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Tarwadi; Pambudi S.; Sriherwanto C.; Sasangka A.N.; Bowolaksono A.; Wijayadikusumah A.R.; Zeng W.; Rachmawati H.; Kartasasmita R.E.; Kazi M. |
Tarwadi (24169949500); Pambudi, Sabar (37115903900); Sriherwanto, Catur (57217729443); Sasangka, Ayu N. (59230814400); Bowolaksono, Anom (57205093224); Wijayadikusumah, Acep R. (57194976916); Zeng, Weiguang (7203023746); Rachmawati, Heni (8601757900); Kartasasmita, Rahmana E. (7801610135); Kazi, Mohsin (56921753300) |
24169949500; 37115903900; 57217729443; 59230814400; 57205093224; 57194976916; 7203023746; 8601757900; 7801610135; 56921753300 |
Inclusion of TAT and NLS sequences in lipopeptide molecules generates homogenous nanoparticles for gene delivery applications |
2024 |
International Journal of Pharmaceutics |
662 |
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124492 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85199330549&doi=10.1016%2fj.ijpharm.2024.124492&partnerID=40&md5=9c578d41204bfdb56f0acbef272c4748 |
Research Center for Vaccines and Drugs, National Agency for Research and Innovation (BRIN), Building 610-611 Puspiptek Area, Banten, Tangerang Selatan, 15314, Indonesia; PT Indomabs Biosantika Utama, Gedung Technology Business and Innovation Centre (TBIC), Pengasinan, Gunung Sindur, Kabupaten Bogor, Jawa Barat, 16340, Indonesia; Research Centre for Applied Microbiology, National Agency for Research and Innovation (BRIN), Building 610-611 Puspiptek Area, Banten, Tangerang Selatan, 15314, Indonesia; Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jawa Barat, Depok, 16424, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Jawa Barat, Depok, 16424, Indonesia; Research and Development Division, PT. Bio Farma, Jl. Pasteur No 28 Bandung, Jawa Barat, 40161, Indonesia; Peter Doherty Institute, The University of Melbourne, 792 Elizabeth St, Melbourne, 3000, VIC, Australia; School of Pharmacy, Bandung Institute of Technology, Jl. Ganesa 10 Bandung, Jawa Barat, 40132, Indonesia; Research Centre of Nano Sciences and Nanotechnology, Bandung Institute of Technology, Jl. Ganesa 10 Bandung 40132, Jawa Barat, Indonesia; Department of Pharmaceutics, College of Pharmacy, POBOX-2457, King Saud University, Riyadh, 11451, Saudi Arabia |
Tarwadi, Research Center for Vaccines and Drugs, National Agency for Research and Innovation (BRIN), Building 610-611 Puspiptek Area, Banten, Tangerang Selatan, 15314, Indonesia, PT Indomabs Biosantika Utama, Gedung Technology Business and Innovation Centre (TBIC), Pengasinan, Gunung Sindur, Kabupaten Bogor, Jawa Barat, 16340, Indonesia; Pambudi S., Research Center for Vaccines and Drugs, National Agency for Research and Innovation (BRIN), Building 610-611 Puspiptek Area, Banten, Tangerang Selatan, 15314, Indonesia; Sriherwanto C., Research Centre for Applied Microbiology, National Agency for Research and Innovation (BRIN), Building 610-611 Puspiptek Area, Banten, Tangerang Selatan, 15314, Indonesia; Sasangka A.N., Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jawa Barat, Depok, 16424, Indonesia; Bowolaksono A., Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Jawa Barat, Depok, 16424, Indonesia; Wijayadikusumah A.R., Research and Development Division, PT. Bio Farma, Jl. Pasteur No 28 Bandung, Jawa Barat, 40161, Indonesia; Zeng W., Peter Doherty Institute, The University of Melbourne, 792 Elizabeth St, Melbourne, 3000, VIC, Australia; Rachmawati H., School of Pharmacy, Bandung Institute of Technology, Jl. Ganesa 10 Bandung, Jawa Barat, 40132, Indonesia, Research Centre of Nano Sciences and Nanotechnology, Bandung Institute of Technology, Jl. Ganesa 10 Bandung 40132, Jawa Barat, Indonesia; Kartasasmita R.E., School of Pharmacy, Bandung Institute of Technology, Jl. Ganesa 10 Bandung, Jawa Barat, 40132, Indonesia; Kazi M., Department of Pharmaceutics, College of Pharmacy, POBOX-2457, King Saud University, Riyadh, 11451, Saudi Arabia |
Purposes: The objective of this study is to develop a versatile gene carrier based on lipopeptides capable of delivering genetic material into target cells with minimal cytotoxicity. Methods: Two lipopeptide molecules, palmitoyl-CKKHH and palmitoyl-CKKHH-YGRKKRRQRRR-PKKKRKV, were synthesized using solid phase peptide synthesis and evaluated as transfection agents. Physicochemical characterization of the lipopeptides included a DNA shift mobility assay, particle size measurement, and transmission electron microscopy (TEM) analysis. Cytotoxicity was assessed in CHO-K1 and HepG2 cells using the MTT assay, while transfection efficiency was determined by evaluating the expression of the green fluorescent protein-encoding gene. Results: Our findings demonstrate that the lipopeptides can bind, condense, and shield DNA from DNase degradation. The inclusion of the YGRKKRRQRRR sequence, a transcription trans activator, and the PKKKRKV sequence, a nuclear localization signal, imparts desirable properties. Lipopeptide-based TAT-NLS/DNA nanoparticles exhibited stability for up to 20 days when stored at 6–8 °C, displaying uniformity with a compact size of approximately 120 nm. Furthermore, the lipopeptides exhibited lower cytotoxicity compared to the poly-L-lysine. Transfection experiments revealed that protein expression mediated by the lipopeptide occurred at a charge ratio ranging from 4.0 to 8.0. Conclusion: These results indicate that the lipopeptide, composed of a palmitoyl alkyl chain and TAT and NLS sequences, can efficiently condense and protect DNA, form stable and uniform nanoparticles, and exhibit promising characteristics as a potential gene carrier with minimal cytotoxicity. © 2024 Elsevier B.V. |
