No records
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84 |
Makmun D., Simadibrata M., Abdullah M., Syam A.F., Shatri H., Fauzi A., Renaldi K., Maulahela H., Utari A.P., Pribadi R.R., Muzellina V.N., Nursyirwan S.A. |
16638046900;23499598400;7103393434;8443384400;28767986500;36518523000;57190963547;57189612709;57113585900;57194732282;57223968527;57249143800; |
Retrospective Study Colorectal cancer patients in a tertiary hospital in Indonesia: Prevalence of the younger population and associated factors |
2021 |
World Journal of Clinical Cases |
9 |
32 |
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9804 |
9814 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119652838&doi=10.12998%2fwjcc.v9.i32.9804&partnerID=40&md5=75cf4743775cd03169188a4206cb7cb0 |
Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Clinical Epidemiology Unit, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia |
Makmun, D., Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Simadibrata, M., Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Abdullah, M., Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Syam, A.F., Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Shatri, H., Clinical Epidemiology Unit, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Fauzi, A., Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Renaldi, K., Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Maulahela, H., Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Utari, A.P., Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Pribadi, R.R., Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Muzellina, V.N., Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia; Nursyirwan, S.A., Division of Gastroenterology, Pancreatobiliary & Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesiao, Cipto Mangunkusumo National General Hospital, Jakarta, 10430, Indonesia |
BACKGROUND An increasing trend in colorectal cancer (CRC) occurring at younger ages has been observed worldwide, even though incidence is declining in the general population. Most currently available guidelines still recommend CRC screening for older populations, despite an alarming rise in early-onset CRC incidence. Risk stratification is necessary to further determine the population most at risk for early-onset CRC. However, epidemiological data on related clinical characteristics and potential risk factors, especially in developing countries, have not been widely reported. AIM To investigate the prevalence, demographics, clinicopathologic features, and associated factors of young-onset CRC patients in a tertiary hospital in Indonesia. METHODS Patients undergoing colonoscopy examination between 2008 and 2019, yielding a diagnosis of CRC were identified from medical records. The subjects were classified into two groups according to their age at diagnosis, namely early-onset (18–49 years old) and late-onset (≥ 50-years-old). Demographic data, characteristics, and risk factors of both onset age groups were evaluated using the chisquare and Fisher’s exact test. RESULTS Among 495 CRC patients confirmed by histopathology, 205 (41.4%) were classified as early-onset and 290 (58.6%) as late-onset. Most subjects in the early-onset CRC group were male (53.7%), with 89.8% displaying adenocarcinoma histopathology. A majority (78%) of the early-onset CRC patients had left-sided tumors, with the rectum (41%) and rectosigmoid (17.6%) being the most common sites. Abdominal pain was the most frequent symptom in the early-onset CRC patients (55.6%), which was significantly higher than that in the late-onset CRC patients (43.8%, P > 0.05). Early-onset CRC cases were more likely to be underweight (34.6% vs 20.0%, P < 0.001) compared to late-onset CRC cases. The proportion of subjects with suspected hereditary nonpolyposis colorectal cancer (HNPCC) was also higher in the early-onset CRC group than in the late-onset age group (9.3% vs 4.1%, P < 0.05). However, no difference was observed in the parental or family histories of CRC cases. CONCLUSION Early-onset CRC patients were more likely to have abdominal pain, underweight status, and HNPCC suspicion than late-onset CRC patients. © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
Associated factors; Colorectal cancer; Early onset; Epidemiology; Indonesia; Tertiary hospital |
abdominal pain; adenocarcinoma; adult; aged; Article; body mass; carcinoid; colon; colonoscopy; colorectal cancer; cross-sectional study; diabetes mellitus; familial adenomatous polyposis; female; hereditary nonpolyposis colorectal cancer; histopathology; human; human tissue; hypertension; major clinical study; male; medical record; obesity; prevalence; rectum; rectum hemorrhage; retrospective study; risk factor; smoking; underweight; very elderly |
