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4 |
Rahayu D.; Meutia A.P.; Priyatini T.; Suratih N.M.D.; Maidarti M.; Harzif A.K.; Muharam R.; Pratama G. |
Rahayu, Deniswari (57208300474); Meutia, Alfa Putri (57203368133); Priyatini, Tyas (57192265423); Suratih, Ni Made Desy (26634582200); Maidarti, Mila (56320510400); Harzif, Achmad Kemal (57191493435); Muharam, R. (57191492732); Pratama, Gita (58162878900) |
57208300474; 57203368133; 57192265423; 26634582200; 56320510400; 57191493435; 57191492732; 58162878900 |
Association of hirsutism and anthropometric profiles with sexual dysfunction and anxiety levels in infertile Indonesian women with polycystic ovarian syndrome |
2024 |
Middle East Fertility Society Journal |
29 |
1 |
19 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85189636536&doi=10.1186%2fs43043-024-00178-6&partnerID=40&md5=22df206c1e005692cbf08891765f633a |
Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Urogynecology and Reconstructive Pelvic Surgery Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Reproductive Endocrinology Division, Department of Obstetrics and Gynecology, Persahabatan General Hospital, Jakarta, Indonesia; Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Yasmin IVF Clinic Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Rahayu D., Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Meutia A.P., Urogynecology and Reconstructive Pelvic Surgery Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Priyatini T., Urogynecology and Reconstructive Pelvic Surgery Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Suratih N.M.D., Reproductive Endocrinology Division, Department of Obstetrics and Gynecology, Persahabatan General Hospital, Jakarta, Indonesia; Maidarti M., Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Yasmin IVF Clinic Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Harzif A.K., Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Yasmin IVF Clinic Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Muharam R., Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Yasmin IVF Clinic Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Pratama G., Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Yasmin IVF Clinic Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Background: Hyperandrogenism is frequently found in polycystic ovary syndrome (PCOS) and contributes to physical manifestations like hirsutism and obesity, along with infertility. This condition can result in anxiety, depression, and body image disorders, potentially leading to sexual dysfunction. The objective of this investigation was to assess the correlation among hirsutism, anthropometric characteristics, sexual dysfunction, and anxiety levels among infertile Indonesian women diagnosed with PCOS. Methods: From December 2021 to December 2022, a cross-sectional study was undertaken involving 71 infertile women diagnosed with PCOS at Yasmin Clinic, Dr. Cipto Mangunkusumo General Hospital in Jakarta, Indonesia. Hirsutism was assessed using the modified Ferriman-Gallwey (mFG) score; the anthropometric profile was assessed using BMI and waist-to-hip ratio. The assessment of sexual dysfunction was conducted using the Female Sexual Function Index (FSFI) questionnaire, while the evaluation of anxiety levels utilized the HAM-A questionnaires. Results: In this study, it was discovered that 53.3% of subjects experienced sexual dysfunction. However, there was no statistically significant relationship between hirsutism, anthropometric profile, and sexual dysfunction score in infertile women with PCOS (p > 0.05). Analysis of the overall FSFI domain score revealed that lubrication and satisfaction were lower in obese patients (p = 0.02 and p = 0.03), but this did not contribute to an overall sexual dysfunction score. Also, we found that subjects who experienced sexual dysfunction had a higher anxiety score (p < 0.005), with correlation analysis showing that Ferriman-Gallwey (FG) scores have a significant positive correlation with anxiety. Conclusion: There is no correlation between hirsutism, anthropometric profile, and sexual dysfunction in infertile Indonesian women diagnosed with PCOS. However, hirsutism could play a role in causing anxiety in Indonesian PCOS women. Additional investigation is required, as female sexual function is an intricate subject. © The Author(s) 2024. |
Anthropometric profile; Hyperandrogenism; Infertility; PCOS; Polycystic ovarian syndrome; Sexual dysfunction |
contraceptive agent; follitropin; luteinizing hormone; adult; anthropometric parameters; anxiety disorder; arousal; Article; automation; body height; body mass; body weight; correlational study; cross-sectional study; dyspareunia; educational status; employee; employment status; female; female infertility; Female Sexual Function Index; Hamilton Anxiety Scale; hip circumference; hirsutism; human; hyperandrogenism; Indonesian; intra-abdominal fat; laboratory test; lubrication; major clinical study; modified ferriman gallwey score; obese patient; obesity; orgasm; ovary polycystic disease; patient satisfaction; pleasure; prevalence; questionnaire; sexual dysfunction; sexual function; skin disease assessment; social status; subcutaneous fat; transvaginal echography; unemployment; waist circumfe |
Indonesian Reproductive Medicine Research and Training Center; INAREPROMED; PUTI Saintekes 2020, (NKB-2278/UN.2) |
Funding text 1: The authors express gratitude to the Indonesian Reproductive Medicine Research and Training Center (INAREPROMED) and the teams at Yasmin Clinic and Rumah Sakit Dr. Cipto Mangunkusumo Hospital for their invaluable assistance and support throughout this study.; Funding text 2: This study received funding from the PUTI Saintekes 2020 grant, contract number NKB-2278/UN.2.RST/HKP.05.00. |
