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815 |
Permata T.B.M., Sekarutami S.M., Nuryadi E., Giselvania A., Gondhowiardjo S. |
57197808751;56576294500;57197806814;57217201891;6508327402; |
Rapid advancement in cancer genomic big data in the pursuit of precision oncology |
2021 |
Medical Journal of Indonesia |
30 |
1 |
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81 |
85 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105003444&doi=10.13181%2fmji.rev.204250&partnerID=40&md5=ac20a978c8162343bd2dd077ffd5908e |
Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Permata, T.B.M., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sekarutami, S.M., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Nuryadi, E., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Giselvania, A., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Gondhowiardjo, S., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
In the current big data era, massive genomic cancer data are available for open access from anywhere in the world. They are obtained from popular platforms, such as The Cancer Genome Atlas, which provides genetic information from clinical samples, and Cancer Cell Line Encyclopedia, which offers genomic data of cancer cell lines. For convenient analysis, user-friendly tools, such as the Tumor Immune Estimation Resource (TIMER), which can be used to analyze tumor-infiltrating immune cells comprehensively, are also emerging. In clinical practice, clinical sequencing has been recommended for patients with cancer in many countries. Despite its many challenges, it enables the application of precision medicine, especially in medical oncology. In this review, several efforts devoted to accomplishing precision oncology and applying big data for use in Indonesia are discussed. Utilizing open access genomic data in writing research articles is also described. © 2021 Authors. |
Cancer genetic database; Oncology; Personalized medicine |
adult; big data; cancer cell line; clinical practice; controlled study; genetic database; human; human cell; immunocompetent cell; Indonesia; personalized medicine; review; writing |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Review |
Q4 |
164 |
21905 |
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816 |
Pratomo I.P., Ariane A., Tedjo A., Heryanto R., Paramita R.I. |
57192904477;57210643323;57189320451;23392757600;54882436900; |
Xanthine oxidase inhibition in sars-cov-2 infection: The mechanism and potency of allopurinol and febuxostat in covid-19 management |
2021 |
Medical Journal of Indonesia |
30 |
1 |
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75 |
80 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104949199&doi=10.13181%2fmji.rev.204641&partnerID=40&md5=689e842e1dfa9cde24da9c6f8f7bbee1 |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Universitas Indonesia Hospital, Depok, Indonesia; Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunksumo Hospital, Jakarta, Indonesia; Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Drug Development Research Cluster, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas IPB, Bogor, Indonesia; Tropical Biopharmaca Research Center, Universitas IPB, Bogor, Indonesia |
Pratomo, I.P., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Universitas Indonesia Hospital, Depok, Indonesia, Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ariane, A., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunksumo Hospital, Jakarta, Indonesia; Tedjo, A., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Drug Development Research Cluster, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Heryanto, R., Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas IPB, Bogor, Indonesia, Tropical Biopharmaca Research Center, Universitas IPB, Bogor, Indonesia; Paramita, R.I., Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
The number of coronavirus disease 2019 (COVID-19) infection cases has been increasing globally, including in Indonesia. Definitive therapy for COVID-19 has not yet been found; hence, repurposed drugs for COVID-19 have been considered and have been practiced by several researchers in the world. This literature review investigates the action of xanthine oxidase as a component of the biomolecular pathway against severe acute respiratory syndrome-related coronavirus-2, the cause of COVID-19, and describes the mechanism and potential of uric acid drugs (allopurinol and febuxostat) as prophylaxis and curative therapy for COVID-19. © 2020 Authors. |
COVID-19; Free radicals; Uric acid; Xanthine oxidase |
