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Khudri G.; Sukmawati D. |
Khudri, Ghaniyyatul (59154919100); Sukmawati, Dewi (55615650900) |
59154919100; 55615650900 |
Exploring hematopoietic stem cell population in human milk and its benefits for infants: A scoping review |
2024 |
Asian Pacific Journal of Reproduction |
13 |
3 |
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107 |
114 |
7 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85195080927&doi=10.4103%2fapjr.apjr_108_23&partnerID=40&md5=ccb5b4e1c6fb2a637aebbc0d8043d031 |
Department of Histology, Faculty of Medicine, Universitas Baiturrahmah, Padang, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Khudri G., Department of Histology, Faculty of Medicine, Universitas Baiturrahmah, Padang, Indonesia; Sukmawati D., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Objective: To comprehensively explore hematopoietic stem cells (HSCs) in human milk, understanding their molecular markers, isolation methods, benefits for infants, and potential medical applications. Methods: We conducted a scoping literature review following the PRISMA-ScR guidelines. This review included studies investigating HSCs in human milk, utilizing molecular markers such as CD34 +, CD113 +, and CD117 + for characterization. Both in vitro and in vivo studies exploring the morphology, function, and clinical implications of these cells were considered. The diverse range of papers reviewed were indexed in PubMed, Science Direct, Scopus, Sage Journals, and Google Scholar, published between 2010 and 2023. Results: This scoping review explored 577 articles and selected 13 studies based on our inclusion criteria, focusing on HSCs in human milk. Most studies dilute samples prior to HSC isolation, followed by detection using markers such as CD34 +, CD113 +, and CD117 +, with flow cytometry serving as the primary analysis tool, focusing on their isolation and detection methods. While no definitive benefits have been conclusively established, there is a strong belief in the potential of HSCs to positively impact infant immunity, growth, and tissue repair. Conclusions: This review presents significant evidence supporting the presence of HSCs in human milk, identified by markers such as CD34 +, CD113 +, and CD117 +. These cells show considerable potential in enhancing infant health, including immunity, tissue repair, cognitive development, and gastrointestinal health. Despite methodological variations in isolation and detection techniques, the collective findings underscore the potential clinical relevance of HSCs in human milk. Moreover, this review highlights the non-invasive accessibility of human milk as a source of HSCs and emphasizes the need for further research to unlock their therapeutic potential. © 2024 Asian Pacific Journal of Reproduction. |
CD34 +; Cellular components; Hematopoietic stem cells; Human milk; Stem cells |
cd113 antigen; CD133 antigen; CD34 antigen; lymphocyte antigen; octamer transcription factor 4; receptor type tyrosine protein phosphatase C; stem cell factor receptor; Thy 1 membrane glycoprotein; transcription factor NANOG; transcription factor Sox2; unclassified drug; breast milk; cell culture; cell function; cell isolation; cell population; cell structure; child health; cognition; flow cytometry; hematopoietic stem cell; human; immunocytochemistry; immunofluorescence assay; in vitro study; in vivo study; kangaroo care; lactocyte; myoepithelium cell; passive immunization; Preferred Reporting Items for Systematic Reviews and Meta-Analyses; real time reverse transcription polymerase chain reaction; Review; stem cell; systematic review; tooth development |
National Research and Innovation Agency of Republic of Indonesia; Badan Riset dan Inovasi Nasional, BRIN; Institute of Education Fund Management; Lembaga Pengelola Dana Pendidikan, LPDP |
This study is supported by the National Research and Innovation Agency of Republic of Indonesia (BRIN) - RIIM Batch-2 2022 research grants and the Institute of Education Fund Management (Lembaga Pengelola Dana Pendidikan - LPDP). |
Wolters Kluwer Medknow Publications |
23050500 |
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Review |
Q3 |
191 |
19638 |
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2 |
Chenderawasi S.; Dharma R.; Pohan H.T.; Dewi B.E.; Setiabudy R.; Suhendro; Aryati; Darmawan H.; Nainggolan L.; Iskandar A. |
Chenderawasi, Settrin (57221643087); Dharma, Rahajuningsih (12777817700); Pohan, Herdiman T. (23474782900); Dewi, Beti Ernawati (24076058600); Setiabudy, Rianto (6602316235); Suhendro (57215086884); Aryati (57209860388); Darmawan, Hardi (8581795700); Nainggolan, Leonard (23498394800); Iskandar, Agustin (37079172000) |
57221643087; 12777817700; 23474782900; 24076058600; 6602316235; 57215086884; 57209860388; 8581795700; 23498394800; 37079172000 |
Cut-off Value of HSPG for Early Marker of Plasma Leakage in Adult Dengue Patient |
2024 |
Indonesian Journal of Clinical Pathology and Medical Laboratory |
30 |
3 |
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259 |
264 |
5 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85196512724&doi=10.24293%2fijcpml.v30i3.2221&partnerID=40&md5=c691867fc67c7f2904e3cec2a9cfba6b |
Community-Based Dengue Study, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Clinical Pathology, University of Indonesia, Jakarta, Indonesia; Department of Internal Medicine, University of Indonesia, Jakarta, Indonesia; Department of Microbiology, University of Indonesia, Jakarta, Indonesia; Department of Pharmacology, University of Indonesia, Jakarta, Indonesia; Department of Clinical Pathology, Airlangga University, Surabaya, Indonesia; Department of Physiology, University of Sriwijaya, Palembang, Indonesia; Department of Clinical Pathology, Brawijaya University, Malang, Indonesia |
