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710 |
Putrantyo I., Anilbhai N., Vanjani R., De Vega B. |
57268843400;57268843500;57268728700;57222467939; |
Tantalum as a novel biomaterial for bone implant: A literature review |
2021 |
Journal of Biomimetics, Biomaterials and Biomedical Engineering |
52 |
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55 |
65 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115443615&doi=10.4028%2fwww.scientific.net%2fJBBBE.52.55&partnerID=40&md5=23de679861db060839b35e7a1cc36b26 |
Division of Surgery and Interventional Science, University College London, Royal Free Hospital Campus, London, United Kingdom; Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Cell & Tissue Bank, Dr Soetomo General Hospital, Surabaya, Indonesia |
Putrantyo, I., Division of Surgery and Interventional Science, University College London, Royal Free Hospital Campus, London, United Kingdom, Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Anilbhai, N., Division of Surgery and Interventional Science, University College London, Royal Free Hospital Campus, London, United Kingdom; Vanjani, R., Division of Surgery and Interventional Science, University College London, Royal Free Hospital Campus, London, United Kingdom; De Vega, B., Division of Surgery and Interventional Science, University College London, Royal Free Hospital Campus, London, United Kingdom, Cell & Tissue Bank, Dr Soetomo General Hospital, Surabaya, Indonesia |
Titanium (Ti) has been used in metallic implants since the 1950s due to various biocompatible and mechanical properties. However, due to its high Young’s modulus, it has been modified over the years in order to produce a better biomaterial. Tantalum (Ta) has recently emerged as a new potential biomaterial for bone and dental implants. It has been reported to have better corrosion resistance and osteo-regenerative properties as compared to Ti alloys which are most widely used in the bone-implant industry. Currently, Tantalum cannot be widely used yet due to its limited availability, high melting point, and high-cost production. This review paper discusses various manufacturing methods of Tantalum alloys, including conventional and additive manufacturing and also discusses their drawbacks and shortcomings. Recent research includes surface modification of various metals using Tantalum coatings in order to combine bulk material properties of different materials and the porous surface properties of Tantalum. Design modification also plays a crucial role in controlling bulk properties. The porous design does provide a lower density, wider surface area, and more immense specific strength. In addition to improved mechanical properties, a porous design could also escalate the material's biological and permeability properties. With current advancement in additive manufacturing technology, difficulties in processing Tantalum could be resolved. Therefore, Tantalum should be considered as a serious candidate material for future bone and dental implants. © 2021 Trans Tech Publications Ltd, Switzerland. |
Bone implant; Porous metal; Porous structure; Surface coating; Tantalum |
3D printers; Additives; Biocompatibility; Coatings; Corrosion resistant alloys; Dental alloys; Dental prostheses; Mechanical permeability; Metal implants; Porosity; Tantalum alloys; Titanium alloys; Bone implant; High costs; High melting point; Literature reviews; Metallic implants; Porous metal; Porous structures; Property; Surface coatings; Titanium (alloys); Corrosion resistance |
Trans Tech Publications Ltd |
22969837 |
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Article |
Q4 |
183 |
20493 |
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713 |
Mulyadi R., Hatta M., Islam A.A., Murtala B., Tammase J., Firdaus M., Susanto E., Prihartono J. |
56403164500;8134403900;55504893500;57216630400;57216632154;57220366722;57204423225;6602605635; |
Intratumoral and Peritumoral Apparent Diffusion Coefficient and MGMT mRNA Expression in Different Meningioma Histopathological Grade |
2021 |
Indonesian Biomedical Journal |
13 |
1 |
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97 |
105 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115108397&doi=10.18585%2finabj.v13i1.1338&partnerID=40&md5=22848104129d76ff75e6024180be5997 |
