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7 |
Lubis A.M.T.; Prasetyo J.; Canintika A.F. |
Lubis, Andri Maruli Tua (15122639800); Prasetyo, Joseph (59002254800); Canintika, Anissa Feby (57208821931) |
15122639800; 59002254800; 57208821931 |
Isolated posterior cruciate ligament tears in monozygotic twins: A case report |
2024 |
International Journal of Surgery Case Reports |
119 |
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109682 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85191328847&doi=10.1016%2fj.ijscr.2024.109682&partnerID=40&md5=0972bb4f235ecada673c2cd82a8c8625 |
Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Lubis A.M.T., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Prasetyo J., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Canintika A.F., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction and importance: Posterior cruciate ligament (PCL) tears are not as frequent as anterior cruciate ligament (ACL) tears. They are rare as an isolated injury and more commonly occur in a multi-ligament-injured knee. We reported a case of rupture of PCL in monozygotic twins. Case presentation: A 19-year-old female presented with giving away of her left knee since 4 months ago. She fell from stairs previously. Physical examination demonstrated positive posterior drawer test. Magnetic resonance imaging showed ruptured PCL and lateral meniscal tear. Two months later, her identical twin, also a 19-year old-female, fell from the stairs and complained of giving away. Physical examination showed positive posterior drawer test. Magnetic resonance imaging demonstrated ruptured PCL and lateral meniscal tear. Both patients underwent arthroscopic-assisted PCL reconstruction using gracilis, semitendinosus, and peroneus tendon graft. At one year of follow-up, there were no graft failures. The twins had satisfactory outcome measured by Osteoarthritis Outcome Score (KOOS) and visual analogue scale (VAS). Both were athletes prior to their injury and they returned to sport. Clinical discussion: Although it has never been reported before, this report shows that patients may have genetic predisposition to the incidence of PCL rupture. This is likely because of heritable factors, such as biomechanical, anatomic, anthropometric, and neuromuscular traits. A family history of PCL tear may increase the risk of a PCL tear. Further studies are recommended to examine genetic variants as a risk factor for PCL tears and other knee disorders. Conclusions: Multiple variables may lead to the increased risk of these twins: the combination of improper neuromuscular control, genetic factors, and possibly hormonal factors contributed to their PCL injuries. Further history exploration, lab tests, and genetic analysis should be done to determine the variables. Both patients returned to sports protocol testing and returned to sports one year postoperatively. © 2024 |
Monozygotic twins; Posterior cruciate ligament tear |
adult; arthroscopic surgery; Article; athlete; case report; clinical article; female; follow up; gracilis muscle; human; Knee Injury and Osteoarthritis Outcome Score; knee meniscus rupture; lateral meniscus; monozygotic twins; nuclear magnetic resonance imaging; peroneal muscle; physical examination; posterior cruciate ligament reconstruction; posterior cruciate ligament rupture; quadriceps femoris muscle; return to sport; semitendinous muscle; tendon graft; visual analog scale; young adult |
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Elsevier Ltd |
22102612 |
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Article |
Q3 |
193 |
19555 |
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26 |
Siregar G.O.; Harianja M.; Adella J.; Krismawati H.; Sundari E.S.; Ataupah M.R.; Laiskodat R.D.; Bøgh C.; Soebono H.; Grijsen M.L. |
Siregar, Gladys O. (58876649500); Harianja, Maria (58876435800); Adella, Jacklyn (58994793100); Krismawati, Hana (56572770100); Sundari, Evivana S. (58876435900); Ataupah, Messe R. (58993911900); Laiskodat, Ruth D. (58994354700); Bøgh, Claus (6602120205); Soebono, Hardyanto (6508242918); Grijsen, Marlous L. (25225113700) |
58876649500; 58876435800; 58994793100; 56572770100; 58876435900; 58993911900; 58994354700; 6602120205; 6508242918; 25225113700 |
Leprosy identified in Sumba Island, eastern Indonesia: elimination targets under threat |
2024 |
The Lancet Regional Health - Southeast Asia |
26 |
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100409 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85190856063&doi=10.1016%2fj.lansea.2024.100409&partnerID=40&md5=4f24b635df4260f90f0d5f674d9efa33 |
Sumba Foundation, Sumba, Indonesia; Center of Health System and Strategy, Ministry of Health, Jakarta, Indonesia; Department of Dermatology and Venereology, Siloam Hospital, Kupang, Indonesia; Province Health Office, East Nusa Tenggara, Kupang, Indonesia; Department of Dermatology and Venereology, Gadjah Mada University, Yogyakarta, Indonesia; Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, United Kingdom |
Siregar G.O., Sumba Foundation, Sumba, Indonesia; Harianja M., Sumba Foundation, Sumba, Indonesia; Adella J., Sumba Foundation, Sumba, Indonesia; Krismawati H., Center of Health System and Strategy, Ministry of Health, Jakarta, Indonesia; Sundari E.S., Department of Dermatology and Venereology, Siloam Hospital, Kupang, Indonesia; Ataupah M.R., Province Health Office, East Nusa Tenggara, Kupang, Indonesia; Laiskodat R.D., Province Health Office, East Nusa Tenggara, Kupang, Indonesia; Bøgh C., Sumba Foundation, Sumba, Indonesia; Soebono H., Department of Dermatology and Venereology, Gadjah Mada University, Yogyakarta, Indonesia; Grijsen M.L., Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, United Kingdom |
[No abstract available] |
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awareness; disease burden; disease transmission; health care personnel; human; leprosy; multibacillary leprosy; nerve injury; Note; paucibacillary leprosy; polypharmacy; primary health care; skin care; teledermatology; telemedicine |
