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Sudjono C.; Quinncilla K.H.; Qonita M.; Wijaya N.J.; Kurnain D. |
Sudjono, Clinton (59196697600); Quinncilla, Kiara Hanna (59136515900); Qonita, Ms (59195443000); Wijaya, Nicholas Jason (58483356100); Kurnain, Dave (59196070600) |
59196697600; 59136515900; 59195443000; 58483356100; 59196070600 |
Early Menarche as a Protective Factor Against Cardiovascular Events: A Systematic Review and Meta-analysis |
2024 |
Anatolian journal of cardiology |
28 |
7 |
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329 |
338 |
9 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85197189251&doi=10.14744%2fAnatolJCardiol.2024.3996&partnerID=40&md5=fcfbfda7ab7b31922e8582c997fc0e7a |
Department of Cardiology, Faculty of Medicine, Tarumanagara University, Jakarta, Indonesia; Sebelas Maret University, Surakarta, Indonesia; Jenderal Soedirman University, Purwokerto, Indonesia; Undergraduate Medical Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Sudjono C., Department of Cardiology, Faculty of Medicine, Tarumanagara University, Jakarta, Indonesia; Quinncilla K.H., Sebelas Maret University, Surakarta, Indonesia; Qonita M., Jenderal Soedirman University, Purwokerto, Indonesia; Wijaya N.J., Undergraduate Medical Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kurnain D., Department of Cardiology, Faculty of Medicine, Tarumanagara University, Jakarta, Indonesia |
BACKGROUND: Women are often neglected in cardiovascular health prevention. Age at menarche (AAM) has been linked to cardiovascular (CVD) disease in women and is potentially identified as one of the significant CVD risk factor. However, there is still limited comprehensive evidence addressing this issue. This systematic review and meta-analysis aimed to investigate how early menarche affects the outcome of all-cause mortality, CVD mortality, total cardiovascular disease event, stroke (ischemic, hemorrhagic, and total stroke), and coronary heart disease (CHD). METHOD: The Cochrane Library, MEDLINE, Embase, ScienceDirect, and Google Scholar databases were searched from March 2013 to March 2023 for cohorts investigating the effect of early onset of menarche on CVD events with a minimum follow-up period of 5 years. Studies that observed specific population and/or included women with a history of CVD at baseline were excluded. The Newcastle-Ottawa scale was used for risk of bias assessment for each cohort included. The data were presented as dichotomous measure using risk ratios. I2 statistics were utilized to evaluate the heterogeneity of presented data. RESULTS: Thirteen cohorts included 18 626 799 female patients with ages ranging from 43 to 62.6 years. These reported 6 estimates each for CHD (5 483 298 patients) and all-cause mortality (1 595 878 patients), 5 estimates each for total stroke (2 941 321 patients) and CVD mortality (1 706 742 patients), 4 estimates each for total CVD events (3 988 311 patients) and ischemic stroke (2 434 580 patients), and 1 estimate for hemorrhagic stroke (66 104 patients). Our study found that events of CHD were significantly lower in early menarche (RR 0.57; 95% CI 0.41-0.78; P <.00001), as well as total stroke (RR 0.51; 95% CI 0.35-0.73; P =.0003), CVD mortality (RR 0.47; 95% CI 0.22-0.98; P =.04), total CVD events (RR 0.44; 95% CI 0.25-0.76; P =.003), ischemic stroke (RR 0.31; 95% CI 0.15-0.61; P <.0008), and hemorrhagic stroke (RR 0.12; 95% CI 0.07-0.20; P <.00001); and insignificantly higher in all-cause mortality (RR 0.90, 95% CI 0.76-1.06, P =.20). CONCLUSION: In our study, cardiovascular events are lower in women with early menarche; hence, the later age of menarche is a potential risk factor to be considered when assessing CVD risk in a patient. However, our sample characteristics were heterogenous, and we did not consider other female hormonal factors that might potentially contribute to the CVD outcomes observed; thus, further studies are needed to clarify. |
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Age Factors; Cardiovascular Diseases; Female; Humans; Menarche; Middle Aged; Protective Factors; Risk Factors; age; cardiovascular disease; female; human; menarche; meta analysis; middle aged; mortality; prevention and control; protection; risk factor |
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21492271 |
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38940409 |
Article |
Q3 |
290 |
15434 |
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6 |
Pangaribuan F.D.; Ham M.F.; Mutmainnah M.; Harahap A.S. |
Pangaribuan, Flora Dameria (59208908500); Ham, Maria Francisca (7004830001); Mutmainnah, Mutiah (58296414300); Harahap, Agnes Stephanie (57218511857) |
59208908500; 7004830001; 58296414300; 57218511857 |
Cytotoxic T-lymphocyte-associated 4 protein expression is associated with a high international prognostic score in advanced-stage classical Hodgkin lymphoma |
