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Sudjono C.; Quinncilla K.H.; Qonita M.; Wijaya N.J.; Kurnain D. |
Sudjono, Clinton (59196697600); Quinncilla, Kiara Hanna (59136515900); Qonita, Ms (59195443000); Wijaya, Nicholas Jason (58483356100); Kurnain, Dave (59196070600) |
59196697600; 59136515900; 59195443000; 58483356100; 59196070600 |
Early Menarche as a Protective Factor Against Cardiovascular Events: A Systematic Review and Meta-analysis |
2024 |
Anatolian journal of cardiology |
28 |
7 |
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329 |
338 |
9 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85197189251&doi=10.14744%2fAnatolJCardiol.2024.3996&partnerID=40&md5=fcfbfda7ab7b31922e8582c997fc0e7a |
Department of Cardiology, Faculty of Medicine, Tarumanagara University, Jakarta, Indonesia; Sebelas Maret University, Surakarta, Indonesia; Jenderal Soedirman University, Purwokerto, Indonesia; Undergraduate Medical Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Sudjono C., Department of Cardiology, Faculty of Medicine, Tarumanagara University, Jakarta, Indonesia; Quinncilla K.H., Sebelas Maret University, Surakarta, Indonesia; Qonita M., Jenderal Soedirman University, Purwokerto, Indonesia; Wijaya N.J., Undergraduate Medical Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kurnain D., Department of Cardiology, Faculty of Medicine, Tarumanagara University, Jakarta, Indonesia |
BACKGROUND: Women are often neglected in cardiovascular health prevention. Age at menarche (AAM) has been linked to cardiovascular (CVD) disease in women and is potentially identified as one of the significant CVD risk factor. However, there is still limited comprehensive evidence addressing this issue. This systematic review and meta-analysis aimed to investigate how early menarche affects the outcome of all-cause mortality, CVD mortality, total cardiovascular disease event, stroke (ischemic, hemorrhagic, and total stroke), and coronary heart disease (CHD). METHOD: The Cochrane Library, MEDLINE, Embase, ScienceDirect, and Google Scholar databases were searched from March 2013 to March 2023 for cohorts investigating the effect of early onset of menarche on CVD events with a minimum follow-up period of 5 years. Studies that observed specific population and/or included women with a history of CVD at baseline were excluded. The Newcastle-Ottawa scale was used for risk of bias assessment for each cohort included. The data were presented as dichotomous measure using risk ratios. I2 statistics were utilized to evaluate the heterogeneity of presented data. RESULTS: Thirteen cohorts included 18 626 799 female patients with ages ranging from 43 to 62.6 years. These reported 6 estimates each for CHD (5 483 298 patients) and all-cause mortality (1 595 878 patients), 5 estimates each for total stroke (2 941 321 patients) and CVD mortality (1 706 742 patients), 4 estimates each for total CVD events (3 988 311 patients) and ischemic stroke (2 434 580 patients), and 1 estimate for hemorrhagic stroke (66 104 patients). Our study found that events of CHD were significantly lower in early menarche (RR 0.57; 95% CI 0.41-0.78; P <.00001), as well as total stroke (RR 0.51; 95% CI 0.35-0.73; P =.0003), CVD mortality (RR 0.47; 95% CI 0.22-0.98; P =.04), total CVD events (RR 0.44; 95% CI 0.25-0.76; P =.003), ischemic stroke (RR 0.31; 95% CI 0.15-0.61; P <.0008), and hemorrhagic stroke (RR 0.12; 95% CI 0.07-0.20; P <.00001); and insignificantly higher in all-cause mortality (RR 0.90, 95% CI 0.76-1.06, P =.20). CONCLUSION: In our study, cardiovascular events are lower in women with early menarche; hence, the later age of menarche is a potential risk factor to be considered when assessing CVD risk in a patient. However, our sample characteristics were heterogenous, and we did not consider other female hormonal factors that might potentially contribute to the CVD outcomes observed; thus, further studies are needed to clarify. |
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Age Factors; Cardiovascular Diseases; Female; Humans; Menarche; Middle Aged; Protective Factors; Risk Factors; age; cardiovascular disease; female; human; menarche; meta analysis; middle aged; mortality; prevention and control; protection; risk factor |
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21492271 |
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38940409 |
Article |
Q3 |
290 |
15434 |
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8 |
Sekarsari D.; Handoyono Q.F.; Amal M.Y.; Maharani M.A.P.; Hendriarto A. |
Sekarsari, Damayanti (57193342279); Handoyono, Quinta Febryani (58993286100); Amal, Mohamad Yanuar (57221702104); Maharani, Maria Angela Putri (58158818200); Hendriarto, Andra (57216821517) |
57193342279; 58993286100; 57221702104; 58158818200; 57216821517 |
Pediatric paraparesis: Radiological challenges in multidrug-resistant tuberculous spondylitis based on experience in Indonesia |
2024 |
Radiology Case Reports |
19 |
8 |
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3287 |
3293 |