Baishideng Publishing Group Co |
23078960 |
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Article |
Q3 |
368 |
12908 |
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No records
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336 |
Hidayat R., Diafiri D., Zairinal R.A., Arifin G.R., Azzahroh F., Widjaya N., Fani D.N., Mesiano T., Kurniawan M., Rasyid A., Giantini A., Haris S. |
57225289998;57369144600;57214092762;57221703744;57219418635;57424739100;57424721100;57204830976;57196001182;56703146700;12776781400;57222343545; |
Acute Ischaemic Stroke Incidence after Coronavirus Vaccine in Indone-sia: Case Series |
2021 |
Current Neurovascular Research |
18 |
3 |
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360 |
363 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123387853&doi=10.2174%2f1567202618666210927095613&partnerID=40&md5=56196ab18737f980961c6a27a7823638 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Universitas Indonesia Hospital, Universitas Indone-sia, Depok, Indonesia |
Hidayat, R., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Universitas Indonesia Hospital, Universitas Indone-sia, Depok, Indonesia; Diafiri, D., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Universitas Indonesia Hospital, Universitas Indone-sia, Depok, Indonesia; Zairinal, R.A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Universitas Indonesia Hospital, Universitas Indone-sia, Depok, Indonesia; Arifin, G.R., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Azzahroh, F., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Widjaya, N., Universitas Indonesia Hospital, Universitas Indone-sia, Depok, Indonesia; Fani, D.N., Universitas Indonesia Hospital, Universitas Indone-sia, Depok, Indonesia; Mesiano, T., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kurniawan, M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rasyid, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Giantini, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Universitas Indonesia Hospital, Universitas Indone-sia, Depok, Indonesia; Haris, S., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Coronavirus disease-19 (COVID-19) is an infectious disease with high morbidity and mortality rates. Indonesia had reported a 2.8% of mortality rate up to June 2021. Case Presentation: A strategy to control the virus spreading is by vaccination. The Indonesian Food and Drug Monitoring Agency had approved the use of CoronaVac, an inactivated virus vaccine developed by Sinovac. Most Adverse Events Following Immunization (AEFI) for Corona-Vac are mild, and the most common symptoms are injection-site pain, headache, and fatigue. Neu-rovascular adverse events, including thrombosis or ischaemic stroke after receiving CoronaVac have not previously been reported. Conclusion: Correspondingly, we reported three patients with an Acute Ischaemic Stroke (AIS) after the administration of CoronaVac in our hospital. © 2021 Bentham Science Publishers. |
AEFI; CoronaVac; COVID 19; COVID-19; Stroke; Vaccine |
inactivated vaccine; adverse event; aged; brain ischemia; case report; human; incidence; Indonesia; male; middle aged; prevention and control; Aged; COVID-19; COVID-19 Vaccines; Humans; Incidence; Indonesia; Ischemic Stroke; Male; Middle Aged; SARS-CoV-2; Vaccines, Inactivated |
Bentham Science Publishers |
15672026 |
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34579636 |
Article |
Q3 |
592 |
8538 |
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640 |
Yulia D.E., Pambudy I.M., Amanda L. |
57225947931;57327482000;57225929959; |
Review of Corticosteroid Use in Pediatric Cataract Surgery |
2021 |
Open Ophthalmology Journal |
15 |
1 |
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251 |
257 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122381840&doi=10.2174%2f1874364102115010251&partnerID=40&md5=443070a1878e6bcf97e1132e3d5f8357 |
Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Yulia, D.E., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Pambudy, I.M., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Amanda, L., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: Following pediatric cataract surgery, an intense inflammatory response is related to various complications, including posterior capsule opacification (PCO), which is a visually threatening incidence that can lead to visual axis opacification (VAO). Although corticosteroids are essentially effective in reducing inflammation, potential ocular side effects are a remaining concern. Objective: This study aimed to review the efficacy and safety of corticosteroid drugs and their administration routes in pediatric patients who underwent cataract surgery Methods: A literature search was conducted from four electronic databases using keywords selected a priori. Identified articles were sorted according to the type of corticosteroid used, route of administration, and outcome measures, including inflammatory response and ocular side effects. Results: Five studies were included with one case series, one retrospective case-control, and three clinical trials. The total number of subjects was 311 patients, with an age range of six weeks to 15 years old. Four studies analyzed the use of triamcinolone acetonide intracamerally, which was superior to topical steroids. Most of the studies reported a decrease in inflammatory parameters. The outcome of PCO and VAO varied between studies. Nearly all the studies observed elevated intraocular pressure (IOP) as an ocular side effect. Conclusion: Various corticosteroids and different delivery routes can be used to ameliorate inflammation in pediatric cataract surgery. However, there is promising evidence suggesting intracameral steroids as substantially beneficial in reducing inflammatory parameters. Due to the limited number of studies reviewed, no firm conclusion regarding the superior steroid preparation or route of administration can be inferred. This review highlights the need for further studies. © 2021 Yulia et al. |
Corticosteroid; Drug administration; Inflammation; Ocular side effect; Pediatric cataract surgery; Posterior capsular opacification |
corticosteroid; cataract; cataract extraction; drug administration route; drug safety; human; inflammation; intraocular pressure; outcome assessment; pediatric patient; pediatric surgery; Review; side effect; topical drug administration |
Bentham Science Publishers |
18743641 |
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Review |
Q2 |
670 |
7468 |
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763 |
Gunardi W.D., Timotius K.H., Natasha A., Evriarti P.R. |
57222314683;24299781600;57211428938;57226004232; |
Biofilm targeting strategy in the eradication of burkholderia infections: A mini-review |
2021 |
Open Microbiology Journal |
15 |
1 |
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51 |
57 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110074931&doi=10.2174%2f1874285802115010051&partnerID=40&md5=70632c812ea82598129daf4afdd465df |
Department of Microbiology, Faculty of Medicine, Krida Wacana Christian University (UKRIDA), Jakarta, Indonesia; Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Microbiolgy, Health Labortory of Makassar (BBLK Makassar), Makassar, Indonesia |
Gunardi, W.D., Department of Microbiology, Faculty of Medicine, Krida Wacana Christian University (UKRIDA), Jakarta, Indonesia; Timotius, K.H., Department of Microbiology, Faculty of Medicine, Krida Wacana Christian University (UKRIDA), Jakarta, Indonesia; Natasha, A., Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Evriarti, P.R., Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Microbiolgy, Health Labortory of Makassar (BBLK Makassar), Makassar, Indonesia |
Burkholderia are intracellular pathogenic bacteria which can produce biofilm. This biofilm protects the intracellular pathogenic bacteria from antibiotic treatment and the immunological system of the host. Therefore, this review aims to describe the capacity of Burkholderia to form a biofilm, the regulation of its biofilm formation, the efficacy of antibiotics to eradicate biofilm, and the novel therapy which targets its biofilm. Burkholderia's biofilm is characterized by its lipopolysaccharides, exopolysaccharides (EPSs), biofilm-associated proteins, and eDNA. Its regulation is made by quorum sensing, c-di-AMP, sRNA, and two component systems. Many antibiotics have been used as sole or mixture agents; however, they are not always effective in eradicating the biofilm-forming Burkholderia. Inhibitors of quorum sensing and other non-conventional antibiotic approaches are promising to discover effective treatment of Burkholderia infections. © 2021, Bentham Science Publishers. All rights reserved. |
Antibiotic; Biofilm; Burkholderia; Exopolysaccharide; Lipid A; Quorum sensing |