Cytotoxicity; Homogenous nanoparticle; Lipopeptide; NLS; TAT; Transfection |
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King Saud University, KSU; Agency for Research and Innovation; University of Melbourne, UNIMELB, (12/II.7/HK/2023); BRIN, (RSP2024R301) |
We extend our gratitude to Professor David Jackson for his invaluable contribution to lipopeptide synthesis conducted at the Peter Doherty Institute Laboratory, The University of Melbourne, Australia. We also express our appreciation to the support of Research and Innovation Program for Advancement of Indonesia (RIIM) Project Number of 12/II.7/HK/2023 at the Agency for Research and Innovation (BRI |
Elsevier B.V. |
3785173 |
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Article |
Q1 |
906 |
4937 |
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10 |
Atmodiwirjo P.; Bangun K.; Rachadian Ramadan M.; Tania V.; Djohan M.; Ralena N.A.; Amanda N.F. |
Atmodiwirjo, Parintosa (57203016968); Bangun, Kristaninta (36902624600); Rachadian Ramadan, Mohamad (57222667572); Tania, Vika (57394760300); Djohan, Michael (59205590300); Ralena, Nadhira Anindita (57214093149); Amanda, Nadira Fildza (59205390500) |
57203016968; 36902624600; 57222667572; 57394760300; 59205590300; 57214093149; 59205390500 |
Does Free Fibular Flap Reconstruction Affect the Quality of Life in Pediatric Patients with Various Extend of Mandible Defects? |
2024 |
Journal of Craniofacial Surgery |
35 |
5 |
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1411 |
1416 |
5 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85197653880&doi=10.1097%2fSCS.0000000000010347&partnerID=40&md5=95fd58446d12f8870a0550e28ee2edd3 |
Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Indonesia; Reconstructive Microsurgery and Oncoplasty Section, Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Dr. Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Cleft and Craniofacial Centre, Dr. Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Atmodiwirjo P., Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Indonesia, Reconstructive Microsurgery and Oncoplasty Section, Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Dr. Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Bangun K., Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Indonesia, Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Cleft and Craniofacial Centre, Dr. Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rachadian Ramadan M., Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Indonesia, Reconstructive Microsurgery and Oncoplasty Section, Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Dr. Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Tania V., Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Indonesia, Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Cleft and Craniofacial Centre, Dr. Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Djohan M., Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Indonesia; Ralena N.A., Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Indonesia; Amanda N.F., Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Indonesia |
Background: The long-term outcomes in pediatric patients with various extents of mandible defects have not been well-documented. Methods: A retrospective case series in which this study looked at pediatric patients under the age of 13 who had mandibular reconstruction with free fibular flap and had not received another operation in the previous 6 months. The eating, swallowing, speech function, and quality of life are evaluated with EORTC QLQ-H&N35 after the mandible growth spurt has occurred. Results: A total of 7 patients were included in this study with operation ages ranging from 6 years 1 month to 12 years 2 months. The etiology of malignant tumors was found in 2 patients and benign tumors in 5 patients. The mandibular defect distribution consists of 1 class Ic, 1 class II, 2 class IIc, 2 class III, and 1 class IVc. All patients reported no swallowing or speech difficulties. However, transient eating trouble was seen in 1 patient due to the extensive defect size that causes tooth loss. Only 1 patient received dental rehabilitation. The patients displayed an overall good quality of life with an average score of 2.857. Conclusions: Free fibular flap for mandibular reconstruction in children who have not reached their mandibular growth peak have a satisfying outcome, both in their function and quality of life. © 2024 Lippincott Williams and Wilkins. All rights reserved. |
Fibular flap; mandible; pediatric; quality of life; reconstruction |
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Lippincott Williams and Wilkins |
10492275 |
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Article |
Q2 |
396 |
12572 |
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12 |
Kreshanti P.; Supriadi S.; Kekalih A.; Rahyussalim A.J.; Priosoeryanto B.P.; Noviana D.; Hatibie M.J.; Sukasah C.L.; Aditya A. |
Kreshanti, Prasetyanugraheni (36192866200); Supriadi, Sugeng (16040272500); Kekalih, Aria (55633562200); Rahyussalim, Ahmad Jabir (59175656700); Priosoeryanto, Bambang Pontjo (6603282841); Noviana, Deni (6505909761); Hatibie, Mendy Juniaty (59205710000); Sukasah, Chaula Luthfia (57218391534); Aditya, Andi (59205317400) |
