No records
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1 |
Khudri G.; Sukmawati D. |
Khudri, Ghaniyyatul (59154919100); Sukmawati, Dewi (55615650900) |
59154919100; 55615650900 |
Exploring hematopoietic stem cell population in human milk and its benefits for infants: A scoping review |
2024 |
Asian Pacific Journal of Reproduction |
13 |
3 |
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107 |
114 |
7 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85195080927&doi=10.4103%2fapjr.apjr_108_23&partnerID=40&md5=ccb5b4e1c6fb2a637aebbc0d8043d031 |
Department of Histology, Faculty of Medicine, Universitas Baiturrahmah, Padang, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Khudri G., Department of Histology, Faculty of Medicine, Universitas Baiturrahmah, Padang, Indonesia; Sukmawati D., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Objective: To comprehensively explore hematopoietic stem cells (HSCs) in human milk, understanding their molecular markers, isolation methods, benefits for infants, and potential medical applications. Methods: We conducted a scoping literature review following the PRISMA-ScR guidelines. This review included studies investigating HSCs in human milk, utilizing molecular markers such as CD34 +, CD113 +, and CD117 + for characterization. Both in vitro and in vivo studies exploring the morphology, function, and clinical implications of these cells were considered. The diverse range of papers reviewed were indexed in PubMed, Science Direct, Scopus, Sage Journals, and Google Scholar, published between 2010 and 2023. Results: This scoping review explored 577 articles and selected 13 studies based on our inclusion criteria, focusing on HSCs in human milk. Most studies dilute samples prior to HSC isolation, followed by detection using markers such as CD34 +, CD113 +, and CD117 +, with flow cytometry serving as the primary analysis tool, focusing on their isolation and detection methods. While no definitive benefits have been conclusively established, there is a strong belief in the potential of HSCs to positively impact infant immunity, growth, and tissue repair. Conclusions: This review presents significant evidence supporting the presence of HSCs in human milk, identified by markers such as CD34 +, CD113 +, and CD117 +. These cells show considerable potential in enhancing infant health, including immunity, tissue repair, cognitive development, and gastrointestinal health. Despite methodological variations in isolation and detection techniques, the collective findings underscore the potential clinical relevance of HSCs in human milk. Moreover, this review highlights the non-invasive accessibility of human milk as a source of HSCs and emphasizes the need for further research to unlock their therapeutic potential. © 2024 Asian Pacific Journal of Reproduction. |
CD34 +; Cellular components; Hematopoietic stem cells; Human milk; Stem cells |
cd113 antigen; CD133 antigen; CD34 antigen; lymphocyte antigen; octamer transcription factor 4; receptor type tyrosine protein phosphatase C; stem cell factor receptor; Thy 1 membrane glycoprotein; transcription factor NANOG; transcription factor Sox2; unclassified drug; breast milk; cell culture; cell function; cell isolation; cell population; cell structure; child health; cognition; flow cytometry; hematopoietic stem cell; human; immunocytochemistry; immunofluorescence assay; in vitro study; in vivo study; kangaroo care; lactocyte; myoepithelium cell; passive immunization; Preferred Reporting Items for Systematic Reviews and Meta-Analyses; real time reverse transcription polymerase chain reaction; Review; stem cell; systematic review; tooth development |
National Research and Innovation Agency of Republic of Indonesia; Badan Riset dan Inovasi Nasional, BRIN; Institute of Education Fund Management; Lembaga Pengelola Dana Pendidikan, LPDP |
This study is supported by the National Research and Innovation Agency of Republic of Indonesia (BRIN) - RIIM Batch-2 2022 research grants and the Institute of Education Fund Management (Lembaga Pengelola Dana Pendidikan - LPDP). |
Wolters Kluwer Medknow Publications |
23050500 |
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Review |
Q3 |
191 |
19638 |
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2 |
Chenderawasi S.; Dharma R.; Pohan H.T.; Dewi B.E.; Setiabudy R.; Suhendro; Aryati; Darmawan H.; Nainggolan L.; Iskandar A. |
Chenderawasi, Settrin (57221643087); Dharma, Rahajuningsih (12777817700); Pohan, Herdiman T. (23474782900); Dewi, Beti Ernawati (24076058600); Setiabudy, Rianto (6602316235); Suhendro (57215086884); Aryati (57209860388); Darmawan, Hardi (8581795700); Nainggolan, Leonard (23498394800); Iskandar, Agustin (37079172000) |
57221643087; 12777817700; 23474782900; 24076058600; 6602316235; 57215086884; 57209860388; 8581795700; 23498394800; 37079172000 |
Cut-off Value of HSPG for Early Marker of Plasma Leakage in Adult Dengue Patient |
2024 |
Indonesian Journal of Clinical Pathology and Medical Laboratory |
30 |
3 |
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259 |
264 |
5 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85196512724&doi=10.24293%2fijcpml.v30i3.2221&partnerID=40&md5=c691867fc67c7f2904e3cec2a9cfba6b |