Chenderawasi S., Community-Based Dengue Study, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Dharma R., Department of Clinical Pathology, University of Indonesia, Jakarta, Indonesia; Pohan H.T., Department of Internal Medicine, University of Indonesia, Jakarta, Indonesia; Dewi B.E., Community-Based Dengue Study, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Department of Microbiology, University of Indonesia, Jakarta, Indonesia; Setiabudy R., Department of Pharmacology, University of Indonesia, Jakarta, Indonesia; Suhendro, Department of Internal Medicine, University of Indonesia, Jakarta, Indonesia; Aryati, Department of Clinical Pathology, Airlangga University, Surabaya, Indonesia; Darmawan H., Department of Physiology, University of Sriwijaya, Palembang, Indonesia; Nainggolan L., Community-Based Dengue Study, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Department of Internal Medicine, University of Indonesia, Jakarta, Indonesia; Iskandar A., Department of Clinical Pathology, Brawijaya University, Malang, Indonesia |
Plasma leakage is a state of increased vascular permeability due to loss of interendothelial junction and focal adhesion. Endothelium glycocalyx plays a major role in the pathogenesis of plasma leakage. Proteoglycans glycocalyx consists of heparan sulfate (HSPG) around 50-90%. Plasma leakage in dengue infection can be fatal and early detection is essential. This study aimed to determine the optimal cut-off value of HSPG levels for early marker of plasma leakage in dengue infection. The study was a retrospective cohort study as a part of the Community Based Dengue Study of the Faculty of Medicine, University of Indonesia, which was conducted between February 2010 and January 2011. Subjects were recruited by consecutive sampling. Dengue infection was confirmed by conventional PCR serotyping. Subjects were categorized into 2 groups, i.e. those with and without plasma leakage. Plasma leakage was confirmed by hemoconcentration or hypoalbuminemia or USG results. The level of HSPG was measured using the ELISA method from the first until the third day of the hospital admission. A total of 40 subjects were involved in this study, consisting of 21 with leakage and 19 without st nd leakage. The optimal cut-off level of HSPG as a marker of early plasma leakage in dengue infection patients on the 1 day, 2 rd day, and 3 day was was 2179.73 pg/mL, 2538.66 pg/mL, and 1294.06 pg/mL, respectively. HSPG could as an early marker of plasma leakage in dengue infection with an optimal cut-off value for each of the first 3 days of the patient's fever. A pediatric study was recommended to obtain the optimal cut-off value for HSPG. © 2024, Indonesian Association of Clinical Pathology and Laboratory Medicine. All rights reserved. |
Dengue; HSPG; plasma leakage marker |
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Community Based Dengue Study Faculty of Medicine Universitas Indonesia |
This study was supported by the Community Based Dengue Study Faculty of Medicine Universitas Indonesia. |
Indonesian Association of Clinical Pathology and Laboratory Medicine |
24774685 |
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Article |
#N/A |
#N/A |
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3 |
Syahrani L.; Asih P.B.S.; Bowolaksono A.; Dwiranti A.; Zubaidah S.; Rozi I.E.; Permana D.H.; Bøgh C.; Bangs M.J.; Grieco J.P.; Achee N.L.; Lobo N.F.; Syafruddin D. |
Syahrani, Lepa (55014440600); Asih, Puji B. S. (6507080729); Bowolaksono, Anom (57205093224); Dwiranti, Astari (55151437900); Zubaidah, Siti (57216572364); Rozi, Ismail E. (57193863994); Permana, Dendi H. (57218188245); Bøgh, Claus (6602120205); Bangs, Michael J. (7007079698); Grieco, John P. (7003422533); Achee, Nicole L. (6603480149); Lobo, Neil F. (35392948100); Syafruddin, Din (6602774565) |
55014440600; 6507080729; 57205093224; 55151437900; 57216572364; 57193863994; 57218188245; 6602120205; 7007079698; 7003422533; 6603480149; 35392948100; 6602774565 |
Impact of a spatial repellent intervention on Anopheles kdr insecticide resistance allele in Sumba, Indonesia |
2024 |
Malaria Journal |
23 |
1 |
31 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85182828683&doi=10.1186%2fs12936-024-04841-1&partnerID=40&md5=d012e123af603ec236833d76ef429e7e |
Doctoral Program, Department of Biology, Faculty of Mathematics and Natural Sciences, University of Indonesia, Depok, Indonesia; Eijkman Research Center for Molecular Biology, National Research and Innovation Agency (BRIN), Cibinong, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, University of Indonesia, Depok, Indonesia; Doctoral Program, Faculty of Medicine, University of Hasanuddin, Makassar, Indonesia; Doctoral Program of Biomedical Sciences, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; The Sumba Foundation, Public Health and Malaria Control, Sumba, Indonesia; Public Health and Malaria Control, PT Freeport Indonesia, International SOS, Mimika, Indonesia; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, IN, United States; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Hasanuddin University Medical Research Center (HUMRC), Makassar, Indonesia |