36192866200; 16040272500; 55633562200; 59175656700; 6603282841; 6505909761; 59205710000; 57218391534; 59205317400 |
Novel Design of Interlocking 3-Dimensional Miniplate in Mandibular Angle Fractures: An In Vitro Study |
2024 |
Journal of Craniofacial Surgery |
35 |
5 |
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1591 |
1596 |
5 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85197609249&doi=10.1097%2fSCS.0000000000010372&partnerID=40&md5=b5a77886414f48b5c9e9489a5154c45d |
Doctoral Program in Medical Sciences Faculty of Medicine Universitas Indonesia, Department of Surgery, Universitas Indonesia, Depok, Indonesia; Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Universitas Indonesia, Depok, Indonesia; Departments of Community Medicine, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Departments of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, Indonesia; Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, Indonesia; Cleft and Craniofacial Center, United States; Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Division of Veterinary Pathology, School of Veterinary Medicine and Biomedical Sciences, Ipb University, Bogor, Indonesia; Division of Surgery and Radiology, School of Veterinary Medicine and Biomedical Sciences, Ipb University, Bogor, Indonesia; Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Faculty of Medicine, Sam Ratulangi University, Manado, Indonesia |
Kreshanti P., Doctoral Program in Medical Sciences Faculty of Medicine Universitas Indonesia, Department of Surgery, Universitas Indonesia, Depok, Indonesia, Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Universitas Indonesia, Depok, Indonesia, Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, Indonesia, Cleft and Craniofacial Center, United States; Supriadi S., Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, Indonesia, Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, Indonesia; Kekalih A., Departments of Community Medicine, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Rahyussalim A.J., Departments of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Priosoeryanto B.P., Division of Veterinary Pathology, School of Veterinary Medicine and Biomedical Sciences, Ipb University, Bogor, Indonesia; Noviana D., Division of Surgery and Radiology, School of Veterinary Medicine and Biomedical Sciences, Ipb University, Bogor, Indonesia; Hatibie M.J., Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Faculty of Medicine, Sam Ratulangi University, Manado, Indonesia; Sukasah C.L., Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Universitas Indonesia, Depok, Indonesia; Aditya A., Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, Indonesia |
The evolution of osteosynthesis has led to the development of novel miniplate designs, including 3-dimensional (3D) miniplates, which offer improved biomechanical stability. However, mandible fractures resulting from the high impact have a complex fracture configuration. Hence, the authors developed interlocking 3D miniplate to overcome the difficulty in miniplate and screw placement to avoid critical anatomic structures, that is, dental roots and nerve, while still providing stability for the fracture fragments. The interlocking 3D miniplates can be formed according to the specific needs by adjusting the horizontal and vertical cross struts configuration. This study describes a design process of interlocking 3D miniplates and evaluates biomechanical performance compared to standard miniplates. Finite element analysis was performed to evaluate the design's stress state using human and goat mandible models under various loading conditions. After the authors, established that our design was feasible for fabrication, the authors developed the prototype for biomechanical testing. Biomechanical testing was conducted on 10 goat mandibles to compare stability and displacement under various load between the interlocking 3D miniplate and the standard miniplate configuration. Biomechanical testing revealed reduced displacement in all directions with the interlocking 3D miniplate compared to the standard miniplate. Furthermore, there was a significant difference in all loads in the buccal-lingual displacement (P<0.05). The novel interlocking 3D miniplate design shows an adequate ability to provide stability for fixation for mandibular fractures, as evidenced by finite element analysis and biomechanical testing. Further research is necessary to validate these findings and explore the clinical application of interlocking 3D miniplates in mandibular fracture management. Copyright © 2024 by Mutaz B. Habal, MD. |
Biomechanics; experimental; finite element analysis; implants; internal fixator; mandibular fracture |
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PUTI; Universitas Indonesia, UI, (NKB-592/UN2.RST/HKP.05.00/2020); Universitas Indonesia, UI |
This work was supported by PUTI Doktoral from Universitas Indonesia. Grant number: NKB-592/UN2.RST/HKP.05.00/2020. |
Lippincott Williams and Wilkins |
10492275 |
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Article |
Q2 |
396 |
12572 |
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22 |
Habiburrahman M.; Sutopo S.; Sarkowi W.K. |
Habiburrahman, Muhammad (57204537114); Sutopo, Stefanus (57749107800); Sarkowi, Widya Khairunnisa (58485303400) |
57204537114; 57749107800; 58485303400 |
Plausible use of citicoline as an adjuvant in central nervous system infections: A case report and review of the literature |
2024 |
