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Siregar G.O.; Harianja M.; Adella J.; Krismawati H.; Sundari E.S.; Ataupah M.R.; Laiskodat R.D.; Bøgh C.; Soebono H.; Grijsen M.L. |
Siregar, Gladys O. (58876649500); Harianja, Maria (58876435800); Adella, Jacklyn (58994793100); Krismawati, Hana (56572770100); Sundari, Evivana S. (58876435900); Ataupah, Messe R. (58993911900); Laiskodat, Ruth D. (58994354700); Bøgh, Claus (6602120205); Soebono, Hardyanto (6508242918); Grijsen, Marlous L. (25225113700) |
58876649500; 58876435800; 58994793100; 56572770100; 58876435900; 58993911900; 58994354700; 6602120205; 6508242918; 25225113700 |
Leprosy identified in Sumba Island, eastern Indonesia: elimination targets under threat |
2024 |
The Lancet Regional Health - Southeast Asia |
26 |
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100409 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85190856063&doi=10.1016%2fj.lansea.2024.100409&partnerID=40&md5=4f24b635df4260f90f0d5f674d9efa33 |
Sumba Foundation, Sumba, Indonesia; Center of Health System and Strategy, Ministry of Health, Jakarta, Indonesia; Department of Dermatology and Venereology, Siloam Hospital, Kupang, Indonesia; Province Health Office, East Nusa Tenggara, Kupang, Indonesia; Department of Dermatology and Venereology, Gadjah Mada University, Yogyakarta, Indonesia; Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, United Kingdom |
Siregar G.O., Sumba Foundation, Sumba, Indonesia; Harianja M., Sumba Foundation, Sumba, Indonesia; Adella J., Sumba Foundation, Sumba, Indonesia; Krismawati H., Center of Health System and Strategy, Ministry of Health, Jakarta, Indonesia; Sundari E.S., Department of Dermatology and Venereology, Siloam Hospital, Kupang, Indonesia; Ataupah M.R., Province Health Office, East Nusa Tenggara, Kupang, Indonesia; Laiskodat R.D., Province Health Office, East Nusa Tenggara, Kupang, Indonesia; Bøgh C., Sumba Foundation, Sumba, Indonesia; Soebono H., Department of Dermatology and Venereology, Gadjah Mada University, Yogyakarta, Indonesia; Grijsen M.L., Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, United Kingdom |
[No abstract available] |
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awareness; disease burden; disease transmission; health care personnel; human; leprosy; multibacillary leprosy; nerve injury; Note; paucibacillary leprosy; polypharmacy; primary health care; skin care; teledermatology; telemedicine |
Wellcome Trust, WT; Sumba Foundation |
Funding text 1: The project was financially supported by the Wellcome Trust Africa Asia Programme Vietnam. The authors declare that they have no conflicts of interest. ; Funding text 2: We extend our sincere gratitude to all Sumba Foundation healthcare workers. We wish to acknowledge Ben Naafs for sharing his expertise on leprosy with the clinical team. |
Elsevier Ltd |
27723682 |
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46 |
Gach M.W.; Lazarus G.; Simadibrata D.M.; Sinto R.; Saharman Y.R.; Limato R.; Nelwan E.J.; van Doorn H.R.; Karuniawati A.; Hamers R.L. |
Gach, Michael W. (57675752100); Lazarus, Gilbert (57214599425); Simadibrata, Daniel Martin (57202134322); Sinto, Robert (36099377100); Saharman, Yulia Rosa (55980934300); Limato, Ralalicia (57196224631); Nelwan, Erni J. (14527452900); van Doorn, H. Rogier (56941604800); Karuniawati, Anis (54886816200); Hamers, Raph L. (23034345900) |
57675752100; 57214599425; 57202134322; 36099377100; 55980934300; 57196224631; 14527452900; 56941604800; 54886816200; 23034345900 |
Antimicrobial resistance among common bacterial pathogens in Indonesia: a systematic review |
2024 |
The Lancet Regional Health - Southeast Asia |
26 |
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100414 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85192810137&doi=10.1016%2fj.lansea.2024.100414&partnerID=40&md5=8b7941694224b5ac273f8fd664e75b48 |
Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Department of Internal Medicine, Division of Tropical Medicine and Infectious Diseases, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Clinical Microbiology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Oxford University Clinical Research Unit, Hanoi, Viet Nam |
Gach M.W., Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Lazarus G., Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Simadibrata D.M., Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States; Sinto R., Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Department of Internal Medicine, Division of Tropical Medicine and Infectious Diseases, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Saharman Y.R., Department of Clinical Microbiology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Limato R., Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Nelwan E.J., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Internal Medicine, Division of Tropical Medicine and Infectious Diseases, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; van Doorn H.R., Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Oxford University Clinical Research Unit, Hanoi, Viet Nam; Karuniawati A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Clinical Microbiology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Hamers R.L., Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom |
Background: The WHO Global Antimicrobial Resistance Surveillance System (GLASS) aims to describe antimicrobial resistance (AMR) patterns and trends in common bacterial pathogens, but data remain limited in many low and middle-income countries including Indonesia. Methods: We systematically searched Embase, PubMed and Global Health Database and three Indonesian databases for original peer-reviewed articles in English and Indonesian, published between January 1, 2000 and May 25, 2023, that reported antimicrobial susceptibility for the 12 GLASS target pathogens from human samples. Pooled AMR prevalence estimates were calculated for relevant pathogen-antimicrobial combinations accounting for the sampling weights of the studies (PROSPERO: CRD42019155379). Findings: Of 2182 search hits, we included 102 papers, comprising 19,517 bacterial isolates from hospitals (13,647) and communities (5870). In hospital settings, 21.6% of Klebsiella pneumoniae isolates, 18.3% of Escherichia coli isolates, 35.8% of Pseudomonas aeruginosa isolates and 70.7% of Acinetobacter baumannii isolates