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1	Widaty S., Sutarjo A.S., Wahid M.H., Darmawan I., Sitohang I.B.S.	57208261546;57221634021;57192887722;57395174200;56734569200;	The association between Malassezia spp. And pruritus in facial acne vulgaris	2021	Journal of Pakistan Association of Dermatologists	31	3		391	397		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122215594&partnerID=40&md5=d681f660e92c0b469e87702a23617193	Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Dermatology and Venereology, Dharmais Cancer Hospital-National Cancer Center, Jakarta, Indonesia; Department of Clinical Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Widaty, S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sutarjo, A.S., Department of Dermatology and Venereology, Dharmais Cancer Hospital-National Cancer Center, Jakarta, Indonesia; Wahid, M.H., Department of Clinical Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Darmawan, I., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sitohang, I.B.S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia	Background Acne vulgaris (AV) is a chronic inflammatory condition involving the pilosebaceous unit. Recent studies have shown that itching of mild-to-moderate severity is relatively common in patients with acne. Malassezia spp. is normal flora of skin surface, and can be found in acne lesions. Aim: To clarify the relationship between Malassezia spp. in facial acne lesions and their association with pruritus symptom. Methods This is a cross-sectional study conducted at dermatology and venereology outpatient clinic in a tertiary hospital in Indonesia. We recruited subjects with at least four inflammatory and four noninflammatory facial acne lesions. Acne was graded using Lehmann's criteria, and pruritus was graded using visual analog scale (VAS). Follicular content of acne lesions was collected for microscopic examination and fungal culture. Results Of the 120 subjects, 46 (38.3%) reported experiencing itching in acne lesions. Pruritus was more common in patients with mild AV. Among those with pruritus, fungal spore was found in 60.6% subjects. There was no statistically significant difference in terms of the presence and severity of pruritus and presence of Malassezia spp. determined by culture (p=0.332; 0.317). Conclusion Pruritus may accompany facial acne lesions. In this study, the presence and severity of pruritus did not correlate with the presence of Malassezia spp. in facial acne lesions. © 2021 Pakistan Association of Dermatologists. All rights reserved.	Acne vulgaris; Fungal spores; Malassezia; Pruritus; Skin disease	anti acne agent; acne vulgaris; adolescent; adult; Article; controlled study; cross-sectional study; disease association; disease severity; female; fungus culture; fungus spore; human; human tissue; Indonesia; major clinical study; Malassezia; male; microscopy; nonhuman; outpatient department; skin pruritus; tertiary care center; visual analog scale	Pakistan Association of Dermatologists	15609014		Article	Q4	129	25503	View
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2	Sudibio S., Anton J., Handoko H., Permata T.B.M., Kodrat H., Nuryadi E., Sofyan H.R., Mulyadi R., Aman R.A., Gondhowiardjo S.	57283461500;57328462500;57204105168;57197808751;57210639849;57197806814;57328366500;56403164500;36848942500;6508327402;	Outcome analysis and prognostic factors in patients of glioblastoma multiforme: An indonesian single institution experience	2021	Open Access Macedonian Journal of Medical Sciences	9			1410	1416		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119154241&doi=10.3889%2foamjms.2021.7502&partnerID=40&md5=9312ddc4112180679fb892c1d7cc2e79	Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Neurology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Neurosurgery, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia	Sudibio, S., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Anton, J., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Handoko, H., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Permata, T.B.M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Kodrat, H., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Nuryadi, E., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Sofyan, H.R., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Neurology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Mulyadi, R., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Aman, R.A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Neurosurgery, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Gondhowiardjo, S., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia	AIM: This study was done to assess the survival of patients with glioblastoma multiforme (GBM) and to identify factors that can affect patient survival. MATERIALS AND METHODS: From January 2015 to December 2019, 55 patients with histopathologically confirmed GBM and received adjuvant