Per 30 Juni 2024 (499 artikel)

Riset dan Pengabdian Masyarakat Do Research Sosial Service and Innovation

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2	Chenderawasi S.; Dharma R.; Pohan H.T.; Dewi B.E.; Setiabudy R.; Suhendro; Aryati; Darmawan H.; Nainggolan L.; Iskandar A.	Chenderawasi, Settrin (57221643087); Dharma, Rahajuningsih (12777817700); Pohan, Herdiman T. (23474782900); Dewi, Beti Ernawati (24076058600); Setiabudy, Rianto (6602316235); Suhendro (57215086884); Aryati (57209860388); Darmawan, Hardi (8581795700); Nainggolan, Leonard (23498394800); Iskandar, Agustin (37079172000)	57221643087; 12777817700; 23474782900; 24076058600; 6602316235; 57215086884; 57209860388; 8581795700; 23498394800; 37079172000	Cut-off Value of HSPG for Early Marker of Plasma Leakage in Adult Dengue Patient	2024	Indonesian Journal of Clinical Pathology and Medical Laboratory	30	3		259	264	5	0	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85196512724&doi=10.24293%2fijcpml.v30i3.2221&partnerID=40&md5=c691867fc67c7f2904e3cec2a9cfba6b	Community-Based Dengue Study, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Clinical Pathology, University of Indonesia, Jakarta, Indonesia; Department of Internal Medicine, University of Indonesia, Jakarta, Indonesia; Department of Microbiology, University of Indonesia, Jakarta, Indonesia; Department of Pharmacology, University of Indonesia, Jakarta, Indonesia; Department of Clinical Pathology, Airlangga University, Surabaya, Indonesia; Department of Physiology, University of Sriwijaya, Palembang, Indonesia; Department of Clinical Pathology, Brawijaya University, Malang, Indonesia	Chenderawasi S., Community-Based Dengue Study, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Dharma R., Department of Clinical Pathology, University of Indonesia, Jakarta, Indonesia; Pohan H.T., Department of Internal Medicine, University of Indonesia, Jakarta, Indonesia; Dewi B.E., Community-Based Dengue Study, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Department of Microbiology, University of Indonesia, Jakarta, Indonesia; Setiabudy R., Department of Pharmacology, University of Indonesia, Jakarta, Indonesia; Suhendro, Department of Internal Medicine, University of Indonesia, Jakarta, Indonesia; Aryati, Department of Clinical Pathology, Airlangga University, Surabaya, Indonesia; Darmawan H., Department of Physiology, University of Sriwijaya, Palembang, Indonesia; Nainggolan L., Community-Based Dengue Study, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Department of Internal Medicine, University of Indonesia, Jakarta, Indonesia; Iskandar A., Department of Clinical Pathology, Brawijaya University, Malang, Indonesia	Plasma leakage is a state of increased vascular permeability due to loss of interendothelial junction and focal adhesion. Endothelium glycocalyx plays a major role in the pathogenesis of plasma leakage. Proteoglycans glycocalyx consists of heparan sulfate (HSPG) around 50-90%. Plasma leakage in dengue infection can be fatal and early detection is essential. This study aimed to determine the optimal cut-off value of HSPG levels for early marker of plasma leakage in dengue infection. The study was a retrospective cohort study as a part of the Community Based Dengue Study of the Faculty of Medicine, University of Indonesia, which was conducted between February 2010 and January 2011. Subjects were recruited by consecutive sampling. Dengue infection was confirmed by conventional PCR serotyping. Subjects were categorized into 2 groups, i.e. those with and without plasma leakage. Plasma leakage was confirmed by hemoconcentration or hypoalbuminemia or USG results. The level of HSPG was measured using the ELISA method from the first until the third day of the hospital admission. A total of 40 subjects were involved in this study, consisting of 21 with leakage and 19 without st nd leakage. The optimal cut-off level of HSPG as a marker of early plasma leakage in dengue infection patients on the 1 day, 2 rd day, and 3 day was was 2179.73 pg/mL, 2538.66 pg/mL, and 1294.06 pg/mL, respectively. HSPG could as an early marker of plasma leakage in dengue infection with an optimal cut-off value for each of the first 3 days of the patient's fever. A pediatric study was recommended to obtain the optimal cut-off value for HSPG. © 2024, Indonesian Association of Clinical Pathology and Laboratory Medicine. All rights reserved.	Dengue; HSPG; plasma leakage marker	Community Based Dengue Study Faculty of Medicine Universitas Indonesia	This study was supported by the Community Based Dengue Study Faculty of Medicine Universitas Indonesia.	Indonesian Association of Clinical Pathology and Laboratory Medicine	24774685		Article	#N/A	#N/A	#N/A	View