Neuroradiology Division, Department of Radiology, Faculty of Medicine, Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia; Molecular Biology and Immunology Laboratory, Faculty of Medicine, Universitas Hasanuddin, Jl. Perintis Kemerdekaan KM 10, Makassar, 90245, Indonesia; Department of Neurosurgery, Faculty of Medicine, Universitas Hasanuddin, Jl. Perintis Kemerdekaan KM 10, Makassar, 90245, Indonesia; Department of Radiology, Faculty of Medicine, Universitas Hasanuddin, Jl. Perintis Kemerdekaan KM 10, Makassar, 90245, Indonesia; Department of Neurology, Faculty of Medicine, Universitas Hasanuddin, Jl. Perintis Kemerdekaan KM 10, Makassar, 90245, Indonesia; Department of Neurosurgery, Dharmais Hospital National Cancer Center, Jl. Letjen Jend. S. Parman No.84-86, Jakarta, 11420, Indonesia; Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia |
Mulyadi, R., Neuroradiology Division, Department of Radiology, Faculty of Medicine, Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia; Hatta, M., Molecular Biology and Immunology Laboratory, Faculty of Medicine, Universitas Hasanuddin, Jl. Perintis Kemerdekaan KM 10, Makassar, 90245, Indonesia; Islam, A.A., Department of Neurosurgery, Faculty of Medicine, Universitas Hasanuddin, Jl. Perintis Kemerdekaan KM 10, Makassar, 90245, Indonesia; Murtala, B., Department of Radiology, Faculty of Medicine, Universitas Hasanuddin, Jl. Perintis Kemerdekaan KM 10, Makassar, 90245, Indonesia; Tammase, J., Department of Neurology, Faculty of Medicine, Universitas Hasanuddin, Jl. Perintis Kemerdekaan KM 10, Makassar, 90245, Indonesia; Firdaus, M., Department of Neurosurgery, Dharmais Hospital National Cancer Center, Jl. Letjen Jend. S. Parman No.84-86, Jakarta, 11420, Indonesia; Susanto, E., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia; Prihartono, J., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia |
BACKGROUND: Histopathological examination is the gold standard for diagnosing meningioma and determining the treatments. However, it is invasive in nature. This study was conducted to identify intratumoral and peritumoral apparent diffusion coefficient (ADC) value and mRNA O6-methylguanine-DNA methyltransferase (MGMT) expression in meningioma. METHODS: Data were collected from 39 patients who were clinically diagnosed with meningioma. However, only 37 patients met the inclusion criteria. These subjects then underwent examinations and received treatment from October 2017 to September 2018. Magnetic resonance imaging (MRI) data with diffusion-weighted imaging-apparent diffusion coefficient (DWI-ADC) sequence, histopathological diagnosis of meningioma, and results of MGMT mRNA expression were obtained. RESULTS: The most frequent type of low-grade and overall tumor was meningioma not otherwise specified (56.8%). For high-grade tumor, there were two atypical cases: atypical meningioma (2.7%) and rhabdoid meningioma (2.7%). Meningothelial meningioma had the highest mean value of minimum intratumoral ADC at 864.57±219 x10-3 mm2/s, whereas rhabdoid meningioma had the lowest at 417 x10-3 mm2/s. For minimum peritumoral ADC, rhabdoid meningioma had the highest mean value at 1,651 x10-3 mm2/s, while atypical meningioma has the lowest at 1,281 x10-3 mm2/s. For MGMT mRNA, meningothelial meningioma had the highest mean value at 10±1.2 fold change, whereas rhabdoid meningioma had the lowest mean at 6.18 fold change. CONCLUSION: WHO grade I meningiomas had higher minimum intratumoral ADC values and higher MGMT mRNA expression than the high-grade tumors. Minimum peritumoral ADC values differed across the histopathological grades. © 2021. All Rights Reserved. |
ADC; meningioma; messenger; methyltransferases; MGMT mRNA; MRI; RNA; RT-PCR |
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Prodia Education and Research Institute |
20853297 |
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Article |
Q4 |
160 |
22228 |
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716 |
Dewi S., Sadikin M., Mulyawan W. |
57192904541;36981411100;57192910410; |
Oxidative stress in the heart of rats exposed to acute intermittent hypobaric hypoxia |
2021 |
Ukrainian Biochemical Journal |
93 |
3 |
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68 |
74 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114748388&doi=10.15407%2fubj93.03.068&partnerID=40&md5=a11d4d4d31ac5bf34a38f63a8507d433 |
Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Aerophysiology, Air Force Indonesian National Army, Lakespra Saryanto, Jakarta, Indonesia |
Dewi, S., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sadikin, M., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mulyawan, W., Department of Aerophysiology, Air Force Indonesian National Army, Lakespra Saryanto, Jakarta, Indonesia |