Springer Science and Business Media Deutschland GmbH |
11105690 |
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Article |
Q3 |
322 |
14459 |
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8 |
Sekarsari D.; Handoyono Q.F.; Amal M.Y.; Maharani M.A.P.; Hendriarto A. |
Sekarsari, Damayanti (57193342279); Handoyono, Quinta Febryani (58993286100); Amal, Mohamad Yanuar (57221702104); Maharani, Maria Angela Putri (58158818200); Hendriarto, Andra (57216821517) |
57193342279; 58993286100; 57221702104; 58158818200; 57216821517 |
Pediatric paraparesis: Radiological challenges in multidrug-resistant tuberculous spondylitis based on experience in Indonesia |
2024 |
Radiology Case Reports |
19 |
8 |
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3287 |
3293 |
6 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85193445919&doi=10.1016%2fj.radcr.2024.04.001&partnerID=40&md5=71f94f873b95af48e9249b2aeb5dc7ea |
Division of Pediatric Radiology, Department of Radiology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Department of Radiology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Department of Anatomic Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Department of Orthopedics and Traumatology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia |
Sekarsari D., Division of Pediatric Radiology, Department of Radiology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Handoyono Q.F., Department of Radiology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Amal M.Y., Division of Pediatric Radiology, Department of Radiology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Maharani M.A.P., Department of Anatomic Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia; Hendriarto A., Department of Orthopedics and Traumatology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No. 4, Senen, DKI Jakarta, Central Jakarta, Indonesia |
Multidrug-resistant tuberculous spondylitis is a global health issue, especially in developing nations, and non-specific symptoms lead to delay in identification, treatment, and potential disability in children. Radiology plays a crucial role in diagnosing tuberculous spondylitis, which in turn might lead to effective treatment, prevention of disability and improved patient outcomes. Our case involved a 20-month-old malnourished child presented with paraparesis, revealing a history of contact with parental multidrug-resistant tuberculosis. Multimodality radiological examinations, including conventional radiography, CT, and MRI revealed extensive disease of the spine with disc involvement, large paravertebral abscess, and kyphotic deformity which produced neurological deficits, necessitating both anti-tuberculosis regimen and surgical intervention. Radiological examinations have a pivotal role in diagnosing, evaluating and guiding timely management of multidrug-resistant tuberculous spondylitis. Prompt diagnosis of the condition is crucial in order to prevent potentially severe complications, which contribute significantly to morbidity. Our case demonstrated the importance of radiology in diagnosing extensive spine involvement of the disease causing neurological deficits. Furthermore, radiology also helps in managing tuberculous spondylitis to prevent future disability in a child patient of a developing country. This case highlights the crucial significance of radiological imaging in the diagnosis and management of pediatric tuberculous spondylitis in impoverished nations. The patient's complex medical history highlights the socioeconomic factors contributing to tuberculosis burden. Early and comprehensive radiological assessment, together with collaboration between radiologists and clinicians, is vital for timely intervention and improved outcomes in pediatric tuberculous spondylitis cases to prevent the impact of this debilitating disease on children. © 2024 |
Pediatric imaging; Tuberculosis; Tuberculous spondylitis |
abscess; Article; Babinski reflex; case report; child; clinical article; computer assisted tomography; erythrocyte sedimentation rate; female; gait; ground glass opacity; human; Indonesia; kyphosis; lung consolidation; lung fibrosis; malnutrition; multidrug resistant tuberculosis; muscle strength; neurologic examination; nuclear magnetic resonance imaging; paraplegia; physical examination; preschool child; radiodiagnosis; radiological parameters; tuberculous spondylitis |
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Elsevier Inc. |
19300433 |
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Article |
Q4 |
226 |
17897 |
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9 |
Tarwadi; Pambudi S.; Sriherwanto C.; Sasangka A.N.; Bowolaksono A.; Wijayadikusumah A.R.; Zeng W.; Rachmawati H.; Kartasasmita R.E.; Kazi M. |
Tarwadi (24169949500); Pambudi, Sabar (37115903900); Sriherwanto, Catur (57217729443); Sasangka, Ayu N. (59230814400); Bowolaksono, Anom (57205093224); Wijayadikusumah, Acep R. (57194976916); Zeng, Weiguang (7203023746); Rachmawati, Heni (8601757900); Kartasasmita, Rahmana E. (7801610135); Kazi, Mohsin (56921753300) |
24169949500; 37115903900; 57217729443; 59230814400; 57205093224; 57194976916; 7203023746; 8601757900; 7801610135; 56921753300 |
Inclusion of TAT and NLS sequences in lipopeptide molecules generates homogenous nanoparticles for gene delivery applications |
2024 |
International Journal of Pharmaceutics |
662 |
