|
No records
|
|
1 |
Sudjono C.; Quinncilla K.H.; Qonita M.; Wijaya N.J.; Kurnain D. |
Sudjono, Clinton (59196697600); Quinncilla, Kiara Hanna (59136515900); Qonita, Ms (59195443000); Wijaya, Nicholas Jason (58483356100); Kurnain, Dave (59196070600) |
59196697600; 59136515900; 59195443000; 58483356100; 59196070600 |
Early Menarche as a Protective Factor Against Cardiovascular Events: A Systematic Review and Meta-analysis |
2024 |
Anatolian journal of cardiology |
28 |
7 |
|
329 |
338 |
9 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85197189251&doi=10.14744%2fAnatolJCardiol.2024.3996&partnerID=40&md5=fcfbfda7ab7b31922e8582c997fc0e7a |
Department of Cardiology, Faculty of Medicine, Tarumanagara University, Jakarta, Indonesia; Sebelas Maret University, Surakarta, Indonesia; Jenderal Soedirman University, Purwokerto, Indonesia; Undergraduate Medical Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Sudjono C., Department of Cardiology, Faculty of Medicine, Tarumanagara University, Jakarta, Indonesia; Quinncilla K.H., Sebelas Maret University, Surakarta, Indonesia; Qonita M., Jenderal Soedirman University, Purwokerto, Indonesia; Wijaya N.J., Undergraduate Medical Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kurnain D., Department of Cardiology, Faculty of Medicine, Tarumanagara University, Jakarta, Indonesia |
BACKGROUND: Women are often neglected in cardiovascular health prevention. Age at menarche (AAM) has been linked to cardiovascular (CVD) disease in women and is potentially identified as one of the significant CVD risk factor. However, there is still limited comprehensive evidence addressing this issue. This systematic review and meta-analysis aimed to investigate how early menarche affects the outcome of all-cause mortality, CVD mortality, total cardiovascular disease event, stroke (ischemic, hemorrhagic, and total stroke), and coronary heart disease (CHD). METHOD: The Cochrane Library, MEDLINE, Embase, ScienceDirect, and Google Scholar databases were searched from March 2013 to March 2023 for cohorts investigating the effect of early onset of menarche on CVD events with a minimum follow-up period of 5 years. Studies that observed specific population and/or included women with a history of CVD at baseline were excluded. The Newcastle-Ottawa scale was used for risk of bias assessment for each cohort included. The data were presented as dichotomous measure using risk ratios. I2 statistics were utilized to evaluate the heterogeneity of presented data. RESULTS: Thirteen cohorts included 18 626 799 female patients with ages ranging from 43 to 62.6 years. These reported 6 estimates each for CHD (5 483 298 patients) and all-cause mortality (1 595 878 patients), 5 estimates each for total stroke (2 941 321 patients) and CVD mortality (1 706 742 patients), 4 estimates each for total CVD events (3 988 311 patients) and ischemic stroke (2 434 580 patients), and 1 estimate for hemorrhagic stroke (66 104 patients). Our study found that events of CHD were significantly lower in early menarche (RR 0.57; 95% CI 0.41-0.78; P <.00001), as well as total stroke (RR 0.51; 95% CI 0.35-0.73; P =.0003), CVD mortality (RR 0.47; 95% CI 0.22-0.98; P =.04), total CVD events (RR 0.44; 95% CI 0.25-0.76; P =.003), ischemic stroke (RR 0.31; 95% CI 0.15-0.61; P <.0008), and hemorrhagic stroke (RR 0.12; 95% CI 0.07-0.20; P <.00001); and insignificantly higher in all-cause mortality (RR 0.90, 95% CI 0.76-1.06, P =.20). CONCLUSION: In our study, cardiovascular events are lower in women with early menarche; hence, the later age of menarche is a potential risk factor to be considered when assessing CVD risk in a patient. However, our sample characteristics were heterogenous, and we did not consider other female hormonal factors that might potentially contribute to the CVD outcomes observed; thus, further studies are needed to clarify. |
|
Age Factors; Cardiovascular Diseases; Female; Humans; Menarche; Middle Aged; Protective Factors; Risk Factors; age; cardiovascular disease; female; human; menarche; meta analysis; middle aged; mortality; prevention and control; protection; risk factor |
|
|
|
21492271 |
|
38940409 |
Article |
Q3 |
290 |
15434 |
|
|
|
71 |
Karyanti M.R.; Uiterwaal C.S.P.M.; Hadinegoro S.R.; Widyahening I.S.; Saldi S.R.F.; Heesterbeek J.A.P.H.; Hoes A.W.; Bruijning-Verhagen P. |
Karyanti, Mulya Rahma (56290680800); Uiterwaal, Cuno S P M (59148037600); Hadinegoro, Sri Rezeki (56893685800); Widyahening, Indah Suci (54893154400); Saldi, Siti Rizny F (55201904000); Heesterbeek, J A P Hans (59134733500); Hoes, Arno W. (35370614300); Bruijning-Verhagen, Patricia (55175644800) |
56290680800; 59148037600; 56893685800; 54893154400; 55201904000; 59134733500; 35370614300; 55175644800 |
The Value of Warning Signs From the WHO 2009 Dengue Classification in Detecting Severe Dengue in Children |
2024 |
The Pediatric infectious disease journal |
43 |
7 |
|
630 |
634 |
4 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85196767536&doi=10.1097%2fINF.0000000000004326&partnerID=40&md5=04c0ef35f4c83ec1bb4da39449b609c4 |
From the Department of Child Health, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands; Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Clinical Epidemiology and Evidence-Based Medicine Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Population Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands |
Karyanti M.R., From the Department of Child Health, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands; Uiterwaal C.S.P.M., Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands; Hadinegoro S.R., From the Department of Child Health, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Widyahening I.S., Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Saldi S.R.F., Clinical Epidemiology and Evidence-Based Medicine Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Heesterbeek J.A.P.H., Department of Population Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands; Hoes A.W., Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands; Bruijning-Verhagen P., Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands |
BACKGROUND: World Health Organization proposed 7 warning signs to identify the risk of severe dengue in 2009. This study aimed to evaluate the value of these warning signs in detecting severe dengue in children. MATERIAL AND METHODS: A cross-sectional study was conducted utilizing data of children with clinical dengue infection obtained from medical records between January 2009 and December 2018 in Jakarta. Children with confirmed dengue were analyzed and stratified into 3 age groups: infants less than 1 year old, children 1-14 years and adolescents 15-18 years of age. Positive predictive value, negative predictive value (NPV), sensitivity and specificity of each warning sign present or absent on admission in detecting severe dengue were computed. RESULTS: Six hundred ninety-nine children with clinical dengue infection were enrolled, among whom 614 (87.8%) had confirmed dengue infection, either by antigen or antibody serological tests. Severe dengue occurred in 211/614 (34.4%) cases. In infants, important warning signs on admission to detect or exclude severe dengue were liver enlargement (NPV 80.8%) and clinical fluid accumulation (NPV 75%). In children and adolescents, warning sign with highest NPV (in children 76.6% and in adolescents 91.9%) was increase in hematocrit concurrent with a rapid decrease in platelet count. Other warning signs with high NPV values in children were abdominal pain (72%), vomiting (70%), clinical fluid accumulation (69.3%), and in adolescents' abdominal pain (80.7%), vomiting (75.7%), clinical fluid accumulation (82.7%). NPVs increase with more than 1 warning sign in all age groups. CONCLUSION: In infants, liver enlargement or clinical fluid accumulation are important warning signs for severe dengue, when both are absent, severe dengue is unlikely. In older children and adolescents, an increase in hematocrit with the concurrent rapid decrease in platelet count is most discriminative; followed by the absence of abdominal pain, vomiting or fluid accumulation are unlikely severe dengue. Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. |
|
Adolescent; Child; Child, Preschool; Cross-Sectional Studies; Female; Humans; Infant; Male; Sensitivity and Specificity; Severe Dengue; World Health Organization; adolescent; child; cross-sectional study; diagnosis; female; human; infant; male; preschool child; sensitivity and specificity; severe dengue; World Health Organization |
|
|
|
15320987 |
|
38652064 |
Article |
#N/A |
#N/A |
#N/A |
|
|
|
129 |
Basrowi R.W.; Zulfiqqar A.; Sitorus N.L. |
Basrowi, Ray Wagiu (57024210400); Zulfiqqar, Andy (57216205101); Sitorus, Nova Lidia (58156444100) |
57024210400; 57216205101; 58156444100 |
Anemia in Breastfeeding Women and Its Impact on Offspring's Health in Indonesia: A Narrative Review |
2024 |
Nutrients |
16 |
9 |
|
|
|
|
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85192943989&doi=10.3390%2fnu16091285&partnerID=40&md5=cbfd483afe24a61f90bef22ddf6b8604 |
Danone Specialized Nutrition Indonesia, 12940, Jakarta, Indonesia; Occupational Medicine Program, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, 12300, Jakarta, Indonesia; Division of Urology, Department of Surgery, Faculty of Medicine, Universitas Gadjah Mada/Dr. Sardjito Hospital, 55281, Yogyakarta, Indonesia |
Basrowi R.W., Danone Specialized Nutrition Indonesia, 12940, Jakarta, Indonesia, Occupational Medicine Program, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, 12300, Jakarta, Indonesia; Zulfiqqar A., Division of Urology, Department of Surgery, Faculty of Medicine, Universitas Gadjah Mada/Dr. Sardjito Hospital, 55281, Yogyakarta, Indonesia; Sitorus N.L., Danone Specialized Nutrition Indonesia, 12940, Jakarta, Indonesia |
Anemia in breastfeeding women is a neglected global health issue with significant implications for maternal and child health. Despite its widespread occurrence and adverse effects, this problem remains largely unknown and overlooked on the global health agenda. Despite efforts to improve health access coverage and provide iron and folic acid supplementation, anemia persists. This underscores the need for a comprehensive approach to address the problem. Urgent action must be taken to prioritize education and awareness campaigns, ensure access to nutritious food, and enhance healthcare services. Education programs should focus on promoting iron-rich diets, dispelling cultural myths, and providing practical guidance. Improving healthcare services requires increasing availability, ensuring a consistent supply of iron supplements, and providing adequate training for healthcare providers. A successful implementation relies on a strong collaboration between the government, healthcare providers, and community. It is crucial that we acknowledge that high coverage alone is insufficient for solving the issue, emphasizing the importance of targeted interventions and a strategic implementation. By adopting a comprehensive approach and addressing the underlying causes of anemia, Indonesia can make significant progress in reducing its prevalence and improving the overall health of its population, particularly among breastfeeding women. |
anemia; breastfeeding; child health; iron deficiency |
Anemia; Anemia, Iron-Deficiency; Breast Feeding; Child Health; Dietary Supplements; Female; Folic Acid; Humans; Indonesia; Infant; Iron; folic acid; iron; anemia; breast feeding; child health; dietary supplement; female; human; Indonesia; infant; iron deficiency anemia |
|
|
|
20726643 |
|
38732532 |
Review |
Q1 |
1291 |
2754 |
|
|
|
136 |
Tandean S.; Japardi I.; Rusda M.; Indharty R.S.; Lelo A.; Aman R.A.; Amin M.M.; Siahaan A.M.P.; Eyanoer P.C.; D'Prinzessin C.A.; Lesmana R.; Popova M.; Trusheva B.; Bankova V.; Zulhendri F. |
Tandean, Steven (57200655152); Japardi, Iskandar (57200649149); Rusda, Muhammad (57201675676); Indharty, Rr Suzy (57192909801); Lelo, Aznan (59195385200); Aman, Renindra Ananda (36848942500); Amin, Mustafa Mahmud (57201668200); Siahaan, Andre Marolop Pangihutan (57201669352); Eyanoer, Putri Chairani (45561124000); D'Prinzessin, Celine Augla (59196009500); Lesmana, Ronny (55363079700); Popova, Milena (7103172058); Trusheva, Boryana (8542765200); Bankova, Vassya (35479237300); Zulhendri, Felix (49 |
