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883 |
Harimurti K., Saldi S.R.F., Dewiasty E., Alfarizi T., Dharmayuli M., Khoeri M.M., Paramaiswari W.T., Salsabila K., Tafroji W., Halim C., Jiang Q., Gamil A., Safari D. |
23473513200;55201904000;55257705500;57221853325;57221841113;55994827400;57221097580;57192272141;57118271600;57221850899;36028184700;57202388319;23493586700; |
Streptococcus pneumoniae carriage and antibiotic susceptibility among Indonesian pilgrims during the Hajj pilgrimage in 2015 |
2021 |
PLoS ONE |
16 |
1 January |
e0246122 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100423019&doi=10.1371%2fjournal.pone.0246122&partnerID=40&md5=49970f6f2918134dc220f4fd13977bed |
Clinical Epidemiology and Evidence-Based Medicine (CEEBM) Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Center of Hajj Health, Ministry of Health, Jakarta, Indonesia; Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Pfizer Indonesia, Jakarta, Indonesia; Pfizer Inc., Collegeville, PA, United States; Pfizer Inc., Emerging Markets Medical and Scientific Affairs, Dubai, United Arab Emirates |
Harimurti, K., Clinical Epidemiology and Evidence-Based Medicine (CEEBM) Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Saldi, S.R.F., Clinical Epidemiology and Evidence-Based Medicine (CEEBM) Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Dewiasty, E., Clinical Epidemiology and Evidence-Based Medicine (CEEBM) Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Alfarizi, T., Center of Hajj Health, Ministry of Health, Jakarta, Indonesia; Dharmayuli, M., Center of Hajj Health, Ministry of Health, Jakarta, Indonesia; Khoeri, M.M., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Paramaiswari, W.T., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Salsabila, K., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Tafroji, W., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Halim, C., Pfizer Indonesia, Jakarta, Indonesia; Jiang, Q., Pfizer Inc., Collegeville, PA, United States; Gamil, A., Pfizer Inc., Emerging Markets Medical and Scientific Affairs, Dubai, United Arab Emirates; Safari, D., Eijkman Institute for Molecular Biology, Jakarta, Indonesia |
The Hajj is an annual pilgrimage to Mecca and one of the largest gathering of people in the world. Most Indonesian pilgrims are senior adults and elderly adults, who are more prone to acquire infections during the Hajj ritual. The aims of this study are to investigate the dynamics of Streptococcus pneumoniae colonization and to investigate antibiotic susceptibility of pneumococcal strains in Indonesian pilgrims. This was a prospective multi-site longitudinal study in Indonesian hajj pilgrims aged >18 years old in the year 2015. Nasopharyngeal swabs were collected from the same subject before departure and upon arrival at the airport. S. pneumoniae was identified using conventional and molecular approach, while antibiotic susceptibility was determined using a disk diffusion method. Among 813 Hajj pilgrims who were enrolled from five sites in this study, the prevalence of S. pneumoniae carriage rates before- and after-the Hajj were 8.6% (95% CI 6.7–10.5%) and 8.2% (95% CI 6.4–10.1%), (p value: 0.844) respectively. Serotype 16F, 6A/6B, 3, 18, and 23F were the five most prevalent serotypes before Hajj, whereas serotypes 3, 34, 13, 4, and 23F were the most prevalent serotypes after Hajj. Serotype 3 was identified as most acquired serotype during Hajj in Indonesian pilgrim. There was an increase in the percentage of isolates susceptible to co-trimoxazole after Hajj (42.9% versus 57.4%). The study provided an overview of the change of dynamics of S. pneumoniae serotype acquisition in Indonesian Hajj Pilgrims. Along with data of vaccination serotypes coverage and antimicrobial susceptibility, these findings may contribute to recommendation of vaccination and treatment policies in the future. © 2021 Harimurti et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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chloramphenicol; clindamycin; cotrimoxazole; erythromycin; penicillin derivative; tetracycline; antiinfective agent; adult; airport; antibiotic sensitivity; Article; bacterial colonization; bacterial strain; bacterium isolate; controlled study; disk diffusion; female; human; Indonesian; longitudinal study; male; nasopharyngeal swab; nonhuman; prospective study; serotype; Streptococcus pneumoniae; adolescent; antibiotic resistance; clinical trial; crowding (area); growth, development and aging; heterozygote; Indonesia; isolation and purification; microbial sensitivity test; microbiology; middle aged; multicenter study; nasopharynx; pneumococcal infection; Streptococcus pneumoniae; Adolescent; Adult; Anti-Bacterial Agents; Carrier State; Crowding; Drug Resistance, Bacterial; Female; Humans; |