Community-Based Dengue Study, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Clinical Pathology, University of Indonesia, Jakarta, Indonesia; Department of Internal Medicine, University of Indonesia, Jakarta, Indonesia; Department of Microbiology, University of Indonesia, Jakarta, Indonesia; Department of Pharmacology, University of Indonesia, Jakarta, Indonesia; Department of Clinical Pathology, Airlangga University, Surabaya, Indonesia; Department of Physiology, University of Sriwijaya, Palembang, Indonesia; Department of Clinical Pathology, Brawijaya University, Malang, Indonesia |
Chenderawasi S., Community-Based Dengue Study, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Dharma R., Department of Clinical Pathology, University of Indonesia, Jakarta, Indonesia; Pohan H.T., Department of Internal Medicine, University of Indonesia, Jakarta, Indonesia; Dewi B.E., Community-Based Dengue Study, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Department of Microbiology, University of Indonesia, Jakarta, Indonesia; Setiabudy R., Department of Pharmacology, University of Indonesia, Jakarta, Indonesia; Suhendro, Department of Internal Medicine, University of Indonesia, Jakarta, Indonesia; Aryati, Department of Clinical Pathology, Airlangga University, Surabaya, Indonesia; Darmawan H., Department of Physiology, University of Sriwijaya, Palembang, Indonesia; Nainggolan L., Community-Based Dengue Study, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Department of Internal Medicine, University of Indonesia, Jakarta, Indonesia; Iskandar A., Department of Clinical Pathology, Brawijaya University, Malang, Indonesia |
Plasma leakage is a state of increased vascular permeability due to loss of interendothelial junction and focal adhesion. Endothelium glycocalyx plays a major role in the pathogenesis of plasma leakage. Proteoglycans glycocalyx consists of heparan sulfate (HSPG) around 50-90%. Plasma leakage in dengue infection can be fatal and early detection is essential. This study aimed to determine the optimal cut-off value of HSPG levels for early marker of plasma leakage in dengue infection. The study was a retrospective cohort study as a part of the Community Based Dengue Study of the Faculty of Medicine, University of Indonesia, which was conducted between February 2010 and January 2011. Subjects were recruited by consecutive sampling. Dengue infection was confirmed by conventional PCR serotyping. Subjects were categorized into 2 groups, i.e. those with and without plasma leakage. Plasma leakage was confirmed by hemoconcentration or hypoalbuminemia or USG results. The level of HSPG was measured using the ELISA method from the first until the third day of the hospital admission. A total of 40 subjects were involved in this study, consisting of 21 with leakage and 19 without st nd leakage. The optimal cut-off level of HSPG as a marker of early plasma leakage in dengue infection patients on the 1 day, 2 rd day, and 3 day was was 2179.73 pg/mL, 2538.66 pg/mL, and 1294.06 pg/mL, respectively. HSPG could as an early marker of plasma leakage in dengue infection with an optimal cut-off value for each of the first 3 days of the patient's fever. A pediatric study was recommended to obtain the optimal cut-off value for HSPG. © 2024, Indonesian Association of Clinical Pathology and Laboratory Medicine. All rights reserved. |
Dengue; HSPG; plasma leakage marker |
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Community Based Dengue Study Faculty of Medicine Universitas Indonesia |
This study was supported by the Community Based Dengue Study Faculty of Medicine Universitas Indonesia. |
Indonesian Association of Clinical Pathology and Laboratory Medicine |
24774685 |
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Article |
#N/A |
#N/A |
#N/A |
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4 |
Rahayu D.; Meutia A.P.; Priyatini T.; Suratih N.M.D.; Maidarti M.; Harzif A.K.; Muharam R.; Pratama G. |
Rahayu, Deniswari (57208300474); Meutia, Alfa Putri (57203368133); Priyatini, Tyas (57192265423); Suratih, Ni Made Desy (26634582200); Maidarti, Mila (56320510400); Harzif, Achmad Kemal (57191493435); Muharam, R. (57191492732); Pratama, Gita (58162878900) |
57208300474; 57203368133; 57192265423; 26634582200; 56320510400; 57191493435; 57191492732; 58162878900 |
Association of hirsutism and anthropometric profiles with sexual dysfunction and anxiety levels in infertile Indonesian women with polycystic ovarian syndrome |
2024 |
Middle East Fertility Society Journal |
29 |
1 |
19 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85189636536&doi=10.1186%2fs43043-024-00178-6&partnerID=40&md5=22df206c1e005692cbf08891765f633a |
Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Urogynecology and Reconstructive Pelvic Surgery Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Reproductive Endocrinology Division, Department of Obstetrics and Gynecology, Persahabatan General Hospital, Jakarta, Indonesia; Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Yasmin IVF Clinic Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Rahayu D., Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Meutia A.P., Urogynecology and Reconstructive Pelvic Surgery Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Priyatini T., Urogynecology and Reconstructive Pelvic Surgery Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Suratih N.M.D., Reproductive Endocrinology Division, Department of Obstetrics and Gynecology, Persahabatan General Hospital, Jakarta, Indonesia; Maidarti M., Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Yasmin IVF Clinic Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Harzif A.K., Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Yasmin IVF Clinic Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Muharam R., Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Yasmin IVF Clinic Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Pratama G., Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Yasmin IVF Clinic Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Background: Hyperandrogenism is frequently found in polycystic ovary syndrome (PCOS) and contributes to physical manifestations like hirsutism and obesity, along with infertility. This condition can result in anxiety, depression, and body image disorders, potentially leading to sexual dysfunction. The objective of this investigation was to assess the correlation among hirsutism, anthropometric characteristics, sexual dysfunction, and anxiety levels among infertile Indonesian women diagnosed with PCOS. Methods: From December 2021 to December 2022, a cross-sectional study was undertaken involving 71 infertile women diagnosed with PCOS at Yasmin Clinic, Dr. Cipto Mangunkusumo General Hospital in Jakarta, Indonesia. Hirsutism was assessed using the modified Ferriman-Gallwey (mFG) score; the anthropometric profile was assessed using BMI and waist-to-hip ratio. The assessment of sexual dysfunction was conducted using the Female Sexual Function Index (FSFI) questionnaire, while the evaluation of anxiety levels utilized the HAM-A questionnaires. Results: In this study, it was discovered that 53.3% of subjects experienced sexual dysfunction. However, there was no statistically significant relationship between hirsutism, anthropometric profile, and sexual dysfunction score in infertile women with PCOS (p > 0.05). Analysis of the overall FSFI domain score revealed that lubrication and satisfaction were lower in obese patients (p = 0.02 and p = 0.03), but this did not contribute to an overall sexual dysfunction score. Also, we found that subjects who experienced sexual dysfunction had a higher anxiety score (p < 0.005), with correlation analysis showing that Ferriman-Gallwey (FG) scores have a significant positive correlation with anxiety. Conclusion: There is no correlation between hirsutism, anthropometric profile, and sexual dysfunction in infertile Indonesian women diagnosed with PCOS. However, hirsutism could play a role in causing anxiety in Indonesian PCOS women. Additional investigation is required, as female sexual function is an intricate subject. © The Author(s) 2024. |
Anthropometric profile; Hyperandrogenism; Infertility; PCOS; Polycystic ovarian syndrome; Sexual dysfunction |
contraceptive agent; follitropin; luteinizing hormone; adult; anthropometric parameters; anxiety disorder; arousal; Article; automation; body height; body mass; body weight; correlational study; cross-sectional study; dyspareunia; educational status; employee; employment status; female; female infertility; Female Sexual Function Index; Hamilton Anxiety Scale; hip circumference; hirsutism; human; hyperandrogenism; Indonesian; intra-abdominal fat; laboratory test; lubrication; major clinical study; modified ferriman gallwey score; obese patient; obesity; orgasm; ovary polycystic disease; patient satisfaction; pleasure; prevalence; questionnaire; sexual dysfunction; sexual function; skin disease assessment; social status; subcutaneous fat; transvaginal echography; unemployment; waist circumfe |
Indonesian Reproductive Medicine Research and Training Center; INAREPROMED; PUTI Saintekes 2020, (NKB-2278/UN.2) |
Funding text 1: The authors express gratitude to the Indonesian Reproductive Medicine Research and Training Center (INAREPROMED) and the teams at Yasmin Clinic and Rumah Sakit Dr. Cipto Mangunkusumo Hospital for their invaluable assistance and support throughout this study.; Funding text 2: This study received funding from the PUTI Saintekes 2020 grant, contract number NKB-2278/UN.2.RST/HKP.05.00. |
Springer Science and Business Media Deutschland GmbH |
11105690 |
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Article |
Q3 |
322 |
14459 |
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6 |
Soetisna T.W.; Thamrin A.M.H.; Ramadhani A.N.E.; Permadijana D.; Elfian M.A.; Hendarto H. |
Soetisna, Tri Wisesa (57214887740); Thamrin, Ahmad Muslim Hidayat (58192261300); Ramadhani, Andi Nurul Erisya (58489887400); Permadijana, Diajeng (58492411600); Elfian, Muhammad Alghifari (59152843500); Hendarto, Hari (55206713900) |
57214887740; 58192261300; 58489887400; 58492411600; 59152843500; 55206713900 |
Systematic Review of Stem Cell Therapy for Ischemic Heart Disease in Indonesia: Where Are We Now? |
2024 |
Malaysian Journal of Medicine and Health Sciences |
20 |
3 |
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298 |
306 |
8 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85194956672&doi=10.47836%2fmjmhs.20.3.40&partnerID=40&md5=9142c7b56db0c3e4b8b7a22981bd7e4e |