Wellcome Trust, WT; Sumba Foundation |
Funding text 1: The project was financially supported by the Wellcome Trust Africa Asia Programme Vietnam. The authors declare that they have no conflicts of interest. ; Funding text 2: We extend our sincere gratitude to all Sumba Foundation healthcare workers. We wish to acknowledge Ben Naafs for sharing his expertise on leprosy with the clinical team. |
Elsevier Ltd |
27723682 |
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Note |
#N/A |
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30 |
Rahyussalim A.J.; Putra M.N.S.; Nasser M.K.; Kusuma B.W.; Kurniawati T.; Canintika A.F. |
Rahyussalim, Ahmad Jabir (57218212767); Putra, Muhammad Nadhil Sunaryo (59133578700); Nasser, Mochammad Kamal (57802348500); Kusuma, Bagus Wijaya (59132369000); Kurniawati, Tri (57212313637); Canintika, Anissa Feby (57208821931) |
57218212767; 59133578700; 57802348500; 59132369000; 57212313637; 57208821931 |
Cervical tuberculosis treated with closed system abscess evacuation, and percutaneous laser disc decompression combined with secretome derived from umbilical cord mesenchymal stem cells: A case report |
2024 |
International Journal of Surgery Case Reports |
119 |
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109764 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85193518532&doi=10.1016%2fj.ijscr.2024.109764&partnerID=40&md5=8029d9c943e64283db0533572f3d0121 |
Department of Orthopaedics and Traumatology, Cipto Mangunkusumo National General Hospital and Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Stem Cells and Tissue Engineering Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Rahyussalim A.J., Department of Orthopaedics and Traumatology, Cipto Mangunkusumo National General Hospital and Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia, Stem Cells and Tissue Engineering Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Putra M.N.S., Department of Orthopaedics and Traumatology, Cipto Mangunkusumo National General Hospital and Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Nasser M.K., Department of Orthopaedics and Traumatology, Cipto Mangunkusumo National General Hospital and Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Kusuma B.W., Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Kurniawati T., Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia, Stem Cells and Tissue Engineering Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Canintika A.F., Department of Orthopaedics and Traumatology, Cipto Mangunkusumo National General Hospital and Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Introduction and importance: Minimal invasive surgery is preferred as it offers the same benefit with less tissue damage, especially in the cervical area where a lot of critical structure resides. Mesenchymal stem cells (MSCs) and its secretome provide a promising regenerative intervention to damaged tissue. We report a cervical spinal tuberculosis case with hemiparesis treated with minimally invasive surgery combined with a regenerative approach. Case presentation: A 13-year-old boy presented with weakness in his left arm and left leg, accompanied by hemiparesthesia. The patient was unable to get up from bed, run, and jumpRadiology examination showed compression fracture, intervertebral disc retropulsion, spinal cord compression, and paravertebral cold abscess. The patient was treated with a single minimal invasive surgery consisting of closed system abscess evacuation, and percutaneous laser disc decompression combined with umbilical cord-derived mesenchymal stem cells. Clinical discussion: The pain, weakness, and numbness were gone two days after surgery. The patient could carry out normal activities, even doing sports such as mini soccer and badminton. This clinical improvement was obtained as he carried out some procedures. The cold abscess aspiration removed infection focus which prevents further vertebra destruction, PLDD which decompresses the retropulsed discs, and implantation of MSCs and secretomes which regenerate and strengthen the destructed bone and surrounding tissue. Conclusion: Closed system abscess evacuation, and percutaneous laser disc degeneration combined with secretome derived from UC-MSC are minimally-invasive strategies with promising results. Further studies are required to investigate its efficacy. © 2024 The Authors |
Hemiparesis; Paravertebral cold abscess; PLDD; Secretome; Tuberculosis spondylitis; Umbilical cord-derived MSCs (UC-MSCs) |
abscess; adolescent; Article; aspiration; case report; cervical spinal tuberculosis; cervical spine; clinical article; compression fracture; decompression; deformity; dermatome; echography; exercise; fine needle aspiration biopsy; general anesthesia; granuloma; histiocyte; hospital admission; hospital discharge; human; human tissue; implantation; intervertebral disk; kyphosis; lower limb; male; minimally invasive surgery; motor performance; muscle strength; nuclear magnetic resonance imaging; outpatient care; pain; paresthesia; percutaneous discectomy; posterior longitudinal ligament; prone position; rib; scapula; secretome; sitting; spinal cord compression; subluxation; tissue regeneration; tuberculosis; umbilical cord mesenchymal stem cell; upper limb; vertebra body; visual analog scale; |
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Elsevier Ltd |
22102612 |
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Article |
Q3 |
193 |
19555 |
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36 |
Moegni F.; Kouwagam A.D.; Hakim S.; Priyatini T.; Meutia A.P.; Santoso B.I. |
Moegni, Fernandi (55450456100); Kouwagam, Anggrainy Dwifitriana (57225978823); Hakim, Surahman (57192276095); Priyatini, Tyas (57192265423); Meutia, Alfa Putri (57203368133); Santoso, Budi Iman (57201498069) |
55450456100; 57225978823; 57192276095; 57192265423; 57203368133; 57201498069 |
Rectovaginal fistula as a complication of rectal injury during vaginal reconstructive surgery: A case report |