It is known that the altitude area causes hypoxic conditions due to the low oxygen partial pressure. This study was conducted to estimate oxidative stress indices in the heart tissue after Wister rats exposure to the acute intermittent hypobaric hypoxia. Hypobaric hypoxia exposure was simulated by keeping the rats in a hypobaric chamber for 1 min at 35,000 feet altitude. After that the altitude was gradually reduced to 30,000 and 25,000 feet and maitained for 5 min. 25 male Wistar rats were divided into control group and four treatment groups (I-IV), consisting of rats exposed 1, 2, 3 and 4 times to hypobaric hypoxia with a frequency once a week. The animals were removed from the experiment at the height of 18,000 feet and the heart tissue was obtained. The carbonyl groups and MDA levels and superoxide dismutase and catalase activity were exami-ned in the supernatant of the heart tissue homogenate. In the samples of group I, the decrease in catalase activity with a simultaneous notable increase in carbonyl groups level was observed compared to control. In the samples of groups III and IV, the carbonyl level normalized and the activity of both antioxidant enzymes increased significantly. It was concluded that the increase of antioxidant enzymes activity can contribute to cardiac tissue adaptive response to acute hypobaric hypoxia exposure. © 2021 Dewi S. et al. |
Acute intermittent hypobaric hypoxia; Antioxidant enzymes; Heart; Oxidative stress |
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Palladin Institute of Biochemistry of the NASU |
24094943 |
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Article |
Q4 |
173 |
21241 |
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734 |
Pudjiadi A.H. |
18435202300; |
Sepsis-induced T-cell suppression in pediatric sepsis |
2021 |
Critical Care and Shock |
2021 |
July |
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172 |
180 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112603065&partnerID=40&md5=f1958f220fe6de69e13b086f449c61df |
Department of Child Health, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Pudjiadi, A.H., Department of Child Health, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Sepsis contributes to significant mortality and morbidity in children. Despite rigorous resusci-tation effort, adequate antibiotics and advanced medical support, a significant proportion still face mortality due to multiple organ failure. Re-. cent hypothesis suggests host’s immune response pathology in the form of compensatory anti-in-flammatory response syndrome (CARS). This review aims to elucidate the pathophysiology of immune paralysis, both affecting innate and acquired immunity. © 2021, The Indonesian Foundation of Critical Care Medicine. All rights reserved. |
Compensatory anti-inflammatory response syndrome; HLA-DR; Immunoparalysis; Sepsis; TNF-α |
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The Indonesian Foundation of Critical Care Medicine |
14107767 |
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Review |
Q4 |
134 |
24890 |
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737 |
Cheah F.-C., Tan T.-L., Herulah U., Dilantika C., Muhardi L., Deshpande G., Rohsiswatmo R., Saluja S., Van Elburg R. |
6603939153;57221865957;56682082100;35490282300;57216729101;16432470300;55533574600;57206226525;7004570423; |
Recommendations to promote breast milk feeding and enhance nutritional care for preterm infants in the Asia-Pacific region: Highlights from a roundtable discussion of key opinion leaders |
2021 |
Malaysian Journal of Nutrition |
27 |
2 |
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201 |
207 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112264614&doi=10.31246%2fMJN-2020-0124&partnerID=40&md5=6c8041236a4fe926cd7bde67a5a705d9 |
Department of Paediatrics, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia; Danone Nutricia Early Life Nutrition, Sydney, Australia; Danone Nutricia Early Life Nutrition, Jakarta, Indonesia; Nepean Hospital, Sydney, Sydney Medical School Nepean, University of Sydney, Australia; Division of Perinatology, Department of Pediatrics, Faculty of Medicine, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Neonatology Department, Sir Ganga Ram Hospital, New Delhi, India; Department of Pediatrics, Emma Children’s Hospital Amsterdam University Medical Center, Amsterdam, Netherlands |