Public Library of Science |
19326203 |
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33497410 |
Article |
Q1 |
990 |
4434 |
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885 |
Prayitno A., Supriyatno B., Munasir Z., Karuniawati A., Hadinegoro S.R.S., Prihartono J., Safari D., Sundoro J., Khoeri M.M. |
57193342301;37068046400;7801694370;54886816200;57226218772;6602605635;23493586700;49762130000;55994827400; |
Pneumococcal nasopharyngeal carriage in Indonesia infants and toddlers post-PCV13 vaccination in a 2+1 schedule: A prospective cohort study |
2021 |
PLoS ONE |
16 |
1 January |
e0245789 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100392996&doi=10.1371%2fjournal.pone.0245789&partnerID=40&md5=cb78eb658b86a8f3be7a35fe8b7fd3cc |
Department of Pediatrics, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Microbiology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Molecular Bacteriology, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Indonesian Technical Advisory Group on Immunization, Jakarta, Indonesia |
Prayitno, A., Department of Pediatrics, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Supriyatno, B., Department of Pediatrics, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Munasir, Z., Department of Pediatrics, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Karuniawati, A., Department of Microbiology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Hadinegoro, S.R.S., Department of Pediatrics, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Prihartono, J., Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Safari, D., Molecular Bacteriology, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Sundoro, J., Indonesian Technical Advisory Group on Immunization, Jakarta, Indonesia; Khoeri, M.M., Molecular Bacteriology, Eijkman Institute for Molecular Biology, Jakarta, Indonesia |
Background The PCV13 immunization demonstration program began in October 2017 in Indonesia. The aim of this study is to assess the dynamic changes of pneumococcal serotype before and after PCV13 administration, with two primary and one booster doses. Methods The prospective cohort study was conducted as a follow up study measuring the impact of PCV13 demonstration program by the Indonesian Ministry of Health in Lombok Island, West Nusa Tenggara, Indonesia, from March 2018 to June 2019. The subjects were two-month-old healthy infants who were brought to the primary care facility for routine vaccination and followed until 18 months of age. We use convenience sampling method. There were 115 infants in the control group and 118 infants in the vaccine group, and the PCV immunization was given on a 2+1 schedule. Nasopharyngeal (NP) swabs were collected four times during the vaccination periods by trained medical staff. Specimens were analyzed by culture methods to detect S. pneumonia colonization and multiplex polymerase chain reaction (mPCR) to determine serotype. The most frequently detected serotypes will be named as dominant serotypes. Descriptive analysis of demographic characteristics, the prevalence of overall and serotype colonization, and the distribution of serotypes were performed. The prevalence of both cohort groups were compared using chi-square test. Statistical significance was set at p < 0.05. Results Two hundred and thirty three infants age two months old were recruited, with 48.9% of the subjects were male and 51.1% of the subjects were female. Sociodemographic data in both cohort groups were relatively equal. Nasopharyngeal pneumococcal colonization before PCV13 administration occurred in 19.1% of the control and 22.9% of the vaccine group. The prevalence increased with increasing age in both groups. The prevalence of VT serotypes in control groups aged 2 months, 4 months, 12 months, and 18 months was 40.9%, 44.2%, 53.8%, and 54.3%, respectively, and in the vaccine group, 25.9%, 40.4%, 38.0%, and 22.6%, respectively. The most common VT serotypes in both groups were 6A/6B, 19F, 23F, and 14. The prevalence of VT serotypes decreased significantly compared to non-vaccine type serotypes after three doses of the PCV13 vaccine (p < 0.001). Another notable change was the decline in prevalence of serotype 6A/6B after PCV13 administration using the 2+1 schedule. Conclusions This study shows lower prevalence of VT and 6A/6B serotypes in the nasopharynx among children who were PCV13 vaccinated compared with those who were unvaccinated. The