allopurinol; C reactive protein; febuxostat; free radical; gamma interferon; interleukin 2; interleukin 6; reactive oxygen metabolite; uric acid; xanthine oxidase; animal model; coronavirus disease 2019; cytokine production; cytokine storm; drug potency; epithelium; influenza; mouse; neutrophil; nonhuman; oxidative stress; pathogenesis; poultry; respiratory virus; Review; Severe acute respiratory syndrome coronavirus 2; virus infection |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Review |
Q4 |
164 |
21905 |
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821 |
Wanandi S.I., Arumsari S., Afitriyansyah E., Syahrani R.A., Dewantara I.R., Nurachman L.A., Amin I.F., Haryono P.D., Budiman K., Sugiharta A.J., Remedika A.A., Taufikulhakim F.H., Iswanti F.C., Lee J.Y., Banerjee D. |
36099320700;57193202336;57223005545;57204103147;57223018344;57222663184;57188973524;57223016376;57223010670;57223013711;57223000993;57222619312;57192920851;57223019852;7202633380; |
Elevated extracellular co2 level affects the adaptive transcriptional response and survival of human peripheral blood mononuclear cells toward hypoxia and oxidative stress |
2021 |
Medical Journal of Indonesia |
30 |
1 |
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5 |
12 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104485331&doi=10.13181%2fmji.oa.203810&partnerID=40&md5=bf8dedf67718ab440cf4f665b5af2f83 |
Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Molecular Biology and Proteomics Core Facilities, Indonesian Medical and Education Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Biomedical Science Master Program, Rutgers-Robert Wood Johnson Medical SchoolNJ, United States; USAID Research Innovation Fellowship 2017, Washington, DC, United States; Department of Pharmacology, Rutgers-Robert Wood Johnson Medical SchoolNJ, United States |
Wanandi, S.I., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Molecular Biology and Proteomics Core Facilities, Indonesian Medical and Education Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Arumsari, S., Molecular Biology and Proteomics Core Facilities, Indonesian Medical and Education Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Afitriyansyah, E., Molecular Biology and Proteomics Core Facilities, Indonesian Medical and Education Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Syahrani, R.A., Molecular Biology and Proteomics Core Facilities, Indonesian Medical and Education Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Dewantara, I.R., Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Nurachman, L.A., Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Amin, I.F., Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Haryono, P.D., Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Budiman, K., Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sugiharta, A.J., Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Remedika, A.A., Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Taufikulhakim, F.H., Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Iswanti, F.C., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Molecular Biology and Proteomics Core Facilities, Indonesian Medical and Education Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Lee, J.Y., Biomedical Science Master Program, Rutgers-Robert Wood Johnson Medical SchoolNJ, United States, USAID Research Innovation Fellowship 2017, Washington, DC, United States; Banerjee, D., Department of Pharmacology, Rutgers-Robert Wood Johnson Medical SchoolNJ, United States |
BACKGROUND High carbon dioxide (CO2 ) level from indoor environments, such as classrooms and offices, might cause sick building syndrome. Excessive indoor CO2 level increases CO2 level in the blood, and over-accumulation of CO2 induces an adaptive response that requires modulation of gene expression. This study aimed to investigate the adaptive transcriptional response toward hypoxia and oxidative stress in human peripheral blood mononuclear cells (PBMCs) exposed to elevated CO2 level in vitro and its association with cell viability. METHODS PBMCs were treated in 5% CO2 and 15% CO2, representatives a high COâ‚‚ level condition for 24 and 48 hours. Extracellular pH (pHe) was measured with a pH meter. The levels of reactive oxygen species were determined by measuring superoxide and hydrogen peroxide with dihydroethidium and dichlorofluorescin-diacetate assay. The mRNA expression levels of hypoxia-inducible factor (HIF)-1α, HIF-2α, nuclear factor (NF)-κB, and manganese superoxide dismutase (MnSOD) were analyzed using a real-time reverse transcriptase-polymerase chain reaction (qRT-PCR). Cell survival was determined by measuring cell viability. RESULTS pHe increased in 24 hours after 15% COâ‚‚ treatment, and then decreased in 48 hours. Superoxide and hydrogen peroxide levels increased after the 24-and 48-hour of high COâ‚‚ level condition. The expression levels of NF-κB, MnSOD, HIF-1α, and HIF-2α decreased in 24 hours and increased in 48 hours. The increased antioxidant mRNA expression in 48 hours showed that the PBMCs were responsive under high CO2 conditions. Elevated CO2 suppressed cell viability significantly in 48 hours. CONCLUSIONS After 48 hours of high COâ‚‚ level condition, PBMCs showed an upregulation in genes related to hypoxia and oxidative stress to overcome the effects of CO2 elevation. © 2021 Authors. |