acetazolamide; amoxicillin; antibiotic agent; cefepime; ceftazidime; colistin; echinocandin; exopolysaccharide; gentamicin; imipenem; indisulam; lipopolysaccharide; macrolide; meropenem; piperacillin plus tazobactam; polymyxin B; RANTES; saccharin; sulpiride; tobramycin; topiramate; transcriptome; vancomycin; virulence factor; Acinetobacter baumannii; antibiofilm activity; antibiotic resistance; antibiotic sensitivity; antibiotic therapy; apoptosis; Article; autolysis; bacteremia; bacterial arthritis; bacterial colonization; bacterial gene; bacterial growth; bacterial virulence; Betaproteobacteria; biofilm; Burkholderia cenocepacia; Burkholderia infection; Burkholderia pseudomallei; cell aggregation; DNA damage; Enterococcus faecalis; extracellular matrix; gene; gene expression; Helicobact |
Bentham Science Publishers |
18742858 |
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Article |
Q3 |
502 |
10043 |
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No records
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39 |
Marofi F., Kozlitina I.A., Margiana R., Bahramali M., Suksatan W., Abdelbasset W.K., Chupradit S., Nasimi M., Maashi M.S. |
57199650994;57428645300;56685900600;57365531600;57219950613;57208873763;57211329338;57189347372;57220613490; |
MSCs and their exosomes: a rapidly evolving approach in the context of cutaneous wounds therapy |
2021 |
Stem Cell Research and Therapy |
12 |
1 |
597 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120732728&doi=10.1186%2fs13287-021-02662-6&partnerID=40&md5=1bb65103a59b38f350d6be8213b4dad8 |
Immunology Research Center (IRC), Tabriz University of Medical Sciences, Tabriz, Iran; Sechenov First Moscow State Medical University, Moscow, Russian Federation; Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Master’s Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Biotechnology Department, University of Tehran, Tehran, Iran; Faculty of Nursing, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, 10210, Thailand; Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia; Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt; Department of Occupational Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, 50200, Thailand; Tehran University of Medical Sciences, Tehran, Iran; Stem Cells and Regenerative Medicine Unit at King Fahad Medical Research Centre, Jeddah, Saudi Arabia |
Marofi, F., Immunology Research Center (IRC), Tabriz University of Medical Sciences, Tabriz, Iran; Kozlitina, I.A., Sechenov First Moscow State Medical University, Moscow, Russian Federation; Margiana, R., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Master’s Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Bahramali, M., Biotechnology Department, University of Tehran, Tehran, Iran; Suksatan, W., Faculty of Nursing, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, 10210, Thailand; Abdelbasset, W.K., Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia, Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt; Chupradit, S., Department of Occupational Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, 50200, Thailand; Nasimi, M., Tehran University of Medical Sciences, Tehran, Iran; Maashi, M.S., Stem Cells and Regenerative Medicine Unit at King Fahad Medical Research Centre, Jeddah, Saudi Arabia |
Currently, mesenchymal stem/stromal stem cell (MSC) therapy has become a promising option for accelerating cutaneous wound healing. In vivo reports have outlined the robust competences of MSCs to offer a solid milieu by inhibition of inflammatory reactions, which in turn, enables skin regeneration. Further, due to their great potential to stimulate angiogenesis and also facilitate matrix remodeling, MSCs hold substantial potential as future therapeutic strategies in this context. The MSCs-induced wound healing is thought to mainly rely on the secretion of a myriad of paracrine factors in addition to their direct differentiation to skin-resident cells. Besides, MSCs-derived exosomes as nanoscale and closed membrane vesicles have recently been suggested as an effective and cell-free approach to support skin regeneration, circumventing the concerns respecting direct application of MSCs. The MSCs-derived exosomes comprise molecular components including lipid, proteins, DNA, microRNA, and also mRNA, which target molecular pathways and also biological activities in recipient cells (e.g., endothelial cell, keratinocyte, and fibroblast). The secreted exosome modifies macrophage activation, stimulates angiogenesis, and instigates keratinocytes and dermal fibroblast proliferations as well as migrations concurrently regulate inherent potential of myofibroblast for adjustment of turnover of the ECM. In the present review, we will focus on the recent findings concerning the application of MSCs and their derivative exosome to support wound healing and skin regeneration, with special focus on last decade in vivo reports. © 2021, The Author(s). |
