Per 31 Juli 2024 (607 artikel)

Riset dan Pengabdian Masyarakat Do Research Sosial Service and Innovation

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304	Ambarsari C.G.; Tandri C.C.; Situmorang G.R.	Ambarsari, Cahyani Gita (57211850895); Tandri, Chika Carnation (58612308600); Situmorang, Gerhard Reinaldi (57190001213)	57211850895; 58612308600; 57190001213	Urinary extracellular vesicles: Potential biomarkers for vesicoureteral reflux	2024	Vesicoureteral Reflux: From Diagnosis to Treatment	1	31	30	0	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85188558589&partnerID=40&md5=8a9d50d7da10ee591511aac119604866	Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Child Health, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; University of Nottingham, Nottingham, United Kingdom; Medical Technology Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Urology, Cipto Mangunkusumo Hospital, Jakarta, Indonesia	Ambarsari C.G., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Child Health, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, University of Nottingham, Nottingham, United Kingdom, Medical Technology Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tandri C.C., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Situmorang G.R., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Urology, Cipto Mangunkusumo Hospital, Jakarta, Indonesia	Vesicoureteral reflux (VUR) is characterized by the backward flow of urine from the bladder to the upper urinary tract, causing kidney damage if left untreated. However, the current diagnostic method, voiding cystourethrography (VCUG), is invasive, potentially risky, and may cause anxiety, especially for young patients and their caregivers. Urinary extracellular vesicles (uEVs) are small vesicles originating from the renal tubular system that carry lipids, proteins, and RNAs for intercellular communication and regulation. uEVs have emerged as promising human biofluid-derived biomarkers in various kidney diseases. This chapter explores the potential of uEVs as noninvasive biomarkers for diagnosing VUR, monitoring its progression, and determining the extent of kidney damage. Previously, serum inflammatory markers have been identified as factors associated with kidney fibrosis in reflux nephropathy, but these may simply be a reflection of systemic inflammation rather than of a specific condition. Meanwhile, current research on uEVs in VUR remains limited. One study has identified vitronectin, a uEV-derived protein, as a predictor of VUR induced by spinal cord injury (sensitivity = 80%, specificity = 82.9%, area under the curve (AUC) = 0.795). Another study, focusing on pediatric VUR, showed that patients with kidney fibrosis had significantly higher urinary neutrophil gelatinaseassociated lipocalin (uNGAL) values than those without kidney fibrosis (1.49 ng/mL vs. 0.58 ng/mL, p < 0.001). However, apart from kidney fibrosis, uNGAL also increases in the contexts of AKI and pediatric urinary tract infections, indicating that uNGAL is not specific as a single marker for VUR. These findings highlight the importance of identifying biomarkers derived from entities, such as uEVs, that are specific to the urinary system and are not affected by systemic factors In summary, uEVs offer crucial insights into urinary tract processes and have broad potential for diagnosing, treating, and forecasting kidney and urinary tract diseases, including VUR. Future studies to test their role should encompass larger sample sizes, standardized protocols, and rigorous validation. © 2024 Nova Science Publishers, Inc. All rights reserved.	Diagnostic; Fibrosis; Invasive; Kidney damage; Urinary tract			Nova Science Publishers, Inc.		979-889113505-5; 979-889113444-7		Book chapter	#N/A	#N/A	#N/A	View
