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Syahrani L.; Asih P.B.S.; Bowolaksono A.; Dwiranti A.; Zubaidah S.; Rozi I.E.; Permana D.H.; Bøgh C.; Bangs M.J.; Grieco J.P.; Achee N.L.; Lobo N.F.; Syafruddin D. |
Syahrani, Lepa (55014440600); Asih, Puji B. S. (6507080729); Bowolaksono, Anom (57205093224); Dwiranti, Astari (55151437900); Zubaidah, Siti (57216572364); Rozi, Ismail E. (57193863994); Permana, Dendi H. (57218188245); Bøgh, Claus (6602120205); Bangs, Michael J. (7007079698); Grieco, John P. (7003422533); Achee, Nicole L. (6603480149); Lobo, Neil F. (35392948100); Syafruddin, Din (6602774565) |
55014440600; 6507080729; 57205093224; 55151437900; 57216572364; 57193863994; 57218188245; 6602120205; 7007079698; 7003422533; 6603480149; 35392948100; 6602774565 |
Impact of a spatial repellent intervention on Anopheles kdr insecticide resistance allele in Sumba, Indonesia |
2024 |
Malaria Journal |
23 |
1 |
31 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85182828683&doi=10.1186%2fs12936-024-04841-1&partnerID=40&md5=d012e123af603ec236833d76ef429e7e |
Doctoral Program, Department of Biology, Faculty of Mathematics and Natural Sciences, University of Indonesia, Depok, Indonesia; Eijkman Research Center for Molecular Biology, National Research and Innovation Agency (BRIN), Cibinong, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, University of Indonesia, Depok, Indonesia; Doctoral Program, Faculty of Medicine, University of Hasanuddin, Makassar, Indonesia; Doctoral Program of Biomedical Sciences, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; The Sumba Foundation, Public Health and Malaria Control, Sumba, Indonesia; Public Health and Malaria Control, PT Freeport Indonesia, International SOS, Mimika, Indonesia; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, IN, United States; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Hasanuddin University Medical Research Center (HUMRC), Makassar, Indonesia |
Syahrani L., Doctoral Program, Department of Biology, Faculty of Mathematics and Natural Sciences, University of Indonesia, Depok, Indonesia, Eijkman Research Center for Molecular Biology, National Research and Innovation Agency (BRIN), Cibinong, Indonesia; Asih P.B.S., Eijkman Research Center for Molecular Biology, National Research and Innovation Agency (BRIN), Cibinong, Indonesia; Bowolaksono A., Department of Biology, Faculty of Mathematics and Natural Sciences, University of Indonesia, Depok, Indonesia; Dwiranti A., Department of Biology, Faculty of Mathematics and Natural Sciences, University of Indonesia, Depok, Indonesia; Zubaidah S., Eijkman Research Center for Molecular Biology, National Research and Innovation Agency (BRIN), Cibinong, Indonesia; Rozi I.E., Eijkman Research Center for Molecular Biology, National Research and Innovation Agency (BRIN), Cibinong, Indonesia, Doctoral Program, Faculty of Medicine, University of Hasanuddin, Makassar, Indonesia; Permana D.H., Eijkman Research Center for Molecular Biology, National Research and Innovation Agency (BRIN), Cibinong, Indonesia, Doctoral Program of Biomedical Sciences, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Bøgh C., The Sumba Foundation, Public Health and Malaria Control, Sumba, Indonesia; Bangs M.J., Public Health and Malaria Control, PT Freeport Indonesia, International SOS, Mimika, Indonesia; Grieco J.P., Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, IN, United States; Achee N.L., Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, IN, United States; Lobo N.F., Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, IN, United States; Syafruddin D., Eijkman Research Center for Molecular Biology, National Research and Innovation Agency (BRIN), Cibinong, Indonesia, Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia, Hasanuddin University Medical Research Center (HUMRC), Makassar, Indonesia |
Background: The emergence of insecticide resistance and outdoor transmission in malaria-endemic areas underlines the urgent need to develop innovative tools, such as spatial repellents (SR), that may circumvent this residual transmission. With limited options for effective insecticides, regular resistance monitoring is warranted for selecting and using appropriate tools. This study evaluates the pyrethroid knockdown resistance (kdr) allele before and after implementing a transfluthrin-based spatial repellent (SR) intervention in placebo-treated clusters. Methods: This study looks at the frequency distribution of the kdr allele in Sumba Island from June 2015 to August 2018. Insecticide susceptibility tests were carried out on female Anopheles sp. aged 3–5 days against permethrin 21.5 μg/ml, deltamethrin 12.5 μg/ml, and transfluthrin 10 μg/ml using CDC bottle assay. PCR sequencing of representative samples from adult mosquito collections and insecticide tests revealed the presence of kdr mutations (L1014F and L1014S) in the VGSC gene. Results: A total of 12 Anopheles species, Anopheles tesselatus, Anopheles. aconitus, Anopheles barbirostris, Anopheles kochi, Anopheles annularis, Anopheles maculatus, Anopheles sundaicus, Anopheles flavirostris, Anopheles balabacensis, Anopheles indefinitus, Anopheles subpictus, and Anopheles vagus were analysed. Anopheles vagus and An. sundaicus predominated in the larval populations. Susceptibility assays for all insecticides identified fully susceptible phenotypes in all species examined. Anopheles increasing frequency of kdr mutant alleles during the 3 year SR deployment was observed in both SR-treated and placebo areas, a statistically significant increase occurred in each arm. However, it is unclear how significant SR is in causing the increase in mutant alleles. The L1014S, knockdown resistance east type (kdr-e) allele was detected for the first time among the mosquito samples in this study. The L1014F, knockdown resistance west type (kdr-w) allele and heteroduplex form (wild-type—mutant) were found in almost all Anopheles species examined, including An. vagus, An. aconitus, An. subpictus, An. tesselatus, An. annularis, An. flavirostris and An. sundaicus. Conclusion: The presence of fully susceptible phenotypes over time, along with an increase in the frequency distribution of the L1014F/S mutations post-intervention, suggest drivers of resistance external to the study, including pyrethroid use in agriculture and long-lasting insecticidal nets (LLINs). However, this does not negate possible SR impacts that support resistance. More studies that enable the comprehension of possible SR-based drivers of resistance in mosquitoes need to be conducted. © 2024, The Author(s). |
Kdr; L1014F; L1014S; Pyrethroid; Resistance; VGSC |