Cutaneous wounds; Differentiation; Exosome; Mesenchymal stem/stromal stem cell (MSC); Paracrine factors |
angiopoietin 1; angiopoietin 2; biomaterial; chemokine receptor CCR2; chemokine receptor CCR3; chemokine receptor CXCR1; chemokine receptor CXCR4; collagen type 1; collagen type 3; elastin; fibroblast growth factor 2; gelatinase B; immunoglobulin enhancer binding protein; interleukin 1; interleukin 6; microRNA; microRNA 21 5p; mitogen activated protein kinase; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; platelet derived growth factor beta receptor; platelet endothelial cell adhesion molecule 1; stromal cell derived factor 1; toll like receptor 4; tumor necrosis factor; unclassified drug; vasculotropin; vasculotropin C; angiogenesis; biogenesis; cell differentiation; cell migration; cell proliferation; diabetic foot; endothelium cell; exosome; extracellular matrix; fibroblast; h |
BioMed Central Ltd |
17576512 |
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34863308 |
Review |
Q1 |
1599 |
2021 |
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47 |
Craddock N., Garbett K.M., Haywood S., Nasution K., White P., Saraswati L.A., Rizkiah C., Medise B.E., Diedrichs P.C. |
57204036842;56901034200;57339654700;57339654800;55730025700;55842541900;57339370700;57194679894;6504448191; |
‘Dove Confident Me Indonesia: Single Session’: study protocol for a randomised controlled trial to evaluate a school-based body image intervention among Indonesian adolescents |
2021 |
BMC Public Health |
21 |
1 |
2102 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119148188&doi=10.1186%2fs12889-021-11770-0&partnerID=40&md5=081ebeb058ffd74b7c5312132c820642 |
Centre for Appearance Research, University of the West of England, Coldharbour Lane, Bristol, BS16 1QY, United Kingdom; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; University of Hawaiʻi at Mānoa, Honolulu, United States; Lazuardi Al Falah Depok Junior High School Indonesia, Kota Depok, Indonesia |
Craddock, N., Centre for Appearance Research, University of the West of England, Coldharbour Lane, Bristol, BS16 1QY, United Kingdom; Garbett, K.M., Centre for Appearance Research, University of the West of England, Coldharbour Lane, Bristol, BS16 1QY, United Kingdom; Haywood, S., Centre for Appearance Research, University of the West of England, Coldharbour Lane, Bristol, BS16 1QY, United Kingdom; Nasution, K., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; White, P., Centre for Appearance Research, University of the West of England, Coldharbour Lane, Bristol, BS16 1QY, United Kingdom; Saraswati, L.A., University of Hawaiʻi at Mānoa, Honolulu, United States; Rizkiah, C., Lazuardi Al Falah Depok Junior High School Indonesia, Kota Depok, Indonesia; Medise, B.E., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Diedrichs, P.C., Centre for Appearance Research, University of the West of England, Coldharbour Lane, Bristol, BS16 1QY, United Kingdom |
Background: Due to the prevalence and associated adverse health consequences of negative body image among adolescents globally, there is a need to develop acceptable, effective, and scalable interventions. School-based body image interventions delivered by trained teachers show promise in reducing negative body image in adolescents. However, there is currently a lack of evidenced-based body image interventions for use in low- and middle-income countries (LMICs). This paper outlines a protocol for the development and evaluation of Dove Confident Me Indonesia: Single Session, a single-session, teacher-led body image intervention for Indonesian adolescents. Method: The effectiveness of the intervention will be evaluated using a cluster randomised controlled trial design. Due to the COVID-19 pandemic, the trial will be conducted online. Trained teachers or school guidance counsellors will deliver the intervention. Self-report questionnaires will be collected at three time points: baseline, post-intervention, and two-month follow-up. The primary outcome is body esteem. Secondary outcomes are internalisation of appearance ideals, mood, engagement in life activities, tendency to engage in appearance comparisons, and skin shade satisfaction. A minimum of 1000 participants will provide 95% power to detect small-to-medium intervention effects. To account for attrition and potential