were carbapenem-resistant; 29.9% of Streptococcus pneumoniae isolates were penicillin-resistant; and 22.2% of Staphylococcus aureus isolates were methicillin-resistant. Hospital prevalence of carbapenem-resistant K. pneumoniae and E. coli, and penicillin-resistant S. pneumoniae increased over time. In communities, 28.3% of K. pneumoniae isolates and 15.7% of E. coli isolates were carbapenem-resistant, 23.9% of S. pneumoniae isolates were penicillin-resistant, and 11.1% of S. aureus isolates were methicillin-resistant. Data were limited for the other pathogens. Interpretation: AMR prevalence estimates were high for critical gram-negative bacteria. However, data were insufficient to draw robust conclusions about the full contemporary AMR situation in Indonesia. Implementation of national AMR surveillance is a priority to address these gaps and inform context-specific interventions. Funding: Wellcome Africa Asia Programme Vietnam. © 2024 The Author(s) |
Antimicrobial resistance; Antimicrobial susceptibility; Bacteria; GLASS; Indonesia; Systematic review |
amikacin; cefepime; cefoxitin; ceftazidime; cephalosporin; colistin; cotrimoxazole; doripenem; extended spectrum beta lactamase; fosfomycin; gentamicin; imipenem; meropenem; nitrofurantoin; oxacillin; piperacillin plus tazobactam; quinoline derived antiinfective agent; tigecycline; tobramycin; Acinetobacter baumannii; antibacterial activity; antibiotic resistance; antibiotic sensitivity; Article; bacterial load; bacterium isolation; carbapenem resistance; community acquired infection; disk diffusion; epsilometer test; Escherichia coli; geographic distribution; Haemophilus influenzae; hospital infection; human; Indonesia; infection risk; Klebsiella pneumoniae; matrix assisted laser desorption ionization time of flight mass spectrometry; meta analysis; methicillin resistance; methicillin res |
Kementerian Pendidikan, Kebudayaan, Riset, dan Teknologi, MECRT; Oxford University Clinical Academic Graduate School, OUCAGS; OUCRU; JPT Family Trust; Ministry of Education, Culture, Research, and Technology Republic of Indonesia; Wellcome Africa Asia Programme Vietnam, (106680/Z/14/Z); Lembaga Pengelola Dana Pendidikan, LPDP, (202101182688); Lembaga Pengelola Dana Pendidikan, LPDP |
Funding text 1: Wellcome Africa Asia Programme Vietnam.None. Funding statement: This work was funded by the Wellcome Africa Asia Programme Vietnam (106680/Z/14/Z), which also supports RLH and HRVD. MG was supported by the JPT Family Trust award and Oxford University Clinical Academic Graduate School. RL was supported by an OUCRU Prize Studentship and a Nuffield Dept of Medicine Tropical Network Fu |
Elsevier Ltd |
27723682 |
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55 |
Siregar R.A.; Qorina F.; Kalaij A.G.I.; Afidjati H.; Latifani D.; Utomo M.F.P.; Sophia L.P.; Mahmud A.S. |
Siregar, Risyad Abiyyu (59219062900); Qorina, Fona (57212589681); Kalaij, Ayers Gilberth Ivano (57223906853); Afidjati, Hera (59218375000); Latifani, Dhani (57222220962); Utomo, Muhammad Faisal Putro (59219063000); Sophia, Louisa Patricia (59218505400); Mahmud, Azizah Salsabila (59219063100) |
59219062900; 57212589681; 57223906853; 59218375000; 57222220962; 59219063000; 59218505400; 59219063100 |
Sugar-Sweetened Beverages Taxation Plan in Indonesia: Call for Political Commitment |
2024 |
Public Health Challenges |
3 |
3 |
e217 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85198539750&doi=10.1002%2fpuh2.217&partnerID=40&md5=02c4ed0b6b848ed480e2711da5b9e81e |
School of Public Health, Imperial College London, London, United Kingdom; Evidence-Based Health Policy Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Public Health, Universitas Indonesia, Jakarta, Indonesia; Bhayangkara Tk.I R. Said Sukanto Police Hospital, Jakarta, Indonesia; Faculty of Health Law, Soegijapranata Catholic University, Semarang, Indonesia; Faculty of Medicine, Universitas Pembangunan Nasional “Veteran” Jakarta, Jakarta, Indonesia; Departement of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Siregar R.A., School of Public Health, Imperial College London, London, United Kingdom; Qorina F., Evidence-Based Health Policy Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kalaij A.G.I., Evidence-Based Health Policy Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Afidjati H., Faculty of Public Health, Universitas Indonesia, Jakarta, Indonesia; Latifani D., Departement of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Utomo M.F.P., Bhayangkara Tk.I R. Said Sukanto Police Hospital, Jakarta, Indonesia, Faculty of Health Law, Soegijapranata Catholic University, Semarang, Indonesia; Sophia L.P., Faculty of Medicine, Universitas Pembangunan Nasional “Veteran” Jakarta, Jakarta, Indonesia; Mahmud A.S., Faculty of Medicine, Universitas Pembangunan Nasional “Veteran” Jakarta, Jakarta, Indonesia |
Indonesia is grappling with a rise in obesity and diabetes, partially driven by a high consumption of sugar-sweetened beverages. The prevalence of obesity among adults more than doubled from 2007 to 2018, and diabetes rates have also increased. In response, the Indonesian government has proposed an excise tax on sugar-sweetened beverages to reduce consumption. However, the implementation of this policy has repeatedly been delayed, with the latest postponement to 2024. Sugar-sweetened beverages contribute significantly to chronic diseases, increasing the healthcare burden and reducing economic productivity. Taxation, a widely used public health strategy in the form of fiscal measures, can decrease consumption by raising prices, raising public awareness, encouraging product reformulation, and generating revenue. Despite its potential benefits, the proposed tax in Indonesia faces substantial political and commercial challenges. The president-elect Prabowo Subanto has not explicitly supported the tax in his political manifesto, raising concerns about further delays due to industry lobbying. Successful implementation of the tax requires robust political will, public and civil society pressure, and effective cross-sector cooperation. The government must ensure clear policy goals, equal application to domestic and foreign products, and supportive measures such as providing free drinking water alternatives. Transparent stakeholder consultations can build broad-based support, whereas effective monitoring and evaluation frameworks are essential for compliance. To gain public support, allocating tax revenues to public health and social programs is crucial. Although initial resistance is expected, strong enforcement mechanisms can ensure adherence. With determined political commitment and public advocacy, the sugar-sweetened beverage tax can significantly reduce obesity and diabetes rates, improving public health outcomes and economic productivity in Indonesia. This commentary provides an overview of the proposed tax, explores its challenges, and offers recommendations for successful implementation. © 2024 The Author(s). Public Health Challenges published by John Wiley & Sons Ltd. |