radiation/chemoradiation in our department were retrospectively analyzed. RESULTS: The median overall survival (OS) for entire cohort was 13 months and 1-year OS and 2-year OS rate were 52.7% and 3.6% with the mean follow-up period was 12 months. In univariate analysis, age (≤50 years vs. >50 years, p = 0.02), performance status (≥90 vs. 70–80 vs. <70, p < 0.001), radiation therapy oncology group recursive partitioning analysis (RTOG-RPA) classification (Class III vs. Class IV vs. Class V-VI, p < 0.001), parietal lobes tumor site (vs. others, p = 0.02), residual tumor volume (≤20.4 cm3 vs. >20.4 cm3, p = 0.001), and time to initiate adjuvant therapy (<4 weeks vs. 4-6 weeks vs. >6 weeks, p = 0.01) were significantly affect OS. In multivariate analysis, RTOG-RPA classification and involvement of parietal lobes were independent prognostic factors for OS. CONCLUSIONS: RTOG-RPA classification that consisted of age and performance status is an independent prognostic factor for the clinical outcome of GBM. Besides this well-known factor, we also identified the involvement of parietal lobe gives a strong negative influence on survival of GBM patients. © 2021 Sudibio Sudibio, Jellyca Anton, Handoko Handoko, Tiara Bunga Mayang Permata, Henry Kodrat, Endang Nuryadi, Henry Riyanto Sofyan, Rahmad Mulyadi, Renindra Ananda Aman, Soehartati Gondhowiardjo.	Glioblastoma multiforme; Prognostic factors; Radiotherapy; Survival	methylated DNA protein cysteine methyltransferase; adjuvant chemotherapy; adult; Article; basal ganglion; cancer prognosis; cancer radiotherapy; cancer size; cancer surgery; cancer survival; chemoradiotherapy; clinical outcome; cohort analysis; controlled study; corpus callosum; female; follow up; frontal lobe; glioblastoma; histopathology; human; human tissue; major clinical study; male; outcome assessment; overall survival; parietal lobe; prospective study; radiation dose; recursive partitioning; retrospective study; temporal lobe; tumor volume	Scientific Foundation SPIROSKI	18579655		Article	Q3	288	15252	View
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3	Taufiqa Z., Chandra D.N., Helmizar H., Lipoeto N.I., Hegar B.	57295694500;57190861000;57193098406;6507795270;6506273944;	Micronutrient content and total lactic acid bacteria of dadiah pudding as food supplementation for pregnant women	2021	Open Access Macedonian Journal of Medical Sciences	9			1149	1155		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117031213&doi=10.3889%2foamjms.2021.6791&partnerID=40&md5=41ee51317717c3162ced81a45aa47265	Department of Nutrition, Doctoral Program, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Medical Education Unit, Faculty of Medicine, Universitas Andalas, Padang, 25144, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Department of Nutrition, Faculty of Public Health, Universitas Andalas, Padang, 25144, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Andalas, Padang, 25144, Indonesia; Department of Pediatrics, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia	Taufiqa, Z., Department of Nutrition, Doctoral Program, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Medical Education Unit, Faculty of Medicine, Universitas Andalas, Padang, 25144, Indonesia; Chandra, D.N., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Helmizar, H., Department of Nutrition, Faculty of Public Health, Universitas Andalas, Padang, 25144, Indonesia; Lipoeto, N.I., Department of Nutrition, Faculty of Medicine, Universitas Andalas, Padang, 25144, Indonesia; Hegar, B., Department of Pediatrics, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia	BACKGROUND: Dadiah, traditional yogurt from Indonesia, which is known as a source of probiotics, also contains micronutrients. AIM: This descriptive study aimed to determine whether additional ingredients and processes during the manufacture of Dadiah pudding maintain the iron, zinc, calcium, and total lactic acid bacteria (LAB) contents. METHODS: Dadiah pudding was made using Dadiah originated from Bukittinggi, West Sumatra. Micronutrient levels were analyzed according to Indonesian National Standard 01-2896-1998. The total LAB were counted by inoculating samples on Man, Rogosa, and Sharpe agar with serial dilution, and morphological identification was carried out using gram stain. RESULTS: In 100 g of original Dadiah, mango and chocolate Dadiah pudding contained 347.98, 276.61, and 279.29 mg of calcium; 4.87, 3.75, and 6.31 mg of zinc; 6.53, 6.60, and 9.39 mg of iron; and 6.4 × 10⁹, 6.1 × 10⁹, and 2.4 × 10⁹ CFU/ml LAB, respectively. CONCLUSION: This study found that modifying the original Dadiah into Dadiah pudding has been proved to affect the concentration of calcium, zinc, and iron and to maintain total LAB. We suggest that consuming Dadiah pudding may be a good choice as a food supplementation for pregnant women to optimize the golden period outcomes. © 2021 Zuhrah Taufiqa, Dian Novita Chandra, Helmizar Helmizar, Nur Indrawaty Lipoeto, Badriul Hegar.	Dadiah pudding; Lactic acid bacteria; Micronutrients; Pregnant women; Probiotic	calcium; iron; probiotic agent; trace element; yoghurt; zinc; adult; Article; bacterial count; colony forming unit; controlled study; dietary supplement; double blind procedure; female; fermentation; fermented product; food frequency questionnaire; food industry; gestational age; Gram staining; health center; human; human experiment; Indonesia; informed consent; lactic acid bacterium; microbial morphology; micronutrient intake; middle aged; normal human; pregnancy outcome; pregnant woman; randomized controlled trial; young adult	Scientific Foundation SPIROSKI	18579655		Article	Q3	288	15252	View