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124492 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85199330549&doi=10.1016%2fj.ijpharm.2024.124492&partnerID=40&md5=9c578d41204bfdb56f0acbef272c4748 |
Research Center for Vaccines and Drugs, National Agency for Research and Innovation (BRIN), Building 610-611 Puspiptek Area, Banten, Tangerang Selatan, 15314, Indonesia; PT Indomabs Biosantika Utama, Gedung Technology Business and Innovation Centre (TBIC), Pengasinan, Gunung Sindur, Kabupaten Bogor, Jawa Barat, 16340, Indonesia; Research Centre for Applied Microbiology, National Agency for Research and Innovation (BRIN), Building 610-611 Puspiptek Area, Banten, Tangerang Selatan, 15314, Indonesia; Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jawa Barat, Depok, 16424, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Jawa Barat, Depok, 16424, Indonesia; Research and Development Division, PT. Bio Farma, Jl. Pasteur No 28 Bandung, Jawa Barat, 40161, Indonesia; Peter Doherty Institute, The University of Melbourne, 792 Elizabeth St, Melbourne, 3000, VIC, Australia; School of Pharmacy, Bandung Institute of Technology, Jl. Ganesa 10 Bandung, Jawa Barat, 40132, Indonesia; Research Centre of Nano Sciences and Nanotechnology, Bandung Institute of Technology, Jl. Ganesa 10 Bandung 40132, Jawa Barat, Indonesia; Department of Pharmaceutics, College of Pharmacy, POBOX-2457, King Saud University, Riyadh, 11451, Saudi Arabia |
Tarwadi, Research Center for Vaccines and Drugs, National Agency for Research and Innovation (BRIN), Building 610-611 Puspiptek Area, Banten, Tangerang Selatan, 15314, Indonesia, PT Indomabs Biosantika Utama, Gedung Technology Business and Innovation Centre (TBIC), Pengasinan, Gunung Sindur, Kabupaten Bogor, Jawa Barat, 16340, Indonesia; Pambudi S., Research Center for Vaccines and Drugs, National Agency for Research and Innovation (BRIN), Building 610-611 Puspiptek Area, Banten, Tangerang Selatan, 15314, Indonesia; Sriherwanto C., Research Centre for Applied Microbiology, National Agency for Research and Innovation (BRIN), Building 610-611 Puspiptek Area, Banten, Tangerang Selatan, 15314, Indonesia; Sasangka A.N., Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jawa Barat, Depok, 16424, Indonesia; Bowolaksono A., Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Jawa Barat, Depok, 16424, Indonesia; Wijayadikusumah A.R., Research and Development Division, PT. Bio Farma, Jl. Pasteur No 28 Bandung, Jawa Barat, 40161, Indonesia; Zeng W., Peter Doherty Institute, The University of Melbourne, 792 Elizabeth St, Melbourne, 3000, VIC, Australia; Rachmawati H., School of Pharmacy, Bandung Institute of Technology, Jl. Ganesa 10 Bandung, Jawa Barat, 40132, Indonesia, Research Centre of Nano Sciences and Nanotechnology, Bandung Institute of Technology, Jl. Ganesa 10 Bandung 40132, Jawa Barat, Indonesia; Kartasasmita R.E., School of Pharmacy, Bandung Institute of Technology, Jl. Ganesa 10 Bandung, Jawa Barat, 40132, Indonesia; Kazi M., Department of Pharmaceutics, College of Pharmacy, POBOX-2457, King Saud University, Riyadh, 11451, Saudi Arabia |
Purposes: The objective of this study is to develop a versatile gene carrier based on lipopeptides capable of delivering genetic material into target cells with minimal cytotoxicity. Methods: Two lipopeptide molecules, palmitoyl-CKKHH and palmitoyl-CKKHH-YGRKKRRQRRR-PKKKRKV, were synthesized using solid phase peptide synthesis and evaluated as transfection agents. Physicochemical characterization of the lipopeptides included a DNA shift mobility assay, particle size measurement, and transmission electron microscopy (TEM) analysis. Cytotoxicity was assessed in CHO-K1 and HepG2 cells using the MTT assay, while transfection efficiency was determined by evaluating the expression of the green fluorescent protein-encoding gene. Results: Our findings demonstrate that the lipopeptides can bind, condense, and shield DNA from DNase degradation. The inclusion of the YGRKKRRQRRR sequence, a transcription trans activator, and the PKKKRKV sequence, a nuclear localization signal, imparts desirable properties. Lipopeptide-based TAT-NLS/DNA nanoparticles exhibited stability for up to 20 days when stored at 6–8 °C, displaying uniformity with a compact size of approximately 120 nm. Furthermore, the lipopeptides exhibited lower cytotoxicity compared to the poly-L-lysine. Transfection experiments revealed that protein expression mediated by the lipopeptide occurred at a charge ratio ranging from 4.0 to 8.0. Conclusion: These results indicate that the lipopeptide, composed of a palmitoyl alkyl chain and TAT and NLS sequences, can efficiently condense and protect DNA, form stable and uniform nanoparticles, and exhibit promising characteristics as a potential gene carrier with minimal cytotoxicity. © 2024 Elsevier B.V. |
Cytotoxicity; Homogenous nanoparticle; Lipopeptide; NLS; TAT; Transfection |
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King Saud University, KSU; Agency for Research and Innovation; University of Melbourne, UNIMELB, (12/II.7/HK/2023); BRIN, (RSP2024R301) |
We extend our gratitude to Professor David Jackson for his invaluable contribution to lipopeptide synthesis conducted at the Peter Doherty Institute Laboratory, The University of Melbourne, Australia. We also express our appreciation to the support of Research and Innovation Program for Advancement of Indonesia (RIIM) Project Number of 12/II.7/HK/2023 at the Agency for Research and Innovation (BRI |
Elsevier B.V. |
3785173 |
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Article |
Q1 |
906 |
4937 |