57200655152; 57200649149; 57201675676; 57192909801; 59195385200; 36848942500; 57201668200; 57201669352; 45561124000; 59196009500; 55363079700; 7103172058; 8542765200; 35479237300; 49965161300 |
Chemical Composition and Neuroprotective Properties of Indonesian Stingless Bee (Geniotrigona thoracica) Propolis Extract in an In-Vivo Model of Intracerebral Hemorrhage (ICH) |
2024 |
Nutrients |
16 |
12 |
|
|
|
|
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85197176112&doi=10.3390%2fnu16121880&partnerID=40&md5=c2b0f17a5747aa84f10408453a771fc6 |
Philosophy Doctor in Medicine Programme, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20155, Indonesia; Department of Neurosurgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20155, Indonesia; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20155, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20155, Indonesia; Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, 10430, Jakarta, Indonesia; Department of Psychiatry, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20155, Indonesia; Department of Community and Preventive Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20155, Indonesia; Undergraduate Program in Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20155, Indonesia; Physiology Division, Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Kabupaten Sumedang, 45363, West Java, Indonesia; Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria; Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Kabupaten Sumedang, Jawa Barat 45363, Indonesia; Kebun Efi, Kabupaten Karo, Sumatera Utara 22171, Indonesia |
Tandean S., Philosophy Doctor in Medicine Programme, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20155, Indonesia, Department of Neurosurgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20155, Indonesia; Japardi I., Philosophy Doctor in Medicine Programme, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20155, Indonesia; Rusda M., Philosophy Doctor in Medicine Programme, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20155, Indonesia, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20155, Indonesia; Indharty R.S., Philosophy Doctor in Medicine Programme, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20155, Indonesia, Department of Neurosurgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20155, Indonesia; Lelo A., Philosophy Doctor in Medicine Programme, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20155, Indonesia, Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20155, Indonesia; Aman R.A., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, 10430, Jakarta, Indonesia; Amin M.M., Philosophy Doctor in Medicine Programme, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20155, Indonesia, Department of Psychiatry, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20155, Indonesia; Siahaan A.M.P., Philosophy Doctor in Medicine Programme, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20155, Indonesia, Department of Neurosurgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20155, Indonesia; Eyanoer P.C., Philosophy Doctor in Medicine Programme, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20155, Indonesia, Department of Community and Preventive Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20155, Indonesia; D'Prinzessin C.A., Undergraduate Program in Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20155, Indonesia; Lesmana R., Physiology Division, Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Kabupaten Sumedang, 45363, West Java, Indonesia; Popova M., Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria; Trusheva B., Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria; Bankova V., Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria; Zulhendri F., Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Kabupaten Sumedang, Jawa Barat 45363, Indonesia, Kebun Efi, Kabupaten Karo, Sumatera Utara 22171, Indonesia |
Stroke is the world's second-leading cause of death. Current treatments for cerebral edema following intracerebral hemorrhage (ICH) mainly involve hyperosmolar fluids, but this approach is often inadequate. Propolis, known for its various beneficial properties, especially antioxidant and anti-inflammatory properties, could potentially act as an adjunctive therapy and help alleviate stroke-associated injuries. The chemical composition of Geniotrigona thoracica propolis extract was analyzed by GC-MS after derivatization for its total phenolic and total flavonoid content. The total phenolic content and total flavonoid content of the propolis extract were 1037.31 ± 24.10 μg GAE/mL and 374.02 ± 3.36 μg QE/mL, respectively. By GC-MS analysis, its major constituents were found to be triterpenoids (22.4% of TIC). Minor compounds, such as phenolic lipids (6.7% of TIC, GC-MS) and diterpenic acids (2.3% of TIC, GC-MS), were also found. Ninety-six Sprague Dawley rats were divided into six groups; namely, the control group, the ICH group, and four ICH groups that received the following therapies: mannitol, propolis extract (daily oral propolis administration after the ICH induction), propolis-M (propolis and mannitol), and propolis-B+A (daily oral propolis administration 7 days prior to and 72 h after the ICH induction). Neurocognitive functions of the rats were analyzed using the rotarod challenge and Morris water maze. In addition, the expression of NF-κB, SUR1-TRPM4, MMP-9, and Aquaporin-4 was analyzed using immunohistochemical methods. A TUNEL assay was used to assess the percentage of apoptotic cells. Mannitol significantly improved cognitive-motor functions in the ICH group, evidenced by improved rotarod and Morris water maze completion times, and lowered SUR-1 and Aquaporin-4 levels. It also significantly decreased cerebral edema by day 3. Similarly, propolis treatments (propolis-A and propolis-B+A) showed comparable improvements in these tests and reduced edema. Moreover, combining propolis with mannitol (propolis-M) further enhanced these effects, particularly in reducing edema and the Virchow-Robin space. These findings highlight the potential of propolis from the Indonesian stingless bee, Geniotrigona thoracica, from the Central Tapanuli region as a neuroprotective, adjunctive therapy. |