6	Soetisna T.W.; Thamrin A.M.H.; Ramadhani A.N.E.; Permadijana D.; Elfian M.A.; Hendarto H.	Soetisna, Tri Wisesa (57214887740); Thamrin, Ahmad Muslim Hidayat (58192261300); Ramadhani, Andi Nurul Erisya (58489887400); Permadijana, Diajeng (58492411600); Elfian, Muhammad Alghifari (59152843500); Hendarto, Hari (55206713900)	57214887740; 58192261300; 58489887400; 58492411600; 59152843500; 55206713900	Systematic Review of Stem Cell Therapy for Ischemic Heart Disease in Indonesia: Where Are We Now?	2024	Malaysian Journal of Medicine and Health Sciences	20	3		298	306	8	0	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85194956672&doi=10.47836%2fmjmhs.20.3.40&partnerID=40&md5=9142c7b56db0c3e4b8b7a22981bd7e4e	Adult Cardiac Surgery Division, Department of Thoracic and Cardiovascular Surgery, Harapan Kita National Cardiovascular Center Hospital, Jakarta, Indonesia; Faculty of Medicine Syarif Hidayatullah State Islamic University, Haji Hospital, Jakarta, Indonesia; Department of Thoracic and Cardiovascular Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia	Soetisna T.W., Adult Cardiac Surgery Division, Department of Thoracic and Cardiovascular Surgery, Harapan Kita National Cardiovascular Center Hospital, Jakarta, Indonesia, Faculty of Medicine Syarif Hidayatullah State Islamic University, Haji Hospital, Jakarta, Indonesia; Thamrin A.M.H., Adult Cardiac Surgery Division, Department of Thoracic and Cardiovascular Surgery, Harapan Kita National Cardiovascular Center Hospital, Jakarta, Indonesia, Department of Thoracic and Cardiovascular Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Ramadhani A.N.E., Adult Cardiac Surgery Division, Department of Thoracic and Cardiovascular Surgery, Harapan Kita National Cardiovascular Center Hospital, Jakarta, Indonesia; Permadijana D., Adult Cardiac Surgery Division, Department of Thoracic and Cardiovascular Surgery, Harapan Kita National Cardiovascular Center Hospital, Jakarta, Indonesia; Elfian M.A., Adult Cardiac Surgery Division, Department of Thoracic and Cardiovascular Surgery, Harapan Kita National Cardiovascular Center Hospital, Jakarta, Indonesia; Hendarto H., Department of Thoracic and Cardiovascular Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia	Introduction: Heart failure due to IHD is one of the most common causes of morbidity in Indonesia. The promising stem cell therapy for IHD patients has been conducted in Indonesia since 12 years ago but limited results of publications are available. We conducted a systematic review to evaluate the progress of stem cell therapy for IHD patients in Indonesia. Methods: A systematic review was conducted according to the PRISMA guidelines. A comprehensive literature search was performed using the PubMed, Scopus, and Embase databases from March – April 2023. Articles are thoroughly evaluated and analyzed. Results: Four publications from Indonesia related to stem cell therapy for IHD patients are included. Clinical outcome was measured by LVEF, WMSI, and 6-MWT. Safety outcomes are also measured. Follow-up time ranged from 6 – 12 months. Significant improvement in most of the LVEF, WMSI, and 6-MWT studies. Safety outcome measures demonstrated relatively low rates of AE after stem cell transplantation and no cardiac event-related deaths were reported. Conclusion: Stem cell therapy trials for IHD in Indonesia show promising results in improving ventricular function and daily functional outcomes safely. With the fast-growing trend of stem cells and cardiovascular centers in Indonesia, we hope that more well-designed clinical trials with long-term outcome assessments can be conducted to confirm these results. © 2024 Universiti Putra Malaysia Press. All rights reserved.	Indonesia; Ischemic heart disesase; Outcome; Safety; Sstem cell			Universiti Putra Malaysia Press	16758544		Article	Q4	139	22705	View
10	Amalia M.; Saputri F.C.; Sauriasari R.; Widyantoro B.	Amalia, Muttia (57201697619); Saputri, Fadlina Chany (45561842900); Sauriasari, Rani (16246507200); Widyantoro, Bambang (35286148600)	57201697619; 45561842900; 16246507200; 35286148600	Cholesterol low density lipoprotein associations with complete blood count parameters in atherosclerotic cardiovascular disease patients	2024	AIP Conference Proceedings	3155	1	030007				0	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85196498049&doi=10.1063%2f5.0218103&partnerID=40&md5=d5db89cbf03fdeda55e3adcd862fe364	Doctoral Program, Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Department of Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - National Cardiovascular Center, Harapan Kita, Jakarta, 11420, Indonesia	Amalia M., Doctoral Program, Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Saputri F.C., Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Sauriasari R., Department of Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Widyantoro B., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - National Cardiovascular Center, Harapan Kita, Jakarta, 11420, Indonesia	Cholesterol low density lipoprotein (LDL) is strongly associated with the development of atherosclerotic vascular disease (ASCVD). The objective of this study is to assess the relationships between cholesterol LDL and complete blood count (CBC) in ASCVD patients. This cross-sectional study was conducted at the National Cardiovascular Center Harapan Kita Jakarta. A total of 75 ASCVD patients from outpatient and emergency room departments were included in this study. The Chi-square test and the regression logistic analysis test were used to assess the relationships between cholesterol LDL and CBC. In this study, LDL level was found to be associated with the levels of leucocyte, percentage of eosinophil, percentage of lymphocyte, and absolute monocyte level. Lower eosinophil and lymphocyte levels were associated with increased LDL level. Regression logistic analysis revealed that the percentage of eosinophil (95%CI, 1.20 - 8.98; p value=0.02) and absolute monocyte (95%CI, 0.11 - 0.97; p value=0.04) were significant predictors of higher LDL levels in ASCVD. Increased inflammation due to elevated LDL may have resulted in circulating blood count alterations. Leucocytes and their differential count may aid in determining chronic inflammation and the progression of ASCVD. © 2024 Author(s).				American Institute of Physics	0094243X		Conference paper	-	164	21059	View
