Per 31 Juli 2024 (607 artikel)

Riset dan Pengabdian Masyarakat Do Research Sosial Service and Innovation

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9	Tarwadi; Pambudi S.; Sriherwanto C.; Sasangka A.N.; Bowolaksono A.; Wijayadikusumah A.R.; Zeng W.; Rachmawati H.; Kartasasmita R.E.; Kazi M.	Tarwadi (24169949500); Pambudi, Sabar (37115903900); Sriherwanto, Catur (57217729443); Sasangka, Ayu N. (59230814400); Bowolaksono, Anom (57205093224); Wijayadikusumah, Acep R. (57194976916); Zeng, Weiguang (7203023746); Rachmawati, Heni (8601757900); Kartasasmita, Rahmana E. (7801610135); Kazi, Mohsin (56921753300)	24169949500; 37115903900; 57217729443; 59230814400; 57205093224; 57194976916; 7203023746; 8601757900; 7801610135; 56921753300	Inclusion of TAT and NLS sequences in lipopeptide molecules generates homogenous nanoparticles for gene delivery applications	2024	International Journal of Pharmaceutics	662	124492				0	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85199330549&doi=10.1016%2fj.ijpharm.2024.124492&partnerID=40&md5=9c578d41204bfdb56f0acbef272c4748	Research Center for Vaccines and Drugs, National Agency for Research and Innovation (BRIN), Building 610-611 Puspiptek Area, Banten, Tangerang Selatan, 15314, Indonesia; PT Indomabs Biosantika Utama, Gedung Technology Business and Innovation Centre (TBIC), Pengasinan, Gunung Sindur, Kabupaten Bogor, Jawa Barat, 16340, Indonesia; Research Centre for Applied Microbiology, National Agency for Research and Innovation (BRIN), Building 610-611 Puspiptek Area, Banten, Tangerang Selatan, 15314, Indonesia; Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jawa Barat, Depok, 16424, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Jawa Barat, Depok, 16424, Indonesia; Research and Development Division, PT. Bio Farma, Jl. Pasteur No 28 Bandung, Jawa Barat, 40161, Indonesia; Peter Doherty Institute, The University of Melbourne, 792 Elizabeth St, Melbourne, 3000, VIC, Australia; School of Pharmacy, Bandung Institute of Technology, Jl. Ganesa 10 Bandung, Jawa Barat, 40132, Indonesia; Research Centre of Nano Sciences and Nanotechnology, Bandung Institute of Technology, Jl. Ganesa 10 Bandung 40132, Jawa Barat, Indonesia; Department of Pharmaceutics, College of Pharmacy, POBOX-2457, King Saud University, Riyadh, 11451, Saudi Arabia	Tarwadi, Research Center for Vaccines and Drugs, National Agency for Research and Innovation (BRIN), Building 610-611 Puspiptek Area, Banten, Tangerang Selatan, 15314, Indonesia, PT Indomabs Biosantika Utama, Gedung Technology Business and Innovation Centre (TBIC), Pengasinan, Gunung Sindur, Kabupaten Bogor, Jawa Barat, 16340, Indonesia; Pambudi S., Research Center for Vaccines and Drugs, National Agency for Research and Innovation (BRIN), Building 610-611 Puspiptek Area, Banten, Tangerang Selatan, 15314, Indonesia; Sriherwanto C., Research Centre for Applied Microbiology, National Agency for Research and Innovation (BRIN), Building 610-611 Puspiptek Area, Banten, Tangerang Selatan, 15314, Indonesia; Sasangka A.N., Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jawa Barat, Depok, 16424, Indonesia; Bowolaksono A., Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Jawa Barat, Depok, 16424, Indonesia; Wijayadikusumah A.R., Research and Development Division, PT. Bio Farma, Jl. Pasteur No 28 Bandung, Jawa Barat, 40161, Indonesia; Zeng W., Peter Doherty Institute, The University of Melbourne, 792 Elizabeth St, Melbourne, 3000, VIC, Australia; Rachmawati H., School of Pharmacy, Bandung Institute of Technology, Jl. Ganesa 10 Bandung, Jawa Barat, 40132, Indonesia, Research Centre of Nano Sciences and Nanotechnology, Bandung Institute of Technology, Jl. Ganesa 10 Bandung 40132, Jawa Barat, Indonesia; Kartasasmita R.E., School of Pharmacy, Bandung Institute of Technology, Jl. Ganesa 10 Bandung, Jawa Barat, 40132, Indonesia; Kazi M., Department of Pharmaceutics, College of Pharmacy, POBOX-2457, King Saud University, Riyadh, 11451, Saudi Arabia	Purposes: The objective of this study is to develop a versatile gene carrier based on lipopeptides capable of delivering genetic material into target cells with minimal cytotoxicity. Methods: Two lipopeptide molecules, palmitoyl-CKKHH and palmitoyl-CKKHH-YGRKKRRQRRR-PKKKRKV, were synthesized using solid phase peptide synthesis and evaluated as transfection agents. Physicochemical characterization of the lipopeptides included a DNA shift mobility assay, particle size measurement, and transmission electron microscopy (TEM) analysis. Cytotoxicity was assessed in CHO-K1 and HepG2 cells using the MTT assay, while transfection efficiency was determined by evaluating the expression of the green fluorescent protein-encoding gene. Results: Our findings demonstrate that the lipopeptides can bind, condense, and shield DNA from DNase degradation. The inclusion of the YGRKKRRQRRR sequence, a transcription trans activator, and the PKKKRKV sequence, a nuclear localization signal, imparts desirable properties. Lipopeptide-based TAT-NLS/DNA nanoparticles exhibited stability for up to 20 days when stored at 6–8 °C, displaying uniformity with a compact size of approximately 120 nm. Furthermore, the lipopeptides exhibited lower cytotoxicity compared to the poly-L-lysine. Transfection experiments revealed that protein expression mediated by the lipopeptide occurred at a charge ratio ranging from 4.0 to 8.0. Conclusion: These results indicate that the lipopeptide, composed of a palmitoyl alkyl chain and TAT and NLS sequences, can efficiently condense and protect DNA, form stable and uniform nanoparticles, and exhibit promising characteristics as a potential gene carrier with minimal cytotoxicity. © 2024 Elsevier B.V.	Cytotoxicity; Homogenous nanoparticle; Lipopeptide; NLS; TAT; Transfection		King Saud University, KSU; Agency for Research and Innovation; University of Melbourne, UNIMELB, (12/II.7/HK/2023); BRIN, (RSP2024R301)	We extend our gratitude to Professor David Jackson for his invaluable contribution to lipopeptide synthesis conducted at the Peter Doherty Institute Laboratory, The University of Melbourne, Australia. We also express our appreciation to the support of Research and Innovation Program for Advancement of Indonesia (RIIM) Project Number of 12/II.7/HK/2023 at the Agency for Research and Innovation (BRI	Elsevier B.V.	3785173		Article	Q1	906	4937	View