320	Laurentius A.; Siagian S.N.	Laurentius, Andrea (57213147353); Siagian, Sisca Natalia (57214134720)	57213147353; 57214134720	Management of arrhythmia in chronic heart failure	2024	Pathophysiology, Risk Factors, and Management of Chronic Heart Failure	295	309	14	0	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85198408116&doi=10.1016%2fB978-0-12-822972-9.00040-7&partnerID=40&md5=396514226b291e19c64371b1addc7ae4	Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; National Cardiovascular Center Harapan Kita, Jakarta, Indonesia	Laurentius A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Siagian S.N., National Cardiovascular Center Harapan Kita, Jakarta, Indonesia	Management of chronic heart failure has been much more complex due to emergence of challenge in the treatment of heart failure and the underlying etiology simultaneously. The presence of arrhythmia may have adverse effects on long-term cardiac remodeling. Arrhythmia in chronic heart failure is exacerbated by overstimulation of neurohormonal system, which causes oxidative stress, inflammation, electrolyte imbalance, aggravating risk of increased arrhythmogenesis. As increase in QRS and QT prolongation predispose arrhythmogenesis, various types of tachyarrhythmia require guideline in the management to be specifically tailored to heart failure patients, such as adenosine in terminating supraventricular tachycardia, beta blocker for atrial fibrillation in heart failure, or class 1C antiarrhythmic medication for stable ventricular tachycardia. Furthermore, dysfunction of pacemaker nodes favors and needs arrhythmia complication. Patients with heart failure who developed arrhythmias present major artificial pacemaker installed with resynchronization mode, resolving conduction block in strained heart tissues. Understanding pathophysiology of arrhythmia classification in heart failure may assist in choosing appropriate management for patients, with increase in quality of life in these patients and reducing rate of morbidity and mortality. © 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.	Arrhythmia; cardiac remodeling; chronic heart failure; electrocardiographic features; management; pathophysiology; sudden cardiac death			Elsevier		978-012822972-9; 978-012823111-1		Book chapter	#N/A	#N/A	#N/A	View
345	Kartini D.; Dini M.A.R.	Kartini, Diani (57215490523); Dini, Merlynda Ayu Rara (58967752200)	57215490523; 58967752200	Pediatric Graves’ Disease: Surgical Interventions in a Single Institution – A Comprehensive Case Series	2024	Indian Journal of Otolaryngology and Head and Neck Surgery				0	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85198985493&doi=10.1007%2fs12070-024-04902-6&partnerID=40&md5=b5188397511d88f316b994673a623652	Division of Oncology Surgery, Department of Surgery, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Diponegoro Street Number 71, Jakarta, 10430, Indonesia	Kartini D., Division of Oncology Surgery, Department of Surgery, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Diponegoro Street Number 71, Jakarta, 10430, Indonesia; Dini M.A.R., Division of Oncology Surgery, Department of Surgery, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Diponegoro Street Number 71, Jakarta, 10430, Indonesia	Introduction: Graves’ disease (GD) is the most common cause of hyperthyroidism in children and adolescents. Data regarding pediatric GD in Indonesia are limited and pose challenges to diagnosing and treating the patients. In many aspects the clinical presentation of GD in children and adolescents resembles that of the adult population. There are three treatments for pediatric GD: anti-thyroid drugs, radioiodine ablation, and thyroidectomy. Although surgery is gaining acceptance as the definitive first-line treatment for children with GD, several studies examining pediatric populations have shown high complication rates. This study aims to describe a series of pediatric GD cases from a tertiary care center over an eight-year period. Presentation of Cases: Retrospective data of five patients with hyperthyroidism diagnosed with GD between 2014 and 2022 were reviewed. Clinical presentation, diagnosis, therapies, and short-term postoperative outcomes of GD were analyzed. All five GD patients presented with neck lumps. Low TSH levels and elevated FT4 levels were found in all patients preoperatively. Total thyroidectomy was performed in all patients, while one patient had lymphadenectomy concurrently. Histopathologic examination confirmed a diagnosis of GD in all patients. All patients in this study experienced postoperative complications such as hoarseness, while only three patients had hypocalcemia as a complication. Discussion: Total thyroidectomy in pediatric patients remains challenging. The euthyroid condition in patient prior to surgery is recommended to avoid the risk of thyroid storm during surgery, but a few studies have revealed that there is no difference in outcomes for hyperthyroid