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10 |
Atmodiwirjo P.; Bangun K.; Rachadian Ramadan M.; Tania V.; Djohan M.; Ralena N.A.; Amanda N.F. |
Atmodiwirjo, Parintosa (57203016968); Bangun, Kristaninta (36902624600); Rachadian Ramadan, Mohamad (57222667572); Tania, Vika (57394760300); Djohan, Michael (59205590300); Ralena, Nadhira Anindita (57214093149); Amanda, Nadira Fildza (59205390500) |
57203016968; 36902624600; 57222667572; 57394760300; 59205590300; 57214093149; 59205390500 |
Does Free Fibular Flap Reconstruction Affect the Quality of Life in Pediatric Patients with Various Extend of Mandible Defects? |
2024 |
Journal of Craniofacial Surgery |
35 |
5 |
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1411 |
1416 |
5 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85197653880&doi=10.1097%2fSCS.0000000000010347&partnerID=40&md5=95fd58446d12f8870a0550e28ee2edd3 |
Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Indonesia; Reconstructive Microsurgery and Oncoplasty Section, Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Dr. Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Cleft and Craniofacial Centre, Dr. Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Atmodiwirjo P., Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Indonesia, Reconstructive Microsurgery and Oncoplasty Section, Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Dr. Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Bangun K., Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Indonesia, Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Cleft and Craniofacial Centre, Dr. Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rachadian Ramadan M., Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Indonesia, Reconstructive Microsurgery and Oncoplasty Section, Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Dr. Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Tania V., Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Indonesia, Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Cleft and Craniofacial Centre, Dr. Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Djohan M., Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Indonesia; Ralena N.A., Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Indonesia; Amanda N.F., Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery, Indonesia |
Background: The long-term outcomes in pediatric patients with various extents of mandible defects have not been well-documented. Methods: A retrospective case series in which this study looked at pediatric patients under the age of 13 who had mandibular reconstruction with free fibular flap and had not received another operation in the previous 6 months. The eating, swallowing, speech function, and quality of life are evaluated with EORTC QLQ-H&N35 after the mandible growth spurt has occurred. Results: A total of 7 patients were included in this study with operation ages ranging from 6 years 1 month to 12 years 2 months. The etiology of malignant tumors was found in 2 patients and benign tumors in 5 patients. The mandibular defect distribution consists of 1 class Ic, 1 class II, 2 class IIc, 2 class III, and 1 class IVc. All patients reported no swallowing or speech difficulties. However, transient eating trouble was seen in 1 patient due to the extensive defect size that causes tooth loss. Only 1 patient received dental rehabilitation. The patients displayed an overall good quality of life with an average score of 2.857. Conclusions: Free fibular flap for mandibular reconstruction in children who have not reached their mandibular growth peak have a satisfying outcome, both in their function and quality of life. © 2024 Lippincott Williams and Wilkins. All rights reserved. |
Fibular flap; mandible; pediatric; quality of life; reconstruction |
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Lippincott Williams and Wilkins |
10492275 |
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Article |
Q2 |
396 |
12572 |
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11 |
Harzif A.K.; Andyra A.F.; Sayogo A.; Ummah N.; Puspawardani A.R.; Nurbaeti P.; Wiweko B. |
Harzif, Achmad Kemal (57191493435); Andyra, Azizah Fitriayu (57438092800); Sayogo, Atikah (58945649000); Ummah, Nafi’atul (58945649100); Puspawardani, Aisyah Retno (58944793100); Nurbaeti, Putri (58945649200); Wiweko, Budi (43061741400) |
57191493435; 57438092800; 58945649000; 58945649100; 58944793100; 58945649200; 43061741400 |
Embryo response to aneuploidy through self-correction mechanism: a literature review |
2024 |
Middle East Fertility Society Journal |
29 |
1 |
16 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85188103317&doi=10.1186%2fs43043-024-00176-8&partnerID=40&md5=2ea59e3b8e555f1604df15976d449b84 |
Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Yasmin IVF Clinic Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Harzif A.K., Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Yasmin IVF Clinic Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Andyra A.F., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sayogo A., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ummah N., Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Puspawardani A.R., Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Nurbaeti P., Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wiweko B., Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Yasmin IVF Clinic Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Meiotic and mitotic errors often lead to aneuploidy and mosaicism. In this context, the self-correction mechanism enables the embryo to preferentially