16	Prawiroharjo P.; Anggraini H.; Geraldi I.P.; Octaviana F.; Budikayanti A.; Safri A.Y.; Wiratman W.; Indrawati L.A.; Fadli N.; Harsono A.R.; Hakim M.	Prawiroharjo, Pukovisa (57195838668); Anggraini, Hikma (59124155100); Geraldi, Iskandar Purba (58116732300); Octaviana, Fitri (26029958700); Budikayanti, Astri (57194713932); Safri, Ahmad Yanuar (57091699300); Wiratman, Winnugroho (57191920526); Indrawati, Luh Ari (57205117182); Fadli, Nurul (58772486600); Harsono, Adrian Ridski (59011489600); Hakim, Manfaluthy (57216861859)	57195838668; 59124155100; 58116732300; 26029958700; 57194713932; 57091699300; 57191920526; 57205117182; 58772486600; 59011489600; 57216861859	Factors correlating to decisions for prescribing pharmacological treatment and referrals in suspected peripheral neuropathy cases in chat consultation-based application	2024	Heliyon	10	10	e30713				0	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85192934441&doi=10.1016%2fj.heliyon.2024.e30713&partnerID=40&md5=8df51869c2fab92bbe63df29c1ff5e0a	Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia; Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia; Department of Neurology, Universitas Indonesia Hospital, Indonesia	Prawiroharjo P., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia, Department of Neurology, Universitas Indonesia Hospital, Indonesia; Anggraini H., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia; Geraldi I.P., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia; Octaviana F., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia; Budikayanti A., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia; Safri A.Y., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia; Wiratman W., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia, Department of Neurology, Universitas Indonesia Hospital, Indonesia; Indrawati L.A., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia; Fadli N., Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia, Department of Neurology, Universitas Indonesia Hospital, Indonesia; Harsono A.R., Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia, Department of Neurology, Universitas Indonesia Hospital, Indonesia; Hakim M., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia	Introduction: Since the COVID-19 pandemic, there has been increasing use ofchat-based telemedicine, including for patients with neuropathy complaints. It is imperative to learn how to effectively use telemedicine. This study describes the characteristics of patients with neuropathy complaints in chat-based telemedicine services in Indonesia and their influence on treatment decisions and referrals. Methods: This is a retrospective cross-sectional study during the COVID-19 pandemic era (March 2020 to December 2021) using anonymous secondary data from patient chat databases on Indonesian application-based telemedicine services (Halodoc, Alodokter, Good Doctor, and Milvik). We applied bivariate and multivariate analysis. Results: We obtained 1051 patients with suspected peripheral nerve complaints (4 per 10,000) from a total of 2,199,527 user consultations, with the majority being 40–64 years old females and diabetes mellitus was the leading comorbid (90.7%). Most patients received treatment (90.7%) and only 11.4% patients were referred. Multivariate analysis showed that treatment was more likely to be given by a neurologist (p < 0.01). Chronic symptoms (p < 0.01) and previous laboratory/other tests (p = 0.01) decreased the likelihood of medication prescription. Referrals were more likely to be given to chronic onset (p = 0.02), hypertension and heart disease (p < 0.01), and previous laboratory/other tests (p = 0.02). The opposite was true for age≥65 years, female (p = 0.04), and neurologists or other specialists as responders (p < 0.01). Conclusion: We identified several factors that influence the treatment decision such as female patients and onset. Meanwhile, age, sex, chronic symptoms, history of hypertension and heart disease, and previous laboratory/other tests may influence the referral decisions. General practitioners were more likely to refer the patients whereas neurologists or other specialists were more likely to give treatment. Chat-based telemedicine services can still be developed in the future to be better. © 2024	Chat; Clinical decision making; Neuropathic pain; Neuropathy complaints; Paresthesia; Telemedicine			Elsevier Ltd	24058440		Article	Q1	609	8422	View