Cheah, F.-C., Department of Paediatrics, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia; Tan, T.-L., Department of Paediatrics, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia; Herulah, U., Danone Nutricia Early Life Nutrition, Sydney, Australia; Dilantika, C., Danone Nutricia Early Life Nutrition, Jakarta, Indonesia; Muhardi, L., Danone Nutricia Early Life Nutrition, Jakarta, Indonesia; Deshpande, G., Nepean Hospital, Sydney, Sydney Medical School Nepean, University of Sydney, Australia; Rohsiswatmo, R., Division of Perinatology, Department of Pediatrics, Faculty of Medicine, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Saluja, S., Neonatology Department, Sir Ganga Ram Hospital, New Delhi, India; Van Elburg, R., Department of Pediatrics, Emma Children’s Hospital Amsterdam University Medical Center, Amsterdam, Netherlands |
Introduction: Preterm infants are vulnerable to nutritional deficiencies, thus optimal nutrition is crucial in promoting growth among these infants. However, socio-cultural complexities and limited resources in the Asia-Pacific demands a judicious approach in implementing nutritional care that is pragmatic to align with current evidence-based recommendations. Methods: A roundtable meeting was held in Jakarta in 2017 for key opinion leaders in neonatology from the Asia- Pacific to discuss issues when delivering nutritional care in this region and the unique circumstances encountered. Results: Priority areas discussed include: (i) breast milk feeding, (ii) donor milk bank/sharing, (iii) human milk fortification, and (iv) nutrient-enriched breast milk substitutes. Socio-cultural practices impeding breastfeeding, insufficient maternity leave, the religious issue of milk kinship, and limited availability of specialty nutritional care products were among the most challenging factors. Conclusion: The group proposed recommendations to enhance breastfeeding uptake, accessibility to a complete portfolio of specialty nutritional care products, and encouraging more active collaborations to engage policy makers in addressing these contemporary issues. © 2021 |
Breastfeeding; donor human milk; human milk fortifier; milk kinship; preterm infant |
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Malaysian Journal of Nutrition |
1394035X |
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Short Survey |
Q4 |
192 |
19873 |
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745 |
Syam A.F. |
8443384400; |
Gastrointestinal disorders in covid-19 patients: A great imitator |
2021 |
Medical Journal of Indonesia |
30 |
2 |
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166 |
169 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111112690&doi=10.13181%2fmji.bc.204960&partnerID=40&md5=1e55d25030cd22add972a3dac84c5ac5 |
Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Syam, A.F., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Up to this point, the coronavirus disease 2019 (COVID-19) pandemic is still ongoing. Some studies with a large number of cases have reported its clinical manifestations, concluding that the disease is a great imitator. Patients may present with symptoms other than the main symptoms of respiratory tract infections, such as diarrhea, abdominal pain, nausea, or vomiting, which may sometimes cause a delayed treatment in managing COVID-19 patients. Reports of various hospitals have also demonstrated gastrointestinal complaints as a clinical manifestation in those patients. The patients may come with gastrointestinal symptoms as their early clinical manifestation, or the gastrointestinal symptoms may be found in hospitalized COVID-19 patients, which indeed can be explained since the SARS-CoV-2, an etiologic agent of COVID-19 infection, can obviously be found along the gastrointestinal tract. Hence, the virus can be found in fecal and anal, and therefore, rectal swabs can be used as a diagnostic tool for COVID-19 infection. © 2021 Author. |
COVID-19; Gastrointestinal disease; SARS-CoV-2 |
alkaline phosphatase; angiotensin converting enzyme 2; aspartate aminotransferase; transmembrane protease serine 2; virus RNA; anal swab; Article; coronavirus disease 2019; coughing; diabetes mellitus; diarrhea; dyspnea; epigastric pain; feces analysis; fever; gastrointestinal disease; gastrointestinal symptom; gastrointestinal tract; human; hypertension; inflammatory bowel disease; lung lavage; nasopharyngeal swab; nausea and vomiting; nonhuman; pneumonia; real time reverse transcription polymerase chain reaction; rectal swab; RNA virus; Severe acute respiratory syndrome coronavirus 2; stomach pain; thorax radiography; virus transmission |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Article |
Q4 |