individuals. Close postoperative surveillance for complications of total thyroidectomy is necessary. Conclusions: Results of this study showed that pediatric GD patients had the same symptoms of hyperthyroidism as adults with all patients complained of neck lumps. Total thyroidectomy is the definitive therapy for GD in pediatrics as well as in adults. The minority of patients will experience transient and benign morbidities, with hoarseness of the voice being the most common transient postoperative morbidity. In performing total thyroidectomy, meticulous surgery and good anatomical recognition are required to avoid postoperative complications. So that, follow-up of post-total thyroidectomy in pediatric GD patients needs to be done. © Association of Otolaryngologists of India 2024.	Graves’ Disease; Pediatric; Total Thyroidectomy			Springer	22313796			Article	Q3	284	15653	View
346	Widodo W.; Oppusunggu P.P.; Enggra N.	Widodo, Wahyu (57208941551); Oppusunggu, Patar Parmonangan (59207945200); Enggra, Nesta (57222656758)	57208941551; 59207945200; 57222656758	Fingertip injuries: Does administration of antibiotics give benefits? A double-blind randomized controlled trial	2024	European Journal of Orthopaedic Surgery and Traumatology				0	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85197711304&doi=10.1007%2fs00590-024-04009-2&partnerID=40&md5=96fc7ee1267e70a17d6ff2295c195463	Department of Orthopaedics and Traumatology, Cipto Mangunkusumo Hospital, Jakarta – Medical Faculty, Universitas Indonesia, Jakarta, Indonesia; Department of Orthopaedics and Traumatology, Tangerang Hospital, West Java, Tangerang, Indonesia	Widodo W., Department of Orthopaedics and Traumatology, Cipto Mangunkusumo Hospital, Jakarta – Medical Faculty, Universitas Indonesia, Jakarta, Indonesia; Oppusunggu P.P., Department of Orthopaedics and Traumatology, Tangerang Hospital, West Java, Tangerang, Indonesia; Enggra N., Department of Orthopaedics and Traumatology, Cipto Mangunkusumo Hospital, Jakarta – Medical Faculty, Universitas Indonesia, Jakarta, Indonesia	Purpose: Adequate debridement and defect closure is an important treatment in fingertip injuries in addition to administration of antibiotic. However, administration of anitibiotics remains controversial whether it necessary for fingertip injuries that have been treated with adequate debridement and defect closure. The goal of study is to assess the differences of infection rate between subgroups with administration of antibiotics and without antibiotic in FTI treated by debridement and simple defect closure. Methods: The study design was a double-blind randomized clinical trial. Data collection was carried out at Cipto Mangunkusumo General Hospital, Jakarta and Tangerang Regency Hospital, Banten, in July 2022–February 2023. The target population of this study were adult patients with Fingertip injuries that treated by debridement and simple defect closures with antibiotics administration and without antibiotic. Infection was assessed at day-7, 14, and 21 follow-up. Results: There were 31 FTI subjects with 41 fingers affected. The number of male subjects was 27 people and female subjects 4 people. The most affected finger was the little finger (12 fingers, 30.8%), with most type of Allen classification was type IV (18 fingers, 43.90%), most procedure performed was primary suture (24 fingers, 58.54%). 15 subjects randomized to antibiotic group and 16 subjects to no-antibiotic group. There was 1 subject of antibiotic group and 1 subject of no-antibiotic group has infection. There are no significant differences between two groups. Conclusion: There were no significant differences of infection rate between antibiotics administration and without antibiotic in FTI cases that treated by debridement and simple defect closures. © The Author(s), under exclusive licence to Springer-Verlag France SAS, part of Springer Nature 2024.	Antibiotics; Debridement; Defect closure; Fingertip injury; Infection			Springer Nature	16338065			Article	Q1	720	6864	View