functional food; intracerebral hemorrhage; neuro-protective; propolis; stroke |
Animals; Antioxidants; Bees; Brain Edema; Cerebral Hemorrhage; Disease Models, Animal; Flavonoids; Gas Chromatography-Mass Spectrometry; Male; Neuroprotective Agents; Phenols; Propolis; Rats; Rats, Sprague-Dawley; antioxidant; flavonoid; neuroprotective agent; phenol derivative; propolis; animal; bee; brain edema; brain hemorrhage; chemistry; disease model; drug therapy; male; mass fragmentography; rat; Sprague Dawley rat |
|
|
|
20726643 |
|
38931235 |
Article |
Q1 |
1291 |
2754 |
|
|
|
140 |
Nurkolis F.; Visnu J.; Sabrina N.; Hardinsyah H.; Taslim N.A.; Gunawan W.B.; Tanner M.J.; Mayulu N.; Khumaidi M.A.; Syahputra R.A.; Rizal M.; Tjandrawinata R.R.; Tallei T.E.; Basrowi R.W.; Sundjaya T.; Serra-Majem L. |
Nurkolis, Fahrul (57226728465); Visnu, Jodi (57821546400); Sabrina, Nindy (57195308261); Hardinsyah, Hardinsyah (56586054400); Taslim, Nurpudji Astuti (57194571794); Gunawan, William Ben (57722976700); Tanner, Melvin Junior (57665191700); Mayulu, Nelly (57303104200); Khumaidi, Mohammad Adib (57328108800); Syahputra, Rony Abdi (57216124200); Rizal, Mochammad (57209853238); Tjandrawinata, Raymond Rubianto (6603266135); Tallei, Trina Ekawati (57193317686); Basrowi, Ray Wagiu (57024210400); Sundjaya |
57226728465; 57821546400; 57195308261; 56586054400; 57194571794; 57722976700; 57665191700; 57303104200; 57328108800; 57216124200; 57209853238; 6603266135; 57193317686; 57024210400; 57188810826; 35596972100 |
The Importance of Philanthropy Foundation for the Future Sustainability of Agriculture and Nutrition: An Opinion Study on Practical Applications, Policies, and Strategies |
2024 |
Nutrients |
16 |
8 |
|
|
|
|
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85191633464&doi=10.3390%2fnu16081119&partnerID=40&md5=503c28e907fb0dc3f7d85279a8eeecad |
Department of Biological Sciences, Faculty of Sciences and Technology, State Islamic University of Sunan Kalijaga, 55281, Yogyakarta, Indonesia; Public Health Consultant and Health Educator, Panti Rapih Hospital, Marketing Strategy Consultant and Hospital Representative, Yogyakarta 55223, Indonesia; Center for Health Policy and Management, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, 55281, Yogyakarta, Indonesia; Nutrition Program, Faculty of Food Technology and Health, Sahid University of Jakarta, South Jakarta 12870, Indonesia; Applied Nutrition Division, Department of Community Nutrition, Faculty of Human Ecology, IPB University, Bogor, 16680, Indonesia; Clinical Nutrition, Faculty of Medicine, Hasanuddin University, Makassar, 90245, Indonesia; Department of Nutrition Science, Faculty of Medicine, Diponegoro University, Semarang, 50275, Indonesia; Nutrition Coaching Development, 12430, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Muhammadiyah Manado, Manado 95249, Indonesia; Faculty of Medicine and Health, Universitas Muhammadiyah Jakarta, 15419, Jakarta, Indonesia; Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia; Division of Nutritional Sciences, Cornell University, Ithaca, NY 14850, USA; Dexa Laboratories of Biomolecular Science, Dexa Medica Group, Cikarang, 17530, Indonesia; Department of Biotechnology, Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, 12930, Jakarta, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sam Ratulangi, Manado, 95115, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, 10320, Jakarta, Indonesia; Danone Specialized Nutrition, 12940, Jakarta, Indonesia; Department of Epidemiology, Faculty of Public Health, Universitas Indonesia, 16424, Jakarta, Indonesia; Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, 28029, Madrid, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Las Palmas, 35001, Spain |
Nurkolis F., Department of Biological Sciences, Faculty of Sciences and Technology, State Islamic University of Sunan Kalijaga, 55281, Yogyakarta, Indonesia; Visnu J., Public Health Consultant and Health Educator, Panti Rapih Hospital, Marketing Strategy Consultant and Hospital Representative, Yogyakarta 55223, Indonesia, Center for Health Policy and Management, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, 55281, Yogyakarta, Indonesia; Sabrina N., Nutrition Program, Faculty of Food Technology and Health, Sahid University of Jakarta, South Jakarta 12870, Indonesia; Hardinsyah H., Applied Nutrition Division, Department of Community Nutrition, Faculty of Human Ecology, IPB University, Bogor, 16680, Indonesia; Taslim N.A., Clinical Nutrition, Faculty of Medicine, Hasanuddin University, Makassar, 90245, Indonesia; Gunawan W.B., Department of Nutrition Science, Faculty of Medicine, Diponegoro University, Semarang, 50275, Indonesia; Tanner M.J., Nutrition Coaching Development, 12430, Jakarta, Indonesia; Mayulu N., Department of Nutrition, Faculty of Medicine, Universitas Muhammadiyah Manado, Manado 95249, Indonesia; Khumaidi M.A., Faculty of Medicine and Health, Universitas Muhammadiyah Jakarta, 15419, Jakarta, Indonesia; Syahputra R.A., Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia; Rizal M., Division of Nutritional Sciences, Cornell University, Ithaca, NY 14850, USA; Tjandrawinata R.R., Dexa Laboratories of Biomolecular Science, Dexa Medica Group, Cikarang, 17530, Indonesia, Department of Biotechnology, Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, 12930, Jakarta, Indonesia; Tallei T.E., Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sam Ratulangi, Manado, 95115, Indonesia; Basrowi R.W., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, 10320, Jakarta, Indonesia, Danone Specialized Nutrition, 12940, Jakarta, Indonesia; Sundjaya T., Danone Specialized Nutrition, 12940, Jakarta, Indonesia, Department of Epidemiology, Faculty of Public Health, Universitas Indonesia, 16424, Jakarta, Indonesia; Serra-Majem L., Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, 28029, Madrid, Spain, Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Las Palmas, 35001, Spain |