result from this study will be the beginning of future vaccine evaluation in larger population and longer period of study. © 2021 Prayitno et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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Pneumococcus vaccine; 13-valent pneumococcal vaccine; Pneumococcus vaccine; Article; bacterial colonization; bacterium carrier; cohort analysis; controlled study; demography; female; follow up; human; human experiment; Indonesia; infant; male; multiplex polymerase chain reaction; nasopharynx; normal human; population research; prevalence; primary medical care; serotype; sex ratio; social status; Streptococcus pneumoniae; toddler; trend study; vaccination; immunology; isolation and purification; microbiology; nose mucosa; pathogenicity; pneumococcal infection; preschool child; procedures; Streptococcus pneumoniae; Child, Preschool; Female; Humans; Indonesia; Infant; Male; Nasal Mucosa; Pneumococcal Infections; Pneumococcal Vaccines; Streptococcus pneumoniae; Vaccination |
Public Library of Science |
19326203 |
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33497405 |
Article |
Q1 |
990 |
4434 |
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890 |
Elliyanti A., Rustam R., Tofrizal T., Yenita Y., Susanto Y.D.B. |
57217097313;57210705603;57219663511;57221789235;57197866044; |
Evaluating the natrium iodide symporter expressions in thyroid tumors |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
B |
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18 |
23 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100161267&doi=10.3889%2foamjms.2021.5534&partnerID=40&md5=f5dd69104ea66dab03a6a98ac2928162 |
Department of Medical Physics, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Division of Nuclear Medicine, Department of Radiology, Dr. M.Djamil Hospital, Padang, Indonesia; Department of Surgery, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Department of Pathology Anatomy, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Elliyanti, A., Department of Medical Physics, Faculty of Medicine, Universitas Andalas, Padang, Indonesia, Division of Nuclear Medicine, Department of Radiology, Dr. M.Djamil Hospital, Padang, Indonesia; Rustam, R., Department of Surgery, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Tofrizal, T., Department of Pathology Anatomy, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Yenita, Y., Department of Pathology Anatomy, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Susanto, Y.D.B., Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND: Decreased Natrium iodide symporter (NIS) expression levels or diminished NIS targeting thyroid cancer cells’ plasma membrane leads to radioiodine-refractory disease. AIM: The aim of this study was to analyze the NIS expression in thyroid tumors. MATERIALS AND METHODS: The samples were thyroid tissues of patients who underwent surgery for a thyroid tumor. The tissues were processed for NIS protein expressions by immunohistochemistry (IHC) and Western blot (WB). Graves’ disease samples were used as positive controls. The samples were incubated without the primary antibody, and they were used as negative controls for IHC examination. Na+/K+ ATPase was a plasma membrane protein marker in the WB procedure. RESULTS: Twenty-nine samples were assessed for NIS protein. All of them showed the expression in the cytoplasm with intensity 1+ to 3+ with Allred score 3-8. Fourteen out of 29 cases (48.2%) showed NIS cytoplasm staining intensity ≥2+ consist of 10 papillary thyroid cancer (PTC), three follicular thyroid cancer, and one adenoma. Membrane staining was found in 2 samples of PTC (6.9%). Six samples (adenoma 1 sample, PTC 5 samples) showed NIS expression at membrane very weak (1+); they were considered as negative. NIS protein has several bands of ~ 80 kDa, ~ 62 kDa, and ~ 49 kDa. CONCLUSION: NIS expression in thyroid cancer mostly expresses in the cytoplasm instead of the membrane. NIS will play a functional role in the membrane to bring iodine across the membrane against the concentration. It can be the main reason for the lack of response of radioiodine in some differentiated thyroid cancers. © 2021 Aisyah Elliyanti, Rony Rustam, Tofrizal Tofrizal, Yenita Yenita, Susanto YDB. |
Follicular thyroid cancer; Immunohistochemistry; Membrane staining; Papillary thyroid cancer; Western blot |
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Open Access Macedonian Journal of Medical Sciences |
18579655 |
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Article |
Q3 |
288 |
15252 |
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891 |
