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6 |
Soetisna T.W.; Thamrin A.M.H.; Ramadhani A.N.E.; Permadijana D.; Elfian M.A.; Hendarto H. |
Soetisna, Tri Wisesa (57214887740); Thamrin, Ahmad Muslim Hidayat (58192261300); Ramadhani, Andi Nurul Erisya (58489887400); Permadijana, Diajeng (58492411600); Elfian, Muhammad Alghifari (59152843500); Hendarto, Hari (55206713900) |
57214887740; 58192261300; 58489887400; 58492411600; 59152843500; 55206713900 |
Systematic Review of Stem Cell Therapy for Ischemic Heart Disease in Indonesia: Where Are We Now? |
2024 |
Malaysian Journal of Medicine and Health Sciences |
20 |
3 |
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298 |
306 |
8 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85194956672&doi=10.47836%2fmjmhs.20.3.40&partnerID=40&md5=9142c7b56db0c3e4b8b7a22981bd7e4e |
Adult Cardiac Surgery Division, Department of Thoracic and Cardiovascular Surgery, Harapan Kita National Cardiovascular Center Hospital, Jakarta, Indonesia; Faculty of Medicine Syarif Hidayatullah State Islamic University, Haji Hospital, Jakarta, Indonesia; Department of Thoracic and Cardiovascular Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Soetisna T.W., Adult Cardiac Surgery Division, Department of Thoracic and Cardiovascular Surgery, Harapan Kita National Cardiovascular Center Hospital, Jakarta, Indonesia, Faculty of Medicine Syarif Hidayatullah State Islamic University, Haji Hospital, Jakarta, Indonesia; Thamrin A.M.H., Adult Cardiac Surgery Division, Department of Thoracic and Cardiovascular Surgery, Harapan Kita National Cardiovascular Center Hospital, Jakarta, Indonesia, Department of Thoracic and Cardiovascular Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Ramadhani A.N.E., Adult Cardiac Surgery Division, Department of Thoracic and Cardiovascular Surgery, Harapan Kita National Cardiovascular Center Hospital, Jakarta, Indonesia; Permadijana D., Adult Cardiac Surgery Division, Department of Thoracic and Cardiovascular Surgery, Harapan Kita National Cardiovascular Center Hospital, Jakarta, Indonesia; Elfian M.A., Adult Cardiac Surgery Division, Department of Thoracic and Cardiovascular Surgery, Harapan Kita National Cardiovascular Center Hospital, Jakarta, Indonesia; Hendarto H., Department of Thoracic and Cardiovascular Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Introduction: Heart failure due to IHD is one of the most common causes of morbidity in Indonesia. The promising stem cell therapy for IHD patients has been conducted in Indonesia since 12 years ago but limited results of publications are available. We conducted a systematic review to evaluate the progress of stem cell therapy for IHD patients in Indonesia. Methods: A systematic review was conducted according to the PRISMA guidelines. A comprehensive literature search was performed using the PubMed, Scopus, and Embase databases from March – April 2023. Articles are thoroughly evaluated and analyzed. Results: Four publications from Indonesia related to stem cell therapy for IHD patients are included. Clinical outcome was measured by LVEF, WMSI, and 6-MWT. Safety outcomes are also measured. Follow-up time ranged from 6 – 12 months. Significant improvement in most of the LVEF, WMSI, and 6-MWT studies. Safety outcome measures demonstrated relatively low rates of AE after stem cell transplantation and no cardiac event-related deaths were reported. Conclusion: Stem cell therapy trials for IHD in Indonesia show promising results in improving ventricular function and daily functional outcomes safely. With the fast-growing trend of stem cells and cardiovascular centers in Indonesia, we hope that more well-designed clinical trials with long-term outcome assessments can be conducted to confirm these results. © 2024 Universiti Putra Malaysia Press. All rights reserved. |
Indonesia; Ischemic heart disesase; Outcome; Safety; Sstem cell |
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Universiti Putra Malaysia Press |
16758544 |
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Article |
Q4 |
139 |
22705 |
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7 |
Lubis A.M.T.; Prasetyo J.; Canintika A.F. |
Lubis, Andri Maruli Tua (15122639800); Prasetyo, Joseph (59002254800); Canintika, Anissa Feby (57208821931) |
15122639800; 59002254800; 57208821931 |
Isolated posterior cruciate ligament tears in monozygotic twins: A case report |
2024 |
International Journal of Surgery Case Reports |
119 |
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109682 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85191328847&doi=10.1016%2fj.ijscr.2024.109682&partnerID=40&md5=0972bb4f235ecada673c2cd82a8c8625 |
Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Lubis A.M.T., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Prasetyo J., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Canintika A.F., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction and importance: Posterior cruciate ligament (PCL) tears are not as frequent as anterior cruciate ligament (ACL) tears. They are rare as an isolated injury and more commonly occur in a multi-ligament-injured knee. We reported a case of rupture of PCL in monozygotic twins. Case presentation: A 19-year-old female presented with giving away of her left knee since 4 months ago. She fell from stairs previously. Physical examination demonstrated positive posterior drawer test. Magnetic resonance imaging showed ruptured PCL and lateral meniscal tear. Two months later, her identical twin, also a 19-year old-female, fell from the stairs and complained of giving away. Physical examination showed positive posterior drawer test. Magnetic resonance imaging demonstrated ruptured PCL and lateral meniscal tear. Both patients underwent arthroscopic-assisted PCL reconstruction using gracilis, semitendinosus, and peroneus tendon graft. At one year of follow-up, there were no graft failures. The twins had satisfactory outcome measured by Osteoarthritis Outcome Score (KOOS) and visual analogue scale (VAS). Both were athletes prior to their injury and they returned to sport. Clinical discussion: Although it has never been reported before, this report shows that patients may have genetic predisposition to the incidence of PCL rupture. This is likely because of heritable factors, such as biomechanical, anatomic, anthropometric, and neuromuscular traits. A family history of PCL tear may increase the risk of a PCL tear. Further studies are recommended to examine genetic variants as a risk factor for PCL tears and other knee disorders. Conclusions: Multiple variables may lead to the increased risk of these twins: the combination of improper neuromuscular control, genetic factors, and possibly hormonal factors contributed to their PCL injuries. Further history exploration, lab tests, and genetic analysis should be done to determine the variables. Both patients returned to sports protocol testing and returned to sports one year postoperatively. © 2024 |
Monozygotic twins; Posterior cruciate ligament tear |
adult; arthroscopic surgery; Article; athlete; case report; clinical article; female; follow up; gracilis muscle; human; Knee Injury and Osteoarthritis Outcome Score; knee meniscus rupture; lateral meniscus; monozygotic twins; nuclear magnetic resonance imaging; peroneal muscle; physical examination; posterior cruciate ligament reconstruction; posterior cruciate ligament rupture; quadriceps femoris muscle; return to sport; semitendinous muscle; tendon graft; visual analog scale; young adult |
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Elsevier Ltd |
22102612 |
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Article |
Q3 |
193 |
19555 |
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8 |
Kurniawan J.; Teressa M.; Budiman R.A.; Matondang S.B.R.E. |
Kurniawan, Juferdy (57193251655); Teressa, Maria (57957998500); Budiman, Refael Alfa (57224981676); Matondang, Sahat Basana Romanti Ezer (57192085914) |
57193251655; 57957998500; 57224981676; 57192085914 |
Transarterial embolization with bleomycin–lipiodol emulsion: a successful minimal invasive approach for giant liver hemangioma |
2024 |
Clinical Journal of Gastroenterology |
17 |
3 |
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511 |
514 |
3 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85188537891&doi=10.1007%2fs12328-024-01948-5&partnerID=40&md5=c4c65b2e468658770d3f506ee3cefed8 |
Division of Hepatobiliary, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia; Department of Radiology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Kurniawan J., Division of Hepatobiliary, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia; Teressa M., Division of Hepatobiliary, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia; Budiman R.A., Division of Hepatobiliary, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia; Matondang S.B.R.E., Department of Radiology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Hemangiomas are most common benign liver tumor. Most patients have an excellent prognosis because of the small size and benign nature of tumor. On some occasions, giant liver hemangioma may cause symptoms and significant challenges due to its complication. We report a case of giant liver hemangioma treated with minimal invasive approach by transarterial embolization (TAE). Following three TAE sessions over a specific timeframe, the patient was successfully managed, addressing that TAE may be a useful alternative to hepatic surgery in such cases. © Japanese Society of Gastroenterology 2024. |
