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Widaty S., Sutarjo A.S., Wahid M.H., Darmawan I., Sitohang I.B.S. |
57208261546;57221634021;57192887722;57395174200;56734569200; |
The association between Malassezia spp. And pruritus in facial acne vulgaris |
2021 |
Journal of Pakistan Association of Dermatologists |
31 |
3 |
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391 |
397 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122215594&partnerID=40&md5=d681f660e92c0b469e87702a23617193 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Dermatology and Venereology, Dharmais Cancer Hospital-National Cancer Center, Jakarta, Indonesia; Department of Clinical Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Widaty, S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sutarjo, A.S., Department of Dermatology and Venereology, Dharmais Cancer Hospital-National Cancer Center, Jakarta, Indonesia; Wahid, M.H., Department of Clinical Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Darmawan, I., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sitohang, I.B.S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Background Acne vulgaris (AV) is a chronic inflammatory condition involving the pilosebaceous unit. Recent studies have shown that itching of mild-to-moderate severity is relatively common in patients with acne. Malassezia spp. is normal flora of skin surface, and can be found in acne lesions. Aim: To clarify the relationship between Malassezia spp. in facial acne lesions and their association with pruritus symptom. Methods This is a cross-sectional study conducted at dermatology and venereology outpatient clinic in a tertiary hospital in Indonesia. We recruited subjects with at least four inflammatory and four noninflammatory facial acne lesions. Acne was graded using Lehmann's criteria, and pruritus was graded using visual analog scale (VAS). Follicular content of acne lesions was collected for microscopic examination and fungal culture. Results Of the 120 subjects, 46 (38.3%) reported experiencing itching in acne lesions. Pruritus was more common in patients with mild AV. Among those with pruritus, fungal spore was found in 60.6% subjects. There was no statistically significant difference in terms of the presence and severity of pruritus and presence of Malassezia spp. determined by culture (p=0.332; 0.317). Conclusion Pruritus may accompany facial acne lesions. In this study, the presence and severity of pruritus did not correlate with the presence of Malassezia spp. in facial acne lesions. © 2021 Pakistan Association of Dermatologists. All rights reserved. |
Acne vulgaris; Fungal spores; Malassezia; Pruritus; Skin disease |
anti acne agent; acne vulgaris; adolescent; adult; Article; controlled study; cross-sectional study; disease association; disease severity; female; fungus culture; fungus spore; human; human tissue; Indonesia; major clinical study; Malassezia; male; microscopy; nonhuman; outpatient department; skin pruritus; tertiary care center; visual analog scale |
Pakistan Association of Dermatologists |
15609014 |
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Article |
Q4 |
129 |
25503 |
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2 |
Sudibio S., Anton J., Handoko H., Permata T.B.M., Kodrat H., Nuryadi E., Sofyan H.R., Mulyadi R., Aman R.A., Gondhowiardjo S. |
57283461500;57328462500;57204105168;57197808751;57210639849;57197806814;57328366500;56403164500;36848942500;6508327402; |
Outcome analysis and prognostic factors in patients of glioblastoma multiforme: An indonesian single institution experience |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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1410 |
1416 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119154241&doi=10.3889%2foamjms.2021.7502&partnerID=40&md5=9312ddc4112180679fb892c1d7cc2e79 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Neurology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Neurosurgery, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Sudibio, S., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Anton, J., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Handoko, H., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Permata, T.B.M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Kodrat, H., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Nuryadi, E., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Sofyan, H.R., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Neurology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Mulyadi, R., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Aman, R.A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Neurosurgery, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Gondhowiardjo, S., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