2024 |
BMC Research Notes |
17 |
1 |
190 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85197781046&doi=10.1186%2fs13104-024-06853-1&partnerID=40&md5=dad504884f7d240c83610069b5b74ae6 |
Anatomical Pathology Department, Persahabatan Hospital, Jakarta, 13230, Indonesia; Anatomical Pathology Department, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia; Faculty of Medicine Universitas Indonesia, Human Cancer Research Center-Indonesian Medical Education and Research Institute, Jakarta, 10430, Indonesia; Faculty of Medicine, Universitas Muhammadiyah Palembang, Palembang, 30263, Indonesia |
Pangaribuan F.D., Anatomical Pathology Department, Persahabatan Hospital, Jakarta, 13230, Indonesia; Ham M.F., Anatomical Pathology Department, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia, Faculty of Medicine Universitas Indonesia, Human Cancer Research Center-Indonesian Medical Education and Research Institute, Jakarta, 10430, Indonesia; Mutmainnah M., Faculty of Medicine, Universitas Muhammadiyah Palembang, Palembang, 30263, Indonesia; Harahap A.S., Anatomical Pathology Department, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia, Faculty of Medicine Universitas Indonesia, Human Cancer Research Center-Indonesian Medical Education and Research Institute, Jakarta, 10430, Indonesia |
Objective: Twenty percent of all classical Hodgkin lymphoma (CHL) cases relapse and recur, especially in advanced stages with a high International Prognostic Score (IPS). Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a regulatory molecule that can inhibit the immune response and is related to tumor aggressiveness. This study aimed to determine the relationship between CTLA-4 expression in advanced-stage CHL and IPS, identifying it as a potential therapy target. Results: In advanced-stage CHL, the group with a high IPS exhibited significantly higher mean CTLA-4 expression compared to the group with a low IPS (p = 0.003).The group with Hb level < 10.5 g/dl, leukocyte count > 15,000/µL, lymphocyte count < 8%, albumin level < 4 g/dl, and stage 4 exhibited higher CTLA-4 expression than the other group, although only leukocyte count and stage showed statistical significance (p = 0.004 and p = 0.020). Mean CTLA-4 expression was 239.84 ± 76.36 for nodular sclerosis, 293.95 ± 147.94 for mixed cellularity, 271.4 ± 23.56 for lymphocyte depleted, and 225.2 for lymphocyte-rich subtypes. The results suggest that CTLA-4 expression is associated with adverse prognostic factors in the IPS for advanced-stage CHL, supporting the notion that immune checkpoints play a role in cancer progression. © The Author(s) 2024. |
Advanced-stage; Cytotoxic T-lymphocyte-associated protein 4; Hodgkin lymphoma; International prognostic score |
Adolescent; Adult; Aged; Biomarkers, Tumor; CTLA-4 Antigen; Female; Hodgkin Disease; Humans; Male; Middle Aged; Neoplasm Staging; Prognosis; Young Adult; CTLA4 protein, human; cytotoxic T lymphocyte antigen 4; tumor marker; adolescent; adult; aged; cancer staging; female; genetics; Hodgkin disease; human; immunology; male; metabolism; middle aged; pathology; prognosis; young adult |
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BioMed Central Ltd |
17560500 |
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38978137 |
Article |
Q2 |
534 |
9718 |
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7 |
Fedrizal F.F.; Wijaya I.P.; Abdullah M.; Yamin M. |
Fedrizal, Fenandri Fadillah (57219280233); Wijaya, Ika Prasetya (57193731572); Abdullah, Murdani (7103393434); Yamin, Muhammad (23475706300) |
57219280233; 57193731572; 7103393434; 23475706300 |
Elevated neutrophyl-to-lymphocyte ratioand smoking are associated with chronic total occlusion in patients with ST elevation myocardial infarction |
2024 |
BMC Cardiovascular Disorders |
24 |
1 |
12 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85181244917&doi=10.1186%2fs12872-023-03680-3&partnerID=40&md5=9aaf3c2915cdc2583c57f09d4d1e5b80 |
Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Unit Epidemiology, Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Fedrizal F.F., Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Wijaya I.P., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Abdullah M., Unit Epidemiology, Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Yamin M., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Background: Atherosclerosis is a progressive disease characterized by the build-up of lipids and connective tissue in the large arteries. Some patients experience chronic total occlusion (CTO). Inflammation plays a key role in the development and complications of atherosclerosis. Neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation associated with the development of acute coronary syndrome (ACS). We aimed to assess the relationship between NLR and CTO in ACS patients with ST elevated myocardial infarction (STEMI) in