retain and preserve euploid cells through processes such as apoptosis, necrosis, or marginalization. This mechanism is thought to minimize the chance of genetic abnormalities during cell development. Materials and methods: A literature search for articles written in English from January 2013 to October 2023 was conducted on PubMed, EBSCO, and Scopus, using the keywords “self-correction,” “self-repair,” “aneuploidy,” “mosaicism,” and “embryo.” Results: A total of 308 articles were collected, out of which 5 retrospective and 1 prospective study were selected based on inclusion criteria. Discussions: Investigations showed that embryos remove chromosomally abnormal cells, supporting the self-correction mechanism. aCGH has been used in 4 studies to demonstrate the presence of self-correction in mosaic embryos. Furthermore, a higher relative viability of polyploidies than complex aneuploidies was observed, suggesting early discrimination against complex aneuploidy, particularly those arising from mitotic origins. However, there are doubts about the reliability of preimplantation genetic testing for aneuploidy at the blastocyst stage, as it may lead to a high rate of false positives and the discarding of "good" embryos. Conclusions: Studies showed a self-correction mechanism in human embryos through the ability to expel abnormal cells. Further investigation is needed to elucidate the underlying mechanisms and determine optimal strategies for preimplantation genetic testing to fully understand and optimize the use of self-correction mechanisms in embryo assessment and selection. © The Author(s) 2024. |
Aneuploidy; Embryo; Mosaicism; Self-correction; Self-repair |
aneuploidy; blastocyst; blastomere; chromosome 19; chromosome aberration; comparative genomic hybridization; cytogenetic analysis; embryo; embryo (anatomy); embryo biopsy; embryo development; false positive result; high throughput sequencing; human; human embryo; mosaicism; polymerase chain reaction; polyploidy; preimplantation genetic screening; Review; single nucleotide polymorphism array; trophectoderm; uniparental disomy; X chromosome |
Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia |
The authors would like to express gratitude to the Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, for supporting this study. |
Springer Science and Business Media Deutschland GmbH |
11105690 |
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Review |
Q3 |
322 |
14459 |
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12 |
Kreshanti P.; Supriadi S.; Kekalih A.; Rahyussalim A.J.; Priosoeryanto B.P.; Noviana D.; Hatibie M.J.; Sukasah C.L.; Aditya A. |
Kreshanti, Prasetyanugraheni (36192866200); Supriadi, Sugeng (16040272500); Kekalih, Aria (55633562200); Rahyussalim, Ahmad Jabir (59175656700); Priosoeryanto, Bambang Pontjo (6603282841); Noviana, Deni (6505909761); Hatibie, Mendy Juniaty (59205710000); Sukasah, Chaula Luthfia (57218391534); Aditya, Andi (59205317400) |
36192866200; 16040272500; 55633562200; 59175656700; 6603282841; 6505909761; 59205710000; 57218391534; 59205317400 |
Novel Design of Interlocking 3-Dimensional Miniplate in Mandibular Angle Fractures: An In Vitro Study |
2024 |
Journal of Craniofacial Surgery |
35 |
5 |
|
1591 |
1596 |
5 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85197609249&doi=10.1097%2fSCS.0000000000010372&partnerID=40&md5=b5a77886414f48b5c9e9489a5154c45d |
Doctoral Program in Medical Sciences Faculty of Medicine Universitas Indonesia, Department of Surgery, Universitas Indonesia, Depok, Indonesia; Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Universitas Indonesia, Depok, Indonesia; Departments of Community Medicine, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Departments of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, Indonesia; Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, Indonesia; Cleft and Craniofacial Center, United States; Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Division of Veterinary Pathology, School of Veterinary Medicine and Biomedical Sciences, Ipb University, Bogor, Indonesia; Division of Surgery and Radiology, School of Veterinary Medicine and Biomedical Sciences, Ipb University, Bogor, Indonesia; Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Faculty of Medicine, Sam Ratulangi University, Manado, Indonesia |
Kreshanti P., Doctoral Program in Medical Sciences Faculty of Medicine Universitas Indonesia, Department of Surgery, Universitas Indonesia, Depok, Indonesia, Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Universitas Indonesia, Depok, Indonesia, Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, Indonesia, Cleft and Craniofacial Center, United States; Supriadi S., Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, Indonesia, Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, Indonesia; Kekalih A., Departments of Community Medicine, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Rahyussalim A.J., Departments of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Priosoeryanto B.P., Division of Veterinary Pathology, School of Veterinary Medicine and Biomedical Sciences, Ipb University, Bogor, Indonesia; Noviana D., Division of Surgery and Radiology, School of Veterinary Medicine and Biomedical Sciences, Ipb University, Bogor, Indonesia; Hatibie M.J., Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Faculty of Medicine, Sam Ratulangi University, Manado, Indonesia; Sukasah C.L., Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Universitas Indonesia, Depok, Indonesia; Aditya A., Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, Indonesia |