164 |
21905 |
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748 |
Karina K., Ekaputri K., Biben J.A., Purwoko R.H., Sibuea T.P., Astuti S.L., Loho A.M., Limengka Y., Nelfidayani, Agustini S., Krisandi G., Maryam A., Rosadi I., Rosliana I., Sobariah S., Subroto W.R., Afini I., Widyastuti T., Zakiyah A., Ernanda D., Aini N., Jusryanti, Sulaeha A.D., Prestiani S.I., Donna I.M., Habibi, Mutiara M.S. |
57212146678;57285088000;55947833300;57286031400;57286487800;57285797400;57223264641;37029815800;57286487900;57286488000;57225009844;57286260300;57204720098;57186671400;57203547382;57218940654;57211068324;57211074403;57226293808;57226273639;57226289464;57286944600;57226286645;57283770100;57284210300;57285797500;57284210400; |
Evaluating the Safety of Intravenous Delivery of Autologous Activated Platelet-rich Plasma |
2021 |
Journal of Health Sciences |
11 |
2 |
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61 |
65 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111033469&doi=10.17532%2fjhsci.2021.1276&partnerID=40&md5=b0a026ecaccc92d972564c5dfd1f4824 |
Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia; Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, Jakarta, Indonesia; Pusat Kajian Stem Cell, Universitas Pembangunan Nasional Veteran Jakarta, Jakarta, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, Mulawarman University, Indonesia |
Karina, K., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia, Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, Jakarta, Indonesia, Pusat Kajian Stem Cell, Universitas Pembangunan Nasional Veteran Jakarta, Jakarta, Indonesia; Ekaputri, K., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Biben, J.A., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Purwoko, R.H., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Sibuea, T.P., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Astuti, S.L., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Loho, A.M., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Limengka, Y., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Nelfidayani, Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Agustini, S., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Krisandi, G., Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Maryam, A., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Rosadi, I., Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia, Department of Biology, Faculty of Mathematics and Natural Sciences, Mulawarman University, Indonesia; Rosliana, I., Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia; Sobariah, S., Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia; Subroto, W.R., Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia; Afini, I., Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia; Widyastuti, T., Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia; Zakiyah, A., Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia; Ernanda, D., Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia; Aini, N., Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia; Jusryanti, Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Sulaeha, A.D., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Prestiani, S.I., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Donna, I.M., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Habibi, Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia; Mutiara, M.S., Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta, Indonesia |
Introduction: Autologous platelet-rich plasma (PRP) has been a growing trend in the field of medicine due to its broad range of application and is considered safe from bloodborne diseases. Furthermore, various studies have tried to optimize the use of autologous PRP through various preparation protocols, including PRP activation. However, most of the studies available have not evaluated the safety for intravenous delivery of PRP, especially autologous activated PRP (aaPRP). Therefore, this study aimed to evaluate the safety of intravenous delivery of aaPRP. Methods: Blood was drawn from each patient and aaPRP was isolated through calcium activation and light irradiation. Each aaPRP was administered intravenously to all patients. Adverse events were documented and analyzed. Results: Six hundred eleven patients participated in this study with a total of 4244 aaPRP therapies. Quality control of autologous aaPRP showed no platelets present after both calcium activation and light irradiation. No adverse events such as allergic reaction, infection, and coagulation problems were observed on all patients over the course of the study. Conclusion: Our results showed that intravenous administration of autologous aaPRP is safe even in patients with various pathological conditions. © 2021. Karina Karina, et al.; licensee University of Sarajevo - Faculty of Health Studies. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Intravenous infusion; platelet-rich plasma; safety |