19	Siregar G.O.; Harianja M.; Adella J.; Krismawati H.; Sundari E.S.; Ataupah M.R.; Laiskodat R.D.; Bøgh C.; Soebono H.; Grijsen M.L.	Siregar, Gladys O. (58876649500); Harianja, Maria (58876435800); Adella, Jacklyn (58994793100); Krismawati, Hana (56572770100); Sundari, Evivana S. (58876435900); Ataupah, Messe R. (58993911900); Laiskodat, Ruth D. (58994354700); Bøgh, Claus (6602120205); Soebono, Hardyanto (6508242918); Grijsen, Marlous L. (25225113700)	58876649500; 58876435800; 58994793100; 56572770100; 58876435900; 58993911900; 58994354700; 6602120205; 6508242918; 25225113700	Leprosy identified in Sumba Island, eastern Indonesia: elimination targets under threat	2024	The Lancet Regional Health - Southeast Asia	26	100409				0	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85190856063&doi=10.1016%2fj.lansea.2024.100409&partnerID=40&md5=4f24b635df4260f90f0d5f674d9efa33	Sumba Foundation, Sumba, Indonesia; Center of Health System and Strategy, Ministry of Health, Jakarta, Indonesia; Department of Dermatology and Venereology, Siloam Hospital, Kupang, Indonesia; Province Health Office, East Nusa Tenggara, Kupang, Indonesia; Department of Dermatology and Venereology, Gadjah Mada University, Yogyakarta, Indonesia; Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, United Kingdom	Siregar G.O., Sumba Foundation, Sumba, Indonesia; Harianja M., Sumba Foundation, Sumba, Indonesia; Adella J., Sumba Foundation, Sumba, Indonesia; Krismawati H., Center of Health System and Strategy, Ministry of Health, Jakarta, Indonesia; Sundari E.S., Department of Dermatology and Venereology, Siloam Hospital, Kupang, Indonesia; Ataupah M.R., Province Health Office, East Nusa Tenggara, Kupang, Indonesia; Laiskodat R.D., Province Health Office, East Nusa Tenggara, Kupang, Indonesia; Bøgh C., Sumba Foundation, Sumba, Indonesia; Soebono H., Department of Dermatology and Venereology, Gadjah Mada University, Yogyakarta, Indonesia; Grijsen M.L., Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, United Kingdom	[No abstract available]		awareness; disease burden; disease transmission; health care personnel; human; leprosy; multibacillary leprosy; nerve injury; Note; paucibacillary leprosy; polypharmacy; primary health care; skin care; teledermatology; telemedicine	Wellcome Trust, WT; Sumba Foundation	Funding text 1: The project was financially supported by the Wellcome Trust Africa Asia Programme Vietnam. The authors declare that they have no conflicts of interest. ; Funding text 2: We extend our sincere gratitude to all Sumba Foundation healthcare workers. We wish to acknowledge Ben Naafs for sharing his expertise on leprosy with the clinical team.	Elsevier Ltd	27723682		Note	#N/A	#N/A	#N/A	View
26	Oesman I.; Putra N.H.D.; Andar A.A.; Mardhitiyani W.A.	Oesman, Ihsan (57203961169); Putra, Nurmansyah Hata Dwi (57223369199); Andar, Anindyo Abshar (58962361600); Mardhitiyani, Winona Andrari (59221408900)	57203961169; 57223369199; 58962361600; 59221408900	Flexor hallucis longus impingement syndrome: A case report	2024	International Journal of Surgery Case Reports	121	109934				0	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85198732593&doi=10.1016%2fj.ijscr.2024.109934&partnerID=40&md5=ab9f82c160bc5c9fbe842e4e047bc70f	Foot and Ankle Division, Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Orthopaedics and Traumatology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Oesman I., Foot and Ankle Division, Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Putra N.H.D., Department of Orthopaedics and Traumatology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Andar A.A., Department of Orthopaedics and Traumatology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mardhitiyani W.A., Department of Orthopaedics and Traumatology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Introduction and importance: Long-term friction of the FHL tendon's sheath (caused by sporting activities) can result in tendinitis, which causes pain in the foot and ankle and consequently interferes with everyday life and foot function. The FHL tendon is crucial for maintaining foot stability and can be damaged by overuse. FHL tendinitis can be also caused by inflammatory tendon sheath filled. Arthroscopy can play a role in the diagnosis and treatment of this condition. Case presentation: A 28-year-old female with left ankle pain was brought to our clinic after slipping on a train platform nine months ago. X-rays and MR imaging revealed a complete tear of the ATFL, minimal joint effusion, and a bony protrusion causing impingement. Arthroscopic surgery was performed, and the patient's pain sensation improved to 0–1 in the visual analogue scale (VAS) within three weeks. The Foot and Ankle Ability Measure (FAAM) score increased from 8 % to 100 %, and the patient was able to walk and perform daily activities normally. Clinical discussion: The FHL tendon sheath begins at the posterior tubercles of the talus and forms a fibroosseous tunnel along the medial calcaneus, potentially leading to impingement during ankle or hallux dorsiflexion. FHL tendon impingement and tendinitis share clinical manifestations, and if conservative treatments (NSAIDs, physical therapy) fail after 6 months, arthroscopic surgery is recommended for its minimally invasive benefits. Both arthroscopic and