Syahrani L., Doctoral Program, Department of Biology, Faculty of Mathematics and Natural Sciences, University of Indonesia, Depok, Indonesia, Eijkman Research Center for Molecular Biology, National Research and Innovation Agency (BRIN), Cibinong, Indonesia; Asih P.B.S., Eijkman Research Center for Molecular Biology, National Research and Innovation Agency (BRIN), Cibinong, Indonesia; Bowolaksono A., Department of Biology, Faculty of Mathematics and Natural Sciences, University of Indonesia, Depok, Indonesia; Dwiranti A., Department of Biology, Faculty of Mathematics and Natural Sciences, University of Indonesia, Depok, Indonesia; Zubaidah S., Eijkman Research Center for Molecular Biology, National Research and Innovation Agency (BRIN), Cibinong, Indonesia; Rozi I.E., Eijkman Research Center for Molecular Biology, National Research and Innovation Agency (BRIN), Cibinong, Indonesia, Doctoral Program, Faculty of Medicine, University of Hasanuddin, Makassar, Indonesia; Permana D.H., Eijkman Research Center for Molecular Biology, National Research and Innovation Agency (BRIN), Cibinong, Indonesia, Doctoral Program of Biomedical Sciences, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Bøgh C., The Sumba Foundation, Public Health and Malaria Control, Sumba, Indonesia; Bangs M.J., Public Health and Malaria Control, PT Freeport Indonesia, International SOS, Mimika, Indonesia; Grieco J.P., Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, IN, United States; Achee N.L., Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, IN, United States; Lobo N.F., Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, IN, United States; Syafruddin D., Eijkman Research Center for Molecular Biology, National Research and Innovation Agency (BRIN), Cibinong, Indonesia, Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia, Hasanuddin University Medical Research Center (HUMRC), Makassar, Indonesia |
Background: The emergence of insecticide resistance and outdoor transmission in malaria-endemic areas underlines the urgent need to develop innovative tools, such as spatial repellents (SR), that may circumvent this residual transmission. With limited options for effective insecticides, regular resistance monitoring is warranted for selecting and using appropriate tools. This study evaluates the pyrethroid knockdown resistance (kdr) allele before and after implementing a transfluthrin-based spatial repellent (SR) intervention in placebo-treated clusters. Methods: This study looks at the frequency distribution of the kdr allele in Sumba Island from June 2015 to August 2018. Insecticide susceptibility tests were carried out on female Anopheles sp. aged 3–5 days against permethrin 21.5 μg/ml, deltamethrin 12.5 μg/ml, and transfluthrin 10 μg/ml using CDC bottle assay. PCR sequencing of representative samples from adult mosquito collections and insecticide tests revealed the presence of kdr mutations (L1014F and L1014S) in the VGSC gene. Results: A total of 12 Anopheles species, Anopheles tesselatus, Anopheles. aconitus, Anopheles barbirostris, Anopheles kochi, Anopheles annularis, Anopheles maculatus, Anopheles sundaicus, Anopheles flavirostris, Anopheles balabacensis, Anopheles indefinitus, Anopheles subpictus, and Anopheles vagus were analysed. Anopheles vagus and An. sundaicus predominated in the larval populations. Susceptibility assays for all insecticides identified fully susceptible phenotypes in all species examined. Anopheles increasing frequency of kdr mutant alleles during the 3 year SR deployment was observed in both SR-treated and placebo areas, a statistically significant increase occurred in each arm. However, it is unclear how significant SR is in causing the increase in mutant alleles. The L1014S, knockdown resistance east type (kdr-e) allele was detected for the first time among the mosquito samples in this study. The L1014F, knockdown resistance west type (kdr-w) allele and heteroduplex form (wild-type—mutant) were found in almost all Anopheles species examined, including An. vagus, An. aconitus, An. subpictus, An. tesselatus, An. annularis, An. flavirostris and An. sundaicus. Conclusion: The presence of fully susceptible phenotypes over time, along with an increase in the frequency distribution of the L1014F/S mutations post-intervention, suggest drivers of resistance external to the study, including pyrethroid use in agriculture and long-lasting insecticidal nets (LLINs). However, this does not negate possible SR impacts that support resistance. More studies that enable the comprehension of possible SR-based drivers of resistance in mosquitoes need to be conducted. © 2024, The Author(s). |
Kdr; L1014F; L1014S; Pyrethroid; Resistance; VGSC |
Alleles; Animals; Anopheles; Cyclopropanes; Female; Fluorobenzenes; Indonesia; Insecticide Resistance; Insecticides; Permethrin; deltamethrin; insect repellent; permethrin; placebo; transfluthrin; unclassified drug; cyclopropane derivative; fluorobenzene; insecticide; transfluthrin; allele; Anopheles; Anopheles annularis; Anopheles balabacensis; Anopheles barbirostris; Anopheles flavirostris; Anopheles indefinitus; Anopheles kochi; Anopheles maculatus; Anopheles subpictus; Anopheles sundaicus; Anopheles tesselatus; Anopheles vagus; Anopheles. aconitus; Article; controlled study; gene; gene frequency; gene knockdown; gene mutation; genetic susceptibility; Indonesia; insecticide resistance; kdr gene; nonhuman; phenotype; polymerase chain reaction; spatial analysis; allele; animal; female; ge |
District health departments of Southwest and West Sumba; East Nusa Tenggara Province; Eijkman Research Center for Molecular Biology; Government of Indonesia National Research and Innovation Agency; Health Research Organization; Bill and Melinda Gates Foundation, BMGF; University of Notre Dame, ND, (OPP1081737); Badan Riset dan Inovasi Nasional, BRIN; Universitas Hasanuddin; Ministry of Health of the Republic of Indonesia |
Funding text 1: The authors are grateful for the support of the Eijkman Research Center for Molecular Biology, National Research and Innovation Agency (BRIN), Cibinong, Indonesia; The University of Hasanuddin, Makassar, Indonesia; the Ministry of Health Republic of Indonesia; District health departments of Southwest and West Sumba, and East Nusa Tenggara Province. We appreciate the contribution of |
BioMed Central Ltd |
14752875 |
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38254131 |
Article |
Q1 |
1237 |
2935 |