20	Rahman S.F.; Ghiffary M.M.; Tampubolon J.Y.; Yulianti E.S.; Nadhif M.H.; Katili P.A.; Hanafiah S.; Pangesty A.I.; Maras M.A.J.	Rahman, Siti Fauziyah (55440248200); Ghiffary, Muhammad Maulana (57927703300); Tampubolon, Joshua Yoshihiko (57894791800); Yulianti, Elly Septia (57222155918); Nadhif, Muhammad Hanif (57189057498); Katili, Puspita Anggraini (56608201800); Hanafiah, Siti (58996661000); Pangesty, Azizah Intan (57195717687); Maras, Muhammad Artha Jabatsudewa (57222618983)	55440248200; 57927703300; 57894791800; 57222155918; 57189057498; 56608201800; 58996661000; 57195717687; 57222618983	Effect of graphite, graphene oxide, and multi-walled carbon nanotubes on the physicochemical characteristics and biocompatibility of chitosan/hyaluronic acid/hydroxyapatite scaffolds for tissue engineering applications	2024	Journal of Science: Advanced Materials and Devices	9	2	100719				1	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85190975258&doi=10.1016%2fj.jsamd.2024.100719&partnerID=40&md5=f6a3d19f77acd631d93d2a48844b4f23	Division of Biomedical Engineering, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Medical Physiology and Biophysics Department, Faculty of Medicine, Universitas Indonesia, Kampus UI Salemba, Jakarta, 10430, Indonesia; Medical Technology Cluster, Indonesian Medical Education and Research Institute, Kampus UI Salemba, Jakarta, 10430, Indonesia; Botnar Research Institute, Nuffield Department of Orthopaedics and Musculoskeletal Sciences, University of Oxford, Oxford, OX3 7LD, United Kingdom; Department of Metallurgy and Material Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Biomedical Engineering, Institut Teknologi Sumatera, Lampung, 35365, Indonesia	Rahman S.F., Division of Biomedical Engineering, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Ghiffary M.M., Division of Biomedical Engineering, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Tampubolon J.Y., Division of Biomedical Engineering, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Yulianti E.S., Division of Biomedical Engineering, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Nadhif M.H., Medical Physiology and Biophysics Department, Faculty of Medicine, Universitas Indonesia, Kampus UI Salemba, Jakarta, 10430, Indonesia, Medical Technology Cluster, Indonesian Medical Education and Research Institute, Kampus UI Salemba, Jakarta, 10430, Indonesia, Botnar Research Institute, Nuffield Department of Orthopaedics and Musculoskeletal Sciences, University of Oxford, Oxford, OX3 7LD, United Kingdom; Katili P.A., Division of Biomedical Engineering, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Hanafiah S., Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Department of Metallurgy and Material Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Pangesty A.I., Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Department of Metallurgy and Material Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Maras M.A.J., Biomedical Engineering, Institut Teknologi Sumatera, Lampung, 35365, Indonesia	Bone tissue engineering (BTE) is a promising alternative approach to the repair of damaged bone tissue. This study aims to fabricate and characterize scaffolds composed of chitosan (CS), hyaluronic acid (HA), hydroxyapatite (HAp), and a combination of graphite (Gr), graphene oxide (GO), and multi-walled carbon nanotubes (MWCNT) for BTE applications. The Gr and MWCNT were functionalized by acid oxidation, while the GO was synthesized using the improved Hummers' method. The scaffolds were prepared by lyophilization, and the physical, chemical, and biological properties were evaluated. Scanning electron microscopy (SEM), energy-dispersive x-ray spectroscopy (EDS), Fourier transform infrared (FTIR) spectroscopy, mechanical testing, water contact angle, degradation, and biocompatibility assays were used to characterize the scaffolds. The degradation rate was determined using the liquid displacement method. Pores of different sizes were present on the surface of and throughout the scaffold. According to the FTIR results, the scaffolds contained functional groups that promote cell differentiation and proliferation. These scaffolds have compressive strength, Young's modulus, and toughness similar to cancellous bone, with reasonable porosity and controllable degradation rates. Biocompatibility testing confirmed that the scaffolds support cell proliferation and differentiation. © 2024 Vietnam National University, Hanoi	Biomaterials; Bone tissue engineering; Graphene oxide; Graphite; Multi-walled carbon nanotubes; Scaffold	UC-MSC	The CS/HA/HAp/GO scaffold contains GO, a material known for its scaffolding ability and bone-inducing properties. However, despite these favorable properties, the results indicated that proliferation in this scaffold was inferior to that in the CS/HA/HAp scaffold. This study showed that five of the eight materials demonstrated the ability to induce cell proliferation in culture with medium alone.	Elsevier B.V.	24682284		Article	Q1	1130	3425	View