Adult Cardiac Surgery Division, Department of Thoracic and Cardiovascular Surgery, Harapan Kita National Cardiovascular Center Hospital, Jakarta, Indonesia; Faculty of Medicine Syarif Hidayatullah State Islamic University, Haji Hospital, Jakarta, Indonesia; Department of Thoracic and Cardiovascular Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Soetisna T.W., Adult Cardiac Surgery Division, Department of Thoracic and Cardiovascular Surgery, Harapan Kita National Cardiovascular Center Hospital, Jakarta, Indonesia, Faculty of Medicine Syarif Hidayatullah State Islamic University, Haji Hospital, Jakarta, Indonesia; Thamrin A.M.H., Adult Cardiac Surgery Division, Department of Thoracic and Cardiovascular Surgery, Harapan Kita National Cardiovascular Center Hospital, Jakarta, Indonesia, Department of Thoracic and Cardiovascular Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Ramadhani A.N.E., Adult Cardiac Surgery Division, Department of Thoracic and Cardiovascular Surgery, Harapan Kita National Cardiovascular Center Hospital, Jakarta, Indonesia; Permadijana D., Adult Cardiac Surgery Division, Department of Thoracic and Cardiovascular Surgery, Harapan Kita National Cardiovascular Center Hospital, Jakarta, Indonesia; Elfian M.A., Adult Cardiac Surgery Division, Department of Thoracic and Cardiovascular Surgery, Harapan Kita National Cardiovascular Center Hospital, Jakarta, Indonesia; Hendarto H., Department of Thoracic and Cardiovascular Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Introduction: Heart failure due to IHD is one of the most common causes of morbidity in Indonesia. The promising stem cell therapy for IHD patients has been conducted in Indonesia since 12 years ago but limited results of publications are available. We conducted a systematic review to evaluate the progress of stem cell therapy for IHD patients in Indonesia. Methods: A systematic review was conducted according to the PRISMA guidelines. A comprehensive literature search was performed using the PubMed, Scopus, and Embase databases from March – April 2023. Articles are thoroughly evaluated and analyzed. Results: Four publications from Indonesia related to stem cell therapy for IHD patients are included. Clinical outcome was measured by LVEF, WMSI, and 6-MWT. Safety outcomes are also measured. Follow-up time ranged from 6 – 12 months. Significant improvement in most of the LVEF, WMSI, and 6-MWT studies. Safety outcome measures demonstrated relatively low rates of AE after stem cell transplantation and no cardiac event-related deaths were reported. Conclusion: Stem cell therapy trials for IHD in Indonesia show promising results in improving ventricular function and daily functional outcomes safely. With the fast-growing trend of stem cells and cardiovascular centers in Indonesia, we hope that more well-designed clinical trials with long-term outcome assessments can be conducted to confirm these results. © 2024 Universiti Putra Malaysia Press. All rights reserved. |
Indonesia; Ischemic heart disesase; Outcome; Safety; Sstem cell |
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Universiti Putra Malaysia Press |
16758544 |
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Article |
Q4 |
139 |
22705 |
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7 |
Lubis A.M.T.; Prasetyo J.; Canintika A.F. |
Lubis, Andri Maruli Tua (15122639800); Prasetyo, Joseph (59002254800); Canintika, Anissa Feby (57208821931) |
15122639800; 59002254800; 57208821931 |
Isolated posterior cruciate ligament tears in monozygotic twins: A case report |
2024 |
International Journal of Surgery Case Reports |
119 |
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109682 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85191328847&doi=10.1016%2fj.ijscr.2024.109682&partnerID=40&md5=0972bb4f235ecada673c2cd82a8c8625 |
Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Lubis A.M.T., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Prasetyo J., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Canintika A.F., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction and importance: Posterior cruciate ligament (PCL) tears are not as frequent as anterior cruciate ligament (ACL) tears. They are rare as an isolated injury and more commonly occur in a multi-ligament-injured knee. We reported a case of rupture of PCL in monozygotic twins. Case presentation: A 19-year-old female presented with giving away of her left knee since 4 months ago. She fell from stairs previously. Physical examination demonstrated positive posterior drawer test. Magnetic resonance imaging showed ruptured PCL and lateral meniscal tear. Two months later, her identical twin, also a 19-year old-female, fell from the stairs and complained of giving away. Physical examination showed positive posterior drawer test. Magnetic resonance imaging demonstrated ruptured PCL and lateral meniscal tear. Both patients underwent arthroscopic-assisted PCL reconstruction using gracilis, semitendinosus, and peroneus tendon graft. At one year of follow-up, there were no graft failures. The twins had satisfactory outcome measured by Osteoarthritis Outcome Score (KOOS) and visual analogue scale (VAS). Both were athletes prior to their injury and they returned to sport. Clinical discussion: Although