6 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85193445919&doi=10.1016%2fj.radcr.2024.04.001&partnerID=40&md5=71f94f873b95af48e9249b2aeb5dc7ea |
Division of Pediatric Radiology, Department of Radiology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Department of Radiology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Department of Anatomic Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Department of Orthopedics and Traumatology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia |
Sekarsari D., Division of Pediatric Radiology, Department of Radiology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Handoyono Q.F., Department of Radiology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Amal M.Y., Division of Pediatric Radiology, Department of Radiology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Maharani M.A.P., Department of Anatomic Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Hendriarto A., Department of Orthopedics and Traumatology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia |
Multidrug-resistant tuberculous spondylitis is a global health issue, especially in developing nations, and non-specific symptoms lead to delay in identification, treatment, and potential disability in children. Radiology plays a crucial role in diagnosing tuberculous spondylitis, which in turn might lead to effective treatment, prevention of disability and improved patient outcomes. Our case involved a 20-month-old malnourished child presented with paraparesis, revealing a history of contact with parental multidrug-resistant tuberculosis. Multimodality radiological examinations, including conventional radiography, CT, and MRI revealed extensive disease of the spine with disc involvement, large paravertebral abscess, and kyphotic deformity which produced neurological deficits, necessitating both anti-tuberculosis regimen and surgical intervention. Radiological examinations have a pivotal role in diagnosing, evaluating and guiding timely management of multidrug-resistant tuberculous spondylitis. Prompt diagnosis of the condition is crucial in order to prevent potentially severe complications, which contribute significantly to morbidity. Our case demonstrated the importance of radiology in diagnosing extensive spine involvement of the disease causing neurological deficits. Furthermore, radiology also helps in managing tuberculous spondylitis to prevent future disability in a child patient of a developing country. This case highlights the crucial significance of radiological imaging in the diagnosis and management of pediatric tuberculous spondylitis in impoverished nations. The patient's complex medical history highlights the socioeconomic factors contributing to tuberculosis burden. Early and comprehensive radiological assessment, together with collaboration between radiologists and clinicians, is vital for timely intervention and improved outcomes in pediatric tuberculous spondylitis cases to prevent the impact of this debilitating disease on children. © 2024 |
Pediatric imaging; Tuberculosis; Tuberculous spondylitis |
abscess; Article; Babinski reflex; case report; child; clinical article; computer assisted tomography; erythrocyte sedimentation rate; female; gait; ground glass opacity; human; Indonesia; kyphosis; lung consolidation; lung fibrosis; malnutrition; multidrug resistant tuberculosis; muscle strength; neurologic examination; nuclear magnetic resonance imaging; paraplegia; physical examination; preschool child; radiodiagnosis; radiological parameters; tuberculous spondylitis |
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Elsevier Inc. |
19300433 |
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Article |
Q4 |
226 |
17897 |
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10 |
Atmodiwirjo P.; Bangun K.; Rachadian Ramadan M.; Tania V.; Djohan M.; Ralena N.A.; Amanda N.F. |
Atmodiwirjo, Parintosa (57203016968); Bangun, Kristaninta (36902624600); Rachadian Ramadan, Mohamad (57222667572); Tania, Vika (57394760300); Djohan, Michael (59205590300); Ralena, Nadhira Anindita (57214093149); Amanda, Nadira Fildza (59205390500) |
57203016968; 36902624600; 57222667572; 57394760300; 59205590300; 57214093149; 59205390500 |
Does Free Fibular Flap Reconstruction Affect the Quality of Life in Pediatric Patients with Various Extend of Mandible Defects? |
2024 |
Journal of Craniofacial Surgery |
35 |
5 |
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1411 |
1416 |
5 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85197653880&doi=10.1097%2fSCS.0000000000010347&partnerID=40&md5=95fd58446d12f8870a0550e28ee2edd3 |
Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Indonesia; Reconstructive Microsurgery and Oncoplasty Section, Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Dr. Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Cleft and Craniofacial Centre, Dr. Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Atmodiwirjo P., Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Indonesia, Reconstructive Microsurgery and Oncoplasty Section, Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Dr. Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Bangun K., Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Indonesia, Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Cleft and Craniofacial Centre, Dr. Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rachadian Ramadan M., Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Indonesia, Reconstructive Microsurgery and Oncoplasty Section, Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Dr. Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Tania V., Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Indonesia, Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Cleft and Craniofacial Centre, Dr. Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Djohan M., Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Indonesia; Ralena N.A., Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Indonesia; Amanda N.F., Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Indonesia |
Background: The long-term outcomes in pediatric patients with various extents of mandible defects have not been well-documented. Methods: A retrospective case series in which this study looked at pediatric patients under the age of 13 who had mandibular reconstruction with free fibular flap and had not received another operation in the previous 6 months. The eating, swallowing, speech function, and quality of life are evaluated with EORTC QLQ-H&N35 after the mandible growth spurt has occurred. Results: A total of 7 patients were included in this study with operation ages ranging from 6 years 1 month to 12 years 2 months. The etiology of malignant tumors was found in 2 patients and benign tumors in 5 patients. The mandibular defect distribution consists of 1 class Ic, 1 class II, 2 class IIc, 2 class III, and 1 class IVc. All patients reported no swallowing or speech difficulties. However, transient eating trouble was seen in 1 patient due to the extensive defect size that causes tooth loss. Only 1 patient received dental rehabilitation. The patients displayed an overall good quality of life with an average score of 2.857. Conclusions: Free fibular flap for mandibular reconstruction in children who have not reached their mandibular growth peak have a satisfying outcome, both in their function and quality of life. © 2024 Lippincott Williams and Wilkins. All rights reserved. |
Fibular flap; mandible; pediatric; quality of life; reconstruction |
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Lippincott Williams and Wilkins |
10492275 |
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Article |
Q2 |
396 |
12572 |
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12 |
Kreshanti P.; Supriadi S.; Kekalih A.; Rahyussalim A.J.; Priosoeryanto B.P.; Noviana D.; Hatibie M.J.; Sukasah C.L.; Aditya A. |
Kreshanti, Prasetyanugraheni (36192866200); Supriadi, Sugeng (16040272500); Kekalih, Aria (55633562200); Rahyussalim, Ahmad Jabir (59175656700); Priosoeryanto, Bambang Pontjo (6603282841); Noviana, Deni (6505909761); Hatibie, Mendy Juniaty (59205710000); Sukasah, Chaula Luthfia (57218391534); Aditya, Andi (59205317400) |
36192866200; 16040272500; 55633562200; 59175656700; 6603282841; 6505909761; 59205710000; 57218391534; 59205317400 |
Novel Design of Interlocking 3-Dimensional Miniplate in Mandibular Angle Fractures: An In Vitro Study |
2024 |
Journal of Craniofacial Surgery |
35 |
5 |
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1591 |
1596 |
5 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85197609249&doi=10.1097%2fSCS.0000000000010372&partnerID=40&md5=b5a77886414f48b5c9e9489a5154c45d |
Doctoral Program in Medical Sciences Faculty of Medicine Universitas Indonesia, Department of Surgery, Universitas Indonesia, Depok, Indonesia; Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Universitas Indonesia, Depok, Indonesia; Departments of Community Medicine, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Departments of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, Indonesia; Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, Indonesia; Cleft and Craniofacial Center, United States; Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Division of Veterinary Pathology, School of Veterinary Medicine and Biomedical Sciences, Ipb University, Bogor, Indonesia; Division of Surgery and Radiology, School of Veterinary Medicine and Biomedical Sciences, Ipb University, Bogor, Indonesia; Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Faculty of Medicine, Sam Ratulangi University, Manado, Indonesia |