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4	Rinaldi I., Putri A., Louisa M., Koesnoe S.	23475122400;57214826648;41461551400;26028015000;	High stat5a expression is associated with major molecular response achievement failure of chronic phase chronic myeloid leukemia patients receiving hydroxyurea before imatinib: A cross-sectional study	2021	Open Access Macedonian Journal of Medical Sciences	9			1160	1167		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117030211&doi=10.3889%2foamjms.2021.6911&partnerID=40&md5=f2aaf46fdf0c34ecbeb60cc8e6d66cac	Department of Internal Medicine, Division of Hematology and Medical Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Division of Allergy and Clinical Immunology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia	Rinaldi, I., Department of Internal Medicine, Division of Hematology and Medical Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Putri, A., Department of Internal Medicine, Division of Hematology and Medical Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Koesnoe, S., Department of Internal Medicine, Division of Allergy and Clinical Immunology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia	BACKGROUND: STAT5 is a transcriptional factor which when highly expressed in chronic myeloid leukemia (CML) cells stimulate proliferation and mediate resistance from tyrosine kinase inhibitors, resulting in major molecular response (MMR) failure. STAT5 has two isoforms, STAT5A and STAT5B. However, prolonged use of imatinib appears to only upregulate STAT5A pathway. In addition, the resistance conferred by STAT5A does not extend to other drugs such as hydroxyurea. Hence, STAT5A and STAT5B might have different functions in CML cells. AIM: The objective of the study was to determine the association of STAT5A and STAT5B expression with MMR failure in CML patients. METHODS: This was a cross-sectional study of CML patients in chronic phase with age ≥ 18 years old, receiving IM therapy ≥ 12 months, and previously given hydroxyurea. MMR status was evaluated and patients were categorized as achieved or failed to achieve MMR. Expression levels of STAT5A and STAT5B were conducted using RT-PCR methods. Associations between STAT5A expression, STAT5B expression, hydroxyurea duration, and imatinib duration with MMR achievement were calculated using logistic regression. RESULTS: A total of 118 patients were analyzed; 71.1% failed to achieve MMR. Multivariate logistic regression analysis showed statistically significant association between high STAT5A expression (odds ratio [OR]: 3.852; 95% confidence interval [CI]: 1.420–10.452; p = 0.008), STAT5A/STAT5B interaction (OR: 0.150; 95% CI: 0.038–0.593; p = 0.007), longer hydroxyurea administration (OR: 3.882; 95% CI: 1.023–14.733; p = 0.046), and shorter imatinib administration (OR: 0.333; 95% CI: 0.132–0.840; p = 0.020) with MMR achievement failure. After adjusting STAT5A expression with STAT5A/STAT5B interaction, high STAT5A expression independently increased the likelihood of MMR achievement failure only in high expression STAT5B patients (OR: 3.852; 95% CI: 1.420–10.452; p = 0.008). CONCLUSION: High STAT5A expression which is induced by high STAT5B is associated with MMR achievement failure of chronic phase CML patients who received hydroxyurea before imatinib. Longer duration of hydroxyurea and shorter duration of IM confound of STAT5A expression to MMR achievement failure. © 2021 Ikhwan Rinaldi, Anastasia Putri, Melva Louisa, Sukamto Koesnoe.	Breakpoint cluster region-ABL; Chronic myeloid leukemia; Imatinib; STAT5A; STAT5B	eltrombopag; hemoglobin; hydroxyurea; imatinib; STAT5 protein; adult; age; Article; basophil; blood sampling; chronic myeloid leukemia; cross-sectional study; female; gene amplification; housekeeping gene; human; human cell; human experiment; leukocyte; lymphocyte; major clinical study; male; middle aged; neutrophil; overall survival; platelet count; protein expression; real time polymerase chain reaction; sex; thrombocyte	Scientific Foundation SPIROSKI	18579655		Article	Q3	288	15252	View