Soetisna T.W., Buana A.C., Tirta E.S., Ardiyan A., Aligheri D., Herlambang B., Tjubandi A., Hanafy D.A., Sugisman S. |
57214887740;57221743134;57221753958;57212102199;57221752393;36468390900;57211055979;57220157579;57221747222; |
A 48-year-old man at low risk for SARS-CoV-2 infection who underwent planned elective triple-vessel coronary artery bypass graft surgery at a national heart center in indonesia followed by a fatal case of COVID-19 |
2021 |
American Journal of Case Reports |
22 |
1 |
e928900 |
1 |
5 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100047943&doi=10.12659%2fAJCR.928900&partnerID=40&md5=a033f16e0dbe64b1b4c3e7d6f2d25ab7 |
Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Department of Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Surgery, Faculty of Medicine, University Syiah Kuala, Banda Aceh, Indonesia; Department of Surgery, Faculty of Medicine, University Krida Wacana, Jakarta, Indonesia; Department of Anesthesiologist and Intensive Therapy, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Department of Anesthesiologist and Intensive Therapy, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Soetisna, T.W., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Buana, A.C., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Surgery, Faculty of Medicine, University Syiah Kuala, Banda Aceh, Indonesia; Tirta, E.S., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Surgery, Faculty of Medicine, University Krida Wacana, Jakarta, Indonesia; Ardiyan, A., Department of Anesthesiologist and Intensive Therapy, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Anesthesiologist and Intensive Therapy, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Aligheri, D., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Herlambang, B., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Tjubandi, A., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Hanafy, D.A., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Sugisman, S., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Patient: Male, 48-year-old Final Diagnosis: Chronic kidney disease • coronary artery disease • COVID-19 Symptoms: Chest pain • fever • shorthness of breath Medication: — Clinical Procedure: Coronary artery bypass graft surgery Specialty: Cardiac surgery Objective: Background: Case Report: Conclusions: Rare co-existance of disease or pathology This is of the first fatal case of coronavirus disease 2019 (COVID-19) pneumonia at a National Heart Center in Indonesia following planned elective triple-vessel coronary artery bypass graft (CABG) who was considered to be at low risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection when admitted for surgery. A 48-year-old man was diagnosed with coronary artery disease (CAD) in 3 vessels (3VD) with an ejection fraction (EF) of 61% and chronic kidney disease (CKD) with routine hemodialysis. The patient was scheduled for a coronary artery bypass graft (CABG) surgery. He underwent surgery after COVID-19 screening using a checklist provided by the hospital. The patient’s condition worsened on the 3rd postoperative day in the ward, and he was transferred back to the Intensive Care Unit (ICU), reintubated, and tested for COVID-19 with a real time-polymerase chain reaction (PCR) test. Because of the COVID-19 pandemic, we excluded the other possible pneumonia causes (e.g., influenza). An RT-PCR test performed after surgery revealed that the patient was positive for COVID-19. COVID-19 tracing was performed for all health care providers and relatives; all results were negative except for 1 family member. The patient was treated for 4 days in the isolation ICU but died due to complications of the infection. This report shows the importance of testing patients for SARS-CoV-2 infection before hospital admission for elective surgery and during the hospital stay, and the importance of developing rapid and accurate testing methods that can be used in countries and centers with limited health resources. © Am J Case Rep, 2021;. |
Coronary artery bypass; Coronary artery disease; COVID-19 |
bicarbonate; carbon dioxide; creatine kinase MB; creatinine; oxygen; urea; adult; anemia; angina pectoris; Article; bicarbonate blood level; blood carbon dioxide tension; blood oxygen tension; body mass; cardiomegaly; case report; cerebrovascular accident; chronic kidney failure; clinical article; comorbidity; contact examination; continuous renal replacement therapy; coronary angiography; coronary artery bypass graft; coronary artery disease; coronavirus disease 2019; creatine kinase blood level; creatinine blood level; deterioration; disease exacerbation; dyslipidemia; dyspnea; elective surgery; emergency surgery; emergency ward; fatality; fever; health care personnel; heart center; heart ejection fraction; hemodialysis; high risk patient; hospital admission; human; Indonesia; infection |