Indonesia. Methods: This cross-sectional study was performed with secondary data obtained from patient medical records at Cipto Mangunkusumo National Central Hospital, Jakarta. Inclusion criteria were patients with ACS and STEMI who underwent coronary angiography in 2015–2018. Results: A total of 98 patients were enrolled in the analysis. Most subjects with CTO were male, elderly (> 60), smoking, had no history of diabetes mellitus (DM) or hypertension, no family history of coronary heart disease (CHD), but had a history of ACS and had never consumed statin or antiplatelet medications. Bivariate logistic regression analysis revealed that male gender (PR = 1.820; 95%CI 0.871–3.805; p = 0.025) and smoking (PR = 1.781; 95%CI 1.028–3.086; p = 0.004) were significantly correlated with CTO. Receiver operator characteristic (ROC) curve revealed that higher NLR (≥ 6.42) could predict a CTO diagnosis with positive predictive value (PPV) of 91%. Multivariate analysis revealed that NLR was correlated with an 11.2-fold increase in occurrence of CTO (95%CI 3.250-38.303; p < 0.001). Additionally, smoking was correlated with a 7-fold increase in CTO (95% CI 1.791–30.508; p = 0.006). Conclusion: NLR value of ≥ 6.42 is potentially useful as a marker of CTO in STEMI patients. In addition, smoking increases the risk of CTO in ACS/STEMI patients. © 2023, The Author(s). |
Chronic total occlusion; Coronary angiography; Coronary artery Disease; Myocardial Infarction; Neutrophil-to-lymphocyte ratio |
Acute Coronary Syndrome; Aged; Atherosclerosis; Chronic Disease; Coronary Occlusion; Cross-Sectional Studies; Female; Humans; Inflammation; Lymphocytes; Male; Percutaneous Coronary Intervention; Smoking; ST Elevation Myocardial Infarction; Treatment Outcome; antithrombocytic agent; hydroxymethylglutaryl coenzyme A reductase inhibitor; acute coronary syndrome; adult; age; aged; Article; bivariate analysis; cardiovascular risk; chronic total occlusion; controlled study; coronary angiography; cross-sectional study; diabetes mellitus; diagnostic test accuracy study; disease association; female; human; hypertension; Indonesia; ischemic heart disease; logistic regression analysis; major clinical study; male; medical record; multivariate analysis; neutrophil lymphocyte ratio; predictive value; re |
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BioMed Central Ltd |
14712261 |
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38172732 |
Article |
Q2 |
601 |
8561 |
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8 |
Sekarsari D.; Handoyono Q.F.; Amal M.Y.; Maharani M.A.P.; Hendriarto A. |
Sekarsari, Damayanti (57193342279); Handoyono, Quinta Febryani (58993286100); Amal, Mohamad Yanuar (57221702104); Maharani, Maria Angela Putri (58158818200); Hendriarto, Andra (57216821517) |
57193342279; 58993286100; 57221702104; 58158818200; 57216821517 |
Pediatric paraparesis: Radiological challenges in multidrug-resistant tuberculous spondylitis based on experience in Indonesia |
2024 |
Radiology Case Reports |
19 |
8 |
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3287 |
3293 |
6 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85193445919&doi=10.1016%2fj.radcr.2024.04.001&partnerID=40&md5=71f94f873b95af48e9249b2aeb5dc7ea |
Division of Pediatric Radiology, Department of Radiology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Department of Radiology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Department of Anatomic Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Department of Orthopedics and Traumatology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia |
Sekarsari D., Division of Pediatric Radiology, Department of Radiology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Handoyono Q.F., Department of Radiology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Amal M.Y., Division of Pediatric Radiology, Department of Radiology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Maharani M.A.P., Department of Anatomic Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Hendriarto A., Department of Orthopedics and Traumatology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia |
Multidrug-resistant tuberculous spondylitis is a global health issue, especially in developing nations, and non-specific symptoms lead to delay in identification, treatment, and potential disability in children. Radiology plays a crucial role in diagnosing tuberculous spondylitis, which in turn might lead to effective treatment, prevention of disability and improved patient outcomes. Our case involved a 20-month-old malnourished child presented with paraparesis, revealing a history of contact with parental multidrug-resistant tuberculosis. Multimodality radiological examinations, including conventional radiography, CT, and MRI revealed extensive disease of the spine with disc involvement, large paravertebral abscess, and kyphotic