World Academy of Sciences Journal |
6 |
4 |
e39 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85195882024&doi=10.3892%2fwasj.2024.254&partnerID=40&md5=dc2840fd07b17d5dc90d220da79c121a |
Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, 10430, Indonesia; Dr. Cipto Mangunkusumo Hospital, Central Jakarta, DKI Jakarta, 10430, Indonesia; Tebet Subdistrict Public Hospital, South Jakarta, DKI Jakarta, 12810, Indonesia; Faculty of Medicine, Imperial College London, London, SW7 2AZ, United Kingdom; School of Infection and Immunity, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, United Kingdom; Faculty of Medicine, IPB University, West Java, Bogor, 16680, Indonesia; Faculty of Medicine, Universitas Indonesia, Salemba Raya Street No. 6, Senen Subdistrict, Central Jakarta, DKI Jakarta, 10430, Indonesia |
Habiburrahman M., Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, 10430, Indonesia, Dr. Cipto Mangunkusumo Hospital, Central Jakarta, DKI Jakarta, 10430, Indonesia, Tebet Subdistrict Public Hospital, South Jakarta, DKI Jakarta, 12810, Indonesia, Faculty of Medicine, Imperial College London, London, SW7 2AZ, United Kingdom, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street No. 6, Senen Subdistrict, Central Jakarta, DKI Jakarta, 10430, Indonesia; Sutopo S., Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, 10430, Indonesia, Dr. Cipto Mangunkusumo Hospital, Central Jakarta, DKI Jakarta, 10430, Indonesia, School of Infection and Immunity, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, United Kingdom, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street No. 6, Senen Subdistrict, Central Jakarta, DKI Jakarta, 10430, Indonesia; Sarkowi W.K., Faculty of Medicine, Imperial College London, London, SW7 2AZ, United Kingdom, Faculty of Medicine, IPB University, West Java, Bogor, 16680, Indonesia |
Citicoline has been widely used for the treatment of neurological conditions of the central nervous system (CNS), and exhibit potential for infection management, providing anti-inflammatory, antiviral, antioxidant and neuroprotective properties. The present study describes the case of a 50-year-old male patient co-infected with suspected tuberculosis and COVID-19 affecting the CNS who was treated with citicoline. The study aimed to raise clinical questions and initiate a comprehensive literature review. It also aimed to explore the plausible benefits of the use of citicoline in restoring consciousness and alleviating neurological symptoms in CNS infections. In the literature review, eight studies, including two quasi-experimental studies, five literature reviews, and one case report were found to be relevant to the case of the patient described herein, and they suggested that citicoline demonstrated partial protection against cerebral malaria, prevented encephalitis sequelae when immediately administered, and inhibited coronavirus replication. Additionally, six studies reported the potential of citicoline in the treatment of neurological conditions, such as ethambutol-induced optic neuropathy, stroke, head trauma and CNS infections caused by cerebral malaria and COVID-19, compared to standard therapy. Citicoline shows promise as an adjuvant therapy for neurological complications associated with CNS infections. © 2024 Spandidos Publications. All rights reserved. |
adjuvant therapy; central nervous system infections; citicoline; evidence-based case report; neurological disorders |
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Spandidos Publications |
26322900 |
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Article |
Q3 |
317 |
14612 |
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27 |
Atmodiwirjo P.; Ramadan M.R.; Sapphira E.; Djohan M.; Ralena N.A.; Amanda N.F. |
Atmodiwirjo, Parintosa (57203016968); Ramadan, Mohamad R. (57222667572); Sapphira, Elrica (59213850300); Djohan, Michael (59205590300); Ralena, Nadhira A. (57214093149); Amanda, Nadira F. (59205390500) |
57203016968; 57222667572; 59213850300; 59205590300; 57214093149; 59205390500 |
Fluorescence Intensity between Standard versus Diluted Indocyanine Green to Evaluate Flap Perfusion in Rats |
2024 |
Plastic and Reconstructive Surgery - Global Open |
12 |
7 |
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e5948 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85198189408&doi=10.1097%2fGOX.0000000000005948&partnerID=40&md5=e878745493a992780d45de0fbaa4be30 |
Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Atmodiwirjo P., Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Ramadan M.R., Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Sapphira E., Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Djohan M., Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Ralena N.A., Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Amanda N.F., Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Summary: The ideal dose for indocyanine green (ICG) has not been established yet, although 5 mg per mL is widely accepted for free flap evaluation. Due to its high price and rarity in developing countries, this preliminary study aimed to find the lowest concentration of ICG without reducing the fluorescence quality read by near-infrared camera in animal models. An experimental study was conducted on 25 Wistar rats divided into five groups based on the injected ICG, which was in 5 mg per mL, 3.75 mg per mL, 2.5 mg per mL, 1.25 mg per mL, and 0.5 mg per mL concentrations. The epigastric flap was elevated and confirmed