International Scientific Information, Inc. |
19415923 |
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33487629 |
Article |
Q3 |
247 |
16822 |
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894 |
Sandhiutami N.M.D., Arozal W., Louisa M., Rahmat D. |
56692904000;32067462200;41461551400;36673726800; |
Determine Curcumin Concentration in Organ Rats and in Ovaries at Ovarian Cancer Model Rats Using Ultra Performance Liquid Chromatography-Mass Spectrometry (Ms)/Ms |
2021 |
Pharmaceutical Sciences Asia |
48 |
1 |
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37 |
45 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099915596&doi=10.29090%2fPSA.2021.02.19.146&partnerID=40&md5=59970a9906f368c7cd760cdd0765143e |
Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Sandhiutami, N.M.D., Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia; Arozal, W., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahmat, D., Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia |
Curcumin has several pharmacological effects including anti-inflammatory, reduce kidney damage, hepatoprotector, and inhibiting tumor growth in ovarian cancer. The use of curcumin is limited because it has low bioavailability and low capacity to reach target organs. This limitation is overcome by making it in the form of nanoparticles. This study aim to determine curcumin levels on some organ in healthy rat groups and on ovaries at ovarian cancer models rat that given curcumin and curcumin nanoparticles. Measurement of curcumin levels using UPLC-MS/MS. Determination of curcumin level in the organ was carried out in 2 treatment groups, group that received curcumin and group that received curcumin nanoparticles orally with a single dose of 100 mg/kg Body Weight (BW). At 180 minutes, rats were decapitated for liver, kidney and ovaries. The ovarian cancer rats were also divided into 2 groups and given curcumin and curcumin nanoparticles with repeated doses of 100 mg/kgBW/day and after 30 days, ovarian cancer rats were decapitated for the ovaries. In the group that received curcumin, the concentration of curcumin in the liver, kidney and ovaries were less than the detection limit, whereas in the group that received curcumin nanoparticles, the levels of curcumin are 1,866.6±22.60 ng/g in liver, 114.87±13.36 ng/g in kidney and 136.864±11.15 ng/g in ovaries. In ovarian cancer rats, levels of curcumin in the group receiving curcumin is 2.29±1.15 ng/g and 17.76±4.85 ng/g in the group receiving curcumin nanoparticles. Curcumin nanoparticles can increase the distribution of curcumin in liver, kidney, ovaries in healthy rats and in ovaries at ovarian cancer model rats. © 2020. All Rights Reserved. |
curcumin; curcumin nanoparticles; ovarian cancer rats; rats organ; UPLC MS/MS |
curcumin; nanoparticle; animal experiment; animal model; animal tissue; Article; cancer model; controlled study; drug determination; drug distribution; drug liver level; female; kidney homogenate; limit of detection; limit of quantitation; liquid chromatography-mass spectrometry; liver homogenate; measurement accuracy; measurement precision; nonhuman; ovary; ovary cancer; rat; repeated drug dose; single drug dose |
Mahidol University - Faculty of Pharmacy |
25868195 |
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Article |
Q3 |
144 |
23834 |
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895 |
Tarigan T.J.E., Dwijayanti A., Setyowati S., Louisa M. |
36057746500;55743787900;54893136300;41461551400; |
Immunogenicity and efficacy of insulin glargine biosimilar ezelin versus originator insulin glargine in patients with type 2 diabetes |
2021 |
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy |
14 |
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107 |
116 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099828801&doi=10.2147%2fDMSO.S279385&partnerID=40&md5=4adefbb901a3483328866d6334ab8e3d |
Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Endocrinology, Department of Internal Medicine, Gatot Soebroto Presidential Hospital, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Tarigan, T.J.E., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Dwijayanti, A., Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setyowati, S., Division of Endocrinology, Department of Internal Medicine, Gatot Soebroto Presidential Hospital, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Purpose: To compare the immunogenicity and efficacy of insulin glargine biosimilar Ezelin (EZL) versus originator insulin glargine Lantus (LAN) as a reference basal insulin in patients with type 2 diabetes (T2D). Patients and Methods: This was a randomized, multicenter, open-label, 24-week study in insulin-naïve patients with T2D, with HbA1c of >7.0%. We randomly assigned 133 eligible patients to receive either EZL or LAN. Baseline characteristics, including insulin autoantibody (IAA), zinc transporter 8 (ZnT8) antibody, HbA1C, fasting plasma glucose (FPG), 2-hour postprandial plasma glucose (2hPPG), AST, ALT, BUN, eGFR, and oral antidiabetic drugs, were obtained before starting insulin treatment. After starting treatment, insulin dose was titrated to achieve FPG target along with oral antidiabetic drugs. Patients were given home glucometer and assisted to record plasma glucose measurement and adverse event (AE). Every month, patients came to the diabetes clinic and performed a regular physical examination and intensifying treatment if needed. Out of the 133 randomized patients, only 122 completed the study and can be examined for their IAA and ZnT8 after 6 months of treatment. The study was registered in clinicaltrials.gov, NCT03352674. Results: There is a similar proportion of patients with changes of IAA from baseline: 1 out of 58 (1.7%) patients receiving EZL versus 1 out of 64 (1.6%) patients receiving LAN (p = 1.000). One patient in the EZL group (1.7%) versus none in the LAN group experienced a change of ZnT8 antibody from baseline. Similar glucose control in EZL versus LAN was determined by the change in HbA1c, FPG, and 2hPPG (−2.0%, −67.46 mg/dL, and −76.51 mg/dL in the EZL group versus −1.7%, −58.11 mg/dL, and −70.03 mg/dL in the LAN group). There were six events of documented hypoglycemia in the EZL group versus five events in the LAN group. No patients experienced diabetic ketoacidosis during the study. Conclusion: Overall, insulin glargine biosimilar EZL and originator insulin glargine LAN have shown a similar immunogenicity profile, as well as efficacy in providing glucose control and safety findings in T2D populations. © 2021 Tarigan et al. |
Biosimilar; Hyperglycemia; Insulin autoantibody; Zinc transporter 8 antibody |
acarbose; alanine aminotransferase; aspartate aminotransferase; ezelin; glucose; hemoglobin A1c; insulin antibody; insulin glargine; metformin; pioglitazone; protein antibody; sulfonylurea; unclassified drug; urea; zinc transporter 8; zinc transporter 8 antibody; acute gastroenteritis; acute kidney failure; adult; alanine aminotransferase blood level; Article; aspartate aminotransferase blood level; Bell palsy; cardiovascular disease; cerebrovascular accident; cervical spine fracture; controlled study; coughing; dermatitis; diabetic ketoacidosis; diabetic patient; diabetic ulcer; diarrhea; drug dose titration; drug efficacy; drug safety; dyspepsia; dyspnea; estimated glomerular filtration rate; fasting; female; gangrene; gastritis; gastroesophageal reflux; gastrointestinal symptom; glucose |
Dove Medical Press Ltd |
11787007 |
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Article |
Q2 |
853 |
5525 |
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899 |
Tanto I.V., Dharma S., Juzar D.A., Bono A.A.H. |
57221612652;55101301700;55358712500;57208146721; |
Ventricular Septal Rupture Complicating an Acute ST-Segment Elevation Myocardial Infarction during the COVID-19 Pandemic |
2021 |
International Journal of Angiology |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099596441&doi=10.1055%2fs-0040-1720971&partnerID=40&md5=aab866db219c647750534315d55f3fdf |
Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jl S Parman Kav 87, Slipi, Jakarta Barat, Jakarta, 11420, Indonesia; Division of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
Tanto, I.V., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jl S Parman Kav 87, Slipi, Jakarta Barat, Jakarta, 11420, Indonesia; Dharma, S., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jl S Parman Kav 87, Slipi, Jakarta Barat, Jakarta, 11420, Indonesia; Juzar, D.A., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jl S Parman Kav 87, Slipi, Jakarta Barat, Jakarta, 11420, Indonesia; Bono, A.A.H., Division of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