excise tax; Indonesia; policy implementation; sugar-sweetened beverages |
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John Wiley and Sons Inc |
27692450 |
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67 |
Putri Meutia A.; Yonathan K.; Iman Santoso B.; Djusad S.; Priyatini T.; Hakim S.; Moegni F.; Nurul Hidayah G. |
Putri Meutia, Alfa (59214830100); Yonathan, Kevin (57195941933); Iman Santoso, Budi (59214972800); Djusad, Suskhan (57192276788); Priyatini, Tyas (57192265423); Hakim, Surahman (57192276095); Moegni, Fernandi (55450456100); Nurul Hidayah, Gita (59214534300) |
59214830100; 57195941933; 59214972800; 57192276788; 57192265423; 57192276095; 55450456100; 59214534300 |
Translation, Cross-Cultural Adaptation, and Validation of Indonesian Version of Australian Pelvic Floor Questionnaire: An Interviewer-Administered Female Pelvic Floor Questionnaire |
2024 |
European Journal of Obstetrics and Gynecology and Reproductive Biology |
300 |
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155 |
158 |
3 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85198278883&doi=10.1016%2fj.ejogrb.2024.07.005&partnerID=40&md5=fc2a779c700596e0a215fdd74498f7bd |
Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Indonesia; Jakarta Urogynecology Center, YPK Mandiri Hospital, Indonesia; Faculty of Medicine, Universitas Indonesia, Indonesia |
Putri Meutia A., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Indonesia, Jakarta Urogynecology Center, YPK Mandiri Hospital, Indonesia; Yonathan K., Faculty of Medicine, Universitas Indonesia, Indonesia; Iman Santoso B., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Indonesia, Jakarta Urogynecology Center, YPK Mandiri Hospital, Indonesia; Djusad S., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Indonesia; Priyatini T., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Indonesia; Hakim S., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Indonesia; Moegni F., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Indonesia, Jakarta Urogynecology Center, YPK Mandiri Hospital, Indonesia; Nurul Hidayah G., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Indonesia, Jakarta Urogynecology Center, YPK Mandiri Hospital, Indonesia |
Aim: To adapt and determine the validity and reliability of the Indonesian version of the Australian Pelvic Floor Questionnaire (APFQ). Methods: The original APFQ was translated and validated to obtain an Indonesian, physician-administered version on 41 urogynecology patients and 41 age-matched women without pelvic floor dysfunction. Results: Missing answers never exceeded 2%. The questionnaire can significantly discriminate between pelvic floor dysfunction patients and those without dysfunctions. The results of each domain of the questionnaire correlated with clinical examinations and another questionnaire. Cronbach's alpha scores of all domains were 0.859 for bladder function, 0.829 for bowel function, 0.892 for prolapse symptoms, and 0.766 for sexual function. Conclusion: The Indonesian version of the Australian Pelvic Floor Questionnaire (APFQ) is a valid and reliable questionnaire for assessing pelvic floor symptoms among women in Indonesia. © 2024 |
Pelvic floor; Prolapse; Questionnaires; Validation study |
adaptation; adult; age; Article; Australian pelvic floor questionnaire; bladder function; body mass; bothersomeness; clinical article; clinical examination; community dwelling person; controlled study; convergent validity; cross-sectional study; cultural factor; cystocele; demographics; discriminant validity; educational status; face validity; female; Female Sexual Function Index; genital system disease assessment; human; Indonesia; Indonesian (language); internal consistency; intestine function; menopause; parity; pelvic floor disorder; prolapse; questionnaire; rectocele; reliability; sexual abstinence; sexual function; test retest reliability; translating (language); validity |
Jakarta Urogynecology Center |
The authors would like to thank all the participating patients and medical staff in Cipto Mangunkusumo National Hospital and Jakarta Urogynecology Center, Indonesia. Data and Material Availability. Data related to the results of this study are available from the corresponding author upon reasonable requests. |
Elsevier Ireland Ltd |
3012115 |
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71 |
Karyanti M.R.; Uiterwaal C.S.P.M.; Hadinegoro S.R.; Widyahening I.S.; Saldi S.R.F.; Heesterbeek J.A.P.H.; Hoes A.W.; Bruijning-Verhagen P. |
Karyanti, Mulya Rahma (56290680800); Uiterwaal, Cuno S P M (59148037600); Hadinegoro, Sri Rezeki (56893685800); Widyahening, Indah Suci (54893154400); Saldi, Siti Rizny F (55201904000); Heesterbeek, J A P Hans (59134733500); Hoes, Arno W. (35370614300); Bruijning-Verhagen, Patricia (55175644800) |
56290680800; 59148037600; 56893685800; 54893154400; 55201904000; 59134733500; 35370614300; 55175644800 |
The Value of Warning Signs From the WHO 2009 Dengue Classification in Detecting Severe Dengue in Children |
2024 |
The Pediatric infectious disease journal |
43 |
7 |
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630 |
634 |
4 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85196767536&doi=10.1097%2fINF.0000000000004326&partnerID=40&md5=04c0ef35f4c83ec1bb4da39449b609c4 |
From the Department of Child Health, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands; Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Clinical Epidemiology and Evidence-Based Medicine Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Population Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands |
Karyanti M.R., From the Department of Child Health, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands; Uiterwaal C.S.P.M., Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands; Hadinegoro S.R., From the Department of Child Health, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Widyahening I.S., Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Saldi S.R.F., Clinical Epidemiology and Evidence-Based Medicine Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Heesterbeek J.A.P.H., Department of Population Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands; Hoes A.W., Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands; Bruijning-Verhagen P., Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands |
BACKGROUND: World Health Organization proposed 7 warning signs to identify the risk of severe dengue in 2009. This study aimed to evaluate the value of these warning signs in detecting severe dengue in children. MATERIAL AND METHODS: A cross-sectional study was conducted utilizing data of children with clinical dengue infection obtained from medical records between January 2009 and December 2018 in Jakarta. Children with confirmed dengue were analyzed and stratified into 3 age groups: infants less than 1 year old, children 1-14 years and adolescents 15-18 years of age. Positive predictive value, negative predictive value (NPV), sensitivity and specificity of each warning sign present or absent on admission in detecting severe dengue were computed. RESULTS: Six hundred ninety-nine children with clinical dengue infection were enrolled, among whom 614 (87.8%) had confirmed dengue infection, either by antigen or antibody serological tests. Severe dengue occurred in 211/614 (34.4%) cases. In infants, important warning signs on admission to detect or exclude severe dengue were liver enlargement (NPV 80.8%) and clinical fluid accumulation (NPV 75%). In children and adolescents, warning sign with highest NPV (in children 76.6% and in adolescents 91.9%) was increase in hematocrit concurrent with a rapid decrease in platelet count. Other warning signs with high NPV values in children were abdominal pain (72%), vomiting (70%), clinical fluid accumulation (69.3%), and in adolescents' abdominal pain (80.7%), vomiting (75.7%), clinical fluid accumulation (82.7%). NPVs increase with more than 1 warning sign in all age groups. CONCLUSION: In infants, liver enlargement or clinical fluid accumulation are important warning signs for severe dengue, when both are absent, severe dengue is unlikely. In older children and adolescents, an increase in hematocrit with the concurrent rapid decrease in platelet count is most discriminative; followed by the absence of abdominal pain, vomiting or fluid accumulation are unlikely severe dengue. Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. |
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Adolescent; Child; Child, Preschool; Cross-Sectional Studies; Female; Humans; Infant; Male; Sensitivity and Specificity; Severe Dengue; World Health Organization; adolescent; child; cross-sectional study; diagnosis; female; human; infant; male; preschool child; sensitivity and specificity; severe dengue; World Health Organization |
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15320987 |
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83 |
Muharram F.R.; Multazam C.E.C.Z.; Harmadha W.S.; Andrianto A.; Salsabilla S.A.; Dakota I.; Andriantoro H.; Firman D.; Montain M.M.; Prakoso R.; Anggraeni D. |
Muharram, Farizal Rizky (57216980622); Multazam, Chaq El Chaq Zamzam (58251801300); Harmadha, Wigaviola Socha (58251171000); Andrianto, Andrianto (57216770187); Salsabilla, Senitza Anisa (57214878997); Dakota, Iwan (55796663700); Andriantoro, Hananto (55037171500); Firman, Doni (54898724100); Montain, Maya Marinda (58199735300); Prakoso, Radityo (57192893243); Anggraeni, Dilla (59119915800) |
57216980622; 58251801300; 58251171000; 57216770187; 57214878997; 55796663700; 55037171500; 54898724100; 58199735300; 57192893243; 59119915800 |
Distribution of catheterisation laboratories in Indonesia 2017–2022: a nationwide survey |
2024 |
The Lancet Regional Health - Southeast Asia |
26 |
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100418 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85192701300&doi=10.1016%2fj.lansea.2024.100418&partnerID=40&md5=6aba71af307febe729dc45e1d098eab7 |
Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, United States; National Heart and Lung Institute, Imperial College London, London, United Kingdom; Faculty of Medicine, Airlangga University, Soetomo General Hospital, Surabaya, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Centre Harapan Kita, West Jakarta, Indonesia |
Muharram F.R., Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, United States; Multazam C.E.C.Z., National Heart and Lung Institute, Imperial College London, London, United Kingdom; Harmadha W.S., National Heart and Lung Institute, Imperial College London, London, United Kingdom; Andrianto A., Faculty of Medicine, Airlangga University, Soetomo General Hospital, Surabaya, Indonesia; Salsabilla S.A., Faculty of Medicine, Airlangga University, Soetomo General Hospital, Surabaya, Indonesia; Dakota I., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Centre Harapan Kita, West Jakarta, Indonesia; Andriantoro H., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Centre Harapan Kita, West Jakarta, Indonesia; Firman D., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Centre Harapan Kita, West Jakarta, Indonesia; Montain M.M., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Centre Harapan Kita, West Jakarta, Indonesia; Prakoso R., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Centre Harapan Kita, West Jakarta, Indonesia; Anggraeni D., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Centre Harapan Kita, West Jakarta, Indonesia |