internet issues, the sample will comprise of 2000 Indonesian adolescents in grades 7–9, attending state junior high schools in Surabaya, East Java. Quantitative and qualitative data on acceptability of the intervention will also be collected from teachers and students. Additionally, fidelity of lesson implementation will be assessed. This project received ethical approval from the Universitas Indonesia and the University of the West of England. The intervention will be disseminated in junior high schools throughout Indonesia via UNICEF’s Life Skills Education (LSE) programme, which will be freely available for teachers to download. Discussion: This paper presents Dove Confident Me Indonesia: Single Session, a culturally adapted school-based intervention designed to improve Indonesian adolescents’ body image. It details the plan for evaluation, highlighting the strengths and limitations of the proposed study design. It will be informative for others aiming to adapt evidence-based school curricula to promote well-being among adolescents in LMICs. Trial registration: NCT04665557. Registered 11th December 2020. © 2021, The Author(s). |
Adolescent mental health; Body image; Indonesia; Life skills education; Low- and middle-income countries; Randomised controlled trial; School-based intervention; Single-session intervention; Southeast Asia; Study protocol |
adolescent; body image; human; Indonesia; pandemic; randomized controlled trial (topic); school; school health service; Adolescent; Body Image; COVID-19; Humans; Indonesia; Pandemics; Randomized Controlled Trials as Topic; SARS-CoV-2; School Health Services; Schools |
BioMed Central Ltd |
14712458 |
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34784916 |
Article |
Q1 |
1230 |
3166 |
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48 |
Wijaya I.P., Karim B., Azizi M.S., Ariyanto I., Mansjoer A., Yunihastuti E., Harimurti K., Alwi I., Lee S., Price P. |
57193731572;57192910797;57209578916;57193538110;24335647800;57221273925;23473513200;15055173800;56272877300;57201814264; |
Cytomegalovirus may influence vascular endothelial health in Indonesian HIV-infected patients after 5 years on ART |
2021 |
AIDS Research and Therapy |
18 |
1 |
83 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119002384&doi=10.1186%2fs12981-021-00410-7&partnerID=40&md5=9b7b4701ffbdd4086f464a8411ac8de3 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Virology and Cancer Pathobiology Research Centre, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; School of Medicine, Curtin University, Bentley, 6102, Australia |
Wijaya, I.P., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Karim, B., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Azizi, M.S., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ariyanto, I., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Virology and Cancer Pathobiology Research Centre, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mansjoer, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Yunihastuti, E., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Harimurti, K., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Alwi, I., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Lee, S., School of Medicine, Curtin University, Bentley, 6102, Australia; Price, P., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, School of Medicine, Curtin University, Bentley, 6102, Australia |
Objectives: Accelerated atherosclerosis in older HIV-infected patients has been attributed to persistent immune activation and high burden cytomegalovirus (CMV), as demonstrated in transplant recipients and the general population. Here we assess CMV and inflammatory markers linked with vascular health in young adult patients treated in Indonesia. Study design: HIV-infected adults (n = 32) were examined when they began antiretroviral therapy (ART) with < 200 CD4 T-cells/µl (V0) and after 60 months (V60). Age-matched healthy controls (HC, n = 32) were assessed once. Methods: Flow Mediated Dilatation (FMD) was assessed by ultrasound on brachial arteries at V60 and in HC. Plasma markers of immune activation and endothelial activation, and CMV antibodies (lysate, gB, IE-1) were assessed in all samples. Results were assessed using bivariate (non-parametric) and multivariable analyses. Results: Levels of inflammatory biomarkers and CMV antibodies declined on ART, but the antibodies remained higher than in HC. FMD values were similar in patients and HC at V60. In HIV patients, levels of CMV lysate antibody correlated inversely (r = − 0.37) with FMD. The optimal model predicting lower FMD values (adjusted R2 = 0.214, p = 0.012) included CMV lysate antibodies and chondroitin sulphate. In HC, levels of sTNFR correlated inversely with FMD (r = − 0.41) and remained as a risk factor in the optimal multivariable model, with CMV glycoprotein-B (gB) antibody predicting a healthier FMD (adjusted R2 = 0.248, p = 0.013). Conclusions: Higher levels CMV antibodies optimally predict vascular health measured by FMD in HIV patients. However in healthy controls, sTNFR marks risk and CMV gB antibody may be protective. © 2021, The Author(s). |