347	Mendel B.	Mendel, Brian (57221914088)	57221914088	Congenital heart diseases	2024	Pathophysiology, Risk Factors, and Management of Chronic Heart Failure	235	241	6	0	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85198448113&doi=10.1016%2fB978-0-12-822972-9.00008-0&partnerID=40&md5=48038dbfbb12ec5abee34bb259721448	Department of Cardiology and Vascular Medicine, Sultan Sulaiman Government Hospital, North Sumatera, Indonesia; Faculty of Medicine, University of Indonesia, Jakarta, Indonesia	Mendel B., Department of Cardiology and Vascular Medicine, Sultan Sulaiman Government Hospital, North Sumatera, Indonesia, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia	Heart failure (HF) is the final common pathway of all cardiac pathologies. However, conventional description of HF spectrum is always within the settings of ischemic, hypertensive, valvular, and myopathic diseases presented to the underappreciation of the essential subgroups of patients with HF, those with corrected or uncorrected congenital heart diseases (CHDs). Moreover, increasing research recognition of HF in patients with CHD in the shifting epidemiology from pediatric to adult in the CHD populations due to the advance in surgical and medical management had not been balanced with adequate expansion in both research and public health practices. Thus, the objective of this chapter was to focus on how the pathophysiology of patients with CHD progresses into HF with the intention of highlighting important gaps in the knowledge.; HF can develop early in life prior to one or more residual substrates from underlying or surgically corrected cardiac defect result in accumulated cardiac pressure and volume overload. Understanding of complex cardiac and respiratory physiology in CHD pathophysiology is extremely essential in managing these patients. © 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.	Congenital heart disease; heart failure; pressure overload; systemic right ventricle; volume overload			Elsevier		978-012822972-9; 978-012823111-1		Book chapter	#N/A	#N/A	#N/A	View
366	Danpanichkul P.; Uawithya E.; Lopimpisuth C.; Sukphutanan B.; Kulthamrongsri N.; Aboona M.B.; Duangsonk K.; Lau S.; Simadibrata D.M.; Daggag H.; Wallace M.B.; Wijarnpreecha K.	Danpanichkul, Pojsakorn (57963658100); Uawithya, Ekdanai (58906254500); Lopimpisuth, Chawin (57212483647); Sukphutanan, Banthoon (58532932000); Kulthamrongsri, Narathorn (57468252000); Aboona, Majd B. (57751393600); Duangsonk, Kwanjit (6507430994); Lau, Sirimas (59205599900); Simadibrata, Daniel M. (57202134322); Daggag, Hinda (24757982600); Wallace, Michael B. (7401942875); Wijarnpreecha, Karn (56324138000)	57963658100; 58906254500; 57212483647; 58532932000; 57468252000; 57751393600; 6507430994; 59205599900; 57202134322; 24757982600; 7401942875; 56324138000	Early-onset pancreatic cancer and associated metabolic risk factors in the Middle East and North Africa: A 20-year analysis of the Global Burden of Disease Study	2024	Indian Journal of Gastroenterology				0	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85197649354&doi=10.1007%2fs12664-024-01626-x&partnerID=40&md5=9ec9e5b63ea902200745eb45f1938637	Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, United States; Immunology Unit, Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; Faculty of Medicine Siriraj Hospital, Mahidol University, Nakhon Pathom, Thailand; Department of Internal Medicine, University of Miami, Jackson Memorial Hospital, Miami, FL, United States; Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Nakhon Pathom, Thailand; Department of Cardiovascular Medicine, Mayo Clinic Arizona, Phoenix, AZ, United States; Department of Internal Medicine, University of Arizona College of Medicine, Phoenix, AZ, United States; Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; Department of Internal Medicine, Metrowest Medical Center, Framingham, MA, United States; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States; Imperial College London Diabetes Centre, Abu Dhabi, United Arab Emirates; Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL, United States; Department of Gastroenterology, Sheikh Shakhbout Medical City, Abu Dhabi, United Arab Emirates; Division of Gastroenterology and Hepatology, Department of Medicine, University of Arizona College of Medicine, Phoenix, AZ, United States; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Banner University Medical Center, Phoenix, AZ, United States; BIO5 Institute, University of Arizona College of Medicine-Phoenix, Phoenix, AZ, United States	Danpanichkul P., Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, United States, Immunology Unit, Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; Uawithya