Elevated CO2; Extracellular pH; Oxidative stress; PBMC; Reactive oxygen species |
carbon dioxide; hydroethidine; hypoxia inducible factor 1alpha; hypoxia inducible factor 2alpha; immunoglobulin enhancer binding protein; manganese superoxide dismutase; messenger RNA; reactive oxygen metabolite; adult; Article; cell survival; cell viability; controlled study; extracellular space; gene expression; genetic transcription; human; human cell; human experiment; hypoxia; male; mRNA expression level; normal human; oxidative stress; peripheral blood mononuclear cell; pH; real time reverse transcription polymerase chain reaction; upregulation; young adult |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Article |
Q4 |
164 |
21905 |
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822 |
Ramlan A.A.W., Ratnaningrum A., Marsaban A.H.M. |
57195941841;57223018172;57195383833; |
A randomized controlled trial of infraorbital block using ketamine 1% for intra-and postoperative analgesia in children for ambulatory cleft lip correction |
2021 |
Medical Journal of Indonesia |
30 |
1 |
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33 |
38 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104479826&doi=10.13181%2fmji.oa.204395&partnerID=40&md5=c08932eaa2373ffcc535ff0eadd8e55b |
Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anesthesiology, Fatmawati General Hospital, Jakarta, Indonesia |
Ramlan, A.A.W., Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ratnaningrum, A., Department of Anesthesiology, Fatmawati General Hospital, Jakarta, Indonesia; Marsaban, A.H.M., Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND In Indonesia, cleft lip correction surgery is often done as a social program in remote areas with limited resources. This study aimed to assess the effectiveness of ketamine, a cheaper and more accessible alternative, as a local analgesia in infraorbital block and to determine the possibility of ketamine as an alternative local analgesic drug for intraoperative and postoperative periods. METHODS This was a randomized controlled trial in children aged 2 months to 5 years who underwent cleft lip correction surgery at Cipto Mangunkusumo Hospital in 2016. Subjects were randomly divided into two groups: ketamine and bupivacaine. Standard general anesthesia with endotracheal intubation was performed in each group. Bilateral intraoral infraorbital block was performed using ketamine 1% 0.5 ml or bupivacaine 0.25% 0.5 ml. Postoperative evaluation includes pain scores based on the face, leg, activity, cry, and consolability (FLACC) scale and analgesic duration. RESULTS A total of 36 subjects were enrolled in this study, with 18 in each group. Both groups received the same total amount of fentanyl addition intraoperatively (p = 1). The postoperative FLACC pain scale scores between the two groups were not different, with p>0.05 in every measurement. The mean duration of postoperative analgesia in the ketamine group was longer than the bupivacaine group (15–13.49 hours, p = 0.031). CONCLUSIONS Infraorbital block with 1% ketamine 0.5 mg/kg was similarly effective for intraoperative and postoperative analgesia but had a longer duration than that with 0.25% bupivacaine 0.5 ml in ambulatory cleft lip correction. © 2021 Authors. |
Cleft lip; Ketamine; Postoperative pain |
bupivacaine; epinephrine; fentanyl; ketamine; paracetamol; sevoflurane; Article; breathing rate; child; cleft lip; cleft palate; clinical article; controlled study; endotracheal intubation; female; FLACC scale; follow up; general anesthesia; hemodynamics; human; infant; infraorbital nerve; infraorbital nerve block; intraoperative period; male; nerve block; pain assessment; postoperative analgesia; postoperative pain; pulse rate; randomized controlled trial; single blind procedure; telephone interview; visual analog scale |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Article |
Q4 |
164 |
21905 |
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823 |
Sarika D.T., Louisa M., Rozaliyani A., Evelina, Susiyanti M. |
57223018187;41461551400;57203065912;57223007552;19640377300; |
Efficacy of adjuvant intrastromal and combination of intrastromal and intracameral voriconazole in aspergillus fumigatus-induced moderate fungal keratitis in rabbits |
2021 |
Medical Journal of Indonesia |
30 |
1 |
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13 |
19 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104464172&doi=10.13181%2fmji.oa.203726&partnerID=40&md5=6021b6878c47eb4ccde69bba65f51abb |
Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Clinical Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Sarika, D.T., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of Clinical Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rozaliyani, A., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Evelina, Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Susiyanti, M., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND There is no in vivo evidence for the effectiveness of adjuvant intrastromal and combination of intrastromal and intracameral voriconazole (VCZ) for treating Aspergillus fumigatus keratitis. This study aimed to compare the efficacy of both agents against it. METHODS A randomized, masked, controlled experimental study was conducted on 11 albino New Zealand white rabbits in which moderate fungal keratitis was induced by inoculating spores of A. fumigatus to the cornea. The rabbits were allocated into 3 groups: 50 μg/0.1 ml intrastromal VCZ injection, 50 μg/0.1 ml intrastromal and intracameral VCZ injections, and topical VCZ (control). The treatment was given 5 days after inoculation. Epithelial defect, infiltrate size, corneal ulcer depth, and hypopyon were evaluated clinically. Histopathological and mycological examinations were also done 14 days after treatment. RESULTS All rabbits in the adjuvant treatment groups demonstrated a tendency of a better clinical response with decreasing size of epithelial defect (p = 0.679) and infiltrate (p = 0.755) than in the control group. Direct microscopy, corneal culture, and chop corneal tissue culture were still positive in most of the rabbits from all groups. Histopathological examination showed an increase of inflammatory cells after treatment in all groups, especially in rabbits which were inoculated with A. fumigatus spores in both eyes. CONCLUSIONS An adjuvant combination of intrastromal and intracameral VCZ showed a tendency of better clinical response for A. fumigatus-induced moderate fungal keratitis in rabbits. © 2021 Authors. |
Aspergillus fumigatus; Fungal keratitis; Intrastromal; Voriconazole |
eye drops; ketamine; pentobarbital; potassium hydroxide; prednisone acetate; tetracaine; voriconazole; xylazine; animal experiment; animal model; animal tissue; Article; Aspergillus fumigatus; controlled study; cornea injury; cornea ulcer; corneal scraping; disk diffusion; drug efficacy; follow up; fungal examination; histopathology; hypopyon; inflammation; intrastromal drug administration; keratectomy; keratomycosis; Leporidae; male; nonhuman; treatment response |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Article |
Q4 |
164 |
21905 |
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826 |
Irawati Y., Soedarman S., Arianti A., Widyasari A., Reksodiputro M.H. |
57201260313;57222867991;57201999421;57280734100;35090488800; |
Multiple approaches for managing complex ophthalmic blunt trauma: A case report |
2021 |
International Medical Case Reports Journal |
14 |
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205 |
210 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104124100&doi=10.2147%2fIMCRJ.S304193&partnerID=40&md5=1d5a9d9b836b19267fc2e128d84efc72 |
Division of Plastic and Reconstructive Surgery, Department of Ophthalmology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Orbital and Oculoplastic Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Vitreo- Retina Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Neuro- Ophthalmology Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Division of Plastic Reconstruction, Department of Ear, Nose and Throat, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Irawati, Y., Division of Plastic and Reconstructive Surgery, Department of Ophthalmology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, Orbital and Oculoplastic Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Soedarman, S., Vitreo- Retina Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Arianti, A., Neuro- Ophthalmology Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Widyasari, A., JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Reksodiputro, M.H., Division of Plastic Reconstruction, Department of Ear, Nose and Throat, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: Ophthalmic trauma is defined as injuries affecting the ocular structures, including the globe, eyelid, lacrimal system, and surrounding orbital walls. Blunt trauma acts as the leading cause of injury and it may affect both the anterior and posterior parts of the globe. Prompt diagnosis, early management, and sustained follow-up are mandatory for an optimal outcome. Purpose: This report presents a one-step surgery management process for an intricate case of blunt facial trauma with complex ophthalmic and