2024 |
International Journal of Surgery Case Reports |
120 |
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109856 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85196201861&doi=10.1016%2fj.ijscr.2024.109856&partnerID=40&md5=474e5b9f2894a7d3b432448304bb7256 |
Division of Urogynecology and Reconstruction, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo National General Hospital, Indonesia |
Moegni F., Division of Urogynecology and Reconstruction, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo National General Hospital, Indonesia; Kouwagam A.D., Division of Urogynecology and Reconstruction, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo National General Hospital, Indonesia; Hakim S., Division of Urogynecology and Reconstruction, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo National General Hospital, Indonesia; Priyatini T., Division of Urogynecology and Reconstruction, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo National General Hospital, Indonesia; Meutia A.P., Division of Urogynecology and Reconstruction, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo National General Hospital, Indonesia; Santoso B.I., Division of Urogynecology and Reconstruction, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo National General Hospital, Indonesia |
Introduction and importance: Rectovaginal fistula is a complication that may occur due to rectal injury during vaginal reconstructive surgery. To prevent these complications, the recognition of the injury is an important factor so that primary repair can be done. The primary repair can reduce the risk of complications such as fistula formation, and also reduce the physical and psychological impact on the patient. Case presentation: A 33-year-old woman, came with a chief complaint of fecal leakage from the vagina and abdominal pain three months before admission with a history of vaginal reconstructive surgery due to vaginal agenesis. Eleven years after the reconstruction, the patient was diagnosed with recurrent obstruction caused by vaginal synechia. During the surgery of synechia release, rectum injury occurred. Even though primary closure repair was done at that time, several months later there was a complication of rectovaginal fistule formation in the form of fecal leakage from the vagina. The corrective surgery is performed in collaboration with a surgical gastroenterologist. Clinical discussion: Iatrogenic rectal injury may occur during gynecological surgery. A fistula that occurs after the reconstruction of vaginal agenesis is a high-type rectovaginal fistula, making the repairs more complex. Collaboration surgery between surgical gastroenterologist and gynecologist may be an option in such cases. Conclusion: Rectovaginal fistula is a rare but serious complication of vaginal reconstructive surgery. Early recognition, immediate management, and postoperative follow-up are essential in cases of rectal injury during vaginal reconstructive surgery. © 2024 |
Rectovaginal fistula; Vaginal agenesis; Vaginal reconstructive surgery |
abdominal hysterectomy; abdominal pain; adhesiolysis; adult; amnion; Article; case report; cervicovaginal synechia; clinical article; clinical outcome; echography; feces incontinence; female; gastroenterologist; hematometra; hematosalpinx; hospital admission; human; iatrogenic disease; implantation; laparotomy; menstruation disorder; middle aged; ovarian cystectomy; rectovaginal fistula; rectum perforation; recurrent disease; salpingectomy; surgical approach; surgical injury; tissue adhesion; urogynecologist; uterine tube disease; vagina aplasia; vagina reconstruction; Wexner score |
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Elsevier Ltd |
22102612 |
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Article |
Q3 |
193 |
19555 |
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39 |
Dirjayanto V.J.; Martin-Ruiz C.; Pompei G.; Rubino F.; Kunadian V. |
Dirjayanto, Valerie Josephine (57404619000); Martin-Ruiz, Carmen (6701718262); Pompei, Graziella (57242359600); Rubino, Francesca (57208753088); Kunadian, Vijay (55390915800) |
57404619000; 6701718262; 57242359600; 57208753088; 55390915800 |
The association of inflammatory biomarkers and long-term clinical outcomes in older adults with non-ST elevation acute coronary syndrome |
2024 |
International Journal of Cardiology |
409 |
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132177 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85193480301&doi=10.1016%2fj.ijcard.2024.132177&partnerID=40&md5=8b9f741259fcdc823e950f8afd151a9c |
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, United Kingdom; Faculty of Medicine, Universitas Indonesia, Indonesia; BioScreening Core Facility, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom; Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, FE, Cona, Italy; Division of Cardiology, Department of Medicine, University of Verona, Verona, Italy; Cardiothoracic Centre, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom |
Dirjayanto V.J., Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, United Kingdom, Faculty of Medicine, Universitas Indonesia, Indonesia; Martin-Ruiz C., BioScreening Core Facility, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom; Pompei G., Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, United Kingdom, Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, FE, Cona, Italy; Rubino F., Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, United Kingdom, Division of Cardiology, Department of Medicine, University of Verona, Verona, Italy; Kunadian V., Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, United Kingdom, Cardiothoracic Centre, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom |
Background: The prognostic significance of inflammatory markers on the long-term risk of major adverse cardiovascular and cerebrovascular events (MACCE) in older NSTEACS patients remains unclear. Methods: NSTEACS patients aged 75 and older were recruited to the multicentre cohort study Improve Cardiovascular Outcomes in High-Risk PatieNts with Acute Coronary Syndrome (ICON1). Inflammatory markers including interleukin-6 (IL-6), myeloperoxidase (MPO), high-sensitivity C-reactive protein (hsCRP), fibrinogen and tumor necrosis factor-alpha (TNF-α) were collected at baseline. Primary outcome was MACCE consisting of all-cause mortality, reinfarction, stroke/transient ischaemic attack, urgent revascularization, and significant bleeding at 5-year follow-up. Results: There were 230 patients with baseline IL-6 (median age 80.9 [interquartile range (IQR):78.2–83.9] years). High IL-6 was not associated with MACCE, but it was independently associated with all-cause mortality (adjusted hazard ratio [aHR]: 2.26 [95% Confidence Interval (CI):1.34–3.82]; P = 0.002). For patients with hsCRP (n = 260, median age 80.9 [IQR:77.9–84.1] years), higher levels were significantly associated with increased risk of MACCE (aHR:1.77 [95% CI:1.26–2.49], P = 0.001). In the cohort with MPO (230 patients, median age 80.9 [IQR:78.2–83.9] years), lower MPO was independently associated with the risk of MACCE (aHR: 0.67 [95%CI:0.46–0.96]; P = 0.029). There was no prognostic significance with fibrinogen and TNF-α. Conclusion: Among older NSTEACS patients, elevated IL-6 and hsCRP were associated with increased risk of all-cause mortality and MACCE, respectively. Low MPO levels were associated with higher MACCE. Further studies are required to determine how these biomarkers should influence treatment strategy in this understudied subset. Clinical Trial Registration: NCT01933581 © 2024 Elsevier B.V. |
Inflammatory biomarkers; Major adverse cardiovascular events; Non-ST elevation acute coronary syndrome; Older adults |
Acute Coronary Syndrome; Aged; Aged, 80 and over; Biomarkers; C-Reactive Protein; Cohort Studies; Female; Follow-Up Studies; Humans; Inflammation; Interleukin-6; Male; Peroxidase; Prognosis; Time Factors; Treatment Outcome; biological marker; C reactive protein; fibrinogen; interleukin 6; myeloperoxidase; troponin; tumor necrosis factor; C reactive protein; interleukin 6; peroxidase; acute coronary syndrome; adult; all cause mortality; angiography; Article; atrial fibrillation; blood pressure; cardiogenic shock; cardiomyopathy; cardiovascular disease; cerebrovascular accident; chi square test; clinical outcome; confidence interval; coronary artery bypass graft; demographics; electrocardiography; enzyme linked immunosorbent assay; follow up; hazard ratio; heart arrhythmia; heart reinfarctio |
NIHR Newcastle Biomedical Research Centre; National Institute for Health and Care Research, NIHR; Newcastle cardiovascular research team; Newcastle University; Newcastle upon Tyne Hospitals NHS Foundation Trust; British Heart Foundation, BHF, (CS/15/7/31679); British Heart Foundation, BHF |
We are grateful to the Newcastle cardiovascular research team for their support with the long-term follow-up. This research is supported by the National Institute for Health Research (NIHR) Newcastle Biomedical Research Centre based at Newcastle-upon-Tyne Hospitals NHS Foundation Trust and Newcastle University. VK has received research funding from the British Heart Foundation (CS/15/7/31679). |
Elsevier Ireland Ltd |
01675273 |
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38761976 |
Article |
Q1 |
1122 |
3475 |
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43 |
Kurniawan R.; Taslim N.A.; Hardinsyah H.; Syauki A.Y.; Idris I.; Aman A.M.; Permatasari H.K.; Wiyarta E.; Surya R.; Mayulu N.; Putra P.P.; Tjandrawinata R.R.; Tallei T.E.; Kim B.; Tsopmo A.; Nurkolis F. |
Kurniawan, Rudy (57990353000); Taslim, Nurpudji Astuti (57194571794); Hardinsyah, Hardinsyah (56586054400); Syauki, Andi Yasmin (57376214300); Idris, Irfan (16636857800); Aman, Andi Makbul (57193706169); Permatasari, Happy Kurnia (57194728338); Wiyarta, Elvan (57221521342); Surya, Reggie (56610805600); Mayulu, Nelly (57303104200); Putra, Purnawan Pontana (57222390016); Tjandrawinata, Raymond Rubianto (6603266135); Tallei, Trina Ekawati (57193317686); Kim, Bonglee (51663469700); Tsopmo, Apollinai |
57990353000; 57194571794; 56586054400; 57376214300; 16636857800; 57193706169; 57194728338; 57221521342; 56610805600; 57303104200; 57222390016; 6603266135; 57193317686; 51663469700; 6602260089; 57226728465 |
Pharmacoinformatics and cellular studies of algal peptides as functional molecules to modulate type-2 diabetes markers |
2024 |
Future Foods |
9 |
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100354 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85191446983&doi=10.1016%2fj.fufo.2024.100354&partnerID=40&md5=7ba8790954696285f27694dbeba70fd5 |
Graduate from School of Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Diabetes Connection Care, Eka Hospital Bumi Serpong Damai, Tangerang, 15321, Indonesia; Division of Clinical Nutrition, Department of Nutrition, Faculty of Medicine, Hasanuddin University, Makassar, 90245, Indonesia; Division of Applied Nutrition, Faculty of Human Ecology, Department of Community Nutrition, IPB University, Bogor, Indonesia; Department of Physiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Makassar, Indonesia; Department of Biochemistry and Biomolecular, Faculty of Medicine, University of Brawijaya, Malang, 65145, Indonesia; Department of Neurology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Hospital, Jakarta, 10430, Indonesia; Department of Food Technology, Faculty of Engineering, Bina Nusantara University, Jakarta, 11480, Indonesia; Department of Nutrition, Faculty of Health Science, Muhammadiyah Manado University, Manado, 95249, Indonesia; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Andalas, Padang, 25163, Indonesia; Department of Biotechnology, Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta, 12930, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, 95115, Indonesia; Department of Pathology, College of Korean Medicine, Kyung Hee University, Kyungheedae-Ro 26, Dong-Daemun-Gu, Seoul, 05254, South Korea; Food Science and Nutrition Program, Department of Chemistry, Carleton University, 1125 Colonel by Drive, Ottawa, ON K1S 5B6, Canada; Department of Biological Sciences, Faculty of Sciences and Technology, State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga), Yogyakarta, 55281, Indonesia |