Food security, food sustainability, and malnutrition represent critical global challenges. Th urgency of comprehensive action is evident in the need for research collaboration between the food industry, agriculture, public health, and nutrition. This article highlights the role of philanthropy, of a non-profit organization, in supporting research and development and filling financial gaps. The article also explores the interplay of nutrition, agriculture, and government and policy, positioning philanthropy as a catalyst for transformative change and advocating for collaborative efforts to comprehensively address global food challenges. In addition, the discussion also underscores the ethical complexities surrounding charitable food aid, especially in terms of the dignity and autonomy of its recipients. The paper concludes by proposing future directions and implications, advocating for diversified intervention portfolios and collaborative efforts involving governments, businesses, and local communities. Apart from that, the importance of answering and alleviating ethical dilemmas related to food charity assistance needs to be a concern for future studies related to philanthropy because of the significant challenges faced by the contemporary food system, which include food security, health, and nutritional sustainability. |
climate action; food charity; foundation; future foods; nutrition and sustainable development; philanthropy; sustainability; sustainable agriculture and nutrition |
Agriculture; Charities; Food Assistance; Food Security; Food Supply; Fund Raising; Humans; Nutrition Policy; agriculture; catering service; ethics; financial management; food assistance; food security; human; nutrition policy; social welfare |
|
|
|
20726643 |
|
38674810 |
Article |
Q1 |
1291 |
2754 |
|
|
|
145 |
Widodo D.W.; Zizlavsky S. |
Widodo, Dini Widiarni (56644646600); Zizlavsky, Semiramis (57195721920) |
56644646600; 57195721920 |
Correlation of Grading and Number of Ear Subunits With Auditory Brainstem Response Findings in Children With Microtia |
2024 |
American journal of audiology |
33 |
2 |
|
503 |
509 |
6 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85195228893&doi=10.1044%2f2024_AJA-23-00162&partnerID=40&md5=eb3bc6e67c83e792538fd55464696ebd |
Department of Ear Nose Throat-Head Neck Surgery, Faculty of Medicine, University of Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Widodo D.W., Department of Ear Nose Throat-Head Neck Surgery, Faculty of Medicine, University of Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Zizlavsky S., Department of Ear Nose Throat-Head Neck Surgery, Faculty of Medicine, University of Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
PURPOSE: The association between microtia severity and hearing function has been thoroughly investigated. This study examined the relationship between microtia grade, number of ear subunits (i.e., helix, antihelix, scapha, triangularis fossa, concha, lobule, tragus, and antitragus) with auditory brainstem response (ABR) findings in children with microtia. STUDY DESIGN: A retrospective chart review was employed in this study. METHOD: We analyzed the ABR test results and photographs of 22 children with 30 microtia ears at Dr. Cipto Mangunkusumo National Hospital, Jakarta. The ABR test results were acquired using click (air conduction only) and 500-Hz tone burst stimuli (air- and bone-conduction). Ear photographs were overlaid with a template of a normal ear to determine the number of ear subunits present and the subsequent microtia grade. Number of ear subunits and ABR results were analyzed using the chi-square, Mann-Whitney U, and Spearman's correlation tests. RESULTS: ABR thresholds for click and 500-Hz tone bursts air-conduction were significantly poorer for ears with a subunit < 5 compared to ears with a subunit ≥ 5. No significant difference was observed in 500 Hz bone-conduction ABR thresholds between these groups. Correlation analysis showed a significant negative correlation between increased ear subunits and click ABR thresholds. No significant correlation was found between ear subunits and 500-Hz air- and bone-conduction ABR thresholds. CONCLUSIONS: A higher number of ear subunits are associated with a lower hearing threshold, as assessed using ABR with click stimuli. Therefore, the number of ear subunits and microtia grades can be used to examine the hearing level thresholds in infants and children with microtia. SUPPLEMENTAL MATERIAL: https://doi.org/10.23641/asha.25669440. |
|
Adolescent; Auditory Threshold; Child; Child, Preschool; Congenital Microtia; Ear; Evoked Potentials, Auditory, Brain Stem; Female; Humans; Male; Retrospective Studies; Severity of Illness Index; adolescent; auditory threshold; child; ear; evoked brain stem auditory response; female; human; male; microtia; pathophysiology; physiology; preschool child; retrospective study; severity of illness index |
|
|
|
15589137 |
|
38668691 |
Article |
Q2 |
677 |
7414 |
|
|
|
146 |
Pratama G.; Wiweko B.; Asmarinah; Widyahening I.S.; Andraini T.; Bayuaji H.; Hestiantoro A. |
Pratama, Gita (58162878900); Wiweko, Budi (43061741400); Asmarinah (15820317600); Widyahening, Indah S. (54893154400); Andraini, Trinovita (57192868276); Bayuaji, Hartanto (57202002345); Hestiantoro, Andon (8743255100) |
58162878900; 43061741400; 15820317600; 54893154400; 57192868276; 57202002345; 8743255100 |
Mechanism of elevated LH/FSH ratio in lean PCOS revisited: a path analysis |
2024 |
Scientific reports |
14 |
1 |
|
8229 |
|
|
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85190353467&doi=10.1038%2fs41598-024-58064-0&partnerID=40&md5=3c99346ba22b8f28999f83ef6c96bf14 |
Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Cluster of Human Reproduction, Infertility and Family Planning, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Medical Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Physiology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Padjadjaran, Bandung, Indonesia |