Background: Geographical terrains of Indonesia pose a major hindrance to transportation. The difficulty of transportation affects the provision of acute time-dependent therapy such as percutaneous coronary intervention (PCI). Also, Indonesia's aging population would have a significant impact on the prevalence of acute coronary syndrome in the next decade. Therefore, the analysis and enhancement of cardiovascular care are crucial. The catheterisation laboratory performs PCI procedures. In the current study, we mapped the number and distribution of catheterisation laboratories in Indonesia. Methods: A direct survey was used to collect data related to catheterisation laboratory locations in July 2022. The population data was sourced from the Ministry of Home Affairs. The recent growth of catheterisation laboratories was examined and evaluated based on geographical areas. The main instruments for comparing regions and changes throughout time are the ratio of catheterisation laboratories per 100,000 population and the Gini index (a measure of economic and healthcare inequality. Gini index ranges from 0 to 1, with greater values indicating more significant levels of inequality). Regression analysis was carried out to see how the number of catheterisation laboratories was affected by health demand (prevalence) and economic capacity (Gross Domestic Regional Product [GDRP] per Capita). Findings: The number of catheterisation laboratories in Indonesia significantly increased from 181 to 310 during 2017–2022, with 44 of the 119 new labs built in an area that did not have one. Java has the most catheterisation laboratories (208, 67%). The catheterisation laboratory ratio in the provinces of Indonesia ranges from 0.0 in West Papua and Maluku to 4.46 in Jakarta; the median is 1.09 (IQR 0.71–1.18). The distribution remains a problem, as shown by the high catheterisation laboratory Gini index (0.48). Regression shows that distribution of catheterisation laboratories was significantly affected by GDRP and the prevalence of heart disease. Interpretation: The number of catheterisation laboratories in Indonesia has increased significantly recently, however, maldistribution remains a concern. To improve Indonesia's cardiovascular emergency services, future development of catheterisation laboratories must be better planned considering the facility's accessibility and density. Funding: Airlangga Research Fund - Universitas Airlangga. © 2024 The Authors |
Acute coronary syndrome; Cardiovascular Disease; Cath lab; Geospatial analysis; Percutaneous coronary intervention |
acute coronary syndrome; Article; cardiologist; cardiovascular emergency; catheterization; cross-sectional study; economic inequality; emergency health service; geographic distribution; geographic mapping; Gini coefficient; gross domestic regional product; gross national product; health care access; health care facility; health care need; health care survey; health disparity; health infrastructure; heart disease; human; incidence; Indonesia; Irian Jaya; ischemic heart disease; Jakarta; laboratory; low income country; Maluku; middle income country; percutaneous coronary intervention; population research; prevalence; purchasing power; ST segment elevation myocardial infarction |
Airlangga Research Fund - Universitas Airlangga |
We are grateful to Dr. Basuni and Dr. Isman Firdaus for their time and advice in writing this study. We are grateful Airlangga Research Fund - Universitas Airlangga for providing financial support. |
Elsevier Ltd |
27723682 |
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104 |
Chenderawasi S.; Dharma R.; Pohan H.T.; Dewi B.E.; Setiabudy R.; Suhendro; Aryati; Darmawan H.; Nainggolan L.; Iskandar A. |
Chenderawasi, Settrin (57221643087); Dharma, Rahajuningsih (12777817700); Pohan, Herdiman T. (23474782900); Dewi, Beti Ernawati (24076058600); Setiabudy, Rianto (6602316235); Suhendro (57215086884); Aryati (57209860388); Darmawan, Hardi (8581795700); Nainggolan, Leonard (23498394800); Iskandar, Agustin (37079172000) |
57221643087; 12777817700; 23474782900; 24076058600; 6602316235; 57215086884; 57209860388; 8581795700; 23498394800; 37079172000 |
Cut-off Value of HSPG for Early Marker of Plasma Leakage in Adult Dengue Patient |
2024 |
Indonesian Journal of Clinical Pathology and Medical Laboratory |
30 |
3 |
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259 |
264 |
5 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85196512724&doi=10.24293%2fijcpml.v30i3.2221&partnerID=40&md5=c691867fc67c7f2904e3cec2a9cfba6b |
Community-Based Dengue Study, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Clinical Pathology, University of Indonesia, Jakarta, Indonesia; Department of Internal Medicine, University of Indonesia, Jakarta, Indonesia; Department of Microbiology, University of Indonesia, Jakarta, Indonesia; Department of Pharmacology, University of Indonesia, Jakarta, Indonesia; Department of Clinical Pathology, Airlangga University, Surabaya, Indonesia; Department of Physiology, University of Sriwijaya, Palembang, Indonesia; Department of Clinical Pathology, Brawijaya University, Malang, Indonesia |
Chenderawasi S., Community-Based Dengue Study, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Dharma R., Department of Clinical Pathology, University of Indonesia, Jakarta, Indonesia; Pohan H.T., Department of Internal Medicine, University of Indonesia, Jakarta, Indonesia; Dewi B.E., Community-Based Dengue Study, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Department of Microbiology, University of Indonesia, Jakarta, Indonesia; Setiabudy R., Department of Pharmacology, University of Indonesia, Jakarta, Indonesia; Suhendro, Department of Internal Medicine, University of Indonesia, Jakarta, Indonesia; Aryati, Department of Clinical Pathology, Airlangga University, Surabaya, Indonesia; Darmawan H., Department of Physiology, University of Sriwijaya, Palembang, Indonesia; Nainggolan L., Community-Based Dengue Study, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Department of Internal Medicine, University of Indonesia, Jakarta, Indonesia; Iskandar A., Department of Clinical Pathology, Brawijaya University, Malang, Indonesia |
