumo National Central General Hospital, Jl. Pangeran Diponegoro No.71, Jakarta, Indonesia; Timan, I.S., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia, Department of Clinical Pathology, Cipto Mangunkusumo National Central General Hospital, Jl. Pangeran Diponegoro No.71, Jakarta, Indonesia; Listiyaningsih, E., Harapan Kita Heart and Vascular Hospital, Jl. Letjen S. Parman Kav.87, Jakarta, Indonesia; Dharma, R., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia, Department of Clinical Pathology, Cipto Mangunkusumo National Central General Hospital, Jl. Pangeran Diponegoro No.71, Jakarta, Indonesia; Setiabudy, R., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Alwi, I., Department of Internal Medicine, Cardiology Division, Metropolitan Medical Centre (MMC) Hospital, Jl. H.R. Rasuna Said Kav. C-21, Jakarta, Indonesia; Partakusuma, L.G., Harapan Kita Heart and Vascular Hospital, Jl. Letjen S. Parman Kav.87, Jakarta, Indonesia; Indrasari, N.D., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia, Department of Clinical Pathology, Cipto Mangunkusumo National Central General Hospital, Jl. Pangeran Diponegoro No.71, Jakarta, Indonesia; Harahap·, A.R., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia, Eijkman Institute, Jl. Pangeran Diponegoro No. 69, Jakarta, Indonesia; Suparmin·, S., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Sahar, W., Harapan Kita Heart and Vascular Hospital, Jl. Letjen S. Parman Kav.87, Jakarta, Indonesia; Sukmawan, R., Harapan Kita Heart and Vascular Hospital, Jl. Letjen S. Parman Kav.87, Jakarta, Indonesia |
BACKGROUND: Light transmission aggregometry (LTA) and VerifyNow is commonly used to measure platelet responsiveness to clopidogrel. This study aimed to compare the results of LTA and VerifyNow P2Y12 assay for assessing the clopidogrel resistance in patients undergoing percutaneous coronary intervention and determine factors affecting clopidogrel resistance. METHODS: The subjects were 119 patients who underwent percutaneous coronary intervention (PCI) and had given loading dose of 600 mg clopidogrel. Blood samples were taken at 6 hour after clopidogrel loading dose. Platelet aggregation was measured by LTA and Verify Now. RESULTS: LTA and VerifyNow assay showed fair agreement with Kappa=0.270, p=0.001. The proportion of resistance to clopidogrel using VerifyNow was 21.8% and LTA was 47.1%. Patients with diabetes melitus were more likely to develop clopidogrel resistance than patients without diabetes (OR of 7.67; 95% CI: 1.87-31.50; p=0.005). CONCLUSION: The ability of LTA and VerifyNow in detecting clopidogrel resistance were not comparable. Multivariate analysis results for VerifyNow shows diabetes mellitus as the greatest predictors of clopidogrel resistance. © 2021. All Rights Reserved. |
agreement; clopidogrel resistance; LTA; predictor; VerifyNow |
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Prodia Education and Research Institute |
20853297 |
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Article |
Q4 |
160 |
22228 |
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781 |
Hidayat M., Handayani D., Nurwidya F., Andarini S.L. |
56435992700;57219413838;55221773800;8716259500; |
Hyperinflammation syndrome in covid-19 disease: Pathogenesis and potential immunomodulatory agents [Covid-19 hastalığında hiperenflamasyon sendromu: Patogenez ve potansiyel immünomodülatuvar ajanlar] |
2021 |
Turkish Journal of Immunology |
9 |
1 |
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1 |
11 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108585451&doi=10.5222%2fTJI.2021.92486&partnerID=40&md5=e11fbb69c1d65d6dcdb052da54e5cf96 |
Faculty of Medicine, University of Mataram, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia-Persahabatan Hospital, Jakarta, Indonesia |
Hidayat, M., Faculty of Medicine, University of Mataram, Indonesia; Handayani, D., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia-Persahabatan Hospital, Jakarta, Indonesia; Nurwidya, F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia-Persahabatan Hospital, Jakarta, Indonesia; Andarini, S.L., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia-Persahabatan Hospital, Jakarta, Indonesia |