AIM: This study was done to assess the survival of patients with glioblastoma multiforme (GBM) and to identify factors that can affect patient survival. MATERIALS AND METHODS: From January 2015 to December 2019, 55 patients with histopathologically confirmed GBM and received adjuvant radiation/chemoradiation in our department were retrospectively analyzed. RESULTS: The median overall survival (OS) for entire cohort was 13 months and 1-year OS and 2-year OS rate were 52.7% and 3.6% with the mean follow-up period was 12 months. In univariate analysis, age (≤50 years vs. >50 years, p = 0.02), performance status (≥90 vs. 70–80 vs. <70, p < 0.001), radiation therapy oncology group recursive partitioning analysis (RTOG-RPA) classification (Class III vs. Class IV vs. Class V-VI, p < 0.001), parietal lobes tumor site (vs. others, p = 0.02), residual tumor volume (≤20.4 cm3 vs. >20.4 cm3, p = 0.001), and time to initiate adjuvant therapy (<4 weeks vs. 4-6 weeks vs. >6 weeks, p = 0.01) were significantly affect OS. In multivariate analysis, RTOG-RPA classification and involvement of parietal lobes were independent prognostic factors for OS. CONCLUSIONS: RTOG-RPA classification that consisted of age and performance status is an independent prognostic factor for the clinical outcome of GBM. Besides this well-known factor, we also identified the involvement of parietal lobe gives a strong negative influence on survival of GBM patients. © 2021 Sudibio Sudibio, Jellyca Anton, Handoko Handoko, Tiara Bunga Mayang Permata, Henry Kodrat, Endang Nuryadi, Henry Riyanto Sofyan, Rahmad Mulyadi, Renindra Ananda Aman, Soehartati Gondhowiardjo. |
Glioblastoma multiforme; Prognostic factors; Radiotherapy; Survival |
methylated DNA protein cysteine methyltransferase; adjuvant chemotherapy; adult; Article; basal ganglion; cancer prognosis; cancer radiotherapy; cancer size; cancer surgery; cancer survival; chemoradiotherapy; clinical outcome; cohort analysis; controlled study; corpus callosum; female; follow up; frontal lobe; glioblastoma; histopathology; human; human tissue; major clinical study; male; outcome assessment; overall survival; parietal lobe; prospective study; radiation dose; recursive partitioning; retrospective study; temporal lobe; tumor volume |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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3 |
Taufiqa Z., Chandra D.N., Helmizar H., Lipoeto N.I., Hegar B. |
57295694500;57190861000;57193098406;6507795270;6506273944; |
Micronutrient content and total lactic acid bacteria of dadiah pudding as food supplementation for pregnant women |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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1149 |
1155 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117031213&doi=10.3889%2foamjms.2021.6791&partnerID=40&md5=41ee51317717c3162ced81a45aa47265 |
Department of Nutrition, Doctoral Program, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Medical Education Unit, Faculty of Medicine, Universitas Andalas, Padang, 25144, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Department of Nutrition, Faculty of Public Health, Universitas Andalas, Padang, 25144, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Andalas, Padang, 25144, Indonesia; Department of Pediatrics, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia |
Taufiqa, Z., Department of Nutrition, Doctoral Program, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Medical Education Unit, Faculty of Medicine, Universitas Andalas, Padang, 25144, Indonesia; Chandra, D.N., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Helmizar, H., Department of Nutrition, Faculty of Public Health, Universitas Andalas, Padang, 25144, Indonesia; Lipoeto, N.I., Department of Nutrition, Faculty of Medicine, Universitas Andalas, Padang, 25144, Indonesia; Hegar, B., Department of Pediatrics, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia |
BACKGROUND: Dadiah, traditional yogurt from Indonesia, which is known as a source of probiotics, also contains micronutrients. AIM: This descriptive study aimed to determine whether additional ingredients and processes during the manufacture of Dadiah pudding maintain the iron, zinc, calcium, and total lactic acid bacteria (LAB) contents. METHODS: Dadiah pudding was made using Dadiah originated from Bukittinggi, West Sumatra. Micronutrient levels were analyzed according to Indonesian National Standard 01-2896-1998. The total LAB were counted by inoculating samples on Man, Rogosa, and Sharpe agar with serial dilution, and morphological identification was carried out using gram stain. RESULTS: In 100 g of original Dadiah, mango and chocolate Dadiah pudding contained 347.98, 276.61, and 279.29 mg of calcium; 4.87, 3.75, and 6.31 mg of zinc; 6.53, 6.60, and 9.39 mg of iron; and 6.4 × 10⁹, 6.1 × 10⁹, and 2.4 × 10⁹ CFU/ml LAB, respectively. CONCLUSION: This study found that modifying the original Dadiah into Dadiah pudding has been proved to affect the concentration of calcium, zinc, and iron and to maintain total LAB. We suggest that consuming Dadiah pudding may be a good choice as a food supplementation for pregnant women to optimize the golden period outcomes. © 2021 Zuhrah Taufiqa, Dian Novita Chandra, Helmizar Helmizar, Nur Indrawaty Lipoeto, Badriul Hegar. |