The evolution of osteosynthesis has led to the development of novel miniplate designs, including 3-dimensional (3D) miniplates, which offer improved biomechanical stability. However, mandible fractures resulting from the high impact have a complex fracture configuration. Hence, the authors developed interlocking 3D miniplate to overcome the difficulty in miniplate and screw placement to avoid critical anatomic structures, that is, dental roots and nerve, while still providing stability for the fracture fragments. The interlocking 3D miniplates can be formed according to the specific needs by adjusting the horizontal and vertical cross struts configuration. This study describes a design process of interlocking 3D miniplates and evaluates biomechanical performance compared to standard miniplates. Finite element analysis was performed to evaluate the design's stress state using human and goat mandible models under various loading conditions. After the authors, established that our design was feasible for fabrication, the authors developed the prototype for biomechanical testing. Biomechanical testing was conducted on 10 goat mandibles to compare stability and displacement under various load between the interlocking 3D miniplate and the standard miniplate configuration. Biomechanical testing revealed reduced displacement in all directions with the interlocking 3D miniplate compared to the standard miniplate. Furthermore, there was a significant difference in all loads in the buccal-lingual displacement (P<0.05). The novel interlocking 3D miniplate design shows an adequate ability to provide stability for fixation for mandibular fractures, as evidenced by finite element analysis and biomechanical testing. Further research is necessary to validate these findings and explore the clinical application of interlocking 3D miniplates in mandibular fracture management. Copyright © 2024 by Mutaz B. Habal, MD. |
Biomechanics; experimental; finite element analysis; implants; internal fixator; mandibular fracture |
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PUTI; Universitas Indonesia, UI, (NKB-592/UN2.RST/HKP.05.00/2020); Universitas Indonesia, UI |
This work was supported by PUTI Doktoral from Universitas Indonesia. Grant number: NKB-592/UN2.RST/HKP.05.00/2020. |
Lippincott Williams and Wilkins |
10492275 |
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Article |
Q2 |
396 |
12572 |
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17 |
Julian J.; Adawiyah R.; Wahdini S. |
Julian, Julian (58677322900); Adawiyah, Robiatul (57208658742); Wahdini, Sri (57203684068) |
58677322900; 57208658742; 57203684068 |
BIOMOLECULAR ACTIVITY OF CRYPTOCOCCUS DURING CRYPTOCOCCOSIS: A REVIEW OF MOLECULAR INTERACTIONS OF CRYPTOCOCCUS WITH HUMAN IMMUNE SYSTEM AND BLOOD-BRAIN-BARRIER |
2024 |
African Journal of Infectious Diseases |
18 |
1 |
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11 |
22 |
11 |
0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85175528279&doi=10.21010%2fAjidv18i1.3&partnerID=40&md5=fd5671eda00d2ed2b911492e8e87a566 |
Master‟s Programme in biomedical science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Julian J., Master‟s Programme in biomedical science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Adawiyah R., Master‟s Programme in biomedical science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wahdini S., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Global mycosis is still a problem. One of these is the cryptococcal disease. A systemic mycosis brought on by Cryptococcus is called cryptococcosis. Host immunological conditions influence infection with Cryptococcosis. When environmental spores are inhaled by the host, the spores get to the lungs, an infection is created. Alveolar macrophages and other immune cells recognize Cryptococcus in the lung. The initial line of defense against pathogens in the phagolysosome is provided by alveolar macrophages found in the lungs. When the immune system is weak, Cryptococcus uses the evasion system as a molecular interaction with the immune system and persists in the lungs without causing any symptoms such as Factor Transcription, Cell masking, N-glycan structure, Extracellular molecule, and Antioxidant system. The evasion mechanism protects and makes Cryptococcus disseminate throughout the other organs, especially CNS. If Cryptococcus escapes against the host immune system, it will disseminate to other organs, especially Cerebrospinal System by Three mechanisms. There are Trojan Horse, Paracellular, and Transcellular interactions with Blood-Brain Barrier. Disease severity is determined by the Interaction between the host‟s immune system and the fungus. © 2024, African Traditional, Herbal Medicine Supporters Initiative. All rights reserved. |
Biomolecular Activity; Blood-Brain-Barrier; Cryptococcus; Fungal Disease; Immune Response |
fibrinogen; gamma interferon; glycan; Hermes antigen; interleukin 13; interleukin 1beta; nitric oxide; pathogen associated molecular pattern; reactive oxygen metabolite; toll like receptor; toll like receptor 4; toll like receptor 9; tumor necrosis factor; antioxidant activity; apoptosis; Article; blood brain barrier; CD4+ T lymphocyte; cryptococcosis; Cryptococcus neoformans; cytokine release; endocytosis; endoplasmic reticulum stress; Filobasidiella; human; immune response; immune system; innate immunity; lung alveolus macrophage; macrophage; molecular interaction; mycosis; nonhuman; oxidative stress; phagocytosis; phagolysosome; Th17 cell |