The coronavirus disease 2019 (COVID-19) pandemic caused by infection of the SARS-CoV-2 virus has affected millions of people in the world. The pathogenesis and clinical manifestations of COVID-19 disease are tightly influenced by the host immune response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. In some condition, the immune response might be uncontrolled, giving rise to hyperinflammatory conditions marked by excessive release of proinflammatory cytokines (cytokine storms) in severe COVID-19 patients, which then can cause acute respiratory distress syndrome (ARDS), multiorgan failure, and death. Furthermore, treatment using immunomodulator agents including immunostimulatory and immunosuppressive agents can be an option in achieving successful treatment. In this review, we discuss the pathogenesis of the disease, including host immune responses to SARS-CoV-2 virus infection, and immune mechanisms which contribute to the disease severity and death as well as several potential immunomodulatory agents which can be used in the management of hyperinflammatory syndrome of severe COVID-19. © Turkish Journal of Immunlogy. |
Coronavirus disease 2019 (COVID-19); Cytokine storm; Hyperinflammation syndrome; Immunomodulatory treatment |
chloroquine; convalescent plasma; hydroxychloroquine; immunoglobulin; immunomodulating agent; interferon; interleukin 1 receptor blocking agent; interleukin 6 antibody; neutralizing antibody; sarilumab; tocilizumab; tumor necrosis factor inhibitor; adult respiratory distress syndrome; antibody dependent enhancement; coronavirus disease 2019; cytokine production; cytokine release; cytokine storm; disease severity; human; hyperinflammatory syndrome; immune response; immune system; immunosuppressive treatment; mortality; multiple organ failure; pandemic; Review; Severe acute respiratory syndrome coronavirus 2; signal transduction; stem cell transplantation; virus cell interaction; virus pathogenesis; virus replication |
Turkish Society of Immunology |
1301109X |
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Review |
Q4 |
115 |
27813 |
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784 |
Bustamam A., Sarwinda D., Paradisa R.H., Victor A.A., Yudantha A.R., Siswantining T. |
36815737800;56119401500;57221562575;57191055282;55489644900;57193446800; |
Evaluation of convolutional neural network variants for diagnosis of diabetic retinopathy |
2021 |
Communications in Mathematical Biology and Neuroscience |
2021 |
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42 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108354325&doi=10.28919%2fcmbn%2f5660&partnerID=40&md5=46f614ba3ad44a65354d6ec3e2b41ab1 |
Department of Mathematics, Faculty of Mathematics and Natural Science, Universitas Indonesia, Depok, Indonesia; Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Bustamam, A., Department of Mathematics, Faculty of Mathematics and Natural Science, Universitas Indonesia, Depok, Indonesia; Sarwinda, D., Department of Mathematics, Faculty of Mathematics and Natural Science, Universitas Indonesia, Depok, Indonesia; Paradisa, R.H., Department of Mathematics, Faculty of Mathematics and Natural Science, Universitas Indonesia, Depok, Indonesia; Victor, A.A., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Yudantha, A.R., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Siswantining, T., Department of Mathematics, Faculty of Mathematics and Natural Science, Universitas Indonesia, Depok, Indonesia |
Diabetic Retinopathy (DR) is a long-term complication of Diabetes Mellitus (DM) that impairs vision. This stage occurs in visual impairment and blindness if treated late. DR identified through scanning fundus images. A technique on classifying DR in fundus images is the deep learning approach, one of the methods of implementing machine learning. In this study, the Convolutional Neural Networks (CNN) method applied with the ResNet-50 and DenseNet-121 architectures. The data adopted in this analysis was generated from DIARETDB1, an online database containing fundus images. Then, the pre-processing stage is carried out on the fundus image to improve model performance, such as selected the green channel from the images and inverted it, converted the images into grayscale images, and applied Contrast Limited Adaptive Histogram Equalization (CLAHE) for uniform contrast in the images. The outcome of this research indicates that the ResNet-50 model is better than DenseNet-121 in detecting DR. The most reliable results from the ResNet-50 model's case testing are accuracy, precision, and recall of 95%, 98%, and 96% respectively. © 2021, SCIK Publishing Corporation. All rights reserved. |
Deep learning; Densenet; Diabetic retinopathy; Fundus image; Resnet |