E., Faculty of Medicine Siriraj Hospital, Mahidol University, Nakhon Pathom, Thailand; Lopimpisuth C., Department of Internal Medicine, University of Miami, Jackson Memorial Hospital, Miami, FL, United States; Sukphutanan B., Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; Kulthamrongsri N., Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Nakhon Pathom, Thailand, Department of Cardiovascular Medicine, Mayo Clinic Arizona, Phoenix, AZ, United States; Aboona M.B., Department of Internal Medicine, University of Arizona College of Medicine, Phoenix, AZ, United States; Duangsonk K., Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; Lau S., Department of Internal Medicine, Metrowest Medical Center, Framingham, MA, United States; Simadibrata D.M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States; Daggag H., Imperial College London Diabetes Centre, Abu Dhabi, United Arab Emirates; Wallace M.B., Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL, United States, Department of Gastroenterology, Sheikh Shakhbout Medical City, Abu Dhabi, United Arab Emirates; Wijarnpreecha K., Division of Gastroenterology and Hepatology, Department of Medicine, University of Arizona College of Medicine, Phoenix, AZ, United States, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Banner University Medical Center, Phoenix, AZ, United States, BIO5 Institute, University of Arizona College of Medicine-Phoenix, Phoenix, AZ, United States	Background and Objective: Early-onset pancreatic cancer (EOPC) is associated with poor prognosis and high disease burden. Metabolic risk factors such as diabetes and obesity are considered risk factors of EOPC. Recently, there has been an increasing number of EOPCs worldwide. However, the analysis of EOPC, including its metabolic risk factors, in the Middle East and North Africa (MENA) region has not been fully addressed. Methods: Data from the Global Burden of Disease Study between 2000 and 2019 was used to analyze the prevalence, incidence, deaths and disability-adjusted life years (DALYs) associated with EOPC and its metabolic risk factors. The analysis further categorized the data based on countries, income status and sex and examined the annual percentage change (APC). Results: Approximately 2800 cases, 2400 deaths and 114,000 DALYs were attributable to EOPC in the MENA region. The incidence (APC + 3.42%), death (APC + 0.73%) and DALYs (APC + 3.23%) rates of EOPC increased. In addition, the death and DALY rates of EOPC attributable to obesity and diabetes increased. High and upper-middle-income countries exhibited a higher burden of EOPC than lower-income countries. Conclusion: Over the past two decades, the burden of EOPC and its associated metabolic risk factors has increased. There is an urgent need for region-wide policy development, including screening methods and risk factor reduction, to mitigate the high and rising burden of EOPC in the MENA region. Graphical Abstract: (Figure presented.). © Indian Society of Gastroenterology 2024.	Early-onset cancer; Epidemiology; Middle East; Pancreatic cancer	Virgo Inc	Michael B. Wallace: consulting: Cosmo/Aries Pharmaceuticals, Verily, Boston Scientific, Endiatx, InterVenn, AlphaMed UAE, Fujifilm; research grants: Fujifilm, Boston Scientific, Olympus, Medtronic, Ninepoint Medical, Cosmo/Aries Pharmaceuticals; stock/stock options: Virgo Inc. Consulting on behalf of Mayo Clinic: Boston Scientific. Microtek General payments/Minor Food and Beverage: Boston Scientif	Springer	2548860			Article	Q3	395	12596	View
378	Putra J.; Rahadiani N.; Carreon C.K.	Putra, Juan (56346127500); Rahadiani, Nur (16426455700); Carreon, Chrystalle Katte (55932892900)	56346127500; 16426455700; 55932892900	Survey Data and Experience from a Pediatric Pathology Workshop in Indonesia: Understanding Practice Needs and Utility of Outreach Teachings	2024	Fetal and Pediatric Pathology				0	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85198546451&doi=10.1080%2f15513815.2024.2377651&partnerID=40&md5=d3969178c8867c58e951498dc4af8148	Department of Pathology, Boston Children’s Hospital and Harvard Medical School, Boston, MA, United States; Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Putra J., Department of Pathology, Boston Children’s Hospital and Harvard Medical School, Boston, MA, United States; Rahadiani N., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Carreon