Dadiah pudding; Lactic acid bacteria; Micronutrients; Pregnant women; Probiotic |
calcium; iron; probiotic agent; trace element; yoghurt; zinc; adult; Article; bacterial count; colony forming unit; controlled study; dietary supplement; double blind procedure; female; fermentation; fermented product; food frequency questionnaire; food industry; gestational age; Gram staining; health center; human; human experiment; Indonesia; informed consent; lactic acid bacterium; microbial morphology; micronutrient intake; middle aged; normal human; pregnancy outcome; pregnant woman; randomized controlled trial; young adult |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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4 |
Rinaldi I., Putri A., Louisa M., Koesnoe S. |
23475122400;57214826648;41461551400;26028015000; |
High stat5a expression is associated with major molecular response achievement failure of chronic phase chronic myeloid leukemia patients receiving hydroxyurea before imatinib: A cross-sectional study |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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1160 |
1167 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117030211&doi=10.3889%2foamjms.2021.6911&partnerID=40&md5=f2aaf46fdf0c34ecbeb60cc8e6d66cac |
Department of Internal Medicine, Division of Hematology and Medical Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Rinaldi, I., Department of Internal Medicine, Division of Hematology and Medical Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Putri, A., Department of Internal Medicine, Division of Hematology and Medical Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Koesnoe, S., Department of Internal Medicine, Division of Allergy and Clinical Immunology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
BACKGROUND: STAT5 is a transcriptional factor which when highly expressed in chronic myeloid leukemia (CML) cells stimulate proliferation and mediate resistance from tyrosine kinase inhibitors, resulting in major molecular response (MMR) failure. STAT5 has two isoforms, STAT5A and STAT5B. However, prolonged use of imatinib appears to only upregulate STAT5A pathway. In addition, the resistance conferred by STAT5A does not extend to other drugs such as hydroxyurea. Hence, STAT5A and STAT5B might have different functions in CML cells. AIM: The objective of the study was to determine the association of STAT5A and STAT5B expression with MMR failure in CML patients. METHODS: This was a cross-sectional study of CML patients in chronic phase with age ≥ 18 years old, receiving IM therapy ≥ 12 months, and previously given hydroxyurea. MMR status was evaluated and patients were categorized as achieved or failed to achieve MMR. Expression levels of STAT5A and STAT5B were conducted using RT-PCR methods. Associations between STAT5A expression, STAT5B expression, hydroxyurea duration, and imatinib duration with MMR achievement were calculated using logistic regression. RESULTS: A total of 118 patients were analyzed; 71.1% failed to achieve MMR. Multivariate logistic regression analysis showed statistically significant association between high STAT5A expression (odds ratio [OR]: 3.852; 95% confidence interval [CI]: 1.420–10.452; p = 0.008), STAT5A/STAT5B interaction (OR: 0.150; 95% CI: 0.038–0.593; p = 0.007), longer hydroxyurea administration (OR: 3.882; 95% CI: 1.023–14.733; p = 0.046), and shorter imatinib administration (OR: 0.333; 95% CI: 0.132–0.840; p = 0.020) with MMR achievement failure. After adjusting STAT5A expression with STAT5A/STAT5B interaction, high STAT5A expression independently increased the likelihood of MMR achievement failure only in high expression STAT5B patients (OR: 3.852; 95% CI: 1.420–10.452; p = 0.008). CONCLUSION: High STAT5A expression which is induced by high STAT5B is associated with MMR achievement failure of chronic phase CML patients who received hydroxyurea before imatinib. Longer duration of hydroxyurea and shorter duration of IM confound of STAT5A expression to MMR achievement failure. © 2021 Ikhwan Rinaldi, Anastasia Putri, Melva Louisa, Sukamto Koesnoe. |
Breakpoint cluster region-ABL; Chronic myeloid leukemia; Imatinib; STAT5A; STAT5B |
eltrombopag; hemoglobin; hydroxyurea; imatinib; STAT5 protein; adult; age; Article; basophil; blood sampling; chronic myeloid leukemia; cross-sectional study; female; gene amplification; housekeeping gene; human; human cell; human experiment; leukocyte; lymphocyte; major clinical study; male; middle aged; neutrophil; overall survival; platelet count; protein expression; real time polymerase chain reaction; sex; thrombocyte |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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8 |
Sartika D., Nurrachmah E., Sukirman D.I., Mansyur M., Supartono B. |
57467276300;57466703100;57467568600;37085506800;57205286040; |