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SCIK Publishing Corporation |
20522541 |
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Article |
Q4 |
189 |
20081 |
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786 |
Sahar N., Birowo P., Thuffi R., Muharram A.R., Ode Z.W., Subahar R., Yazid F., Handayani S.I., Prasasty V.D. |
57212464367;6504153311;57212475033;57224640920;57222324817;57224626083;57207890516;57207819540;56019989700; |
Fsh receptor and ki-67 protein expressions of endometrial macaque in mid-luteal phase after exposure to various doses of recombinant fsh and fixed-dose of gnrh agonist |
2021 |
OnLine Journal of Biological Sciences |
21 |
2 |
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260 |
266 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108083891&doi=10.3844%2fojbsci.2021.260.266&partnerID=40&md5=6752f9329d0eda8fbfaee279007348a8 |
Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Departement of Urology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Departemen of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia |
Sahar, N., Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Birowo, P., Departement of Urology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Thuffi, R., Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Muharram, A.R., Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ode, Z.W., Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Subahar, R., Departemen of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yazid, F., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Handayani, S.I., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Prasasty, V.D., Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia |
There are many advances in Assisted Reproductive Technologies (ARTs). However, implantation rates are still low. The embryo implantation is a mutual interaction between the blastocyst and endometrium. This study aimed to investigate the endometrial cell proliferation stimulated by recombinant Follicle-Stimulating Hormone (rFSH) in various doses by looking at FSH-Receptor (FSHR) and Ki-67 protein expressions. The studied samples were Stored Biological Materials (SBMs) from the endometrial tissue of Macaca nemestrina. All sample was obtained from fifteen macaques, divided into four groups, which three groups were treated with rFSH and given fixed-dose (160 µg/day) of Gonadotropin-Releasing Hormone (GnRH) agonists and one control group as normal group. The three treated macaque groups were stimulated with 30, 50 and 70 IU doses of rFSH. There was no significant difference in various doses of rFSH towards FSHR and Ki-67 expressions in endometrial tissue of M. nemestrina. Therefore, this result did not significantly correlate FSHR and Ki-67 expressions in the endometrial tissue of M. nemestrina after rFSH administration. Moreover, the highest rFSH dose did not reduce the FSHR and Ki-67 expressions and there was no correlation between FSHR and Ki-67 expressions. It can be concluded that macaque endometrial cells were receptive to the given dosages of rFSH. © 2021 Nurhuda Sahar, Ponco Birowo, Rosalina Thuffi andhea Raden Muharram, Zulhulaifah Wa Ode, Rijal Subahar, Fatmawaty Yazid, Supri Irianti Handayani and Vivitri Dewi Prasasty. |
Endometrial Tissue; FSHR; Macaque; Proliferation Marker; RFSH |
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Science Publications |
16084217 |
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Article |
Q4 |
152 |
23000 |
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791 |
Elhidsi M., Fachrucha F., Irawan R.Y. |
57203157152;57224454767;57224450720; |
N-Acetylcysteine for coronavirus disease-19: A potential adjuvant therapy |
2021 |
Journal of Health Sciences |
11 |
1 |
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1 |
6 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107532673&doi=10.17532%2fjhsci.2020.1156&partnerID=40&md5=54f33bc66788c4c394abb216fff7bce9 |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia |
Elhidsi, M., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Fachrucha, F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Irawan, R.Y., Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia |