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5	Rahmat B., Dwita N.U., Arya Wardana P.W., Lilyasari O.	57192273755;57402910300;57403605200;57192914838;	Preoperative Left Ventricle End Diastolic Volume Index as a Predictor for Low Cardiac Output Syndrome After Surgical Closure of Secundum Atrial Septal Defect With Small-Sized Left Ventricle	2021	Frontiers in Pediatrics	9		705257				https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122447256&doi=10.3389%2ffped.2021.705257&partnerID=40&md5=6da645c8d6ae19fd8dfd4e9dc9a05bcb	Pediatric and Congenital Heart Surgery Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Centre Harapan Kita, Jakarta, Indonesia	Rahmat, B., Pediatric and Congenital Heart Surgery Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Dwita, N.U., Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Arya Wardana, P.W., Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Lilyasari, O., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Centre Harapan Kita, Jakarta, Indonesia	Introduction: Low cardiac output syndrome is one of the postoperative complications that are associated with significant morbidity and mortality after surgical closure of atrial septal defect (ASD) with small-sized left ventricle (LV). This study investigated whether preoperative left ventricular end-diastolic volume index (LVEDVi) could accurately predict low cardiac output syndrome (LCOS) after surgical closure of ASD with small-sized LV. Method: This retrospective cohort study involved adult ASD patients with small-sized LV from January 2018 to December 2019 in National Cardiovascular Center Harapan Kita. Preoperative MRI data to assess the left and right ventricle volume were collected. A bivariate analysis using independent Student's t-test was done. Diagnostic test using receiver operating characteristic (ROC) curve was also done to obtain the area under the curve (AUC) value. The best cutoff point was determined by Youden's index. Result: Fifty-seven subjects were involved in this study [age (mean ± SD) 32.56 ± 13.15 years; weight (mean ± SD) 48.82 ± 12.15 kg]. Subjects who had post-operative LCOS (n = 30) have significantly lower LVEDVi (45.0 ± 7.42 ml/m2 vs. 64.15 ± 13.37 ml/m2; p < 0.001), LVEDV (64.6 ± 16.0 ml vs. 85.9 ± 20.7 ml; p < 0.001), LVSV (38.97 ± 11.5 ml vs. 53.13 ± 7.5 ml; p < 0.001), and LVSVi (27.28 ± 8.55 ml/m2 vs. 37.42 ± 5.35 ml/m2; p < 0.001) compared to subjects who did not have post-operative LCOS (n = 27). ROC analysis showed that the best AUC was found on LVEDVi (AUC 95.3%; 95% confidence interval: 90.6–100%). The best cutoff value for LVEDVi to predict the occurrence of LCOS after surgical closure of ASD was 53.3 ml/m2 with a sensitivity of 86.7% and a specificity of 85.2%. Conclusion: This study showed that preoperative LVEDVi could predict LCOS after surgical closure of ASD with small-sized LV with a well-defined cutoff. The best cutoff value of LVEDVi to predict the occurrence of LCOS after surgical ASD closure was 53.5 ml/m2. Copyright © 2021 Rahmat, Dwita, Arya Wardana and Lilyasari.	ASD closure; atrial septal defect; left ventricle end diastolic volume; low cardiac output syndrome; magnetic resonance imaging (MRI)		Frontiers Media S.A.	22962360		Article	Q1	960	4641	View
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6	Pranata R., Huang I., Lim M.A., Yonas E., Vania R., Lukito A.A., Nasution S.A., Siswanto B.B., Kuswardhani R.A.T.	57201973901;57208576645;57216039756;57201987097;57208328436;57213835420;57189373134;14422648800;36863900500;	Elevated De Ritis Ratio Is Associated With Poor Prognosis in COVID-19: A Systematic Review and Meta-Analysis	2021	Frontiers in Medicine	8		676581			1	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122327729&doi=10.3389%2ffmed.2021.676581&partnerID=40&md5=254957cc5c17b448a803a88e33741d8f	Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Faculty of Medicine, Department of Internal Medicine, Hasan Sadikin General Hospital, Universitas Padjadjaran, Bandung, Indonesia; Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Faculty of Medicine, Division of Plastic, Reconstructive, and Aesthetic, Department of Surgery, Sanglah General Hospital, Udayana University, Jimbaran, Indonesia; Department of Cardiology and Vascular Medicine, Siloam Hospitals Lippo Village, Tangerang, Indonesia; Faculty of Medicine, Division of Cardiology, Department of Internal Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Faculty of Medicine, Department of Cardiology and Vascular Medicine, National Cardiovascular Center Harapan Kita, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Division of Geriatrics, Department of Internal Medicine, Sanglah Teaching Hospital, Udayana University, Denpasar, Indonesia	Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Huang, I., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Faculty of Medicine, Department of Internal Medicine, Hasan Sadikin General Hospital, Universitas Padjadjaran, Bandung, Indonesia; Lim, M.