Ergonomic Risk-prone Activities toward Nurses in the Intensive Care and Emergency Room |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
T5 |
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48 |
53 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125269929&doi=10.3889%2fOAMJMS.2021.7851&partnerID=40&md5=e4f606505a7f1d2f7fa6498e532fb934 |
Health Polytechnic of Riau, Pekanbaru, Indonesia; Department of Medical Surgery, Faculty of Nursing, University of Indonesia, Jakarta, Indonesia; Department of Basic Science and Fundamentals of Nursing, Faculty of Nursing, University of Indonesia, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Faculty of Medicine, Pembangunan Nasional University, Jakarta, Indonesia |
Sartika, D., Health Polytechnic of Riau, Pekanbaru, Indonesia; Nurrachmah, E., Department of Medical Surgery, Faculty of Nursing, University of Indonesia, Jakarta, Indonesia; Sukirman, D.I., Department of Basic Science and Fundamentals of Nursing, Faculty of Nursing, University of Indonesia, Jakarta, Indonesia; Mansyur, M., Department of Community Medicine, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Supartono, B., Faculty of Medicine, Pembangunan Nasional University, Jakarta, Indonesia |
BACKGROUND: Nurses have the risk of ergonomic hazards in providing nursing care, especially with increasingly dynamic health services such as during Coronavirus disease-19 pandemic like today. AIM: The aim of the study was to evaluate activities prone to produce ergonomic risks during the implementation of nursing care in intensive care and emergency room (ER) of a hospital in Riau, Indonesia. METHODOLOGY: This study was conducted by observing the routine activities conducted by the nurses and using similar task group techniques equipped with Rapid Entire Body Assessment instrument. Those observed activities were obtained from 17 intensive care room nurses and ten ER nurses. There were six activities observed in the intensive care room: Bathing, transferring the patient, wounds dressing, taking blood samples for the AGDA examinations, as well as inserting the intravenous needle and electrocardiograms. Meanwhile, there were two activities observed in the ER: Transferring the patient and inserting the intravenous needle. RESULTS: The highest ergonomic risks activity in the intensive care room was bathing the patient with a total score of 13. At the ER, the highest risk score was transferring the patient with a total score of 12. Both activities were at level 4, indicating a high-risk condition. Thus, examinations and changes should be immediately initiated. CONCLUSION: The results are significant to be paid attention by the related parties at the hospital to facilitate some improvements immediately. In addition, the ergonomic approaches that can be suggested to the nurses are regular stretching, physical exercises, and applying ergonomic principles while working. © 2021 Dewi Sartika, Elly Nurrachmah, Dewi Irawaty Sukirman, Muchtaruddin Mansyur, Basuki Supartono. |
Emergency room; Ergonomic risk; Intensive care; Nurse’s activity; Nursing intervention |
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Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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12 |
Ramlan A.A.W., Mahri I., Firdaus R., Sugiarto A. |
57195941841;57459772200;57188923555;57189612291; |
Comparison of Efficacy of Premedication between Dexmedetomidine and Midazolam Intranasal for the Prevention of Emergence Delirium in Children Undergoing Ophthalmic Surgery |
2021 |
Turkish Journal of Anaesthesiology and Reanimation |
49 |
6 |
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439 |
444 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85124935387&doi=10.5152%2fTJAR.2021.1305&partnerID=40&md5=bd1c40a8ff29473a6db3aa32aacb92ad |
Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Ramlan, A.A.W., Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mahri, I., Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Firdaus, R., Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sugiarto, A., Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Objective: Emergence delirium (ED) is a condition that can occur when a child recovers from anaesthesia uncomfortably. ED can potentially injure children and indirectly discomforts parents. Various interventions were carried out to reduce ED, but there is no specific standard that has been established to prevent ED. Dexmedetomidine and midazolam are said to be effective in reducing ED. This study aims to determine the effectiveness of intranasal dexmedetomidine premedication compared to intranasal midazolam to prevent ED in children undergoing eye surgery. Methods: This study was a double-blinded randomised clinical trial. Paediatric patients aged 1-12 years with physical status ASA 1 and 2 who underwent eye surgery under general anaesthesia using sevoflurane inhalation were included in the study. There were 64 children obtained by