Giant hemangioma; Liver hemangioma; TAE; Transarterial embolization |
Antibiotics, Antineoplastic; Bleomycin; Chemoembolization, Therapeutic; Embolization, Therapeutic; Emulsions; Ethiodized Oil; Female; Hemangioma; Humans; Liver Neoplasms; Male; Middle Aged; alanine aminotransferase; aspartate aminotransferase; bleomycin; iodinated poppyseed oil; nuclear magnetic resonance imaging agent; proton pump inhibitor; antineoplastic antibiotic; bleomycin; iodinated poppyseed oil; abdominal discomfort; adult; Article; artificial embolization; bloating; body weight loss; case report; clinical article; female; fever; human; liver hemangioma; middle aged; minimally invasive surgery; nuclear magnetic resonance imaging; physical examination; chemoembolization; diagnostic imaging; emulsion; hemangioma; liver tumor; male; procedures; therapy |
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Springer |
18657257 |
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38526803 |
Article |
Q3 |
302 |
15057 |
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9 |
Fedrizal F.F.; Wijaya I.P.; Abdullah M.; Yamin M. |
Fedrizal, Fenandri Fadillah (57219280233); Wijaya, Ika Prasetya (57193731572); Abdullah, Murdani (7103393434); Yamin, Muhammad (23475706300) |
57219280233; 57193731572; 7103393434; 23475706300 |
Elevated neutrophyl-to-lymphocyte ratioand smoking are associated with chronic total occlusion in patients with ST elevation myocardial infarction |
2024 |
BMC Cardiovascular Disorders |
24 |
1 |
12 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85181244917&doi=10.1186%2fs12872-023-03680-3&partnerID=40&md5=9aaf3c2915cdc2583c57f09d4d1e5b80 |
Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Unit Epidemiology, Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Fedrizal F.F., Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Wijaya I.P., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Abdullah M., Unit Epidemiology, Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Yamin M., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Background: Atherosclerosis is a progressive disease characterized by the build-up of lipids and connective tissue in the large arteries. Some patients experience chronic total occlusion (CTO). Inflammation plays a key role in the development and complications of atherosclerosis. Neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation associated with the development of acute coronary syndrome (ACS). We aimed to assess the relationship between NLR and CTO in ACS patients with ST elevated myocardial infarction (STEMI) in Indonesia. Methods: This cross-sectional study was performed with secondary data obtained from patient medical records at Cipto Mangunkusumo National Central Hospital, Jakarta. Inclusion criteria were patients with ACS and STEMI who underwent coronary angiography in 2015–2018. Results: A total of 98 patients were enrolled in the analysis. Most subjects with CTO were male, elderly (> 60), smoking, had no history of diabetes mellitus (DM) or hypertension, no family history of coronary heart disease (CHD), but had a history of ACS and had never consumed statin or antiplatelet medications. Bivariate logistic regression analysis revealed that male gender (PR = 1.820; 95%CI 0.871–3.805; p = 0.025) and smoking (PR = 1.781; 95%CI 1.028–3.086; p = 0.004) were significantly correlated with CTO. Receiver operator characteristic (ROC) curve revealed that higher NLR (≥ 6.42) could predict a CTO diagnosis with positive predictive value (PPV) of 91%. Multivariate analysis revealed that NLR was correlated with an 11.2-fold increase in occurrence of CTO (95%CI 3.250-38.303; p < 0.001). Additionally, smoking was correlated with a 7-fold increase in CTO (95% CI 1.791–30.508; p = 0.006). Conclusion: NLR value of ≥ 6.42 is potentially useful as a marker of CTO in STEMI patients. In addition, smoking increases the risk of CTO in ACS/STEMI patients. © 2023, The Author(s). |
Chronic total occlusion; Coronary angiography; Coronary artery Disease; Myocardial Infarction; Neutrophil-to-lymphocyte ratio |
Acute Coronary Syndrome; Aged; Atherosclerosis; Chronic Disease; Coronary Occlusion; Cross-Sectional Studies; Female; Humans; Inflammation; Lymphocytes; Male; Percutaneous Coronary Intervention; Smoking; ST Elevation Myocardial Infarction; Treatment Outcome; antithrombocytic agent; hydroxymethylglutaryl coenzyme A reductase inhibitor; acute coronary syndrome; adult; age; aged; Article; bivariate analysis; cardiovascular risk; chronic total occlusion; controlled study; coronary angiography; cross-sectional study; diabetes mellitus; diagnostic test accuracy study; disease association; female; human; hypertension; Indonesia; ischemic heart disease; logistic regression analysis; major clinical study; male; medical record; multivariate analysis; neutrophil lymphocyte ratio; predictive value; re |