deformity which produced neurological deficits, necessitating both anti-tuberculosis regimen and surgical intervention. Radiological examinations have a pivotal role in diagnosing, evaluating and guiding timely management of multidrug-resistant tuberculous spondylitis. Prompt diagnosis of the condition is crucial in order to prevent potentially severe complications, which contribute significantly to morbidity. Our case demonstrated the importance of radiology in diagnosing extensive spine involvement of the disease causing neurological deficits. Furthermore, radiology also helps in managing tuberculous spondylitis to prevent future disability in a child patient of a developing country. This case highlights the crucial significance of radiological imaging in the diagnosis and management of pediatric tuberculous spondylitis in impoverished nations. The patient's complex medical history highlights the socioeconomic factors contributing to tuberculosis burden. Early and comprehensive radiological assessment, together with collaboration between radiologists and clinicians, is vital for timely intervention and improved outcomes in pediatric tuberculous spondylitis cases to prevent the impact of this debilitating disease on children. © 2024 |
Pediatric imaging; Tuberculosis; Tuberculous spondylitis |
abscess; Article; Babinski reflex; case report; child; clinical article; computer assisted tomography; erythrocyte sedimentation rate; female; gait; ground glass opacity; human; Indonesia; kyphosis; lung consolidation; lung fibrosis; malnutrition; multidrug resistant tuberculosis; muscle strength; neurologic examination; nuclear magnetic resonance imaging; paraplegia; physical examination; preschool child; radiodiagnosis; radiological parameters; tuberculous spondylitis |
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Elsevier Inc. |
19300433 |
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Article |
Q4 |
226 |
17897 |
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10 |
Atmodiwirjo P.; Bangun K.; Rachadian Ramadan M.; Tania V.; Djohan M.; Ralena N.A.; Amanda N.F. |
Atmodiwirjo, Parintosa (57203016968); Bangun, Kristaninta (36902624600); Rachadian Ramadan, Mohamad (57222667572); Tania, Vika (57394760300); Djohan, Michael (59205590300); Ralena, Nadhira Anindita (57214093149); Amanda, Nadira Fildza (59205390500) |
57203016968; 36902624600; 57222667572; 57394760300; 59205590300; 57214093149; 59205390500 |
Does Free Fibular Flap Reconstruction Affect the Quality of Life in Pediatric Patients with Various Extend of Mandible Defects? |
2024 |
Journal of Craniofacial Surgery |
35 |
5 |
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1411 |
1416 |
5 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85197653880&doi=10.1097%2fSCS.0000000000010347&partnerID=40&md5=95fd58446d12f8870a0550e28ee2edd3 |
Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Indonesia; Reconstructive Microsurgery and Oncoplasty Section, Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Dr. Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Cleft and Craniofacial Centre, Dr. Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Atmodiwirjo P., Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Indonesia, Reconstructive Microsurgery and Oncoplasty Section, Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Dr. Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Bangun K., Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Indonesia, Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Cleft and Craniofacial Centre, Dr. Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rachadian Ramadan M., Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Indonesia, Reconstructive Microsurgery and Oncoplasty Section, Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Dr. Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Tania V., Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Indonesia, Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Cleft and Craniofacial Centre, Dr. Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Djohan M., Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Indonesia; Ralena N.A., Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Indonesia; Amanda N.F., Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Indonesia |