it has never been reported before, this report shows that patients may have genetic predisposition to the incidence of PCL rupture. This is likely because of heritable factors, such as biomechanical, anatomic, anthropometric, and neuromuscular traits. A family history of PCL tear may increase the risk of a PCL tear. Further studies are recommended to examine genetic variants as a risk factor for PCL tears and other knee disorders. Conclusions: Multiple variables may lead to the increased risk of these twins: the combination of improper neuromuscular control, genetic factors, and possibly hormonal factors contributed to their PCL injuries. Further history exploration, lab tests, and genetic analysis should be done to determine the variables. Both patients returned to sports protocol testing and returned to sports one year postoperatively. © 2024 |
Monozygotic twins; Posterior cruciate ligament tear |
adult; arthroscopic surgery; Article; athlete; case report; clinical article; female; follow up; gracilis muscle; human; Knee Injury and Osteoarthritis Outcome Score; knee meniscus rupture; lateral meniscus; monozygotic twins; nuclear magnetic resonance imaging; peroneal muscle; physical examination; posterior cruciate ligament reconstruction; posterior cruciate ligament rupture; quadriceps femoris muscle; return to sport; semitendinous muscle; tendon graft; visual analog scale; young adult |
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Elsevier Ltd |
22102612 |
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Article |
Q3 |
193 |
19555 |
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10 |
Amalia M.; Saputri F.C.; Sauriasari R.; Widyantoro B. |
Amalia, Muttia (57201697619); Saputri, Fadlina Chany (45561842900); Sauriasari, Rani (16246507200); Widyantoro, Bambang (35286148600) |
57201697619; 45561842900; 16246507200; 35286148600 |
Cholesterol low density lipoprotein associations with complete blood count parameters in atherosclerotic cardiovascular disease patients |
2024 |
AIP Conference Proceedings |
3155 |
1 |
030007 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85196498049&doi=10.1063%2f5.0218103&partnerID=40&md5=d5db89cbf03fdeda55e3adcd862fe364 |
Doctoral Program, Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Department of Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - National Cardiovascular Center, Harapan Kita, Jakarta, 11420, Indonesia |
Amalia M., Doctoral Program, Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Saputri F.C., Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Sauriasari R., Department of Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Widyantoro B., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - National Cardiovascular Center, Harapan Kita, Jakarta, 11420, Indonesia |
Cholesterol low density lipoprotein (LDL) is strongly associated with the development of atherosclerotic vascular disease (ASCVD). The objective of this study is to assess the relationships between cholesterol LDL and complete blood count (CBC) in ASCVD patients. This cross-sectional study was conducted at the National Cardiovascular Center Harapan Kita Jakarta. A total of 75 ASCVD patients from outpatient and emergency room departments were included in this study. The Chi-square test and the regression logistic analysis test were used to assess the relationships between cholesterol LDL and CBC. In this study, LDL level was found to be associated with the levels of leucocyte, percentage of eosinophil, percentage of lymphocyte, and absolute monocyte level. Lower eosinophil and lymphocyte levels were associated with increased LDL level. Regression logistic analysis revealed that the percentage of eosinophil (95%CI, 1.20 - 8.98; p value=0.02) and absolute monocyte (95%CI, 0.11 - 0.97; p value=0.04) were significant predictors of higher LDL levels in ASCVD. Increased inflammation due to elevated LDL may have resulted in circulating blood count alterations. Leucocytes and their differential count may aid in determining chronic inflammation and the progression of ASCVD. © 2024 Author(s). |
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American Institute of Physics |
0094243X |
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Conference paper |
- |
164 |
21059 |
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11 |
Sekarsari D.; Handoyono Q.F.; Amal M.Y.; Maharani M.A.P.; Hendriarto A. |
Sekarsari, Damayanti (57193342279); Handoyono, Quinta Febryani (58993286100); Amal, Mohamad Yanuar (57221702104); Maharani, Maria Angela Putri (58158818200); Hendriarto, Andra (57216821517) |
57193342279; 58993286100; 57221702104; 58158818200; 57216821517 |
Pediatric paraparesis: Radiological challenges in multidrug-resistant tuberculous spondylitis based on experience in Indonesia |
2024 |
Radiology Case Reports |
19 |
8 |
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3287 |
3293 |
6 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85193445919&doi=10.1016%2fj.radcr.2024.04.001&partnerID=40&md5=71f94f873b95af48e9249b2aeb5dc7ea |
Division of Pediatric Radiology, Department of Radiology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Department of Radiology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Department of Anatomic Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Department of Orthopedics and Traumatology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia |
Sekarsari D., Division of Pediatric Radiology, Department of Radiology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Handoyono Q.F., Department of Radiology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Amal M.Y., Division of Pediatric Radiology, Department of Radiology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Maharani M.A.P., Department of Anatomic Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Hendriarto A., Department of Orthopedics and Traumatology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia |
Multidrug-resistant tuberculous spondylitis is a global health issue, especially in developing nations, and non-specific symptoms lead to delay in identification, treatment, and potential disability in children. Radiology plays a crucial role in diagnosing tuberculous spondylitis, which in turn might lead to effective treatment, prevention of disability and improved patient outcomes. Our case involved a 20-month-old malnourished child presented with paraparesis, revealing a history of contact with parental multidrug-resistant tuberculosis. Multimodality radiological examinations, including conventional radiography, CT, and MRI revealed extensive disease of the spine with disc involvement, large paravertebral abscess, and kyphotic deformity which produced neurological deficits, necessitating both anti-tuberculosis regimen and surgical intervention. Radiological examinations have a pivotal role in diagnosing, evaluating and guiding timely management of multidrug-resistant tuberculous spondylitis. Prompt diagnosis of the condition is crucial in order to prevent potentially severe complications, which contribute significantly to morbidity. Our case demonstrated the importance of radiology in diagnosing extensive spine involvement of the disease causing neurological deficits. Furthermore, radiology also helps in managing tuberculous spondylitis to prevent future disability in a child patient of a developing country. This case highlights the crucial significance of radiological imaging in the diagnosis and management of pediatric tuberculous spondylitis in impoverished nations. The patient's complex medical history highlights the socioeconomic factors contributing to tuberculosis burden. Early and comprehensive radiological assessment, together with collaboration between radiologists and clinicians, is vital for timely intervention and improved outcomes in pediatric tuberculous spondylitis cases to prevent the impact of this debilitating disease on children. © 2024 |
Pediatric imaging; Tuberculosis; Tuberculous spondylitis |
abscess; Article; Babinski reflex; case report; child; clinical article; computer assisted tomography; erythrocyte sedimentation rate; female; gait; ground glass opacity; human; Indonesia; kyphosis; lung consolidation; lung fibrosis; malnutrition; multidrug resistant tuberculosis; muscle strength; neurologic examination; nuclear magnetic resonance imaging; paraplegia; physical examination; preschool child; radiodiagnosis; radiological parameters; tuberculous spondylitis |
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Elsevier Inc. |
19300433 |
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Article |
Q4 |
226 |
17897 |
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13 |
Lubis S.M.; Soesanti F.; Hidayati E.L.; Aap B.T. |
Lubis, Siska Mayasari (57199647517); Soesanti, Frida (37068080600); Hidayati, Eka Laksmi (57200542624); Aap, Bambang Tridjaja (59173556500) |
57199647517; 37068080600; 57200542624; 59173556500 |
Congenital Adrenal Hyperplasia in Children: The Relationship between Plasma Renin Activity and Hypertension |
2024 |
Iranian Journal of Medical Sciences |
49 |
6 |
|
377 |
383 |
6 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85196070765&doi=10.30476%2fijms.2023.98508.3058&partnerID=40&md5=91547d4afbbefb5cfac5f020cbce3da4 |
Department of Child Health, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Department of Child Health, Faculty of Medicine, Universitas Indonesia Jakarta, Indonesia |
Lubis S.M., Department of Child Health, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Soesanti F., Department of Child Health, Faculty of Medicine, Universitas Indonesia Jakarta, Indonesia; Hidayati E.L., Department of Child Health, Faculty of Medicine, Universitas Indonesia Jakarta, Indonesia; Aap B.T., Department of Child Health, Faculty of Medicine, Universitas Indonesia Jakarta, Indonesia |