consecutive sampling who underwent eye surgery in our institution between February and May 2019. The subjects were then randomised into the dexmedetomidine group and the midazolam group. Effectiveness was assessed from ED events, recovery time and post-premedication desaturation events. Data analysis was performed using Chi-square test and Mann–Whitney test. Results: ED incidence in the dexmedetomidine group was 11.18% compared to 28.12% in the midazolam group (P = .109). The recovery time was found to be at a median of 6 minutes for both groups, and no desaturation was found in either group. Conclusion: There is statistically no significant difference between the effectiveness of intranasal dexmedetomidine and midazolam premedication 30 minutes before induction to prevent ED occurrence in children undergoing eye surgery. © 2021 by Turkish Society of Anaesthesiology and Reanimation. |
Delirium; Dexmedetomidine; Emergence; Eye surgery; Midazolam |
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AVES |
2667677X |
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Article |
Q3 |
322 |
14155 |
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13 |
Sumapraja K., Hestiantoro A., Liem I.K., Boediono A., Jacoeb T.Z. |
55819683500;8743255100;55802927800;9040094200;57192887569; |
Effect of conditioned medium of umbilical cord-derived mesenchymal stem cells as a culture medium for human granulosa cells: An experimental study |
2021 |
International Journal of Reproductive BioMedicine |
19 |
12 |
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1037 |
1044 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85124898321&doi=10.18502%2fijrm.v19i12.10054&partnerID=40&md5=aa14230b44e7cc7c0f12adca3c46c2b5 |
Division of Reproductive Immunoendocrinology, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Cluster of Human Reproduction, Fertility and Family Planning, the Indonesian Medical Education and Research Institute Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Veterinary Medicine, Bogor Agricultural University, Bogor, Indonesia |
Sumapraja, K., Division of Reproductive Immunoendocrinology, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hestiantoro, A., Cluster of Human Reproduction, Fertility and Family Planning, the Indonesian Medical Education and Research Institute Universitas Indonesia, Jakarta, Indonesia; Liem, I.K., Department of Anatomy, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Boediono, A., Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Jacoeb, T.Z., Faculty of Veterinary Medicine, Bogor Agricultural University, Bogor, Indonesia |
Background: The umbilical cord-derived mesenchymal stem cells conditioned medium (UC-MSCs-CM) produces secretomes with anti-apoptotic properties, and has the potential to prevent apoptosis of granulosa cells (GC) during controlled ovarian hyperstimulation. Objective: To observe the effect of UC-MSCs-CM on the interaction between pro-and anti-apoptotic proteins and the influence of growth differentiation factor 9 (GDF9) production in GC. Materials and Methods: UC-MSCs-CM was collected from umbilical cord stem cell culture on passage 4. GC from 23 women who underwent in vitro fertilization were cultured and exposed to UC-MSCs-CM for 24 hr. Then RNA of the GC was extracted and the mRNA expression of BCL-2 associated X (BAX), survivin and GDF9 were analysed using quantitative real-time PCR. The spent culture media of the GC were collected for measurement of insulin growth factor 1 using ELISA. Results: The expression of BAX was significantly different after UC-MSCs-CM exposure (4.09E-7 vs. 3.74E-7, p = 0.02). No significant changes occurred in survivin, BAX/survivin ratio, and GDF9 expression after UC-MSCs-CM exposure (p > 0.05). The IGF-1 level of the CM was significantly higher after the CM was used as a culture medium for GC (2.28 vs. 3.07 ± 1.72, p ≤ 0.001). A significant positive correlation was found between survivin and GDF9 (r = 0.966, p ≤ 0.001). Conclusion: IGF-1 produced by UC-MSCs-CM can work in paracrine fashion through the IGF receptor, which can inhibit BAX and maintain GDF9 production. Moreover, under the influence of UC-MSCs-CM, GC are also capable of producing IGF-1, which can impact GC through autocrine processes. © Sumapraja et al. |
BAX; Conditioned medium; GDF9; IGF-1; Survivin |
anti apoptotic protein; baculoviral IAP repeat containing protein 5; complementary DNA; growth differentiation factor 9; Muellerian inhibiting factor; pro apoptotic protein; protein; protein Bax; protein bcl 2; recombinant follitropin; somatomedin; unclassified drug; adult; anesthesia; antiapoptotic activity; antral follicle count; Article; autocrine signaling; cell culture; clinical article; DNA synthesis; enzyme linked immunosorbent assay; female; granulosa cell; human; human cell; in vitro fertilization; information processing; mRNA expression level; oocyte; ovary follicle fluid; real time polymerase chain reaction; RNA extraction; umbilical cord mesenchymal stem cell |