CMV; Endothelial function; HIV; Inflammatory biomarkers |
virus antibody; aged; Cytomegalovirus; cytomegalovirus infection; human; Human immunodeficiency virus infection; Indonesia; Aged; Antibodies, Viral; Cytomegalovirus; Cytomegalovirus Infections; HIV Infections; Humans; Indonesia |
BioMed Central Ltd |
17426405 |
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34763708 |
Article |
Q1 |
1102 |
3778 |
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49 |
Al-Jawadi A.A., Priliani L., Oktavianthi S., Febinia C.A., Daya M., Artika I.M., Malik S.G. |
57327931000;57203360168;38361976900;55195897900;57208032155;57194561825;7402973374; |
Association of FTO rs1421085 single nucleotide polymorphism with fat and fatty acid intake in Indonesian adults |
2021 |
BMC Research Notes |
14 |
1 |
411 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118749881&doi=10.1186%2fs13104-021-05823-1&partnerID=40&md5=c2e5f8f0c5b077d184062624f315d2dc |
Department of Biochemistry, Faculty of Mathematics and Natural Sciences, Bogor Agricultural University, Kampus IPB Dramaga, Jl. Raya Dramaga, Bogor, West Java 16680, Indonesia; Eijkman Institute for Molecular Biology, Ministry of Research and Technology/National Research and Innovation Agency, Jl. Diponegoro No. 69, Jakarta, 10430, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Al-Jawadi, A.A., Department of Biochemistry, Faculty of Mathematics and Natural Sciences, Bogor Agricultural University, Kampus IPB Dramaga, Jl. Raya Dramaga, Bogor, West Java 16680, Indonesia; Priliani, L., Eijkman Institute for Molecular Biology, Ministry of Research and Technology/National Research and Innovation Agency, Jl. Diponegoro No. 69, Jakarta, 10430, Indonesia; Oktavianthi, S., Eijkman Institute for Molecular Biology, Ministry of Research and Technology/National Research and Innovation Agency, Jl. Diponegoro No. 69, Jakarta, 10430, Indonesia; Febinia, C.A., Eijkman Institute for Molecular Biology, Ministry of Research and Technology/National Research and Innovation Agency, Jl. Diponegoro No. 69, Jakarta, 10430, Indonesia; Daya, M., Department of Nutrition, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Artika, I.M., Department of Biochemistry, Faculty of Mathematics and Natural Sciences, Bogor Agricultural University, Kampus IPB Dramaga, Jl. Raya Dramaga, Bogor, West Java 16680, Indonesia, Eijkman Institute for Molecular Biology, Ministry of Research and Technology/National Research and Innovation Agency, Jl. Diponegoro No. 69, Jakarta, 10430, Indonesia; Malik, S.G., Eijkman Institute for Molecular Biology, Ministry of Research and Technology/National Research and Innovation Agency, Jl. Diponegoro No. 69, Jakarta, 10430, Indonesia |
Objective: Recent studies showed that genetic polymorphisms in the fat mass and obesity-associated gene (FTO) were associated with obesity and dietary intake. In this study of 71 adults in Jakarta, Indonesia, we investigated FTO rs1421085 association with body mass index (BMI), macronutrient intake, and fatty acid intake. The association was evaluated using linear regression analyses assuming co-dominant, dominant, recessive, over-dominant, and additive genetic models. Results: Only individuals with the CC genotype had a considerably higher BMI (p < 0.001), which indicates a recessive genetic trait, but the incidence for this genotype is low (68 TT + TC vs. 3 CC). Individuals with the minor C allele had an estimated increase of fat intake by 3.45–4.06% across various genetic models (dominant: p < 0.010, over-dominant: p < 0.030, additive: p < 0.010). Subjects with TC/CC genotypes had increased dietary monounsaturated fatty acid (MUFA; 1.14%, p = 0.046) and saturated fatty acid (SAFA; 2.06%, p = 0.023) intakes, compared to those with the TT genotype. In conclusion, our study provided evidence for the association between FTO rs1421085 risk allele with higher BMI and individual preferences for consuming more fat, MUFA, and SAFA. This study highlights the important role of FTO gene in food preference, and its influence on body weight. © 2021, The Author(s). |