Kreshanti P., Doctoral Program in Medical Sciences Faculty of Medicine Universitas Indonesia, Department of Surgery, Universitas Indonesia, Depok, Indonesia, Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Universitas Indonesia, Depok, Indonesia, Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, Indonesia, Cleft and Craniofacial Center, United States; Supriadi S., Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, Indonesia, Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, Indonesia; Kekalih A., Departments of Community Medicine, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Rahyussalim A.J., Departments of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Priosoeryanto B.P., Division of Veterinary Pathology, School of Veterinary Medicine and Biomedical Sciences, Ipb University, Bogor, Indonesia; Noviana D., Division of Surgery and Radiology, School of Veterinary Medicine and Biomedical Sciences, Ipb University, Bogor, Indonesia; Hatibie M.J., Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Faculty of Medicine, Sam Ratulangi University, Manado, Indonesia; Sukasah C.L., Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Universitas Indonesia, Depok, Indonesia; Aditya A., Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, Indonesia |
The evolution of osteosynthesis has led to the development of novel miniplate designs, including 3-dimensional (3D) miniplates, which offer improved biomechanical stability. However, mandible fractures resulting from the high impact have a complex fracture configuration. Hence, the authors developed interlocking 3D miniplate to overcome the difficulty in miniplate and screw placement to avoid critical anatomic structures, that is, dental roots and nerve, while still providing stability for the fracture fragments. The interlocking 3D miniplates can be formed according to the specific needs by adjusting the horizontal and vertical cross struts configuration. This study describes a design process of interlocking 3D miniplates and evaluates biomechanical performance compared to standard miniplates. Finite element analysis was performed to evaluate the design's stress state using human and goat mandible models under various loading conditions. After the authors, established that our design was feasible for fabrication, the authors developed the prototype for biomechanical testing. Biomechanical testing was conducted on 10 goat mandibles to compare stability and displacement under various load between the interlocking 3D miniplate and the standard miniplate configuration. Biomechanical testing revealed reduced displacement in all directions with the interlocking 3D miniplate compared to the standard miniplate. Furthermore, there was a significant difference in all loads in the buccal-lingual displacement (P<0.05). The novel interlocking 3D miniplate design shows an adequate ability to provide stability for fixation for mandibular fractures, as evidenced by finite element analysis and biomechanical testing. Further research is necessary to validate these findings and explore the clinical application of interlocking 3D miniplates in mandibular fracture management. Copyright © 2024 by Mutaz B. Habal, MD. |
Biomechanics; experimental; finite element analysis; implants; internal fixator; mandibular fracture |
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PUTI; Universitas Indonesia, UI, (NKB-592/UN2.RST/HKP.05.00/2020); Universitas Indonesia, UI |
This work was supported by PUTI Doktoral from Universitas Indonesia. Grant number: NKB-592/UN2.RST/HKP.05.00/2020. |
Lippincott Williams and Wilkins |
10492275 |
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Article |
Q2 |
396 |
12572 |
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15 |
Kreshanti P.; Djarot K.R.; Kaligis F.; Friska D.; Swanson J.W.; Blum J.; Martin V.J.; Bangun K. |
Kreshanti, Prasetyanugraheni (36192866200); Djarot, Kasih Rahardjo (57207775552); Kaligis, Fransiska (36604651700); Friska, Dewi (57202805330); Swanson, Jordan W. (56651699500); Blum, Jessica (57560105100); Martin, Valencia Jane (57221635093); Bangun, Kristaninta (36902624600) |
36192866200; 57207775552; 36604651700; 57202805330; 56651699500; 57560105100; 57221635093; 36902624600 |
Translation, Validation, and Cultural Adaptation of CLEFT-Q© for use in Indonesia |
2024 |
Cleft Palate Craniofacial Journal |
61 |
7 |
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1202 |
1212 |
10 |
2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85150940935&doi=10.1177%2f10556656231160392&partnerID=40&md5=7be297a70a6a1867057f192c4e5d12ff |
Cleft and Craniofacial Center Dr. Cipto Mangunkusumo Hospital, Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Psychiatry, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Division of Plastic, Reconstructive and Oral Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States |
Kreshanti P., Cleft and Craniofacial Center Dr. Cipto Mangunkusumo Hospital, Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Djarot K.R., Cleft and Craniofacial Center Dr. Cipto Mangunkusumo Hospital, Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Kaligis F., Department of Psychiatry, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Friska D., Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Swanson J.W., Division of Plastic, Reconstructive and Oral Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States; Blum J., Division of Plastic, Reconstructive and Oral Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States; Martin V.J., Cleft and Craniofacial Center Dr. Cipto Mangunkusumo Hospital, Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Bangun K., Cleft and Craniofacial Center Dr. Cipto Mangunkusumo