Alleles; Animals; Anopheles; Cyclopropanes; Female; Fluorobenzenes; Indonesia; Insecticide Resistance; Insecticides; Permethrin; deltamethrin; insect repellent; permethrin; placebo; transfluthrin; unclassified drug; cyclopropane derivative; fluorobenzene; insecticide; transfluthrin; allele; Anopheles; Anopheles annularis; Anopheles balabacensis; Anopheles barbirostris; Anopheles flavirostris; Anopheles indefinitus; Anopheles kochi; Anopheles maculatus; Anopheles subpictus; Anopheles sundaicus; Anopheles tesselatus; Anopheles vagus; Anopheles. aconitus; Article; controlled study; gene; gene frequency; gene knockdown; gene mutation; genetic susceptibility; Indonesia; insecticide resistance; kdr gene; nonhuman; phenotype; polymerase chain reaction; spatial analysis; allele; animal; female; ge |
District health departments of Southwest and West Sumba; East Nusa Tenggara Province; Eijkman Research Center for Molecular Biology; Government of Indonesia National Research and Innovation Agency; Health Research Organization; Bill and Melinda Gates Foundation, BMGF; University of Notre Dame, ND, (OPP1081737); Badan Riset dan Inovasi Nasional, BRIN; Universitas Hasanuddin; Ministry of Health of the Republic of Indonesia |
Funding text 1: The authors are grateful for the support of the Eijkman Research Center for Molecular Biology, National Research and Innovation Agency (BRIN), Cibinong, Indonesia; The University of Hasanuddin, Makassar, Indonesia; the Ministry of Health Republic of Indonesia; District health departments of Southwest and West Sumba, and East Nusa Tenggara Province. We appreciate the contribution of |
BioMed Central Ltd |
14752875 |
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38254131 |
Article |
Q1 |
1237 |
2935 |
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4 |
Rahayu D.; Meutia A.P.; Priyatini T.; Suratih N.M.D.; Maidarti M.; Harzif A.K.; Muharam R.; Pratama G. |
Rahayu, Deniswari (57208300474); Meutia, Alfa Putri (57203368133); Priyatini, Tyas (57192265423); Suratih, Ni Made Desy (26634582200); Maidarti, Mila (56320510400); Harzif, Achmad Kemal (57191493435); Muharam, R. (57191492732); Pratama, Gita (58162878900) |
57208300474; 57203368133; 57192265423; 26634582200; 56320510400; 57191493435; 57191492732; 58162878900 |
Association of hirsutism and anthropometric profiles with sexual dysfunction and anxiety levels in infertile Indonesian women with polycystic ovarian syndrome |
2024 |
Middle East Fertility Society Journal |
29 |
1 |
19 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85189636536&doi=10.1186%2fs43043-024-00178-6&partnerID=40&md5=22df206c1e005692cbf08891765f633a |
Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Urogynecology and Reconstructive Pelvic Surgery Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Reproductive Endocrinology Division, Department of Obstetrics and Gynecology, Persahabatan General Hospital, Jakarta, Indonesia; Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Yasmin IVF Clinic Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Rahayu D., Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Meutia A.P., Urogynecology and Reconstructive Pelvic Surgery Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Priyatini T., Urogynecology and Reconstructive Pelvic Surgery Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Suratih N.M.D., Reproductive Endocrinology Division, Department of Obstetrics and Gynecology, Persahabatan General Hospital, Jakarta, Indonesia; Maidarti M., Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Yasmin IVF Clinic Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Harzif A.K., Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Yasmin IVF Clinic Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Muharam R., Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Yasmin IVF Clinic Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Pratama G., Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Yasmin IVF Clinic Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Background: Hyperandrogenism is frequently found in polycystic ovary syndrome (PCOS) and contributes to physical manifestations like hirsutism and obesity, along with infertility. This condition can result in anxiety, depression, and body image disorders, potentially leading to sexual dysfunction. The objective of this investigation was to assess the correlation among hirsutism, anthropometric characteristics, sexual dysfunction, and anxiety levels among infertile Indonesian women diagnosed with PCOS. Methods: From December 2021 to December 2022, a cross-sectional study was undertaken involving 71 infertile women diagnosed with PCOS at Yasmin Clinic, Dr. Cipto Mangunkusumo General Hospital in Jakarta, Indonesia. Hirsutism was assessed using the modified Ferriman-Gallwey (mFG) score; the anthropometric profile was assessed using BMI and waist-to-hip ratio. The assessment of sexual dysfunction was conducted using the Female Sexual Function Index (FSFI) questionnaire, while the evaluation of anxiety levels utilized the HAM-A questionnaires. Results: In this study, it was discovered that 53.3% of subjects experienced sexual dysfunction. However, there was no statistically significant relationship between hirsutism, anthropometric profile, and sexual dysfunction score in infertile women with PCOS (p > 0.05). Analysis of the overall FSFI domain score revealed that lubrication and satisfaction were lower in obese patients (p = 0.02 and p = 0.03), but this did not contribute to an overall sexual dysfunction score. Also, we found that subjects who experienced sexual dysfunction had a higher anxiety score (p < 0.005), with correlation analysis showing that Ferriman-Gallwey (FG) scores have a significant positive correlation with anxiety. Conclusion: There is no correlation between hirsutism, anthropometric profile, and sexual dysfunction in infertile Indonesian women diagnosed with PCOS. However, hirsutism could play a role in causing anxiety in Indonesian PCOS women. Additional investigation is required, as female sexual function is an intricate subject. © The Author(s) 2024. |
Anthropometric profile; Hyperandrogenism; Infertility; PCOS; Polycystic ovarian syndrome; Sexual dysfunction |
contraceptive agent; follitropin; luteinizing hormone; adult; anthropometric parameters; anxiety disorder; arousal; Article; automation; body height; body mass; body weight; correlational study; cross-sectional study; dyspareunia; educational status; employee; employment status; female; female infertility; Female Sexual Function Index; Hamilton Anxiety Scale; hip circumference; hirsutism; human; hyperandrogenism; Indonesian; intra-abdominal fat; laboratory test; lubrication; major clinical study; modified ferriman gallwey score; obese patient; obesity; orgasm; ovary polycystic disease; patient satisfaction; pleasure; prevalence; questionnaire; sexual dysfunction; sexual function; skin disease assessment; social status; subcutaneous fat; transvaginal echography; unemployment; waist circumfe |
