Publikasi Scopus 2023 per tanggal 31 Oktober 2023 (754 artikel)

Ioannidis L.J.; Studniberg S.I.; Eriksson E.M.; Suwarto S.; Denis D.; Liao Y.; Shi W.; Garnham A.L.; Sasmono R.T.; Hansen D.S.
43861389400; 57219659354; 24831572400; 8443626100; 57196097492; 55756054100; 56420990900; 57040848000; 6506482032; 7202786472
Integrated systems immunology approach identifies impaired effector T cell memory responses as a feature of progression to severe dengue fever
2023
Journal of Biomedical Science
30
1
24
0
The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia; Division of Tropical and Infectious Diseases, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Hospital (RSCM), Jakarta, Indonesia; Eijkman Research Center for Molecular Biology, Jakarta, Indonesia; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, Australia; School of Mathematics and Statistics, The University of Melbourne, Parkville, VIC, Australia; Department of Microbiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia
Ioannidis L.J., The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia, Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia; Studniberg S.I., The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia, Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia; Eriksson E.M., The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia, Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia; Suwarto S., Division of Tropical and Infectious Diseases, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Hospital (RSCM), Jakarta, Indonesia; Denis D., Eijkman Research Center for Molecular Biology, Jakarta, Indonesia; Liao Y., Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, Australia; Shi W., Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, Australia; Garnham A.L., The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia, School of Mathematics and Statistics, The University of Melbourne, Parkville, VIC, Australia; Sasmono R.T., Eijkman Research Center for Molecular Biology, Jakarta, Indonesia; Hansen D.S., Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia, Department of Microbiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia
Background: Typical symptoms of uncomplicated dengue fever (DF) include headache, muscle pains, rash, cough, and vomiting. A proportion of cases progress to severe dengue hemorrhagic fever (DHF), associated with increased vascular permeability, thrombocytopenia, and hemorrhages. Progression to severe dengue is difficult to diagnose at the onset of fever, which complicates patient triage, posing a socio-economic burden on health systems. Methods: To identify parameters associated with protection and susceptibility to DHF, we pursued a systems immunology approach integrating plasma chemokine profiling, high-dimensional mass cytometry and peripheral blood mononuclear cell (PBMC) transcriptomic analysis at the onset of fever in a prospective study conducted in Indonesia. Results: After a secondary infection, progression to uncomplicated dengue featured transcriptional profiles associated with increased cell proliferation and metabolism, and an expansion of ICOS+CD4+ and CD8+ effector memory T cells. These responses were virtually absent in cases progressing to severe DHF, that instead mounted an innate-like response, characterised by inflammatory transcriptional profiles, high circulating levels of inflammatory chemokines and with high frequencies of CD4low non-classical monocytes predicting increased odds of severe disease. Conclusions: Our results suggests that effector memory T cell activation might play an important role ameliorating severe disease symptoms during a secondary dengue infection, and in the absence of that response, a strong innate inflammatory response is required to control viral replication. Our research also identified discrete cell populations predicting increased odds of severe disease, with potential diagnostic value. © 2023, The Author(s).
Dengue fever; Dengue hemorrhagic fever; Effector memory T cells; Non-classical monocytes
Dengue; Humans; Leukocytes, Mononuclear; Prospective Studies; Severe Dengue; T-Lymphocytes; CD4 antigen; CD8 antigen; chemokine receptor CCR6; chemokine receptor CCR7; chemokine receptor CXCR3; chemokine receptor CXCR5; CXCL11 chemokine; CXCL9 chemokine; epithelial derived neutrophil activating factor 78; gamma interferon inducible protein 10; interleukin 8; monocyte chemotactic protein 1; thymus and activation regulated chemokine; adolescent; adult; aerobic metabolism; Article; cell division; cell metabolism; cell proliferation; clinical article; cohort analysis; controlled study; dengue; dengue hemorrhagic fever; Dengue virus 1; Dengue virus 2; Dengue virus 3; Dengue virus 4; disease exacerbation; disease severity; effector cell; human; human cell; immune response; Indonesia; infection r
Australian Government National Health and Medical Research Council; DSH; Ministry of Research and Technology of the Republic of Indonesia; National Health and Medical Research Council, NHMRC, (200466); Australian Academy of Science; State Government of Victoria
This work was performed in part at the Materials Characterisation and Fabrication Platform (MCFP) at the University of Melbourne and the Victorian Node of the Australian National Fabrication Facility (ANFF). Supported by the Australian Government National Health and Medical Research Council (NHMRC) Independent Medical Research Institutes Infrastructure Support Scheme and e-Asia Grant 200466; the A
BioMed Central Ltd
10217770
37055751
Article
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2520
866