22	Sunardi D.; Chandra D.N.; Medise B.E.; Manikam N.R.M.; Friska D.; Lestari W.; Insani P.N.C.	Sunardi, Diana (57192075078); Chandra, Dian Novita (57190861000); Medise, Bernie Endyarni (57226215370); Manikam, Nurul Ratna Mutu (56681219300); Friska, Dewi (57202805330); Lestari, Wiji (57222081857); Insani, Putri Novia Choiri (57565215500)	57192075078; 57190861000; 57226215370; 56681219300; 57202805330; 57222081857; 57565215500	Health effects of alkaline, oxygenated, and demineralized water compared to mineral water among healthy population: A systematic review	2024	Reviews on Environmental Health	39	2		339	349	10	1	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85145691207&doi=10.1515%2freveh-2022-0057&partnerID=40&md5=692a386f05aa8e9a2b0f8e4a89233b9b	Indonesian Hydration Working Group, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Child Health Department, Faculty of Medicine Universitas Indonesia, Dr.Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Occupational Medicine, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Sunardi D., Indonesian Hydration Working Group, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Chandra D.N., Indonesian Hydration Working Group, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Medise B.E., Indonesian Hydration Working Group, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Child Health Department, Faculty of Medicine Universitas Indonesia, Dr.Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Manikam N.R.M., Indonesian Hydration Working Group, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Friska D., Indonesian Hydration Working Group, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Occupational Medicine, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Lestari W., Indonesian Hydration Working Group, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Insani P.N.C., Indonesian Hydration Working Group, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Objectives: There are many water types available on the market. They are widely known in public with health claims. The questions are, are those claims are scientifically proven or those are just testimonies from the consumers or overclaimed by the producers. This study aims to systematically review evidences on the health effects of alkaline, oxygenated, and demineralized water in comparison with mineral water among healthy population. Contents: Data were obtained from databases PubMed, Cochrane, Scopus, EBSCO, dan Science Direct since January 2000 until July 2022. There were 10 eligible articles, consisted of two articles on alkaline, four articles on oxygenated, and four articles on demineralized water, that furtherly being analyzed. Summary: Compared to consumption of mineral water, consumption of alkaline and oxygenated water did not show any significant difference on gut microbiota, urine pH, blood parameter, or fitness parameter. While, consumption of demineralized water in the long term resulted in lower quality of certain nutrient intake. Outlook: Recent evidences do not prove any additional health effects of alkaline, oxygenated, or demineralized water compared to mineral water. In contrast, demineralized water consumption in the long run was proven to lead to adverse effect. © 2022 the author(s), published by De Gruyter, Berlin/Boston.	alkaline water; demineralized water; health benefit; mineral water; oxygenated water			Walter de Gruyter GmbH	00487554	36571558	Review	Q1	897	5023	View
29	Habiburrahman M.; Sutopo S.; Sarkowi W.K.	Habiburrahman, Muhammad (57204537114); Sutopo, Stefanus (57749107800); Sarkowi, Widya Khairunnisa (58485303400)	57204537114; 57749107800; 58485303400	Plausible use of citicoline as an adjuvant in central nervous system infections: A case report and review of the literature	2024	World Academy of Sciences Journal	6	4	e39				0	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85195882024&doi=10.3892%2fwasj.2024.254&partnerID=40&md5=dc2840fd07b17d5dc90d220da79c121a	Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, 10430, Indonesia; Dr. Cipto Mangunkusumo Hospital, Central Jakarta, DKI Jakarta, 10430, Indonesia; Tebet Subdistrict Public Hospital, South Jakarta, DKI Jakarta, 12810, Indonesia; Faculty of Medicine, Imperial College London, London, SW7 2AZ, United Kingdom; School of Infection and Immunity, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, United Kingdom; Faculty of Medicine, IPB University, West Java, Bogor, 16680, Indonesia; Faculty of Medicine, Universitas Indonesia, Salemba Raya Street No. 6, Senen Subdistrict, Central Jakarta, DKI Jakarta, 10430, Indonesia	Habiburrahman M., Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, 10430, Indonesia, Dr. Cipto Mangunkusumo Hospital, Central Jakarta, DKI Jakarta, 10430, Indonesia, Tebet Subdistrict Public Hospital, South Jakarta, DKI Jakarta, 12810, Indonesia, Faculty of Medicine, Imperial College London, London, SW7 2AZ, United Kingdom, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street No. 6, Senen Subdistrict, Central Jakarta, DKI Jakarta, 10430, Indonesia; Sutopo S., Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, 10430, Indonesia, Dr. Cipto Mangunkusumo Hospital, Central Jakarta, DKI Jakarta, 10430, Indonesia, School of Infection and Immunity, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, United Kingdom, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street No. 6, Senen Subdistrict, Central Jakarta, DKI Jakarta, 10430, Indonesia; Sarkowi W.K., Faculty of Medicine, Imperial