Indonesian Reproductive Medicine Research and Training Center; INAREPROMED; PUTI Saintekes 2020, (NKB-2278/UN.2) |
Funding text 1: The authors express gratitude to the Indonesian Reproductive Medicine Research and Training Center (INAREPROMED) and the teams at Yasmin Clinic and Rumah Sakit Dr. Cipto Mangunkusumo Hospital for their invaluable assistance and support throughout this study.; Funding text 2: This study received funding from the PUTI Saintekes 2020 grant, contract number NKB-2278/UN.2.RST/HKP.05.00. |
Springer Science and Business Media Deutschland GmbH |
11105690 |
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Article |
Q3 |
322 |
14459 |
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5 |
Agung F.H.; Sekartini R.; Sudarsono N.C.; Hendarto A.; Werdhani R.A.; Pudjiati S.R.; Hanum L.; Naufal A.; Sawyer S.M. |
Agung, Fransisca Handy (36488930100); Sekartini, Rini (50162572300); Sudarsono, Nani Cahyani (57201862518); Hendarto, Aryono (57204142249); Werdhani, Retno Asti (57189088848); Pudjiati, Sri Retno (58909932500); Hanum, Lathifah (55606285800); Naufal, Affan (58766280400); Sawyer, Susan M (7103253172) |
36488930100; 50162572300; 57201862518; 57204142249; 57189088848; 58909932500; 55606285800; 58766280400; 7103253172 |
Development and validation of the adolescent behavioural change Counselling Assessment Tool in Indonesia |
2024 |
BMC Health Services Research |
24 |
1 |
257 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85186205298&doi=10.1186%2fs12913-024-10582-3&partnerID=40&md5=a579a3309c366dc68cb6f5c74e72efe3 |
Faculty of Medicine, Universitas Pelita Harapan, Jl. Jend. Sudirman No.20, Bencongan, Kelapa Dua, Tangerang, Banten, 15810, Indonesia; Department of Child Health, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jl. Salemba Raya No.6 Jakarta Pusat, Jakarta, 10430, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6 Jakarta Pusat, Jakarta, 10430, Indonesia; Faculty of Psychology, Universitas Indonesia, Kampus UI, West Java, Depok, Indonesia; Balaraja Distric Hospital, Jl. Rumah Sakit No 88, Balaraja, Tangerang, Banten, Indonesia; Centre for Adolescent Health, Royal Children’s Hospital and Murdoch Children’s Research Institute, Department of Paediatrics, The University of Melbourne, 50 Flemington Rd, Parkville, 3052, VIC, Australia |
Agung F.H., Faculty of Medicine, Universitas Pelita Harapan, Jl. Jend. Sudirman No.20, Bencongan, Kelapa Dua, Tangerang, Banten, 15810, Indonesia; Sekartini R., Department of Child Health, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jl. Salemba Raya No.6 Jakarta Pusat, Jakarta, 10430, Indonesia; Sudarsono N.C., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6 Jakarta Pusat, Jakarta, 10430, Indonesia; Hendarto A., Department of Child Health, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jl. Salemba Raya No.6 Jakarta Pusat, Jakarta, 10430, Indonesia; Werdhani R.A., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6 Jakarta Pusat, Jakarta, 10430, Indonesia; Pudjiati S.R., Faculty of Psychology, Universitas Indonesia, Kampus UI, West Java, Depok, Indonesia; Hanum L., Faculty of Psychology, Universitas Indonesia, Kampus UI, West Java, Depok, Indonesia; Naufal A., Balaraja Distric Hospital, Jl. Rumah Sakit No 88, Balaraja, Tangerang, Banten, Indonesia; Sawyer S.M., Centre for Adolescent Health, Royal Children’s Hospital and Murdoch Children’s Research Institute, Department of Paediatrics, The University of Melbourne, 50 Flemington Rd, Parkville, 3052, VIC, Australia |
Background: Primary care provides an important context to engage adolescents and their families in healthy lifestyles with the goal of reducing future behaviour-related health problems. Developing a valid tool to assess health professionals’ skills in behavioural change counselling is integral to improving the quality of clinical care provided to adolescents in Indonesia. Methods: This work was nested within a project to develop a training program to enhance the behaviour-change counselling of adolescents and their parents by Indonesian primary care professionals. Initial item development was based on the content of the training module and the domain structure of the Behavioral Change Counselling Index (BECCI), a commonly used tool to assess counselling quality in healthcare settings. Expert panels were used to test content validity, while face validity was assessed by a group of trained psychologists. Inter-rater agreement was calculated prior to tests of construct validity and reliability, which involved psychologists rating 125 audio-taped counselling sessions between the health professional and adolescent patients, together with a parent. Results: An initial 13-item tool was developed using a 1–5 Likert scale. Validity and reliability testing resulted in the decision to use a 14-item tool with a 0–3 Likert scale. The scale was found to have a Cronbach’s α coefficient of 0.839 (internal consistency), and there was strong inter-rater agreement (0.931). Conclusion: The assessment tool known as the Adolescent Behavioural Change Counselling Assessment Tool, is a valid and reliable instrument to measure Indonesian health professionals’ behavioural-change counselling skills with adolescent patients. The tool provides an evaluation framework for future interventions that aim to improve health professionals’ skills in addressing adolescent behaviour-related health problems. © The Author(s) 2024. |
Adolescent; Behaviour-change; Counselling skill; Health professionals; Non-communicable diseases; Quality |
Adolescent; Counseling; Delivery of Health Care; Health Behavior; Humans; Indonesia; Psychometrics; Reproducibility of Results; Surveys and Questionnaires; adolescent; counseling; health behavior; health care delivery; human; Indonesia; psychometry; questionnaire; reproducibility |
Maternal Health; Universitas Indonesia, UI, (00/2022, NKB–434/UN2, RST/ HKP.05); Ministry of Health of the Republic of Indonesia |
Funding text 1: The authors thank the Ministry of Health of the Republic of Indonesia, especially the director and the staff of The Directorate of Nutrition, Child and Maternal Health, the provincial health offices from 17 provinces and the clinical psychology team whose expertise greatly contributed to this assessment tool (Dian Oriza, Annisa Rahmalia, Utari Krisnamurthi, Sri Wulandari, Fina Dwi |
BioMed Central Ltd |
14726963 |
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38419005 |
Article |
Q1 |
964 |
4472 |