to be vital on the fifth day. Upon confirmation, bolus IV injection of ICG was given via the tail, and the flap was read using near-infrared camera. The 25 different videos are randomized and rated individually in a blind manner by five microsurgeons, chosen beforehand. The videos are evaluated with a scoring system ranging from 0 to 4, assessing fluorescence visibility and flap vasculature. Nonetheless, the intraclass correlation coefficient is 0.779. There was no difference between standard and diluted ICG concentrations to evaluate flap perfusion. The 2.5 mg per mL concentration of ICG was the most favorable. This finding is not clinically relevant for application in human subjects yet. However, this study shows promising results for further usage of ICG in daily practice at a lower cost. © 2024 Lippincott Williams and Wilkins. All rights reserved. |
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Lippincott Williams and Wilkins |
21697574 |
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Article |
Q2 |
671 |
7496 |
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33 |
Saputri S.; Alodia B.; Habiburrahman M. |
Saputri, Silvana (57212475016); Alodia, Beryl (57208311898); Habiburrahman, Muhammad (57204537114) |
57212475016; 57208311898; 57204537114 |
Neonatal hyperglycaemia in extremely preterm and extremely low birth weight infants: A report of a rare case and a review of the literature |
2024 |
World Academy of Sciences Journal |
6 |
4 |
37 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85195862140&doi=10.3892%2fwasj.2024.252&partnerID=40&md5=ad838e867e6357a5aa840aaf3a45bfd1 |
Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, 10430, Indonesia; Dr. Cipto Mangunkusumo Hospital, Central Jakarta, DKI Jakarta, 10430, Indonesia; Bunda Mother and Child Hospital, Central Jakarta, DKI Jakarta, 10350, Indonesia; Community Health Centre Mampang Prapatan, South Jakarta, DKI Jakarta, 12720, Indonesia; Faculty of Medicine, Imperial College London, London, SW7 2AZ, United Kingdom |
Saputri S., Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, 10430, Indonesia, Dr. Cipto Mangunkusumo Hospital, Central Jakarta, DKI Jakarta, 10430, Indonesia, Bunda Mother and Child Hospital, Central Jakarta, DKI Jakarta, 10350, Indonesia; Alodia B., Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, 10430, Indonesia, Dr. Cipto Mangunkusumo Hospital, Central Jakarta, DKI Jakarta, 10430, Indonesia, Community Health Centre Mampang Prapatan, South Jakarta, DKI Jakarta, 12720, Indonesia; Habiburrahman M., Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, 10430, Indonesia, Dr. Cipto Mangunkusumo Hospital, Central Jakarta, DKI Jakarta, 10430, Indonesia, Faculty of Medicine, Imperial College London, London, SW7 2AZ, United Kingdom |
Neonatal hyperglycaemia poses risks, and the efficacy of insulin therapy is uncertain, warranting comprehensive research and guidelines. The present study reports the case of an extremely preterm neonate with an extremely low birth weight (ELBW; <1,000 g) admitted to the neonatal intensive care unit (NICU) due to recurrent hyperglycaemic episodes (peak level, 465 mg/dl) with transient hypoglycaemia on the first day of life. The mother, a 31-year-old primiparous woman, had gestational hypertension and preeclampsia, resulting in neonatal distress at birth and the need for positive pressure ventilation for stabilisation. The condition of the baby remained stable in the NICU following resuscitation. The case described herein details the management of a neonate facing multiple stresses and metabolic challenges, including grade IV hyaline membrane disease, grade II necrotising enterocolitis and a patent foramen ovale with good heart contractility. The initial laboratory findings revealed pancytopenia. At 1 h of life, the neonate experienced hypoglycaemia (33 mg/dl), treated with a 10% bolus dextrose infusion and continuous parenteral nutrition. Glucose infusion rate (GIR) adjustments followed local guidelines. Cardiovascular support with dobutamine and dopamine addressed the low blood pressure. Subsequently, the neonate developed hyperglycaemia, requiring insulin therapy and GIR adjustments. By close monitoring and promptly intervening, the authors were able to achieve stable blood glucose levels using insulin boluses (0.1 U) and adjusting the GIR to 10.9 mg/kg body weight (BW)/min. Stable glycaemia was attained by the 4th day prior to referral, with a GIR of 12.4 mg/kg BW/min. The case in the present study highlights the challenges of managing extremely preterm infants with ELBW and emphasises effective resuscitation and NICU interventions. It was hypothesised that her refractory hyperglycaemia was caused by her underlying extremely premature neonatal condition, including inadequate insulin response, gluconeogenesis, reduced glucose transporter levels, insufficient protein intake affecting insulin-like growth factor-1 release, immature pancreas development and stress-related hormonal responses. © 2024 Spandidos Publications. All rights reserved. |
clinical outcomes; extremely low birth weight; hypoglycaemia; neonatal hyperglycaemia; premature |
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Spandidos Publications |
26322900 |
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Article |
Q3 |
317 |
14612 |
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37 |
Subahar R.; Hadyansyah R.; Aldilla R.; Yulhasri Y.; Winita R.; Dwira S.; El Bayani G.F. |