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4 |
Rahayu D.; Meutia A.P.; Priyatini T.; Suratih N.M.D.; Maidarti M.; Harzif A.K.; Muharam R.; Pratama G. |
Rahayu, Deniswari (57208300474); Meutia, Alfa Putri (57203368133); Priyatini, Tyas (57192265423); Suratih, Ni Made Desy (26634582200); Maidarti, Mila (56320510400); Harzif, Achmad Kemal (57191493435); Muharam, R. (57191492732); Pratama, Gita (58162878900) |
57208300474; 57203368133; 57192265423; 26634582200; 56320510400; 57191493435; 57191492732; 58162878900 |
Association of hirsutism and anthropometric profiles with sexual dysfunction and anxiety levels in infertile Indonesian women with polycystic ovarian syndrome |
2024 |
Middle East Fertility Society Journal |
29 |
1 |
19 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85189636536&doi=10.1186%2fs43043-024-00178-6&partnerID=40&md5=22df206c1e005692cbf08891765f633a |
Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Urogynecology and Reconstructive Pelvic Surgery Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Reproductive Endocrinology Division, Department of Obstetrics and Gynecology, Persahabatan General Hospital, Jakarta, Indonesia; Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Yasmin IVF Clinic Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Rahayu D., Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Meutia A.P., Urogynecology and Reconstructive Pelvic Surgery Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Priyatini T., Urogynecology and Reconstructive Pelvic Surgery Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Suratih N.M.D., Reproductive Endocrinology Division, Department of Obstetrics and Gynecology, Persahabatan General Hospital, Jakarta, Indonesia; Maidarti M., Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Yasmin IVF Clinic Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Harzif A.K., Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Yasmin IVF Clinic Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Muharam R., Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Yasmin IVF Clinic Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Pratama G., Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Yasmin IVF Clinic Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Background: Hyperandrogenism is frequently found in polycystic ovary syndrome (PCOS) and contributes to physical manifestations like hirsutism and obesity, along with infertility. This condition can result in anxiety, depression, and body image disorders, potentially leading to sexual dysfunction. The objective of this investigation was to assess the correlation among hirsutism, anthropometric characteristics, sexual dysfunction, and anxiety levels among infertile Indonesian women diagnosed with PCOS. Methods: From December 2021 to December 2022, a cross-sectional study was undertaken involving 71 infertile women diagnosed with PCOS at Yasmin Clinic, Dr. Cipto Mangunkusumo General Hospital in Jakarta, Indonesia. Hirsutism was assessed using the modified Ferriman-Gallwey (mFG) score; the anthropometric profile was assessed using BMI and waist-to-hip ratio. The assessment of sexual dysfunction was conducted using the Female Sexual Function Index (FSFI) questionnaire, while the evaluation of anxiety levels utilized the HAM-A questionnaires. Results: In this study, it was discovered that 53.3% of subjects experienced sexual dysfunction. However, there was no statistically significant relationship between hirsutism, anthropometric profile, and sexual dysfunction score in infertile women with PCOS (p > 0.05). Analysis of the overall FSFI domain score revealed that lubrication and satisfaction were lower in obese patients (p = 0.02 and p = 0.03), but this did not contribute to an overall sexual dysfunction score. Also, we found that subjects who experienced sexual dysfunction had a higher anxiety score (p < 0.005), with correlation analysis showing that Ferriman-Gallwey (FG) scores have a significant positive correlation with anxiety. Conclusion: There is no correlation between hirsutism, anthropometric profile, and sexual dysfunction in infertile Indonesian women diagnosed with PCOS. However, hirsutism could play a role in causing anxiety in Indonesian PCOS women. Additional investigation is required, as female sexual function is an intricate subject. © The Author(s) 2024. |
Anthropometric profile; Hyperandrogenism; Infertility; PCOS; Polycystic ovarian syndrome; Sexual dysfunction |
contraceptive agent; follitropin; luteinizing hormone; adult; anthropometric parameters; anxiety disorder; arousal; Article; automation; body height; body mass; body weight; correlational study; cross-sectional study; dyspareunia; educational status; employee; employment status; female; female infertility; Female Sexual Function Index; Hamilton Anxiety Scale; hip circumference; hirsutism; human; hyperandrogenism; Indonesian; intra-abdominal fat; laboratory test; lubrication; major clinical study; modified ferriman gallwey score; obese patient; obesity; orgasm; ovary polycystic disease; patient satisfaction; pleasure; prevalence; questionnaire; sexual dysfunction; sexual function; skin disease assessment; social status; subcutaneous fat; transvaginal echography; unemployment; waist circumfe |
Indonesian Reproductive Medicine Research and Training Center; INAREPROMED; PUTI Saintekes 2020, (NKB-2278/UN.2) |
Funding text 1: The authors express gratitude to the Indonesian Reproductive Medicine Research and Training Center (INAREPROMED) and the teams at Yasmin Clinic and Rumah Sakit Dr. Cipto Mangunkusumo Hospital for their invaluable assistance and support throughout this study.; Funding text 2: This study received funding from the PUTI Saintekes 2020 grant, contract number NKB-2278/UN.2.RST/HKP.05.00. |
Springer Science and Business Media Deutschland GmbH |