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) infection or known as coronavirus disease 2019 (COVID-19) is a highly infectious disease that has been declared as a world pandemic by WHO. Although the majority of patients only experience mild symptoms, older patients and those with comorbidities are in the risk of falling into critically ill and even death. This is thought to correlate with systemic inflammatory response and oxidative stress imbalance. N-acetylcysteine (NAC) is recognized as a potent mucolytic, yet its lesser-known function as an antioxidant is a precursor of glutathione. Basic aspects and either in vivo or in vitro studies showed various mechanisms of NAC acting as a counterbalance in viral infections and its role in decreasing inflammation and oxidative stress. High-dose NAC is reported to be effective as an antioxidant in pneumonia, influenza, sepsis, and acute respiratory distress syndrome. Early evidence in COVID-19 patients showed that NAC could be beneficial. This review gives the scientific background in considering NAC as an adjuvant treatment for COVID-19. © 2021. Mia Elhidsi et al;. All Rights Reserved. |
Antioxidant; coronavirus disease-19; glutathione; N-acetylcysteine; oxidative stress |
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University of Sarajevo - Faculty of Health Studies |
22327576 |
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Article |
Q4 |
112 |
28273 |
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804 |
Wicaksana P., Kurniati N., Pardede S. |
57193446457;36473260300;57210394278; |
Dyslipidemia among HIV-positive children receiving antiretroviral therapy in Indonesia |
2021 |
HIV and AIDS Review |
20 |
1 |
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46 |
51 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106294127&doi=10.5114%2fhivar.2021.105086&partnerID=40&md5=1f2028e2d19b8667b0fe6419e86d0dfd |
Department of Child Health, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia |
Wicaksana, P., Department of Child Health, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia; Kurniati, N., Department of Child Health, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia; Pardede, S., Department of Child Health, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia |
Introduction: Antiretroviral (ARV) therapy has changed the status of human immunodeficiency virus (HIV) infection from a high-mortality disease into a chronic one. One of the consequences of long-term use of ARV medications is dyslipidemia, which may progress to cardiovascular disease in the future. The aim of the study was to measure the rate of dyslipidemia among HIV-infected children receiving ARV therapy and related risk factors. Material and methods: A cross-sectional study was conducted at pediatric outpatient clinic, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, from January to July 2019. Lipid profile was examined on 96 eligible subjects and data regarding nutritional status, clinical stage at diagnosis, latest immunosuppression status, latest viral load (VL) value, and latest ARV combination used were obtained from medical records. Bivariate and multivariate analysis were performed to find the association between dependent and independent variables using SPSS version 22. Results: Of 96 subjects included, 52 (54.2%) subjects experienced dyslipidemia. The prevalence of dyslipidemia among those with second-line (containing protease inhibitors) and first-line (containing non-nucleoside reverse transcriptase inhibitors) ARV therapy were 80% and 39%, respectively. The use of second-line ARV therapy was associated with 6.3 times (p < 0.01; 95% CI: 2.4-17.1) increased risk of dyslipidemia compared to first-line ARV therapy. Conclusions: Prevalence of dyslipidemia among HIV-positive children on ARV was high with second-line ARV therapy being a risk factor. © 2021 Termedia Publishing House Ltd.. All rights reserved. |
Children; Dyslipidemia; HAART; HIV; Protease inhibitors |
abacavir; antiretrovirus agent; cholesterol; efavirenz; emtricitabine; high density lipoprotein; lamivudine; lopinavir plus ritonavir; low density lipoprotein; nevirapine; tenofovir; triacylglycerol; zidovudine; adolescent; Article; child; controlled study; cross-sectional study; dyslipidemia; female; highly active antiretroviral therapy; human; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; hypertriglyceridemia; immune deficiency; Indonesia; lipid fingerprinting; major clinical study; male; nutritional status; pediatric hospital; preschool child; prevalence; school child; virus load |
Termedia Publishing House Ltd. |
17301270 |
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Article |
Q4 |
156 |
22602 |
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