Kurniawan R., Graduate from School of Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia, Diabetes Connection Care, Eka Hospital Bumi Serpong Damai, Tangerang, 15321, Indonesia; Taslim N.A., Division of Clinical Nutrition, Department of Nutrition, Faculty of Medicine, Hasanuddin University, Makassar, 90245, Indonesia; Hardinsyah H., Division of Applied Nutrition, Faculty of Human Ecology, Department of Community Nutrition, IPB University, Bogor, Indonesia; Syauki A.Y., Division of Clinical Nutrition, Department of Nutrition, Faculty of Medicine, Hasanuddin University, Makassar, 90245, Indonesia; Idris I., Department of Physiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Aman A.M., Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Makassar, Indonesia; Permatasari H.K., Department of Biochemistry and Biomolecular, Faculty of Medicine, University of Brawijaya, Malang, 65145, Indonesia; Wiyarta E., Department of Neurology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Hospital, Jakarta, 10430, Indonesia; Surya R., Department of Food Technology, Faculty of Engineering, Bina Nusantara University, Jakarta, 11480, Indonesia; Mayulu N., Department of Nutrition, Faculty of Health Science, Muhammadiyah Manado University, Manado, 95249, Indonesia; Putra P.P., Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Andalas, Padang, 25163, Indonesia; Tjandrawinata R.R., Department of Biotechnology, Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta, 12930, Indonesia; Tallei T.E., Department of Biology, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, 95115, Indonesia; Kim B., Department of Pathology, College of Korean Medicine, Kyung Hee University, Kyungheedae-Ro 26, Dong-Daemun-Gu, Seoul, 05254, South Korea; Tsopmo A., Food Science and Nutrition Program, Department of Chemistry, Carleton University, 1125 Colonel by Drive, Ottawa, ON K1S 5B6, Canada; Nurkolis F., Department of Biological Sciences, Faculty of Sciences and Technology, State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga), Yogyakarta, 55281, Indonesia |
Novel dietary strategies are urgently needed to address the limitations of current management and treatment options of Type-2 Diabetes (T2D). Marine algae-derived peptides (MAP) represent a promising avenue, although, their potential remains mostly underexplored. This study employs pharmacoinformatics and in vitro methods to evaluate the antidiabetic properties of MAP and provide new insights their mechanisms to mitigate the prevalence of T2D. Through a systematic search and predictive modeling, peptides were identified and assessed for bioactivity, toxicity, and drug-likeness. Furthermore, molecular docking simulations with protein targets related to T2D identified binding sites that be used to optimize the activity of MAP. The structure-activity relationship profile of MAP reveals 13 candidates with probable activity (Pa) scores >0.4, indicative of insulin promoter. The peptide FDGIP (P13;Phe-Asp-Gly-Ile-Pro) from Caulerpa lentillifera had the best in silico assessment value compared to 50 other peptides and its activity was confirmed by in vitro data (e.g.EC50 60.4 and 57.9 for α-amylase and α-glucosidase inhibitions). Interestingly, in 3T3-L1 cells, P13 exhibited inhibitory activities against transcription factors and hormones (MAPK8-JNK1/PPARGC1A/Ghrelin/GLP-1/CPT-1) that can regulate blood sugar and decrease as anti-diabetes. P13 then appears to be a peptide with antidiabetic action that may be used in the formulation foods to manage T2D. © 2024 The Author(s) |
Algae; Diabetes; Functional food; MAPK8; Marine peptide; Metabolic syndrome |
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Elsevier B.V. |
26668335 |
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Article |
Q1 |
682 |
7352 |
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49 |
Gach M.W.; Lazarus G.; Simadibrata D.M.; Sinto R.; Saharman Y.R.; Limato R.; Nelwan E.J.; van Doorn H.R.; Karuniawati A.; Hamers R.L. |
Gach, Michael W. (57675752100); Lazarus, Gilbert (57214599425); Simadibrata, Daniel Martin (57202134322); Sinto, Robert (36099377100); Saharman, Yulia Rosa (55980934300); Limato, Ralalicia (57196224631); Nelwan, Erni J. (14527452900); van Doorn, H. Rogier (56941604800); Karuniawati, Anis (54886816200); Hamers, Raph L. (23034345900) |
57675752100; 57214599425; 57202134322; 36099377100; 55980934300; 57196224631; 14527452900; 56941604800; 54886816200; 23034345900 |
Antimicrobial resistance among common bacterial pathogens in Indonesia: a systematic review |
2024 |
The Lancet Regional Health - Southeast Asia |
26 |
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100414 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85192810137&doi=10.1016%2fj.lansea.2024.100414&partnerID=40&md5=8b7941694224b5ac273f8fd664e75b48 |
Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Department of Internal Medicine, Division of Tropical Medicine and Infectious Diseases, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Clinical Microbiology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Oxford University Clinical Research Unit, Hanoi, Viet Nam |