Background: Children with Congenital Adrenal Hyperplasia (CAH) have a higher chance of hypertension. The likelihood of hypertension is higher in CAH children who get fludrocortisone medication and have an over-suppression. Plasma renin activity (PRA) is a sensitive indicator when the fludrocortisone dose is insufficient. The objective of this study is to assess the relationship between plasma renin activity with hypertension in 21-hydroxylase-deficient (21-OHD) CAH children. Methods: This cross-sectional observational analytical study was conducted in 2019 at the Pediatric Endocrinology Outpatient Clinic in Dr. Cipto Mangunkusumo Hospital (RSCM), Jakarta, Indonesia. The subjects were 21-OHD CAH children, aged >6 months to 18 years who had already taken hydrocortisone with or without fludrocortisone for at least 6 months, and were divided into hypertension and non-hypertension groups. The subjects were selected by a consecutive sampling method. Data was analyzed using SPSS software (version 23.0) with unpaired t test analysis and multiple logistic regression test. Statistical significance was achieved if P<0.05. Results: Forty 21-OHD CAH patients were included, and 20 subjects (50%) had hypertension. A higher incidence of hypertension was found in salt-wasting CAH than in simple virilizing types (59.3% vs 30.8%). There was a significant mean difference in PRA levels between hypertension and non-hypertension groups in salt-wasting patients (P=0.016). A significant difference between the last dose of hydrocortisone with the number of hypertension patients in saltwasting patients (P=0.032) was found, and low PRA levels showed a 1.09 times higher risk of hypertension. Conclusion: Children with salt-wasting CAH with low PRA levels had a higher risk of getting hypertension. © Iranian Journal of Medical Sciences. |
Adrenal hyperplasia; congenital; Hydrocortisone; Hypertension |
fludrocortisone; hydrocortisone; renin; age distribution; analytic method; Article; body mass; child; clinical article; clinical evaluation; controlled study; cross-sectional study; drug dose regimen; female; high risk population; human; hypertension; incidence; Indonesia; male; observational study; outpatient department; patient selection; plasma renin activity; salt wasting; school child; steroid 21 monooxygenase deficiency; treatment duration |
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Shiraz University of Medical Sciences |
02530716 |
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Article |
Q2 |
413 |
12184 |
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15 |
Harzif A.K.; Andyra A.F.; Sayogo A.; Ummah N.; Puspawardani A.R.; Nurbaeti P.; Wiweko B. |
Harzif, Achmad Kemal (57191493435); Andyra, Azizah Fitriayu (57438092800); Sayogo, Atikah (58945649000); Ummah, Nafi’atul (58945649100); Puspawardani, Aisyah Retno (58944793100); Nurbaeti, Putri (58945649200); Wiweko, Budi (43061741400) |
57191493435; 57438092800; 58945649000; 58945649100; 58944793100; 58945649200; 43061741400 |
Embryo response to aneuploidy through self-correction mechanism: a literature review |
2024 |
Middle East Fertility Society Journal |
29 |
1 |
16 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85188103317&doi=10.1186%2fs43043-024-00176-8&partnerID=40&md5=2ea59e3b8e555f1604df15976d449b84 |
Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Yasmin IVF Clinic Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Harzif A.K., Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Yasmin IVF Clinic Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Andyra A.F., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sayogo A., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ummah N., Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Puspawardani A.R., Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Nurbaeti P., Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wiweko B., Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Yasmin IVF Clinic Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Meiotic and mitotic errors often lead to aneuploidy and mosaicism. In this context, the self-correction mechanism enables the embryo to preferentially retain and preserve euploid cells through processes such as apoptosis, necrosis, or marginalization. This mechanism is thought to minimize the chance of genetic abnormalities during cell development. Materials and methods: A literature search for articles written in English from January 2013 to October 2023 was conducted on PubMed, EBSCO, and Scopus, using the keywords “self-correction,” “self-repair,” “aneuploidy,” “mosaicism,” and “embryo.” Results: A total of 308 articles were collected, out of which 5 retrospective and 1 prospective study were selected based on inclusion criteria. Discussions: Investigations showed that embryos remove chromosomally abnormal cells, supporting the self-correction mechanism. aCGH has been used in 4 studies to demonstrate the presence of self-correction in mosaic embryos. Furthermore, a higher relative viability of polyploidies than complex aneuploidies was observed, suggesting early discrimination against complex aneuploidy, particularly those arising from mitotic origins. However, there are doubts about the reliability of preimplantation genetic testing for aneuploidy at the blastocyst stage, as it may lead to a high rate of false positives and the discarding of "good" embryos. Conclusions: Studies showed a self-correction mechanism in human embryos through the ability to expel abnormal cells. Further investigation is needed to elucidate the underlying mechanisms and determine optimal strategies for preimplantation genetic testing to fully understand and optimize the use of self-correction mechanisms in embryo assessment and selection. © The Author(s) 2024. |
Aneuploidy; Embryo; Mosaicism; Self-correction; Self-repair |