Subahar, Rizal (6508197883); Hadyansyah, Rizqy (59229205600); Aldilla, Rachmanin (59229088300); Yulhasri, Yulhasri (57225180520); Winita, Rawina (57220782528); Dwira, Surya (57204110404); El Bayani, Gulshan Fahmi (57195935050) |
6508197883; 59229205600; 59229088300; 57225180520; 57220782528; 57204110404; 57195935050 |
Toxicity of 6-gingerol and Cymbopogon citratus against Pediculus humanus capitis De Geer (Phthiraptera: Pediculidae): Mortality, detoxifying enzymes, and morphological ultrastructure alterations in lice |
2024 |
Research in Veterinary Science |
177 |
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105364 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85199254708&doi=10.1016%2fj.rvsc.2024.105364&partnerID=40&md5=5a3d6ac21849f052aa2759615983adda |
Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Medical Doctor Program, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Department of Medical Physiology and Biophysics, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia |
Subahar R., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Hadyansyah R., Medical Doctor Program, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Aldilla R., Medical Doctor Program, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Yulhasri Y., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Winita R., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Dwira S., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; El Bayani G.F., Department of Medical Physiology and Biophysics, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia |
Pediculus humanus capitis (head louse), which causes pediculosis capitis, remains a global health concern. Plant products are efficient alternative pediculicides for treating the human ectoparasite P. h. capitis which is resistant to permethrin. The study evaluates the toxicity and mechanisms of 6-gingerol and Cymbopogon citratus leaf extract on P. h. capitis. Pediculus humanus capitis adult stages were exposed to three different dosages of 6-gingerol and C. citratus crude leaf extract on filter sheets for 5, 10, and 30 min, respectively. The biochemical approach was used to assess the activity of detoxifying enzymes including acetylcholinesterase (AChE), glutathione S-transferase (GST), and oxidase. Scanning electron microscope (SEM) was used to investigate the ultrastructure of the morphological body of lice. After 30 min, 6-gingerol and C. citratus leaf extract killed P. h. capitis completely. Bioassay periods significantly affected lice mortality (P < 0.05). The LC50 values for 6-gingerol and C. citratus extract were 1.79 μg/cm2 and 25.0 μg/cm2, respectively. 6-Gingerol and C. citratus leaf extract significantly lower AChE and GST activity (P < 0.05). Cymbopogon citratus also caused morphological ultrastructure changes in P. h. capitis, including an irregularly formed head, thorax, abdominal respiratory spiracles, and belly. 6-Gingerol and C. citratus leaf extracts could be used as an alternate pediculicide to decrease P. h. capitis populations. © 2024 |
6-gingerol; Cymbopogon citratus; Detoxification enzyme; Morphological ultrastructure of lice; Pediculus humanus capitis |
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Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia; Universitas Indonesia, UI, (HIBAH PUTI Q2 2020) |
Funding text 1: This research was funded by the Directorate of Research and Community Service at the Universitas Indonesia (grant no. HIBAH PUTI Q2 2020).This research was funded by theThe Directorate of Research and Development at the Universitas Indonesia (grant number HIBAH PUTI Q2 2020). The authors would like to thank the Head of the Department of Parasitology and the Head of the Department o |
Elsevier B.V. |
345288 |
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Article |
Q1 |
577 |
8960 |
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38 |
Paramita N.; Santoso D.I.S.; Nusdwinuringtyas N.; Rasmin M.; Kartinah N.T.; Jusman S.W.A.; Abdullah M.; Tinduh D.; Widjanantie S.C.; Harini M.; Sianipar I.R.; Nugraha B.; Gutenbrunner C.; Widaty S. |
Paramita, Nurul (57205715266); Santoso, Dewi Irawati Soeria (6604001213); Nusdwinuringtyas, Nury (56608215500); Rasmin, Menaldi (15754578700); Kartinah, Neng Tine (57192914846); Jusman, Sri Widia A. (36518792100); Abdullah, Murdani (7103393434); Tinduh, Damayanti (57193005920); Widjanantie, Siti Chandra (58681887200); Harini, Melinda (57222385190); Sianipar, Imelda Rosalyn (55486707100); Nugraha, Boya (34168038300); Gutenbrunner, Christoph (7006250778); Widaty, Sandra (57208261546) |
57205715266; 6604001213; 56608215500; 15754578700; 57192914846; 36518792100; 7103393434; 57193005920; 58681887200; 57222385190; 55486707100; 34168038300; 7006250778; 57208261546 |
The Delphi Method: Developing a Telerehabilitation Practice Guideline for Patients in Indonesia with Long COVID |
2024 |
International Journal of Telerehabilitation |
16 |
1 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85197663646&doi=10.5195%2fijt.2024.6610&partnerID=40&md5=5a43680e2e88f8a5f5f4155c07e75025 |