Hospital, Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Objective: To translate and validate CLEFT-Q©, patient-reported outcome measure for patients with cleft lip and/or palate (CL and/or P), into Indonesian. CLEFT-Q© covers the domains of appearance, facial function, health-related quality of life and consists of scales describing outcomes after cleft surgery. Design: The CLEFT-Q© instrument was translated according to the International Society of Pharmacoeconomics and Outcomes Research guidelines, including translation, cognitive debriefing, and field-testing. Setting: Dr. Cipto Mangunkusumo Hospital, Indonesia; independent CL and/or P support groups. Patients: Patients ages 8-29 with a history of repaired CL and/or P were grouped based on age. Those unable to complete the questionnaire independently were excluded. Interventions: The primary objective was reliable translation of the CLEFT-Q® instrument. Each scale was assessed for its internal consistency (Cronbach's alpha) and validity (inter-item correlation), and sub-group analyses were performed based on age group. Results: Forward and back translation revealed 25(13.3%) and 12(6.3%) of items were difficult to translate. Cognitive debriefing revealed 10(5.3%) items were difficult to understand, with the lowest reliability on the facial appearance scale (α=0.27). Other scales demonstrated acceptable to excellent reliability (α=0.53–0.68). Field testing revealed acceptable reliability and validity of the translation (α = 0.74-0.92; 69% ideal range of inter-item correlation). Sub-group analyses revealed patients in the <11y.o. and >18y.o. groups had the lowest scores on the “cleft lip scar” scale while those 11-18y.o. had the lowest scores on the “nostrils” scale. Conclusion: Iterative translation and cultural adaptation of CLEFT-Q© into Indonesian demonstrated reliability and validity of the tool, supported by acceptable to excellent internal consistency and ideal inter-item correlation. © 2023, American Cleft Palate Craniofacial Association. |
counseling; nonsyndromic clefting; psychological assessment; psychosocial adjustment; quality of life; speech perception |
Adolescent; Adult; Child; Cleft Lip; Cleft Palate; Female; Humans; Indonesia; Male; Patient Reported Outcome Measures; Psychometrics; Quality of Life; Reproducibility of Results; Surveys and Questionnaires; Translations; adolescent; adult; Article; child; cleft lip; cleft lip palate; cleft palate; CLEFT Q Scale; clinical article; cognition assessment; construct validity; content validity; controlled study; Cronbach alpha coefficient; facies; female; groups by age; human; Indonesia; internal consistency; male; oral surgery; patient history of surgery; patient-reported outcome; quality of life; scar; support group; cleft lip; cleft palate; psychology; psychometry; publication; quality of life; questionnaire; reproducibility; surgery |
Direktorat Riset and Pengembangan, Universitas Indonesia, DRPM UI, (NKB-1251/UN.2RST/HKP.05.00/2022); Direktorat Riset and Pengembangan, Universitas Indonesia, DRPM UI |
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research is funded by Directorate of Research and Development, Universitas Indonesia under Hibah PUTI 2023 (Grant No. NKB-1251/UN.2RST/HKP.05.00/2022)”. |
SAGE Publications Ltd |
10556656 |
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36949554 |
Article |
Q2 |
545 |
9490 |
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17 |
Julian J.; Adawiyah R.; Wahdini S. |
Julian, Julian (58677322900); Adawiyah, Robiatul (57208658742); Wahdini, Sri (57203684068) |
58677322900; 57208658742; 57203684068 |
BIOMOLECULAR ACTIVITY OF CRYPTOCOCCUS DURING CRYPTOCOCCOSIS: A REVIEW OF MOLECULAR INTERACTIONS OF CRYPTOCOCCUS WITH HUMAN IMMUNE SYSTEM AND BLOOD-BRAIN-BARRIER |
2024 |
African Journal of Infectious Diseases |
18 |
1 |
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11 |
22 |
11 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85175528279&doi=10.21010%2fAjidv18i1.3&partnerID=40&md5=fd5671eda00d2ed2b911492e8e87a566 |
Master‟s Programme in biomedical science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Julian J., Master‟s Programme in biomedical science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Adawiyah R., Master‟s Programme in biomedical science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wahdini S., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Global mycosis is still a problem. One of these is the cryptococcal disease. A systemic mycosis brought on by Cryptococcus is called cryptococcosis. Host immunological conditions influence infection with Cryptococcosis. When environmental spores are inhaled by the host, the spores get to the lungs, an infection is created. Alveolar macrophages and other immune cells recognize Cryptococcus in the lung. The initial line of defense against pathogens in the phagolysosome is provided by alveolar macrophages found in the lungs. When the immune system is weak, Cryptococcus uses the evasion system as a molecular interaction with the immune system and persists in the lungs without causing any symptoms such as Factor Transcription, Cell masking, N-glycan structure, Extracellular molecule, and Antioxidant system. The evasion mechanism protects and makes Cryptococcus disseminate throughout the other organs, especially CNS. If Cryptococcus escapes against the host immune system, it will disseminate to other organs, especially Cerebrospinal System by Three mechanisms. There are Trojan Horse, Paracellular, and Transcellular interactions with Blood-Brain Barrier. Disease severity is determined by the Interaction between the host‟s immune system and the fungus. © 2024, African Traditional, Herbal Medicine Supporters Initiative. All rights reserved. |