Research and Clinical Center for Infertitlity |
24764108 |
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Article |
Q3 |
445 |
11118 |
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14 |
Kalaij A.G.I., Dirjayanto V.J., Yusuf S.M., Nelwan E.J. |
57223906853;57404619000;57359274400;14527452900; |
Immunogenicity and safety of adenovirus-based vector vaccines for COVID-19: a systematic review and meta-analysis |
2021 |
Medical Journal of Indonesia |
30 |
4 |
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264 |
278 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123701532&doi=10.13181%2fmji.oa.215559&partnerID=40&md5=480b6760fb0761aee17ad344ee18a3ce |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Infectious Disease and Immunology Research Center, Indonesia Medical and Education Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Kalaij, A.G.I., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Dirjayanto, V.J., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yusuf, S.M., Infectious Disease and Immunology Research Center, Indonesia Medical and Education Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Nelwan, E.J., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND Despite various research on vaccine development, severe acute respiratory syndrome coronavirus 2 infection continues to spread. Thus, developing a more effective vaccine for production and clinical efficacy is still in high demand. This review aimed to assess the immunogenicity and safety of adenovirus-based vector vaccines (Ad-vaccines) including Ad5-vectored, ChAdOx1 nCoV-19, rAd26-S or rAd5-S, and Ad26.COV2.S as the promising solutions for COVID-19. METHODS We conducted a systematic review and meta-analysis of clinical trials based on the preferred reporting items for systematic reviews and meta-analyses guidelines through PubMed, Scopus, Cochrane, and EBSCOhost until August 17, 2021. We implemented inclusion and exclusion criteria and assessed the studies using the US National Toxicology Program’s Office of Health Assessment and Translation risk of bias rating tool for human and animal studies. Pooled estimates of odds ratio (OR) were analyzed using fixed-effect model. RESULTS This systematic review yielded 12 clinical studies with a total of 75,105 subjects. Although the studies were heterogeneous, this meta-analysis showed that Ad-vaccine significantly increased protection and immune response against COVID-19 with a pooled efficacy of 84.68% compared to placebo (p<0.00001). Forest plot also indicated that Ad-vaccine conferred protection against moderate to severe COVID-19 with a pooled OR of 0.26 (p<0.00001). Ad-vaccine had also shown a good safety profile with local site pain and fever as the most common side effects. CONCLUSIONS Ad-vaccine had shown a good immunogenicity for COVID-19 with a good pooled efficacy and was proven safe for COVID-19 patients. © 2021 Authors. |
Adenovirus vaccine; COVID-19; Immunogenicity; Safety; SARS-CoV-2 |
adenovirus vaccine; vector vaccine; Article; comparative effectiveness; coronavirus disease 2019; drug delivery system; drug efficacy; drug safety; genetic reassortment; human; immune response; immunogenicity; meta analysis; outcome assessment; practice guideline; risk assessment; sensitivity analysis; seroconversion; systematic review; vaccination |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Article |
Q4 |
164 |
21905 |
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15 |
Lukman P.R., Saputra A., Elvira S.D., Heriani, Almasyhur A.F., Putri L.A., Alfonso C.A., Noviasari R.R. |
55981460300;57431501600;57192888533;57431901600;57203618023;57432304200;7004331573;57431697600; |
Efficacy of video-based psychotherapy in reducing psychological distress COVID-19 patients treated in isolation ward |
2021 |
Medical Journal of Indonesia |
30 |
4 |
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250 |
255 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123688789&doi=10.13181%2fmji.oa.215473&partnerID=40&md5=05a78950b452a144715a92b0e790ed60 |
Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Psychiatry, Columbia University Irving Medical Center, New York, United States; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Lukman, P.R., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Saputra, A., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Elvira, S.D., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Heriani, Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Almasyhur, A.F., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Putri, L.A., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Alfonso, C.A., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Psychiatry, Columbia University Irving Medical Center, New York, United States; Noviasari, R.R., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND Hospitalized patients with COVID-19 experience isolation during treatment, which may cause psychological distress. Thus, alternative ways to deliver