nasal injury. Patients and Methods: A 45-year-old male with blunt force trauma of the left eye from a wooden block, suffered from naso-orbital-ethmoidal fractures, eyelid laceration with canalicular, close-globe injuries of traumatic cataract and vitreous hemorrhage with retinal detachment. A simultaneous one-step surgery was performed by a trauma team of ophthalmological and ENT surgeons during the height of the COVID-19 pandemic to lessen the risk of cross-transmission. After ruling out the possibility of open-globe rupture, traumatic cataract extraction, retinal detachment surgery, the repair of an eyelid laceration with canalicular involvement, and septorhinoplasty were performed on concomitantly. Results: Anatomical success was achieved for the repair of the nasoorbitoethmoidal (NOE) type II fracture and close-globe injuries, including the anatomical reattachment of the retina. However, the functional outcome remained unsatisfactory. Visual acuity failed to show further improvement at a later follow-up. Traumatic optic neuropathy was, at the final follow-up, considered to be the cause of the suboptimal visual acuity. Conclusion: A single-step multi-procedure for a complex ophthalmic blunt trauma, as demonstrated in this case, may be beneficial for reducing the complications that might arise due to treatment delay. The complex nature of the injury, however, creates the higher possibility for residual post-operative complications. Risks of residual functional impairment should be considered in such complex trauma prior to surgery, to determine the surgical prognostic value and provide appropriate consent to the patient. © 2021 Irawati et al. |
Blunt trauma; Canalicular laceration; Closed-globe injury; Facial injury; Nasal fracture; Ocular trauma |
adult; Article; blunt trauma; case report; cataract; clinical article; clinical examination; conjunctival hemorrhage; crackle; epistaxis; ethmoid bone; eye injury; eyelid closure; eyelid disease; eyelid reconstruction; face fracture; human; hyphema; Indonesia; laceration; lens implantation; male; middle aged; nasopharyngeal swab; nose injury; nose septum reconstruction; occupational accident; orbit fracture; postoperative care; retina detachment; ultrasound; visual acuity; vitrectomy; vitreous hemorrhage |
Dove Medical Press Ltd |
1179142X |
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Article |
Q4 |
198 |
19482 |
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850 |
Prasetyono T.O.H. |
26646993900; |
Indonesian plastic surgeons’ attitude during early period of the covid-19 pandemic |
2021 |
Archives of Craniofacial Surgery |
22 |
1 |
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17 |
25 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102865686&doi=10.7181%2facfs.2020.00451&partnerID=40&md5=a8e6d8b196710b9f9880783cbcb51fba |
Division of Plastic Surgery, Department of Surgery, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Prasetyono, T.O.H., Division of Plastic Surgery, Department of Surgery, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: This study aims to report how the practice of plastic surgeons and their attitude was during the first measure period of coronavirus disease 2019 (COVID-19) pandemic. Methods: A survey study was held among members of the Indonesian Association of Plastic Re-constructive and Aesthetic Surgeons during week 5 after the first report of COVID-19. A 10 multi-ple-choice questions (MCQs) and 1 essay covered key questions on the area of surgery and operating room, clinics, internal meeting, and consultation. The only open-ended question relates to the last MCQ addresses a future “flipped” medical practice. Results: Response rate was 45.6% among 228 members, with 89.4% did no practice or limited their service to emergency and urgent cases only. Only 1.9% kept their official meeting as usual, while the majority modified it. The practice in the operating theatre and clinic were also altered to comply with the measures; with 21.2% from the total respondents only allowed patients with ex-posure to come for visit after taking 14 days of self-quarantine. Teleconsultation was practiced by 50% of the respondents, while 41.3% agreed and 10.6% disagreed upon the future “flipped” medical practice. Conclusion: In general plastic surgeons have made supportive actions during the pandemic. Surgery was performed with all precautions at the utmost as a reflection of high alert of viral infec-tion. Teleconsultation has been embraced via existing social media. Agreement upon the future “flipped” medical practice is reasonable. All in all, the actions were considered as most relevant. © 2021 Korean Cleft Palate-Craniofacial Association. |
Pandemics; Surgery, plastic; Surveys and questionnaires; Viruses |