Biomolecular Activity; Blood-Brain-Barrier; Cryptococcus; Fungal Disease; Immune Response |
fibrinogen; gamma interferon; glycan; Hermes antigen; interleukin 13; interleukin 1beta; nitric oxide; pathogen associated molecular pattern; reactive oxygen metabolite; toll like receptor; toll like receptor 4; toll like receptor 9; tumor necrosis factor; antioxidant activity; apoptosis; Article; blood brain barrier; CD4+ T lymphocyte; cryptococcosis; Cryptococcus neoformans; cytokine release; endocytosis; endoplasmic reticulum stress; Filobasidiella; human; immune response; immune system; innate immunity; lung alveolus macrophage; macrophage; molecular interaction; mycosis; nonhuman; oxidative stress; phagocytosis; phagolysosome; Th17 cell |
Ministry of Education, Culture, Research and Technology of the Republic of Indonesia, (NKB-0395/UN2.R3.1/HKP.05.00/2019) |
This manuscript was supported by “Publikasi Internasional Terindeks Tugas Akhir (PITTA A)” Research Grant 2019 from the Ministry of Education, Culture, Research and Technology of the Republic of Indonesia with grant number NKB-0395/UN2.R3.1/HKP.05.00/2019 |
African Traditional, Herbal Medicine Supporters Initiative |
20060165 |
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Article |
Q4 |
184 |
20019 |
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21 |
Manurung M.A.; Umbas R.; Hamid A.R.A.H.; Mochtar C.A. |
Manurung, Mega Anara (58293043000); Umbas, Rainy (6602634832); Hamid, Agus Rizal A. H. (57202054669); Mochtar, Chaidir Arif (6506558321) |
58293043000; 6602634832; 57202054669; 6506558321 |
Penile carcinoma: A retrospective analysis of 93 patients at a tertiary care center in Jakarta, Indonesia |
2024 |
International Journal of Urology |
31 |
7 |
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764 |
770 |
6 |
2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85190892282&doi=10.1111%2fiju.15462&partnerID=40&md5=5701ee106fc9c117e0f66595713264e8 |
Department of Urology, Faculty of Medicine/Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Manurung M.A., Department of Urology, Faculty of Medicine/Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Umbas R., Department of Urology, Faculty of Medicine/Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Hamid A.R.A.H., Department of Urology, Faculty of Medicine/Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Mochtar C.A., Department of Urology, Faculty of Medicine/Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Objectives: Penile carcinoma (PC) is a rare disease with considerable physical and psychological impact. To date, there is no data regarding PC prevalence and characteristics in Indonesia. This study aimed to analyze the characteristics of patients with PC in Indonesia and determine cumulative survival rates and time to disease progression. Methods: This was a retrospective study of all patients diagnosed with PC at Cipto Mangunkusumo General Hospital from 1995 to 2014, with a minimum of 1 year follow-up. The outcomes of the study were cumulative survival rates and time-to-disease progression. Results: Ninety-three subjects were recruited, with a mean age of 49.44 ± 13.62. Inguinal lymph node dissection (ILND) was performed in 49 (53%) patients. The mean survival in the ILND group was better compared to the non-ILND group (80.7 months vs. 67.1 months; p = 0.032). Time-to-progression in the ILND group was significantly longer than in the non-ILND group (71.7 months vs. 54.3 months; p = 0.022). No significant difference in survival between the total and partial penectomy (PP) groups was observed (p = 0.701). Time-to-progression in total penectomy (TP) was significantly longer than in PP (68 months vs. 56.0 months; p = 0.023). In Cox-regression analysis, after adjustment of other variables, history of ILND, higher stage of cancer, and older age were found to affect the survival of patients. Conclusion: ILND in PC led to better survival and reduced disease progression. The type of penectomy is only associated with progression but not survival. TP had a longer time to disease progression compared to PP. © 2024 The Japanese Urological Association. |
inguinal lymph node dissection; penectomy; penile cancer; the survival rate; time to disease progression |