Background: The long-term outcomes in pediatric patients with various extents of mandible defects have not been well-documented. Methods: A retrospective case series in which this study looked at pediatric patients under the age of 13 who had mandibular reconstruction with free fibular flap and had not received another operation in the previous 6 months. The eating, swallowing, speech function, and quality of life are evaluated with EORTC QLQ-H&N35 after the mandible growth spurt has occurred. Results: A total of 7 patients were included in this study with operation ages ranging from 6 years 1 month to 12 years 2 months. The etiology of malignant tumors was found in 2 patients and benign tumors in 5 patients. The mandibular defect distribution consists of 1 class Ic, 1 class II, 2 class IIc, 2 class III, and 1 class IVc. All patients reported no swallowing or speech difficulties. However, transient eating trouble was seen in 1 patient due to the extensive defect size that causes tooth loss. Only 1 patient received dental rehabilitation. The patients displayed an overall good quality of life with an average score of 2.857. Conclusions: Free fibular flap for mandibular reconstruction in children who have not reached their mandibular growth peak have a satisfying outcome, both in their function and quality of life. © 2024 Lippincott Williams and Wilkins. All rights reserved. |
Fibular flap; mandible; pediatric; quality of life; reconstruction |
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Lippincott Williams and Wilkins |
10492275 |
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Article |
Q2 |
396 |
12572 |
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16 |
Lazarus G.; Putra I.G.N.S.; Junaidi M.C.; Oswari J.S.; Oswari H. |
Lazarus, Glen (57927339800); Putra, I Gusti Ngurah Sanjaya (57217596461); Junaidi, Michelle Clarissa (57974344300); Oswari, Jessica Sylvania (58891104500); Oswari, Hanifah (12777323800) |
57927339800; 57217596461; 57974344300; 58891104500; 12777323800 |
The relationship of vitamin D deficiency and childhood diarrhea: a systematic review and meta-analysis |
2024 |
BMC Pediatrics |
24 |
1 |
125 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85185277894&doi=10.1186%2fs12887-024-04599-0&partnerID=40&md5=85b6f5889cf8440100e00f5e95243139 |
Department of Child Health, Gastrohepatology Division, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Child Health, Gastroenterology and Hepatology Division, Medical School, Universitas Udayana, Bali, Indonesia |
Lazarus G., Department of Child Health, Gastrohepatology Division, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Putra I.G.N.S., Department of Child Health, Gastroenterology and Hepatology Division, Medical School, Universitas Udayana, Bali, Indonesia; Junaidi M.C., Department of Child Health, Gastrohepatology Division, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Oswari J.S., Department of Child Health, Gastrohepatology Division, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Oswari H., Department of Child Health, Gastrohepatology Division, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Introduction: Vitamin D deficiency may increase the risk of childhood diarrhea. We aim to carry out a review and meta-analysis of the evidence relating vitamin D insufficiency to childhood diarrhea. Methods: We searched PubMed, Ovid, Scopus, and Cochrane Library (from inception to August 2022), then independently reviewed the eligibility, and read full-text reviews for selected articles. Keywords used were ‘vitamin D’, ’25-hydroxyvitamin D’, ‘vitamin D deficiency’, ‘diarrhea’, ‘gastroenteritis’, ‘children’, and ‘pediatric’. The search was limited to studies only in English and with available full-text. Year limitation was not applied in our search. Unpublished trials, dissertations, preliminary reports, conference abstracts, and repositories were excluded from the study. Newcastle-Ottawa Scale was used as the risk of bias assessment tool. Meta-analysis using the random-effects model was done. Results: Out of 5,565 articles, 12 articles were included in our systematic review, however only 7 articles were eligible for meta-analysis. Meta-analysis showed a statistically significant association between vitamin D deficiency and diarrhea in children in developing countries (OR = 1.79; 95% CI = 1.15 to 2.80; p = 0.01). On the secondary outcome, the association of vitamin D deficiency and duration or recurrences of diarrhea are conflicting. Conclusions: There is an association between vitamin D deficiency and the prevalence of diarrhea. Future studies should evaluate the causal association, the impact of vitamin D deficiency on the severity of diarrhea, and whether vitamin D deficiency treatments affects the prevalence of diarrhea. © The Author(s) 2024. |
Childhood diarrhea; Pediatric; Vitamin D deficiency |
Child; Diarrhea; Gastroenteritis; Humans; Prevalence; Vitamin D; Vitamin D Deficiency; Vitamins; 25 hydroxyvitamin D; vitamin D; vitamin; vitamin D; age distribution; Article; chemiluminescence immunoassay; diarrhea; disease association; disease duration; disease severity; enzyme linked immunosorbent assay; evidence based medicine; gastroenteritis; human; meta analysis; Newcastle-Ottawa scale; outcome assessment; pediatric patient; prevalence; recurrence risk; systematic review; vitamin blood level; vitamin D deficiency; child; complication; diarrhea; gastroenteritis; vitamin D deficiency |