11105690 |
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Article |
Q3 |
322 |
14459 |
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5 |
Agung F.H.; Sekartini R.; Sudarsono N.C.; Hendarto A.; Werdhani R.A.; Pudjiati S.R.; Hanum L.; Naufal A.; Sawyer S.M. |
Agung, Fransisca Handy (36488930100); Sekartini, Rini (50162572300); Sudarsono, Nani Cahyani (57201862518); Hendarto, Aryono (57204142249); Werdhani, Retno Asti (57189088848); Pudjiati, Sri Retno (58909932500); Hanum, Lathifah (55606285800); Naufal, Affan (58766280400); Sawyer, Susan M (7103253172) |
36488930100; 50162572300; 57201862518; 57204142249; 57189088848; 58909932500; 55606285800; 58766280400; 7103253172 |
Development and validation of the adolescent behavioural change Counselling Assessment Tool in Indonesia |
2024 |
BMC Health Services Research |
24 |
1 |
257 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85186205298&doi=10.1186%2fs12913-024-10582-3&partnerID=40&md5=a579a3309c366dc68cb6f5c74e72efe3 |
Faculty of Medicine, Universitas Pelita Harapan, Jl. Jend. Sudirman No.20, Bencongan, Kelapa Dua, Tangerang, Banten, 15810, Indonesia; Department of Child Health, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jl. Salemba Raya No.6 Jakarta Pusat, Jakarta, 10430, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6 Jakarta Pusat, Jakarta, 10430, Indonesia; Faculty of Psychology, Universitas Indonesia, Kampus UI, West Java, Depok, Indonesia; Balaraja Distric Hospital, Jl. Rumah Sakit No 88, Balaraja, Tangerang, Banten, Indonesia; Centre for Adolescent Health, Royal Children’s Hospital and Murdoch Children’s Research Institute, Department of Paediatrics, The University of Melbourne, 50 Flemington Rd, Parkville, 3052, VIC, Australia |
Agung F.H., Faculty of Medicine, Universitas Pelita Harapan, Jl. Jend. Sudirman No.20, Bencongan, Kelapa Dua, Tangerang, Banten, 15810, Indonesia; Sekartini R., Department of Child Health, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jl. Salemba Raya No.6 Jakarta Pusat, Jakarta, 10430, Indonesia; Sudarsono N.C., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6 Jakarta Pusat, Jakarta, 10430, Indonesia; Hendarto A., Department of Child Health, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jl. Salemba Raya No.6 Jakarta Pusat, Jakarta, 10430, Indonesia; Werdhani R.A., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6 Jakarta Pusat, Jakarta, 10430, Indonesia; Pudjiati S.R., Faculty of Psychology, Universitas Indonesia, Kampus UI, West Java, Depok, Indonesia; Hanum L., Faculty of Psychology, Universitas Indonesia, Kampus UI, West Java, Depok, Indonesia; Naufal A., Balaraja Distric Hospital, Jl. Rumah Sakit No 88, Balaraja, Tangerang, Banten, Indonesia; Sawyer S.M., Centre for Adolescent Health, Royal Children’s Hospital and Murdoch Children’s Research Institute, Department of Paediatrics, The University of Melbourne, 50 Flemington Rd, Parkville, 3052, VIC, Australia |
Background: Primary care provides an important context to engage adolescents and their families in healthy lifestyles with the goal of reducing future behaviour-related health problems. Developing a valid tool to assess health professionals’ skills in behavioural change counselling is integral to improving the quality of clinical care provided to adolescents in Indonesia. Methods: This work was nested within a project to develop a training program to enhance the behaviour-change counselling of adolescents and their parents by Indonesian primary care professionals. Initial item development was based on the content of the training module and the domain structure of the Behavioral Change Counselling Index (BECCI), a commonly used tool to assess counselling quality in healthcare settings. Expert panels were used to test content validity, while face validity was assessed by a group of trained psychologists. Inter-rater agreement was calculated prior to tests of construct validity and reliability, which involved psychologists rating 125 audio-taped counselling sessions between the health professional and adolescent patients, together with a parent. Results: An initial 13-item tool was developed using a 1–5 Likert scale. Validity and reliability testing resulted in the decision to use a 14-item tool with a 0–3 Likert scale. The scale was found to have a Cronbach’s α coefficient of 0.839 (internal consistency), and there was strong inter-rater agreement (0.931). Conclusion: The assessment tool known as the Adolescent Behavioural Change Counselling Assessment Tool, is a valid and reliable instrument to measure Indonesian health professionals’ behavioural-change counselling skills with adolescent patients. The tool provides an evaluation framework for future interventions that aim to improve health professionals’ skills in addressing adolescent behaviour-related health problems. © The Author(s) 2024. |
Adolescent; Behaviour-change; Counselling skill; Health professionals; Non-communicable diseases; Quality |
Adolescent; Counseling; Delivery of Health Care; Health Behavior; Humans; Indonesia; Psychometrics; Reproducibility of Results; Surveys and Questionnaires; adolescent; counseling; health behavior; health care delivery; human; Indonesia; psychometry; questionnaire; reproducibility |
Maternal Health; Universitas Indonesia, UI, (00/2022, NKB–434/UN2, RST/ HKP.05); Ministry of Health of the Republic of Indonesia |
Funding text 1: The authors thank the Ministry of Health of the Republic of Indonesia, especially the director and the staff of The Directorate of Nutrition, Child and Maternal Health, the provincial health offices from 17 provinces and the clinical psychology team whose expertise greatly contributed to this assessment tool (Dian Oriza, Annisa Rahmalia, Utari Krisnamurthi, Sri Wulandari, Fina Dwi |
BioMed Central Ltd |
14726963 |