Adult; Aged; Carcinoma, Squamous Cell; Disease Progression; Follow-Up Studies; Humans; Indonesia; Lymph Node Excision; Male; Middle Aged; Penile Neoplasms; Retrospective Studies; Survival Rate; Tertiary Care Centers; adult; Article; cancer growth; cancer surgery; controlled study; follow up; histopathology; human; human tissue; Indonesia; inguinal lymph node; lymph node dissection; major clinical study; male; penis amputation; penis carcinoma; proportional hazards model; retrospective study; risk factor; surgical margin; survival analysis; survival rate; survival time; tertiary care center; aged; disease exacerbation; epidemiology; lymph node dissection; middle aged; mortality; pathology; penis tumor; squamous cell carcinoma; surgery; tertiary care center |
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John Wiley and Sons Inc |
9198172 |
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38641982 |
Article |
Q2 |
694 |
7174 |
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23 |
Sihombing I.N.N.; Arsianti A. |
Sihombing, Irene Natalia Nesta (59169674500); Arsianti, Ade (36124567000) |
59169674500; 36124567000 |
Network pharmacology prediction and molecular docking analysis on the mechanism of eugenol as a candidate against estrogen receptor-positive breast cancer |
2024 |
Journal of Pharmacy and Pharmacognosy Research |
12 |
5 |
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837 |
851 |
14 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85195793153&doi=10.56499%2fjppres23.1699_12.5.837&partnerID=40&md5=1249d5992c06de582fc5c5437957e3d9 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medicinal Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Sihombing I.N.N., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Arsianti A., Department of Medicinal Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Context: Breast cancer therapy currently presents several uncomfortable side effects in patients, including effects on non-malignant tissues, recurrence, and resistance, which restrict their utilization. Consequently, researchers have directed their attention toward studying plant-derived anticancer compounds that exhibit high efficacy and safety profiles. Eugenol, a major component found in clove plants, demonstrates promising potential as a therapeutic agent for both estrogen receptor-positive and estrogen receptor-negative breast cancer. Aims: To predict the target of eugenol in estrogen receptor positive breast cancer using network pharmacology and molecular docking analyses. Methods: Network pharmacology analysis was performed using the Chemical Toxigenomic Database, STITCH, GeneCards, Cytoscape, Enrichr, and Stringdb. Subsequently, molecular docking was performed using protein targets obtained from the RCSB-PDB and analyzed using AutoDock software. Results: Network pharmacology study and molecular docking revealed the anticancer effect of eugenol against breast cancer estrogen receptor positive, especially in cancer and apoptotic pathways, by acting on caspase-3 (CASP3), epidermal growth factor receptor (EGFR), and poly [ADP-ribose] polymerase 1 (PARP1) signaling pathways. The docking results between the protein targets and eugenol showed that eugenol has the strongest binding with CASP3 (ligand binding energy: -5.78 kcal/mol), followed by eugenol binding with EGFR (ligand binding energy: -5.58 kcal/mol), and eugenol binding with PARP1 (ligand binding energy: -5.58 kcal/mol). Conclusions: Eugenol is a potential candidate for breast cancer therapy, especially for apoptosis mediated by CASP3 in breast cancer luminal A. © 2024 Journal of Pharmacy & Pharmacognosy Research. |
breast cancer; eugenol; KEGG enrichment; molecular docking; network pharmacology |
caspase 3; epidermal growth factor receptor; estrogen receptor; eugenol; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase 1; antineoplastic activity; apoptosis; Article; cancer inhibition; estrogen receptor positive breast cancer; human; ligand binding; molecular docking; Protein Data Bank; signal transduction; systems pharmacology |
Universitas Indonesia, UI |
This study was supported by Hibah Publikasi Terindeks International (PUTI) Pascasarjana with appointment number NKB-125/UN2.RST/HKP.05.00/2022 of Universitas Indonesia, Indonesia. The authors would like to thank Universitas Indonesia for supporting our study. |
Academic Association of Pharmaceutical Sciences from Antofagasta (ASOCIFA) |
7194250 |
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Article |
Q2 |
312 |
14790 |
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24 |
Yunus R.E.; Sriyana A.A. |
Yunus, Reyhan E. (57215658457); Sriyana, Ayu A. (57203022550) |
57215658457; 57203022550 |
Unusual presentation of bilateral tuberculous otomastoiditis with tuberculous spondylitis in a 14-year-old child: A case report |
2024 |
Radiology Case Reports |
19 |
7 |
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2679 |
2683 |
4 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85190330097&doi=10.1016%2fj.radcr.2024.03.060&partnerID=40&md5=8c5c628ad56dee44ac1a56f94ae271b3 |
Department of Radiology, Dr. Cipto Mangunkusumo General Hospital-Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Department of Otorhinolaryngology, Head and Neck Surgery, Dr. Cipto Mangunkusumo General Hospital-Faculty of Medicine University of Indonesia, Jakarta, Indonesia |