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Yonas, E., Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Vania, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Faculty of Medicine, Division of Plastic, Reconstructive, and Aesthetic, Department of Surgery, Sanglah General Hospital, Udayana University, Jimbaran, Indonesia; Lukito, A.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Department of Cardiology and Vascular Medicine, Siloam Hospitals Lippo Village, Tangerang, Indonesia; Nasution, S.A., Faculty of Medicine, Division of Cardiology, Department of Internal Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Siswanto, B.B., Faculty of Medicine, Department of Cardiology and Vascular Medicine, National Cardiovascular Center Harapan Kita, Universitas Indonesia, Jakarta, Indonesia; Kuswardhani, R.A.T., Faculty of Medicine, Division of Geriatrics, Department of Internal Medicine, Sanglah Teaching Hospital, Udayana University, Denpasar, Indonesia	Objective: This meta-analysis aims to assess whether elevated De Ritis ratio is associated with poor prognosis in patients with coronavirus 2019 (COVID-19). Methods: A systematic literature search was performed using PubMed, Embase, and EuropePMC databases up until September 17, 2021. De Ritis ratio is also known as Aspartate aminotransferase/alanine transaminase (AST/ALT) ratio. The main outcome was poor prognosis, a composite of mortality, severity, the need for ICU care, and intubation. The effect measure was odds ratios (ORs) and mean differences. We generated sensitivity and specificity, negative and positive likelihood ratio (NLR and PLR), diagnostic odds ratio (DOR), and area under curve (AUC). Results: There were eight studies with 4,606 patients. De Ritis ratio was elevated in 44% of the patients. Patients with poor prognosis have higher De Ritis ratio [mean difference 0.41 (0.31, 0.50), p < 0.001; I2: 81.0%] and subgroup analysis showed that non-survivors also have higher De Ritis Ratio [mean difference 0.47 (0.46, 0.48), p < 0.001; I2: 0%]. Elevated De Ritis ratio was associated with poor prognosis [OR 3.28 (2.39, 4.52), p < 0.001; I2: 35.8%]. It has a sensitivity of 55% (36–73), specificity of 71% (52–85), PLR 1.9, NLR.63, DOR of 3 (2–4), and AUC of.67 (0.63–0.71). The posterior probability of poor prognosis was 38% if De Ritis is elevated, while 17% if De Ritis is not elevated. Conclusion: Elevated De Ritis ratio is associated with poor prognosis in patients with COVID-19. Systematic Review Registration: PROSPERO ID: CRD42020216634. Copyright © 2021 Pranata, Huang, Lim, Yonas, Vania, Lukito, Nasution, Siswanto and Kuswardhani.	coronavirus—COVID-19; De Ritis ratio; liver enzyme; SARS-CoV-2; transaminase		Frontiers Media S.A.	2296858X		Review	Q1	1388	2608	View
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7	Wisnu W., Alwi I., Nafrialdi N., Harimurti K., Pemayun T.G.D., Jusman S.W.A., Santoso D.I.S., Harahap A.R., Suwarto S., Subekti I.	57200425452;15055173800;57395824800;23473513200;57208091289;36518792100;6604001213;57395521700;8443626100;24336854300;	The Differential Effects of Propylthiouracil and Methimazole as Graves’ Disease Treatment on Vascular Atherosclerosis Markers: A Randomized Clinical Trial	2021	Frontiers in Endocrinology	12		796194				https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122186237&doi=10.3389%2ffendo.2021.796194&partnerID=40&md5=f92b3a12a849c6a2e102b7358c8abd20	Division of Endocrine, Metabolism and Di, abetes, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Division of Endocrine, Metabolism, and Diabetes, Department of Internal Medicine, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Physiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia	Wisnu, W., Division of Endocrine, Metabolism and Di, abetes, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Alwi, I., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Nafrialdi, N., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Harimurti, K., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Pemayun, T.G.D., Division of Endocrine, Metabolism, and Diabetes, Department of Internal Medicine, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Jusman, S.W.A., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Santoso, D.I.S., Department of Medical Physiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Harahap, A.R., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Suwarto, S., Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Subekti, I., Division of Endocrine, Metabolism and Di, abetes, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia	Background: Hyperthyroidism is related to vascular atherosclerosis. Propylthiouracil (PTU) and methimazole, other than their antithyroid effects, may have different mechanisms in preventing atherogenesis in Graves’ disease. Objective: This study aimed to investigate the effect of antithyroid drugs on markers of vascular atherosclerosis in Graves’ hyperthyroidism. Methods: This study was a single-blind, randomized clinical trial conducted on 36 