Fat intake; Fatty acid; FTO; Indonesia; Obesity; rs1421085 |
alpha ketoglutarate dependent dioxygenase FTO; fatty acid; FTO protein, human; adult; body mass; genetic predisposition; genetics; genotype; human; Indonesia; single nucleotide polymorphism; Adult; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Body Mass Index; Fatty Acids; Genetic Predisposition to Disease; Genotype; Humans; Indonesia; Polymorphism, Single Nucleotide |
BioMed Central Ltd |
17560500 |
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34743743 |
Article |
Q2 |
608 |
8303 |
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50 |
Sitorus R.S., Pambudy I.M., Rohsiswatmo R., Barliana J.D., Yulia D.E., Widyahening I.S. |
57221587271;57327482000;55533574600;57200964187;57225947931;54893154400; |
Retinal abnormalities in universal eye screening of healthy, full-term newborn infants in Jakarta. The incidence and its risk factors: a pilot study |
2021 |
International Journal of Retina and Vitreous |
7 |
1 |
67 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118713835&doi=10.1186%2fs40942-021-00337-1&partnerID=40&md5=e2db9f11d6ce04fd383ce64dbf98b9fa |
Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jalan Kimia No. 8-10, Jakarta, 10320, Indonesia; Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Sitorus, R.S., Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jalan Kimia No. 8-10, Jakarta, 10320, Indonesia; Pambudy, I.M., Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jalan Kimia No. 8-10, Jakarta, 10320, Indonesia; Rohsiswatmo, R., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Barliana, J.D., Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jalan Kimia No. 8-10, Jakarta, 10320, Indonesia; Yulia, D.E., Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jalan Kimia No. 8-10, Jakarta, 10320, Indonesia; Widyahening, I.S., Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Aim: To screen for ocular abnormalities in healthy full-term newborn infants using wide-field digital imaging and to analyze factors associated with the findings. Methods: A total of 1208 full-term newborn infants at a tertiary eye hospital (Cipto Mangunkusumo National Referral Hospital) and a district hospital in Jakarta (Koja Hospital) were enrolled to the study. All eligible newborns underwent fundus examination within 48 h after birth using the RetCam shuttle (Natus Medical Incorporated, USA). Retinal findings were documented and analyzed according to obstetric and neonatal risk factors. Results: Of the 1208 newborn infants enrolled, ocular abnormalities were found in 150 infants (12.4%). Retinal hemorrhage (RH) was the most common finding (88%) in which 2.67% involved the macula, followed by chorioretinitis (4.67%). Univariate analysis showed caesarean section (C-section) (OR 0.27, 95% CI 0.18–0.41, p < 0.001) was a protective factor against RH, while prolonged labor increased the risk of developing RH (OR 1.84, 95% CI 1.24–2.72, p = 0.002). Further multivariate analysis showed similar protective association between C-section and risk of RH (OR 0.29, 95% CI 0.19–0.44, p < 0.001), while other risk factors were not. Conclusions: Our study showed that universal eye screening in healthy neonates is beneficial in the early diagnosis, monitoring and treatment of ocular abnormalities such as retinal hemorrhage, chorioretinitis and retinoblastoma. Retinal hemorrhage is the most common ocular abnormality and is associated with the delivery method and the duration of labor. Universal eye screening is visual-saving and life-saving for neonates with chorioretinitis, retinoblastoma as well as other abnormalities and should be mandatory in newborn screening. © 2021, The Author(s). |
Delivery; Healthy newborn; Hemorrhage; Universal eye screening |
antibiotic agent; local anesthetic agent; phenylephrine; tropicamide; Article; cesarean section; chorioretinitis; coloboma; controlled study; cross-sectional study; digital imaging; early diagnosis; eye examination; female; human; incidence; intraocular tumor; macular degeneration; major clinical study; male; newborn; newborn screening; optic nerve disease; patient referral; pediatric patient; pilot study; retina disease; retina hemorrhage; retina macula hemorrhage; retina macula lutea; retina maculopathy; retinoblastoma; risk factor; vitreous hemorrhage |
BioMed Central Ltd |
20569920 |
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Article |
Q1 |
1617 |
1984 |
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