Gach M.W., Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Lazarus G., Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Simadibrata D.M., Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States; Sinto R., Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Department of Internal Medicine, Division of Tropical Medicine and Infectious Diseases, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Saharman Y.R., Department of Clinical Microbiology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Limato R., Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Nelwan E.J., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Internal Medicine, Division of Tropical Medicine and Infectious Diseases, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; van Doorn H.R., Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Oxford University Clinical Research Unit, Hanoi, Viet Nam; Karuniawati A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Clinical Microbiology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Hamers R.L., Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom |
Background: The WHO Global Antimicrobial Resistance Surveillance System (GLASS) aims to describe antimicrobial resistance (AMR) patterns and trends in common bacterial pathogens, but data remain limited in many low and middle-income countries including Indonesia. Methods: We systematically searched Embase, PubMed and Global Health Database and three Indonesian databases for original peer-reviewed articles in English and Indonesian, published between January 1, 2000 and May 25, 2023, that reported antimicrobial susceptibility for the 12 GLASS target pathogens from human samples. Pooled AMR prevalence estimates were calculated for relevant pathogen-antimicrobial combinations accounting for the sampling weights of the studies (PROSPERO: CRD42019155379). Findings: Of 2182 search hits, we included 102 papers, comprising 19,517 bacterial isolates from hospitals (13,647) and communities (5870). In hospital settings, 21.6% of Klebsiella pneumoniae isolates, 18.3% of Escherichia coli isolates, 35.8% of Pseudomonas aeruginosa isolates and 70.7% of Acinetobacter baumannii isolates were carbapenem-resistant; 29.9% of Streptococcus pneumoniae isolates were penicillin-resistant; and 22.2% of Staphylococcus aureus isolates were methicillin-resistant. Hospital prevalence of carbapenem-resistant K. pneumoniae and E. coli, and penicillin-resistant S. pneumoniae increased over time. In communities, 28.3% of K. pneumoniae isolates and 15.7% of E. coli isolates were carbapenem-resistant, 23.9% of S. pneumoniae isolates were penicillin-resistant, and 11.1% of S. aureus isolates were methicillin-resistant. Data were limited for the other pathogens. Interpretation: AMR prevalence estimates were high for critical gram-negative bacteria. However, data were insufficient to draw robust conclusions about the full contemporary AMR situation in Indonesia. Implementation of national AMR surveillance is a priority to address these gaps and inform context-specific interventions. Funding: Wellcome Africa Asia Programme Vietnam. © 2024 The Author(s) |
Antimicrobial resistance; Antimicrobial susceptibility; Bacteria; GLASS; Indonesia; Systematic review |
amikacin; cefepime; cefoxitin; ceftazidime; cephalosporin; colistin; cotrimoxazole; doripenem; extended spectrum beta lactamase; fosfomycin; gentamicin; imipenem; meropenem; nitrofurantoin; oxacillin; piperacillin plus tazobactam; quinoline derived antiinfective agent; tigecycline; tobramycin; Acinetobacter baumannii; antibacterial activity; antibiotic resistance; antibiotic sensitivity; Article; bacterial load; bacterium isolation; carbapenem resistance; community acquired infection; disk diffusion; epsilometer test; Escherichia coli; geographic distribution; Haemophilus influenzae; hospital infection; human; Indonesia; infection risk; Klebsiella pneumoniae; matrix assisted laser desorption ionization time of flight mass spectrometry; meta analysis; methicillin resistance; methicillin res |
Kementerian Pendidikan, Kebudayaan, Riset, dan Teknologi, MECRT; Oxford University Clinical Academic Graduate School, OUCAGS; OUCRU; JPT Family Trust; Ministry of Education, Culture, Research, and Technology Republic of Indonesia; Wellcome Africa Asia Programme Vietnam, (106680/Z/14/Z); Lembaga Pengelola Dana Pendidikan, LPDP, (202101182688); Lembaga Pengelola Dana Pendidikan, LPDP |
Funding text 1: Wellcome Africa Asia Programme Vietnam.None. Funding statement: This work was funded by the Wellcome Africa Asia Programme Vietnam (106680/Z/14/Z), which also supports RLH and HRVD. MG was supported by the JPT Family Trust award and Oxford University Clinical Academic Graduate School. RL was supported by an OUCRU Prize Studentship and a Nuffield Dept of Medicine Tropical Network Fu |
Elsevier Ltd |
27723682 |
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#N/A |
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54 |
Oesman I.; Kodrat E.; Canintika A.F.; Antono I.S.W.; Jaya I.K.; Adhimulia K.J. |
Oesman, Ihsan (57203961169); Kodrat, Evelina (57191430080); Canintika, Anissa Feby (57208821931); Antono, Ilham Suryo Wibowo (59000682200); Jaya, Indra Kusuma (59000451200); Adhimulia, Kevin Jonathan (57222107905) |
57203961169; 57191430080; 57208821931; 59000682200; 59000451200; 57222107905 |
Synovial lipomatosis of the ankle joint: A rare case report |
2024 |
International Journal of Surgery Case Reports |
119 |
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109694 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85191255858&doi=10.1016%2fj.ijscr.2024.109694&partnerID=40&md5=9b5c9b0697805e6cfe7e48c95867d671 |
Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Oesman I., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kodrat E., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Canintika A.F., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Antono I.S.W., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Jaya I.K., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Adhimulia K.J., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction and importance: Synovial lipomatosis is a rare disease that often results in joint discomfort, swelling, and effusion. Only a few reported cases have been documented so far. Case presentation: We reported a 50-year-old woman with synovial lipomatosis of the ankle joint. The patient presented with left ankle pain since the least two years, accompanied by swelling and redness. Physical examination demonstrated swollen ankle with warmth palpation. Magnetic resonance imaging (MRI) demonstrated hyperintensity of the ankle joint on the posterior and anterolateral side, thickening of the synovium, and bone marrow edema around the talar bone, surrounding the sinus tarsi. Histopathological examination demonstrated fatty tissues with nonspecific inflammation, suggesting synovial lipomatosis. We performed synovectomy, and the pain did not recur at 1 year of follow-up. Clinical discussion: Synovial lipomatosis is a highly uncommon benign condition. Histopathologically, synovial lipomatosis is characterized by notable adipocyte infiltration into the subsynovial tissue and a villous or frond-like morphology of the synovium. It also features transversely hyperplastic synovial lining cells. Conclusion: Synovial lipomatosis of the ankle joint is a rare entity. Further studies are required to investigate this disease and its management. © 2024 The Authors |
Ankle; Case report; Lipoma arborescens; Synovial lipomatosis |
adult; ankle joint; ankle pain; Article; bone marrow edema; case report; clinical article; female; follow up; histopathology; human; human tissue; lipomatosis; middle aged; nuclear magnetic resonance imaging; physical examination; synovectomy; synovium |
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Elsevier Ltd |
22102612 |
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Article |
Q3 |
193 |
19555 |
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55 |
Iqhrammullah M.; Yudhistira Refin R.; Fitria Andika F.; Amirah S.; Fahd Abdurrahman M.; Alina M.; Yufika A.; Abdullah A. |
Iqhrammullah, Muhammad (57208859701); Yudhistira Refin, Randa (59152653400); Fitria Andika, Fina (59134867400); Amirah, Shakira (57782995800); Fahd Abdurrahman, Muhammad (57929174600); Alina, Meulu (58690545900); Yufika, Amanda (57204690418); Abdullah, Asnawi (24478702900) |
57208859701; 59152653400; 59134867400; 57782995800; 57929174600; 58690545900; 57204690418; 24478702900 |
Dropout rate in clinical trials of smartphone apps for diabetes management: A meta-analysis |
2024 |
Diabetes Research and Clinical Practice |
212 |
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111723 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85194961781&doi=10.1016%2fj.diabres.2024.111723&partnerID=40&md5=6922ab6947fd9f8f7fad9c946a418bb5 |
Postgraduate Program of Public Health, Universitas Muhammadiyah Aceh, Banda Aceh, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Medical Research Unit, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia; Department of Family Medicine, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia; Physical Medicine and Rehabilitation Residency Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Public Health, Universitas Muhammadiyah Aceh, Banda Aceh, Indonesia |
Iqhrammullah M., Postgraduate Program of Public Health, Universitas Muhammadiyah Aceh, Banda Aceh, Indonesia; Yudhistira Refin R., Postgraduate Program of Public Health, Universitas Muhammadiyah Aceh, Banda Aceh, Indonesia; Fitria Andika F., Postgraduate Program of Public Health, Universitas Muhammadiyah Aceh, Banda Aceh, Indonesia; Amirah S., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Fahd Abdurrahman M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Alina M., Medical Research Unit, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia; Yufika A., Department of Family Medicine, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia, Physical Medicine and Rehabilitation Residency Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Abdullah A., Postgraduate Program of Public Health, Universitas Muhammadiyah Aceh, Banda Aceh, Indonesia, Faculty of Public Health, Universitas Muhammadiyah Aceh, Banda Aceh, Indonesia |
Applicability of smartphone-based digital health in diabetes management still face challenges due to low user retention or engagement. Thus, this systematic and meta-analysis aimed to estimate the dropout rate from the clinical trials. Search of literature was performed on 4 September 2023 through various databases (PubMed, Scilit, Scopus, Embase, and Web of Science). Those reporting clinical trials of smartphone apps for diabetic controls (either type 1 or type 2 diabetes mellitus) were screened and selected in accordance with PRISMA guideline. Of 5,429 identified records, as many as 36 studies were found eligible with a total of 3,327 patients in the intervention group. The overall dropout rate was 29.6 % (95 %CI: 25 %—34.3 %) with high heterogeneity (p-Het < 0.001; I2 = 84.84 %). Sample size, intervention duration, patients’ age and gender, and cultural adaptation on the app appeared to be non-significant moderators (p > 0.05). In sub-group levels, notably high dropout rates were observed in studies performing cultural adaptation (34.6 %) and conducted in high-income countries (31.9 %). Given the high dropout rate, the engagement level toward diabetic management apps in real-world setting is expected to be low. High heterogeneity in this study, however, requires careful interpretation of the foregoing results. PROSPERO: CRD42023460365 (14 September 2023). © 2024 Elsevier B.V. |
Clinical trial; Digital apps; Digital health; Engagement; Smartphone |
Clinical Trials as Topic; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Humans; Mobile Applications; Patient Dropouts; Smartphone; hemoglobin A1c; artificial intelligence; clinical trial (topic); diabetes mellitus; glucose blood level; high income country; human; insulin dependent diabetes mellitus; meta analysis; non insulin dependent diabetes mellitus; patient dropout; physical activity; quality control; randomized controlled trial (topic); Review; sample size; systematic review; diabetes mellitus; mobile application; smartphone; therapy |
Universitas Muhammadiyah Aceh, UNMUHA; Universitas Indonesia, UI; Universitas Syiah Kuala, USK |
Authors appreciate the collaboration between Universitas Muhammadiyah Aceh, Universitas Indonesia, and Universitas Syiah Kuala during the research and the making of this article. |