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38419005 |
Article |
Q1 |
964 |
4472 |
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6 |
Soetisna T.W.; Thamrin A.M.H.; Ramadhani A.N.E.; Permadijana D.; Elfian M.A.; Hendarto H. |
Soetisna, Tri Wisesa (57214887740); Thamrin, Ahmad Muslim Hidayat (58192261300); Ramadhani, Andi Nurul Erisya (58489887400); Permadijana, Diajeng (58492411600); Elfian, Muhammad Alghifari (59152843500); Hendarto, Hari (55206713900) |
57214887740; 58192261300; 58489887400; 58492411600; 59152843500; 55206713900 |
Systematic Review of Stem Cell Therapy for Ischemic Heart Disease in Indonesia: Where Are We Now? |
2024 |
Malaysian Journal of Medicine and Health Sciences |
20 |
3 |
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298 |
306 |
8 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85194956672&doi=10.47836%2fmjmhs.20.3.40&partnerID=40&md5=9142c7b56db0c3e4b8b7a22981bd7e4e |
Adult Cardiac Surgery Division, Department of Thoracic and Cardiovascular Surgery, Harapan Kita National Cardiovascular Center Hospital, Jakarta, Indonesia; Faculty of Medicine Syarif Hidayatullah State Islamic University, Haji Hospital, Jakarta, Indonesia; Department of Thoracic and Cardiovascular Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Soetisna T.W., Adult Cardiac Surgery Division, Department of Thoracic and Cardiovascular Surgery, Harapan Kita National Cardiovascular Center Hospital, Jakarta, Indonesia, Faculty of Medicine Syarif Hidayatullah State Islamic University, Haji Hospital, Jakarta, Indonesia; Thamrin A.M.H., Adult Cardiac Surgery Division, Department of Thoracic and Cardiovascular Surgery, Harapan Kita National Cardiovascular Center Hospital, Jakarta, Indonesia, Department of Thoracic and Cardiovascular Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Ramadhani A.N.E., Adult Cardiac Surgery Division, Department of Thoracic and Cardiovascular Surgery, Harapan Kita National Cardiovascular Center Hospital, Jakarta, Indonesia; Permadijana D., Adult Cardiac Surgery Division, Department of Thoracic and Cardiovascular Surgery, Harapan Kita National Cardiovascular Center Hospital, Jakarta, Indonesia; Elfian M.A., Adult Cardiac Surgery Division, Department of Thoracic and Cardiovascular Surgery, Harapan Kita National Cardiovascular Center Hospital, Jakarta, Indonesia; Hendarto H., Department of Thoracic and Cardiovascular Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Introduction: Heart failure due to IHD is one of the most common causes of morbidity in Indonesia. The promising stem cell therapy for IHD patients has been conducted in Indonesia since 12 years ago but limited results of publications are available. We conducted a systematic review to evaluate the progress of stem cell therapy for IHD patients in Indonesia. Methods: A systematic review was conducted according to the PRISMA guidelines. A comprehensive literature search was performed using the PubMed, Scopus, and Embase databases from March – April 2023. Articles are thoroughly evaluated and analyzed. Results: Four publications from Indonesia related to stem cell therapy for IHD patients are included. Clinical outcome was measured by LVEF, WMSI, and 6-MWT. Safety outcomes are also measured. Follow-up time ranged from 6 – 12 months. Significant improvement in most of the LVEF, WMSI, and 6-MWT studies. Safety outcome measures demonstrated relatively low rates of AE after stem cell transplantation and no cardiac event-related deaths were reported. Conclusion: Stem cell therapy trials for IHD in Indonesia show promising results in improving ventricular function and daily functional outcomes safely. With the fast-growing trend of stem cells and cardiovascular centers in Indonesia, we hope that more well-designed clinical trials with long-term outcome assessments can be conducted to confirm these results. © 2024 Universiti Putra Malaysia Press. All rights reserved. |
Indonesia; Ischemic heart disesase; Outcome; Safety; Sstem cell |
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Universiti Putra Malaysia Press |
16758544 |
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Article |
Q4 |
139 |
22705 |
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7 |
Lubis A.M.T.; Prasetyo J.; Canintika A.F. |
Lubis, Andri Maruli Tua (15122639800); Prasetyo, Joseph (59002254800); Canintika, Anissa Feby (57208821931) |
15122639800; 59002254800; 57208821931 |
Isolated posterior cruciate ligament tears in monozygotic twins: A case report |
2024 |
International Journal of Surgery Case Reports |
119 |
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109682 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85191328847&doi=10.1016%2fj.ijscr.2024.109682&partnerID=40&md5=0972bb4f235ecada673c2cd82a8c8625 |
Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Lubis A.M.T., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Prasetyo J., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Canintika A.F., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction and importance: Posterior cruciate ligament (PCL) tears are not as frequent as anterior cruciate ligament (ACL) tears. They are rare as an isolated injury and more commonly occur in a multi-ligament-injured knee. We reported a case of rupture of PCL in monozygotic twins. Case presentation: A 19-year-old female presented with giving away of her left knee since 4 months ago. She fell from stairs previously. Physical examination demonstrated positive posterior drawer test. Magnetic resonance imaging showed ruptured PCL and lateral meniscal tear. Two months later, her identical twin, also a 19-year old-female, fell from the stairs and complained of giving away. Physical examination showed positive posterior drawer test. Magnetic resonance imaging demonstrated ruptured PCL and lateral meniscal