College London, London, SW7 2AZ, United Kingdom, Faculty of Medicine, IPB University, West Java, Bogor, 16680, Indonesia	Citicoline has been widely used for the treatment of neurological conditions of the central nervous system (CNS), and exhibit potential for infection management, providing anti-inflammatory, antiviral, antioxidant and neuroprotective properties. The present study describes the case of a 50-year-old male patient co-infected with suspected tuberculosis and COVID-19 affecting the CNS who was treated with citicoline. The study aimed to raise clinical questions and initiate a comprehensive literature review. It also aimed to explore the plausible benefits of the use of citicoline in restoring consciousness and alleviating neurological symptoms in CNS infections. In the literature review, eight studies, including two quasi-experimental studies, five literature reviews, and one case report were found to be relevant to the case of the patient described herein, and they suggested that citicoline demonstrated partial protection against cerebral malaria, prevented encephalitis sequelae when immediately administered, and inhibited coronavirus replication. Additionally, six studies reported the potential of citicoline in the treatment of neurological conditions, such as ethambutol-induced optic neuropathy, stroke, head trauma and CNS infections caused by cerebral malaria and COVID-19, compared to standard therapy. Citicoline shows promise as an adjuvant therapy for neurological complications associated with CNS infections. © 2024 Spandidos Publications. All rights reserved.	adjuvant therapy; central nervous system infections; citicoline; evidence-based case report; neurological disorders			Spandidos Publications	26322900		Article	Q3	317	14612	View
37	Saputri S.; Alodia B.; Habiburrahman M.	Saputri, Silvana (57212475016); Alodia, Beryl (57208311898); Habiburrahman, Muhammad (57204537114)	57212475016; 57208311898; 57204537114	Neonatal hyperglycaemia in extremely preterm and extremely low birth weight infants: A report of a rare case and a review of the literature	2024	World Academy of Sciences Journal	6	4	37				0	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85195862140&doi=10.3892%2fwasj.2024.252&partnerID=40&md5=ad838e867e6357a5aa840aaf3a45bfd1	Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, 10430, Indonesia; Dr. Cipto Mangunkusumo Hospital, Central Jakarta, DKI Jakarta, 10430, Indonesia; Bunda Mother and Child Hospital, Central Jakarta, DKI Jakarta, 10350, Indonesia; Community Health Centre Mampang Prapatan, South Jakarta, DKI Jakarta, 12720, Indonesia; Faculty of Medicine, Imperial College London, London, SW7 2AZ, United Kingdom	Saputri S., Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, 10430, Indonesia, Dr. Cipto Mangunkusumo Hospital, Central Jakarta, DKI Jakarta, 10430, Indonesia, Bunda Mother and Child Hospital, Central Jakarta, DKI Jakarta, 10350, Indonesia; Alodia B., Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, 10430, Indonesia, Dr. Cipto Mangunkusumo Hospital, Central Jakarta, DKI Jakarta, 10430, Indonesia, Community Health Centre Mampang Prapatan, South Jakarta, DKI Jakarta, 12720, Indonesia; Habiburrahman M., Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, 10430, Indonesia, Dr. Cipto Mangunkusumo Hospital, Central Jakarta, DKI Jakarta, 10430, Indonesia, Faculty of Medicine, Imperial College London, London, SW7 2AZ, United Kingdom	Neonatal hyperglycaemia poses risks, and the efficacy of insulin therapy is uncertain, warranting comprehensive research and guidelines. The present study reports the case of an extremely preterm neonate with an extremely low birth weight (ELBW; <1,000 g) admitted to the neonatal intensive care unit (NICU) due to recurrent hyperglycaemic episodes (peak level, 465 mg/dl) with transient hypoglycaemia on the first day of life. The mother, a 31-year-old primiparous woman, had gestational hypertension and preeclampsia, resulting in neonatal distress at birth and the need for positive pressure ventilation for stabilisation. The condition of the baby remained stable in the NICU following resuscitation. The case described herein details the management of a neonate facing multiple stresses and metabolic challenges, including grade IV hyaline membrane disease, grade II necrotising enterocolitis and a patent foramen ovale with good heart contractility. The initial laboratory findings revealed pancytopenia. At 1 h of life, the neonate experienced hypoglycaemia (33 mg/dl), treated with a 10% bolus dextrose infusion and continuous parenteral nutrition. Glucose infusion rate (GIR) adjustments followed local guidelines. Cardiovascular support with dobutamine and dopamine addressed the low blood pressure. Subsequently, the neonate developed hyperglycaemia, requiring insulin therapy and GIR adjustments. By close monitoring and promptly intervening, the authors were able to achieve stable blood glucose levels using insulin boluses (0.1 U) and adjusting the GIR to 10.9 mg/kg body weight (BW)/min. Stable glycaemia was attained by the 4th day prior to referral, with a GIR of 12.4 mg/kg BW/min. The case in the present study highlights the challenges of managing extremely preterm infants with ELBW and emphasises effective resuscitation and NICU interventions. It was hypothesised that her refractory hyperglycaemia was caused by her underlying extremely premature neonatal condition, including inadequate insulin response, gluconeogenesis, reduced glucose transporter levels, insufficient protein intake affecting insulin-like growth factor-1 release, immature pancreas development and stress-related hormonal responses. © 2024 Spandidos Publications. All rights reserved.	clinical outcomes; extremely low birth weight; hypoglycaemia; neonatal hyperglycaemia; premature			Spandidos Publications	26322900		Article	Q3	317	14612	View