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7 |
Lubis A.M.T.; Prasetyo J.; Canintika A.F. |
Lubis, Andri Maruli Tua (15122639800); Prasetyo, Joseph (59002254800); Canintika, Anissa Feby (57208821931) |
15122639800; 59002254800; 57208821931 |
Isolated posterior cruciate ligament tears in monozygotic twins: A case report |
2024 |
International Journal of Surgery Case Reports |
119 |
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109682 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85191328847&doi=10.1016%2fj.ijscr.2024.109682&partnerID=40&md5=0972bb4f235ecada673c2cd82a8c8625 |
Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Lubis A.M.T., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Prasetyo J., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Canintika A.F., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction and importance: Posterior cruciate ligament (PCL) tears are not as frequent as anterior cruciate ligament (ACL) tears. They are rare as an isolated injury and more commonly occur in a multi-ligament-injured knee. We reported a case of rupture of PCL in monozygotic twins. Case presentation: A 19-year-old female presented with giving away of her left knee since 4 months ago. She fell from stairs previously. Physical examination demonstrated positive posterior drawer test. Magnetic resonance imaging showed ruptured PCL and lateral meniscal tear. Two months later, her identical twin, also a 19-year old-female, fell from the stairs and complained of giving away. Physical examination showed positive posterior drawer test. Magnetic resonance imaging demonstrated ruptured PCL and lateral meniscal tear. Both patients underwent arthroscopic-assisted PCL reconstruction using gracilis, semitendinosus, and peroneus tendon graft. At one year of follow-up, there were no graft failures. The twins had satisfactory outcome measured by Osteoarthritis Outcome Score (KOOS) and visual analogue scale (VAS). Both were athletes prior to their injury and they returned to sport. Clinical discussion: Although it has never been reported before, this report shows that patients may have genetic predisposition to the incidence of PCL rupture. This is likely because of heritable factors, such as biomechanical, anatomic, anthropometric, and neuromuscular traits. A family history of PCL tear may increase the risk of a PCL tear. Further studies are recommended to examine genetic variants as a risk factor for PCL tears and other knee disorders. Conclusions: Multiple variables may lead to the increased risk of these twins: the combination of improper neuromuscular control, genetic factors, and possibly hormonal factors contributed to their PCL injuries. Further history exploration, lab tests, and genetic analysis should be done to determine the variables. Both patients returned to sports protocol testing and returned to sports one year postoperatively. © 2024 |
Monozygotic twins; Posterior cruciate ligament tear |
adult; arthroscopic surgery; Article; athlete; case report; clinical article; female; follow up; gracilis muscle; human; Knee Injury and Osteoarthritis Outcome Score; knee meniscus rupture; lateral meniscus; monozygotic twins; nuclear magnetic resonance imaging; peroneal muscle; physical examination; posterior cruciate ligament reconstruction; posterior cruciate ligament rupture; quadriceps femoris muscle; return to sport; semitendinous muscle; tendon graft; visual analog scale; young adult |
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Elsevier Ltd |
22102612 |
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Article |
Q3 |
193 |
19555 |
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9 |
Fedrizal F.F.; Wijaya I.P.; Abdullah M.; Yamin M. |
Fedrizal, Fenandri Fadillah (57219280233); Wijaya, Ika Prasetya (57193731572); Abdullah, Murdani (7103393434); Yamin, Muhammad (23475706300) |
57219280233; 57193731572; 7103393434; 23475706300 |
Elevated neutrophyl-to-lymphocyte ratioand smoking are associated with chronic total occlusion in patients with ST elevation myocardial infarction |
2024 |
BMC Cardiovascular Disorders |
24 |
1 |
12 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85181244917&doi=10.1186%2fs12872-023-03680-3&partnerID=40&md5=9aaf3c2915cdc2583c57f09d4d1e5b80 |
Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Unit Epidemiology, Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Fedrizal F.F., Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Wijaya I.P., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Abdullah M., Unit Epidemiology, Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Yamin M., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Background: Atherosclerosis is a progressive disease characterized by the build-up of lipids and connective tissue in the large arteries. Some patients experience chronic total occlusion (CTO). Inflammation plays a key role in the development and complications of atherosclerosis. Neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation associated with the development of acute coronary syndrome (ACS). We aimed to assess the relationship between NLR and CTO in ACS patients with ST elevated myocardial infarction (STEMI) in Indonesia. Methods: This cross-sectional study was performed with secondary data obtained from patient medical records at Cipto Mangunkusumo National Central Hospital, Jakarta. Inclusion criteria were patients with ACS and STEMI who underwent coronary angiography in 2015–2018. Results: A total of 98 patients were enrolled in the analysis. Most subjects with CTO were male, elderly (> 60), smoking, had no history of diabetes mellitus (DM) or hypertension, no family history of coronary heart disease (CHD), but had a history of ACS and had never consumed statin or antiplatelet medications. Bivariate logistic regression analysis revealed that male gender (PR = 1.820; 95%CI 0.871–3.805; p = 0.025) and smoking (PR = 1.781; 95%CI 1.028–3.086; p = 0.004) were significantly correlated with CTO. Receiver operator characteristic (ROC) curve revealed that higher NLR (≥ 6.42) could predict a CTO diagnosis with positive predictive value (PPV) of 91%. Multivariate analysis revealed that NLR was correlated with an 11.2-fold increase in occurrence of CTO (95%CI 3.250-38.303; p < 0.001). Additionally, smoking was correlated with a 7-fold increase in CTO (95% CI 1.791–30.508; p = 0.006). Conclusion: NLR value of ≥ 6.42 is potentially useful as a marker of CTO in STEMI patients. In addition, smoking increases the risk of CTO in ACS/STEMI patients. © 2023, The Author(s). |
Chronic total occlusion; Coronary angiography; Coronary artery Disease; Myocardial Infarction; Neutrophil-to-lymphocyte ratio |