tear. Both patients underwent arthroscopic-assisted PCL reconstruction using gracilis, semitendinosus, and peroneus tendon graft. At one year of follow-up, there were no graft failures. The twins had satisfactory outcome measured by Osteoarthritis Outcome Score (KOOS) and visual analogue scale (VAS). Both were athletes prior to their injury and they returned to sport. Clinical discussion: Although it has never been reported before, this report shows that patients may have genetic predisposition to the incidence of PCL rupture. This is likely because of heritable factors, such as biomechanical, anatomic, anthropometric, and neuromuscular traits. A family history of PCL tear may increase the risk of a PCL tear. Further studies are recommended to examine genetic variants as a risk factor for PCL tears and other knee disorders. Conclusions: Multiple variables may lead to the increased risk of these twins: the combination of improper neuromuscular control, genetic factors, and possibly hormonal factors contributed to their PCL injuries. Further history exploration, lab tests, and genetic analysis should be done to determine the variables. Both patients returned to sports protocol testing and returned to sports one year postoperatively. © 2024 |
Monozygotic twins; Posterior cruciate ligament tear |
adult; arthroscopic surgery; Article; athlete; case report; clinical article; female; follow up; gracilis muscle; human; Knee Injury and Osteoarthritis Outcome Score; knee meniscus rupture; lateral meniscus; monozygotic twins; nuclear magnetic resonance imaging; peroneal muscle; physical examination; posterior cruciate ligament reconstruction; posterior cruciate ligament rupture; quadriceps femoris muscle; return to sport; semitendinous muscle; tendon graft; visual analog scale; young adult |
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Elsevier Ltd |
22102612 |
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Article |
Q3 |
193 |
19555 |
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8 |
Kurniawan J.; Teressa M.; Budiman R.A.; Matondang S.B.R.E. |
Kurniawan, Juferdy (57193251655); Teressa, Maria (57957998500); Budiman, Refael Alfa (57224981676); Matondang, Sahat Basana Romanti Ezer (57192085914) |
57193251655; 57957998500; 57224981676; 57192085914 |
Transarterial embolization with bleomycin–lipiodol emulsion: a successful minimal invasive approach for giant liver hemangioma |
2024 |
Clinical Journal of Gastroenterology |
17 |
3 |
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511 |
514 |
3 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85188537891&doi=10.1007%2fs12328-024-01948-5&partnerID=40&md5=c4c65b2e468658770d3f506ee3cefed8 |
Division of Hepatobiliary, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia; Department of Radiology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Kurniawan J., Division of Hepatobiliary, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia; Teressa M., Division of Hepatobiliary, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia; Budiman R.A., Division of Hepatobiliary, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia; Matondang S.B.R.E., Department of Radiology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Hemangiomas are most common benign liver tumor. Most patients have an excellent prognosis because of the small size and benign nature of tumor. On some occasions, giant liver hemangioma may cause symptoms and significant challenges due to its complication. We report a case of giant liver hemangioma treated with minimal invasive approach by transarterial embolization (TAE). Following three TAE sessions over a specific timeframe, the patient was successfully managed, addressing that TAE may be a useful alternative to hepatic surgery in such cases. © Japanese Society of Gastroenterology 2024. |
Giant hemangioma; Liver hemangioma; TAE; Transarterial embolization |
Antibiotics, Antineoplastic; Bleomycin; Chemoembolization, Therapeutic; Embolization, Therapeutic; Emulsions; Ethiodized Oil; Female; Hemangioma; Humans; Liver Neoplasms; Male; Middle Aged; alanine aminotransferase; aspartate aminotransferase; bleomycin; iodinated poppyseed oil; nuclear magnetic resonance imaging agent; proton pump inhibitor; antineoplastic antibiotic; bleomycin; iodinated poppyseed oil; abdominal discomfort; adult; Article; artificial embolization; bloating; body weight loss; case report; clinical article; female; fever; human; liver hemangioma; middle aged; minimally invasive surgery; nuclear magnetic resonance imaging; physical examination; chemoembolization; diagnostic imaging; emulsion; hemangioma; liver tumor; male; procedures; therapy |
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Springer |
18657257 |
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38526803 |
Article |
Q3 |
302 |
15057 |
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9 |
Fedrizal F.F.; Wijaya I.P.; Abdullah M.; Yamin M. |
Fedrizal, Fenandri Fadillah (57219280233); Wijaya, Ika Prasetya (57193731572); Abdullah, Murdani (7103393434); Yamin, Muhammad (23475706300) |
57219280233; 57193731572; 7103393434; 23475706300 |
Elevated neutrophyl-to-lymphocyte ratioand smoking are associated with chronic total occlusion in patients with ST elevation myocardial infarction |
2024 |
BMC Cardiovascular Disorders |
24 |
1 |
12 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85181244917&doi=10.1186%2fs12872-023-03680-3&partnerID=40&md5=9aaf3c2915cdc2583c57f09d4d1e5b80 |
Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Unit Epidemiology, Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Fedrizal F.F., Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Wijaya I.P., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Abdullah M., Unit Epidemiology, Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Yamin M., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Background: Atherosclerosis is a progressive disease characterized by the build-up of lipids and connective tissue in the large arteries. Some patients experience chronic total occlusion (CTO). Inflammation plays a key role in the development and complications of atherosclerosis. Neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation associated with the development of acute coronary syndrome (ACS). We aimed to assess the relationship between NLR and CTO in ACS patients with ST elevated myocardial infarction (STEMI) in Indonesia. Methods: This cross-sectional study was performed with secondary data obtained from patient medical records at Cipto Mangunkusumo National Central Hospital, Jakarta. Inclusion criteria were patients with ACS and STEMI who underwent coronary angiography in 2015–2018. Results: A total of 98 patients were enrolled in the analysis. Most subjects with CTO were male, elderly (> 60), smoking, had no history of diabetes mellitus (DM) or hypertension, no family history of coronary heart disease (CHD), but had a history of ACS and had never consumed statin or antiplatelet medications. Bivariate logistic regression analysis revealed that male gender (PR = 1.820; 95%CI 0.871–3.805; p = 0.025) and smoking (PR = 1.781; 95%CI 1.028–3.086; p = 0.004) were significantly correlated with CTO. Receiver operator characteristic (ROC) curve revealed that higher NLR (≥ 6.42) could predict a CTO diagnosis with positive predictive value (PPV) of 91%. Multivariate analysis revealed that NLR was correlated with an 11.2-fold increase in occurrence of CTO (95%CI 3.250-38.303; p < 0.001). Additionally, smoking was correlated with a 7-fold increase in CTO (95% CI 1.791–30.508; p = 0.006). Conclusion: NLR value of ≥ 6.42 is potentially useful as a marker of CTO in STEMI patients. In addition, smoking increases the risk of CTO in ACS/STEMI patients. © 2023, The Author(s). |
Chronic total occlusion; Coronary angiography; Coronary artery Disease; Myocardial Infarction; Neutrophil-to-lymphocyte ratio |
Acute Coronary Syndrome; Aged; Atherosclerosis; Chronic Disease; Coronary Occlusion; Cross-Sectional Studies; Female; Humans; Inflammation; Lymphocytes; Male; Percutaneous Coronary Intervention; Smoking; ST Elevation Myocardial Infarction; Treatment Outcome; antithrombocytic agent; hydroxymethylglutaryl coenzyme A reductase inhibitor; acute coronary syndrome; adult; age; aged; Article; bivariate analysis; cardiovascular risk; chronic total occlusion; controlled study; coronary angiography; cross-sectional study; diabetes mellitus; diagnostic test accuracy study; disease association; female; human; hypertension; Indonesia; ischemic heart disease; logistic regression analysis; major clinical study; male; medical record; multivariate analysis; neutrophil lymphocyte ratio; predictive value; re |
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BioMed Central Ltd |
14712261 |
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38172732 |
Article |
Q2 |
601 |
8561 |
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10 |
Amalia M.; Saputri F.C.; Sauriasari R.; Widyantoro B. |
Amalia, Muttia (57201697619); Saputri, Fadlina Chany (45561842900); Sauriasari, Rani (16246507200); Widyantoro, Bambang (35286148600) |
57201697619; 45561842900; 16246507200; 35286148600 |
Cholesterol low density lipoprotein associations with complete blood count parameters in atherosclerotic cardiovascular disease patients |
2024 |
AIP Conference Proceedings |
3155 |
1 |
030007 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85196498049&doi=10.1063%2f5.0218103&partnerID=40&md5=d5db89cbf03fdeda55e3adcd862fe364 |
Doctoral Program, Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Department of Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - National Cardiovascular Center, Harapan Kita, Jakarta, 11420, Indonesia |
Amalia M., Doctoral Program, Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Saputri F.C., Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Sauriasari R., Department of Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Widyantoro B., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - National Cardiovascular Center, Harapan Kita, Jakarta, 11420, Indonesia |
Cholesterol low density lipoprotein (LDL) is strongly associated with the development of atherosclerotic vascular disease (ASCVD). The objective of this study is to assess the relationships between cholesterol LDL and complete blood count (CBC) in ASCVD patients. This cross-sectional study was conducted at the National Cardiovascular Center Harapan Kita Jakarta. A total of 75 ASCVD patients from outpatient and emergency room departments were included in this study. The Chi-square test and the regression logistic analysis test were used to assess the relationships between cholesterol LDL and CBC. In this study, LDL level was found to be associated with the levels of leucocyte, percentage of eosinophil, percentage of lymphocyte, and absolute monocyte level. Lower eosinophil and lymphocyte levels were associated with increased LDL level. Regression logistic analysis revealed that the percentage of eosinophil (95%CI, 1.20 - 8.98; p value=0.02) and absolute monocyte (95%CI, 0.11 - 0.97; p value=0.04) were significant predictors of higher LDL levels in ASCVD. Increased inflammation due to elevated LDL may have resulted in circulating blood count alterations. Leucocytes and their differential count may aid in determining chronic inflammation and the progression of ASCVD. © 2024 Author(s). |
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American Institute of Physics |
0094243X |
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Conference paper |
- |
164 |
21059 |
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