open surgical techniques yield positive outcomes for FHL pathologies; however, they carry risks such as neurovascular complications, highlighting the necessity for surgical precision and expertise. Conclusion: We concluded that in this case, FHL impingement was caused by the bony protrusion from Stieda process fragment. It was demonstrated that the arthroscopic surgery with loose body removal was successful and practical. © 2024 The Authors	Arthroscopic surgery; Flexor hallucis longus; Impingement syndrome; Loose boby; Tendinitis	achilles tendon; adult; adverse event; ankle; ankle dorsiflexion angle; ankle pain; ankle plantarflexion angle; arthroscopic surgery; Article; avulsion fracture; bacterial arthritis; capillary refill time; case report; clinical article; daily life activity; fat pad; female; flexor hallucis longus impingement syndrome; flexor hallucis longus muscle; Foot and Ankle Ability Measure; hospital; human; joint effusion; leg edema; limb disease; medical history; nociception; nuclear magnetic resonance imaging; physical examination; physiotherapy; postoperative period; soft tissue; surgical infection; talocrural joint; talofibular joint; talonavicular joint; talus; tendinitis; tendon sheath; tibiofibular joint; visual analog scale; walking; X ray			Elsevier Ltd	22102612		Article	Q3	193	19555	View
31	Moegni F.; Kouwagam A.D.; Hakim S.; Priyatini T.; Meutia A.P.; Santoso B.I.	Moegni, Fernandi (55450456100); Kouwagam, Anggrainy Dwifitriana (57225978823); Hakim, Surahman (57192276095); Priyatini, Tyas (57192265423); Meutia, Alfa Putri (57203368133); Santoso, Budi Iman (57201498069)	55450456100; 57225978823; 57192276095; 57192265423; 57203368133; 57201498069	Rectovaginal fistula as a complication of rectal injury during vaginal reconstructive surgery: A case report	2024	International Journal of Surgery Case Reports	120	109856				0	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85196201861&doi=10.1016%2fj.ijscr.2024.109856&partnerID=40&md5=474e5b9f2894a7d3b432448304bb7256	Division of Urogynecology and Reconstruction, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo National General Hospital, Indonesia	Moegni F., Division of Urogynecology and Reconstruction, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo National General Hospital, Indonesia; Kouwagam A.D., Division of Urogynecology and Reconstruction, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo National General Hospital, Indonesia; Hakim S., Division of Urogynecology and Reconstruction, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo National General Hospital, Indonesia; Priyatini T., Division of Urogynecology and Reconstruction, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo National General Hospital, Indonesia; Meutia A.P., Division of Urogynecology and Reconstruction, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo National General Hospital, Indonesia; Santoso B.I., Division of Urogynecology and Reconstruction, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo National General Hospital, Indonesia	Introduction and importance: Rectovaginal fistula is a complication that may occur due to rectal injury during vaginal reconstructive surgery. To prevent these complications, the recognition of the injury is an important factor so that primary repair can be done. The primary repair can reduce the risk of complications such as fistula formation, and also reduce the physical and psychological impact on the patient. Case presentation: A 33-year-old woman, came with a chief complaint of fecal leakage from the vagina and abdominal pain three months before admission with a history of vaginal reconstructive surgery due to vaginal agenesis. Eleven years after the reconstruction, the patient was diagnosed with recurrent obstruction caused by vaginal synechia. During the surgery of synechia release, rectum injury occurred. Even though primary closure repair was done at that time, several months later there was a complication of rectovaginal fistule formation in the form of fecal leakage from the vagina. The corrective surgery is performed in collaboration with a surgical gastroenterologist. Clinical discussion: Iatrogenic rectal injury may occur during gynecological surgery. A fistula that occurs after the reconstruction of vaginal agenesis is a high-type rectovaginal fistula, making the repairs more complex. Collaboration surgery between surgical gastroenterologist and gynecologist may be an option in such cases. Conclusion: Rectovaginal fistula is a rare but serious complication of vaginal reconstructive surgery. Early recognition, immediate management, and postoperative follow-up are essential in cases of rectal injury during vaginal reconstructive surgery. © 2024	Rectovaginal fistula; Vaginal agenesis; Vaginal reconstructive surgery	abdominal hysterectomy; abdominal pain; adhesiolysis; adult; amnion; Article; case report; cervicovaginal synechia; clinical article; clinical outcome; echography; feces incontinence; female; gastroenterologist; hematometra; hematosalpinx; hospital admission; human; iatrogenic disease; implantation; laparotomy; menstruation disorder; middle aged; ovarian cystectomy; rectovaginal fistula; rectum perforation; recurrent disease; salpingectomy; surgical approach; surgical injury; tissue adhesion; urogynecologist; uterine tube disease; vagina aplasia; vagina reconstruction; Wexner score			Elsevier Ltd	22102612		Article	Q3	193	19555	View