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University of Sarajevo - Faculty of Health Studies |
22327576 |
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Article |
Q4 |
112 |
28273 |
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749 |
Victor A.A., Yandandri V.R., Gondowiardjo T.D., Dharma R., Jusman S.W., Prihartono J. |
57191055282;57226248415;54956727400;12777817700;36518792100;6602605635; |
Effect of laser photocoagulation before vitrectomy to hypoxia inducible factor-1alfa and intracellular adhesive molecule-1 in diabetic patients: A randomized clinical trial |
2021 |
Retina-Vitreus |
30 |
2 |
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204 |
211 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110980758&doi=10.37845%2fret.vit.2021.30.37&partnerID=40&md5=0facab036ffe38e8aaf9f0feeac57868 |
Faculty of Medicine, Cipto Mangunkusumo National General Hospital, Ophthalmology, DKI Jakarta, Indonesia; Faculty of Medicine, Clinical Pathology, DKI Jakarta, Jakarta, Indonesia; Faculty of Medicine, Biochemistry Department, Faculty of Medicine, University of Indonesia, DKI Jakarta, Indonesia; Faculty of Medicine, Community Department, Faculty of Medicine, University of Indonesia, DKI Jakarta, Indonesia |
Victor, A.A., Faculty of Medicine, Cipto Mangunkusumo National General Hospital, Ophthalmology, DKI Jakarta, Indonesia; Yandandri, V.R., Faculty of Medicine, Cipto Mangunkusumo National General Hospital, Ophthalmology, DKI Jakarta, Indonesia; Gondowiardjo, T.D., Faculty of Medicine, Cipto Mangunkusumo National General Hospital, Ophthalmology, DKI Jakarta, Indonesia; Dharma, R., Faculty of Medicine, Clinical Pathology, DKI Jakarta, Jakarta, Indonesia; Jusman, S.W., Faculty of Medicine, Biochemistry Department, Faculty of Medicine, University of Indonesia, DKI Jakarta, Indonesia; Prihartono, J., Faculty of Medicine, Community Department, Faculty of Medicine, University of Indonesia, DKI Jakarta, Indonesia |
Purpose: The vitreous concentration of Hypoxia-inducible Factor-1α (HIF-1α) and Intercellular Adhesive Molecule-1 (ICAM-1) were related to the permeability of retinal vessels and the grades of macular edema in proliferative diabetic retinopathy (PDR). Prior studies have showed that pan-retinal photocoagulation (PRP) is benefi cial in treating PDR. The aim of this study is to determine how pre-treatment with PRP before vitrectomy affect the vitreous level of HIF-1 and ICAM-1 in patients with PDR. Materials and Methods: A randomized clinical trial study was conducted to 22 eyes in Cipto Mangunkusumo National General Hospital, Indonesia. At the beginning of PRP, just before vitrectomy, and at 2, 4, and 12 weeks after vitrectomy, central macular thickness (CMT) was measured using optical coherence tomography (OCT). Undiluted vitreous humour was extracted during vitrectomy to obtain HIF-1α and ICAM-1 concentration. Results: In the control and the photocoagulation group, the average level of HIF-1α (ng/mL) were 0.152±0.015 and 0.164±0.033 respectively. The average level of ICAM-1 (ng/mL) in control group and pre-treated group were 17,840±14,140 and 27,027±10,452 respectively. No statistically signifi cant difference was seen in the level of HIF-1α and ICAM-1 between each group. The correlation between vitreous ICAM- 1 and HbA1c was statistically signifi cant (r=0.463, p=0.03). No signifi cant differences for CMT at pre-vitrectomy, or 2 and 4 weeks after vitrectomy. Statistically signifi cant difference was observed at 12 weeks after follow-up (p=0.049). The correlation between vitreous level of HIF-Iα and CMT in the control and laser group are r = 0.447 and r = 0.32, respectively. Conclusion: Laser photocoagulation 1-2 weeks prior to vitrectomy did not lower vitreous concentration of HIF-1α and ICAM-1. © 2021 Gazi Eye Foundation. All rights reserved. |
Diabetic retinopathy; Hypoxia-Inducible Factor 1; Intercellular Adhesion Molecule-1; Light coagulation |