C.K., Department of Pathology, Boston Children’s Hospital and Harvard Medical School, Boston, MA, United States	Objective: We aimed to share the post-workshop survey results of a pediatric pathology course held in Jakarta, Indonesia. Methods: Questionnaires were distributed to participants; responses from practicing pathologists and pathologists-in-training were analyzed. Results: The respondents (107 pathologists of 143 attendees) were predominantly female (83.2%) and 31–60 years of age (77.5%). Over half (71.7%) signed out pediatric and perinatal specimens but only a third (34.3%) were comfortable handling such cases. Most (70.0%) felt that their exposure to pediatric and perinatal cases during their training was inadequate. All respondents thought that the workshop was helpful, and would highly recommend it to their colleagues. Post-workshop, the respondents claimed expansion of differential diagnoses (49.5%) and better understanding of what to include in pathology reports (41.1%). Conclusions: Our experience affirms the need for subspecialty courses to address training gaps in developing countries. Post-workshop surveys are helpful in determining actionable deficiencies and effectiveness of outreach teachings. © 2024 Taylor & Francis Group, LLC.	Indonesia; outreach teaching; Pediatric pathology; Southeast Asia; workshop			Taylor and Francis Ltd.	15513815		38989819	Article	Q3	323	14409	View
379	Andres E.B.; Yo V.; Balasubramanian I.; Poco L.; Ozdemir S.; Manalo M.F.; Rahman R.; Putranto R.; Zu W.W.M.; Palat G.; Mariam L.; Tuong P.N.; Malhotra C.	Andres, Ellie Bostwick (26634860400); Yo, Valen (59212797700); Balasubramanian, Ishwarya (59177715400); Poco, Louisa (57210392354); Ozdemir, Semra (35553994400); Manalo, Maria Fidelis (55826067700); Rahman, Rubaiyat (59212997600); Putranto, Rudi (56074051000); Zu, Wah Wah Myint (57217486003); Palat, Gayatri (12800879800); Mariam, Lubna (57226118551); Tuong, Pham Nguyen (57218932132); Malhotra, Chetna (24338706400)	26634860400; 59212797700; 59177715400; 57210392354; 35553994400; 55826067700; 59212997600; 56074051000; 57217486003; 12800879800; 57226118551; 57218932132; 24338706400	Opioid Access among Advanced Cancer Patients in Low- and Middle-Income Countries in Asia	2024	Journal of Pain and Symptom Management				0	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85198063377&doi=10.1016%2fj.jpainsymman.2024.06.020&partnerID=40&md5=32aefaea8399aa74169e407769012213	Lien Centre for Palliative Care (E.B.A., V.Y., I.B., L.P., S.O., C.M.), Duke-NUS Medical School, Singapore, Singapore; Section of Supportive Oncology & Palliative Care, The Medical City (M.F.M.), Pasig, Philippines; Bangabandhu Sheikh Mujib Medical University (R.R.), Dhaka, Bangladesh; Rumah Sakit Umum Pusat Nasional (R.P.), Dr. Cipto Mangunkusumo, Jakarta, Indonesia; Division of Psychosomatic and Palliative Medicine (R.P.), Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Clinical Research Division (W.W.M.Z.), Yangon General Hospital, Yangon, Myanmar; Department of Palliative Medicine (G.P.), MNJ Institute of Oncology and Regional Cancer Centre Hyderabad, India; Department of Radiation Oncology, National Institute of Cancer Research and Hospital (L.M.), Dhaka, Bangladesh; Oncology Center (P.N.T.), Hue Central Hospital, Hue, Hue City, Viet Nam	Andres E.B., Lien Centre for Palliative Care (E.B.A., V.Y., I.B., L.P., S.O., C.M.), Duke-NUS Medical School, Singapore, Singapore; Yo V., Lien Centre for Palliative Care (E.B.A., V.Y., I.B., L.P., S.O., C.M.), Duke-NUS Medical School, Singapore, Singapore; Balasubramanian I., Lien Centre for Palliative Care (E.B.A., V.Y., I.B., L.P., S.O., C.M.), Duke-NUS Medical School, Singapore, Singapore; Poco L., Lien Centre for Palliative Care (E.B.A., V.Y., I.B., L.P., S.O., C.M.), Duke-NUS Medical School, Singapore, Singapore; Ozdemir S., Lien Centre for Palliative Care (E.B.A., V.Y., I.B., L.P., S.O., C.M.), Duke-NUS Medical School, Singapore, Singapore; Manalo M.F., Section of Supportive Oncology & Palliative Care, The Medical City (M.F.M.), Pasig, Philippines; Rahman R., Bangabandhu Sheikh Mujib Medical University (R.R.), Dhaka, Bangladesh; Putranto R., Rumah Sakit Umum Pusat Nasional (R.P.), Dr. Cipto Mangunkusumo, Jakarta, Indonesia, Division of Psychosomatic and Palliative Medicine (R.P.), Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Zu