Ventricular septal rupture (VSR) is rare but a lethal complication of acute myocardial infarction (MI). Definite treatment requires the surgical closure of the VSR and coronary artery bypass grafting (CABG). However, the optimal timing for surgery is still controversial, particularly during the novel coronavirus disease 2019 (COVID-19) pandemic where medical procedures should be performed within the safest environment. Before surgery, a proper management in the intensive cardiovascular care unit is essential to maintain the stability of the hemodynamic profile related with VSR and determines the prognosis of the patient. We described a case of VSR complicating an anterior wall MI in a patient who admitted to our hospital during the COVID-19 pandemic that was treated successfully by surgical closure of the VSR and CABG. © 2021 BMJ Publishing Group. All rights reserved. |
bypass grafting; myocardial infarction; surgical repair; ventricular septal rupture |
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Thieme Medical Publishers, Inc. |
10611711 |
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Article |
Q3 |
293 |
15070 |
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902 |
Bahtiar A., Miranda A.J., Arsianti A. |
35365874400;57221531432;36124567000; |
The effect of artocarpus altilis (parkinson) fosberg extract supplementation on kidney ischemia-reperfusion injury rat |
2021 |
Pharmacognosy Journal |
13 |
1 |
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150 |
154 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099365078&doi=10.5530%2fpj.2021.13.21&partnerID=40&md5=13b866767b1597a22566e8ac646a0b9f |
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Department of Medicinal Chemistry, Faculty of Medicine, Universitas Indonesia, Kampus UI Salemba, Jakarta, Indonesia |
Bahtiar, A., Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Miranda, A.J., Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Arsianti, A., Department of Medicinal Chemistry, Faculty of Medicine, Universitas Indonesia, Kampus UI Salemba, Jakarta, Indonesia |
Background: Acute kidney injury (AKI) is a kidney disease resulting in high morbidity and mortality levels in humans. One of the disorders classified as AKI is ischemia-reperfusion injury (IRI), characterized by two phases. The first phase is Ischemia in the kidneys due to obstruction of the renal arteries or veins, followed by the second phase, which is the occurrence of reperfusion with blood flowing back in the renal arteries veins. The aim of this current research is to analyze the efficacy of Artocarpus altilis on Kidney ischemia-reperfusion model rats. Methods: To this end, first, we established Ischaemia-reperfusion kidney injury rat. We then evaluated the Artocarpus altilis extract on IRI model rats. A total of 36 rats have grouped into six groups. Group I is the Sham group, Group II is the negative control group, Group III is the positive control group (vitamin C 100 mg/kg BW), Group IV is Dose I of Artocarpus altilis extract 50 mg/kg BW), Group V is Dose II Artocarpus altilis extract 100 mg/kg BW), Group VI is Dose III Artocarpus altilis extract 200 mg/kg BW). The vitamin C and Artocarpus altilis extract administered 14 days before and after Ischemia-reperfusion treatment. At day 0, Ischemia was made by bilateral renal pedicle clamping method for 30 minutes, sacrificed 14 days after reperfusion. The blood and histology samples were collected on day 0, a day after reperfusion, at 24 hrs after reperfusion, at 48 hrs after reperfusion, and 14 days after treatment. Results: The clamping duration of 30 minutes leads to achieving the most representative clinical IRI conditions. It shows the most significant recovery of injury conditions within the 14-day reperfusion period in IRI animal models, making it ideal for IRI operations for the preliminary test. The administration of 100 mg/kg BW of Artocarpus altilis extract could reduce the malondialdehyde plasma compared with the sham group. The SOD and Catalase activity showed improvement after reperfusion. Conclusion: Artocarpus altilis extracts showed antioxidant activity to prevent the kidney from ischemia-reperfusion injury by modulated SOD and Catalase. © 2021 Phcogj.Com. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license. |
Acute kidney disease; Artocarpus altilis (Parkinson) Fosberg; Free radicals; Reperfusion injury; Sukun |
antiinflammatory agent; antioxidant; Artocarpus altilis extract; ascorbic acid; catalase; creatinine; malonaldehyde; nitrogen; plant extract; protective agent; superoxide dismutase; unclassified drug; urea; animal experiment; animal model; animal tissue; antiinflammatory activity; antioxidant activity; Article; blood sampling; controlled study; creatinine blood level; dose response; drug efficacy; enzyme activity; enzyme blood level; glomerulus filtration rate; histopathology; male; nonhuman; rat; renal ischemia reperfusion injury; renal protection; supplementation; treatment duration; urea nitrogen blood level |