patients with Graves’ disease in Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, from June 2019 until July 2020. Graves’ disease was diagnosed from clinical manifestation of hyperthyroidism with diffuse goiter and then confirmed by thyroid stimulation hormone (TSH), free T4 (fT4), and TSH-receptor antibody (TRAb) measurements. Participants were randomly assigned to either a PTU or a methimazole treatment group and followed up for 3 months. Markers of vascular atherosclerosis were represented by adhesion molecules [intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin], carotid artery stiffness [pulse wave velocity (PWV)], and thickness [carotid intima media thickness (cIMT)]. Results: By the end of the study, 24 participants reached euthyroid condition (13 from the PTU group and 11 from the methimazole group). After 3 months of follow-up, in the PTU group, we noticed an improvement of ICAM-1 [pretreatment: 204.1 (61.3) vs. posttreatment: 141.6 (58.4) ng/ml; p = 0.001], VCAM-1 [837 (707–977) vs. 510 (402–630) ng/ml; p < 0.001] and E-selectin [32.1 (24.1–42.7) vs. 28.2 (21.6–36.8) ng/ml; p = 0.045] in the PTU group. In the methimazole group, only VCAM-1 improvement [725 (565–904) vs. 472 (367–590); p = 0.001] was observed. Meanwhile, we found no significant changes in PWV or cIMT in either group. Conclusion: Antithyroid treatment in Graves’ disease leads to improvement in adhesion molecules, with a lesser effect on methimazole, whereas there were no significant changes in PWV or cIMT. PTU may have a better mechanism compared with methimazole in terms of improving adhesion molecules. Copyright © 2021 Wisnu, Alwi, Nafrialdi, Harimurti, Pemayun, Jusman, Santoso, Harahap, Suwarto and Subekti.	adhesion molecules; carotid intima media thickness; Graves’ disease; hyperthyroidism; methimazole; propylthiouracil; pulse wave velocity; vascular atherosclerosis	cell adhesion molecule 1; endothelial leukocyte adhesion molecule 1; propylthiouracil; thiamazole; thyrotropin; adolescent; adult; arterial stiffness; Article; atherosclerosis; blood pressure; clinical article; controlled study; coronavirus disease 2019; echography; electrochemiluminescence immunoassay; enzyme linked immunosorbent assay; female; follow up; Graves disease; human; hyperthyroidism; inflammation; male; middle aged; physical examination; pregnancy; pulse wave velocity; randomized controlled trial; young adult	Frontiers Media S.A.	16642392		Article	Q1	1518	2233	View
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8	Sartika D., Nurrachmah E., Sukirman D.I., Mansyur M., Supartono B.	57467276300;57466703100;57467568600;37085506800;57205286040;	Ergonomic Risk-prone Activities toward Nurses in the Intensive Care and Emergency Room	2021	Open Access Macedonian Journal of Medical Sciences	9	T5		48	53		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125269929&doi=10.3889%2fOAMJMS.2021.7851&partnerID=40&md5=e4f606505a7f1d2f7fa6498e532fb934	Health Polytechnic of Riau, Pekanbaru, Indonesia; Department of Medical Surgery, Faculty of Nursing, University of Indonesia, Jakarta, Indonesia; Department of Basic Science and Fundamentals of Nursing, Faculty of Nursing, University of Indonesia, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Faculty of Medicine, Pembangunan Nasional University, Jakarta, Indonesia	Sartika, D., Health Polytechnic of Riau, Pekanbaru, Indonesia; Nurrachmah, E., Department of Medical Surgery, Faculty of Nursing, University of Indonesia, Jakarta, Indonesia; Sukirman, D.I., Department of Basic Science and Fundamentals of Nursing, Faculty of Nursing, University of Indonesia, Jakarta, Indonesia; Mansyur, M., Department of Community Medicine, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Supartono, B., Faculty of Medicine, Pembangunan Nasional University, Jakarta, Indonesia	BACKGROUND: Nurses have the risk of ergonomic hazards in providing nursing care, especially with increasingly dynamic health services such as during Coronavirus disease-19 pandemic like today. AIM: The aim of the study was to evaluate activities prone to produce ergonomic risks during the implementation of nursing care in intensive care and emergency room (ER) of a hospital in Riau, Indonesia. METHODOLOGY: This study was conducted by observing the routine activities conducted by the nurses and using similar task group techniques equipped with Rapid Entire Body Assessment instrument. Those observed activities were obtained from 17 intensive care room nurses and ten ER nurses. There were six activities observed in the intensive care room: Bathing, transferring the patient, wounds dressing, taking blood samples for the AGDA examinations, as well as inserting the intravenous needle and electrocardiograms. Meanwhile, there were two activities observed in the ER: Transferring the patient and inserting the intravenous needle. RESULTS: The highest ergonomic risks activity in the intensive care room was bathing the patient with a total score of 13. At the ER, the highest risk score was transferring the patient with a total score of 12. Both activities were at level 4, indicating a high-risk condition. Thus, examinations and changes should be immediately initiated. CONCLUSION: The results are significant to be paid attention by the related parties at the hospital to facilitate some improvements immediately. In addition, the ergonomic approaches that can be suggested to the nurses are regular stretching, physical exercises, and applying ergonomic principles while working. © 2021 Dewi Sartika, Elly Nurrachmah, Dewi Irawaty Sukirman, Muchtaruddin Mansyur, Basuki Supartono.	