Ministry of Education, Culture, Research and Technology of the Republic of Indonesia, (NKB-0395/UN2.R3.1/HKP.05.00/2019) |
This manuscript was supported by “Publikasi Internasional Terindeks Tugas Akhir (PITTA A)” Research Grant 2019 from the Ministry of Education, Culture, Research and Technology of the Republic of Indonesia with grant number NKB-0395/UN2.R3.1/HKP.05.00/2019 |
African Traditional, Herbal Medicine Supporters Initiative |
20060165 |
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Article |
Q4 |
184 |
20019 |
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18 |
Mahfuz M.A.; Bramono I.A.; Rahman F.; Iriani D.; Harahap E.U.; Santoso R.B. |
Mahfuz, Muhammad Ainul (59073426400); Bramono, Ikhlas Arief (57191056767); Rahman, Fakhri (57194287568); Iriani, Dewi (59076552700); Harahap, Edward Usfie (57222296409); Santoso, Rachmat Budi (58715104300) |
59073426400; 57191056767; 57194287568; 59076552700; 57222296409; 58715104300 |
Laparoscopic Enucleation of an Extravesical Bladder Leiomyoma: A Case Report |
2024 |
African Journal of Urology |
30 |
1 |
25 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85192483652&doi=10.1186%2fs12301-024-00426-1&partnerID=40&md5=7f93ad7d489ff4bf54cab3b55523d42e |
Department of Urology, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo General Hospital, Jalan Pangeran Diponegoro No.71, Kenari, Jakarta Pusat, DKI Jakarta, Jakarta, 10430, Indonesia; Department of Urology, National Cancer Center – Dharmais Cancer Hospital, Jakarta, Indonesia; Department of Anatomical Pathology, National Cancer Center – Dharmais Cancer Hospital, Jakarta, Indonesia |
Mahfuz M.A., Department of Urology, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo General Hospital, Jalan Pangeran Diponegoro No.71, Kenari, Jakarta Pusat, DKI Jakarta, Jakarta, 10430, Indonesia; Bramono I.A., Department of Urology, National Cancer Center – Dharmais Cancer Hospital, Jakarta, Indonesia; Rahman F., Department of Urology, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo General Hospital, Jalan Pangeran Diponegoro No.71, Kenari, Jakarta Pusat, DKI Jakarta, Jakarta, 10430, Indonesia; Iriani D., Department of Anatomical Pathology, National Cancer Center – Dharmais Cancer Hospital, Jakarta, Indonesia; Harahap E.U., Department of Urology, National Cancer Center – Dharmais Cancer Hospital, Jakarta, Indonesia; Santoso R.B., Department of Urology, National Cancer Center – Dharmais Cancer Hospital, Jakarta, Indonesia |
Background: The management of leiomyomas, the most common benign mesenchymal tumours, remains highly debated. This case report presents the first laparoscopic enucleation of an extravesical bladder leiomyoma in Indonesia. Case presentation: A 48-year-old man presented with a lower abdominal mass. An abdominopelvic computed tomography scan showed a solid tumour mass in the right anterolateral wall of the bladder. To excise the mass, it was planned for the patient to undergo laparoscopic enucleation. The mass was removed intact, and a frozen section was taken to determine the malignancy profile. Histopathological examinations, followed by immunohistochemical examinations, confirmed the diagnosis of leiomyoma. Conclusions: Laparoscopic enucleation is a promising option for managing bladder masses. It is a minimally invasive procedure with optimal results for preserving bladder function. Prior to the surgery, imaging studies and cystoscopy examination are mandatory. © The Author(s) 2024. |
Extravesical bladder; Laparoscopic enucleation; Leiomyoma |
desmin (protein); eosin; hematoxylin; Ki 67 antigen; smooth muscle actin; vimentin; abdominal mass; adult; Article; bladder leiomyoma; bladder muscle; bladder wall; case report; cell proliferation; clinical article; computer assisted tomography; enucleation; extravesical bladder leiomyoma; frozen section; histopathology; human; human tissue; immunohistochemistry; laparoscopic surgery; lithotomy position; male; middle aged; peritoneum; solid malignant neoplasm; urachus |
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Springer Science and Business Media Deutschland GmbH |
11105704 |
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Article |
Q3 |
185 |
19959 |
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19 |
Siregar G.O.; Harianja M.; Adella J.; Krismawati H.; Sundari E.S.; Ataupah M.R.; Laiskodat R.D.; Bøgh C.; Soebono H.; Grijsen M.L. |
Siregar, Gladys O. (58876649500); Harianja, Maria (58876435800); Adella, Jacklyn (58994793100); Krismawati, Hana (56572770100); Sundari, Evivana S. (58876435900); Ataupah, Messe R. (58993911900); Laiskodat, Ruth D. (58994354700); Bøgh, Claus (6602120205); Soebono, Hardyanto (6508242918); Grijsen, Marlous L. (25225113700) |
58876649500; 58876435800; 58994793100; 56572770100; 58876435900; 58993911900; 58994354700; 6602120205; 6508242918; 25225113700 |
Leprosy identified in Sumba Island, eastern Indonesia: elimination targets under threat |
2024 |
The Lancet Regional Health - Southeast Asia |
26 |
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100409 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85190856063&doi=10.1016%2fj.lansea.2024.100409&partnerID=40&md5=4f24b635df4260f90f0d5f674d9efa33 |
Sumba Foundation, Sumba, Indonesia; Center of Health System and Strategy, Ministry of Health, Jakarta, Indonesia; Department of Dermatology and Venereology, Siloam Hospital, Kupang, Indonesia; Province Health Office, East Nusa Tenggara, Kupang, Indonesia; Department of Dermatology and Venereology, Gadjah Mada University, Yogyakarta, Indonesia; Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, United Kingdom |