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BioMed Central Ltd |
14712431 |
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38365626 |
Article |
Q1 |
742 |
6590 |
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18 |
Mahfuz M.A.; Bramono I.A.; Rahman F.; Iriani D.; Harahap E.U.; Santoso R.B. |
Mahfuz, Muhammad Ainul (59073426400); Bramono, Ikhlas Arief (57191056767); Rahman, Fakhri (57194287568); Iriani, Dewi (59076552700); Harahap, Edward Usfie (57222296409); Santoso, Rachmat Budi (58715104300) |
59073426400; 57191056767; 57194287568; 59076552700; 57222296409; 58715104300 |
Laparoscopic Enucleation of an Extravesical Bladder Leiomyoma: A Case Report |
2024 |
African Journal of Urology |
30 |
1 |
25 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85192483652&doi=10.1186%2fs12301-024-00426-1&partnerID=40&md5=7f93ad7d489ff4bf54cab3b55523d42e |
Department of Urology, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo General Hospital, Jalan Pangeran Diponegoro No.71, Kenari, Jakarta Pusat, DKI Jakarta, Jakarta, 10430, Indonesia; Department of Urology, National Cancer Center – Dharmais Cancer Hospital, Jakarta, Indonesia; Department of Anatomical Pathology, National Cancer Center – Dharmais Cancer Hospital, Jakarta, Indonesia |
Mahfuz M.A., Department of Urology, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo General Hospital, Jalan Pangeran Diponegoro No.71, Kenari, Jakarta Pusat, DKI Jakarta, Jakarta, 10430, Indonesia; Bramono I.A., Department of Urology, National Cancer Center – Dharmais Cancer Hospital, Jakarta, Indonesia; Rahman F., Department of Urology, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo General Hospital, Jalan Pangeran Diponegoro No.71, Kenari, Jakarta Pusat, DKI Jakarta, Jakarta, 10430, Indonesia; Iriani D., Department of Anatomical Pathology, National Cancer Center – Dharmais Cancer Hospital, Jakarta, Indonesia; Harahap E.U., Department of Urology, National Cancer Center – Dharmais Cancer Hospital, Jakarta, Indonesia; Santoso R.B., Department of Urology, National Cancer Center – Dharmais Cancer Hospital, Jakarta, Indonesia |
Background: The management of leiomyomas, the most common benign mesenchymal tumours, remains highly debated. This case report presents the first laparoscopic enucleation of an extravesical bladder leiomyoma in Indonesia. Case presentation: A 48-year-old man presented with a lower abdominal mass. An abdominopelvic computed tomography scan showed a solid tumour mass in the right anterolateral wall of the bladder. To excise the mass, it was planned for the patient to undergo laparoscopic enucleation. The mass was removed intact, and a frozen section was taken to determine the malignancy profile. Histopathological examinations, followed by immunohistochemical examinations, confirmed the diagnosis of leiomyoma. Conclusions: Laparoscopic enucleation is a promising option for managing bladder masses. It is a minimally invasive procedure with optimal results for preserving bladder function. Prior to the surgery, imaging studies and cystoscopy examination are mandatory. © The Author(s) 2024. |
Extravesical bladder; Laparoscopic enucleation; Leiomyoma |
desmin (protein); eosin; hematoxylin; Ki 67 antigen; smooth muscle actin; vimentin; abdominal mass; adult; Article; bladder leiomyoma; bladder muscle; bladder wall; case report; cell proliferation; clinical article; computer assisted tomography; enucleation; extravesical bladder leiomyoma; frozen section; histopathology; human; human tissue; immunohistochemistry; laparoscopic surgery; lithotomy position; male; middle aged; peritoneum; solid malignant neoplasm; urachus |
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Springer Science and Business Media Deutschland GmbH |
11105704 |
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Article |
Q3 |
185 |
19959 |
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21 |
Manurung M.A.; Umbas R.; Hamid A.R.A.H.; Mochtar C.A. |
Manurung, Mega Anara (58293043000); Umbas, Rainy (6602634832); Hamid, Agus Rizal A. H. (57202054669); Mochtar, Chaidir Arif (6506558321) |
58293043000; 6602634832; 57202054669; 6506558321 |
Penile carcinoma: A retrospective analysis of 93 patients at a tertiary care center in Jakarta, Indonesia |
2024 |
International Journal of Urology |
31 |
7 |
|
764 |
770 |
6 |
2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85190892282&doi=10.1111%2fiju.15462&partnerID=40&md5=5701ee106fc9c117e0f66595713264e8 |