W.W.M., Clinical Research Division (W.W.M.Z.), Yangon General Hospital, Yangon, Myanmar; Palat G., Department of Palliative Medicine (G.P.), MNJ Institute of Oncology and Regional Cancer Centre Hyderabad, India; Mariam L., Department of Radiation Oncology, National Institute of Cancer Research and Hospital (L.M.), Dhaka, Bangladesh; Tuong P.N., Oncology Center (P.N.T.), Hue Central Hospital, Hue, Hue City, Viet Nam; Malhotra C., Lien Centre for Palliative Care (E.B.A., V.Y., I.B., L.P., S.O., C.M.), Duke-NUS Medical School, Singapore, Singapore	Context: Most cancer-associated pain is experienced in low- and middle-income countries (LMICs) due to inequitable access to opioids. Objective: To determine opioid access as estimated by both patients and providers and to understand patient and facility-level factors influencing access among patients with advanced cancer in LMICs in Asia using the Behavioral Model of Health Services Use. Methods: The APPROACH cross-sectional study was conducted in seven LMICs in Asia, involving in-depth surveys with providers and advanced cancer patients. A hierarchical logistic regression model was used to assess predisposing (i.e. individual factors), enabling (i.e. health care system and facility-level resources) and need (i.e. pain severity) factors predicting opioid access. Results: Among patient participants (n=1,933), approximately 40% reported opioid use. Meanwhile 80% of facilities, as reported by providers, indicated at least half of their advanced cancer patients receive oral morphine prescriptions. Predisposing characteristics factored in the least in the model, with patient education positively associated with access (Odds ratio (OR): 1.01; 95% CI=1.00, 1.03). Facility-level enabling resources, factoring the most, included oral morphine prescription duration >14 days (OR: 1.27; 95% CI=1.05, 1.53) and the extent of physician palliative care training (extensive (>160 hours) OR: 3.95; CI=3.19, 4.88; basic (up to 40 hours) OR: 1.03; CI=1.03, 1.04). Patient need as indicated by greater pain severity predicted access (OR: 1.55; CI=1.47, 1.64). Conclusion: Study findings emphasize the importance of palliative care training—even a minimal amount—in supporting access to opioids for advanced cancer patients. This study also highlights pragmatic site-level policies, such as extended morphine prescription durations, enabling access. © 2024 American Academy of Hospice and Palliative Medicine	access; behavioral model of health services use; cancer; LMICs; opioids; palliative care			Elsevier Inc.	8853924		38964427	Article	Q1	1306	2700	View
402	La Distia Nora R.; Putera I.; Schrijver B.; Singh G.; Bakker M.; Riasanti M.; Edwar L.; Susiyanti M.; Aziza Y.; ten Berge J.C.E.M.; Rombach S.M.; van Hagen P.M.; Sitompul R.; Dik W.A.	La Distia Nora, Rina (56001881000); Putera, Ikhwanuliman (56485949000); Schrijver, Benjamin (36345029700); Singh, Gurmeet (57209127647); Bakker, Marleen (7101722384); Riasanti, Mei (57565527600); Edwar, Lukman (55695047800); Susiyanti, Made (19640377300); Aziza, Yulia (57214455776); ten Berge, Josianne C.E.M. (56601233400); Rombach, Saskia M. (58860662800); van Hagen, P. Martin (57210765646); Sitompul, Ratna (8312163900); Dik, Willem A. (6603280038)	56001881000; 56485949000; 36345029700; 57209127647; 7101722384; 57565527600; 55695047800; 19640377300; 57214455776; 56601233400; 58860662800; 57210765646; 8312163900; 6603280038	Ocular Tuberculosis Diagnosis Through Biomarkers: Clinical Relevance of Serum C1q and Whole Blood Interferon Gene Signature Score	2024	Ocular Immunology and Inflammation				0	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85196720125&doi=10.1080%2f09273948.2024.2368670&partnerID=40&md5=90e9ebb4b8293b16143edf21e828102d	Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Laboratory Medical Immunology, Department of Immunology, Erasmus University Medical Center, Rotterdam, Netherlands; Department of Ophthalmology, Erasmus University Medical Center, Rotterdam, Netherlands; Department of Internal Medicine Section Allergy & Clinical Immunology, Erasmus University Medical Center, Rotterdam, Netherlands; Department of Internal Medicine, Respirology and Critical Illness Division, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Pulmonary Diseases, Erasmus Medical Center, Rotterdam, Netherlands	La Distia Nora R., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Laboratory Medical Immunology, Department of Immunology, Erasmus University Medical Center, Rotterdam, Netherlands; Putera I., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Laboratory Medical Immunology, Department of Immunology, Erasmus University Medical Center, Rotterdam, Netherlands, Department of Ophthalmology, Erasmus University Medical Center, Rotterdam, Netherlands, Department of Internal Medicine Section Allergy & Clinical Immunology, Erasmus University Medical Center, Rotterdam, Netherlands; Schrijver B., Laboratory Medical Immunology, Department of Immunology, Erasmus University Medical Center, Rotterdam, Netherlands; Singh G., Department of Internal Medicine, Respirology and Critical Illness Division, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Bakker M., Department of Pulmonary Diseases, Erasmus Medical Center, Rotterdam, Netherlands; Riasanti M., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Edwar L., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Susiyanti M., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Aziza Y., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; ten Berge J.C.E.M., Department of Ophthalmology, Erasmus University Medical Center, Rotterdam, Netherlands; Rombach S.M., Department of Internal Medicine Section Allergy & Clinical Immunology, Erasmus University Medical Center, Rotterdam, Netherlands; van Hagen P.M., Laboratory Medical Immunology, Department of Immunology, Erasmus University Medical Center, Rotterdam, Netherlands, Department of Internal Medicine Section Allergy & Clinical Immunology, Erasmus University Medical Center, Rotterdam, Netherlands; Sitompul R., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Dik W.A., Laboratory Medical Immunology, Department of Immunology, Erasmus University Medical Center, Rotterdam, Netherlands	Purpose: To assess the clinical relevance of pathophysiology-based biomarkers, specifically serum C1q and whole blood interferon gene signature score (IGSS), in ocular tuberculosis (OTB) diagnosis by conducting an integrative analysis of clinical presentations and treatment response. Methods: This retrospective cohort study analysed data from 70 patients with suspected OTB at a tertiary care uveitis practice in Indonesia. Serum C1q levels and whole blood IGSS were quantified. Patients were categorized into four quadrants based on their biomarker profiles: quadrant 1 (high C1q & low IGSS), quadrant 2 (high C1q & high IGSS), quadrant 3 (low C1q & high IGSS), and quadrant 4 (low C1q & low IGSS). Characteristics of clinical presentations, work-up results, and treatment outcomes were explored according to the predefined quadrants. Results: We identified that the majority of OTB patients diagnosed with concurrent active pulmonary TB were in quadrant 1, 2, or 3 (20/23, 87.0%). Twenty-seven patients (27/47, 57.4%) with clinically undifferentiated uveitis were in quadrant 4 (p < 0.001). Among patients in quadrants 1, 2, and 3, completion of a full course of antitubercular treatment (ATT) was associated with a lower number of patients showing persistence or recurrence of ocular inflammation compared to those who were not fully treated with ATT (14.3% vs 85.7%, p = 0.001). Conclusions: Based on the analysis of clinical features and treatment outcomes, patients with elevated levels of either or both serum C1q and whole blood IGSS may reflect active TB disease in the eye, necessitating full ATT management. © 2024 Taylor & Francis Group, LLC.	Biomarker; C1q; diagnosis; ocular tuberculosis; type 1 interferon			Taylor and Francis Ltd.	9273948			Article	Q1	805	5924	View
403	Grijsen M.L.; Hamers R.L.	Grijsen, Marlous L. (25225113700); Hamers, Raph L. (23034345900)	25225113700; 23034345900	Scombroid fish poisoning	2024	JEADV Clinical Practice				0	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85190415283&doi=10.1002%2fjvc2.414&partnerID=40&md5=da875391670703c7d8c657e6945f6d38	Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom	Grijsen M.L., Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom; Hamers R.L., Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom	[No abstract available]	mackerel; Scombridae; scombroid fish poisoning; skin rash; toxin-induced; tuna			John Wiley and Sons Inc	27686566			Note	#N/A	#N/A	#N/A	View

Publikasi Scopus 2024 per tanggal 31 Juli 2024 (607 artikel)