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Korean Cleft Palate-Craniofacial Association |
22871152 |
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Article |
Q4 |
192 |
19848 |
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851 |
Yunir E., Kurniawan F., Rezaprasga E., Wijaya I.P., Suroyo I., Matondang S., Irawan C., Soewondo P. |
36520254800;57202309006;57222478699;57193731572;57204106272;57192085914;28767651600;23475336100; |
Autologous Bone-Marrow vs. Peripheral Blood Mononuclear Cells Therapy for Peripheral Artery Disease in Diabetic Patients |
2021 |
International Journal of Stem Cells |
14 |
1 |
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21 |
32 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102786540&doi=10.15283%2fijsc20088&partnerID=40&md5=91f35aa55f974c266100f150613cc086 |
Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Yunir, E., Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Kurniawan, F., Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rezaprasga, E., Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Wijaya, I.P., Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Suroyo, I., Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Matondang, S., Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Irawan, C., Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Soewondo, P., Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Diabetes mellitus (DM) remains one of the most important risk factors for peripheral artery disease (PAD), with approximately 20% of DM patients older than 40 years old are affected with PAD. The current standard management for severe PAD is endovascular intervention with or without surgical bypass. Unfortunately, up to 40% of patients are unable to undergo these revascularization therapies due to excessive surgical risk or adverse vascular side effects. Stem cell therapy has emerged as a novel therapeutic strategy for these ‘no-option’ patients. Several types of stem cells are utilized for PAD therapy, including bone marrow mononuclear cells (BMMNC) and peripheral blood mononuclear cells (PBMNC). Many studies have reported the safety of BMMNC and PBMNC, as well as its efficacy in reducing ischemic pain, ulcer size, pain-free walking distance, ankle-brachial index (ABI), and transcutaneous oxygen pressure (TcPO2). However, the capacity to establish the efficacy of reducing major amputation rates, amputation free survival, and all-cause mortality is limited, as shown by several randomized placebo-controlled trials. The present literature review will focus on comparing safety and efficacy between BMMNC and PBMNC as cell-based management in diabetic patients with PAD who are not suitable for revascularization therapy. Copyright © 2021 by the Korean Society for Stem Cell Research |
Bone marrow mononuclear cells; Diabetes mellitus; Peripheral artery disease; Peripheral blood mononuclear cells; Stem cell therapy |
Article; autologous bone marrow transplantation; bone marrow derived mononuclear cell; clinical trial (topic); comparative effectiveness; diabetes mellitus; diabetic patient; human; patient safety; peripheral blood mononuclear cell; peripheral occlusive artery disease; stem cell transplantation |
Sungkyunkwan University |
20053606 |
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Article |
Q4 |
569 |
8885 |
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854 |
Kirana A.N., Prafiantini E., Hardiany N.S. |
57222361321;57193088368;57192910605; |
Protein intake and loss of proteostasis in the eldery |
2021 |
Ukrainian Biochemical Journal |
93 |
1 |
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30 |
39 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102434761&doi=10.15407%2fubj93.01.030&partnerID=40&md5=e09be01091937944ac8ad3197ad54b2c |
Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Indonesia; Center of Hypoxia and Oxidative Stress Studies, Faculty of Medicine, Universitas Indonesia, Indonesia |
Kirana, A.N., Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Prafiantini, E., Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Hardiany, N.S., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Indonesia, Center of Hypoxia and Oxidative Stress Studies, Faculty of Medicine, Universitas Indonesia, Indonesia |
Ageing is a process of declining bodily function and a major risk factor of chronic diseases. The declining bodily function in ageing can cause loss of proteostasis (protein homeostasis), which is a balance between protein synthesis, folding, modification and degradation. For the elderly, adequate protein intake is necessary to prevent sarcopenia, frailty, fracture and osteoporosis as well as reduced resistance to infection. However, increasing the protein intake can enhance the risk of oxidized protein formation, loss of proteostasis and degenerative disorder occurrence. On the other hand, several studies show that protein restriction would increase longevity. The aim of this review was to explain the importance of determining the right amount and composition of protein intake for the elderly. Oxidative stress and molecular mechanism of proteostasis loss in ageing cells as well as its suppression pathway by protein restriction are discussed in this review. © 2021 Kirana A. N. et al. |