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BioMed Central Ltd |
14712261 |
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38172732 |
Article |
Q2 |
601 |
8561 |
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10 |
Amalia M.; Saputri F.C.; Sauriasari R.; Widyantoro B. |
Amalia, Muttia (57201697619); Saputri, Fadlina Chany (45561842900); Sauriasari, Rani (16246507200); Widyantoro, Bambang (35286148600) |
57201697619; 45561842900; 16246507200; 35286148600 |
Cholesterol low density lipoprotein associations with complete blood count parameters in atherosclerotic cardiovascular disease patients |
2024 |
AIP Conference Proceedings |
3155 |
1 |
030007 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85196498049&doi=10.1063%2f5.0218103&partnerID=40&md5=d5db89cbf03fdeda55e3adcd862fe364 |
Doctoral Program, Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Department of Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - National Cardiovascular Center, Harapan Kita, Jakarta, 11420, Indonesia |
Amalia M., Doctoral Program, Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Saputri F.C., Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Sauriasari R., Department of Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Widyantoro B., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - National Cardiovascular Center, Harapan Kita, Jakarta, 11420, Indonesia |
Cholesterol low density lipoprotein (LDL) is strongly associated with the development of atherosclerotic vascular disease (ASCVD). The objective of this study is to assess the relationships between cholesterol LDL and complete blood count (CBC) in ASCVD patients. This cross-sectional study was conducted at the National Cardiovascular Center Harapan Kita Jakarta. A total of 75 ASCVD patients from outpatient and emergency room departments were included in this study. The Chi-square test and the regression logistic analysis test were used to assess the relationships between cholesterol LDL and CBC. In this study, LDL level was found to be associated with the levels of leucocyte, percentage of eosinophil, percentage of lymphocyte, and absolute monocyte level. Lower eosinophil and lymphocyte levels were associated with increased LDL level. Regression logistic analysis revealed that the percentage of eosinophil (95%CI, 1.20 - 8.98; p value=0.02) and absolute monocyte (95%CI, 0.11 - 0.97; p value=0.04) were significant predictors of higher LDL levels in ASCVD. Increased inflammation due to elevated LDL may have resulted in circulating blood count alterations. Leucocytes and their differential count may aid in determining chronic inflammation and the progression of ASCVD. © 2024 Author(s). |
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American Institute of Physics |
0094243X |
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Conference paper |
- |
164 |
21059 |
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11 |
Sekarsari D.; Handoyono Q.F.; Amal M.Y.; Maharani M.A.P.; Hendriarto A. |
Sekarsari, Damayanti (57193342279); Handoyono, Quinta Febryani (58993286100); Amal, Mohamad Yanuar (57221702104); Maharani, Maria Angela Putri (58158818200); Hendriarto, Andra (57216821517) |
57193342279; 58993286100; 57221702104; 58158818200; 57216821517 |
Pediatric paraparesis: Radiological challenges in multidrug-resistant tuberculous spondylitis based on experience in Indonesia |
2024 |
Radiology Case Reports |
19 |
8 |
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3287 |
3293 |
6 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85193445919&doi=10.1016%2fj.radcr.2024.04.001&partnerID=40&md5=71f94f873b95af48e9249b2aeb5dc7ea |
Division of Pediatric Radiology, Department of Radiology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Department of Radiology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Department of Anatomic Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Department of Orthopedics and Traumatology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia |
Sekarsari D., Division of Pediatric Radiology, Department of Radiology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Handoyono Q.F., Department of Radiology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Amal M.Y., Division of Pediatric Radiology, Department of Radiology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Maharani M.A.P., Department of Anatomic Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Hendriarto A., Department of Orthopedics and Traumatology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia |
Multidrug-resistant tuberculous spondylitis is a global health issue, especially in developing nations, and non-specific symptoms lead to delay in identification, treatment, and potential disability in children. Radiology plays a crucial role in diagnosing tuberculous spondylitis, which in turn might lead to effective treatment, prevention of disability and improved patient outcomes. Our case involved a 20-month-old malnourished child presented with paraparesis, revealing a history of contact with parental multidrug-resistant tuberculosis. Multimodality radiological examinations, including conventional radiography, CT, and MRI revealed extensive disease of the spine with disc involvement, large paravertebral abscess, and kyphotic deformity which produced neurological deficits, necessitating both anti-tuberculosis regimen and surgical intervention. Radiological examinations have a pivotal role in diagnosing, evaluating and guiding timely management of multidrug-resistant tuberculous spondylitis. Prompt diagnosis of the condition is crucial in order to prevent potentially severe complications, which contribute significantly to morbidity. Our case demonstrated the importance of radiology in diagnosing extensive spine involvement of the disease causing neurological deficits. Furthermore, radiology also helps in managing tuberculous spondylitis to prevent future disability in a child patient of a developing country. This case highlights the crucial significance of radiological imaging in the diagnosis and management of pediatric tuberculous spondylitis in impoverished nations. The patient's complex medical history highlights the socioeconomic factors contributing to tuberculosis burden. Early and comprehensive radiological assessment, together with collaboration between radiologists and clinicians, is vital for timely intervention and improved outcomes in pediatric tuberculous spondylitis cases to prevent the impact of this debilitating disease on children. © 2024 |
Pediatric imaging; Tuberculosis; Tuberculous spondylitis |
abscess; Article; Babinski reflex; case report; child; clinical article; computer assisted tomography; erythrocyte sedimentation rate; female; gait; ground glass opacity; human; Indonesia; kyphosis; lung consolidation; lung fibrosis; malnutrition; multidrug resistant tuberculosis; muscle strength; neurologic examination; nuclear magnetic resonance imaging; paraplegia; physical examination; preschool child; radiodiagnosis; radiological parameters; tuberculous spondylitis |
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Elsevier Inc. |
19300433 |
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Article |
Q4 |
226 |
17897 |
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13 |
Lubis S.M.; Soesanti F.; Hidayati E.L.; Aap B.T. |
Lubis, Siska Mayasari (57199647517); Soesanti, Frida (37068080600); Hidayati, Eka Laksmi (57200542624); Aap, Bambang Tridjaja (59173556500) |
57199647517; 37068080600; 57200542624; 59173556500 |
Congenital Adrenal Hyperplasia in Children: The Relationship between Plasma Renin Activity and Hypertension |
2024 |
Iranian Journal of Medical Sciences |
49 |
6 |
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377 |
383 |
6 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85196070765&doi=10.30476%2fijms.2023.98508.3058&partnerID=40&md5=91547d4afbbefb5cfac5f020cbce3da4 |
Department of Child Health, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Department of Child Health, Faculty of Medicine, Universitas Indonesia Jakarta, Indonesia |
Lubis S.M., Department of Child Health, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Soesanti F., Department of Child Health, Faculty of Medicine, Universitas Indonesia Jakarta, Indonesia; Hidayati E.L., Department of Child Health, Faculty of Medicine, Universitas Indonesia Jakarta, Indonesia; Aap B.T., Department of Child Health, Faculty of Medicine, Universitas Indonesia Jakarta, Indonesia |