Plasma leakage is a state of increased vascular permeability due to loss of interendothelial junction and focal adhesion. Endothelium glycocalyx plays a major role in the pathogenesis of plasma leakage. Proteoglycans glycocalyx consists of heparan sulfate (HSPG) around 50-90%. Plasma leakage in dengue infection can be fatal and early detection is essential. This study aimed to determine the optimal cut-off value of HSPG levels for early marker of plasma leakage in dengue infection. The study was a retrospective cohort study as a part of the Community Based Dengue Study of the Faculty of Medicine, University of Indonesia, which was conducted between February 2010 and January 2011. Subjects were recruited by consecutive sampling. Dengue infection was confirmed by conventional PCR serotyping. Subjects were categorized into 2 groups, i.e. those with and without plasma leakage. Plasma leakage was confirmed by hemoconcentration or hypoalbuminemia or USG results. The level of HSPG was measured using the ELISA method from the first until the third day of the hospital admission. A total of 40 subjects were involved in this study, consisting of 21 with leakage and 19 without st nd leakage. The optimal cut-off level of HSPG as a marker of early plasma leakage in dengue infection patients on the 1 day, 2 rd day, and 3 day was was 2179.73 pg/mL, 2538.66 pg/mL, and 1294.06 pg/mL, respectively. HSPG could as an early marker of plasma leakage in dengue infection with an optimal cut-off value for each of the first 3 days of the patient's fever. A pediatric study was recommended to obtain the optimal cut-off value for HSPG. © 2024, Indonesian Association of Clinical Pathology and Laboratory Medicine. All rights reserved. |
Dengue; HSPG; plasma leakage marker |
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Community Based Dengue Study Faculty of Medicine Universitas Indonesia |
This study was supported by the Community Based Dengue Study Faculty of Medicine Universitas Indonesia. |
Indonesian Association of Clinical Pathology and Laboratory Medicine |
24774685 |
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107 |
Zuraida; Lestari S.W.; Pangestu M.; Hestiantoro A.; Kusmardi K. |
Zuraida (59198338400); Lestari, Silvia Werdhy (55980501200); Pangestu, Mulyoto (35488897500); Hestiantoro, Andon (8743255100); Kusmardi, Kusmardi (56966625300) |
59198338400; 55980501200; 35488897500; 8743255100; 56966625300 |
Effect of Glutathione Supplementation in Cryoprotectant Modification on Tyrosine Phosphorylation, Acrosin Expression and Acrosome Reaction of Post-Thawing Spermatozoa Quality |
2024 |
Pharmacognosy Journal |
16 |
3 |
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554 |
562 |
8 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85197220932&doi=10.5530%2fpj.2024.16.87&partnerID=40&md5=dfeb77040bde1be16b741ee05c930387 |
Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10430, Indonesia; Department of Midwifery, Faculty of Health, Universitas Fort de Kock Bukittinggi, Jl. Soekarno Hatta No. 11, Sumbar, Bukittinggi, 26117, Indonesia; Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Education Program in Reproduction and Development, Department of Obstetrics and Gynecology, School of Clinical Sciences, Monash University, Victoria, Australia; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia, Jalan Salemba Raya No. 6, Jakarta, 10430, Indonesia; Drug Development Research Center, Indonesia Medical Education and Research Institute (IMERI), Universitas Indonesia, Jalan Salemba Raya No. 6, Jakarta, 10430, Indonesia; Human Cancer Research Center, Indonesia Medical Education and Research Institute (IMERI), Universitas Indonesia, Jalan Salemba Raya No. 6, Jakarta, 10430, Indonesia |
Zuraida, Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10430, Indonesia, Department of Midwifery, Faculty of Health, Universitas Fort de Kock Bukittinggi, Jl. Soekarno Hatta No. 11, Sumbar, Bukittinggi, 26117, Indonesia; Lestari S.W., Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Pangestu M., Education Program in Reproduction and Development, Department of Obstetrics and Gynecology, School of Clinical Sciences, Monash University, Victoria, Australia; Hestiantoro A., Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Kusmardi K., Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia, Jalan Salemba Raya No. 6, Jakarta, 10430, Indonesia, Drug Development Research Center, Indonesia Medical Education and Research Institute (IMERI), Universitas Indonesia, Jalan Salemba Raya No. 6, Jakarta, 10430, Indonesia, Human Cancer Research Center, Indonesia Medical Education and Research Institute (IMERI), Universitas Indonesia, Jalan Salemba Raya No. 6, Jakarta, 10430, Indonesia |
Background: Tyrosine phosphorylation, acrosin, and acrosome reaction play an important role in fertilisation. However, cryopreservation causes changes in tyrosine phosphorylation, acrosin expression, and acrosome reaction which affect the quality of spermatozoa. Cryoprotectant media added with antioxidants is needed to protect Spermatozoa from the effects of cryopreservation so that the quality of spermatozoa can be maintained. Objectives: This research examined the effect of glutathione (GSH) supplementation in cryopreservation media on tyrosine phosphorylation, acrosin expression, and acrosome reaction. In this research, pure modified Cryoprotectant (CPA) was compared with CPA supplemented with GSH in three different concentrations. Materials and Methods: The research sample was male mus musculus albinus strain Deutchland Denken Yoken (DDY). Mice spermatozoa was cryopreserved and several parameters were measured including tyrosine phosphorylation, acrosin expression, and acrosome reaction. Results: The addition of GSH to the modified CPA increased tyrosine phosphorylation, acrosin expression, and acrosome reaction (maintaining acrosome integrity). The group with 1.00 mM GSH obtained the highest results among the other groups. Significant increases were found in tyrosine phosphorylation, acrosin expression, and acrosome reaction after the addition of 1.00 mM GSH. Conclusion: Glutathione supplementation in modified CPA can increase tyrosine phosphorylation, acrosin expression, and acrosome reaction of frozen-thawed spermatozoa. Treatment using GSH at a dose of 1.00 mM is the most effective and modification of CPA with the addition of glutathione can improve the tyrosine phosphorylation, acrosin expression and acrosome reaction in cryopreserved spermatozoa. © 2024 Phcogj.Com. |
acrosin expression; acrosome reaction; CPA modification; glutathione (GSH); spermatozoa cryopreservation; tyrosine phosphorylation |
acrosin; cryoprotective agent; glutathione; acrosome reaction; animal experiment; animal model; animal tissue; Article; controlled study; cryopreservation; environmental change; female; freeze thawing; human; human cell; hydrogen bond; immunocytochemistry; male; molecular weight; mouse; Mus musculus; nonhuman; polyacrylamide gel electrophoresis; protein expression; protein phosphorylation; sperm quality; supplementation; Western blotting |
Ministry of Finance of the Republic of Indonesia; Universitas Fort de Kock Bukittinggi; Medical Faculty Universitas Indonesia |