Pratama G., Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Cluster of Human Reproduction, Infertility and Family Planning, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Wiweko B., Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Cluster of Human Reproduction, Infertility and Family Planning, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Asmarinah, Department of Medical Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Widyahening I.S., Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Andraini T., Department of Physiology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Bayuaji H., Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Padjadjaran, Bandung, Indonesia; Hestiantoro A., Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Cluster of Human Reproduction, Infertility and Family Planning, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting 5-20% of reproductive-age women. However, the treatment of PCOS is mainly based on symptoms and not on its pathophysiology. Neuroendocrine disturbance, as shown by an elevated LH/FSH ratio in PCOS patients, was thought to be the central mechanism of the syndrome, especially in lean PCOS. LH and FSH secretion are influenced by GnRH pulsatility of GnRH neurons in the hypothalamus. Kisspeptin is the main regulator of GnRH secretion, whereas neurokinin B (NKB) and dynorphin regulate kisspeptin secretion in KNDy neurons. This study aims to deepen the understanding of the neuroendocrine disorder in lean PCOS patients and its potential pathophysiology-based therapy. A cross-sectional study was performed at Dr. Cipto Mangunkusumo Kencana Hospital and the IMERI UI HRIFP cluster with 110 lean PCOS patients as subjects. LH, FSH, LH/FSH ratio, kisspeptin, NKB, dynorphin, leptin, adiponectin, AMH, fasting blood glucose, fasting insulin, HOMA-IR, testosterone, and SHBG were measured. Bivariate and path analyses were performed to determine the relationship between variables. There was a negative association between dynorphin and kisspeptin, while NKB levels were not associated with kisspeptin. There was no direct association between kisspeptin and the LH/FSH ratio; interestingly, dynorphin was positively associated with the LH/FSH ratio in both bivariate and pathway analyses. AMH was positively correlated with the LH/FSH ratio in both analyses. Path analysis showed an association between dynorphin and kisspeptin levels in lean PCOS, while NKB was not correlated with kisspeptin. Furthermore, there was a correlation between AMH and the LH/FSH ratio, but kisspeptin levels did not show a direct significant relationship with the LH/FSH ratio. HOMA-IR was negatively associated with adiponectin levels and positively associated with leptin and FAI levels. In conclusion, AMH positively correlates with FAI levels and is directly associated with the LH/FSH ratio, showing its important role in neuroendocrinology in lean PCOS. From the path analysis, AMH was also an intermediary variable between HOMA-IR and FAI with the LH/FSH ratio. Interestingly, this study found a direct positive correlation between dynorphin and the LH/FSH ratio, while no association between kisspeptin and the LH/FSH ratio was found. Further research is needed to investigate AMH and dynorphin as potential therapeutic targets in the management of lean PCOS patients. © 2024. The Author(s). |
AMH; Dynorphin; FAI; HOMA-IR; Kisspeptin; Lean; LH/FSH ratio; Neurokinin B; PCOS |
Adiponectin; Cross-Sectional Studies; Dynorphins; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Humans; Kisspeptins; Leptin; Luteinizing Hormone; Neurokinin B; Polycystic Ovary Syndrome; adiponectin; dynorphin; follitropin; gonadorelin; kisspeptin; leptin; luteinizing hormone; neurokinin B; cross-sectional study; female; human; metabolism; ovary polycystic disease |
|
|
|
20452322 |
|
38589425 |
Article |
Q1 |
973 |
4401 |
|
|
|
164 |
Yasnova N.; Sirait S.P.; Rahmayunita G. |
Yasnova, Nevi (58085450500); Sirait, Sondang P. (56426927400); Rahmayunita, Githa (57192909174) |
58085450500; 56426927400; 57192909174 |
The effectiveness and safety of 3% tranexamic acid cream vs. 4% hydroquinone cream for mixed-type melasma in skin of color: a double-blind, split-face, randomized controlled trial |
2024 |
Acta dermatovenerologica Alpina, Pannonica, et Adriatica |
33 |
2 |
|
83 |
88 |
5 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85197059985&partnerID=40&md5=f2bf707359afcfb09c6150b95885fe6b |
Department of Dermatology and Venereology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Yasnova N., Department of Dermatology and Venereology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Sirait S.P., Department of Dermatology and Venereology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Rahmayunita G., Department of Dermatology and Venereology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
INTRODUCTION: Melasma, a chronic acquired skin pigmentation disorder, is characterized by the presence of irregular-edged brown to gray-brown patches with a symmetrical distribution, primarily on sun-exposed areas such as the face. Topical hydroquinone (HQ) is the gold standard for melasma treatment but has numerous side effects. This study assesses the effectiveness of topical tranexamic acid (TA) as an alternative for melasma treatment. METHODS: In a double-blind, split-face, randomized controlled trial involving 20 subjects, the effectiveness of 3% TA versus 4% HQ cream was evaluated over 8 weeks. The modified melasma area and severity index (mMASI), melanin index, erythema index, and side effects were assessed. Subjective improvement was measured using the patient global assessment (PtGA). RESULTS: A significant decline in the mMASI score was observed at weeks 4 and 8 in both groups compared to baseline. There were no statistically significant differences in PtGA scores between the 3% TA group and the 4% HQ group. CONCLUSIONS: Topical 3% TA is as effective and safe as 4% HQ for treating melasma in the Indonesian population, with potential advantages in terms of side-effect profiles. |