Background: Children with Congenital Adrenal Hyperplasia (CAH) have a higher chance of hypertension. The likelihood of hypertension is higher in CAH children who get fludrocortisone medication and have an over-suppression. Plasma renin activity (PRA) is a sensitive indicator when the fludrocortisone dose is insufficient. The objective of this study is to assess the relationship between plasma renin activity with hypertension in 21-hydroxylase-deficient (21-OHD) CAH children. Methods: This cross-sectional observational analytical study was conducted in 2019 at the Pediatric Endocrinology Outpatient Clinic in Dr. Cipto Mangunkusumo Hospital (RSCM), Jakarta, Indonesia. The subjects were 21-OHD CAH children, aged >6 months to 18 years who had already taken hydrocortisone with or without fludrocortisone for at least 6 months, and were divided into hypertension and non-hypertension groups. The subjects were selected by a consecutive sampling method. Data was analyzed using SPSS software (version 23.0) with unpaired t test analysis and multiple logistic regression test. Statistical significance was achieved if P<0.05. Results: Forty 21-OHD CAH patients were included, and 20 subjects (50%) had hypertension. A higher incidence of hypertension was found in salt-wasting CAH than in simple virilizing types (59.3% vs 30.8%). There was a significant mean difference in PRA levels between hypertension and non-hypertension groups in salt-wasting patients (P=0.016). A significant difference between the last dose of hydrocortisone with the number of hypertension patients in saltwasting patients (P=0.032) was found, and low PRA levels showed a 1.09 times higher risk of hypertension. Conclusion: Children with salt-wasting CAH with low PRA levels had a higher risk of getting hypertension. © Iranian Journal of Medical Sciences. |
Adrenal hyperplasia; congenital; Hydrocortisone; Hypertension |
fludrocortisone; hydrocortisone; renin; age distribution; analytic method; Article; body mass; child; clinical article; clinical evaluation; controlled study; cross-sectional study; drug dose regimen; female; high risk population; human; hypertension; incidence; Indonesia; male; observational study; outpatient department; patient selection; plasma renin activity; salt wasting; school child; steroid 21 monooxygenase deficiency; treatment duration |
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Shiraz University of Medical Sciences |
02530716 |
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Article |
Q2 |
413 |
12184 |
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16 |
Prawiroharjo P.; Anggraini H.; Geraldi I.P.; Octaviana F.; Budikayanti A.; Safri A.Y.; Wiratman W.; Indrawati L.A.; Fadli N.; Harsono A.R.; Hakim M. |
Prawiroharjo, Pukovisa (57195838668); Anggraini, Hikma (59124155100); Geraldi, Iskandar Purba (58116732300); Octaviana, Fitri (26029958700); Budikayanti, Astri (57194713932); Safri, Ahmad Yanuar (57091699300); Wiratman, Winnugroho (57191920526); Indrawati, Luh Ari (57205117182); Fadli, Nurul (58772486600); Harsono, Adrian Ridski (59011489600); Hakim, Manfaluthy (57216861859) |
57195838668; 59124155100; 58116732300; 26029958700; 57194713932; 57091699300; 57191920526; 57205117182; 58772486600; 59011489600; 57216861859 |
Factors correlating to decisions for prescribing pharmacological treatment and referrals in suspected peripheral neuropathy cases in chat consultation-based application |
2024 |
Heliyon |
10 |
10 |
e30713 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85192934441&doi=10.1016%2fj.heliyon.2024.e30713&partnerID=40&md5=8df51869c2fab92bbe63df29c1ff5e0a |
Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia; Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia; Department of Neurology, Universitas Indonesia Hospital, Indonesia |
Prawiroharjo P., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia, Department of Neurology, Universitas Indonesia Hospital, Indonesia; Anggraini H., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia; Geraldi I.P., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia; Octaviana F., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia; Budikayanti A., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia; Safri A.Y., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia; Wiratman W., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia, Department of Neurology, Universitas Indonesia Hospital, Indonesia; Indrawati L.A., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia; Fadli N., Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia, Department of Neurology, Universitas Indonesia Hospital, Indonesia; Harsono A.R., Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia, Department of Neurology, Universitas Indonesia Hospital, Indonesia; Hakim M., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia |
Introduction: Since the COVID-19 pandemic, there has been increasing use ofchat-based telemedicine, including for patients with neuropathy complaints. It is imperative to learn how to effectively use telemedicine. This study describes the characteristics of patients with neuropathy complaints in chat-based telemedicine services in Indonesia and their influence on treatment decisions and referrals. Methods: This is a retrospective cross-sectional study during the COVID-19 pandemic era (March 2020 to December 2021) using anonymous secondary data from patient chat databases on Indonesian application-based telemedicine services (Halodoc, Alodokter, Good Doctor, and Milvik). We applied bivariate and multivariate analysis. Results: We obtained 1051 patients with suspected peripheral nerve complaints (4 per 10,000) from a total of 2,199,527 user consultations, with the majority being 40–64 years old females and diabetes mellitus was the leading comorbid (90.7%). Most patients received treatment (90.7%) and only 11.4% patients were referred. Multivariate analysis showed that treatment was more likely to be given by a neurologist (p < 0.01). Chronic symptoms (p < 0.01) and previous laboratory/other tests (p = 0.01) decreased the likelihood of medication prescription. Referrals were more likely to be given to chronic onset (p = 0.02), hypertension and heart disease (p < 0.01), and previous laboratory/other tests (p = 0.02). The opposite was true for age≥65 years, female (p = 0.04), and neurologists or other specialists as responders (p < 0.01). Conclusion: We identified several factors that influence the treatment decision such as female patients and onset. Meanwhile, age, sex, chronic symptoms, history of hypertension and heart disease, and previous laboratory/other tests may influence the referral decisions. General practitioners were more likely to refer the patients whereas neurologists or other specialists were more likely to give treatment. Chat-based telemedicine services can still be developed in the future to be better. © 2024 |
Chat; Clinical decision making; Neuropathic pain; Neuropathy complaints; Paresthesia; Telemedicine |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
609 |
8422 |
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22 |
Sunardi D.; Chandra D.N.; Medise B.E.; Manikam N.R.M.; Friska D.; Lestari W.; Insani P.N.C. |
Sunardi, Diana (57192075078); Chandra, Dian Novita (57190861000); Medise, Bernie Endyarni (57226215370); Manikam, Nurul Ratna Mutu (56681219300); Friska, Dewi (57202805330); Lestari, Wiji (57222081857); Insani, Putri Novia Choiri (57565215500) |
57192075078; 57190861000; 57226215370; 56681219300; 57202805330; 57222081857; 57565215500 |
Health effects of alkaline, oxygenated, and demineralized water compared to mineral water among healthy population: A systematic review |
2024 |
Reviews on Environmental Health |
39 |
2 |
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339 |
349 |
10 |
1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85145691207&doi=10.1515%2freveh-2022-0057&partnerID=40&md5=692a386f05aa8e9a2b0f8e4a89233b9b |
Indonesian Hydration Working Group, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Child Health Department, Faculty of Medicine Universitas Indonesia, Dr.Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Occupational Medicine, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Sunardi D., Indonesian Hydration Working Group, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Chandra D.N., Indonesian Hydration Working Group, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Medise B.E., Indonesian Hydration Working Group, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Child Health Department, Faculty of Medicine Universitas Indonesia, Dr.Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Manikam N.R.M., Indonesian Hydration Working Group, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Friska D., Indonesian Hydration Working Group, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Occupational Medicine, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Lestari W., Indonesian Hydration Working Group, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Insani P.N.C., Indonesian Hydration Working Group, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Objectives: There are many water types available on the market. They are widely known in public with health claims. The questions are, are those claims are scientifically proven or those are just testimonies from the consumers or overclaimed by the producers. This study aims to systematically review evidences on the health effects of alkaline, oxygenated, and demineralized water in comparison with mineral water among healthy population. Contents: Data were obtained from databases PubMed, Cochrane, Scopus, EBSCO, dan Science Direct since January 2000 until July 2022. There were 10 eligible articles, consisted of two articles on alkaline, four articles on oxygenated, and four articles on demineralized water, that furtherly being analyzed. Summary: Compared to consumption of mineral water, consumption of alkaline and oxygenated water did not show any significant difference on gut microbiota, urine pH, blood parameter, or fitness parameter. While, consumption of demineralized water in the long term resulted in lower quality of certain nutrient intake. Outlook: Recent evidences do not prove any additional health effects of alkaline, oxygenated, or demineralized water compared to mineral water. In contrast, demineralized water consumption in the long run was proven to lead to adverse effect. © 2022 the author(s), published by De Gruyter, Berlin/Boston. |