Department of Urology, Faculty of Medicine/Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Manurung M.A., Department of Urology, Faculty of Medicine/Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Umbas R., Department of Urology, Faculty of Medicine/Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Hamid A.R.A.H., Department of Urology, Faculty of Medicine/Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Mochtar C.A., Department of Urology, Faculty of Medicine/Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Objectives: Penile carcinoma (PC) is a rare disease with considerable physical and psychological impact. To date, there is no data regarding PC prevalence and characteristics in Indonesia. This study aimed to analyze the characteristics of patients with PC in Indonesia and determine cumulative survival rates and time to disease progression. Methods: This was a retrospective study of all patients diagnosed with PC at Cipto Mangunkusumo General Hospital from 1995 to 2014, with a minimum of 1 year follow-up. The outcomes of the study were cumulative survival rates and time-to-disease progression. Results: Ninety-three subjects were recruited, with a mean age of 49.44 ± 13.62. Inguinal lymph node dissection (ILND) was performed in 49 (53%) patients. The mean survival in the ILND group was better compared to the non-ILND group (80.7 months vs. 67.1 months; p = 0.032). Time-to-progression in the ILND group was significantly longer than in the non-ILND group (71.7 months vs. 54.3 months; p = 0.022). No significant difference in survival between the total and partial penectomy (PP) groups was observed (p = 0.701). Time-to-progression in total penectomy (TP) was significantly longer than in PP (68 months vs. 56.0 months; p = 0.023). In Cox-regression analysis, after adjustment of other variables, history of ILND, higher stage of cancer, and older age were found to affect the survival of patients. Conclusion: ILND in PC led to better survival and reduced disease progression. The type of penectomy is only associated with progression but not survival. TP had a longer time to disease progression compared to PP. © 2024 The Japanese Urological Association. |
inguinal lymph node dissection; penectomy; penile cancer; the survival rate; time to disease progression |
Adult; Aged; Carcinoma, Squamous Cell; Disease Progression; Follow-Up Studies; Humans; Indonesia; Lymph Node Excision; Male; Middle Aged; Penile Neoplasms; Retrospective Studies; Survival Rate; Tertiary Care Centers; adult; Article; cancer growth; cancer surgery; controlled study; follow up; histopathology; human; human tissue; Indonesia; inguinal lymph node; lymph node dissection; major clinical study; male; penis amputation; penis carcinoma; proportional hazards model; retrospective study; risk factor; surgical margin; survival analysis; survival rate; survival time; tertiary care center; aged; disease exacerbation; epidemiology; lymph node dissection; middle aged; mortality; pathology; penis tumor; squamous cell carcinoma; surgery; tertiary care center |
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John Wiley and Sons Inc |
9198172 |
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38641982 |
Article |
Q2 |
694 |
7174 |
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22 |
Habiburrahman M.; Sutopo S.; Sarkowi W.K. |
Habiburrahman, Muhammad (57204537114); Sutopo, Stefanus (57749107800); Sarkowi, Widya Khairunnisa (58485303400) |
57204537114; 57749107800; 58485303400 |
Plausible use of citicoline as an adjuvant in central nervous system infections: A case report and review of the literature |
2024 |
World Academy of Sciences Journal |
6 |
4 |
e39 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85195882024&doi=10.3892%2fwasj.2024.254&partnerID=40&md5=dc2840fd07b17d5dc90d220da79c121a |
Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, 10430, Indonesia; Dr. Cipto Mangunkusumo Hospital, Central Jakarta, DKI Jakarta, 10430, Indonesia; Tebet Subdistrict Public Hospital, South Jakarta, DKI Jakarta, 12810, Indonesia; Faculty of Medicine, Imperial College London, London, SW7 2AZ, United Kingdom; School of Infection and Immunity, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, United Kingdom; Faculty of Medicine, IPB University, West Java, Bogor, 16680, Indonesia; Faculty of Medicine, Universitas Indonesia, Salemba Raya Street No. 6, Senen Subdistrict, Central Jakarta, DKI Jakarta, 10430, Indonesia |
Habiburrahman M., Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, 10430, Indonesia, Dr. Cipto Mangunkusumo Hospital, Central Jakarta, DKI Jakarta, 10430, Indonesia, Tebet Subdistrict Public Hospital, South Jakarta, DKI Jakarta, 12810, Indonesia, Faculty of Medicine, Imperial College London, London, SW7 2AZ, United Kingdom, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street No. 6, Senen Subdistrict, Central Jakarta, DKI Jakarta, 10430, Indonesia; Sutopo S., Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, 10430, Indonesia, Dr. Cipto Mangunkusumo Hospital, Central Jakarta, DKI Jakarta, 10430, Indonesia, School of Infection and Immunity, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, United Kingdom, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street No. 6, Senen Subdistrict, Central Jakarta, DKI Jakarta, 10430, Indonesia; Sarkowi W.K., Faculty of Medicine, Imperial College London, London, SW7 2AZ, United Kingdom, Faculty of Medicine, IPB University, West Java, Bogor, 16680, Indonesia |