34	Dirjayanto V.J.; Martin-Ruiz C.; Pompei G.; Rubino F.; Kunadian V.	Dirjayanto, Valerie Josephine (57404619000); Martin-Ruiz, Carmen (6701718262); Pompei, Graziella (57242359600); Rubino, Francesca (57208753088); Kunadian, Vijay (55390915800)	57404619000; 6701718262; 57242359600; 57208753088; 55390915800	The association of inflammatory biomarkers and long-term clinical outcomes in older adults with non-ST elevation acute coronary syndrome	2024	International Journal of Cardiology	409	132177				1	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85193480301&doi=10.1016%2fj.ijcard.2024.132177&partnerID=40&md5=8b9f741259fcdc823e950f8afd151a9c	Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, United Kingdom; Faculty of Medicine, Universitas Indonesia, Indonesia; BioScreening Core Facility, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom; Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, FE, Cona, Italy; Division of Cardiology, Department of Medicine, University of Verona, Verona, Italy; Cardiothoracic Centre, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom	Dirjayanto V.J., Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, United Kingdom, Faculty of Medicine, Universitas Indonesia, Indonesia; Martin-Ruiz C., BioScreening Core Facility, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom; Pompei G., Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, United Kingdom, Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, FE, Cona, Italy; Rubino F., Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, United Kingdom, Division of Cardiology, Department of Medicine, University of Verona, Verona, Italy; Kunadian V., Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, United Kingdom, Cardiothoracic Centre, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom	Background: The prognostic significance of inflammatory markers on the long-term risk of major adverse cardiovascular and cerebrovascular events (MACCE) in older NSTEACS patients remains unclear. Methods: NSTEACS patients aged 75 and older were recruited to the multicentre cohort study Improve Cardiovascular Outcomes in High-Risk PatieNts with Acute Coronary Syndrome (ICON1). Inflammatory markers including interleukin-6 (IL-6), myeloperoxidase (MPO), high-sensitivity C-reactive protein (hsCRP), fibrinogen and tumor necrosis factor-alpha (TNF-α) were collected at baseline. Primary outcome was MACCE consisting of all-cause mortality, reinfarction, stroke/transient ischaemic attack, urgent revascularization, and significant bleeding at 5-year follow-up. Results: There were 230 patients with baseline IL-6 (median age 80.9 [interquartile range (IQR):78.2–83.9] years). High IL-6 was not associated with MACCE, but it was independently associated with all-cause mortality (adjusted hazard ratio [aHR]: 2.26 [95% Confidence Interval (CI):1.34–3.82]; P = 0.002). For patients with hsCRP (n = 260, median age 80.9 [IQR:77.9–84.1] years), higher levels were significantly associated with increased risk of MACCE (aHR:1.77 [95% CI:1.26–2.49], P = 0.001). In the cohort with MPO (230 patients, median age 80.9 [IQR:78.2–83.9] years), lower MPO was independently associated with the risk of MACCE (aHR: 0.67 [95%CI:0.46–0.96]; P = 0.029). There was no prognostic significance with fibrinogen and TNF-α. Conclusion: Among older NSTEACS patients, elevated IL-6 and hsCRP were associated with increased risk of all-cause mortality and MACCE, respectively. Low MPO levels were associated with higher MACCE. Further studies are required to determine how these biomarkers should influence treatment strategy in this understudied subset. Clinical Trial Registration: NCT01933581 © 2024 Elsevier B.V.	Inflammatory biomarkers; Major adverse cardiovascular events; Non-ST elevation acute coronary syndrome; Older adults	Acute Coronary Syndrome; Aged; Aged, 80 and over; Biomarkers; C-Reactive Protein; Cohort Studies; Female; Follow-Up Studies; Humans; Inflammation; Interleukin-6; Male; Peroxidase; Prognosis; Time Factors; Treatment Outcome; biological marker; C reactive protein; fibrinogen; interleukin 6; myeloperoxidase; troponin; tumor necrosis factor; C reactive protein; interleukin 6; peroxidase; acute coronary syndrome; adult; all cause mortality; angiography; Article; atrial fibrillation; blood pressure; cardiogenic shock; cardiomyopathy; cardiovascular disease; cerebrovascular accident; chi square test; clinical outcome; confidence interval; coronary artery bypass graft; demographics; electrocardiography; enzyme linked immunosorbent assay; follow up; hazard ratio; heart arrhythmia; heart reinfarctio	NIHR Newcastle Biomedical Research Centre; National Institute for Health and Care Research, NIHR; Newcastle cardiovascular research team; Newcastle University; Newcastle upon Tyne Hospitals NHS Foundation Trust; British Heart Foundation, BHF, (CS/15/7/31679); British Heart Foundation, BHF	We are grateful to the Newcastle cardiovascular research team for their support with the long-term follow-up. This research is supported by the National Institute for Health Research (NIHR) Newcastle Biomedical Research Centre based at Newcastle-upon-Tyne Hospitals NHS Foundation Trust and Newcastle University. VK has received research funding from the British Heart Foundation (CS/15/7/31679).	Elsevier Ireland Ltd	1675273	38761976	Article	Q1	1122	3475	View