alkaline water; demineralized water; health benefit; mineral water; oxygenated water |
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Walter de Gruyter GmbH |
00487554 |
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36571558 |
Review |
Q1 |
897 |
5023 |
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23 |
Lazarus G.; Putra I.G.N.S.; Junaidi M.C.; Oswari J.S.; Oswari H. |
Lazarus, Glen (57927339800); Putra, I Gusti Ngurah Sanjaya (57217596461); Junaidi, Michelle Clarissa (57974344300); Oswari, Jessica Sylvania (58891104500); Oswari, Hanifah (12777323800) |
57927339800; 57217596461; 57974344300; 58891104500; 12777323800 |
The relationship of vitamin D deficiency and childhood diarrhea: a systematic review and meta-analysis |
2024 |
BMC Pediatrics |
24 |
1 |
125 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85185277894&doi=10.1186%2fs12887-024-04599-0&partnerID=40&md5=85b6f5889cf8440100e00f5e95243139 |
Department of Child Health, Gastrohepatology Division, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Child Health, Gastroenterology and Hepatology Division, Medical School, Universitas Udayana, Bali, Indonesia |
Lazarus G., Department of Child Health, Gastrohepatology Division, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Putra I.G.N.S., Department of Child Health, Gastroenterology and Hepatology Division, Medical School, Universitas Udayana, Bali, Indonesia; Junaidi M.C., Department of Child Health, Gastrohepatology Division, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Oswari J.S., Department of Child Health, Gastrohepatology Division, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Oswari H., Department of Child Health, Gastrohepatology Division, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Introduction: Vitamin D deficiency may increase the risk of childhood diarrhea. We aim to carry out a review and meta-analysis of the evidence relating vitamin D insufficiency to childhood diarrhea. Methods: We searched PubMed, Ovid, Scopus, and Cochrane Library (from inception to August 2022), then independently reviewed the eligibility, and read full-text reviews for selected articles. Keywords used were ‘vitamin D’, ’25-hydroxyvitamin D’, ‘vitamin D deficiency’, ‘diarrhea’, ‘gastroenteritis’, ‘children’, and ‘pediatric’. The search was limited to studies only in English and with available full-text. Year limitation was not applied in our search. Unpublished trials, dissertations, preliminary reports, conference abstracts, and repositories were excluded from the study. Newcastle-Ottawa Scale was used as the risk of bias assessment tool. Meta-analysis using the random-effects model was done. Results: Out of 5,565 articles, 12 articles were included in our systematic review, however only 7 articles were eligible for meta-analysis. Meta-analysis showed a statistically significant association between vitamin D deficiency and diarrhea in children in developing countries (OR = 1.79; 95% CI = 1.15 to 2.80; p = 0.01). On the secondary outcome, the association of vitamin D deficiency and duration or recurrences of diarrhea are conflicting. Conclusions: There is an association between vitamin D deficiency and the prevalence of diarrhea. Future studies should evaluate the causal association, the impact of vitamin D deficiency on the severity of diarrhea, and whether vitamin D deficiency treatments affects the prevalence of diarrhea. © The Author(s) 2024. |
Childhood diarrhea; Pediatric; Vitamin D deficiency |
Child; Diarrhea; Gastroenteritis; Humans; Prevalence; Vitamin D; Vitamin D Deficiency; Vitamins; 25 hydroxyvitamin D; vitamin D; vitamin; vitamin D; age distribution; Article; chemiluminescence immunoassay; diarrhea; disease association; disease duration; disease severity; enzyme linked immunosorbent assay; evidence based medicine; gastroenteritis; human; meta analysis; Newcastle-Ottawa scale; outcome assessment; pediatric patient; prevalence; recurrence risk; systematic review; vitamin blood level; vitamin D deficiency; child; complication; diarrhea; gastroenteritis; vitamin D deficiency |
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BioMed Central Ltd |
14712431 |
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38365626 |
Article |
Q1 |
742 |
6590 |
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