Emergency room; Ergonomic risk; Intensive care; Nurse’s activity; Nursing intervention		Scientific Foundation SPIROSKI	18579655		Article	Q3	288	15252	View
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9	Wahidiyat P.A., Yo E.C., Wildani M.M., Triatmono V.R., Yosia M.	24400464000;57213188908;57223404540;57225083843;57204933098;	Cross-sectional study on knowledge, attitude and practice towards thalassaemia among Indonesian youth	2021	BMJ Open	11	12	e054736				https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121204786&doi=10.1136%2fbmjopen-2021-054736&partnerID=40&md5=254c5b647a17fbed23378ced6a556eb2	Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Hematology and Oncology, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Wahidiyat, P.A., Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Hematology and Oncology, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Indonesia; Yo, E.C., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wildani, M.M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Triatmono, V.R., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yosia, M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Introduction Thalassaemia is an inherited blood disorder, for which definitive treatments remain largely inaccessible. The recommended approach to reduce the disease burden is by prevention through screening. Currently, the implementation of thalassaemia preventive measures is poorly regulated in Indonesia. Thalassaemia prevention and education are best targeted to the youth, but information on their awareness towards thalassaemia is limited. This study aims to investigate the knowledge, attitude and practice (KAP) towards thalassaemia among Indonesian youth. Methods This observational study took place between January and May 2021. An online questionnaire was disseminated to Indonesian youth aged 15-24. Eligible respondents included carriers, unaffected individuals and individuals with unknown carrier status. The questionnaire comprised 28 questions to assess KAP. A cut-off of 75% was used to categorise participant's KAP into poor or negative and good or positive. Descriptive statistics, χ 2 test, logistic regression and Pearson correlation were performed for data analysis. Results A total of 906 responses were gathered, and 878 were analysed. Most respondents had poor knowledge (62.1%), positive attitude (83.3%) and poor practice (54.4%) towards thalassaemia. The results implied that respondents had limited understanding regarding the types of thalassaemia and the difference between asymptomatic carriers and individuals without the thalassaemia trait. Many (82.6%) believed they were not carrying thalassaemia trait despite the fact that most (95.7%) never got tested. Age, education, gender, residence and family income were key factors that correlated with or predicted the youth's KAP towards thalassaemia. Older respondents and women were more likely to have good KAP. Conclusion Thalassaemia screening targeted to the youth is urgently needed, and future interventions must consider sociodemographic factors that may affect how they perceive the disease. Social media appeals to the youth as an important source of information, but school, parents and health professionals should also be involved in delivering education about thalassaemia. © BMJ Publishing Group Limited 2021.	community child health; haematology; paediatrics; public health	adolescent; adult; age distribution; Article; asymptomatic carrier; attitude to health; bone marrow transplantation; child health; controlled study; cross-sectional study; demography; educational status; family income; female; gene therapy; human; Indonesia; juvenile; leukemia; major clinical study; male; observational study; questionnaire; screening test; self concept; sex difference; thalassemia; thalassemia major	BMJ Publishing Group	20446055	34862299	Article	Q1	1132	3624	View