37	Subahar R.; Hadyansyah R.; Aldilla R.; Yulhasri Y.; Winita R.; Dwira S.; El Bayani G.F.	Subahar, Rizal (6508197883); Hadyansyah, Rizqy (59229205600); Aldilla, Rachmanin (59229088300); Yulhasri, Yulhasri (57225180520); Winita, Rawina (57220782528); Dwira, Surya (57204110404); El Bayani, Gulshan Fahmi (57195935050)	6508197883; 59229205600; 59229088300; 57225180520; 57220782528; 57204110404; 57195935050	Toxicity of 6-gingerol and Cymbopogon citratus against Pediculus humanus capitis De Geer (Phthiraptera: Pediculidae): Mortality, detoxifying enzymes, and morphological ultrastructure alterations in lice	2024	Research in Veterinary Science	177	105364				0	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85199254708&doi=10.1016%2fj.rvsc.2024.105364&partnerID=40&md5=5a3d6ac21849f052aa2759615983adda	Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Medical Doctor Program, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Department of Medical Physiology and Biophysics, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia	Subahar R., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Hadyansyah R., Medical Doctor Program, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Aldilla R., Medical Doctor Program, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Yulhasri Y., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Winita R., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Dwira S., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; El Bayani G.F., Department of Medical Physiology and Biophysics, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia	Pediculus humanus capitis (head louse), which causes pediculosis capitis, remains a global health concern. Plant products are efficient alternative pediculicides for treating the human ectoparasite P. h. capitis which is resistant to permethrin. The study evaluates the toxicity and mechanisms of 6-gingerol and Cymbopogon citratus leaf extract on P. h. capitis. Pediculus humanus capitis adult stages were exposed to three different dosages of 6-gingerol and C. citratus crude leaf extract on filter sheets for 5, 10, and 30 min, respectively. The biochemical approach was used to assess the activity of detoxifying enzymes including acetylcholinesterase (AChE), glutathione S-transferase (GST), and oxidase. Scanning electron microscope (SEM) was used to investigate the ultrastructure of the morphological body of lice. After 30 min, 6-gingerol and C. citratus leaf extract killed P. h. capitis completely. Bioassay periods significantly affected lice mortality (P < 0.05). The LC50 values for 6-gingerol and C. citratus extract were 1.79 μg/cm2 and 25.0 μg/cm2, respectively. 6-Gingerol and C. citratus leaf extract significantly lower AChE and GST activity (P < 0.05). Cymbopogon citratus also caused morphological ultrastructure changes in P. h. capitis, including an irregularly formed head, thorax, abdominal respiratory spiracles, and belly. 6-Gingerol and C. citratus leaf extracts could be used as an alternate pediculicide to decrease P. h. capitis populations. © 2024	6-gingerol; Cymbopogon citratus; Detoxification enzyme; Morphological ultrastructure of lice; Pediculus humanus capitis		Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia; Universitas Indonesia, UI, (HIBAH PUTI Q2 2020)	Funding text 1: This research was funded by the Directorate of Research and Community Service at the Universitas Indonesia (grant no. HIBAH PUTI Q2 2020).This research was funded by theThe Directorate of Research and Development at the Universitas Indonesia (grant number HIBAH PUTI Q2 2020). The authors would like to thank the Head of the Department of Parasitology and the Head of the Department o	Elsevier B.V.	345288		Article	Q1	577	8960	View
46	Gach M.W.; Lazarus G.; Simadibrata D.M.; Sinto R.; Saharman Y.R.; Limato R.; Nelwan E.J.; van Doorn H.R.; Karuniawati A.; Hamers R.L.	Gach, Michael W. (57675752100); Lazarus, Gilbert (57214599425); Simadibrata, Daniel Martin (57202134322); Sinto, Robert (36099377100); Saharman, Yulia Rosa (55980934300); Limato, Ralalicia (57196224631); Nelwan, Erni J. (14527452900); van Doorn, H. Rogier (56941604800); Karuniawati, Anis (54886816200); Hamers, Raph L. (23034345900)	57675752100; 57214599425; 57202134322; 36099377100; 55980934300; 57196224631; 14527452900; 56941604800; 54886816200; 23034345900	Antimicrobial resistance among common bacterial pathogens in Indonesia: a systematic review	2024	The Lancet Regional Health - Southeast Asia	26	100414				0	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85192810137&doi=10.1016%2fj.lansea.2024.100414&partnerID=40&md5=8b7941694224b5ac273f8fd664e75b48	Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Department of Internal Medicine, Division of Tropical Medicine and Infectious Diseases, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Clinical Microbiology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Oxford University Clinical Research Unit, Hanoi, Viet Nam	Gach M.W., Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Lazarus G., Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Simadibrata D.M., Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States; Sinto R., Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Department of Internal Medicine, Division of Tropical Medicine and Infectious Diseases, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Saharman Y.R., Department of Clinical Microbiology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Limato R., Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Nelwan E.J., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Internal Medicine, Division of Tropical Medicine and Infectious Diseases, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; van Doorn H.R., Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Oxford University Clinical Research Unit, Hanoi, Viet Nam; Karuniawati A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Clinical Microbiology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Hamers R.L., Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom	Background: The WHO Global Antimicrobial Resistance Surveillance System (GLASS) aims to describe antimicrobial resistance (AMR) patterns and trends in common bacterial pathogens, but data remain limited in many low and middle-income countries including Indonesia. Methods: We systematically searched Embase, PubMed and Global Health Database and three Indonesian databases for original peer-reviewed articles in English and Indonesian, published between January 1, 2000 and May 25, 2023, that reported antimicrobial susceptibility for the 12 GLASS target pathogens from human samples. Pooled AMR prevalence estimates were calculated