Doctoral Program in Medical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Physiology and Biophysics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Pulmonology and Respiratory Medicine, Persahabatan National Respiratory Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Airlangga University, Surabaya, Indonesia; Department of Physical Medicine and Medical Rehabilitation, Dr. Soetomo General Hospital, Surabaya, Indonesia; Department of Physical Medicine and Rehabilitation, Persahabatan National Respiratory Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Rehabilitation and Sport Medicine, Hannover Medical School, Hannover, 30625, Germany; Hannover Rehabilitation Services & Science Consulting, Hannover, 30627, Germany; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Paramita N., Doctoral Program in Medical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Physiology and Biophysics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Santoso D.I.S., Department of Medical Physiology and Biophysics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Nusdwinuringtyas N., Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rasmin M., Department of Pulmonology and Respiratory Medicine, Persahabatan National Respiratory Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kartinah N.T., Department of Medical Physiology and Biophysics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Jusman S.W.A., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Abdullah M., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Tinduh D., Faculty of Medicine, Airlangga University, Surabaya, Indonesia, Department of Physical Medicine and Medical Rehabilitation, Dr. Soetomo General Hospital, Surabaya, Indonesia; Widjanantie S.C., Department of Physical Medicine and Rehabilitation, Persahabatan National Respiratory Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Harini M., Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sianipar I.R., Department of Medical Physiology and Biophysics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Nugraha B., Department of Rehabilitation and Sport Medicine, Hannover Medical School, Hannover, 30625, Germany, Hannover Rehabilitation Services & Science Consulting, Hannover, 30627, Germany; Gutenbrunner C., Department of Rehabilitation and Sport Medicine, Hannover Medical School, Hannover, 30625, Germany; Widaty S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Telerehabilitation has the potential to help expand the reach of rehabilitation intervention. An online questionnaire-based Delphi method set out to develop a telerehabilitation guideline for patients in Indonesia with Long COVID. A Delphi panel comprised of 24 experts was selected from all relevant disciplines. Over two rounds of Delphi testing, panelists gave opinions and indicated their level of agreement with each recommendation. Key elements of consensus for a telerehabilitation guideline for patients with Long COVID includes: the benefit of telerehabilitation, types of rehabilitation intervention needed, methods of intervention, criteria for home-based self-exercise training, set-up of rehabilitation prescription, exercise monitoring, evaluation of rehabilitation intervention and duration of rehabilitation intervention. Further research is needed to determine the feasibility and effectiveness of this guideline. © 2024, University Library System, University of Pittsburgh. All rights reserved. |
Delphi method; Guideline; Long COVID; Rehabilitation; Telerehabilitation |
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Universitas Indonesia, UI, (NKB-592/UN2.RST/HKP.05.00/2022); Universitas Indonesia, UI |
The authors wish to thank all experts who participated in the study as panelists. The authors would like to thank Universitas Indonesia for funding this research through PUTI Grant with contract number NKB-592/UN2.RST/HKP.05.00/2022. |
University Library System, University of Pittsburgh |
19452020 |
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Article |
Q1 |
900 |
4989 |
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51 |
Harahap Y.; Mulyadi C.A.; Muliawan H.S.; Wahab H.A. |
Harahap, Yahdiana (16480400300); Mulyadi, Callista Andinie (57208649574); Muliawan, Hary Sakti (57203644653); Wahab, Habibah A. (6603194195) |
16480400300; 57208649574; 57203644653; 6603194195 |
Determination of warfarin in volumetric absorptive microsampling by liquid chromatography-tandem mass spectrometry |
2024 |
Heliyon |
10 |
14 |
e34500 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85198578196&doi=10.1016%2fj.heliyon.2024.e34500&partnerID=40&md5=0bdc51ef1ef771f3d1e21986ed3265ca |
Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Faculty of Military Pharmacy, the Republic of Indonesia Defense University, Bogor, 16810, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine-Universitas Indonesia Hospital, Depok, 16424, Indonesia; School of Pharmaceutical Sciences, Universiti Sains Malaysia, Pinang, Pulau, 11800, Malaysia |
Harahap Y., Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia, Faculty of Military Pharmacy, the Republic of Indonesia Defense University, Bogor, 16810, Indonesia; Mulyadi C.A., Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Muliawan H.S., Department of Cardiology and Vascular Medicine, Faculty of Medicine-Universitas Indonesia Hospital, Depok, 16424, Indonesia; Wahab H.A., School of Pharmaceutical Sciences, Universiti Sains Malaysia, Pinang, Pulau, 11800, Malaysia |