|
Administration, Cutaneous; Adult; Double-Blind Method; Female; Humans; Hydroquinones; Male; Melanosis; Middle Aged; Severity of Illness Index; Skin Cream; Skin Pigmentation; Tranexamic Acid; Treatment Outcome; hydroquinone; hydroquinone derivative; skin cream; tranexamic acid; adult; comparative study; controlled study; cutaneous drug administration; double blind procedure; drug effect; drug therapy; female; human; male; melanosis; middle aged; randomized controlled trial; severity of illness index; skin pigmentation; treatment outcome |
|
|
|
15812979 |
|
38918942 |
Article |
#N/A |
#N/A |
#N/A |
|
|
|
166 |
Permatasari H.K.; Abshori N.F.; Syahputra R.A.; Harahap U.; Amalia N.; Kumalawati D.A.; Mayulu N.; Taslim N.A.; Tallei T.E.; Tjandrawinata R.R.; Wiyarta E.; Pramono A.; Kim B.; Tsopmo A.; Serra-Majem L.; Nurkolis F. |
Permatasari, Happy Kurnia (57194728338); Abshori, Nuril Farid (59144943300); Syahputra, Rony Abdi (57216124200); Harahap, Urip (55656293200); Amalia, Nurlinah (58315596900); Kumalawati, Dian Aruni (36721370800); Mayulu, Nelly (57303104200); Taslim, Nurpudji Astuti (57194571794); Tallei, Trina Ekawati (57193317686); Tjandrawinata, Raymond Rubianto (6603266135); Wiyarta, Elvan (57221521342); Pramono, Adriyan (56825779200); Kim, Bonglee (51663469700); Tsopmo, Apollinaire (6602260089); Serra-Majem, |
57194728338; 59144943300; 57216124200; 55656293200; 58315596900; 36721370800; 57303104200; 57194571794; 57193317686; 6603266135; 57221521342; 56825779200; 51663469700; 6602260089; 35596972100; 57226728465 |
Novel Functional Food Properties of Forest Onion (Eleutherine bulbosa Merr.) Phytochemicals for Treating Metabolic Syndrome: New Insights from a Combined Computational and In Vitro Approach |
2024 |
Nutrients |
16 |
10 |
|
|
|
|
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85194219741&doi=10.3390%2fnu16101441&partnerID=40&md5=263cd6110a09906cb804a5055e32ae8e |
Department of Biochemistry and Biomolecular, Faculty of Medicine, University of Brawijaya, Malang, 65145, Indonesia; Medical Study Program, Faculty of Medicine, State Islamic University of Maulana Malik Ibrahim (UIN Maulana Malik Ibrahim), Malang, 65144, Indonesia; Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia; Master Program of Biomedical Science, Faculty of Medicine, Brawijaya University, Malang, 65151, Indonesia; Department of Biological Sciences, Faculty of Sciences and Technology, State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga), 55281, Yogyakarta, Indonesia; Department of Nutrition, Faculty of Health Science, Muhammadiyah Manado University, Manado 95249, Indonesia; Division of Clinical Nutrition, Department of Nutrition, Faculty of Medicine, Hasanuddin University, Makassar, 90245, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, 95115, Indonesia; Department of Biotechnology, Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, 12930, Jakarta, Indonesia; Department of Neurology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Hospital, 10430, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine, Diponegoro University, Semarang, 50275, Indonesia; Center of Nutrition Research (CENURE), Diponegoro University, Semarang, 50275, Indonesia; Department of Pathology, College of Korean Medicine, Kyung Hee University, 02447, Seoul, South Korea; Food Science Program, Department of Chemistry, Institute of Biochemistry, Carleton University, 1125 Colonel by Drive, Ottawa, ON K1S 5B6, Canada; Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, 28029, Madrid, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Las Palmas, 35001, Spain |
Permatasari H.K., Department of Biochemistry and Biomolecular, Faculty of Medicine, University of Brawijaya, Malang, 65145, Indonesia; Abshori N.F., Medical Study Program, Faculty of Medicine, State Islamic University of Maulana Malik Ibrahim (UIN Maulana Malik Ibrahim), Malang, 65144, Indonesia; Syahputra R.A., Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia; Harahap U., Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia; Amalia N., Master Program of Biomedical Science, Faculty of Medicine, Brawijaya University, Malang, 65151, Indonesia; Kumalawati D.A., Department of Biological Sciences, Faculty of Sciences and Technology, State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga), 55281, Yogyakarta, Indonesia; Mayulu N., Department of Nutrition, Faculty of Health Science, Muhammadiyah Manado University, Manado 95249, Indonesia; Taslim N.A., Division of Clinical Nutrition, Department of Nutrition, Faculty of Medicine, Hasanuddin University, Makassar, 90245, Indonesia; Tallei T.E., Department of Biology, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, 95115, Indonesia; Tjandrawinata R.R., Department of Biotechnology, Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, 12930, Jakarta, Indonesia; Wiyarta E., Department of Neurology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Hospital, 10430, Jakarta, Indonesia; Pramono A., Department of Nutrition, Faculty of Medicine, Diponegoro University, Semarang, 50275, Indonesia, Center of Nutrition Research (CENURE), Diponegoro University, Semarang, 50275, Indonesia; Kim B., Department of Pathology, College of Korean Medicine, Kyung Hee University, 02447, Seoul, South Korea; Tsopmo A., Food Science Program, Department of Chemistry, Institute of Biochemistry, Carleton University, 1125 Colonel by Drive, Ottawa, ON K1S 5B6, Canada; Serra-Majem L., Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, 28029, Madrid, Spain, Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Las Palmas, 35001, Spain; Nurkolis F., Department of Biological Sciences, Faculty of Sciences and Technology, State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga), 55281, Yogyakarta, Indonesia |