We would like to thanks to Lembaga Pengelola Dana Pendidikan (LPDP) of the Ministry of Finance of the Republic of Indonesia for funding this research and Universitas Fort de Kock Bukittinggi for granting learning permit to pursue the doctoral study in Biomedical Science at the Medical Faculty Universitas Indonesia |
EManuscript Technologies |
9753575 |
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139 |
Leung A.S.Y.; Pawankar R.; Pacharn P.; Wong L.S.Y.; Le Pham D.; Chan G.; Rengganis I.; Zhao J.; Wang J.Y.; Woo K.C.-K.; Ito K.; Jeong K.; Recto M.; Lucas M.; Nagao M.; Lobo R.C.M.; Munkhbayarlakh S.; Sumadiono S.; Huq S.R.; Ranasinghe T.; Tang M. |
Leung, Agnes Sze Yin (56194894700); Pawankar, Ruby (7005904460); Pacharn, Punchama (24381917200); Wong, Lydia Su Yin (57218858199); Le Pham, Duy (57201431490); Chan, Grace (55901236000); Rengganis, Iris (8449988000); Zhao, Jing (57189080667); Wang, Jiu Yao (56499349900); Woo, Kent Chee-Keen (40361622200); Ito, Komei (56416822300); Jeong, Kyunguk (57114247400); Recto, Marysia (57193521921); Lucas, Michaela (7201860389); Nagao, Mizuho (15070720700); Lobo, Rommel Crisenio M. (57216979489); Munkhbay |
56194894700; 7005904460; 24381917200; 57218858199; 57201431490; 55901236000; 8449988000; 57189080667; 56499349900; 40361622200; 56416822300; 57114247400; 57193521921; 7201860389; 15070720700; 57216979489; 56800881300; 55581650500; 58888861300; 57223887984; 7401973909 |
Perspectives and gaps in the management of food allergy and anaphylaxis in the Asia-Pacific Region |
2024 |
Journal of Allergy and Clinical Immunology: Global |
3 |
2 |
100202 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85185181555&doi=10.1016%2fj.jacig.2023.100202&partnerID=40&md5=ff4f178ac07a5ff3b9097c5c2905b7da |
Department of Paediatrics, Prince of Wales Hospital, Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong; Division of Allergy, Department of Pediatrics, Nippon Medical School, Tokyo, Japan; Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Department of Paediatrics, Yong Loo Lin School of Medicine and Khoo Teck Puat-National University Children's Medical Institute, National University of Singapore, Singapore, Singapore; University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam, Ho Chi Minh City, Viet Nam; Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore, Singapore; Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Capital Institute of Pediatrics in China, Beijing, China; Division of Allergy and Clinical Immunology, Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Gleneagles Hospital, Kuala Lumpur, Malaysia; Allergy and Immunology Center, Aichi Children's Health And Medical Center, Aichi, Japan; Ajou University School of Medicine, Suwon, South Korea; Division of Adult and Pediatric Allergy and Immunology, University of the Philippines College of Medicine, Philippine General Hospital, Manila, Philippines; WA Health and University of Western Australia, Perth, Australia; National Hospital Organization Mie National Hospital, Tsu, Japan; Fe del Mundo Medical Center, Manila, Metro Manila, Philippines; Department of Pulmonology and Allergology, School of Medicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia; Department of Child Health, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia; National Institute of the Chest Disease and Hospital NIDCH Mohakhali, Dhaka, Bangladesh; Allergy, Immunology and Cell Biology Unit, University of Sri Jayewardenepura, Nugegoda, Sri Lanka; Allergy Immunology, Murdoch Children's Research Institute, Department of Allergy and Immunology, The Royal Children's Hospital Melbourne, Melbourne, Australia |
Leung A.S.Y., Department of Paediatrics, Prince of Wales Hospital, Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong; Pawankar R., Division of Allergy, Department of Pediatrics, Nippon Medical School, Tokyo, Japan; Pacharn P., Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Wong L.S.Y., Department of Paediatrics, Yong Loo Lin School of Medicine and Khoo Teck Puat-National University Children's Medical Institute, National University of Singapore, Singapore, Singapore; Le Pham D., University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam, Ho Chi Minh City, Viet Nam; Chan G., Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore, Singapore; Rengganis I., Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Zhao J., Capital Institute of Pediatrics in China, Beijing, China; Wang J.Y., Division of Allergy and Clinical Immunology, Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Woo K.C.-K., Gleneagles Hospital, Kuala Lumpur, Malaysia; Ito K., Allergy and Immunology Center, Aichi Children's Health And Medical Center, Aichi, Japan; Jeong K., Ajou University School of Medicine, Suwon, South Korea; Recto M., Division of Adult and Pediatric Allergy and Immunology, University of the Philippines College of Medicine, Philippine General Hospital, Manila, Philippines; Lucas M., WA Health and University of Western Australia, Perth, Australia; Nagao M., National Hospital Organization Mie National Hospital, Tsu, Japan; Lobo R.C.M., Fe del Mundo Medical Center, Manila, Metro Manila, Philippines; Munkhbayarlakh S., Department of Pulmonology and Allergology, School of Medicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia; Sumadiono S., Department of Child Health, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia; Huq S.R., National Institute of the Chest Disease and Hospital NIDCH Mohakhali, Dhaka, Bangladesh; Ranasinghe T., Allergy, Immunology and Cell Biology Unit, University of Sri Jayewardenepura, Nugegoda, Sri Lanka; Tang M., Allergy Immunology, Murdoch Children's Research Institute, Department of Allergy and Immunology, The Royal Children's Hospital Melbourne, Melbourne, Australia |