Citicoline has been widely used for the treatment of neurological conditions of the central nervous system (CNS), and exhibit potential for infection management, providing anti-inflammatory, antiviral, antioxidant and neuroprotective properties. The present study describes the case of a 50-year-old male patient co-infected with suspected tuberculosis and COVID-19 affecting the CNS who was treated with citicoline. The study aimed to raise clinical questions and initiate a comprehensive literature review. It also aimed to explore the plausible benefits of the use of citicoline in restoring consciousness and alleviating neurological symptoms in CNS infections. In the literature review, eight studies, including two quasi-experimental studies, five literature reviews, and one case report were found to be relevant to the case of the patient described herein, and they suggested that citicoline demonstrated partial protection against cerebral malaria, prevented encephalitis sequelae when immediately administered, and inhibited coronavirus replication. Additionally, six studies reported the potential of citicoline in the treatment of neurological conditions, such as ethambutol-induced optic neuropathy, stroke, head trauma and CNS infections caused by cerebral malaria and COVID-19, compared to standard therapy. Citicoline shows promise as an adjuvant therapy for neurological complications associated with CNS infections. © 2024 Spandidos Publications. All rights reserved. |
adjuvant therapy; central nervous system infections; citicoline; evidence-based case report; neurological disorders |
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Spandidos Publications |
26322900 |
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Article |
Q3 |
317 |
14612 |
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24 |
Yunus R.E.; Sriyana A.A. |
Yunus, Reyhan E. (57215658457); Sriyana, Ayu A. (57203022550) |
57215658457; 57203022550 |
Unusual presentation of bilateral tuberculous otomastoiditis with tuberculous spondylitis in a 14-year-old child: A case report |
2024 |
Radiology Case Reports |
19 |
7 |
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2679 |
2683 |
4 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85190330097&doi=10.1016%2fj.radcr.2024.03.060&partnerID=40&md5=8c5c628ad56dee44ac1a56f94ae271b3 |
Department of Radiology, Dr. Cipto Mangunkusumo General Hospital-Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Department of Otorhinolaryngology, Head and Neck Surgery, Dr. Cipto Mangunkusumo General Hospital-Faculty of Medicine University of Indonesia, Jakarta, Indonesia |
Yunus R.E., Department of Radiology, Dr. Cipto Mangunkusumo General Hospital-Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Sriyana A.A., Department of Otorhinolaryngology, Head and Neck Surgery, Dr. Cipto Mangunkusumo General Hospital-Faculty of Medicine University of Indonesia, Jakarta, Indonesia |
Tuberculous otomastoiditis, a rare manifestation of tuberculosis in the head and neck region, poses diagnostic and therapeutic challenges due to its non-specific clinical features and potential debilitating complications. While typically arising from direct spread from adjacent organs, the coexistence of tuberculous otomastoiditis and cervical spondylitis is rarely reported. We present the case of a 14-year-old male with a 3-month history of painless bilateral ear discharge resistant to antibiotic therapy. The clinical and radiological findings raised suspicions of tuberculous otomastoiditis and spondylitis, which was later confirmed by histopathological examination despite negative microbiological cultures. This case underscores the significance of considering tuberculosis in conditions involving multiple organs, especially when persistent extensive damage is observed despite optimal initial treatments. © 2024 |
Children; Mastoiditis; Otitis media; Spondylitis; Tuberculosis |
tuberculostatic agent; abscess; adolescent; Article; bacterial arthritis; bilateral tuberculous otomastoiditis; case report; caseation; cervical lymphadenopathy; cervical spine radiography; clinical article; computer assisted tomography; ear edema; eardrum perforation; fifth cervical vertebra; fistula; granulomatous inflammation; hearing impairment; histopathology; human; human tissue; Langhans giant cell; male; mastoiditis; meningitis; neck pain; nuclear magnetic resonance imaging; osteomyelitis; otitis media; paravertebral abscess; physical examination; surgical debridement; tuberculosis; tuberculous spondylitis |
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Elsevier Inc. |
19300433 |
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Article |
Q4 |
226 |
17897 |
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