hypoxia inducible factor 1alpha; intercellular adhesion molecule 1; adult; Article; cataract; central macular thickness; controlled study; diabetic patient; female; follow up; glaucoma; human; hyphema; laser coagulation; major clinical study; male; middle aged; optical coherence tomography; pars plana vitrectomy; proliferative diabetic retinopathy; randomized controlled trial; retina blood vessel; retina detachment; vitrectomy; vitreous body; vitreous hemorrhage |
Gazi Eye Foundation |
13001256 |
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Article |
Q4 |
110 |
28729 |
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750 |
Amalia R., Bustamam A., Yudantha A.R., Victor A.A. |
57226194312;36815737800;55489644900;57191055282; |
Diabetic retinopathy detection and captioning based on lesion features using deep learning approach |
2021 |
Communications in Mathematical Biology and Neuroscience |
2021 |
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59 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110864476&doi=10.28919%2fcmbn%2f5832&partnerID=40&md5=e3e95d1370fc8ff4347362007e9add2e |
Department of Mathematics, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, 16424, Indonesia; Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia Cipto Mangunkusumo National General Hospital, Jakarta Pusat, 10430, Indonesia |
Amalia, R., Department of Mathematics, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, 16424, Indonesia; Bustamam, A., Department of Mathematics, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, 16424, Indonesia; Yudantha, A.R., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia Cipto Mangunkusumo National General Hospital, Jakarta Pusat, 10430, Indonesia; Victor, A.A., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia Cipto Mangunkusumo National General Hospital, Jakarta Pusat, 10430, Indonesia |
Diabetic Retinopathy (DR) can lead to vision loss if the patient does not get effective treatment based on the patient’s condition. Early detection is needed to know what an effective treatment for those patients is. For helping ophthalmologists, DR detection methods using computer-based were developed. Ophthalmologists can use the result of the method as a consideration in diagnosing the class of DR. One of the powerful methods is deep learning. The proposed method uses two deep learning architectures, namely Convolutional Neural Network (CNN) and Recurrent Neural Network (RNN), for DR detection. CNN is used to detect DR lesion features, and RNN is used for captioning based on those lesion features. We used three pre-trained CNN models, including AlexNet, VGGNet and GoogleNet, and used Long Short-Term Memory (LSTM) as RNN models. In the image preprocessing, we applied contrast enhancement using Contrast Limited Adaptive Histogram Equalization (CLAHE) and compared the results with those without CLAHE. We have done the training and testing process with a different proportion of data. The experimental results show that our proposed method can detect the lesion features and generate caption with the highest average accuracy of 96.12% for GoogleNet and LSTM with CLAHE and the proportion 70% training data 30% testing data. © 2021 the author(s). |
Convolutional neural network (CNN); Deep learning; Diabetic retinopathy; Long short-term memory (LSTM) |
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SCIK Publishing Corporation |
20522541 |
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Article |
Q4 |
189 |
20081 |
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751 |
Soetikno V. |
36769252100; |
The importance of registry for systematic review and clinical trial |
2021 |
Medical Journal of Indonesia |
30 |
2 |
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87 |
88 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110707318&doi=10.13181%2fmji.ed.215620&partnerID=40&md5=f191fe1a910178e15d2b72bb4de9df1c |
Medical Journal of Indonesia, Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Soetikno, V., Medical Journal of Indonesia, Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
[No abstract available] |
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placebo; Cochrane Library; controlled study; data extraction; Editorial; erectile dysfunction; evaluation study; health care policy; human; medical literature; Medline; mesenchymal stem cell; meta analysis; outcome assessment; Preferred Reporting Items for Systematic Reviews and Meta-Analyses; publication; publication bias; questionnaire; randomized controlled trial; register; review; risk assessment; search engine; systematic review |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Editorial |
Q4 |
164 |
21905 |
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