Acute Coronary Syndrome; Aged; Atherosclerosis; Chronic Disease; Coronary Occlusion; Cross-Sectional Studies; Female; Humans; Inflammation; Lymphocytes; Male; Percutaneous Coronary Intervention; Smoking; ST Elevation Myocardial Infarction; Treatment Outcome; antithrombocytic agent; hydroxymethylglutaryl coenzyme A reductase inhibitor; acute coronary syndrome; adult; age; aged; Article; bivariate analysis; cardiovascular risk; chronic total occlusion; controlled study; coronary angiography; cross-sectional study; diabetes mellitus; diagnostic test accuracy study; disease association; female; human; hypertension; Indonesia; ischemic heart disease; logistic regression analysis; major clinical study; male; medical record; multivariate analysis; neutrophil lymphocyte ratio; predictive value; re |
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BioMed Central Ltd |
14712261 |
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38172732 |
Article |
Q2 |
601 |
8561 |
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10 |
Amalia M.; Saputri F.C.; Sauriasari R.; Widyantoro B. |
Amalia, Muttia (57201697619); Saputri, Fadlina Chany (45561842900); Sauriasari, Rani (16246507200); Widyantoro, Bambang (35286148600) |
57201697619; 45561842900; 16246507200; 35286148600 |
Cholesterol low density lipoprotein associations with complete blood count parameters in atherosclerotic cardiovascular disease patients |
2024 |
AIP Conference Proceedings |
3155 |
1 |
030007 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85196498049&doi=10.1063%2f5.0218103&partnerID=40&md5=d5db89cbf03fdeda55e3adcd862fe364 |
Doctoral Program, Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Department of Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - National Cardiovascular Center, Harapan Kita, Jakarta, 11420, Indonesia |
Amalia M., Doctoral Program, Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Saputri F.C., Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Sauriasari R., Department of Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Widyantoro B., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - National Cardiovascular Center, Harapan Kita, Jakarta, 11420, Indonesia |
Cholesterol low density lipoprotein (LDL) is strongly associated with the development of atherosclerotic vascular disease (ASCVD). The objective of this study is to assess the relationships between cholesterol LDL and complete blood count (CBC) in ASCVD patients. This cross-sectional study was conducted at the National Cardiovascular Center Harapan Kita Jakarta. A total of 75 ASCVD patients from outpatient and emergency room departments were included in this study. The Chi-square test and the regression logistic analysis test were used to assess the relationships between cholesterol LDL and CBC. In this study, LDL level was found to be associated with the levels of leucocyte, percentage of eosinophil, percentage of lymphocyte, and absolute monocyte level. Lower eosinophil and lymphocyte levels were associated with increased LDL level. Regression logistic analysis revealed that the percentage of eosinophil (95%CI, 1.20 - 8.98; p value=0.02) and absolute monocyte (95%CI, 0.11 - 0.97; p value=0.04) were significant predictors of higher LDL levels in ASCVD. Increased inflammation due to elevated LDL may have resulted in circulating blood count alterations. Leucocytes and their differential count may aid in determining chronic inflammation and the progression of ASCVD. © 2024 Author(s). |
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American Institute of Physics |
0094243X |
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Conference paper |
- |
164 |
21059 |
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12 |
Kurniawan F.; Subekti I.; Yunir E.; Harbuwono D.S.; Purnamasari D.; Tarigan T.J.E.; Wisnu W.; Tahapary D.L.; Wafa S.; Astrella C.; Christabel E.V.; Lubis A.M.; Wijaya I.P.; Karim B.; Azizi M.S.; Suroyo I.; Matondang S.; Wicaksono K.P.; Wulandari D.; Fasha I.; Sartika C.R.; Irawan C.; Soewondo P. |
Kurniawan, Farid (57202309006); Subekti, Imam (24336854300); Yunir, Em (36520254800); Harbuwono, Dante Saksono (36056341600); Purnamasari, Dyah (36519537700); Tarigan, Tri Juli Edi (36057746500); Wisnu, Wismandari (57200425452); Tahapary, Dicky Levenus (55944492500); Wafa, Syahidatul (57208422885); Astrella, Cindy (57210793320); Christabel, Eunike Vania (57555549700); Lubis, Anna Mira (56702707800); Wijaya, Ika Prasetya (57193731572); Karim, Birry (57192910797); Azizi, Mohamad Syahrir (572095789 |
57202309006; 24336854300; 36520254800; 36056341600; 36519537700; 36057746500; 57200425452; 55944492500; 57208422885; 57210793320; 57555549700; 56702707800; 57193731572; 57192910797; 57209578916; 57204106272; 57192085914; 57219407117; 57204024903; 56114587600; 57205297509; 28767651600; 23475336100 |
Autologous intraarterial pancreatic bone-marrow mononuclear cells infusion in T2D patients: Changes on beta-cells function, insulin resistance, and inflammatory marker |
2024 |
Current Research in Translational Medicine |
72 |
2 |
103437 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85182889391&doi=10.1016%2fj.retram.2023.103437&partnerID=40&md5=aa6bb400dcc2bb93965a9eaa2c1dad78 |
Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Metabolic Disorder, Cardiovascular, and Aging Research Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Division of Hematology and Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Division of Cardiology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Clinical Pathology, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Prodia StemCell Indonesia, Jakarta, Indonesia |
Kurniawan F., Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Research Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Subekti I., Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Research Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Yunir E., Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Research Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Harbuwono D.S., Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Research Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Purnamasari D., Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Research Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Tarigan T.J.E., Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Research Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Wisnu W., Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Research Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Tahapary D.L., Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Research Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Wafa S., Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Research Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Astrella C., Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Christabel E.V., Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Lubis A.M., Division of Hematology and Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Wijaya I.P., Division of Cardiology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Karim B., Division of Cardiology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Azizi M.S., Division of Cardiology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Suroyo I., Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Matondang S., Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Wicaksono K.P., Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Wulandari D., Department of Clinical Pathology, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Fasha I., Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Sartika C.R., Prodia StemCell Indonesia, Jakarta, Indonesia; Irawan C., Division of Hematology and Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Soewondo P., Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Research Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: Type 2 diabetes (T2D) is a progressive disease. Many drugs currently being used for the management of T2D have minimal effect on pancreatic beta cells regeneration. Cell-based therapies might provide potential benefits in this aspect. Methods: A pilot study in five T2D patients with 12 months follow-up was performed to evaluate the effect of autologous bone marrow mononuclear stem cells (BM-MNCs) infusion into pancreatic arteries on the insulin requirement, beta-cell function, insulin resistance, and systemic inflammatory marker (CRP). Results: The primary endpoint, a 50 % reduction of total insulin doses from baseline, was not achieved in this study. However, a trend of increasing fasting C-peptide (p = 0.07) and C-peptide 60′ (p = 0.07) and 90′ (p = 0.07) after a mixed-meal tolerance test was observed 12 months post-infusion compared to baseline levels. A similar result was observed for the homeostatic model assessment of beta cell function (HOMA1-B), an index for beta cell function. No improvement was observed for insulin resistance measured by homeostasis model assessment of insulin resistance (HOMA1-IR) and systemic inflammatory parameter. Conclusion: Intraarterial pancreatic autologous BM-MNCs infusion might potentially improve beta cell function in T2D patients, although further study is needed to confirm this finding. © 2023 |
Autologous bone marrow mononuclear stem cells; Insulin resistance; Intraarterial pancreas; Pancreatic beta-cells function; Type 2 diabetes mellitus |
Adult; Aged; Biomarkers; Bone Marrow Transplantation; C-Peptide; Diabetes Mellitus, Type 2; Female; Humans; Inflammation; Infusions, Intra-Arterial; Insulin; Insulin Resistance; Insulin-Secreting Cells; Leukocytes, Mononuclear; Male; Middle Aged; Pancreas; Pilot Projects; Transplantation, Autologous; C peptide; C reactive protein; glucose; hemoglobin A1c; insulin; biological marker; C peptide; insulin; adult; Article; autologous intraarterial pancreatic bone marrow mononuclear cell transplantation; bone marrow aspiration; cell transplantation; clinical article; controlled study; enzyme linked immunosorbent assay; female; follow up; glucose blood level; homeostasis model assessment; homeostatic model assessment of beta cell function; human; human cell; human tissue; insulin resistance; male |
Universitas Indonesia, UI |
This work was supported by the Prototype Design (PHD PRO) Grant 2020 from University of Indonesia . |
Elsevier Masson s.r.l. |
24523186 |
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38244275 |
Article |
Q2 |
840 |
5558 |
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15 |
Harzif A.K.; Andyra A.F.; Sayogo A.; Ummah N.; Puspawardani A.R.; Nurbaeti P.; Wiweko B. |
Harzif, Achmad Kemal (57191493435); Andyra, Azizah Fitriayu (57438092800); Sayogo, Atikah (58945649000); Ummah, Nafi’atul (58945649100); Puspawardani, Aisyah Retno (58944793100); Nurbaeti, Putri (58945649200); Wiweko, Budi (43061741400) |
57191493435; 57438092800; 58945649000; 58945649100; 58944793100; 58945649200; 43061741400 |
Embryo response to aneuploidy through self-correction mechanism: a literature review |
2024 |
Middle East Fertility Society Journal |
29 |
1 |
16 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85188103317&doi=10.1186%2fs43043-024-00176-8&partnerID=40&md5=2ea59e3b8e555f1604df15976d449b84 |
Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Yasmin IVF Clinic Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Harzif A.K., Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Yasmin IVF Clinic Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Andyra A.F., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sayogo A., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ummah N., Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Puspawardani A.R., Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Nurbaeti P., Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wiweko B., Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Yasmin IVF Clinic Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Meiotic and mitotic errors often lead to aneuploidy and mosaicism. In this context, the self-correction mechanism enables the embryo to preferentially retain and preserve euploid cells through processes such as apoptosis, necrosis, or marginalization. This mechanism is thought to minimize the chance of genetic abnormalities during cell development. Materials and methods: A literature search for articles written in English from January 2013 to October 2023 was conducted on PubMed, EBSCO, and Scopus, using the keywords “self-correction,” “self-repair,” “aneuploidy,” “mosaicism,” and “embryo.” Results: A total of 308 articles were collected, out of which 5 retrospective and 1 prospective study were selected based on inclusion criteria. Discussions: Investigations showed that embryos remove chromosomally abnormal cells, supporting the self-correction mechanism. aCGH has been used in 4 studies to demonstrate the presence of self-correction in mosaic embryos. Furthermore, a higher relative viability of polyploidies than complex aneuploidies was observed, suggesting early discrimination against complex aneuploidy, particularly those arising from mitotic origins. However, there are doubts about the reliability of preimplantation genetic testing for aneuploidy at the blastocyst stage, as it may lead to a high rate of false positives and the discarding of "good" embryos. Conclusions: Studies showed a self-correction mechanism in human embryos through the ability to expel abnormal cells. Further investigation is needed to elucidate the underlying mechanisms and determine optimal strategies for preimplantation genetic testing to fully understand and optimize the use of self-correction mechanisms in embryo assessment and selection. © The Author(s) 2024. |