43	Kurniawan R.; Taslim N.A.; Hardinsyah H.; Syauki A.Y.; Idris I.; Aman A.M.; Permatasari H.K.; Wiyarta E.; Surya R.; Mayulu N.; Putra P.P.; Tjandrawinata R.R.; Tallei T.E.; Kim B.; Tsopmo A.; Nurkolis F.	Kurniawan, Rudy (57990353000); Taslim, Nurpudji Astuti (57194571794); Hardinsyah, Hardinsyah (56586054400); Syauki, Andi Yasmin (57376214300); Idris, Irfan (16636857800); Aman, Andi Makbul (57193706169); Permatasari, Happy Kurnia (57194728338); Wiyarta, Elvan (57221521342); Surya, Reggie (56610805600); Mayulu, Nelly (57303104200); Putra, Purnawan Pontana (57222390016); Tjandrawinata, Raymond Rubianto (6603266135); Tallei, Trina Ekawati (57193317686); Kim, Bonglee (51663469700); Tsopmo, Apollinai	57990353000; 57194571794; 56586054400; 57376214300; 16636857800; 57193706169; 57194728338; 57221521342; 56610805600; 57303104200; 57222390016; 6603266135; 57193317686; 51663469700; 6602260089; 57226728465	Pharmacoinformatics and cellular studies of algal peptides as functional molecules to modulate type-2 diabetes markers	2024	Future Foods	9		100354				0	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85191446983&doi=10.1016%2fj.fufo.2024.100354&partnerID=40&md5=7ba8790954696285f27694dbeba70fd5	Graduate from School of Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Diabetes Connection Care, Eka Hospital Bumi Serpong Damai, Tangerang, 15321, Indonesia; Division of Clinical Nutrition, Department of Nutrition, Faculty of Medicine, Hasanuddin University, Makassar, 90245, Indonesia; Division of Applied Nutrition, Faculty of Human Ecology, Department of Community Nutrition, IPB University, Bogor, Indonesia; Department of Physiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Makassar, Indonesia; Department of Biochemistry and Biomolecular, Faculty of Medicine, University of Brawijaya, Malang, 65145, Indonesia; Department of Neurology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Hospital, Jakarta, 10430, Indonesia; Department of Food Technology, Faculty of Engineering, Bina Nusantara University, Jakarta, 11480, Indonesia; Department of Nutrition, Faculty of Health Science, Muhammadiyah Manado University, Manado, 95249, Indonesia; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Andalas, Padang, 25163, Indonesia; Department of Biotechnology, Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta, 12930, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, 95115, Indonesia; Department of Pathology, College of Korean Medicine, Kyung Hee University, Kyungheedae-Ro 26, Dong-Daemun-Gu, Seoul, 05254, South Korea; Food Science and Nutrition Program, Department of Chemistry, Carleton University, 1125 Colonel by Drive, Ottawa, ON K1S 5B6, Canada; Department of Biological Sciences, Faculty of Sciences and Technology, State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga), Yogyakarta, 55281, Indonesia	Kurniawan R., Graduate from School of Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia, Diabetes Connection Care, Eka Hospital Bumi Serpong Damai, Tangerang, 15321, Indonesia; Taslim N.A., Division of Clinical Nutrition, Department of Nutrition, Faculty of Medicine, Hasanuddin University, Makassar, 90245, Indonesia; Hardinsyah H., Division of Applied Nutrition, Faculty of Human Ecology, Department of Community Nutrition, IPB University, Bogor, Indonesia; Syauki A.Y., Division of Clinical Nutrition, Department of Nutrition, Faculty of Medicine, Hasanuddin University, Makassar, 90245, Indonesia; Idris I., Department of Physiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Aman A.M., Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Makassar, Indonesia; Permatasari H.K., Department of Biochemistry and Biomolecular, Faculty of Medicine, University of Brawijaya, Malang, 65145, Indonesia; Wiyarta E., Department of Neurology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Hospital, Jakarta, 10430, Indonesia; Surya R., Department of Food Technology, Faculty of Engineering, Bina Nusantara University, Jakarta, 11480, Indonesia; Mayulu N., Department of Nutrition, Faculty of Health Science, Muhammadiyah Manado University, Manado, 95249, Indonesia; Putra P.P., Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Andalas, Padang, 25163, Indonesia; Tjandrawinata R.R., Department of Biotechnology, Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta, 12930, Indonesia; Tallei T.E., Department of Biology, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, 95115, Indonesia; Kim B., Department of Pathology, College of Korean Medicine, Kyung Hee University, Kyungheedae-Ro 26, Dong-Daemun-Gu, Seoul, 