Metabolic syndrome is a global health problem. The use of functional foods as dietary components has been increasing. One food of interest is forest onion extract (FOE). This study aimed to investigate the effect of FOE on lipid and glucose metabolism in silico and in vitro using the 3T3-L1 mouse cell line. This was a comprehensive study that used a multi-modal computational network pharmacology analysis and molecular docking in silico and 3T3-L1 mouse cells in vitro. The phytochemical components of FOE were analyzed using untargeted ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS). Next, an in silico analysis was performed to determine FOE's bioactive compounds, and a toxicity analysis, protein target identification, network pharmacology, and molecular docking were carried out. FOE's effect on pancreatic lipase, α-glucosidase, and α-amylase inhibition was determined. Finally, we determined its effect on lipid accumulation and MAPK8, PPARG, HMGCR, CPT-1, and GLP1 expression in the preadipocyte 3T3-L1 mouse cell line. We showed that the potential metabolites targeted glucose and lipid metabolism in silico and that FOE inhibited pancreatic lipase levels, α-glucosidase, and α-amylase in vitro. Furthermore, FOE significantly (p < 0.05) inhibits targeted protein expressions of MAPK8, PPARG, HMGCR, CPT-1, and GLP-1 in vitro in 3T3-L1 mouse cells in a dose-dependent manner. FOE contains several metabolites that reduce pancreatic lipase levels, α-glucosidase, α-amylase, and targeted proteins associated with lipid and glucose metabolism in vitro. |
diabetes; forest onion; functional food; metabolic syndrome; mouse cell line; network pharmacology; obesity; phytochemicals; preadipocyte 3T3-L1 |
3T3-L1 Cells; alpha-Amylases; alpha-Glucosidases; Animals; Computer Simulation; Functional Food; Glucose; Lipase; Lipid Metabolism; Metabolic Syndrome; Mice; Molecular Docking Simulation; Network Pharmacology; Onions; Phytochemicals; Plant Extracts; PPAR gamma; Tandem Mass Spectrometry; alpha glucosidase; amylase; glucose; peroxisome proliferator activated receptor gamma; phytochemical; plant extract; triacylglycerol lipase; 3T3-L1 cell line; animal; chemistry; computer simulation; drug effect; drug therapy; functional food; lipid metabolism; metabolic syndrome X; metabolism; molecular docking; mouse; onion; systems pharmacology; tandem mass spectrometry |
|
|
|
20726643 |
|
38794679 |
Article |
Q1 |
1291 |
2754 |
|
|
|
195 |
Santosa K.B.; Marta S.N.; Sugianto R.; Widia F.; Nababan P.; Rahardjp H.E. |
Santosa, Kadek Budi (57205260815); Marta, Stacia Novia (57218364423); Sugianto, Ronald (57226634392); Widia, Fina (26028200800); Nababan, Parsaoran (59196256200); Rahardjp, Harrina Erlianti (59195421200) |
57205260815; 57218364423; 57226634392; 26028200800; 59196256200; 59195421200 |
Surgeon's point of view in vesico-vaginal fistula management |
2024 |
Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica |
96 |
2 |
|
12450 |
|
|
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85197160790&doi=10.4081%2faiua.2024.12450&partnerID=40&md5=5194ca4589e3b5ea8bc77e87eaaadc74 |
Department of Urology, Faculty of Medicine, Universitas Udayana; Prof. Dr. I.G.N.G Ngoerah General Hospital, Denpasar. busanbsa@gmail.com; Prof. Dr. I.G.N.G Ngoerah General Hospital, Denpasar; Department of Surgery, Faculty of Medicine, Universitas Udayana; Prof. Dr. I.G.N.G Ngoerah General Hospital, Denpasar; Department of Urology, Faculty of Medicine, Universitas Airlangga; Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Urology, Bhayangkara Anton Soedjarwo Hospital, Pontianak, Indonesia; Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Santosa K.B., Department of Urology, Faculty of Medicine, Universitas Udayana; Prof. Dr. I.G.N.G Ngoerah General Hospital, Denpasar. busanbsa@gmail.com; Marta S.N., Prof. Dr. I.G.N.G Ngoerah General Hospital, Denpasar; Department of Surgery, Faculty of Medicine, Universitas Udayana; Sugianto R., Prof. Dr. I.G.N.G Ngoerah General Hospital, Denpasar; Department of Urology, Faculty of Medicine, Universitas Airlangga; Widia F., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Nababan P., Department of Urology, Bhayangkara Anton Soedjarwo Hospital, Pontianak, Indonesia; Rahardjp H.E., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
OBJECTIVES: Vesicovaginal fistulas (VVF) are the most commonly acquired fistulas of the urinary tract. The management of VVF is mainly based on expert opinion and surgeon experience. This study aims to provide the practice patterns and outcomes of vesicovaginal fistula (VVF) management in Indonesia. METHODS: This study utilizes the results of a survey among the surgeons who performs VVF repair in referral hospitals throughout Indonesia between June and July of 2021. Data analysis was carried out with SPSS descriptively by displaying the relative frequency of the answers to each question of the questionnaire form. RESULTS: We collected responses from 93 respondents consisting of 68 urologists and 25 gynecologists. The most commonly reported cause of VVF was obstetric (50.5%). Most respondents confirmed the diagnosis of VVF by cystoscopy (81.7%). Waiting time to repair VVF was generally 12 weeks (79.6%), while the transvaginal approach repair was more often performed (77.4%). An additional procedure, such as tissue interposition was performed in 50.5% of cases. Tissue interposition was mostly indicated in recurrent VVF (81%), with omentum being the most selected tissue interposition (71%). When indicated, the most selected method of transabdominal approach was open transvesical (54,84%). A laparoscopic approach was performed only in 7.5% of cases. Overall, the success rate for VVF repair in Indonesia was 70-100% at first attempt. CONCLUSIONS: The transvaginal approach is preferred, either with or without an interposition tissue flap. The success rate at the first attempt is satisfactory. |
|
Adult; Female; Gynecologic Surgical Procedures; Gynecology; Humans; Indonesia; Practice Patterns, Physicians'; Surveys and Questionnaires; Treatment Outcome; Urologic Surgical Procedures; Vesicovaginal Fistula; adult; clinical practice; cystovaginal fistula; female; gynecologic surgery; gynecology; human; Indonesia; procedures; questionnaire; surgery; treatment outcome; urologic surgery |
|
|
|
22824197 |
|
38934525 |
Article |
#N/A |
#N/A |
#N/A |
|
|