for relevant pathogen-antimicrobial combinations accounting for the sampling weights of the studies (PROSPERO: CRD42019155379). Findings: Of 2182 search hits, we included 102 papers, comprising 19,517 bacterial isolates from hospitals (13,647) and communities (5870). In hospital settings, 21.6% of Klebsiella pneumoniae isolates, 18.3% of Escherichia coli isolates, 35.8% of Pseudomonas aeruginosa isolates and 70.7% of Acinetobacter baumannii isolates were carbapenem-resistant; 29.9% of Streptococcus pneumoniae isolates were penicillin-resistant; and 22.2% of Staphylococcus aureus isolates were methicillin-resistant. Hospital prevalence of carbapenem-resistant K. pneumoniae and E. coli, and penicillin-resistant S. pneumoniae increased over time. In communities, 28.3% of K. pneumoniae isolates and 15.7% of E. coli isolates were carbapenem-resistant, 23.9% of S. pneumoniae isolates were penicillin-resistant, and 11.1% of S. aureus isolates were methicillin-resistant. Data were limited for the other pathogens. Interpretation: AMR prevalence estimates were high for critical gram-negative bacteria. However, data were insufficient to draw robust conclusions about the full contemporary AMR situation in Indonesia. Implementation of national AMR surveillance is a priority to address these gaps and inform context-specific interventions. Funding: Wellcome Africa Asia Programme Vietnam. © 2024 The Author(s)	Antimicrobial resistance; Antimicrobial susceptibility; Bacteria; GLASS; Indonesia; Systematic review	amikacin; cefepime; cefoxitin; ceftazidime; cephalosporin; colistin; cotrimoxazole; doripenem; extended spectrum beta lactamase; fosfomycin; gentamicin; imipenem; meropenem; nitrofurantoin; oxacillin; piperacillin plus tazobactam; quinoline derived antiinfective agent; tigecycline; tobramycin; Acinetobacter baumannii; antibacterial activity; antibiotic resistance; antibiotic sensitivity; Article; bacterial load; bacterium isolation; carbapenem resistance; community acquired infection; disk diffusion; epsilometer test; Escherichia coli; geographic distribution; Haemophilus influenzae; hospital infection; human; Indonesia; infection risk; Klebsiella pneumoniae; matrix assisted laser desorption ionization time of flight mass spectrometry; meta analysis; methicillin resistance; methicillin res	Kementerian Pendidikan, Kebudayaan, Riset, dan Teknologi, MECRT; Oxford University Clinical Academic Graduate School, OUCAGS; OUCRU; JPT Family Trust; Ministry of Education, Culture, Research, and Technology Republic of Indonesia; Wellcome Africa Asia Programme Vietnam, (106680/Z/14/Z); Lembaga Pengelola Dana Pendidikan, LPDP, (202101182688); Lembaga Pengelola Dana Pendidikan, LPDP	Funding text 1: Wellcome Africa Asia Programme Vietnam.None. Funding statement: This work was funded by the Wellcome Africa Asia Programme Vietnam (106680/Z/14/Z), which also supports RLH and HRVD. MG was supported by the JPT Family Trust award and Oxford University Clinical Academic Graduate School. RL was supported by an OUCRU Prize Studentship and a Nuffield Dept of Medicine Tropical Network Fu	Elsevier Ltd	27723682		Article	#N/A	#N/A	#N/A	View
59	Yusuf P.A.; Hubka P.; Konerding W.; Land R.; Tillein J.; Kral A.	Yusuf, Prasandhya A. (57192156597); Hubka, Peter (6506008977); Konerding, Wiebke (37114569200); Land, Rüdiger (55496762300); Tillein, Jochen (6602884109); Kral, Andrej (55668482500)	57192156597; 6506008977; 37114569200; 55496762300; 6602884109; 55668482500	Congenital deafness reduces alpha-gamma cross-frequency coupling in the auditory cortex	2024	Hearing Research	449	109032				0	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85194041822&doi=10.1016%2fj.heares.2024.109032&partnerID=40&md5=6690a67c120d37697984b278b6b910f6	Hannover Medical School, Institute of AudioNeuroTechnology and Department of Experimental Otology of the ENT Clinics, Hannover, Germany; Faculty of Medicine University of Indonesia, Department of Medical Physiology and Biophysics / Medical Technology IMERI, Jakarta, Indonesia; J.W. Goethe University, Department of Otorhinolaryngology, Frankfurt am Main, Germany; Australian Hearing Hub, School of Medicine and Health Sciences, Macquarie University, Sydney, Australia	Yusuf P.A., Hannover Medical School, Institute of AudioNeuroTechnology and Department of Experimental Otology of the ENT Clinics, Hannover, Germany, Faculty of Medicine University of Indonesia, Department of Medical Physiology and Biophysics / Medical Technology IMERI, Jakarta, Indonesia; Hubka P., Hannover Medical School, Institute of AudioNeuroTechnology and Department of Experimental Otology of the ENT Clinics, Hannover, Germany; Konerding W., Hannover Medical School, Institute of AudioNeuroTechnology and Department of Experimental Otology of the ENT Clinics, Hannover, Germany; Land R., Hannover Medical School, Institute of AudioNeuroTechnology and Department of Experimental Otology of the ENT Clinics, Hannover, Germany; Tillein J., J.W. Goethe University, Department of Otorhinolaryngology, Frankfurt am Main, Germany; Kral A., Hannover Medical School, Institute of AudioNeuroTechnology and Department of Experimental Otology of the ENT Clinics, Hannover, Germany, Australian Hearing Hub, School of Medicine and Health Sciences, Macquarie University, Sydney, Australia	Neurons within a neuronal network can be grouped by bottom-up and top-down influences using synchrony in neuronal oscillations. This creates the representation of perceptual objects from sensory features. Oscillatory activity can be differentiated into stimulus-phase-locked (evoked) and non-phase-locked (induced). The former is mainly determined by sensory input, the latter by higher-level (cortical) processing. Effects of auditory deprivation on cortical oscillations have been studied in congenitally deaf cats (CDCs) using cochlear