05254, South Korea; Tsopmo A., Food Science and Nutrition Program, Department of Chemistry, Carleton University, 1125 Colonel by Drive, Ottawa, ON K1S 5B6, Canada; Nurkolis F., Department of Biological Sciences, Faculty of Sciences and Technology, State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga), Yogyakarta, 55281, Indonesia	Novel dietary strategies are urgently needed to address the limitations of current management and treatment options of Type-2 Diabetes (T2D). Marine algae-derived peptides (MAP) represent a promising avenue, although, their potential remains mostly underexplored. This study employs pharmacoinformatics and in vitro methods to evaluate the antidiabetic properties of MAP and provide new insights their mechanisms to mitigate the prevalence of T2D. Through a systematic search and predictive modeling, peptides were identified and assessed for bioactivity, toxicity, and drug-likeness. Furthermore, molecular docking simulations with protein targets related to T2D identified binding sites that be used to optimize the activity of MAP. The structure-activity relationship profile of MAP reveals 13 candidates with probable activity (Pa) scores >0.4, indicative of insulin promoter. The peptide FDGIP (P13;Phe-Asp-Gly-Ile-Pro) from Caulerpa lentillifera had the best in silico assessment value compared to 50 other peptides and its activity was confirmed by in vitro data (e.g.EC50 60.4 and 57.9 for α-amylase and α-glucosidase inhibitions). Interestingly, in 3T3-L1 cells, P13 exhibited inhibitory activities against transcription factors and hormones (MAPK8-JNK1/PPARGC1A/Ghrelin/GLP-1/CPT-1) that can regulate blood sugar and decrease as anti-diabetes. P13 then appears to be a peptide with antidiabetic action that may be used in the formulation foods to manage T2D. © 2024 The Author(s)	Algae; Diabetes; Functional food; MAPK8; Marine peptide; Metabolic syndrome			Elsevier B.V.	26668335		Article	Q1	682	7352	View
48	Rukminiati Y.; Mesak F.; Lolong D.; Sudarmono P.	Rukminiati, Yuni (57214868942); Mesak, Felix (59184897200); Lolong, Dina (36802094400); Sudarmono, Pratiwi (6507855437)	57214868942; 59184897200; 36802094400; 6507855437	First Indonesian report of WGS-based MTBC L3 discovery	2024	BMC Research Notes	17	1	176				0	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85196761698&doi=10.1186%2fs13104-024-06825-5&partnerID=40&md5=7629841e16668b833b73b6365f0c6a07	Doctoral Program in Biomedical Sciences, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; National Laboratory of Prof Sri Oemijati, Ministry of Health of the Republic of Indonesia, Jakarta, Indonesia; National Research and Innovation Agency, Jakarta, Indonesia; Department of Clinical Microbiology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia	Rukminiati Y., Doctoral Program in Biomedical Sciences, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, National Laboratory of Prof Sri Oemijati, Ministry of Health of the Republic of Indonesia, Jakarta, Indonesia; Mesak F., Doctoral Program in Biomedical Sciences, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Lolong D., National Research and Innovation Agency, Jakarta, Indonesia; Sudarmono P., Department of Clinical Microbiology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia	Objective: Recent spoligotyping results in the island nation of Indonesia had revealed the existence of Mycobacterium tuberculosis complex lineage 3 (MTBC L3) or Central Asian (CAS) strains. In this work, whole-genome sequencing (WGS) – based methods were used to search for the presence of MTBC L3. Results: Two unrelated Indonesian L3 strains discovered by WGS-based SNP phylogenomics are presented here for the first time. Assemblies of their genomes yielded 96.95% (MTBC strain Mtb_S6970) and 98.35% (Mtb_S19106) of the known reference strain H37Rv. Their respective constructed genome coverages are 45.38 ± 12.95x and 63.13 ± 21.10x. The two L3 genomes have 4062 and 4121 genes, respectively, which are well within the number of genes predicted in MTBC strains. Instead of having three rRNA genes usually, Mtb_S6970 possesses four. These L3 isolates exhibit cross-class antibiotic susceptibility. FadD26, fadE24, fbpA, lprO, and panC, which are thought to be important in the pathophysiology of MTBC, were discovered to have 3–7 times more loci in L3 than L2 or L4. The penetration of L3 in the nation, despite its antibiotic sensitivity, is a concerning indicator of borderless global spread that may eventually be overcome by the phenotypes of acquired drug resistance. © The Author(s) 2024.	Phylogenomic; Tuberculosis; Whole genome sequencing	NIHRD; Laboratorium Terpadu FKUI; IRCCS San Raffaele Scientific Institute; TB Alliance	Funding text 1: The authors would like to thank everyone at NIHRD of MoH, FKUI\u2019s LMK, Laboratorium Terpadu FKUI, HUMRC Makassar, BBLK Makassar, and BBLK Surabaya who supplied samples and clinical data to this study. We would also like to thank Andrea M. Cabbibe and Arash Goudoshi from IRCCS San Raffaele Scientific Institute, Tuberculosis Supranational Reference Laboratory in Milan for their a	BioMed Central Ltd	17560500		Article	Q2	534	9718	View

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