Ageing; Dietary proteins; MTOR; Oxidative stress; Proteostasis loss |
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Palladin Institute of Biochemistry of the NASU |
24094943 |
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Article |
Q4 |
173 |
21241 |
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863 |
Sahlan M., Tejamaya M., Arbianti R., Baruji T., Adawiyah R., Hermansyah H. |
57189182661;55295863200;55897945700;57222240819;57208658742;15759436800; |
The effects of nano-casein encapsulation and productions of a controlled-release on eugenol containing bio-pesticide toxicity |
2021 |
Key Engineering Materials |
874 KEM |
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115 |
127 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101971950&doi=10.4028%2fwww.scientific.net%2fKEM.874.115&partnerID=40&md5=6f6b175ce47bb2305dfbaffecf2240a3 |
Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia; Research Center of Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia; Department of Occupational Health and Safety, Faculty of Public Health, Universitas Indonesia, Depok, 16424, Indonesia; Center of Bioindustry Technology, Agency for The Assessment and Application of Technology, Jakarta, 10340, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Sahlan, M., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia, Research Center of Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia; Tejamaya, M., Department of Occupational Health and Safety, Faculty of Public Health, Universitas Indonesia, Depok, 16424, Indonesia; Arbianti, R., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia; Baruji, T., Center of Bioindustry Technology, Agency for The Assessment and Application of Technology, Jakarta, 10340, Indonesia; Adawiyah, R., Research Center of Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia, Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Hermansyah, H., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia |
The concern against long-term health and environmental adverse effects of synthetic pesticides has encouraged the development of bio-pesticides. Eugenol, a major constituent of clove oil, has been proven as potential bio-pesticides. However, evaporation and photosensitive properties of Eugenol needs to be controlled. Nano-encapsulation is a promising method that can preserve eugenol from evaporating and photodegradation. This study aims to investigate the production of a controlled-release of eugenol in casein micelle as well as the effects of nano-encapsulation on Eugenol Containing Biopesticide (ECB) toxicity against Artemia salina sp. Brine Shrimp Lethality Test (BSLT) was implemented to investigate effect of nano-encapsulation on ECB and the Response Surface Methodology was used to optimize the formula to investigate the production of a controlled-release of eugenol. The optimum condition revealed loading capacity and encapsulation efficiency response for 64.67% and 79.64%, respectively. The average diameter of the obtained nanocapsule-eugenol (NCE) was 179.83 nm. Release study was performed at 40 °C that represent as pesticide applied in farm, revealed that casein micelle capsule could delayed the release of eugenol. A cytotoxicity assay showed that the NCE has 21 times more effective compared with eugenol only. It was found that nano encapsulated ECB was statistically more toxic than ECBsuspension (without nano encapsulation) with a confidence level of 95%. Lethal Concentration 50 (LC50) of nano-ECB was 0.264 μg/L while LC50 of ECB-suspension was 4.445 μg/L. The increase of toxic properties after nano-encapsulation by casein could be explained by the increase of eugenol stability. Thus nano-encapsulation can be proposed as a method for improving the bio-pesticide ability of eugenol. © 2021 Trans Tech Publications Ltd, Switzerland. |
Biopesticide; BSLT1; Casein; Controlled-release; Eugenol; Nano encapsulation; Optimizing |
Casein; Dairies; Micelles; Suspensions (fluids); Toxicity; Brine shrimp lethalities; Cytotoxicity assays; Encapsulation efficiency; Investigate effects; Lethal concentration; Photosensitive properties; Response surface methodology; Synthetic pesticides; Pesticide effects |
Trans Tech Publications Ltd |
10139826 |
9783035737639 |
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Conference Paper |
Q4 |
175 |
21056 |
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