implant (CI) stimulation. CI-induced alpha, beta, and gamma activity were compromised in the auditory cortex of CDCs. Furthermore, top-down information flow between secondary and primary auditory areas in hearing cats, conveyed by induced alpha oscillations, was lost in CDCs. Here we used the matching pursuit algorithm to assess components of such oscillatory activity in local field potentials recorded in primary field A1. Additionally to the loss of induced alpha oscillations, we also found a loss of evoked theta activity in CDCs. The loss of theta and alpha activity in CDCs can be directly related to reduced high-frequency (gamma-band) activity due to cross-frequency coupling. Here we quantified such cross-frequency coupling in adult 1) hearing-experienced, acoustically stimulated cats (aHCs), 2) hearing-experienced cats following acute pharmacological deafening and subsequent CIs, thus in electrically stimulated cats (eHCs), and 3) electrically stimulated CDCs. We found significant cross-frequency coupling in all animal groups in > 70% of auditory-responsive sites. The predominant coupling in aHCs and eHCs was between theta/alpha phase and gamma power. In CDCs such coupling was lost and replaced by alpha oscillations coupling to delta/theta phase. Thus, alpha/theta oscillations synchronize high-frequency gamma activity only in hearing-experienced cats. The absence of induced alpha and theta oscillations contributes to the loss of induced gamma power in CDCs, thereby signifying impaired local network activity. © 2024 The Authors	Alpha band; Cochlear implant; Connectivity; Development; Hearing loss; Theta band	Acoustic Stimulation; Algorithms; Alpha Rhythm; Animals; Auditory Cortex; Auditory Pathways; Cats; Cochlear Implants; Deafness; Disease Models, Animal; Evoked Potentials, Auditory; Gamma Rhythm; Theta Rhythm; adult; alpha rhythm; animal experiment; Article; auditory cortex; auditory stimulation; beta rhythm; congenital deafness; controlled study; gamma rhythm; local field potential; low frequency oscillation; nerve cell network; nonhuman; primary auditory cortex; reproducibility; theta rhythm; vibration; algorithm; alpha rhythm; animal; auditory evoked potential; auditory nervous system; auditory stimulation; cat; cochlea prosthesis; congenital disorder; disease model; hearing impairment; pathophysiology	Universitas Indonesia, UI; Deutsche Forschungsgemeinschaft, DFG, (DFG Kr 3370); Deutsche Forschungsgemeinschaft, DFG; Deutscher Akademischer Austauschdienst, DAAD, (PUTI Q2 2020, NKB-1515/UN2.RST/HKP.05.00/2020); Deutscher Akademischer Austauschdienst, DAAD	Deutsche Forschungsgemeinschaft ( DFG Kr 3370 and Exc 2177 ); MedEl Comp, Innsbruck, Austria (to J.T.); DAAD \u2013 Indonesian German Scholarship Programme (IGSP) ; PUTI Q2 2020 (NKB-1515/UN2.RST/HKP.05.00/2020) Universitas Indonesia Publication Grant (to PAY).	Elsevier B.V.	3785955	38797035	Article	Q1	959	4505	View
66	Wang Q.; Ma T.; Ding F.; Lim A.; Takaya S.; Saraswati K.; Sartorius B.; Day N.P.J.; Maude R.J.	Wang, Qian (59093381000); Ma, Tian (57218990871); Ding, Fangyu (57194508485); Lim, Ahyoung (57222061897); Takaya, Saho (57192425070); Saraswati, Kartika (57201491297); Sartorius, Benn (12788526800); Day, Nicholas P.J. (36071528500); Maude, Richard J. (25625222500)	59093381000; 57218990871; 57194508485; 57222061897; 57192425070; 57201491297; 12788526800; 36071528500; 25625222500	Global and regional seroprevalence, incidence, mortality of, and risk factors for scrub typhus: A systematic review and meta-analysis	2024	International Journal of Infectious Diseases	146	107151				0	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85199198062&doi=10.1016%2fj.ijid.2024.107151&partnerID=40&md5=7a4bece96ed13f2a72f52fa8d09c52c1	Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, China; London School of Hygiene & Tropical Medicine, London, United Kingdom; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore; Oxford University Clinical Research Unit Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Centre for Clinical Research (UQCCR), Faculty of Medicine, University of Queensland, Brisbane, Australia; Department of Health Metric Sciences, School of Medicine, University of Washington, Seattle, United States; The Open University, Milton Keynes, United Kingdom	Wang Q., Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Ma T., Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, China, College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, China; Ding F., Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, China, College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, China; Lim A., London School of Hygiene & Tropical Medicine, London, United Kingdom; Takaya S., London School of Hygiene & Tropical Medicine, London, United Kingdom; Saraswati K., Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore, Oxford University Clinical Research Unit Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sartorius B., Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Centre for Clinical Research (UQCCR), Faculty of Medicine, University of Queensland, Brisbane, Australia, Department of Health Metric Sciences, School of Medicine, University of Washington, Seattle, United States; Day N.P.J., Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Maude R.J., Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, The Open University, Milton Keynes, United Kingdom	Objectives: Scrub typhus is underdiagnosed and underreported but emerging as a global public health problem. We aimed to provide the first comprehensive review on the seroprevalence, incidence, mortality of and risk factors for scrub typhus. Methods: We searched PubMed, Scopus, Web of Science, China National Knowledge Infrastructure and other databases. Trended incidence and median mortality were calculated and pooled