Objective: This study aims to develop and validate bioanalytical method for quantifying warfarin in VAMS samples using liquid chromatography tandem mass spectrometry (LC-MS/MS), directly implementing the method to patients receiving warfarin therapy. Methods: The UPLC-MS/MS method was developed and optimized, with quercetin as the internal standard. Sample preparation was carried out using protein precipitation with methanol-acetonitrile (1:3 v/v). Results: Chromatographic separation was achieved using Acquity® UPLC BEH C18 column with 0.1 % formic acid-acetonitrile-methanol (30:69:1 v/v) as mobile phase, in isocratic elution. Multiple Reaction Monitoring (MRM) detection was done using m/z values of 307.10 → 161.06 for warfarin and 301.03 → 150.98 for quercetin as internal standard, using Electrospray Ionization (ESI) negative ion source. The clinical application of the bioanalytical method was carried out on 25 patients receiving warfarin therapy at Universitas Indonesia Hospital and warfarin levels were well within the calibration range from 6.05 to 431.39 ng/mL. Conclusion: A novel method has been developed to analyze warfarin in VAMS samples. This method has been fully validated according to guideline from FDA 2022 and is linear in the range of 5–500 ng/mL and the value of r ≥ 0.9977, and successfully applied for the analysis of warfarin in VAMS samples of clinical patients. © 2024 |
LC-MS/MS; Therapeutic drug monitoring; Volumetric absorptive microsampling; Warfarin |
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Directorate of Research and Development Universitas Indonesia, (2023) |
This work was supported by the Directorate of Research and Development Universitas Indonesia, Depok, Indonesia under PUTI Grant 2023. |
Elsevier Ltd |
24058440 |
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Article |
Q1 |
609 |
8422 |
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53 |
Harzif A.K.; Pratamasari S.M.R.; Rumapea C.T.P.; Ummah N.; Mutia H.D.; Nurbaeti P.; Puspawardani A.R.; Wiweko B. |
Harzif, Achmad Kemal (57191493435); Pratamasari, Sarah Miriam Ratna (59229545400); Rumapea, Costan Tryono Parulian (59229420600); Ummah, Nafi’atul (58945649100); Mutia, Heidi Dewi (57214329625); Nurbaeti, Putri (58945649200); Puspawardani, Aisyah Retno (58944793100); Wiweko, Budi (43061741400) |
57191493435; 59229545400; 59229420600; 58945649100; 57214329625; 58945649200; 58944793100; 43061741400 |
The efficacy of luteal phase support in women with polycystic ovary syndrome following assisted reproductive technology: a systematic review |
2024 |
Middle East Fertility Society Journal |
29 |
1 |
40 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85199295889&doi=10.1186%2fs43043-024-00187-5&partnerID=40&md5=440e7d636e950a0e55a4289cbfcc5f68 |
Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Yasmin IVF Clinic dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Harzif A.K., Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Yasmin IVF Clinic dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Pratamasari S.M.R., Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rumapea C.T.P., Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Ummah N., Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Mutia H.D., Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Nurbaeti P., Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Puspawardani A.R., Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Wiweko B., Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Yasmin IVF Clinic dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: Polycystic ovary syndrome (PCOS) is a complex endocrine condition prevalent among a significant number of women during their reproductive years. Remarkably, 90–95% of women seeking infertility solutions due to anovulation are diagnosed with PCOS. Luteal phase support (LPS) is a crucial aspect of assisted reproductive technologies (ART). This systematic review aimed to evaluate the effectiveness of LPS in women with PCOS undergoing ART, with a focus on pregnancy rates as the primary endpoint. Materials and methods: A systematic search was conducted on EMBASE, PubMed, and Scopus databases without language restrictions. We searched for studies up to August 1, 2023. The search strategy used terms related to PCOS and LPS. Clinical trials and cohort studies involving infertile women with PCOS undergoing ART were included. The Risk of Bias 2 (ROB2) and the Newcastle-Ottawa Scale (NOS) tool were used to assess the risk of bias. Results: The review included five studies comprising a total of 818 patients. The studies used various ovulation induction medications, such as letrozole, clomiphene citrate, and human menopausal gonadotropin, in combination with different forms of progesterone for LPS (oral, intramuscular, and intravaginal). The overall results demonstrated inconsistent efficacy of LPS, with some studies showing significant improvements in pregnancy rates with LPS, while others showed no statistically significant difference. Conclusion: The systematic review suggests that LPS may improve pregnancy rates in women with PCOS undergoing ART. However, the effectiveness appears to be influenced by the choice of ovulation induction agent and the route of progesterone administration. Personalized treatment approaches considering patient response and emerging evidence are essential. © The Author(s) 2024. |
Luteal phase support; Polycystic ovary syndrome; Progesterone |
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Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia |
The authors sincerely thank the Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, for supporting this research. |
Springer Science and Business Media Deutschland GmbH |
11105690 |
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Review |
Q3 |
322 |
14459 |
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