Background: Food allergy (FA), which is a condition that has no effective cure and can result in severe life-threatening allergic reactions, remains a global public health concern; however, little is known about how FAs are currently managed in the Asia-Pacific region. Objective: The main objective of this survey was to evaluate the epidemiology of FA, as well as the availability of resources and practices for management of FA and anaphylaxis by health care providers across Asia. Methods: From June 2022 to September 2022, a questionnaire-based survey comprising 66 questions was electronically sent to member societies of the Asia Pacific Association of Allergy Asthma and Clinical Immunology by using Survey Monkey. Results: A total of 20 responses were received from 15 member countries and territories. Compared with the pediatric data, there was a lack of prevalence data for FA in adults. Except for Australia and Japan, most regions had between 0.1 and 0.5 allergists per 100,000 population and some had fewer than 0.1 allergists per 100,000 population. The perceived rate of FA in regions with a short supply of allergists was high. Although specific IgE tests and oral food challenges were available in all regions, the median wait time for oral food challenges at government facilities was 37 days (interquartile range = 10.5-60 days). Seven regions still relied on prescriptions of ampules and syringes of injectable adrenaline, and adrenaline autoinjectors were not accessible in 4 regions. Oral immunotherapy as FA treatment was available in half of the surveyed countries and territories. Conclusions: Our study offers a cross-sectional evaluation of the management practices for FA in each Asia Pacific Association of Allergy Asthma and Clinical Immunology member country or territory. Urgent actions are required to enhance allergy services, improve the accessibility and affordability of adrenaline autoinjectors, and conduct robust epidemiologic studies. © 2023 The Author(s) |
adrenaline autoinjector; allergist; allergy service; anaphylaxis; Food allergy |
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Elsevier B.V. |
27728293 |
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156 |
Inawaty I.; Sari I.P.; Susanto L.; Kartikasari D.P.; Oswari H.; Kurniawan A. |
Inawaty, Inawaty (59222219400); Sari, Ika Puspa (57197543698); Susanto, Lisawati (6507704130); Kartikasari, Dwi Peni (57201071066); Oswari, Hanifah (12777323800); Kurniawan, Agnes (6506883360) |
59222219400; 57197543698; 6507704130; 57201071066; 12777323800; 6506883360 |
Occult Amebiasis among Pediatric with Enterocolitis in National Referral Hospital in Indonesia |
2024 |
Infection and Chemotherapy |
56 |
2 |
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230 |
238 |
8 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85198751092&doi=10.3947%2fic.2023.0099&partnerID=40&md5=000789a13b59ab76561ef0f40d996da5 |
Medical Specialist Program in Clinical Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Department of Child Health, Faculty of Medicine, Universitas Indonesia-RSUPN, Dr. Cipto Mangunkusumo, Jakarta, Indonesia |
Inawaty I., Medical Specialist Program in Clinical Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sari I.P., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Susanto L., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kartikasari D.P., Department of Parasitology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Oswari H., Department of Child Health, Faculty of Medicine, Universitas Indonesia-RSUPN, Dr. Cipto Mangunkusumo, Jakarta, Indonesia; Kurniawan A., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Enterocolitis and gastroenteritis remain major health problems, particularly in children living in developing countries. Intestinal protozoa, such as Entamoeba histolytica, Blastocystis, and Cyclospora, are frequently associated with these conditions. Amebic colitis can cause serious complications, including fulminant necrotizing colitis, toxic megacolon, extraintestinal amebiasis, and stunting in children. The diagnosis of amoebiasis is challenging, relying on microscopic examination, which cannot distinguish E. histolytica from the nonpathogenic E. dispar and E. moshkovskii. Therefore, this study aimed to identify intestinal parasites, particularly Entamoeba, their prevalence, and the clinical characteristics of patients admitted for enterocolitis and gastroenteritis at a tertiary-referral hospital. Material and Methods: A cross-sectional, retrospective study was conducted at a national, tertiary-referral government hospital, in Jakarta. Of the 111 retrieved medical records from hospitalized patients with enterocolitis and gastroenteritis, for which parasitology feces were examined, 54 fecal samples (48.6%) were still available in the parasitology laboratory storage. All fecal samples underwent the following tests: 1) direct stool examination, after staining with 1% Lugol’s solution, and using the water–ether concentration method; 2) modified acid-fast staining for coccidian parasites; 3) Jones’ culture medium to detect Blastocystis; 4) copro-antigen assay to detect Cryptosporidium and Giardia; and 5) a polymerase chain reaction (PCR) assay to identify Entamoeba. Clinical and demographic data were obtained from the medical records. Results: Largely, patients (44.1%) were from the cohort of young children ≤5 years old, followed by adults aged 19–60 years old (24.3%). Both cohorts exhibited polyparasitism. Intestinal parasites were detected in 17 out of the 54 samples (31.4%). These included 6 (11.1%), 2 (3.7%),5 (9.2%), 3 (5.5%), 2 (3.7%), and 1 (1.8%) samples that were positive for Blastocystis, E dispar, E. histolytica, E. moshkovskii, Cryptosporidium, and Dientamoeba fragilis, respectively. PCR analysis revealed that 10 samples were positive for Entamoeba infection, eight of which originated from pediatric patients. Conclusion: At a national tertiary-referral hospital in Indonesia, Entamoeba infection was the most prevalent parasite among pediatric patients with enterocolitis. E. histolytica and E. moshkovskii were the two main species identified by PCR. Therefore, PCR assays and fecal occult–blood tests are recommended in cases of enterocolitis and gastroenteritis. © 2024 by The Korean Society of Infectious Diseases, Korean Society for Antimicrobial Therapy, The Korean Society for AIDS, and Korean Society of Pediatric Infectious Diseases. |
Diarrhea; Entamoeba histolytica; Entamoeba moshkovskii; Pediatric population; Polymerase chain reaction |
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Universitas Indonesia Fund, (NKB-128/UN2.RST/HKP.05.00/2022) |
This study has been received funding support by the Universitas Indonesia Fund (Pasca Sarjana Contract No. NKB-128/UN2.RST/HKP.05.00/2022). |
Korean Society of Infectious Diseases, Korean Society for Antimicrobial Therapy, Korean Society for AIDS, Korean Society of Pediatric Infectious Diseases |
20932340 |
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