seroprevalence and risk factors for scrub typhus were evaluated using the random-effects meta-analysis. Results: We included 663 articles from 29 countries/regions. The pooled seroprevalence was 10.73% (95%CI 9.47-12.13%) among healthy individuals and 22.58% (95%CI: 20.55%-24.76%) among febrile patients. Mainland China reported the highest number of cases and South Korea and Thailand had the highest incidence rates. Median mortalities were 5.00% (range: 0.00-56.00%) among hospital inpatients, 6.70% (range: 0.00-33.33%) among patients without specified admission status and 2.17% (range: 0.00-22.22%) among outpatients. The significant risk factors included agricultural work, specific vegetation exposure, other outdoor activities, risky personal health habits, and proximity to rodents, livestock, or poultry. Conclusions: Our comprehensive review elucidates the significant yet variable burden of scrub typhus across different regions, underscoring its emergence as a critical public health concern globally. © 2024 The Authors	Incidence; Mortality; Risk factor; Scrub typhus; Seroprevalence; Systematic review		Wellcome Trust, WT, (220211); National Natural Science Foundation of China, NSFC, (42201497); Youth Innovation Promotion Association, YIPA, (2023000117); NRF, (RIE2025)	Funding text 1: This research was funded in part by the Wellcome Trust [ 220211 ], National Natural Science Foundation of China [ 42201497 ], Youth Innovation Promotion Association [ 2023000117 ], and NRF International Partnership Funding Initiative [ RIE2025 ]. The funder had no role in study design, data collection, data analysis, data interpretation, or writing of this study. ; Funding text 2:	Elsevier B.V.	12019712	38964725	Article	Q1	2006	1313	View
67	Putri Meutia A.; Yonathan K.; Iman Santoso B.; Djusad S.; Priyatini T.; Hakim S.; Moegni F.; Nurul Hidayah G.	Putri Meutia, Alfa (59214830100); Yonathan, Kevin (57195941933); Iman Santoso, Budi (59214972800); Djusad, Suskhan (57192276788); Priyatini, Tyas (57192265423); Hakim, Surahman (57192276095); Moegni, Fernandi (55450456100); Nurul Hidayah, Gita (59214534300)	59214830100; 57195941933; 59214972800; 57192276788; 57192265423; 57192276095; 55450456100; 59214534300	Translation, Cross-Cultural Adaptation, and Validation of Indonesian Version of Australian Pelvic Floor Questionnaire: An Interviewer-Administered Female Pelvic Floor Questionnaire	2024	European Journal of Obstetrics and Gynecology and Reproductive Biology	300		155	158	3	0	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85198278883&doi=10.1016%2fj.ejogrb.2024.07.005&partnerID=40&md5=fc2a779c700596e0a215fdd74498f7bd	Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Indonesia; Jakarta Urogynecology Center, YPK Mandiri Hospital, Indonesia; Faculty of Medicine, Universitas Indonesia, Indonesia	Putri Meutia A., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Indonesia, Jakarta Urogynecology Center, YPK Mandiri Hospital, Indonesia; Yonathan K., Faculty of Medicine, Universitas Indonesia, Indonesia; Iman Santoso B., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Indonesia, Jakarta Urogynecology Center, YPK Mandiri Hospital, Indonesia; Djusad S., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Indonesia; Priyatini T., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Indonesia; Hakim S., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Indonesia; Moegni F., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Indonesia, Jakarta Urogynecology Center, YPK Mandiri Hospital, Indonesia; Nurul Hidayah G., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Indonesia, Jakarta Urogynecology Center, YPK Mandiri Hospital, Indonesia	Aim: To adapt and determine the validity and reliability of the Indonesian version of the Australian Pelvic Floor Questionnaire (APFQ). Methods: The original APFQ was translated and validated to obtain an Indonesian, physician-administered version on 41 urogynecology patients and 41 age-matched women without pelvic floor dysfunction. Results: Missing answers never exceeded 2%. The questionnaire can significantly discriminate between pelvic floor dysfunction patients and those without dysfunctions. The results of each domain of the questionnaire correlated with clinical examinations and another questionnaire. Cronbach's alpha scores of all domains were 0.859 for bladder function, 0.829 for bowel function, 0.892 for prolapse symptoms, and 0.766 for sexual function. Conclusion: The Indonesian version of the Australian Pelvic Floor Questionnaire (APFQ) is a valid and reliable questionnaire for assessing pelvic floor symptoms among women in Indonesia. © 2024	Pelvic floor; Prolapse; Questionnaires; Validation study	adaptation; adult; age; Article; Australian pelvic floor questionnaire; bladder function; body mass; bothersomeness; clinical article; clinical examination; community dwelling person; controlled study; convergent validity; cross-sectional study; cultural factor; cystocele; demographics; discriminant validity; educational status; face validity; female; Female Sexual Function Index; genital system disease assessment; human; Indonesia; Indonesian (language); internal consistency; intestine function; menopause; parity; pelvic floor disorder; prolapse; questionnaire; rectocele; reliability; sexual abstinence; sexual function; test retest reliability; translating (language); validity	Jakarta Urogynecology Center	The authors would like to thank all the participating patients and medical staff in Cipto Mangunkusumo National Hospital and Jakarta Urogynecology Center, Indonesia. Data and Material Availability. Data related to the results of this study are available from the corresponding author upon reasonable requests.	Elsevier Ireland Ltd	3012115		Article	#N/A	#N/A	#N/A	View

Publikasi Scopus 2024 per tanggal 31 Juli 2024 (607 artikel)