Elsevier Ireland Ltd |
01688227 |
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38830484 |
Review |
Q1 |
1634 |
1846 |
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57 |
Yusuf P.A.; Hubka P.; Konerding W.; Land R.; Tillein J.; Kral A. |
Yusuf, Prasandhya A. (57192156597); Hubka, Peter (6506008977); Konerding, Wiebke (37114569200); Land, Rüdiger (55496762300); Tillein, Jochen (6602884109); Kral, Andrej (55668482500) |
57192156597; 6506008977; 37114569200; 55496762300; 6602884109; 55668482500 |
Congenital deafness reduces alpha-gamma cross-frequency coupling in the auditory cortex |
2024 |
Hearing Research |
449 |
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109032 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85194041822&doi=10.1016%2fj.heares.2024.109032&partnerID=40&md5=6690a67c120d37697984b278b6b910f6 |
Hannover Medical School, Institute of AudioNeuroTechnology and Department of Experimental Otology of the ENT Clinics, Hannover, Germany; Faculty of Medicine University of Indonesia, Department of Medical Physiology and Biophysics / Medical Technology IMERI, Jakarta, Indonesia; J.W. Goethe University, Department of Otorhinolaryngology, Frankfurt am Main, Germany; Australian Hearing Hub, School of Medicine and Health Sciences, Macquarie University, Sydney, Australia |
Yusuf P.A., Hannover Medical School, Institute of AudioNeuroTechnology and Department of Experimental Otology of the ENT Clinics, Hannover, Germany, Faculty of Medicine University of Indonesia, Department of Medical Physiology and Biophysics / Medical Technology IMERI, Jakarta, Indonesia; Hubka P., Hannover Medical School, Institute of AudioNeuroTechnology and Department of Experimental Otology of the ENT Clinics, Hannover, Germany; Konerding W., Hannover Medical School, Institute of AudioNeuroTechnology and Department of Experimental Otology of the ENT Clinics, Hannover, Germany; Land R., Hannover Medical School, Institute of AudioNeuroTechnology and Department of Experimental Otology of the ENT Clinics, Hannover, Germany; Tillein J., J.W. Goethe University, Department of Otorhinolaryngology, Frankfurt am Main, Germany; Kral A., Hannover Medical School, Institute of AudioNeuroTechnology and Department of Experimental Otology of the ENT Clinics, Hannover, Germany, Australian Hearing Hub, School of Medicine and Health Sciences, Macquarie University, Sydney, Australia |
Neurons within a neuronal network can be grouped by bottom-up and top-down influences using synchrony in neuronal oscillations. This creates the representation of perceptual objects from sensory features. Oscillatory activity can be differentiated into stimulus-phase-locked (evoked) and non-phase-locked (induced). The former is mainly determined by sensory input, the latter by higher-level (cortical) processing. Effects of auditory deprivation on cortical oscillations have been studied in congenitally deaf cats (CDCs) using cochlear implant (CI) stimulation. CI-induced alpha, beta, and gamma activity were compromised in the auditory cortex of CDCs. Furthermore, top-down information flow between secondary and primary auditory areas in hearing cats, conveyed by induced alpha oscillations, was lost in CDCs. Here we used the matching pursuit algorithm to assess components of such oscillatory activity in local field potentials recorded in primary field A1. Additionally to the loss of induced alpha oscillations, we also found a loss of evoked theta activity in CDCs. The loss of theta and alpha activity in CDCs can be directly related to reduced high-frequency (gamma-band) activity due to cross-frequency coupling. Here we quantified such cross-frequency coupling in adult 1) hearing-experienced, acoustically stimulated cats (aHCs), 2) hearing-experienced cats following acute pharmacological deafening and subsequent CIs, thus in electrically stimulated cats (eHCs), and 3) electrically stimulated CDCs. We found significant cross-frequency coupling in all animal groups in > 70% of auditory-responsive sites. The predominant coupling in aHCs and eHCs was between theta/alpha phase and gamma power. In CDCs such coupling was lost and replaced by alpha oscillations coupling to delta/theta phase. Thus, alpha/theta oscillations synchronize high-frequency gamma activity only in hearing-experienced cats. The absence of induced alpha and theta oscillations contributes to the loss of induced gamma power in CDCs, thereby signifying impaired local network activity. © 2024 The Authors |
Alpha band; Cochlear implant; Connectivity; Development; Hearing loss; Theta band |
Acoustic Stimulation; Algorithms; Alpha Rhythm; Animals; Auditory Cortex; Auditory Pathways; Cats; Cochlear Implants; Deafness; Disease Models, Animal; Evoked Potentials, Auditory; Gamma Rhythm; Theta Rhythm; adult; alpha rhythm; animal experiment; Article; auditory cortex; auditory stimulation; beta rhythm; congenital deafness; controlled study; gamma rhythm; local field potential; low frequency oscillation; nerve cell network; nonhuman; primary auditory cortex; reproducibility; theta rhythm; vibration; algorithm; alpha rhythm; animal; auditory evoked potential; auditory nervous system; auditory stimulation; cat; cochlea prosthesis; congenital disorder; disease model; hearing impairment; pathophysiology |
Universitas Indonesia, UI; Deutsche Forschungsgemeinschaft, DFG, (DFG Kr 3370); Deutsche Forschungsgemeinschaft, DFG; Deutscher Akademischer Austauschdienst, DAAD, (PUTI Q2 2020, NKB-1515/UN2.RST/HKP.05.00/2020); Deutscher Akademischer Austauschdienst, DAAD |
Deutsche Forschungsgemeinschaft ( DFG Kr 3370 and Exc 2177 ); MedEl Comp, Innsbruck, Austria (to J.T.); DAAD \u2013 Indonesian German Scholarship Programme (IGSP) ; PUTI Q2 2020 (NKB-1515/UN2.RST/HKP.05.00/2020) Universitas Indonesia Publication Grant (to PAY). |
Elsevier B.V. |
03785955 |
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38797035 |
Article |
Q1 |
959 |
4505 |
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