Aneuploidy; Embryo; Mosaicism; Self-correction; Self-repair |
aneuploidy; blastocyst; blastomere; chromosome 19; chromosome aberration; comparative genomic hybridization; cytogenetic analysis; embryo; embryo (anatomy); embryo biopsy; embryo development; false positive result; high throughput sequencing; human; human embryo; mosaicism; polymerase chain reaction; polyploidy; preimplantation genetic screening; Review; single nucleotide polymorphism array; trophectoderm; uniparental disomy; X chromosome |
Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia |
The authors would like to express gratitude to the Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, for supporting this study. |
Springer Science and Business Media Deutschland GmbH |
11105690 |
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Review |
Q3 |
322 |
14459 |
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16 |
Prawiroharjo P.; Anggraini H.; Geraldi I.P.; Octaviana F.; Budikayanti A.; Safri A.Y.; Wiratman W.; Indrawati L.A.; Fadli N.; Harsono A.R.; Hakim M. |
Prawiroharjo, Pukovisa (57195838668); Anggraini, Hikma (59124155100); Geraldi, Iskandar Purba (58116732300); Octaviana, Fitri (26029958700); Budikayanti, Astri (57194713932); Safri, Ahmad Yanuar (57091699300); Wiratman, Winnugroho (57191920526); Indrawati, Luh Ari (57205117182); Fadli, Nurul (58772486600); Harsono, Adrian Ridski (59011489600); Hakim, Manfaluthy (57216861859) |
57195838668; 59124155100; 58116732300; 26029958700; 57194713932; 57091699300; 57191920526; 57205117182; 58772486600; 59011489600; 57216861859 |
Factors correlating to decisions for prescribing pharmacological treatment and referrals in suspected peripheral neuropathy cases in chat consultation-based application |
2024 |
Heliyon |
10 |
10 |
e30713 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85192934441&doi=10.1016%2fj.heliyon.2024.e30713&partnerID=40&md5=8df51869c2fab92bbe63df29c1ff5e0a |
Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia; Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia; Department of Neurology, Universitas Indonesia Hospital, Indonesia |
Prawiroharjo P., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia, Department of Neurology, Universitas Indonesia Hospital, Indonesia; Anggraini H., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia; Geraldi I.P., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia; Octaviana F., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia; Budikayanti A., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia; Safri A.Y., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia; Wiratman W., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia, Department of Neurology, Universitas Indonesia Hospital, Indonesia; Indrawati L.A., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia; Fadli N., Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia, Department of Neurology, Universitas Indonesia Hospital, Indonesia; Harsono A.R., Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia, Department of Neurology, Universitas Indonesia Hospital, Indonesia; Hakim M., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia |
Introduction: Since the COVID-19 pandemic, there has been increasing use ofchat-based telemedicine, including for patients with neuropathy complaints. It is imperative to learn how to effectively use telemedicine. This study describes the characteristics of patients with neuropathy complaints in chat-based telemedicine services in Indonesia and their influence on treatment decisions and referrals. Methods: This is a retrospective cross-sectional study during the COVID-19 pandemic era (March 2020 to December 2021) using anonymous secondary data from patient chat databases on Indonesian application-based telemedicine services (Halodoc, Alodokter, Good Doctor, and Milvik). We applied bivariate and multivariate analysis. Results: We obtained 1051 patients with suspected peripheral nerve complaints (4 per 10,000) from a total of 2,199,527 user consultations, with the majority being 40–64 years old females and diabetes mellitus was the leading comorbid (90.7%). Most patients received treatment (90.7%) and only 11.4% patients were referred. Multivariate analysis showed that treatment was more likely to be given by a neurologist (p < 0.01). Chronic symptoms (p < 0.01) and previous laboratory/other tests (p = 0.01) decreased the likelihood of medication prescription. Referrals were more likely to be given to chronic onset (p = 0.02), hypertension and heart disease (p < 0.01), and previous laboratory/other tests (p = 0.02). The opposite was true for age≥65 years, female (p = 0.04), and neurologists or other specialists as responders (p < 0.01). Conclusion: We identified several factors that influence the treatment decision such as female patients and onset. Meanwhile, age, sex, chronic symptoms, history of hypertension and heart disease, and previous laboratory/other tests may influence the referral decisions. General practitioners were more likely to refer the patients whereas neurologists or other specialists were more likely to give treatment. Chat-based telemedicine services can still be developed in the future to be better. © 2024 |
Chat; Clinical decision making; Neuropathic pain; Neuropathy complaints; Paresthesia; Telemedicine |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
609 |
8422 |
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18 |
Tenggara J.B.; Rachman A.; Prihartono J.; Rachmadi L.; Panigoro S.S.; Heriyanto D.S.; Sutandyo N.; Nasution I.R.; Rahadiati F.B.; Steven R.; Betsy R.; Juanputra S.; Sudoyo A.W. |
Tenggara, Jeffry Beta (26028154300); Rachman, Andhika (15056701600); Prihartono, Joedo (6602605635); Rachmadi, Lisnawati (55062422000); Panigoro, Sonar Soni (56790104300); Heriyanto, Didik Setyo (54420130300); Sutandyo, Noorwati (26028099200); Nasution, Intan Russianna (58856886500); Rahadiati, Familia Bella (57222312428); Steven, Ricci (58808727700); Betsy, Rachelle (58035832700); Juanputra, Samuel (58035300800); Sudoyo, Aru Wisaksono (6507478291) |
26028154300; 15056701600; 6602605635; 55062422000; 56790104300; 54420130300; 26028099200; 58856886500; 57222312428; 58808727700; 58035832700; 58035300800; 6507478291 |
The relationship between high ratios of CD4/FOXP3 and CD8/CD163 and the improved survivability of metastatic triple-negative breast cancer patients: a multicenter cohort study |
2024 |
BMC Research Notes |
17 |
1 |