aneuploidy; blastocyst; blastomere; chromosome 19; chromosome aberration; comparative genomic hybridization; cytogenetic analysis; embryo; embryo (anatomy); embryo biopsy; embryo development; false positive result; high throughput sequencing; human; human embryo; mosaicism; polymerase chain reaction; polyploidy; preimplantation genetic screening; Review; single nucleotide polymorphism array; trophectoderm; uniparental disomy; X chromosome |
Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia |
The authors would like to express gratitude to the Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, for supporting this study. |
Springer Science and Business Media Deutschland GmbH |
11105690 |
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Review |
Q3 |
322 |
14459 |
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16 |
Prawiroharjo P.; Anggraini H.; Geraldi I.P.; Octaviana F.; Budikayanti A.; Safri A.Y.; Wiratman W.; Indrawati L.A.; Fadli N.; Harsono A.R.; Hakim M. |
Prawiroharjo, Pukovisa (57195838668); Anggraini, Hikma (59124155100); Geraldi, Iskandar Purba (58116732300); Octaviana, Fitri (26029958700); Budikayanti, Astri (57194713932); Safri, Ahmad Yanuar (57091699300); Wiratman, Winnugroho (57191920526); Indrawati, Luh Ari (57205117182); Fadli, Nurul (58772486600); Harsono, Adrian Ridski (59011489600); Hakim, Manfaluthy (57216861859) |
57195838668; 59124155100; 58116732300; 26029958700; 57194713932; 57091699300; 57191920526; 57205117182; 58772486600; 59011489600; 57216861859 |
Factors correlating to decisions for prescribing pharmacological treatment and referrals in suspected peripheral neuropathy cases in chat consultation-based application |
2024 |
Heliyon |
10 |
10 |
e30713 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85192934441&doi=10.1016%2fj.heliyon.2024.e30713&partnerID=40&md5=8df51869c2fab92bbe63df29c1ff5e0a |
Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia; Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia; Department of Neurology, Universitas Indonesia Hospital, Indonesia |
Prawiroharjo P., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia, Department of Neurology, Universitas Indonesia Hospital, Indonesia; Anggraini H., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia; Geraldi I.P., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia; Octaviana F., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia; Budikayanti A., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia; Safri A.Y., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia; Wiratman W., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia, Department of Neurology, Universitas Indonesia Hospital, Indonesia; Indrawati L.A., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia; Fadli N., Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia, Department of Neurology, Universitas Indonesia Hospital, Indonesia; Harsono A.R., Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia, Department of Neurology, Universitas Indonesia Hospital, Indonesia; Hakim M., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Staff, Department of Neurology, Dr Cipto Mangunkusumo Hospital, Indonesia |
Introduction: Since the COVID-19 pandemic, there has been increasing use ofchat-based telemedicine, including for patients with neuropathy complaints. It is imperative to learn how to effectively use telemedicine. This study describes the characteristics of patients with neuropathy complaints in chat-based telemedicine services in Indonesia and their influence on treatment decisions and referrals. Methods: This is a retrospective cross-sectional study during the COVID-19 pandemic era (March 2020 to December 2021) using anonymous secondary data from patient chat databases on Indonesian application-based telemedicine services (Halodoc, Alodokter, Good Doctor, and Milvik). We applied bivariate and multivariate analysis. Results: We obtained 1051 patients with suspected peripheral nerve complaints (4 per 10,000) from a total of 2,199,527 user consultations, with the majority being 40–64 years old females and diabetes mellitus was the leading comorbid (90.7%). Most patients received treatment (90.7%) and only 11.4% patients were referred. Multivariate analysis showed that treatment was more likely to be given by a neurologist (p < 0.01). Chronic symptoms (p < 0.01) and previous laboratory/other tests (p = 0.01) decreased the likelihood of medication prescription. Referrals were more likely to be given to chronic onset (p = 0.02), hypertension and heart disease (p < 0.01), and previous laboratory/other tests (p = 0.02). The opposite was true for age≥65 years, female (p = 0.04), and neurologists or other specialists as responders (p < 0.01). Conclusion: We identified several factors that influence the treatment decision such as female patients and onset. Meanwhile, age, sex, chronic symptoms, history of hypertension and heart disease, and previous laboratory/other tests may influence the referral decisions. General practitioners were more likely to refer the patients whereas neurologists or other specialists were more likely to give treatment. Chat-based telemedicine services can still be developed in the future to be better. © 2024 |
Chat; Clinical decision making; Neuropathic pain; Neuropathy complaints; Paresthesia; Telemedicine |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
609 |
8422 |
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