EManuscript Technologies |
09753575 |
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Article |
Q3 |
268 |
15961 |
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904 |
Widaty S., Soebono H., Sunarto, Emilia O. |
57208261546;6508242918;57221528270;6504322013; |
Development of a new instrument to assess clinical performance of residents in dermatology-Venereology department |
2021 |
Asia Pacific Scholar |
6 |
1 |
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70 |
82 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099335332&doi=10.29060%2fTAPS.2021-6-1%2fOA2241&partnerID=40&md5=7ccb3f67cc4a32f511df79fd292001b5 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Indonesia; Department of Dermatology and Venereology Faculty of Medicine, Universitas Gadjah Mada, Indonesia; Pediatric Department, Faculty of Medicine, Universitas Gadjah Mada Indonesia, Indonesia; Medical Education Department, Faculty of Medicine, Universitas Gadjah Mada, Indonesia |
Widaty, S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Indonesia; Soebono, H., Department of Dermatology and Venereology Faculty of Medicine, Universitas Gadjah Mada, Indonesia; Sunarto, Pediatric Department, Faculty of Medicine, Universitas Gadjah Mada Indonesia, Indonesia; Emilia, O., Medical Education Department, Faculty of Medicine, Universitas Gadjah Mada, Indonesia |
Introduction: Performance assessment of residents should be achieved with evaluation procedures, informed by measured and current educational standards. The present study aimed to develop, test, and evaluate a psychometric instrument for evaluating clinical practice performance among Dermatology and Venereology (DV) residents. Methods: This is a qualitative and quantitative study conducted from 2014 to 2016. A pilot instrument was developed by 10 expert examiners from five universities to rate four video-recorded clinical performance, previously evaluated as good and bad performance. The next step was the application of the instrument to evaluate the residents which was carried out by the faculty of DV at two Universities. Results: The instrument comprised 11 components. There was a statistically significant difference (p < 0.001) between good and bad performance. Cronbach’s alpha documented high overall reliability (α = 0.96) and good internal consistency (α = 0.90) for each component. The new instrument correctly evaluated 95.0% of poor performance. The implementation study showed that inter-rater reliability between evaluators range from low to high (correlation coefficient α =0.79, p < 0.001). Conclusion: The instrument is a reliable and valid instrument for assessing clinical practice performance of DV residents. More studies are required to evaluate the instrument in different situation. © 2021 TAPS. All rights reserved. |
Clinical Assessment; Dermatology-Venereology; Instrument; Performance; Resident; Workplace-Based Assessment |
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National University of Singapore, Faculty of Law |
24249335 |
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Article |
#N/A |
#N/A |
#N/A |
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905 |
Aniwidyaningsih W., Elhidsi M., Sari A., Burhan E. |
25421525900;57203157152;57221412037;36058554600; |
Characteristics and outcomes of endobronchial tuberculosis therapy |
2021 |
Lung India |
38 |
1 |
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101 |
103 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099112158&doi=10.4103%2flungindia.lungindia-132-20&partnerID=40&md5=5591017e20ced501e613a0e37ddc0328 |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia |
Aniwidyaningsih, W., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Elhidsi, M., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Sari, A., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Burhan, E., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia |
[No abstract available] |
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ethambutol; isoniazid; pyrazinamide; rifampicin; steroid; adult; airway obstruction; balloon dilatation; bronchoscopy; clinical article; computer assisted tomography; endobronchial tuberculosis; female; human; Letter; lung tuberculosis; main bronchus; male; retrospective study; thorax radiography; treatment response |
Wolters Kluwer Medknow Publications |
09702113 |
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Letter |
Q3 |
457 |
10877 |
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