44 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85183752630&doi=10.1186%2fs13104-024-06704-z&partnerID=40&md5=de027f325777bb9ecbe793095eb9ae40 |
Division of Hematology and Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital–Faculty of Medicine Universitas Indonesia, Jl. Pangeran Diponegoro No. 71, RW.5, Kec. Senen, Central Jakarta, Jakarta, 10430, Indonesia; Division of Hematology and Medical Oncology, Department of Internal Medicine, MRCCC Siloam Hospital Jakarta, Jakarta, Indonesia; Department of Community Medicine, Dr. Cipto Mangunkusumo General Hospital–Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomical Pathology, Dr. Cipto Mangunkusumo General Hospital–Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Surgical Oncology, Dr. Cipto Mangunkusumo General Hospital–Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomical Pathology, Dr. Sardjito Hospital–Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Division of Hematology and Medical Oncology, Department of Internal Medicine, Dharmais National Cancer Hospital, Jakarta, Indonesia; Division of Hematology and Medical Oncology, Gatot Soebroto Army Hospital Jakarta, Jakarta, Indonesia; Department of Anatomical Pathology, Gatot Soebroto Army Hospital Jakarta, Jakarta, Indonesia; Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital–Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Tenggara J.B., Division of Hematology and Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital–Faculty of Medicine Universitas Indonesia, Jl. Pangeran Diponegoro No. 71, RW.5, Kec. Senen, Central Jakarta, Jakarta, 10430, Indonesia, Division of Hematology and Medical Oncology, Department of Internal Medicine, MRCCC Siloam Hospital Jakarta, Jakarta, Indonesia; Rachman A., Division of Hematology and Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital–Faculty of Medicine Universitas Indonesia, Jl. Pangeran Diponegoro No. 71, RW.5, Kec. Senen, Central Jakarta, Jakarta, 10430, Indonesia, Division of Hematology and Medical Oncology, Department of Internal Medicine, MRCCC Siloam Hospital Jakarta, Jakarta, Indonesia; Prihartono J., Department of Community Medicine, Dr. Cipto Mangunkusumo General Hospital–Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rachmadi L., Department of Anatomical Pathology, Dr. Cipto Mangunkusumo General Hospital–Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Panigoro S.S., Department of Surgical Oncology, Dr. Cipto Mangunkusumo General Hospital–Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Heriyanto D.S., Department of Anatomical Pathology, Dr. Sardjito Hospital–Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Sutandyo N., Division of Hematology and Medical Oncology, Department of Internal Medicine, Dharmais National Cancer Hospital, Jakarta, Indonesia; Nasution I.R., Division of Hematology and Medical Oncology, Gatot Soebroto Army Hospital Jakarta, Jakarta, Indonesia; Rahadiati F.B., Department of Anatomical Pathology, Gatot Soebroto Army Hospital Jakarta, Jakarta, Indonesia; Steven R., Division of Hematology and Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital–Faculty of Medicine Universitas Indonesia, Jl. Pangeran Diponegoro No. 71, RW.5, Kec. Senen, Central Jakarta, Jakarta, 10430, Indonesia, Division of Hematology and Medical Oncology, Department of Internal Medicine, MRCCC Siloam Hospital Jakarta, Jakarta, Indonesia; Betsy R., Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital–Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Juanputra S., Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital–Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sudoyo A.W., Division of Hematology and Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital–Faculty of Medicine Universitas Indonesia, Jl. Pangeran Diponegoro No. 71, RW.5, Kec. Senen, Central Jakarta, Jakarta, 10430, Indonesia, Division of Hematology and Medical Oncology, Department of Internal Medicine, MRCCC Siloam Hospital Jakarta, Jakarta, Indonesia |
Background: Triple-negative breast cancer (TNBC) has been documented as the most aggressive subtype of breast cancer. This study aimed to analyze antitumor and protumor immune activities, and their ratios as significant prognostic biomarkers in metastatic TNBC (mTNBC). Methods: A multicenter cohort study was conducted among 103 de novo mTNBC patients. The expression of CD8 and CD163 was evaluated using immunohistochemistry staining, CD4 and FOXP3 using double-staining immunohistochemistry, and PD-L1 using immunohistochemistry and RT-PCR. Results: Multivariate analysis revealed that high CD4/FOXP3 (HR 1.857; 95% CI 1.049–3.288; p = 0.034) and the CD8/CD163 ratio (HR 2.089; 95% CI 1.174–3.717; p = 0.012) yield significantly improved 1 year overall survival (OS). Kaplan–Meier analysis showed that high levels of CD4 (p = 0.023), CD8 (p = 0.043), CD4/FOXP3 (p = 0.016), CD8/FOXP3 (p = 0.005), CD8/CD163 (p = 0.005) ratios were significantly associated with higher rate of 1 year OS. Furthermore, 1 year OS was directly correlated with antitumor CD4 (R = 0.233; p = 0.018) and CD8 (R = 0.219; p = 0.026) and was indirectly correlated with protumor CD163 and FOXP3 through CD4/FOXP3 (R = 0.282; p = 0.006), CD4/CD163 (R = 0.239; p = 0.015), CD8/FOXP3 (R = 0.260; p = 0.008), and CD8/CD163 (R = 0.258; p = 0.009). Conclusion: This is the first study to demonstrate that high levels of CD4/FOXP3 and CD8/CD163 significantly improved the 1 year OS in de novo mTNBC patients. Thus, we recommend the application of these markers as prognosis determination and individual treatment decision. © 2024, The Author(s). |
CD163; CD4; CD8; FOXP3; Metastatic; Survival; Triple-negative breast cancer |
B7-H1 Antigen; CD8-Positive T-Lymphocytes; Cohort Studies; Forkhead Transcription Factors; Humans; Lymphocytes, Tumor-Infiltrating; Neoadjuvant Therapy; Triple Negative Breast Neoplasms; forkhead transcription factor; FOXP3 protein, human; programmed death 1 ligand 1; CD8+ T lymphocyte; clinical trial; cohort analysis; genetics; human; metabolism; multicenter study; neoadjuvant therapy; pathology; triple negative breast cancer; tumor associated leukocyte |
Department of Anatomical Pathology; Department of Internal Medicine, University of Utah; Department of Radiology, Weill Cornell Medical College |
The authors gratefully acknowledged all staff of the medical record, the Department of Radiology, the Department of Hematology and Medical Oncology, the Department of Anatomical Pathology (Deny Suprihatin), and the Clinical Epidemiology Division, Department of Internal Medicine (Utami Susilowati). |
BioMed Central Ltd |
17560500 |
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38308298 |
Article |
Q2 |
534 |
9718 |
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