Yunus R.E., Department of Radiology, Dr. Cipto Mangunkusumo General Hospital-Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Sriyana A.A., Department of Otorhinolaryngology, Head and Neck Surgery, Dr. Cipto Mangunkusumo General Hospital-Faculty of Medicine University of Indonesia, Jakarta, Indonesia |
Tuberculous otomastoiditis, a rare manifestation of tuberculosis in the head and neck region, poses diagnostic and therapeutic challenges due to its non-specific clinical features and potential debilitating complications. While typically arising from direct spread from adjacent organs, the coexistence of tuberculous otomastoiditis and cervical spondylitis is rarely reported. We present the case of a 14-year-old male with a 3-month history of painless bilateral ear discharge resistant to antibiotic therapy. The clinical and radiological findings raised suspicions of tuberculous otomastoiditis and spondylitis, which was later confirmed by histopathological examination despite negative microbiological cultures. This case underscores the significance of considering tuberculosis in conditions involving multiple organs, especially when persistent extensive damage is observed despite optimal initial treatments. © 2024 |
Children; Mastoiditis; Otitis media; Spondylitis; Tuberculosis |
tuberculostatic agent; abscess; adolescent; Article; bacterial arthritis; bilateral tuberculous otomastoiditis; case report; caseation; cervical lymphadenopathy; cervical spine radiography; clinical article; computer assisted tomography; ear edema; eardrum perforation; fifth cervical vertebra; fistula; granulomatous inflammation; hearing impairment; histopathology; human; human tissue; Langhans giant cell; male; mastoiditis; meningitis; neck pain; nuclear magnetic resonance imaging; osteomyelitis; otitis media; paravertebral abscess; physical examination; surgical debridement; tuberculosis; tuberculous spondylitis |
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Elsevier Inc. |
19300433 |
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Article |
Q4 |
226 |
17897 |
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27 |
Atmodiwirjo P.; Ramadan M.R.; Sapphira E.; Djohan M.; Ralena N.A.; Amanda N.F. |
Atmodiwirjo, Parintosa (57203016968); Ramadan, Mohamad R. (57222667572); Sapphira, Elrica (59213850300); Djohan, Michael (59205590300); Ralena, Nadhira A. (57214093149); Amanda, Nadira F. (59205390500) |
57203016968; 57222667572; 59213850300; 59205590300; 57214093149; 59205390500 |
Fluorescence Intensity between Standard versus Diluted Indocyanine Green to Evaluate Flap Perfusion in Rats |
2024 |
Plastic and Reconstructive Surgery - Global Open |
12 |
7 |
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e5948 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85198189408&doi=10.1097%2fGOX.0000000000005948&partnerID=40&md5=e878745493a992780d45de0fbaa4be30 |
Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Atmodiwirjo P., Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Ramadan M.R., Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Sapphira E., Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Djohan M., Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Ralena N.A., Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Amanda N.F., Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Summary: The ideal dose for indocyanine green (ICG) has not been established yet, although 5 mg per mL is widely accepted for free flap evaluation. Due to its high price and rarity in developing countries, this preliminary study aimed to find the lowest concentration of ICG without reducing the fluorescence quality read by near-infrared camera in animal models. An experimental study was conducted on 25 Wistar rats divided into five groups based on the injected ICG, which was in 5 mg per mL, 3.75 mg per mL, 2.5 mg per mL, 1.25 mg per mL, and 0.5 mg per mL concentrations. The epigastric flap was elevated and confirmed to be vital on the fifth day. Upon confirmation, bolus IV injection of ICG was given via the tail, and the flap was read using near-infrared camera. The 25 different videos are randomized and rated individually in a blind manner by five microsurgeons, chosen beforehand. The videos are evaluated with a scoring system ranging from 0 to 4, assessing fluorescence visibility and flap vasculature. Nonetheless, the intraclass correlation coefficient is 0.779. There was no difference between standard and diluted ICG concentrations to evaluate flap perfusion. The 2.5 mg per mL concentration of ICG was the most favorable. This finding is not clinically relevant for application in human subjects yet. However, this study shows promising results for further usage of ICG in daily practice at a lower cost. © 2024 Lippincott Williams and Wilkins. All rights reserved. |
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Lippincott Williams and Wilkins |
21697574 |
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Article |
Q2 |
671 |
7496 |
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