psychological support are needed when face-to-face therapy is not possible. This study aimed to investigate the efficacy of video-based psychotherapy in reducing distress in COVID-19 patients treated in an isolation ward. METHODS This quasi-experimental trial without a control group included 42 COVID-19 patients aged 20–59 years. Participants were recruited conveniently in the COVID-19 isolation ward in Cipto Mangunkusumo Hospital, Jakarta, Indonesia. They watched three brief psychotherapy videos including relaxation, managing thoughts and emotions, and mindfulness for approximately 30 min. The videos were created by the Department of Psychiatry, Faculty of Medicine, Universitas Indonesia. Subjective units of distress scale (SUDS) was measured before and after watching all videos. Data were analyzed using the Wilcoxon-signed rank test. RESULTS All 42 subjects finished watching the videos. 31 subjects experienced a significant median decrease in SUDS score after the intervention. The effect size of the psychotherapy videos for the SUDS score was 0.485 (95% CI 0.302 to 0.634). CONCLUSIONS Watching psychotherapy videos is effective in reducing the SUDS score for COVID-19 patients in an isolation ward. Our brief video-based psychotherapy intervention has reduced psychological distress in hospitalized COVID-19 patients with limited access to face-to-face consultations due to the risk of disease transmission. © 2021 Authors. |
COVID-19; Instructional film and audio; Patient isolation; Psychological distress; Psychotherapy |
adult; Article; clinical article; coronavirus disease 2019; distress syndrome; emotion; female; human; length of stay; male; middle aged; mindfulness; psychotherapy; quasi experimental study; questionnaire; relaxation sensation; subjective unit of distress scale; video based psychotherapy |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Article |
Q4 |
164 |
21905 |
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16 |
Hidayati E.R.N., Suharti A., Suratinoyo A.T., Zahra S.R., Nusdwinuringtyas N. |
57192909138;57430912200;57430912300;57431910100;56608215500; |
Feasibility of the modified 30-second sit-to-stand test in an isolation ward omoderate COVID-19 |
2021 |
Medical Journal of Indonesia |
30 |
4 |
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306 |
310 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123687687&doi=10.13181%2fmji.bc.215477&partnerID=40&md5=46eb378aa55f3d5a5501b012c001442f |
Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Universitas Indonesia, Universitas Indonesia Hospital, Depok, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Hidayati, E.R.N., Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Universitas Indonesia, Universitas Indonesia Hospital, Depok, Indonesia; Suharti, A., Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Universitas Indonesia, Universitas Indonesia Hospital, Depok, Indonesia; Suratinoyo, A.T., Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Universitas Indonesia, Universitas Indonesia Hospital, Depok, Indonesia; Zahra, S.R., Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Universitas Indonesia, Universitas Indonesia Hospital, Depok, Indonesia; Nusdwinuringtyas, N., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND The recovery after prolonged immobilization during hospitalization because of COVID-19 is the primary goal of moderate to severe COVID-19 rehabilitation. Lower extremity muscle function assessment after immobilization is needed before starting mobilization. Hence, this study aimed to evaluate the feasibility of the modified 30-second sit-to-stand test (m30STS) as one of the prospective tools of functional capacity assessment in moderate COVID-19. METHODS This cross-sectional study recruited the subjects consecutively. All eligible subjects with oxygen saturation (SaO2 ) ≥95% with or without oxygen supplementation performed the m30STS following the Bohannon’s guidelines. The score of m30STS was calculated based on the number of stands completed within 30 sec. A higher score of the m30STS indicated better lower extremity function. RESULTS Mean score of m30STS was 13.3. No subjects had oxygen desaturation or increased heart rate, and no fall incidents occurred. CONCLUSIONS The m30STS is feasible and safe to evaluate lower extremity for moderate COVID-19 patients with SaO2 >95%. The absence of oxygen desaturation and increase in heart rate showed no increased oxygen consumption during the test. © 2021 Authors. |
COVID-19; Functional capacity; Modified 30-second sit-to-stand tes |
adult; Article; coronavirus disease 2019; cross-sectional study; female; functional status; heart rate; hospital department; human; isolation; length of stay; major clinical study; male; middle aged; mobilization; muscle strength; oxygen desaturation; oxygen saturation; prospective study; sit-to-stand test |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Article |
Q4 |
164 |
21905 |
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