Siregar G.O., Sumba Foundation, Sumba, Indonesia; Harianja M., Sumba Foundation, Sumba, Indonesia; Adella J., Sumba Foundation, Sumba, Indonesia; Krismawati H., Center of Health System and Strategy, Ministry of Health, Jakarta, Indonesia; Sundari E.S., Department of Dermatology and Venereology, Siloam Hospital, Kupang, Indonesia; Ataupah M.R., Province Health Office, East Nusa Tenggara, Kupang, Indonesia; Laiskodat R.D., Province Health Office, East Nusa Tenggara, Kupang, Indonesia; Bøgh C., Sumba Foundation, Sumba, Indonesia; Soebono H., Department of Dermatology and Venereology, Gadjah Mada University, Yogyakarta, Indonesia; Grijsen M.L., Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, United Kingdom |
[No abstract available] |
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awareness; disease burden; disease transmission; health care personnel; human; leprosy; multibacillary leprosy; nerve injury; Note; paucibacillary leprosy; polypharmacy; primary health care; skin care; teledermatology; telemedicine |
Wellcome Trust, WT; Sumba Foundation |
Funding text 1: The project was financially supported by the Wellcome Trust Africa Asia Programme Vietnam. The authors declare that they have no conflicts of interest. ; Funding text 2: We extend our sincere gratitude to all Sumba Foundation healthcare workers. We wish to acknowledge Ben Naafs for sharing his expertise on leprosy with the clinical team. |
Elsevier Ltd |
27723682 |
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Note |
#N/A |
#N/A |
#N/A |
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22 |
Habiburrahman M.; Sutopo S.; Sarkowi W.K. |
Habiburrahman, Muhammad (57204537114); Sutopo, Stefanus (57749107800); Sarkowi, Widya Khairunnisa (58485303400) |
57204537114; 57749107800; 58485303400 |
Plausible use of citicoline as an adjuvant in central nervous system infections: A case report and review of the literature |
2024 |
World Academy of Sciences Journal |
6 |
4 |
e39 |
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0 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85195882024&doi=10.3892%2fwasj.2024.254&partnerID=40&md5=dc2840fd07b17d5dc90d220da79c121a |
Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, 10430, Indonesia; Dr. Cipto Mangunkusumo Hospital, Central Jakarta, DKI Jakarta, 10430, Indonesia; Tebet Subdistrict Public Hospital, South Jakarta, DKI Jakarta, 12810, Indonesia; Faculty of Medicine, Imperial College London, London, SW7 2AZ, United Kingdom; School of Infection and Immunity, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, United Kingdom; Faculty of Medicine, IPB University, West Java, Bogor, 16680, Indonesia; Faculty of Medicine, Universitas Indonesia, Salemba Raya Street No. 6, Senen Subdistrict, Central Jakarta, DKI Jakarta, 10430, Indonesia |
Habiburrahman M., Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, 10430, Indonesia, Dr. Cipto Mangunkusumo Hospital, Central Jakarta, DKI Jakarta, 10430, Indonesia, Tebet Subdistrict Public Hospital, South Jakarta, DKI Jakarta, 12810, Indonesia, Faculty of Medicine, Imperial College London, London, SW7 2AZ, United Kingdom, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street No. 6, Senen Subdistrict, Central Jakarta, DKI Jakarta, 10430, Indonesia; Sutopo S., Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, 10430, Indonesia, Dr. Cipto Mangunkusumo Hospital, Central Jakarta, DKI Jakarta, 10430, Indonesia, School of Infection and Immunity, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, United Kingdom, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street No. 6, Senen Subdistrict, Central Jakarta, DKI Jakarta, 10430, Indonesia; Sarkowi W.K., Faculty of Medicine, Imperial College London, London, SW7 2AZ, United Kingdom, Faculty of Medicine, IPB University, West Java, Bogor, 16680, Indonesia |
Citicoline has been widely used for the treatment of neurological conditions of the central nervous system (CNS), and exhibit potential for infection management, providing anti-inflammatory, antiviral, antioxidant and neuroprotective properties. The present study describes the case of a 50-year-old male patient co-infected with suspected tuberculosis and COVID-19 affecting the CNS who was treated with citicoline. The study aimed to raise clinical questions and initiate a comprehensive literature review. It also aimed to explore the plausible benefits of the use of citicoline in restoring consciousness and alleviating neurological symptoms in CNS infections. In the literature review, eight studies, including two quasi-experimental studies, five literature reviews, and one case report were found to be relevant to the case of the patient described herein, and they suggested that citicoline demonstrated partial protection against cerebral malaria, prevented encephalitis sequelae when immediately administered, and inhibited coronavirus replication. Additionally, six studies reported the potential of citicoline in the treatment of neurological conditions, such as ethambutol-induced optic neuropathy, stroke, head trauma and CNS infections caused by cerebral malaria and COVID-19, compared to standard therapy. Citicoline shows promise as an adjuvant therapy for neurological complications associated with CNS infections. © 2024 Spandidos Publications. All rights reserved. |
adjuvant therapy; central nervous system infections; citicoline; evidence-based case report; neurological disorders |
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Spandidos Publications |
26322900 |
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Article |
Q3 |
317 |
14612 |
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