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10	Lee Y.-S., Oh Y.S., Choi E.-K., Chern A.K.C., Jiampo P., Chutinet A., Hanafy D.A., Trivedi P., Zhai D.	57369401600;14021940000;35558194200;57219941181;57219936937;15724336700;55431326800;57219936294;57219941292;	Patient perception and treatment convenience of dabigatran versus vitamin K antagonist when used for stroke prophylaxis in atrial fibrillation: Real-world Evaluation of Long-term Anticoagulant Treatment Experience (RE-LATE) study	2021	Open Heart	8	2	e001745				https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121029837&doi=10.1136%2fopenhrt-2021-001745&partnerID=40&md5=604033aab18ff9417453572cb72e2905	Department of Internal Medicine, Daegu Catholic University College of Medicine, Daegu, South Korea; Department of Internal Medicine, Catholic University of Korea, Seoul, South Korea; Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea; Department of Cardiology, Columbia Asia Hospital, Taiping, Malaysia; Department of Medicine, Bhumibol Adulyadej Hospital, Bangkok, Thailand; Chulalongkorn Stroke Center, King Chulalongkorn Memorial Hospital, Bangkok, Thailand; Division of Neurology, Department of Medicine, Chulalongkorn University, Bangkok, Thailand; Cardiology and Vascular Medicine, Pusat Jantung Nasional Harapan Kita, Jakarta, Indonesia; Cardiology and Vascular Medicine, University of Indonesia Faculty of Medicine, Jakarta, Indonesia; Boehringer Ingelheim Singapore Pte Ltd, Singapore, Singapore; Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT, United States	Lee, Y.-S., Department of Internal Medicine, Daegu Catholic University College of Medicine, Daegu, South Korea; Oh, Y.S., Department of Internal Medicine, Catholic University of Korea, Seoul, South Korea; Choi, E.-K., Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea; Chern, A.K.C., Department of Cardiology, Columbia Asia Hospital, Taiping, Malaysia; Jiampo, P., Department of Medicine, Bhumibol Adulyadej Hospital, Bangkok, Thailand; Chutinet, A., Chulalongkorn Stroke Center, King Chulalongkorn Memorial Hospital, Bangkok, Thailand, Division of Neurology, Department of Medicine, Chulalongkorn University, Bangkok, Thailand; Hanafy, D.A., Cardiology and Vascular Medicine, Pusat Jantung Nasional Harapan Kita, Jakarta, Indonesia, Cardiology and Vascular Medicine, University of Indonesia Faculty of Medicine, Jakarta, Indonesia; Trivedi, P., Boehringer Ingelheim Singapore Pte Ltd, Singapore, Singapore; Zhai, D., Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT, United States	Purpose Dabigatran is a direct thrombin inhibitor approved for stroke prophylaxis in patients with non-valvular atrial fibrillation (NVAF). Real-world data about patient preference, satisfaction and convenience in patients in Asia are not available. The study aimed to explore the perception of patients with newly diagnosed NVAF regarding dabigatran versus vitamin K antagonists (VKAs), when used for stroke prevention. Patients and methods This was a multinational, multicentre, non-interventional study involving 49 sites across 5 countries in South East Asia and South Korea where 934 patients newly diagnosed with NVAF were initiated on either dabigatran (N=591) or VKA (N=343). Data were collected at baseline and over two follow-up visits across 6 months. Treatment satisfaction and patient convenience were evaluated using the Perception on Anticoagulant Treatment Questionnaire-2 (PACT-Q2). Results The mean age of the patients was 65.9±10.4 years, and 64.2% were male. Mean CHA 2 DS 2-VASc score was 2.4±1.5, and mean HAS-BLED score was 1.2±0.9. At baseline, patients initiated on dabigatran had higher stroke risk, bleeding risk, creatinine clearance and proportion of patients with concomitant illnesses compared with patients initiated on VKAs. Treatment convenience was perceived to be significantly better with dabigatran versus VKAs at visits 2 and 3 (p=0.0423 and 0.0287, respectively). Treatment satisfaction was significantly better with dabigatran compared with VKAs at visit 3 (p=0.0300). Conclusion In this study, dabigatran is associated with better patient perception in terms of treatment convenience and satisfaction compared with VKAs when used for stroke prevention in newly diagnosed NVAF patients from South East Asia and South Korea. Plain language summary Patient satisfaction with dabigatran versus VKAs in South East Asia. Patients with atrial fibrillation are at high risk of stroke and require anticoagulants for stroke prevention. Two such anticoagulants are dabigatran and VKAs. We wanted to compare the extent of satisfaction and treatment convenience among newly diagnosed patients with atrial fibrillation from the South East Asian region when they were given either dabigatran or VKAs. Consenting patients filled out a standardised questionnaire called the PACT-Q2 over three visits after they were started on either dabigatran (591 patients) or VKAs (343 patients). We found that satisfaction and convenience were significantly higher when patients received dabigatran than when they received VKAs. © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.	Atrial fibrillation; Health care; Outcome assessment; Stroke		BMJ Publishing Group	2398595X		Article	Q1	1050	4080	View

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